1,058,345 results match your criteria Applied radiation and isotopes : including data instrumentation and methods for use in agriculture industry and medicine[Journal]


Catalytic activity of alkali metal cations for chemical oxygen reduction reaction in a biphasic liquid system probed by scanning electrochemical microscopy.

Chemistry 2020 May 27. Epub 2020 May 27.

Carl v. Ossietzky University of Oldenburg, Institute of Chemistry, Carl von Ossietzky Str. 9-11 W3 1-105, 26111, Oldenburg, GERMANY.

Chemical reduction of dioxygen in organic solvents for the production reactive oxygen species or the concomitant oxidation of organic substrates can be enhanced in by separation of products and educts in biphasic liquid systems. Here, we study the coupled electron and ion transfer processes as well as reagent fluxes across the liquid-liquid interface for the chemical reduction of dioxygen by decamethylferrocene (DMFc) in a dichloroethane-based organic electrolyte forming an interface with an aqueous electrolyte containing alkali metal ions. This interface is stabilized at the orifice of a pipette, across which a Galvani potential difference is externally applied and precisely adjusted in order to enforce the transfer of different alkali metal ions from the aqueous to the organic electrolyte. Read More

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http://dx.doi.org/10.1002/chem.202001967DOI Listing

Mouthguard use and TMJ injury prevention with different occlusions: A three-dimensional finite element analysis.

Dent Traumatol 2020 May 27. Epub 2020 May 27.

Department of Oral Cell Biology and Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU UniversityAmsterdam, Amsterdam, The Netherlands.

Background/aims: There is a lack of data regarding the temporomandibular joint's mechanical response during an impact to the orofacial region. The aim of this study was to analyze the biomechanical effects of wearing a mouthguard (MG) on the impact response of the mandibular condyle and articular disc according to the type of occlusion. The hypothesis was that the MG would minimize the effect in those structures, regardless of the occlusion type. Read More

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http://dx.doi.org/10.1111/edt.12577DOI Listing

Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma.

Hepatology 2020 May 27. Epub 2020 May 27.

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom.

Background & Aims: Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC). However, the metabolic control of these processes is not fully understood. In order to capture the metabolic signature of proliferating hepatocytes, we applied state-of-the-art systems biology approaches to models of liver regeneration, pharmacologically- and genetically-activated cell proliferation, and HCC. Read More

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http://dx.doi.org/10.1002/hep.31391DOI Listing

Effects of Photobiomodulation with Low-Level Laser Therapy in Burning Mouth Syndrome: A randomized clinical trial.

Oral Dis 2020 May 27. Epub 2020 May 27.

Department of Dental Clinical Specialties, ORALMED research group, School of Dentistry, Complutense University, Madrid, Spain.

Background: Photobiomodulation has proven to be effective in different painful conditions.

Objectives: To assess the effect of photobiomodulation for pain management in burning mouth syndrome (BMS) patients, besides analysing the impact on different aspects of quality of life.

Methods: A randomized, single blind, clinical trial was performed among 20 patients with BMS. Read More

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http://dx.doi.org/10.1111/odi.13443DOI Listing

Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications.

Clin Pharmacol Ther 2020 May 27. Epub 2020 May 27.

Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

There is an increasing interest in transporter induction (i.e., decreased systemic drug exposure due to increased efflux-limited absorption or transporter-mediated clearance) as a mechanism of drug-drug interactions (DDIs), although evidence of clinical relevance is still evolving. Read More

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http://dx.doi.org/10.1002/cpt.1916DOI Listing

Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota.

J Food Sci 2020 May 27. Epub 2020 May 27.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China.

Cancer represents a major disease burden worldwide. Despite continuous advances obtained in medical therapies recently, resistance to standard drugs and adverse effects still represent important causes of therapeutic failure. There is growing evidence that the gut microbiota can affect the response to chemo- and immunotherapeutic drugs by modulating efficacy and/or toxicity, and diet is the most important factor affecting the gut microbiota. Read More

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http://dx.doi.org/10.1111/1750-3841.15134DOI Listing

How to Transition from Single Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.

Clin Pharmacol Ther 2020 May 27. Epub 2020 May 27.

Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA.

There have been significant advancements in precision medicine and approaches to medication selection based on pharmacogenetic results. With the availability of direct-to-consumer genetic testing and growing awareness of genetic inter-individual variability, patient demand for more precise, individually tailored drug regimens is increasing. The University of Florida (UF) Health Precision Medicine Program (PMP) was established in 2011 to improve integration of genomic data into clinical practice. Read More

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http://dx.doi.org/10.1002/cpt.1912DOI Listing

Socioeconomic disadvantages over the life-course and their influence on obesity among older Hong Kong Chinese adults.

Eur J Public Health 2020 May 27. Epub 2020 May 27.

The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.

Background: The life-course perspective on socioeconomic inequality in health is a burgeoning field of research. Nonetheless, the three classic life-course models (i.e. Read More

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http://dx.doi.org/10.1093/eurpub/ckaa072DOI Listing

Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion.

Clin Chem 2020 May 27. Epub 2020 May 27.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

Background: Most existing DNA methylation-based methods for detection of circulating tumor DNA (ctDNA) are based on conversion of unmethylated cytosines to uracil. After conversion, the 2 DNA strands are no longer complementary; therefore, targeting only 1 DNA strand merely utilizes half of the available input DNA. We investigated whether the sensitivity of methylation-based ctDNA detection strategies could be increased by targeting both DNA strands after bisulfite conversion. Read More

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http://dx.doi.org/10.1093/clinchem/hvaa100DOI Listing

New insights in the use of a strong cationic resin in dye adsorption.

Water Sci Technol 2020 Feb;81(4):773-780

Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, USACH, Casilla 40, Correo 33, Santiago, Chile E-mail:

The adsorption of methyl orange (MO) in aqueous solution was evaluated using a cationic polymer (Amberlite IRA 402) in batch experiments under different experimental variables such as amount of resin, concentration of MO, optimum interaction time and pH. The maximum adsorption capacity of the resin was 161.3 mg g at pH 7. Read More

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http://dx.doi.org/10.2166/wst.2020.158DOI Listing
February 2020

Removal of a mixture of pharmaceuticals sulfamethoxazole and diclofenac from water streams by a polyamide nanofiltration membrane.

Water Sci Technol 2020 Feb;81(4):732-743

University of Coimbra, CIEPQPF, Department of Chemical Engineering, Rua Sílvio Lima - Pólo II, Pinhal de Marrocos, 3030-790 Coimbra, Portugal E-mail:

Wastewater treatment plants are not specially designed to remove pharmaceutically active compounds (PhACs), since these substances are toxic and bio-refractory. This paper aims to investigate and optimize the performance of the Trisep TS80 nanofiltration (NF) membrane for the removal of a mixture of two of the most detected PhACs in municipal wastewaters worldwide, sulfamethoxazole and diclofenac. Several NF tests were carried out to study the rejections of these contaminants both spiked in demineralized water, filtrated water taken from Mondego River and secondary effluent coming from a municipal wastewater treatment plant. Read More

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http://dx.doi.org/10.2166/wst.2020.166DOI Listing
February 2020

Does influent C/N ratio affect pollutant removal and greenhouse gas emission in wastewater ecological soil infiltration systems with/without intermittent aeration?

Water Sci Technol 2020 Feb;81(4):668-678

College of Life Science, Shenyang Normal University, Shenyang 110034, China E-mail:

Wastewater ecological soil infiltration system (WESIS) is a land treatment technology for decentralized wastewater treatment that has been applied all over the world. In this study, the pollutant removal, emission of greenhouse gases (GHGs) and functional gene abundances with different influent C/N ratios were evaluated in WESISs with/without intermittent aeration. Intermittent aeration and influent C/N ratio affect pollutant removal and GHG emission. Read More

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http://dx.doi.org/10.2166/wst.2020.141DOI Listing
February 2020

Theoretical investigation of antiferromagnetic skyrmions in a triangular monolayer.

J Phys Condens Matter 2020 May 27. Epub 2020 May 27.

Peter Gruenberg Institut and Institute for Advanced Simulation, Forschungszentrum Juelich, D-52425 Juelich, Juelich, GERMANY.

The chiral spin textures of a two-dimensional (2D) triangular system, where both antiferromagnetic (AF) Heisenberg exchange and chiral Dzyaloshinsky-Moriya interactions co-exist, are investigated numerically with an optimized quantum Monte Carlo method based on mean-field theory. We find that: helical, skyrmionic and vortical AF crystals can be formed when an external magnetic field is applied perpendicular to the 2D monolayer; the sizes of these skyrmions and vortices change abruptly at several critical points of the external magnetic field; each of these AF crystals can be decomposed into three periodical ferromagnetic sublattices. The quantum ingredient implemented into the theoeretical framework helps to track the existence of AF skyrmion lattices down to low temperatures. Read More

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http://dx.doi.org/10.1088/1361-648X/ab96efDOI Listing

Material assignment for proton range prediction in Monte Carlo patient simulations using stopping-power datasets.

Phys Med Biol 2020 May 27. Epub 2020 May 27.

Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, GERMANY.

For each institute, the selection and calibration of the most suitable approach to assign material properties for Monte Carlo (MC) patient simulation in proton therapy is a major challenge. Current conventional approaches based on computed tomography (CT) depend on CT acquisition and reconstruction settings. This study proposes a material assignment approach, referred to as MATA (erialssignment), which is independent of CT scanner properties and, therefore, universally applicable by any institute. Read More

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http://dx.doi.org/10.1088/1361-6560/ab9702DOI Listing

Exploiting the intrinsic deformation of a prosthetic foot to estimate the center of pressure and ground reaction force.

Bioinspir Biomim 2020 May 27. Epub 2020 May 27.

The Robotics Research Lab, University of Kaiserslautern, Postbox 3049, Kaiserslautern, 67653, GERMANY.

The properties of the foot deployed in a bipedal robot that targets the rendering of a human-like dynamic gait are crucial. Firstly, it has to implement a set of mechanical mechanisms/properties that improve the efficiency of the locomotion. Secondly, it has to integrate a sensory system that captures the interaction with the ground with suitable precision. Read More

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http://dx.doi.org/10.1088/1748-3190/ab96d7DOI Listing

Reducing MRI RF-induced heating for the external fixation using capacitive structures.

Phys Med Biol 2020 May 27. Epub 2020 May 27.

University of Houston Cullen College of Engineering, Houston, Texas, 77204-4007, UNITED STATES.

This paper presents a generic method to reduce the radiofrequency (RF) induced heating of external fixation devices during magnetic resonance imaging (MRI) procedure. A simplified equivalent circuit model was developed to illustrate the interactions between the external fixation device and the MRI RF field. Carefully designed mechanical structures, which utilize capacitive reactance from the circuit model, were applied to the external fixation devices to mitigate the coupling between the external fixation device and the MRI RF field for RF-induced heating reduction. Read More

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http://dx.doi.org/10.1088/1361-6560/ab9706DOI Listing

Single spectrum three-material decomposition with grating-based x-ray phase-contrast CT.

Phys Med Biol 2020 May 27. Epub 2020 May 27.

Physics, Technische Universitat Munchen, Munchen, Bayern, GERMANY.

Grating-based X-ray phase-contrast imaging provides three simultaneous image channels originating from a single image acquisition. While the phase signal provides direct access to the electron density in tomography, there is additional information on sub-resolutional structural information which is called dark-field signal in analogy to optical microscopy. The additional availability of the conventional attenuation image qualifies the method for implementation into existing diagnostic routines. Read More

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http://dx.doi.org/10.1088/1361-6560/ab9704DOI Listing

New prediction tool-LIST-with improved prediction accuracy for 30-day readmission rates in patients with head and neck cancer after major cancer surgery.

Oral Oncol 2020 May 24;108:104772. Epub 2020 May 24.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Department of Otolaryngology, Head and Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan. Electronic address:

We hope to establish a new readmission prediction score for patients with head and neck cancer (HNC) after major cancer surgery. A retrospective cohort study was conducted from the clinical and cancer registry data at Kaohsiung Veterans General Hospital. We included the data of patients with newly diagnosed HNC who underwent surgical treatment between Nov 2010 and Dec 2017. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104772DOI Listing

Determination of the most effective enhancement process for latent fingermarks on Clydesdale Bank and Royal Bank of Scotland £5 and £10 polymer banknotes.

Forensic Sci Int 2020 May 13;312:110334. Epub 2020 May 13.

SPA Forensic Services, Scottish Crime Campus, Craignethan Drive, Gartcosh, G69 8AE, United Kingdom. Electronic address:

Fingermarks are commonly found at crime scenes and can be used to link an individual to an object and/or place. One common evidence type regularly encountered in the course of a criminal investigation is banknotes, and the recovery of fingermarks from these notes can give an indication of who has handled them. This study was carried out in order to determine the most effective sequential processing techniques for recovering latent fingermarks on the new £5 and £10 Clydesdale Bank and Royal Bank of Scotland polymer banknotes. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110334DOI Listing

A LC-MS/MS method for therapeutic drug monitoring of sorafenib, regorafenib and their active metabolites in patients with hepatocellular carcinoma.

J Pharm Biomed Anal 2020 May 24;187:113358. Epub 2020 May 24.

Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via F. Gallini 2, 33081 Aviano, Italy.

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous quantification of sorafenib (SORA), its N-oxide active metabolite and of regorafenib (REGO) and its two active metabolites regorafenib N-oxide and N-desmethyl regorafenib N-oxide in hepatocellular carcinoma patients' plasma. A proper analytes' separation was obtained with Synergi Fusion RP column (4 μm, 80 Å, 50 × 2.0 mm) using a gradient elution of 10 mM ammonium acetate with 0. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113358DOI Listing

Updating the European Pharmacopoeia impurity profiling method for terazosin and suggesting alternative columns.

J Pharm Biomed Anal 2020 May 19;187:113371. Epub 2020 May 19.

Egis Pharmaceuticals Plc., Keresztúri út 30-38, 1106 Budapest, Hungary. Electronic address:

This work was motivated by the demand of European Directorate for the Quality of Medicines and HealthCare (EDQM). A new liquid chromatographic (LC) method was developed for terazosin impurity profiling to replace the old European Pharmacopoeia (Ph. Eur. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113371DOI Listing

Mentalexo approach for diagnosis of psychiatric disorders.

Med Hypotheses 2020 May 12;143:109823. Epub 2020 May 12.

Histology and Embriology, Public Health Residency, Marmara University School of Medicine Department of Public Health, Turkey.

Introduction: Psychiatric disorders cause a high burden of disease and disability for the society. Liquid biopsies provide potent opportunities for screening programs, diagnosis, prognostic stratification and treatment monitorization. Previously, the liquid biopsy studies were mainly focused on the several malignancies without proper screen methods, but this approach has also a strong potential for decreasing disease burden in CNS pathologies. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109823DOI Listing

Body image and body change behaviors associated with orthorexia symptoms in males.

Body Image 2020 May 24;34:46-50. Epub 2020 May 24.

Department of Applied Psychology, Northeastern University, Boston, United States; Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHRU, Montpellier, France. Electronic address:

In recent years, Orthorexia Nervosa has received increasing attention as a form of restrictive disordered eating driven by concerns related to "healthy eating" as opposed to weight and shape concerns. To date, however, data on the correlates of orthorexia in men are lacking, particularly pertaining to the relationship between orthorexia and muscularity-related dimensions. A sample of 103 (M = 19. Read More

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http://dx.doi.org/10.1016/j.bodyim.2020.05.003DOI Listing

DFT calculations and POM analyses of cytotoxicity of some flavonoids from aerial parts of Cupressus sempervirens: Docking and identification of pharmacophore sites.

Bioorg Chem 2020 Apr 25;100:103850. Epub 2020 Apr 25.

Ibn Zohr University, Faculty of Sciences, B.P. 8106, 80090 Agadir, Morocco. Electronic address:

Two known polyphenols named apigenin 7-O-β-d-glucopyranoside (S1) and querctine-3-O-glucoside (S2), along with another two new compounds apigenin 4'-geranyl-8-glucopyranosyl-7-O-α-glucopyranoside (S3) and apigenin 4'-pernyl-8-glucopyranosyl -7-O-α-glucopyranoside (S4), were isolated from the leaves of Cupressus sempervirens. Structure elucidation of the isolated polyphenols was established on the basis of detailed spectroscopic analysis like 1D and 2D NMR analyses including H NMR, C NMR, COSY, DEPT, HMQC, UV, and Electron Spray Ionization Mass Spectroscopy (ESI-MS). Density Functional Theory (DFT) of computational, Petra/Osiris/Molinspiration (POM), and docking analyses methods were applied in the structural validation of new isolated compounds. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103850DOI Listing

The potential roles of Von Willebrand factor and neutrophil extracellular traps in the natural history of hypertrophic and hypertensive cardiomyopathy.

Thromb Res 2020 May 7;192:78-87. Epub 2020 May 7.

Division of Cardiovascular Health and Disease, Heart, Lung and Blood Institute, University of Cincinnati College of Medicine, United States of America.

Inflammation is often applied broadly to human disease. Despite its general familiarity, inflammation is highly complex. There are numerous injurious, immune and infectious determinants, functional elements and signaling pathways, ranging from genetic to epigenetic, environmental, racial, molecular and cellular that participate in disease onset and progression, phenotypic heterogeneity, and treatment selection and response. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.05.003DOI Listing

One-step ultrasonic synthesis of Co/Ni-catecholates for improved performance in oxygen reduction reaction.

Ultrason Sonochem 2020 May 19;67:105179. Epub 2020 May 19.

School of Science, China University of Geosciences (Beijing), Beijing 100083, People's Republic of China. Electronic address:

The inherent periodically arranged M-N, M-S and M-O units (M are usually Fe, Co, Ni, etc.) in metal-organic frameworks (MOFs) can be promising active centers in electrocatalysis. In previous studies, MOFs were usually constructed by energy-consuming hydro- or solvo-thermal reactions. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105179DOI Listing

Combined effect of physicochemical factors on the retention and transport of g-CN in porous media.

Chemosphere 2020 May 20;256:127100. Epub 2020 May 20.

College of Agricultural Science and Engineering, Hohai University, Nanjing, 210098, China. Electronic address:

The environmental behaviors of graphitic carbon nitride (g-CN) have drawn increasing attention in recent. Understanding the fate and transport of g-CN in porous media is necessary for evaluating its environmental risks. Column experiments were used in this study to investigate the combined effect of ionic strength (IS) and other common physicochemical factors (i. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127100DOI Listing

The potential role of clock genes in children attention-deficit/hyperactivity disorder.

Sleep Med 2020 Mar 5;71:18-27. Epub 2020 Mar 5.

Department of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, Lanzhou, Gansu, PR China.

Background: Attention deficit/ hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder and is thought to be associated with circadian system.

Methods: We performed a pathway-based study to test individual single nucleotide polymorphisms (SNPs) and the overall evidence of genetic polymorphisms involved in the circadian pathway in association with children ADHD susceptibility among a Chinese population. A community-based case-control study was conducted among Chinese children, and 168 ADHD patients and 233 controls were recruited using a combination diagnosis based on the diagnostic and statistical manual of mental disorders iv (DSM-IV) ADHD rating scale, Swanson, Nolan, and Pelham rating scale (SNAP-IV) rating scale, and semi-structured clinical interview. Read More

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http://dx.doi.org/10.1016/j.sleep.2020.02.021DOI Listing

Kinematic changes in patients with severe knee osteoarthritis are a result of reduced walking speed rather than disease severity.

Gait Posture 2020 May 16;79:256-261. Epub 2020 May 16.

Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, Switzerland; Department of Biomedical Engineering, University of Basel, Basel, Switzerland; Department of Spine Surgery, University Hospital Basel, Basel, Switzerland.

Background: Kinematic changes in patients with knee osteoarthritis (OA) have been extensively studied. Concerns have been raised whether the measured spatiotemporal and kinematic alterations are associated with disease progression or merely a result of reduced walking speed.

Research Question: The purpose of this study was to investigate the effect of walking speed on kinematic parameters in patients with knee OA using statistical parametric mapping (SPM). Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.008DOI Listing

Numerical estimations of the daily amount of skin-synthesized vitamin D by pre-school children in Poland.

J Photochem Photobiol B 2020 May 16;208:111898. Epub 2020 May 16.

Institute of Geophysics, Polish Academy of Sciences, Warsaw, Poland.

According to Polish guidelines, children need a daily dose of 600-1000 I·U. vitamin D, which could be skin-synthesized in the period May to September, after at least 15 min solar exposure between 10 am and 3 pm with uncovered forearms and lower legs. In Poland, doctors only prescribe oral supplementation to infants and small children up to 2 years old, rarely for the older children. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111898DOI Listing

Active thermography for real time monitoring of UV-B plant interactions.

J Photochem Photobiol B 2020 May 20;208:111900. Epub 2020 May 20.

Institute of Applied Sciences and Intelligent Systems "E. Caianiello" of CNR, 80072 Pozzuoli (Na), Italy.

Although Ultraviolet-B (UV-B)-plant interactions have been extensively analysed in the past years, many physiological aspects of the complex plant response mechanisms still need to be elucidated. Depending on the energy dose, this part of the electromagnetic spectrum can induce detrimental or beneficial effects in plant and fruit. In the present work, active thermography is used to analyse in real time the response of plants under different doses of artificial UV-B. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111900DOI Listing

Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII.

Eur J Med Chem 2020 May 6;200:112300. Epub 2020 May 6.

Università degli Studi di Firenze, NEUROFARBA Department, Section of Pharmaceutical Chemistry, Via Ugo Schiff 6, Sesto Fiorentino, Florence, 50019, Italy.

Oxathiino[6,5-b]pyridine 2,2-dioxides are identified as a new class of isoform-selective nanomolar inhibitors of tumor associated human carbonic anhydrases (hCA) IX and XII. At the same time they do not inhibit or poorly inhibit cytosolic isoforms hCA I and II. Oxathiino[6,5-b]pyridine 2,2-dioxides exhibited good antiproliferative properties on tumor cell lines MCF-7 (Human breast adenocarcinoma), A549 (human lung (alveolar) adenocarcinoma) and HeLa (epithelioid cervix carcinoma). Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112300DOI Listing

Activation of the Toll pathway in Aedes aegypti blocks the development of emerging third-stage larvae of drug-resistant Dirofilaria immitis.

Vet Parasitol 2020 May 5;282:109100. Epub 2020 May 5.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA. Electronic address:

Dirofilaria immitis is the globally distributed agent of heartworm disease. Infection in canines causes debilitating disease that can be fatal if left untreated. Macrocyclic lactones can prevent heartworm disease in dogs, cats and ferrets by killing larvae before they develop into adult worms in the pulmonary artery. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109100DOI Listing

The composition characteristics of different crop straw types and their multivariate analysis and comparison.

Waste Manag 2020 May 24;110:87-97. Epub 2020 May 24.

Engineering Laboratory for Agro-biomass Recycling & Valorizing, College of Engineering, China Agricultural University, Beijing 100083, China. Electronic address:

The heterogeneity and complex composition of crop straw are some of the main obstacles to its scientific and efficient industrial utilization. To thoroughly reveal and identify the composition of different crop straw types and their latent attributes, in this study, 784 straw samples of rice, wheat, corn, rape and cotton were collected. Based on the large sample size, 18 composition characteristics, including chemical composition, proximate composition, ultimate composition, and heating values, were adopted to determine the profiles of the crop straw composition characteristics. Read More

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http://dx.doi.org/10.1016/j.wasman.2020.05.018DOI Listing

Macronutrient and mineral intake effects on racing time and cardiovascular health in non-elite marathon runners.

Nutrition 2020 Mar 19;78:110806. Epub 2020 Mar 19.

Department of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernandez, Alicante Institute for Health and Biomedical Research (ISABIAL Foundation), Alicante, Spain; CIBERobn (Fisiopatología de la Obesidad y la Nutrición), Instituto de Salud Carlos III, Madrid, Spain.

Objective: The aim of this study was to analyze the intake of specific macronutrients and minerals that could influence cardiovascular health in recreational marathon runners.

Methods: We grouped 37 male runners into two groups according to their 50th percentile race time (3.39 h) and divided them into fast (group 1 [G1]: 3. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110806DOI Listing

Association between pyrethroid pesticide exposure and hearing loss in adolescents.

Environ Res 2020 May 8;187:109640. Epub 2020 May 8.

Department of Traditional Medicine, The People's Hospital of Cangnan, Wenzhou Medical University, No.2288 Yucang Road, Cangnan County, Zhejiang, 325800, China. Electronic address:

Background: Hearing loss in adolescents is a serious public health problem with a high prevalence. Pyrethroids are one of the most widely applied insecticides that have been linked to neurotoxicity. However, there is no study about the effect of pyrethroid insecticide exposure on the auditory system in the general population. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109640DOI Listing

Specific sources of health risks caused by size-resolved PM-bound metals in a typical coal-burning city of northern China during the winter haze event.

Sci Total Environ 2020 Apr 27;734:138651. Epub 2020 Apr 27.

Yale-NUIST Center on Atmospheric Environment, School of Applied Meteorology, International Joint Laboratory on Climate and Environment Change, Nanjing University of Information Science and Technology, Nanjing, 210044, China; Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science and Technology, Nanjing, 210044, China.

High particulate matter (PM) pollution frequently occurs in winter over northern China , resulting in threats to human health. To date, there are limited studies to link source apportionments and health risk assessments in the different size-resolved PM samples during high PM events. In this study, size-segregated PM samples were collected in Linfen, a typical coal-burning city, in northern China during a wintertime haze pollution. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138651DOI Listing

Genetically modified entomopathogenic bacteria, recent developments, benefits and impacts: A review.

Sci Total Environ 2020 May 11;734:139169. Epub 2020 May 11.

Department of Crop and Animal Production, Safiye Cikrikcioglu Vocational College, Kayseri University, Kayseri, Turkey.

Entomopathogenic bacteria (EPBs), insect pathogens that produce pest-specific toxins, are environmentally-friendly alternatives to chemical insecticides. However, the most important problem with EPBs application is their limited field stability. Moreover, environmental factors such as solar radiation, leaf temperature, and vapor pressure can affect the pathogenicity of these pathogens and their toxins. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139169DOI Listing

SARS-CoV-2 infection and air pollutants: Correlation or causation?

Sci Total Environ 2020 May 16;734:139489. Epub 2020 May 16.

University of Parma, Department of Medicine and Surgery, Via Gramsci n.14, 43123 Parma, PR, Italy.

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http://dx.doi.org/10.1016/j.scitotenv.2020.139489DOI Listing

Retraction notice to "Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells" [Stem Cell Res. 31 (2018) 62-70].

Stem Cell Res 2020 May 24;45:101830. Epub 2020 May 24.

Institute for Cardiogenetics, University of Luebeck, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Luebeck, Germany; University Heart Centre Luebeck, 23562 Luebeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2020.101830DOI Listing

PAHs in Chinese atmosphere Part II: Health risk assessment.

Ecotoxicol Environ Saf 2020 May 24;200:110774. Epub 2020 May 24.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China; IJRC-PTS, Dalian Maritime University, Dalian, 116026, China. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants in atmosphere, which attracted more attentions due to their influence on human health. In this study, a national scale cancer risk (CR) assessment with atmospheric PAHs were conducted based on one year monitoring program at 11 cities across China. The annual mean concentrations of benzo[a]pyrene (BaP) and BaP equivalency (BaP) were 4. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110774DOI Listing

A low-cost solvent-free method to synthesize α-FeO nanoparticles with applications to degrade methyl orange in photo-fenton system.

Ecotoxicol Environ Saf 2020 May 24;200:110744. Epub 2020 May 24.

School of Chemical Engineering of Sichuan University, Chengdu, 610065, PR China; Engineering Research Center of Comprehensive Utilization and Clean Processing of Phosphorus Resources, Ministry of Education, Chengdu, 610065, PR China.

Hematite nanoparticles (α-FeO NPs) were successfully synthesized by a low-cost solvent-free reaction using Ferrous sulfate waste (FeSO·7HO) and pyrite (FeS) as raw materials and employed for the decolorization of Methyl Orange by the photo-Fenton system. The properties of α-FeO NPs before and after photo-Fenton reaction were characterized by X-ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), Fourier transform infrared (FT-IR) spectrum and X-ray photoelectron spectroscopy (XPS), and the optical properties of α-FeO NPs were analyzed by UV-vis diffuse reflectance spectra (UV-vis DRS) and Photoluminescence (PL) spectra. The analytic results showed that the as-formed samples having an average diameter of ~50 nm exhibit pure phase hematite with sphere structure. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110744DOI Listing

Effect of interspecific competition on species sensitivity distribution models: Analysis of plant responses to chemical stress.

Ecotoxicol Environ Saf 2020 May 24;200:110722. Epub 2020 May 24.

Université de Lorraine, CNRS, LIEC, F-57000 Metz, France.

Species Sensitivity Distributions (SSD) are widely used in environmental risk assessment to predict the concentration of a contaminant that is hazardous for 5% of species (HC). They are based on monospecific bioassays conducted in the laboratory and thus do not directly take into account ecological interactions. This point, among others, is accounted for in environmental risk assessment through an assessment factor (AF) that is applied to compensate for the lack of environmental representativity. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110722DOI Listing

Driver performance under simulated and actual driving conditions: Validity and orthogonality.

Accid Anal Prev 2020 May 24;143:105593. Epub 2020 May 24.

School of Applied Psychology, University College Cork, Cork, Ireland.

This study contrasted the performance of drivers under actual and simulated driving conditions, in order to assess the validity of the simulators and test the hypothesis that driving is composed of largely orthogonal sub-tasks. Thirty experienced drivers completed an on-road driving test and drove two different simulators, each simulator drive comprising seven difficulty-moderated driving scenarios. Between-simulator contrasts revealed largely absolute validity, the anticipated effects of increased difficulty within driving scenarios, but weak relationships between performance of different driving scenarios. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105593DOI Listing

Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array.

Cell Rep 2020 May;31(8):107670

LadHyX and Department of Mechanics, Ecole Polytechnique, CNRS, 91128 Palaiseau, France; Physical Microfluidics and Bio-Engineering, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France. Electronic address:

As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids within anchored droplets. Different conditions can be applied in a single device by triggering the merging of new droplets with the spheroid-containing drops. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107670DOI Listing

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.

Cell Stem Cell 2020 May 20. Epub 2020 May 20.

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 Leiden, the Netherlands; Department of Applied Stem Cell Technologies, University of Twente, 7500 Enschede, the Netherlands. Electronic address:

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered tissues or forced contraction. Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs). hiPSC-CMs in MTs with CFs showed improved sarcomeric structures with T-tubules, enhanced contractility, and mitochondrial respiration and were electrophysiologically more mature than MTs without CFs. Read More

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http://dx.doi.org/10.1016/j.stem.2020.05.004DOI Listing

Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina.

Trends Neurosci 2020 Jun 17;43(6):433-449. Epub 2020 Apr 17.

Department of Ophthalmology, Duke University, Durham, NC 27710, USA; Department of Immunology, Duke University,Durham, NC 27710, USA. Electronic address:

Unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not solely comprised of microglia but may include monocyte-derived recruits. Recent studies have applied transgenics, lineage-tracing, and transcriptomics to help decipher the distinct roles of these two cell types in the diseasesettings of inherited retinal degenerations and age-related macular degeneration.Literature discussed here focuses on the ectopic presence of both macrophage types in the extracellular site surrounding the outer aspect ofphotoreceptor cells (i. Read More

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http://dx.doi.org/10.1016/j.tins.2020.03.012DOI Listing

[Verification of dengue fever cases imported to the territory of the south Far East.]

Authors:
G N Leonova

Klin Lab Diagn 2020 ;65(6):382-386

Somov Institute of Epidemiology and Microbiology, 690087, Vladivostok, Russia.

There are various diagnostic and research methods for detecting cases of Dengue fever, the effectiveness of which is given in this work.

Materials And Methods: On biomaterial from 70 people, verification of imported cases of Dengue fever into the south of the Far East from 2012 to 2019 is shown. Serological and virological methods were used, as well as PCR. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-6-382-386DOI Listing
January 2020

Pertussis vaccination and Allergic illness in Australian children.

Pediatr Allergy Immunol 2020 May 27. Epub 2020 May 27.

Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.

There has been ongoing interest in the temporal association between the change from whole cell pertussis (wP)-containing to acellular pertussis (aP)-containing vaccines in the routine infant immunization schedule in Australia and increases in childhood food allergies. This is because of the tendency of aP, but not wP, vaccines to promote TH2 immune responses, which are known to predispose children to allergy and allergic disease A recent analysis of ICD coded data for anaphylaxis-related hospitalisations in Australia found that observed increases between the years 1998-1999 and 2004-2005 continued between the years 2005-2006 and 2011-20012, especially in older children. Read More

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http://dx.doi.org/10.1111/pai.13300DOI Listing

Comparative physiological and proteomic analysis deciphering tolerance and homeostatic signaling pathways in Chrysanthemum under drought stress.

Physiol Plant 2020 May 27. Epub 2020 May 27.

Horticulture and Molecular Physiology Lab, School of Agricultural Innovations and Advanced Learning, Vellore Institute of Technology, Vellore, -632014, Tamil-Nadu, India.

Drought is increasing prevalently, mostly due to global warming, and harmful effects associated with drought stress include a reduction in the developmental phases of the plant life cycle. Drought stress affects vital metabolic processes in plants such as transpiration, photosynthesis, and respiration. The other physiological and cellular processes like protein denaturation and aggregation are also affected by drought. Read More

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http://dx.doi.org/10.1111/ppl.13142DOI Listing
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