4,787 results match your criteria Aquatic Toxicology[Journal]


Zinc pyrithione (ZPT) -induced embryonic toxicogenomic responses reveal involvement of oxidative damage, apoptosis, endoplasmic reticulum (ER) stress and autophagy.

Aquat Toxicol 2022 May 13;248:106195. Epub 2022 May 13.

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211800, China. Electronic address:

Zinc pyrithione (ZPT) is a frequently used organometallic biocide, carrying potentially adverse consequences to multiple species in the environment. Previously we have demonstrated its embryonic, organ developmental and liver metabolic toxicity of zebrafish. However, details of ZPT toxicity during embryogenesis are still limited. Read More

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An integrated biomarker approach: Non-monotonic responses to cadmium exposure in the suckermouth catfish Hypostomus plecostomus.

Aquat Toxicol 2022 May 7;248:106193. Epub 2022 May 7.

Department of Biological Sciences, Universidad de Bogotá Jorge Tadeo Lozano, Carrera 4 No. 22-61, Bogota, Colombia.

Environmental risk assessment in aquatic ecosystems typically uses biomarkers to detect interactions between potential hazards and biological systems. Next to knowing environmental contaminant levels in tissues and the environment, it is important to link to potentially deleterious effects at higher levels of biological organization such as biochemistry, physiology, and overall health status. In this laboratory study we assessed the toxicity of waterborne cadmium (Cd) over an exposure range of 0 - 100 µg l for nine days to the loricariid suckermouth catfish Hypostomus plecostomus. Read More

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Biomolecular modifications in the sacfry of Mogurnda adspersa in response to copper stress.

Aquat Toxicol 2022 Apr 27;248:106179. Epub 2022 Apr 27.

Centre for Freshwater Ecosystems, Department of Ecology, Environment and Evolution (DEEE), La Trobe University, Albury/Wodonga Campus, VIC, 3690, Australia.

Copper (Cu) is one of the most harmful contaminants in fresh-water systems. Fish larvae such as sacfry are particularly vulnerable to metals such as copper (Cu) due to a less-developed excretory organ system and permeable skin that can absorb metals directly from the water. However, the sublethal effects of metals on this life stage are not well understood. Read More

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mRNA-miRNA sequencing reveals mechanisms of 2,2'-dipyridyl disulfide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus).

Aquat Toxicol 2022 May 7;248:106191. Epub 2022 May 7.

College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, China. Electronic address:

This study was conducted to evaluate the thyroid-disrupting effects of 2,2'-dipyridyl disulfide using Japanese flounder (Paralichthys olivaceus) as an animal model and to reveal the underlying mechanisms from the perspective of miRNA-mRNA interactions. The results indicated that 2,2'-dipyridyl disulfide exposure decelerated the metamorphic progress of P. olivaceus, suggesting its thyroid-disrupting property as an antagonist. Read More

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Long-term exposure of zebrafish to bisphenol F: Adverse effects on parental reproduction and offspring neurodevelopment.

Aquat Toxicol 2022 May 9;248:106190. Epub 2022 May 9.

Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing 210042, China. Electronic address:

Bisphenol F (BPF), an alternative to bisphenol A (BPA) has potential endocrine and reproductive toxicity; however, the effects of environmental concentrations of BPF on the reproductive and developmental toxicity of offspring following parental exposure to BPF remain unclear. In the present study, the effects of life-cycle BPF exposure at environmental concentrations on zebrafish reproduction, offspring growth, and development were investigated. The results showed that the life-cycle of BPF exposure significantly elevated oxidative stress levels, increased gonadal apoptosis, and reduced zebrafish (F0) spawning. Read More

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Widespread alterations upon exposure to the estrogenic endocrine disruptor ethinyl estradiol in the liver proteome of the marine male fish Cyprinodon variegatus.

Aquat Toxicol 2022 May 4;248:106189. Epub 2022 May 4.

Centro de Investigación Mariña da Universidade de Vigo (CIM-UVigo), Vigo, Galicia, Spain; Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain. Electronic address:

Quantitative proteomic changes in the liver of adult males of Sheepshead minnow (Cyprinodon variegatus) upon exposure to ethinyl estradiol (EE2) were assessed to provide an advanced understanding of the metabolic pathways affected by estrogenic endocrine disruption in marine fish, and to identify potential novel molecular biomarkers for the environmental exposure to estrogens. From a total of 3188 identified protein groups (hereafter proteins), 463 showed a statistically significant difference in their abundance between EE2 treatment and solvent control samples. The most affected biological processes upon EE2 exposure were related to ribosomal biogenesis, protein synthesis and transport of nascent proteins to endoplasmic reticulum, and nuclear mRNA catabolism. Read More

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Observed and predicted embryotoxic and teratogenic effects of organic and inorganic environmental pollutants and their mixtures in zebrafish (Danio rerio).

Aquat Toxicol 2022 Apr 25;248:106175. Epub 2022 Apr 25.

Man-Technology-Environment Research Centre (MTM), School of Science and Technology, Örebro University, Fakultetsgatan 1, S-701 82 Örebro, Sweden.

Risk assessment of chemicals is still primarily focusing on single compound evaluation, even if environmental contamination consists of a mixture of pollutants. The concentration addition (CA) and independent action (IA) models have been developed to predict mixture toxicity. Both models assume no interaction between the components, resulting in an additive mixture effect. Read More

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Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish.

Aquat Toxicol 2022 Apr 21;248:106177. Epub 2022 Apr 21.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.

Synthetic progestins levonorgestrel (LNG) and dydrogesterone (DDG) are frequency detected in surface water. Combined effects of LNG and DDG on gonad differentiation are similar to LNG single exposure in juvenile zebrafish. However, LNG and DDG mixtures have stronger effects on spermatogenesis in testes of adult zebrafish, which show variable at different life stage. Read More

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Gut microbiota of Anabas testudineus (Bloch, 1792) in the e-waste dismantling region: In situ status and relationship with internal metal burden.

Aquat Toxicol 2022 Apr 12;248:106171. Epub 2022 Apr 12.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Due to the production of large quantities of electronic waste (e-waste), unsafe dismantling has caused serious pollution as well as toxicological impacts on both wildlife and humans. As an important aspect of physiology and health, the wildlife's gut microbiota and its changes induced by pollution have been recruiting increasing concerns. To reveal the gut microbiota-related ecotoxicology induced by e-waste dismantling, this study resolves the gut microbiota profile of Anabas testudineus, a native highly adapted nonmodel fish under the in situ exposure, and reveals whether and how the microbiota was altered. Read More

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Exposure of Anopheles gambiae larvae to a sub-lethal dose of an agrochemical mixture induces tolerance to adulticides used in vector control management.

Aquat Toxicol 2022 Apr 26;248:106181. Epub 2022 Apr 26.

Univ. Grenoble-Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, 38000 Grenoble, France. Electronic address:

The heavy use of pesticides in agricultural areas often leads to the contamination of nearby mosquito larvae breeding sites. Exposure to complex mixtures of agrochemicals can affect the insecticide sensitivity of mosquito larvae. Our study objective was to determine whether agrochemical residues in Anopheline larval breeding sites can affect the tolerance of adults to commonly used adulticides. Read More

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Cadmium impairs zebrafish swim bladder development via ROS mediated inhibition of the Wnt / Hedgehog pathway.

Aquat Toxicol 2022 Jun 25;247:106180. Epub 2022 Apr 25.

Key Laboratory of Tropical Marine Bio-resourcesand Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou 511458, China; Institution of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, Guangzhou 510301, China. Electronic address:

The posterior swim bladder is an important organ in teleost fishes, that primarily maintains buoyancy and motility for swimming and survival. In this study, we examined the molecular mechanisms of the toxicity of cadmium (Cd) on the early development of the swim bladder in zebrafish. Embryonic Cd exposure resulted in the non-inflation of the swim bladder when the ambient Cd concentration was greater than or equal to 0. Read More

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What contributes to the metal-specific partitioning in the chub-acanthocephalan system?

Aquat Toxicol 2022 Jun 25;247:106178. Epub 2022 Apr 25.

Department of Aquatic Ecology and Centre for Water and Environmental Research (ZWU), Faculty of Biology, University of Duisburg-Essen, D-45141 Essen, Germany.

Physiologically based pharmacokinetic (PBPK) models have been applied to simulate the absorption, distribution, metabolism, and elimination of various toxicants in fish. This approach allows for considering metal accumulation in intestinal parasites. Unlike "semi" physiologically-based models developed for metals, metal accumulation in fish was characterised based on metal-specific parameters (the fraction in blood plasma and the tissue-blood partition coefficient) and physiological characteristics of the fish (the blood flow and the tissue weight) in our PBPK model. Read More

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Toxicity assessment of TiO-conjugated Carbon-based nanohybrid material on a freshwater bioindicator cladoceran, Daphnia magna.

Aquat Toxicol 2022 Jun 19;247:106176. Epub 2022 Apr 19.

Institute for Nanotechnology and Water Sustainability, College of Science, Engineering and Technology, University of South Africa, Florida Science Campus, P/Bag X6, Roodepoort 1709, South Africa. Electronic address:

The application of nanocomposite materials fabricated from titanium dioxide nanoparticles (TiO NPs) and different carbon (C) allotropes have gained popularity in water treatment applications due to their synergistic properties. Studies to date have focused on simple forms of nanomaterials (NMs), however, with the technology development, there is a dramatic increase in production and application of these complex NMs which could result in toxicological impacts on organisms when released into aquatic environments. This raises serious concerns about their safety and the need to ascertain their potential adverse effects on aquatic organisms. Read More

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Effect of sea lice chemotherapeutant hydrogen peroxide on the photosynthetic characteristics and bleaching of the coralline alga Lithothamnion soriferum.

Aquat Toxicol 2022 Jun 17;247:106173. Epub 2022 Apr 17.

Institute of Marine Research, Nordnesgaten 50, Bergen 5005, Norway.

The proliferation of sea lice (Lepeophtheirus salmonis) represents a major challenge for the salmonid aquaculture industry in Norway. Hydrogen peroxide (HO) is a chemotherapeutant frequently used on Norwegian farms, however, its toxicity to non-target benthic species and habitats remains poorly understood. Maerl beds are constructed by the accumulation of non-geniculate coralline algae and provide important ecological functions. Read More

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Molting enhances internal concentrations of fipronil and thereby decreases survival of two estuarine resident marine crustaceans.

Aquat Toxicol 2022 Jun 14;247:106172. Epub 2022 Apr 14.

Environment Conservation Division, Fisheries Technology Institute, National Research and Development Agency, Japan Fisheries Research and Education Agency, 2-17-5 Maruishi, Hatsukaichi, Hiroshima 739-0452, Japan.

In aquatic arthropods, molting is a pivotal physiological process for normal development, but it may also expose them to higher risks from xenobiotics, because the organism may take up additional water during that time. This study aimed to assess the effects of molting on bioconcentration and survival after 96-h exposure to insecticide fipronil with or without oxygenase (CYP450s) inhibitor piperonyl butoxide (PBO) of two estuarine resident marine crustacean species: the sand shrimp Crangon uritai and the kuruma prawn Penaeus japonicus, with 96-h LC value of fipronil = 2.0 µg/L and 0. Read More

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Insights into the mechanisms of tris(2-chloroethyl) phosphate-induced growth inhibition in juvenile yellow catfish Pelteobagrus fulvidraco.

Aquat Toxicol 2022 Jun 10;247:106170. Epub 2022 Apr 10.

Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519000, China. Electronic address:

With the gradual elimination of brominated flame retardants (BFRs), the production and application of tris (2-chloroethyl) phosphate (TCEP), as a substitute of BFRs, has increased greatly. The objective of the present study was to comprehensively explore the potential adverse effects of TCEP on fish growth and the possible underlying mechanisms. To this end, juvenile yellow catfish (Pelteobagrus fulvidraco) were exposed to environmentally relevant concentrations of TCEP (0, 1, 10 and 100 µg/L) for 30 days. Read More

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The toxicokinetics of bisphenol A and its metabolites in fish elucidated by a PBTK model.

Aquat Toxicol 2022 Jun 18;247:106174. Epub 2022 Apr 18.

Experimental Toxicology and Modeling Unit, INERIS, UMR-I 02 SEBIO, Verneuil en Halatte 65550, France. Electronic address:

Bisphenol A (BPA) is a chemical of major concern due to its endocrine disrupting function, high production volume, and persistence in the aquatic environment. Consequently, organisms such as fish are subject to chronic exposure to BPA. However, physiologically-based toxicokinetic (PBTK) models, which are valuable tools to improve the understanding of a chemical's fate in an organism, have never been specifically adapted to model BPA toxicokinetics (TK) in fish. Read More

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Potential estrogenic background in aquatic laboratory cultivations.

Aquat Toxicol 2022 Jun 10;247:106169. Epub 2022 Apr 10.

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, CZ-62500 Brno, Czech Republic. Electronic address:

Aquatic biotests are important tools targeting various effects in ecotoxicology, including endocrine disruption. Unintentional exposure of bioassay organisms to endocrine disruptors during cultivation or testing may interfere with assessed endpoints. We illustrate this issue on the example of laboratory phytoplankton cultivation, where possible sources of estrogenic compounds have been revealed. Read More

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Toxicological assessment of cadmium-containing quantum dots in developing zebrafish: Physiological performance and neurobehavioral responses.

Aquat Toxicol 2022 Jun 5;247:106157. Epub 2022 Apr 5.

Department of Biology, York University, Toronto, ON, Canada. Electronic address:

The present research investigated the effects of exposure to sublethal concentrations of cadmium selenide/zinc sulfide (CdSe/ZnS)-containing quantum dots (QDs; 0 - 100 µg/L QDs) on the neurophysiological performance of developing zebrafish (Danio rerio). The results suggested that exposure to CdSe QDs for 5 days increased the whole-body content of Cd without affecting the general physiological conditions of larvae. Interestingly, CdSe QD exposure reduced swimming distance but increased swimming velocity of larvae, suggesting that the exposure may lead to burst/episodic swimming. Read More

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Aspirin inhibits stem cell proliferation during freshwater Dugesia japonica regeneration by STAT3/SOX2/OCT4 signaling pathway.

Aquat Toxicol 2022 Jun 10;247:106158. Epub 2022 Apr 10.

College of Life Science, Henan Normal University, Xinxiang, 453007 Henan, China.

As a widely used drug in clinical practice, aspirin has a large number of residual drugs and metabolites discharged into the environment during the pharmaceutical process or after taking the drug. Aspirin content and its metabolite, salicylic acid, have been reported and detected in several river water samples and municipal wastewaters. However, little is known about the toxicity mechanisms of this drug in aquatic invertebrates. Read More

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Inhibitory effects of estrogenic endocrine disrupting chemicals on fin regeneration in zebrafish are dependent on estrogen receptors.

Aquat Toxicol 2022 Jun 5;247:106156. Epub 2022 Apr 5.

College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

For fish and other aquatic organisms, disrupting their capacity for repair and regeneration will reduce their quality of life and survivorship in the wild. Studies have shown that 17α-ethinylestradiol (EE2), a synthetic estrogenic endocrine disrupting chemical (EEDC), can inhibit caudal fin regeneration in larval zebrafish following fin amputation. However, whether the inhibitory effects of EE2 are dependent on estrogen receptor (ER) remains unknown. Read More

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Diluted bitumen-induced alterations in aerobic capacity, swimming performance, and post-exercise recovery in juvenile sockeye salmon (Oncorhynchus nerka).

Aquat Toxicol 2022 Jun 25;247:106150. Epub 2022 Mar 25.

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada. Electronic address:

The transportation of heavy crudes such as diluted bitumen (dilbit) sourced from Canadian oil sands through freshwater habitat requires the generation of information that will contribute to risk assessments, spill modelling, management, and remediation for the protection of aquatic organisms. Juvenile sockeye salmon (Oncorhynchus nerka) were exposed acutely (96 h) or subchronically (28 d) to the water-soluble fraction (WSFd) of Cold Lake Blend dilbit at initial total polycyclic aromatic compound (TPAC) concentrations of 0, 13.7, 34. Read More

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UV-filter octyl methoxycinnamate causes reproductive toxicity associated with germline apoptosis and vitellogenin decrease in Caenorhabditis elegans.

Aquat Toxicol 2022 Jun 23;247:106149. Epub 2022 Mar 23.

Institute of Food Safety and Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei 100, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, No. 17, Xuzhou Rd., Taipei 100, Taiwan. Electronic address:

Octyl methoxycinnamate (OMC) is a common UV filter found in personal care products such as sunscreen and cosmetics. However, OMC's presence in wastewater has raised concerns that it could potentially pollute aquatic ecosystems because of its limited biodegradability and its estrogenic disrupting properties. In this study, we investigated the environmental toxicity of OMC and its potential biomarkers using the nematode Caenorhabditis elegans. Read More

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Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae.

Aquat Toxicol 2022 May 29;246:106154. Epub 2022 Mar 29.

Key Laboratory of Environmental Nanotechnology and Health Effects, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan 430056, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Bisphenol A (BPA) analogues are gradually replacing BPA in the plastics industry. Whether these alternatives are indeed safer than BPA itself, however, remains unclear. Here, we studied the toxicity of BPA and six of its alternatives-BPB, BPC, BPE, BPF, BPAF, and BPAP-using zebrafish embryos/larvae. Read More

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Teratogenicity of retinoids detected in surface waters in zebrafish embryos and its predictability by in vitro assays.

Aquat Toxicol 2022 May 27;246:106151. Epub 2022 Mar 27.

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Kamenice, Brno 62500 , Czech Republic. Electronic address:

Retinoids are newly detected compounds in aquatic ecosystems associated with cyanobacterial water blooms. Their potential health risks are only scarcely described despite numerous detections of all-trans retinoic acid (ATRA) and its derivatives in the environment. Besides the known teratogen ATRA there is only little or no information about their potency and namely their effects in vivo. Read More

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Effects of trace elements contaminations on the larval development of Paracentrotus lividus using an innovative experimental approach.

Aquat Toxicol 2022 May 27;246:106152. Epub 2022 Mar 27.

Université de Corse, UMR CNRS 6134 Sciences pour l'Environnement, 20250 Corte, France; Université de Corse, UAR CNRS 3514 Stella Mare, 20620 Biguglia, France.

Several experiments were performed using larvae of Paracentrotus lividus (Lamarck, 1816) in order to determine the consequences of different chronic contamination with mixtures of (i) fifteen trace elements from concentrations measured in the world ocean seawater, and (ii) seven trace elements from contamination resulting from mining. To predict the impact of increased marine pollution, higher concentrations were also used. These bioassays were conducted using spawners collected from Calvi (reference site, Corsica), and Albo (mining area, Corsica). Read More

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Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells.

Aquat Toxicol 2022 May 28;246:106153. Epub 2022 Mar 28.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Overuse of acetochlor pollutes soil and rivers, causing threats to the ecosystem. Studies found that acetochlor exposure could damage multiple organs and tissues in fish and mammal. Tea polyphenols (TP), a natural antioxidant that extracted from tea, has been widely used in food and feed additions. Read More

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Chemoprotection mediated by açaí berry (Euterpe oleracea) in white shrimp Litopenaeus vannamei exposed to the cyanotoxin saxitoxin analyzed by in vivo assays and docking modeling.

Aquat Toxicol 2022 May 22;246:106148. Epub 2022 Mar 22.

Graduate Program in Aquiculture, Institute of Oceanography (IO), Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil; Laboratory of Functional Biochemistry of Aquatic Organisms (BIFOA), FURG, Rio Grande, RS, Brazil; Institute of Biological Sciences (ICB), FURG, Rio Grande, RS, Brazil. Electronic address:

Saxitoxin (STX) is a neurotoxic cyanotoxin that also generate reactive oxygen species, leading to a situation of oxidative stress and altered metabolism. The Amazonian fruit açaí Euterpe oleracea possesses a high concentration of antioxidant molecules, a fact that prompted us to evaluate its chemoprotection activity against STX toxicity (obtained from samples of Trichodesmium sp. collected in the environment) in the shrimp Litopenaeus vannamei. Read More

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Exposure to clothianidin and predators increases mortality for heptageniidae.

Aquat Toxicol 2022 May 18;246:106146. Epub 2022 Mar 18.

Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907 USA.

Neonicotinoids are a class of insecticide with global impacts on natural environments. Due to their high solubility, they are frequently found in stream ecosystems where they have the potential to impact non-target biota. While environmental concentrations are generally below lethal levels for most organisms, there are concerns that sublethal exposures can impact aquatic insects, particularly mayflies, which are highly sensitive to neonicotinoids. Read More

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