435 results match your criteria Arab Journal Of Gastroenterology[Journal]


The roles and interaction of FXR and PPARs in the pathogenesis of nonalcoholic fatty liver disease.

Arab J Gastroenterol 2020 May 22. Epub 2020 May 22.

Department of Gastroenterology and Hepatology, Guangzhou Digestive Diseases Center, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong Province, China. Electronic address:

Background And Study Aims: To identify the roles and interaction of farnesoid X receptor (FXR) and peroxisome proliferator activated receptors (PPARs) in Non-alcoholic fatty liver disease (NAFLD) pathogenesis.

Material And Methods: 16 C57/BL male FXR knockout (KO) mice and sex- and age-matched C57/BL wild type mice were received either standard rodent chow or high-fat and sucrose diet (Blank control, NAFLD, FXR KO and FXR KO NAFLD) for 8 weeks. After that, all mice were sacrificed. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.018DOI Listing

Liver transplantation in the era of COVID-19.

Arab J Gastroenterol 2020 May 12. Epub 2020 May 12.

Internal Medicine Department, Hepatogastroenterology Unit, Kasr Al-Ainy School Of Medicine, Cairo University, Cairo, Egypt.

Liver transplantation is considered the ultimate solution for patients with end-stage chronic liver disease or acute liver failure. Patients with liver transplant need special care starting from preoperative preparation, surgical intervention ending with postoperative care. Transplanted patients have to receive immunosuppressive therapy to prevent rejection. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214343PMC

Talin-1; other than a potential marker for hepatocellular carcinoma diagnosis.

Arab J Gastroenterol 2020 May 18. Epub 2020 May 18.

Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Ramses St, Abbassia, Cairo 11591, Egypt. Electronic address:

Background And Study Aims: Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide. Talin-1 was previously proposed as a potential novel biomarker for HCC diagnosis but with limited and inconsistent data. We aimed to study the possible role of talin-1 in diagnosis and prognostic stratification of patients with hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.017DOI Listing

Hepatocellular Carcinoma Multidisciplinary Clinic-Cairo University (HMC-CU) score: A new simple score for diagnosis of HCC.

Arab J Gastroenterol 2020 May 18. Epub 2020 May 18.

Endemic Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Study Aims: The risk of hepatocarcinogenesis depends on background liver factors, of which fibrosis is a major determinant. Serum markers and scores are of increasing importance in non-invasive diagnosis of hepatic fibrosis. Our aim was to predict the occurrence of hepatocellular carcinoma (HCC) using a non-invasive fibrosis score calculated using routine patient data. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.001DOI Listing

Predictors of recurrence and survival of hepatocellular carcinoma: A prospective study including transient elastography and cancer stem cell markers.

Arab J Gastroenterol 2020 May 18. Epub 2020 May 18.

Endemic Medicine and Hepato-gastroenterology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Study Aims: To investigate whether the measurement of liver stiffness (LSM) using fibroscan and the serum Cancer Stem Cells (CSC): Ep-CAM and cytokeratin-19, could predict the recurrence of hepatocellular carcinoma (HCC) and their impact on clinical outcome and overall survival.

Patients And Methods: This is a prospective study, including 179 HCV-related HCC patients. All patients were treated following the BCLC guidelines. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.002DOI Listing

The STAT4 and not the IFNL3 variant is associated with hepatitis B virus clearance in a population from the Khyber Pakhtunkhwa region of Pakistan.

Arab J Gastroenterol 2020 May 18. Epub 2020 May 18.

Department of Microbiology, Qauid-i-Azam University, Islamabad, Pakistan.

Background And Study Aims: Host genetic modifiers of the risk and persistence of hepatitis B virus (HBV) infection in the Pakistani population have not been clearly elucidated. Recently, two genome-wide association studies described that STAT4 and IFNL3 variants are associated with different aspects of the course of HBV infection. However, the roles of these variants in the persistence of HBV infection have not been investigated in the HBV-infected population of Pakistan. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.011DOI Listing

Elastography of pancreatic ductal adenocarcinoma following EUS-guided radiofrequency ablation (with video).

Arab J Gastroenterol 2020 May 16. Epub 2020 May 16.

Gastrointestinal Endoscopy Excellence Center and Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Pancreas Research Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Patients presenting with pancreatic ductal adenocarcinoma in an advanced inoperable stage receive chemoradiotherapy. Endoscopic ultrasound guided radiofrequency ablation (EUS-RFA) has been proposed as a new therapeutic option for these patients alongside chemotherapy. The evaluation of treatment response is mainly based on radiological evaluation of the changes in tumour size. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.014DOI Listing

Serum hepcidin levels are related to serum markers for iron metabolism and fibrosis stage in patients with chronic hepatitis B: A cross-sectional study.

Arab J Gastroenterol 2020 May 15. Epub 2020 May 15.

Gaziantep University Medical Faculty 27310 Gastroenterology, Gaziantep, Turkey.

Background And Study Aims: The clinical significance of serum parameters of iron metabolism and hepcidin in liver disease remains unknown. Therefore, this study aimed to evaluate the association of serum hepcidin levels with fibrosis stage and serum iron parameters in patients with chronic hepatitis B (CHB).

Patients And Methods: This cross-sectional study included 126 treatment-naïve patients with CHB (median age, 39. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.013DOI Listing

Primary neuroendocrine tumour of the common hepatic duct: An unexpected Klatskin-like lesion.

Arab J Gastroenterol 2020 May 15. Epub 2020 May 15.

Pathology Department, Mongi Slim Hospital, Tunis, Tunisia; Medicine Faculty of Tunis, Tunis El Manar University, Tunis, Tunisia.

The biliary system is an uncommon location for neuroendocrine tumours (NETs), and within this system, the common hepatic duct is an even more rare site for NETs. Clinical and radiological presentations are challenging because these tumours may be preoperatively confused with Klatskin-like lesions. Here we report a well-differentiated grade 2 NET arising from the common hepatic duct in a 64-year-old female. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.003DOI Listing

Giant stentolith: A rare complication of long-dwelling biliary endoprosthesis.

Arab J Gastroenterol 2020 May 15. Epub 2020 May 15.

Department of Surgical Gastroenterology, King George's Medical University, Lucknow, UP, India.

Endoscopic biliary stenting is performed for various indications in routine clinical practice. Plastic stents are indicated primarily for short-term biliary decompression and require removal or exchange after 12-16 weeks. However, patients who become asymptomatic after the procedure may not return for scheduled stent removal and subsequently present with severe complications. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.008DOI Listing

Prognostic significance of peritumoural and intratumoural budding in intestinal-type gastric adenocarcinoma.

Arab J Gastroenterol 2020 May 15. Epub 2020 May 15.

Department of Public Health, Shaanxi University of Chinese Medicine, China.

Background And Study Aims: Tumour budding (TB) at the invasive front, termed peritumoural budding (PTB), is an established prognostic factor for many solid tumours. However, intratumoural budding (ITB) in gastric adenocarcinoma (GAC), which is frequently observed at the tumour centre, particularly in tumour biopsy tissues, remains poorly understood. Hence, we aimed to determine the correlation of ITB with PTB and their connection with clinicopathological characteristics as well as their prognostic value in GAC. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.005DOI Listing

First case of paralytic ileus after endoscopic mucosal resection of caecal polyp.

Arab J Gastroenterol 2020 May 15. Epub 2020 May 15.

University of Toledo Medical Center, Department of Internal Medicine, 3000 Arlington Avenue, MS 1150, Toledo, OH 43614, United States; Division of Gastroenterology, University of Toledo, 3000 Arlington Avenue, MS 1150, Toledo, OH 43614, United States.

Endoscopic mucosal resection (EMR) is a technique developed for the removal of sessile or flat neoplastic lesions confined to the superficial layers (mucosa and submucosa) of the gastrointestinal tract. Bleeding and perforation are well-known complications of EMR. Here we report the first case of paralytic ileus after EMR of a caecal polyp. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.009DOI Listing

Effect of Ramadan fasting on Muslim recipients after living donor liver transplantation: A single center study.

Arab J Gastroenterol 2020 May 15. Epub 2020 May 15.

Department of Tropical Medicine, Ain Shams Center for Organ Transplantation (ASCOT), Ain Shams University, Cairo, Egypt.

Background And Study Aims: Several factors affect the quality of life and personal well-being of transplant recipients, including Ramadan fasting for Muslims. This study aimed to assess the effect of Ramadan fasting on the renal and liver functions of liver transplantation recipients and to propose a protocol for adapting an Immunosuppression regimen and follow-up schedule for patients wishing to fast after liver transplantation.

Patients And Methods: This prospective study was conducted on 45 recipients who wished to fast Ramadan from 17th May to 14th June 2018, at Ain Shams Center for Organ Transplantation, Cairo, Egypt. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.05.001DOI Listing

Characteristics and outcome of patients presenting with acute Pancreatitis: A one-year descriptive study from a tertiary care center in Lebanon.

Arab J Gastroenterol 2020 May 11. Epub 2020 May 11.

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Division of Gastroenterology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Aim: To determine the aetiology, hospital course, and outcome of patients diagnosed with acute pancreatitis (AP) presenting to the Emergency Department (ED) of a tertiary care center in Lebanon.

Patients And Methods: Using a retrospective cross-sectional study design, records of all patients presenting to the ED with elevated lipase over one calendar year (2016) were reviewed. Patients diagnosed with AP according to the revised Atlanta classification were identified. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.015DOI Listing

Gluten-free diet yesterday, today and tomorrow: Forecasting using Google Trends data.

Arab J Gastroenterol 2020 Apr 21. Epub 2020 Apr 21.

Department of Human Nutrition and Metabolomics, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland.

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http://dx.doi.org/10.1016/j.ajg.2020.04.004DOI Listing

COVID-19: Mitigation or suppression?

Arab J Gastroenterol 2020 03;21(1):1-2

Endemic Medicine Department, Faculty of Medicine, Cairo University, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.ajg.2020.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172840PMC

Brunner's gland adenoma is a rare cause of upper gastrointestinal bleeding: A case report and literature review.

Arab J Gastroenterol 2020 Apr 20. Epub 2020 Apr 20.

Gastrointestinal Endoscopy and Liver Unit, Kasr Al-Ainy, Faculty of Medicine, Cairo University, Cairo, Egypt.

Brunner's gland adenoma is a rare benign tumour that arises from Brunner's glands in the duodenum. Lesions are usually incidentally discovered during oesophagogastroduodenoscopy. However, in some cases, they may present clinically with vague abdominal symptoms or bleeding. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.04.006DOI Listing

Hepatic and gastrointestinal involvement in coronavirus disease 2019 (COVID-19): What do we know till now?

Authors:
Sherief Musa

Arab J Gastroenterol 2020 Mar 3;21(1):3-8. Epub 2020 Apr 3.

Endemic Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:

Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19), has posed a serious threat to global health and is currently causing a major pandemic. While patients typically present with fever and a respiratory illness, mounting evidence indicates that patients might also report extra-pulmonary manifestations, including those affecting the liver and gastrointestinal tract. This involvement may have important implications to the disease management, transmission, and prognosis, especially in patients with pre-existing hepatic or digestive co-morbidities. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174834PMC

Changes of Wnt/β-catenin signalling, BMP2, and BMP4 in the jejunum during ageing in rats.

Arab J Gastroenterol 2020 Mar 30;21(1):43-48. Epub 2020 Mar 30.

Medical College of China Three Gorges University, Yichang 443002, China. Electronic address:

Background And Study Aims: The renewal of intestinal epithelium is maintained by intestinal stem cells (ISCs). Studies have found an age-dependent increase of Esg/Dl progenitor cells in the midgut of Drosophila. However, changes of ISCs and the molecular regulation in mammalian animals with age are yet unknown. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.12.004DOI Listing

Effect of enteral erythropoietin on feeding-related complications in preterm newborns: A pilot randomized controlled study.

Arab J Gastroenterol 2020 Mar 30;21(1):37-42. Epub 2020 Mar 30.

Department of Paediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background And Study Aims: To evaluate the effects of enteral administration of recombinant human erythropoietin (rhEPO) on feeding-related complications in preterm infants.

Patients And Methods: This double-blind, randomized controlled pilot study enrolled 120 preterm infants born ≤ 32 weeks' gestation who were admitted to the neonatal intensive care unit in a tertiary hospital; 60 patients randomly received recombinant human erythropoietin while the other 60 received placebo. Newborns who underwent cardiopulmonary resuscitation, infants with genetic syndromes, infants with inborn errors of metabolism, infants with major congenital or acquired gastrointestinal tract malformations, infants with previous use of parenteral growth factors such as recombinant human erythropoietin and granulocyte-macrophage colony-stimuating factor (GM-CSF) and infants previously treated with intravenous immunoglobulin were excluded. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.01.001DOI Listing

The association between smoking and both types of microscopic colitis: A systematic review and meta-analysis.

Arab J Gastroenterol 2020 Mar 30;21(1):9-18. Epub 2020 Mar 30.

Department of Gastroenterology, East Tennessee State University, Johnson City, TN, USA.

Background And Study Aims: It has been suggested that smoking may be associated with microscopic colitis (MC) in some studies; however, there are conflicting results in the current literature with many of these studies having significant limitations. Our study aims to offer a meta-analysis evaluating the association between MC, including both its subtypes, and smoking.

Patients And Methods: A systemic review was conducted in PUBMED, Embase, PubMed Central, and ScienceDirect databases from inception through December 2019. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.01.004DOI Listing

EUS-guided transhepatic antegrade stenting of dilated intrahepatic duct due to a pancreatic head malignancy (with videos).

Arab J Gastroenterol 2020 03 30;21(1):65-66. Epub 2020 Mar 30.

Gastrointestinal Endoscopy Excellence Center and Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; Pancreas Research Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.ajg.2019.12.002DOI Listing

The utility of digital cholangioscopy (SpyGlass DS) in biliary and pancreatic diseases: A clinical feasibility study at two tertiary care centers in Saudi Arabia (with Videos).

Arab J Gastroenterol 2020 Mar 13;21(1):49-53. Epub 2020 Mar 13.

King Fahad Medical City, Department of Gastroenterology and Hepatology, Riyadh, Saudi Arabia. Electronic address:

Background And Study Aim: Since its inception in 2007, single-operator cholangioscopy (SOC) has gained popularity for many diagnostically and therapeutically challenging biliary and pancreatic conditions. Many studies have been published to evaluate the feasibility, usefulness, cost-effectiveness, and safety profile of the first generation. This paper is a descriptive study in which we aim to share the experience of two tertiary care centers with the novel version of SOC, SpyGlass DS. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.12.003DOI Listing

Emotional dysregulation in adolescents with functional gastrointestinal disorders.

Arab J Gastroenterol 2020 Mar 13;21(1):24-27. Epub 2020 Mar 13.

Department of Pediatrics, Kırıkkale University Faculty of Medicine, Turkey.

Background And Study Aims: In various gastrointestinal system diseases, emotional dysregulation has been shown to reduce pain tolerance and increase the severity of the disease. Increased emotional dysregulation during the adolescence period causes gastrointestinal symptoms to be more frequent and severe. In this study, Child Depression Inventory (CDI) scores were investigated in patients admitted to our clinic with functional gastrointestinal disorders. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.02.002DOI Listing

Association of duodenal eosinophilia with Helicobacter pylori-negative functional dyspepsia.

Arab J Gastroenterol 2020 Mar 13;21(1):19-23. Epub 2020 Mar 13.

Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Background And Study Aims: The pathogenesis of functional dyspepsia (FD) is complex and still remains to be established. Recent studies support duodenal inflammation with increased infiltration of eosinophils and a higher level of systemic cytokines among patients with FD. These findings may help to understand the underlying pathophysiology of FD. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.03.001DOI Listing

Gastric sarcoidosis: Rare revealing feature of systemic sarcoidosis.

Arab J Gastroenterol 2020 Mar 27;21(1):62-64. Epub 2020 Feb 27.

Internal Medicine Department, Military Hospital of Tunis, 1008 Montfleury, Tunisia; Auto Immunity Research Unit UR17DN02, Tunisia; University of Tunis El Manar, Faculty of Medicine of Tunis, Tunisia.

Gastric sarcoidosis is clinically manifest in less than 1% of patients with systemic disease. Stomach is the most commonly involved site. Clinical signs are non-specific. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.02.001DOI Listing

Plummer-Vinson Syndrome in a Crohn's disease patient.

Arab J Gastroenterol 2020 Mar 19;21(1):59-61. Epub 2020 Feb 19.

Department of Gastroenterology, 401 General Military Hospital of Athens, Athens 11525, Greece. Electronic address:

Plummer Vinson Syndrome (PVS), a rare condition complicating iron deficiency anaemia, manifests as a classic triad of dysphagia, anaemia and oesophageal web. Iron deficiency is the commonest systematic complication of Crohn's disease with only one described case of a Crohn's disease patient combined with PVS in the literature. We present a case of PVS complicating Crohn's disease in a 38-years-old female patient under treatment with the biologic agent Ustekinumab (human interleukin 12/23 monoclonal antibody) suffering from a progressively worsening dysphagia. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.01.006DOI Listing

Autonomic and diastolic dysfunction association with quality of life impairment in cirrhotic patients.

Arab J Gastroenterol 2020 Mar 19;21(1):32-36. Epub 2020 Feb 19.

Department of Haematology, Trakya University, Medical Faculty, Edirne, Turkey.

Background And Study Aims: Cirrhosis is a multisystem disorder characterized by hyperdynamic circulation which can progress to multiple organ dysfunctions. Recent studies have demonstrated autonomic dysfunction and cirrhotic cardiomyopathy including diastolic dysfunction, systolic dysfunction with electrophysiologic abnormalities in patients with cirrhosis. Due to the long and complicated course of the disease, health related quality of life is affected. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.01.003DOI Listing

Multiple myeloma with primary amyloidosis presenting with digestive symptoms: A case report and literature review.

Arab J Gastroenterol 2020 Mar 20;21(1):54-58. Epub 2020 Feb 20.

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Yong'an Road, No. 95, Beijing 100050, China. Electronic address:

We present a case of multiple myeloma with primary systemic amyloidosis presenting with digestive symptoms in a 32-year-old male. Initial symptoms included upper abdominal discomfort for 4 months, and stool with mucous and blood for 1 month. Erosive gastritis, Helicobacter pylori infection, haematochezia, and weight loss were noted, but without bone pain, anaemia, or hypercalcaemia. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.01.002DOI Listing

Diagnostic values of duodenal endoscopic markers in paediatric coeliac patients.

Arab J Gastroenterol 2020 Mar 19;21(1):28-31. Epub 2020 Feb 19.

Tishreen University, Latakia, Syria.

Background And Study Aims: The recognition of suggestive endoscopic markers in the duodenum during open access endoscopy can help identifying patients who are likely to develop coeliac disease (CD). This study aims to determine the diagnostic accuracy of duodenal endoscopic markers for the diagnosis of CD.

Patients And Methods: All children (0-15 years) who underwent oesophagogastroduodenoscopy (EGD) for any reason suggestive of CD at the paediatric department of Al-Assad University Hospital in Latakia, Syria during a 4-year period (from January 2010 to December 2013) were retrospectively included, in the study; this yielded a consecutive cohort without selection bias. Read More

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http://dx.doi.org/10.1016/j.ajg.2020.01.005DOI Listing

A tribute to Meinhard Classen.

Arab J Gastroenterol 2019 12;20(4):181-182

GI-Endoscopy and Tropical Medicine Department, Faculty of Medicine Cairo University, Egypt. Electronic address:

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http://dx.doi.org/10.1016/j.ajg.2019.11.006DOI Listing
December 2019

Endoscopic full-thickness resection for a duodenal gastrointestinal stromal tumour.

Arab J Gastroenterol 2019 Dec 6;20(4):211-212. Epub 2019 Dec 6.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajg.2019.12.001DOI Listing
December 2019

Drug-induced pancreatitis: An update.

Arab J Gastroenterol 2019 Dec 2;20(4):183-188. Epub 2019 Dec 2.

Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China. Electronic address:

Drug-induced pancreatitis is a disease that is receiving increasing attention. This article reviews the advances in the incidence, risk factors, pathogenesis, diagnosis, treatment and prevention of drug-induced pancreatitis by reviewing the literature on drug-induced pancreatitis, especially in the literature of the latest 10 years. The incidence of drug-induced pancreatitis is relatively low, however, there is an increasing trend with the widespread use of drugs, and the incidence seems to be related to regional distribution. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.11.005DOI Listing
December 2019

Treatments of nonalcoholic fatty liver disease in adults who have no other illness: A Review article.

Arab J Gastroenterol 2019 Dec 2;20(4):189-197. Epub 2019 Dec 2.

Department of Clinical Pharmacy, Nephrology and Kidney Transplant Research Center, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. In the absence of treatment, NAFLD can damage the liver tissue and even have extra-hepatic complications. No therapeutic regimen has ever been approved for the treatment of this disease. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.11.004DOI Listing
December 2019

Circulating microRNAs (miR-21, miR-223, miR-885-5p) along the clinical spectrum of HCV-related chronic liver disease in Egyptian patients.

Arab J Gastroenterol 2019 Dec 2;20(4):198-204. Epub 2019 Dec 2.

Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:

Background And Study Aims: MicroRNAs (miRNAs), small single stranded RNAs, function in the post-transcriptional regulation of gene expression and incorporated in pathogenesis of HCV related chronic liver disease. This study was designed to evaluate the significance of serum miR-21, miR-223, and miR-885-5p as biomarkers in various clinicopathological stages of HCV related chronic liver disease.

Patients And Methods: Serum miR-21, miR-223, and miR-885-5p were quantified by quantitative RT PCR in 60 patients with HCV-related liver disease (presumably genotype 4), in addition to 25 healthy controls. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.11.003DOI Listing
December 2019

Endoscopic ultrasound-guided fine-needle aspiration of sigmoid colon cancer undiagnosed with endoscopic biopsy.

Arab J Gastroenterol 2019 Dec 20;20(4):209-210. Epub 2019 Nov 20.

Department of Gastroenterology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.

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http://dx.doi.org/10.1016/j.ajg.2019.11.001DOI Listing
December 2019

WITHDRAWN: Giant gastric lipoma presenting as partial gastric outlet obstruction.

Arab J Gastroenterol 2019 Nov 21. Epub 2019 Nov 21.

Department of Gastroenterology and Hepatology, The Brooklyn Hospital Center - Clinical Affiliate of The Mount Sinai Hospital, Brooklyn, NY 11201, USA.

This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www. Read More

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http://dx.doi.org/10.1016/j.ajg.2018.12.004DOI Listing
November 2019

Effect of low dose albumin administration in spontaneous bacterial peritonitis on renal function and survival.

Arab J Gastroenterol 2019 Dec 20;20(4):205-208. Epub 2019 Nov 20.

Department of Gastroenterology, Habib Thameur Hospital, 3, rue Ali Ben Ayed, Montfleury 1002, Tunis, Tunisia.

Background And Study Aims: Current guidelines favour albumin administration during spontaneous bacterial peritonitis (SBP). However, its use is limited in clinical practice and low doses are preferred. The aim of our study was to determine the effect of low dose albumin perfusion during SBP on mortality and prevention of hepatorenal syndrome (HRS) in cirrhotic patients. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.11.002DOI Listing
December 2019

Paediatric hepatitis C virus infection and its treatment: Present, past, and future.

Arab J Gastroenterol 2019 Sep 1;20(3):163-174. Epub 2019 Oct 1.

Misr International University, Cairo, Egypt. Electronic address:

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the world. It is a challenging medico-social problem in the paediatric population. High HCV infection rates are reported in low and middle incomes countries. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.09.003DOI Listing
September 2019
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Does rectal ketoprofen prevent post ERCP pancreatitis?

Arab J Gastroenterol 2019 Sep 30;20(3):141-144. Epub 2019 Sep 30.

Department of Gastroenterology, University Hospital of Notre Dame De Secours Byblos, Faculty of Medicine and Sciences, Holy Spirit University of Kaslik, Lebanon.

Background And Study Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is a commonly used procedure in the management of pancreatic and biliary diseases. Acute pancreatitis is the most common complication following ERCP. Among many medications, nonsteroidal anti-inflammatory drugs (NSAIDs) were subject of numerous trials concerning post ERCP pancreatitis (PEP) prophylaxis. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.09.004DOI Listing
September 2019
1 Read

Highlights from Gastro Update Europe - Budapest June 26-27, 2019.

Authors:
Guido N J Tytgat

Arab J Gastroenterol 2019 Sep 27;20(3):148-162. Epub 2019 Sep 27.

Department Gastroenterology-Hepatology, Meibergdreef, 1105 AZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/j.ajg.2019.09.002DOI Listing
September 2019

Egyptian recommendations for management of Helicobacter pylori infection: 2018 report.

Arab J Gastroenterol 2019 Sep 26;20(3):175-179. Epub 2019 Sep 26.

Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1016/j.ajg.2019.09.001DOI Listing
September 2019
2 Reads

The value of mRNA expression of S100A8 and S100A9 as blood-based biomarkers of inflammatory bowel disease.

Arab J Gastroenterol 2019 Sep 25;20(3):135-140. Epub 2019 Sep 25.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Study Aims: Non-invasive biomarkers of inflammatory bowel diseases (IBD) are of critical importance. Here, we evaluated the S100A8 and S100A9 mRNA expression, as the heterodimers of calprotectin, in the blood leucocytes of IBD patients to find how their expression associates with the disease characteristics.

Patients And Methods: In this cross-sectional study, 59 IBD patients and 30 healthy subjects were included. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.07.002DOI Listing
September 2019
2 Reads

Dysphagia aortica in a young patient with Behcet's Disease: Case report.

Arab J Gastroenterol 2019 Sep 24;20(3):145-147. Epub 2019 Sep 24.

Department of Surgery, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland. Electronic address:

Dysphagia aortica is a rare aetiology of dysphagia resulting from an abnormality in thoracic aorta that causes extrinsic compression on the oesophagus. Dysphagia aortica includes aortic aneurysm, aortic dissection or even tortuous aorta and is seldom considered in the differential diagnosis of dysphagia. Herein, we report a 30-year-old man with Behcet's disease who presented with rapid progressive dysphagia and diagnosed as dysphagia aortica caused by saccular aortic aneurysm complicated by large para-aortic haematoma compressing the oesophagus. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.07.001DOI Listing
September 2019
2 Reads

Up-regulation of TIMP-3 and RECK decrease the invasion and metastasis ability of colon cancer.

Arab J Gastroenterol 2019 Sep 23;20(3):127-134. Epub 2019 Sep 23.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, PR China. Electronic address:

Background And Study Aims: Although the function of microRNA21 (miR-21) in the invasion and metastasis of colon cancer has been extensively studied, the mechanisms of invasion and migration related pathways between and its targets are still not elucidated. This study explored the mechanisms of the pathway between miR-21 and the target genes in vitro and in vivo.

Materials And Methods: We transfected pmiRZip21 or Leti3 into colon cancer cells. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.07.003DOI Listing
September 2019
1 Read

Vitamin D, linoleic acid, arachidonic acid and COX-2 in colorectal cancer patients in relation to disease stage, tumour localisation and disease progression.

Arab J Gastroenterol 2019 Sep 1;20(3):121-126. Epub 2019 Jul 1.

Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Wielicka St. 265, Krakow 30-663, Poland.

Background And Study Aims: Evidence shows that vitamin D and cyclooxygenase type 2 (COX-2) might play role in aetiology/progression of cancer. It is suggested that antitumour effect of vitamin D depends on vitamin D-receptor (VDR) expression. Aim of the study was to determine vitamin D and polyunsaturated fatty acids in colorectal cancer patients. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.05.007DOI Listing
September 2019

Serological screening for coeliac disease in patients with juvenile idiopathic arthritis.

Arab J Gastroenterol 2019 Jun 7;20(2):95-98. Epub 2019 Jun 7.

Paediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Turkey.

Background And Study Aims: Juvenile idiopathic arthritis (JIA) is characterized by autoimmune aetiology. A gene locus 4q27 related to rheumatoid arthritis, psoriatic arthritis, and coeliac disease is associated with susceptibility to JIA. There are reports indicating several patients with JIA had been diagnosed with CD. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.05.005DOI Listing
June 2019
19 Reads

Six-minute walk test before and after large-volume paracentesis in cirrhotic patients with refractory ascites: A pilot study.

Arab J Gastroenterol 2019 Jun 7;20(2):81-85. Epub 2019 Jun 7.

Department of Chest Diseases and Tuberculosis, Faculty of Medicine, Assiut University Hospital, Assiut University, Assiut 71515, Egypt.

Background/aims: Functional impairment is common among cirrhotic patients with refractory ascites, and improvement in functional impairment is an expected issue after paracentesis. The six-minute walk test (6MWT) is considered an objective test for functional activity. No published data have evaluated the 6MWT among cirrhotic patients with refractory ascites before and after large-volume paracentesis. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.05.009DOI Listing
June 2019
5 Reads

Endoscopic ultrasound-guided fine needle aspiration in diagnosis of cystic pancreatic lesions.

Arab J Gastroenterol 2019 Jun 7;20(2):86-90. Epub 2019 Jun 7.

Internal Medicine, Faculty of Medicine, Cairo University, Egypt.

Background And Study Aims: pancreatic cysts are commonly found lesions and proper diagnosis is very important for planning further management. The study aims to evaluate the role of cyst fluid amylase and tumour markers as cancer antigen (CA 19-9) and carcinoembryonic antigen (CEA) in addition to mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign lesions.

Patients And Methods: This prospective study was conducted on 184 patients diagnosed to have pancreatic cystic lesions from January 2013 to January 2018. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.05.008DOI Listing
June 2019
8 Reads

Egyptian liver library: An indexed database for liver disease evidence in Egypt.

Arab J Gastroenterol 2019 Jun 4;20(2):109-113. Epub 2019 Jun 4.

Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.

Liver diseases are among the most challenging health care problems worldwide. In Egypt, we established different care programs to combat liver diseases including schistosomiasis and viral hepatitides. A lot of research work addressing liver diseases in Egypt have been published with special focus on these two major fields. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16871979193004
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http://dx.doi.org/10.1016/j.ajg.2019.05.004DOI Listing
June 2019
37 Reads