37,094 results match your criteria Arab Gulf Journal Of Scientific Research[Journal]

An overview on the exploring the interaction of inorganic nanoparticles with microtubules for the advancement of cancer therapeutics.

Int J Biol Macromol 2022 May 23. Epub 2022 May 23.

Laboratory Experimental Oncology, Department of Pathology, Erasmus MC, 3015GD Rotterdam, the Netherlands. Electronic address:

Targeting microtubules (MTs), dynamic and stable proteins in cells, by different ligands have been reported to be a potential strategy to combat cancer cells. Inorganic nanoparticles (NPs) have been widely used as anticancer, antibacterial, and free radical scavenging agents, where the come in contact with biological macromolecules. The interaction between the NPs and biological macromolecules like MTs frequently occurs through different mechanisms. Read More

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Non-alcoholic Fatty Liver Disease: Current Global Burden.

Semin Liver Dis 2022 May 26. Epub 2022 May 26.

Internal Medicine Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt.

The map and global disease burden of chronic liver diseases are markedly changing, with non-alcoholic fatty liver disease (NAFLD) becoming the most common cause of liver affection coinciding with the current epidemics of obesity, type 2 diabetes, and metabolic syndrome. Understanding the incidence and prevalence of NAFLD is critical because of its linkage to a significant economic burden of hospitalization and changing patterns in consequences such as liver transplantation. Moreover, the long-term average healthcare expenses of NAFLD patients have exceeded those of other liver diseases. Read More

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A cationic amino acid polymer nanocarrier synthesized in supercritical CO for co-delivery of drug and gene to cervical cancer cells.

Colloids Surf B Biointerfaces 2022 May 18;216:112584. Epub 2022 May 18.

Department of Nanoscience and Technology, Bharathiar University, Coimbatore, Tamilnadu 641046, India. Electronic address:

The present study was undertaken to investigate the ability of a drug curcumin-loaded polymer to inhibit the growth of cervical cancer cells by enhancing the anti-cancer efficiency of curcumin. We synthesized poly(methacryloyl beta-alanine) (PMBA) as a nanocarrier by radical polymerization in supercritical CO. The results showed that the curcumin encapsulated and folic acid (FA)-treated PMBA ([email protected]) for 24 h activated the reactive oxygen species-mediated programmed cell death machinery in HeLa cells. Read More

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Snuff box radial artery aneurysm: A case report and literature review.

Int J Surg Case Rep 2022 May 18;95:107213. Epub 2022 May 18.

Department of Vascular Surgery, Tawam Hospital, United Arab Emirates.

Introduction And Importance: Distal radial artery aneurysms in the anatomical snuff box are rare.

Case Presentation: Herein, we present the case of a snuff box radial artery aneurysm in a female patient with a possible history of trauma and discuss the evaluation and management of snuff box radial artery aneurysms. The aneurysm in this case was resected without reconstruction because of a normal preoperative Allen test finding and intraoperative evidence of adequate hand perfusion after the aneurysm was excised. Read More

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Hepatitis A in the Eastern Mediterranean Region: a comprehensive review.

Hum Vaccin Immunother 2022 May 26:2073146. Epub 2022 May 26.

GSK, Wavre, Belgium.

Introduction: With 583 million inhabitants, the Eastern Mediterranean Region (EMR) is a worldwide hub for travel, migration, and food trade. However, there is a scarcity of data on the epidemiology of the hepatitis A virus (HAV).

Methods: The MEDLINE and grey literature were systematically searched for HAV epidemiological data relevant to the EMR region published between 1980 and 2020 in English, French, or Arabic. Read More

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Assessment of Alternative Medicine Use, Costs, and Predictors of Medication Adherence among Diabetes Mellitus Patients in Palestine.

Endocr Metab Immune Disord Drug Targets 2022 May 23. Epub 2022 May 23.

College of Pharmacy, AlZaytoonah University of Jordan, Amman, Jordan.

Background: Diabetes Mellitus (DM) is considered the fourth leading cause of death in Palestine, with a prevalence of 9.1% in patients aged 20-79 years, and is predicted to increase to 20.6% by 2020. Read More

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Deciphering a hexameric protein complex with Angstrom optical resolution.

Elife 2022 May 26;11. Epub 2022 May 26.

Max Planck Institute for the Science of Light, Erlangen, Germany.

Cryogenic optical localization in three dimensions (COLD) was recently shown to resolve up to four binding sites on a single protein. However, because COLD relies on intensity fluctuations that result from the blinking behavior of fluorophores, it is limited to cases where individual emitters show different brightness. This significantly lowers the measurement yield. Read More

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Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management.

Drug Deliv 2022 Dec;29(1):1663-1674

Pharmaceutics Department, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.

Despite the fact of availability of several treatments for breast cancer, most of them fail to attain the desired therapeutic response due to their poor bioavailability, high doses, non-selectivity and as a result systemic toxicity. Here in an attempt made to study the transdermal effect of leflunomide (LEF) against breast cancer. In order to improve the poor physicochemical properties of LEF, it was loaded into cubosomes. Read More

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December 2022

Reliability and validity of the Arabic version of the Consultation and Relational Empathy (CARE) measure.

Fam Pract 2022 May 25. Epub 2022 May 25.

Lebanese American University, School of Arts and Sciences, Department of Social and Education Sciences, PO Box 13-5053, Beirut, Lebanon.

Purpose: Empathy is the ability to communicate an understanding of an individual's subjective experience. It plays a vital role in the physician-patient relationship and improves clinical outcomes. This increases the importance of measuring and studying empathy in the clinical setting. Read More

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Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental disorder.

Clin Genet 2022 May 26. Epub 2022 May 26.

Institute of Human Genetics, University of Münster, Münster, Germany.

Biallelic variants of the gene encoding for the zinc-finger protein 142 (ZNF142) have recently been associated with intellectual disability (ID), speech impairment, seizures, and movement disorders in nine individuals from five families. In this study, we obtained phenotype and genotype information of 26 further individuals from 16 families. Among the 27 different ZNF142 variants identified in the total of 35 individuals only four were missense. Read More

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Heat Stress-Mediated Constraints in Maize () Production: Challenges and Solutions.

Front Plant Sci 2022 29;13:879366. Epub 2022 Apr 29.

School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China.

An increase in temperature and extreme heat stress is responsible for the global reduction in maize yield. Heat stress affects the integrity of the plasma membrane functioning of mitochondria and chloroplast, which further results in the over-accumulation of reactive oxygen species. The activation of a signal cascade subsequently induces the transcription of heat shock proteins. Read More

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Zinc Nutrition Responses to Agronomic and Yield Traits, Kernel Quality, and Pollen Viability in Rice ( L.).

Front Plant Sci 2022 9;13:791066. Epub 2022 May 9.

Agricultural Botany Department, Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria, Egypt.

Rice ( L.) is one of the major cereal crops worldwide with wheat and maize. A total of two field experiments were performed to evaluate the response of some rice cultivars to various foliar zinc (Zn) concentrations based on different measurements, such as agronomic, yield, yield compounds, and grain technological parameters. Read More

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Consumption of Food Components of the Mediterranean Diet Decreases the Risk of Breast Cancer in the Makkah Region, Saudi Arabia: A Case-Control Study.

Front Nutr 2022 18;9:863029. Epub 2022 Apr 18.

Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il, Ha'il, Saudi Arabia.

Background: Breast cancer is one of the leading causes of death worldwide, it affects both men and women. In Saudi Arabia, breast cancer has been the most prevalent type of cancer in women, for the past few years. Dietary habits and cultural beliefs vary according to region, and further studies are required to demonstrate the relationship between these dietary habits and cultural beliefs and the risk of developing breast cancer. Read More

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A prevalence and molecular characterization of novel pathogenic strains of Macrococcus caseolyticus isolated from external wounds of donkeys in Khartoum State -Sudan.

BMC Vet Res 2022 May 25;18(1):197. Epub 2022 May 25.

Department of Microbiology, Faculty of Veterinary Medicine, University of Khartoum, Khartoum, Sudan.

A pathogenic strain of Macrococcus caseolyticus (M. caseolyticus) was isolated from wounds infection during an investigation on donkeys in Khartoum State. (122) samples were collected from external wounds (head, abdomen, back and leg) during different seasons. Read More

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Understanding the relationship between illness perceptions of breast cancer and perceived risk in a sample of U.A.E. female university students: the role of comparative risk.

BMC Womens Health 2022 May 25;22(1):193. Epub 2022 May 25.

William James Center for Research, ISPA - Instituto Universitário, Lisbon, Portugal.

Background: In the Middle East region, the incidence of breast cancer (BC) has substantially increased in the last years. Despite a considerable body of research about BC in Arab countries, how illness perceptions of healthy women about BC may influence risk perception is unknown.

Methods: A cross-sectional survey was conducted on a sample of 298 young Emirati women. Read More

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Cancer incidence and mortality and risk factors in member countries of the " Belt and Road " initiative.

BMC Cancer 2022 May 25;22(1):582. Epub 2022 May 25.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China (Mailing address: 27 Nanwei Road, Xicheng District, Beijing, 100050, China.

Background: At present, "Belt and Road" ("B&R") member states (accounting for about 61.78% of the world's population) face different types of cancer threats to varying degrees. We analyzed the incidence and mortality and risk factors of cancer in the member countries of the "B&R" to explore the basis of health and medical cooperation between countries and provide a foundation for formulating cancer prevention and control policies for building a healthy "B&R. Read More

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Midfrontal theta power encodes the value of haptic delay.

Sci Rep 2022 May 25;12(1):8869. Epub 2022 May 25.

Engineering Division, New York University Abu Dhabi, Saadiyat Island, Abu Dhabi, 129188, United Arab Emirates.

The use of haptic technologies in modern life scenarios is becoming the new normal particularly in rehabilitation, medical training, and entertainment applications. An evident challenge in haptic telepresence systems is the delay in haptic information. How humans perceive delayed visual and audio information has been extensively studied, however, the same for haptically delayed environments remains largely unknown. Read More

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Clinical properties of the 6-clicks and Functional Status Score for the ICU in a hospital in the United Arab Emirates.

Arch Phys Med Rehabil 2022 May 22. Epub 2022 May 22.

Cleveland Clinic Abu Dhabi, Department of Inpatient Therapies and Rehabilitation, Abu Dhabi, United Arab Emirates.

Objective: To determine measurement properties of the Activity Measure for Post-Acute Care Inpatient Mobility Short Form (6-clicks) and Functional Status Score for the Intensive Care Unit (FSS-ICU).

Design: Retrospective analysis of scores from a cohort of patients over twenty-four months. Outcome measures were administered to patients referred to physical therapy on admission and discharge. Read More

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Mechanism of chromium-induced toxicity in lungs, liver, and kidney and their ameliorative agents.

Biomed Pharmacother 2022 May 24;151:113119. Epub 2022 May 24.

Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India. Electronic address:

Heavy metal Chromium (Cr), can adversely affect humans and their health if accumulated in organs of the body, such as the lungs, liver, and kidneys. Cr (VI) is highly toxic and has a higher solubility in water than Cr (III). One of the most common routes for Cr exposure is through inhalation and is associated with liver, lung, kidney damage, widespread dermatitis, GI tract damage, human lung cancer, cardiomyopathies, and cardiovascular disease. Read More

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Observations on the glycosylation of the term placenta of the Indo-Pacific Bottlenose Dolphin (Tursiops aduncus): A lectin histochemical study.

Placenta 2022 May 19;124:37-43. Epub 2022 May 19.

Sharjah Equine Hospital, Bridge No 6, Al Daid Road, Al Atain Area, Sharjah, United Arab Emirates. Electronic address:

Introduction: Little is known about the glycosylation of placental villi and areolae of cetaceans. Term tissue from the delivered placenta of an Indo-Pacific Bottlenose Dolphin (Tursiops aduncus) was examined using lectin histochemistry to compare trophoblast glycosylation in these two locations.

Methods: Placental blocks fixed in 10% formalin were resin-embedded before semithin sections were stained with 24 biotinylated lectins and an avidin-biotin revealing system. Read More

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Older Adults' Satisfaction with Telemedicine During the COVID-19 Pandemic: A Systematic Review.

Telemed J E Health 2022 May 25. Epub 2022 May 25.

Mohammed Bin Rashid School of Government, Dubai, United Arab Emirates.

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A Hypothesis-Generating Clinical Study We Should Be Concerned About.

Rashid Nadeem

Crit Care Med 2022 Jun 19;50(6):e606-e607. Epub 2022 May 19.

Intensive Care Medicine, Dubai Hospital, Dubai, United Arab Emirates.

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Evaluation of Drug Use Pattern in Pediatric Outpatient Clinics in a Tertiary Teaching Hospital Using WHO Drug-Prescribing Indicators.

J Multidiscip Healthc 2022 18;15:1143-1151. Epub 2022 May 18.

Department Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.

Purpose: The main aim of the study is to assess physicians' prescribing patterns using the World Health Organization (WHO) prescribing indicators among pediatric outpatient clinics, and to identify areas in need of intervention regarding the rational use of medicines among pediatric outpatients in Jordan.

Methods: This is a descriptive observational cross-sectional study that was conducted at the outpatient pediatric clinics at Jordan University Hospital (JUH). During the study period, prescriptions were collected over a period of two months. Read More

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Traumatic brain injuries and maxillofacial fractures: a systematic review and meta-analysis.

Oral Maxillofac Surg 2022 May 24. Epub 2022 May 24.

Ajman University, Ajman, United Arab Emirates.

Traumatic brain injuries (TBIs) associated with maxillofacial fractures (MFFs) are a public health concern worldwide, especially among adult-aged males. There is an urgent need for early detection of associated TBIs in patients with MFFs during the initial assessment and treatment stage to reduce morbidity and mortality. The objective of the present study was to systematically review the literature to determine specific MFF situations associated with TBIs and to identify the factors associated with TBIs in patients with MFFs. Read More

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Return to Play Prediction Accuracy of the MLG-R Classification System for Hamstring Injuries in Football Players: A Machine Learning Approach.

Sports Med 2022 May 24. Epub 2022 May 24.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.

Background And Objective: Muscle injuries are one of the main daily problems in sports medicine, football in particular. However, we do not have a reliable means to predict the outcome, i.e. Read More

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Assessment of antimicrobial, cytotoxicity, and antiviral impact of a green zinc oxide/activated carbon nanocomposite.

Sci Rep 2022 May 24;12(1):8774. Epub 2022 May 24.

Chemical and Petrochemical Engineering Department, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, Alexandria, 21934, Egypt.

This work deals with the synthesis of zinc oxide nanoparticles/activated carbon (ZnO NPs/AC) nanocomposites with different weight ratios (3:1, 1:1, and 1:3), where the antimicrobial, antiviral, and cytotoxicity impact of the formulated nanocomposites were evaluated versus the crude ZnO and AC samples. The formula (3:1; designated Z3C1) exhibited the utmost bactericidal effect against Gram positive group, unicellular and filamentous fungi. Regarding Gram negative group, the sample (Z3C1) was remarkably effective against Klebsiella pneumonia, unlike the case of Escherichia coli. Read More

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Enhanced recovery after cardiac surgery under CPB or off pump.

Anaesth Crit Care Pain Med 2022 May 21:101106. Epub 2022 May 21.

Advisory Editor of ACCPM, French Society of Anaesthesia and Intensive Care (SFAR), 74, rue Raynouard, 75016 Paris, France; Caen University Hospital, Anaesthesiology and Critical Care Medicine Department, Caen, France.

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Spectrophotometric determination of Zr(IV), Hg(II) and U(VI) in solution with their analytical applications: Structural characterization and molecular docking of the solid complexes.

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 18;279:121400. Epub 2022 May 18.

Faculty of Science, Chemistry Department, Zagazig University, Zagazig 44519, Egypt. Electronic address:

Spectrophotometry was used to determine trace amounts of Zirconium(IV), Mercury(II) and Uranium(VI) in environmental, biological, pharmaceutical and industrial samples. The determination depend on the complexation reactions between albendazole reagent and metal ions [Zr(IV), Hg(II) and U(VI)] at 555 nm, 485 nm and 510 nm, respectively. The experimental conditions were explored to reach the optimum conditions for albendazole-metal ions interaction, including detection of a suitable wavelength, medium (pH), reagent concentration, surfactants effect, reaction time and temperature. Read More

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Discovery of new drug indications for COVID-19: A drug repurposing approach.

PLoS One 2022 24;17(5):e0267095. Epub 2022 May 24.

GIGA-R Medical Genomics - BIO3 Systems Genomics, University of Liège, Liège, Belgium.

Motivation: The outbreak of coronavirus health issues caused by COVID-19(SARS-CoV-2) creates a global threat to public health. Therefore, there is a need for effective remedial measures using existing and approved therapies with proven safety measures has several advantages. Dexamethasone (Pubchem ID: CID0000005743), baricitinib(Pubchem ID: CID44205240), remdesivir (PubchemID: CID121304016) are three generic drugs that have demonstrated in-vitro high antiviral activity against SARS-CoV-2. Read More

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