1,060,668 results match your criteria Applied physiology nutrition and metabolism = Physiologie appliquee nutrition et metabolisme[Journal]


Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis and grading of pancreatic neuroendocrine tumors: a retrospective analysis of 110 cases.

Endoscopy 2020 Jun 4. Epub 2020 Jun 4.

General and Pancreatic Surgery Unit, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.

Background:  Data on the reliability of the Ki-67 index and grading calculations from endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic neuroendocrine tumors (PanNETs) are controversial. We aimed to assess the accuracy of these data compared with histology.

Methods:  Cytological analysis from EUS-FNA in patients with suspected PanNETs (n = 110) were compared with resection samples at a single institution. Read More

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http://dx.doi.org/10.1055/a-1180-8614DOI Listing

What the COVID-19 Crisis Is Telling Humanity.

Neuroepidemiology 2020 Jun 4:1-4. Epub 2020 Jun 4.

National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand.

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http://dx.doi.org/10.1159/000508654DOI Listing

Voltage- and temperature-dependent rare-earth dopant contribution to the interfacial magnetic anisotropy.

J Phys Condens Matter 2020 Jun 4. Epub 2020 Jun 4.

Institute for Materials Research & WPI-AIMER & CSRN, Tohoku University, Sendai, Miyagi, JAPAN.

The control of magnetic materials and devices by voltages without electric currents holds the promise of power-saving nano-scale devices. Here we study the temperature-dependent voltage control of the magnetic anisotropy caused by rare-earth (RE) local moments at an interface between a magnetic metal and a non-magnetic insulator, such as Co|(RE)|MgO. Based on a Stevens operator representation of crystal and applied field effects, we find large dominantly quadrupolar intrinsic and field-induced interface anisotropies at room temperature. Read More

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http://dx.doi.org/10.1088/1361-648X/ab997cDOI Listing

Triboelectric nanogenerators based on graphene oxide coated nanocomposite fibers for biomedical applications.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Department of Electerical Engineering, Isfahan University of Technology, Isfahan, IRAN, ISLAMIC REPUBLIC OF.

High demand for green and eco-friendly triboelectric nanogenerators (TENGs) have multiplied the importance of their degradability for biomedical applications. However, the charge generation of the current eco-friendly TENGs is generally limited. In this research, a flexible TENG based on Silk fibroin (SF) fibrous layer and polycaprolactone (PCL)/graphene oxide (GO) fibrous layer was developed. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9972DOI Listing

Low-temperature synthesis and electrocatalytic application of large-area PtTe2 thin films.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

AMBER and School of Chemistry, University of Dublin Trinity College, Dublin, 2, IRELAND.

The synthesis of transition metal dichalcogenides (TMDs) has been a primary focus for 2D nanomaterial research over the last 10 years, however, only a small fraction of this research has been concentrated on transition metal ditellurides. In particular, nanoscale platinum ditelluride (PtTe2) has rarely been investigated, despite its potential applications in catalysis, photonics and spintronics. Of the reports published, the majority examine mechanically-exfoliated flakes from chemical vapor transport (CVT) grown crystals. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9973DOI Listing

Nanocomposite of Ag NPs and Catalytic Fluorescent Cdots for Synergistic Bactericidal Activity through Enhanced ROS Generation.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Applied Sciences, IIIT Allahabad, Allahabad, 211012, INDIA.

Synthesis of catalytic fluorescent carbon dots (Cdots) by using microwave irradiation is proposed considering biodegradable starch as precursor. The as-synthesized Cdots was characterized by using fluorescence spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) analysis. It was showing high catalytic activity in photo-reduction method for formation of Silver nanoparticles (Ag NPs) without adding any additional surface passivating agents. Read More

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http://dx.doi.org/10.1088/1361-6528/ab996fDOI Listing

Highly sensitive wearable flexible strain sensor based on poly-crystalline MoS2 thin film.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Centre for Applied Research in Electronics (CARE), Indian Institute of Technology Delhi, New Delhi, 110016, INDIA.

The present study investigates the piezoresistive property of poly-crystalline MoS2 film for strain sensing applications. The gauge factor (GF) of flexible MoS2 device (MoS2/PET) has been calculated to be 102±5 in the stress ranging from ~7 MPa to ~14 MPa. In addition, to improve the sensing stress range, the flexible strain sensors are encapsulated by SU-8. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9970DOI Listing

Giant Magnetocaloric Effect in Nanostructured Fe-Co-P Amorphous Alloys Enabled through Pulse Electrodeposition.

Nanotechnology 2020 Jun 4. Epub 2020 Jun 4.

Department of Mechanical Engineering, Hong Kong Polytechnic University, Hung Hom, Kowloon, HONG KONG.

In this work, amorphous Fe-Co-P films prepared by electrodeposition are found to exhibit dense microstructures with amorphous grains. Through a pulse electrodeposition synthesis route, complex microstructures containing nano-sized grains are obtained in the amorphous alloy films. The nanostructured Fe-Co-P amorphous alloys show superior soft magnetic and magnetocaloric properties as compared with those of other iron-based soft magnetic amorphous alloys reported to date. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9971DOI Listing

NAD(P)-dependent glucose dehydrogenase: Applications for biosensors, bioelectrodes, and biofuel cells.

Bioelectrochemistry 2020 May 23;135:107574. Epub 2020 May 23.

Faculty of Chemistry, University of Warsaw, Pasteura St. 1, 02-093 Warsaw, Poland. Electronic address:

This review discusses the physical and chemical properties of nicotinamide redox cofactor dependent glucose dehydrogenase (NAD(P) dependent GDH) and its extensive application in biosensors and bio-fuel cells. GDHs from different organisms show diverse biochemical properties (e.g. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2020.107574DOI Listing

Auto In Silico Ligand Directing Evolution to Facilitate the Rapid and Efficient Discovery of Drug Lead.

iScience 2020 May 18;23(6):101179. Epub 2020 May 18.

Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China; International Joint Research Center for Intelligent Biosensor Technology and Health, Central China Normal University, Wuhan 430079, China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, P. R. China. Electronic address:

Motivated by the growing demand for reducing the chemical optimization burden of H2L, we developed auto in silico ligand directing evolution (AILDE, http://chemyang.ccnu.edu. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101179DOI Listing

Discrimination of automotive window tint using ATR-FTIR spectroscopy and chemometrics.

Forensic Sci Int 2020 May 16;313:110338. Epub 2020 May 16.

School of Molecular and Life Sciences, Curtin University, GPO Box U1987, Perth, WA 6845, Australia; Curtin Institute of Functional Molecules and Interfaces, Curtin University, GPO Box U1987, Perth, WA 6845, Australia. Electronic address:

Automotive window tints are commonly applied to motor vehicles to reduce transmittance of light and heat into the interior. They may hence be encountered as physical evidence in criminal investigations, or in civil matters where a tint is suspected to originate from a different source than advertised. Establishing a tint's provenance would be highly relevant in such cases. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110338DOI Listing

Classifying individuals with and without patellofemoral pain syndrome using ground force profiles - Development of a method using functional data boosting.

Gait Posture 2020 May 25;80:90-95. Epub 2020 May 25.

Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston B152TT, United Kingdom; LUNEX International University of Health, Exercise and Sports, 50, avenue du Parc des Sports, L-4671 Differdange, Luxembourg.

Background: Predictors of recovery in patellofemoral pain syndrome (PFPS) currently used in prognostic models are scalar in nature, despite many physiological measures originally lying on the functional scale. Traditional modelling techniques cannot harness the potential predictive value of functional physiological variables.

Research Question: What is the classification performance of PFPS status of a statistical model when using functional ground reaction force (GRF) time-series?

Methods: Thirty-one individuals (control = 17, PFPS = 14) performed maximal countermovement jumps, on two force plates. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.034DOI Listing

Systemic therapy in metastatic renal cell carcinoma: Emerging challenges in therapeutic choice.

Crit Rev Oncol Hematol 2020 Jun 1;152:102971. Epub 2020 Jun 1.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada; Canadian Centre for Applied Research in Cancer Control, Toronto, Ontario, Canada. Electronic address:

The treatment landscape for metastatic renal cell carcinoma (mRCC) has undergone a substantial evolution in the past decade, with a dramatic increase in the number of available systemic therapies. Although this offers promise for improved patient outcomes, this rapid pace in development has led to new challenges in therapeutic choice. For instance, the absence of direct comparative evidence across all therapeutic options has led to a critical gap in evidence to clearly define preferred systemic therapy choice. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102971DOI Listing

Cultivation dependent formation of siderophores by Gordonia rubripertincta CWB2.

Microbiol Res 2020 May 26;238:126481. Epub 2020 May 26.

Institute of Biosciences, Environmental Microbiology Group, TU Bergakademie Freiberg, Leipziger Straße 29, 09599 Freiberg, Germany; Microbial Biotechnology, Faculty of Biology and Biotechnology, Ruhr-Universität Bochum, Universitätsstraße 150, 44780 Bochum, Germany. Electronic address:

Herein we demonstrate cultivation-dependent siderophore production by the actinomycete Gordonia rubripertincta CWB2. The strain produces mostly citrate, but also desferrioxamine E (DFOE) and new hydroxamate-type siderophores. The production of hydroxamate-like siderophores is influenced by cultivation conditions, for example available carbon sources or presence of metals, such as the rare earth erbium or the heavy metal lead. Read More

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http://dx.doi.org/10.1016/j.micres.2020.126481DOI Listing

Cross-interface transfer of polycyclic aromatic hydrocarbons (PAHs) in a shallow urban lake in Shanghai, China based on the fugacity model.

Sci Total Environ 2020 May 12;736:139369. Epub 2020 May 12.

Key Laboratory of Geographic Information Science (Ministry of Education), East China Normal University, 200241 Shanghai, China; School of Geographical Sciences, East China Normal University, 200241 Shanghai, China.

Shallow urban lakes are important urban ecosystems; however, these systems are subject to severe polycyclic aromatic hydrocarbons (PAHs) contamination. An understanding of the distribution and dynamics of PAHs in lakes is required to restore the functions of lake ecosystems and to ensure the ecological security of urban water sources. The Quantitative Water Air Sediment Interaction (QWASI) model and partition coefficient and fugacity fraction methods were applied to estimate the multimedia transfers of PAHs in Dianshan Lake, a typical shallow lake in Shanghai, China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139369DOI Listing

Dextran stabilized fullerene soot induced toxicity on alveolar epithelial cells (A549 cells).

Environ Res 2020 May 26;188:109716. Epub 2020 May 26.

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum, 695 012, Kerala, India. Electronic address:

Fullerene comprises the major allotrope of carbon holding several fruitful potentials to be applied in various industrial and biomedical scenarios. Scientists have acquired large number of data on fullerene research using its derivatives like C60, C70 etc. Nevertheless, a precise focus on fullerene soot nanopaticles and its toxic impacts in living tissue is still behind mainstay even if it represents the crude parent form of all other derivatives. Read More

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http://dx.doi.org/10.1016/j.envres.2020.109716DOI Listing

Low-current electro-oxidation enhanced the biodegradation of the recalcitrant naphthenic acids in oil sands process water.

J Hazard Mater 2020 May 19;398:122807. Epub 2020 May 19.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB, T6G 2W2, Canada. Electronic address:

Combining electro-oxidation (EO) with biodegradation for real oil sands process water (OSPW) treatment was evaluated in terms of naphthenic acid (NA) biodegradation enhancement. Ion mobility spectrometry (IMS) qualitative analysis showed that EO by graphite was able to degrade the different NA clusters in OSPW including: classical, oxidized and heteroatomic NAs. Applying EO even at current density as low as 0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122807DOI Listing

Removal and recovery of heavy metals from soil with sodium alginate coated FeSSi nanocomposites in a leaching process.

J Hazard Mater 2020 May 16;398:122732. Epub 2020 May 16.

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China. Electronic address:

Leaching technology has been widely applied to remove heavy metals (HMs) from soil, although the synchronous recovery of multiple HMs during the leaching process was rarely studied. In this study, we synthesized silicon sulfuretted nanoscale zero-valent iron (FeSSi), which was coated with sodium alginate (SA) to form the gel beads (SA-FeSSi). The specific surface area of FeSSi (101. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122732DOI Listing

Simultaneous determination of neonicotinoids and fipronils in tea using a modified QuEChERS method and liquid chromatography-high resolution mass spectrometry.

Food Chem 2020 May 29;329:127159. Epub 2020 May 29.

NHC Key Laboratory of Food Safety Risk Assessment; Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China. Electronic address:

The widespread use of neonicotinoids (NEOs) and fipronils (FIPs) as insecticides in modern agriculture has been widely investigated because of their adverse effects on human health. This study aimed to develop an accurate quantitative approach to analyze NEOs and FIPs in tea by using a modified QuEChERS method based on dispersive solid-phase extraction procedure coupled with liquid chromatography-high resolution mass spectrometry. To minimize matrix interferences largely, we selected polyvinylpolypyrrolidone (PVPP) and strong cationic exchange adsorbent (PCX) as dispersive adsorbents to eliminate polyphenols and caffeine from tea extract, respectively. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127159DOI Listing

First dataset of U and U around the Greenland coast: A 5-year snapshot (2012-2016).

Chemosphere 2020 May 26;257:127185. Epub 2020 May 26.

VERA Laboratory, Faculty of Physics - Isotope Physics, University of Vienna, Währinger Straße 17, A-1090 Vienna, Austria.

We report the first combined dataset of U and U in the Greenland marine environment during the period of 2012-2016. Results are discussed in terms of time evolution and spatial distribution of U concentration, and atomic ratios of U/U and U/U. U concentrations along the Greenland coast are distributed within a relatively narrow range of (0. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127185DOI Listing

Multiannual monitoring (1974-2019) of rare earth elements in wild growing edible mushroom species in Polish forests.

Chemosphere 2020 May 28;257:127173. Epub 2020 May 28.

Poznań University of Life Sciences, Department of Chemistry, Wojska Polskiego 75, 60-625, Poznań, Poland. Electronic address:

There is a growing demand for rare earth elements (REEs) due to their use in modern technologies, and this may result in their emission to the environment. This is the first long-term study to monitor the content of REEs in four edible mushroom species. Over 21,900 samples of fruit bodies (sporocarps) of Boletus edulis, Imleria badia, Leccinum scabrum and Macrolepiota procera and their underlying soils, collected between 1974 and 2019 from 42 forest sites in Poland were examined in an attempt to understand the time evolution of the presence of REEs in the environment. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127173DOI Listing

Synergistic effect of 222-nm krypton-chlorine excilamp and mild heating combined treatment on inactivation of Escherichia coli O157:H7 and Salmonella Typhimurium in apple juice.

Int J Food Microbiol 2020 May 19;329:108665. Epub 2020 May 19.

Department of Food and Animal Biotechnology, Department of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute for Agricultural and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea; Institutes of Green Bio Science & Technology, Seoul National University, Pyeongchang-gun, Gangwon-do 25354, Republic of Korea. Electronic address:

Simultaneous treatment with 222-nm KrCl excilamp and mild heating (EX-MH) at 45, 50 and 55 °C showed synergistic bactericidal effects on non-acid and acid adapted cells of Escherichia coli O157:H7 and Salmonella Typhimurium in apple juice. In particular, acid-adapted pathogens exhibited increased resistance to EX-MH compared to pathogenic bacteria that were not acid-adapted. Also, elucidation of the synergistic bactericidal mechanism of EX-MH was performed through several assays and this mechanism was described as follows: (i) when KrCl excilamp (EX) and mild heating (MH) are applied simultaneously, MH reversibly inactivates the antioxidant enzyme, superoxide dismutase (SOD), thereby increasing accumulation of reactive oxygen species (ROS) generated by EX and thus inducing synergistic ROS generation, (ii) ROS production induces lipid peroxidation occurrence in the cell membrane, (iii) this lipid peroxidation occurrence in the cell membrane induces synergistic destruction of cell membrane, resulting in synergistic cell death. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108665DOI Listing

An experimental and algorithm-based study of the spectral features of breast cancer patients by a photodiagnosis approach.

Photodiagnosis Photodyn Ther 2020 Jun 1:101851. Epub 2020 Jun 1.

Department of Electrical Computer Engineering, COMSATS University Islambad, Islamabad Campus, Park Road, Chak Shahzad, Islamabad, 45550, Pakistan.

In the present study, the spectral diagnosis of blood plasma samples of breast cancer patients and an equal number of normal controls was investigated. A set of ratio parameters was acquired by employing SXS and FES. The samples were also analyzed statistically by employing Welch two-sample t-tests, and the effects of three ratio parameters, R, R, and R, were also studied by plotting them against the subject numbers. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101851DOI Listing

Functional PVDF ultrafiltration membrane for Tetrabromobisphenol-A (TBBPA) removal with high water recovery.

Water Res 2020 May 18;181:115952. Epub 2020 May 18.

Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada; Institute for Energy, Environment and Sustainable Communities, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.

Tetrabromobisphenol-A (TBBPA) is one of the most important brominated flame retardants (BFRs), accounting for 60% of the total commercial BFR market. Increasing amounts of TBBPA and byproducts are released to the aquatic environment due to their extensive utilization in various sectors. However, research on the treatment of TBBPA contaminated wastewater using membrane filtration is still lacked. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115952DOI Listing

Interactions of antithrombotic herbal medicines with Western cardiovascular drugs.

Pharmacol Res 2020 Jun 1:104963. Epub 2020 Jun 1.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, 999078, China. Electronic address:

Thrombotic events act as a critical factor that interferes with Cardiovascular Diseases (CVDs), and antithrombotic herbal medicine is a long-standing controversial issue. Although a dispute is involved in their clinical application, all parties unanimously agree that herbal products have been widely used in folk medicine, and their interactions with conventional drugs are of high concern. This study aims to investigate how antithrombotic herbal medicines interact with Western cardiovascular drugs on the molecular level by taking an example of the most frequently used herbal pair, Danshen-Chuanxiong (DS-CX), and to discover more scientific evidence on their potential herbal-drug interactions. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104963DOI Listing

Electric Field Induced Release and Measurement (EFIRM): Characterization and Technical Validation of a Novel Liquid Biopsy Platform in Plasma and Saliva.

J Mol Diagn 2020 Jun 1. Epub 2020 Jun 1.

UCLA From the School of Dentistry; Liquid Diagnostics LLC, San Clemente, California. Electronic address:

Electric Field Induced Release and Measurement (EFIRM) is a novel, plate based, liquid biopsy platform capable of detecting circulating tumor DNA containing EGFR mutations directly from saliva and plasma in both early and late stage patients with non-small cell lung cancer (NSCLC). We investigated the properties of the target molecule for EFIRM and determined that the platform preferentially detects single stranded DNA molecules. We then investigated the properties of the EFIRM assay and determined the linearity, linear range, precision, and limit of detection, for 6 different EGFR variants (the 4 most common g. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2020.05.005DOI Listing

The effect of acupressure on the severity of pruritus and laboratory parameters in patients undergoing hemodialysis: A randomized clinical trail.

J Acupunct Meridian Stud 2020 Jun 1. Epub 2020 Jun 1.

Nephrology-urology research center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Objectives: The aim of this study is to determine the effect of acupressure on the severity of pruritus and some laboratory parameters in patients undergoing hemodialysis.

Materials And Methods: The present clinical trial was conducted on 90 hemodialysis patients. Pressure was applied on SP6, SP10, ST36, and LI11 points in the intervention group and on ineffective points for the sham control group. Read More

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http://dx.doi.org/10.1016/j.jams.2020.05.002DOI Listing

Nanoparticles for topical drug delivery: Potential for skin cancer.

Adv Drug Deliv Rev 2020 Jun 1. Epub 2020 Jun 1.

John A. Paulson School of Engineering & Applied Sciences Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, United States of America. Electronic address:

Nanoparticles offer new opportunities for the treatment of skin diseases. The barrier function of the skin poses a significant challenge for nanoparticles to permeate into the tissue, although the barrier is partially compromised in case of injury or inflammation, as in the case of skin cancer. This may facilitate penetration of nanoparticles. Read More

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http://dx.doi.org/10.1016/j.addr.2020.05.011DOI Listing

Efficient degradation of bisphenol A in water by heterogeneous activation of peroxymonosulfate using highly active cobalt ferrite nanoparticles.

J Hazard Mater 2020 May 20;399:122979. Epub 2020 May 20.

Environmental Engineering and Science Program, University of Cincinnati, OH, 45221-0071, United States. Electronic address:

Cobalt ferrite CoFeO catalyst was fabricated and systematically investigated as an efficient peroxymonosulfate (PMS, HSO) activator for the degradation of recalcitrant organic contaminants (ROCs) in water treatment. Both SO and OH on the surface of catalyst were unveiled to be primarily responsible for bisphenol A (BPA) degradation by a comprehensive study using electron paramagnetic resonance (EPR), radical scavengers and quantification of SO, and the negligible contribution of singlet oxygen (O) was also observed. BPA degradation was accelerated in the presence of humic acid, and it increased first but then decreased with the further addition of fulvic acid. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.122979DOI Listing

Comparison of passive-dosed and solvent spiked exposures of pro-carcinogen, benzo[a]pyrene, to human lymphoblastoid cell line, MCL-5.

Toxicol In Vitro 2020 Jun 1:104905. Epub 2020 Jun 1.

In Vitro Toxicology Group, Institute of Life Science 1, Swansea University Medical School, Singleton Campus, Swansea SA2 8PP, UK.

Genotoxicity testing methods in vitro provide a means to predict the DNA damaging effects of chemicals on human cells. This is hindered in the case of hydrophobic test compounds, however, which will partition to in vitro components such as plastic-ware and medium proteins, in preference to the aqueous phase of the exposure medium. This affects the freely available test chemical concentration, and as this freely dissolved aqueous concentration is that bioavailable to cells, it is important to define and maintain this exposure. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104905DOI Listing

Cardiac Irradiation Predicts Activity Decline in Patients Receiving Concurrent Chemoradiation for Locally Advanced Lung Cancer.

Int J Radiat Oncol Biol Phys 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiation Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York. Electronic address:

Purpose: Many lung cancer patients are inactive due to their disease and underlying comorbidities, and activity levels can decline further during cancer therapy. Here we explore dosimetric predictors of activity decline in a cohort of patients who underwent continuous activity monitoring during definitive concurrent chemoradiotherapy (CRT) for locally advanced lung cancer.

Methods And Materials: We identified patients who participated in prospective clinical trials involving the use of a commercial fitness tracker throughout the course of CRT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.042DOI Listing

Development of laboratory-scale sequential electrokinetic and biological treatment of chronically hydrocarbon-impacted soils.

N Biotechnol 2020 Jun 1. Epub 2020 Jun 1.

Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia, Via S. Camillo De Lellis, 00110, Viterbo, Italy.

This study focused on the remediation of a chronically diesel-polluted soil by combining an electrokinetic treatment with a variety of bioremediation approaches. Priority within the sequential treatment was given to electrokinetic remediation (EKR) since the application of natural attenuation (NA), biostimulation and site-specific bio-augmentation resulted in very low degradation performance for total petroleum hydrocarbons (TPH) and polycyclic hydrocarbons (PAH). The application of 20-day EKR (1. Read More

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http://dx.doi.org/10.1016/j.nbt.2020.04.002DOI Listing

An automated method for removal of striping artifacts in fluorescent whole-slide microscopy.

J Neurosci Methods 2020 Jun 1:108781. Epub 2020 Jun 1.

Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11794-3800, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA. Electronic address:

Background: Whole slide scanners often acquire images of tissue sections that are larger than their field of view through tile or line-scanning. The subsequently stitched or aligned images can often suffer from imaging artifacts such as horizontal or vertical stripes. These stripes degrade the image quality in fluorescent biological imaging samples and can also limit the accuracy of any subsequent analyses such as cell segmentation. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2020.108781DOI Listing

Surface modification and bioconjugation of anti-CD4 monoclonal antibody to magnetic nanoparticles as a highly efficient affinity adsorbent for positive selection of peripheral blood T CD4+ lymphocytes.

Int J Biol Macromol 2020 Jun 1. Epub 2020 Jun 1.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran; Immunology Research Center (IRC), Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Magnetic activated cell sorting (MACS) is a straightforward and time-saving procedure for isolation of different healthy functional cells. The present study aimed for the developing of a new MACS-based platform for isolation of peripheral blood T CD4+ lymphocytes. For this goal, first: FeO magnetic nanoparticles (MNP) were prepared by co-precipitation of Fe (III) and Fe (II) ions and then coated by SiO shell, followed by the grafting of N-(phosphonomethyl) iminodiacetic acid (PMIDA) on the surface of fabricated MNP, FeO@SiO@PMIDA were formed. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.264DOI Listing

Modified PRISM and SCI-SET Spasticity Measures for Persons with Traumatic Spinal Cord Injury: Results of a Rasch Analyses.

Arch Phys Med Rehabil 2020 Jun 1. Epub 2020 Jun 1.

Crawford Research Institute, Shepherd Center, Atlanta, GA; Department of Rehabilitation Medicine, School of Medicine, Emory University, Atlanta, GA; Program in Applied Physiology, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA.

Objective: Evaluate the psychometric properties of the SCI-SET and PRISM using Rasch analysis to optimize their validity and efficiency.

Design: Rasch analysis of the SCI-SET and PRISM represents a secondary analysis of data collected as part of a collaborative research project of the SCI Model Systems Centers. The overall survey was organized into four sections: 1) participant demographics and injury characteristics, 2) participant experiences of spasticity, 3) SCI-SET, and 4) PRISM. Read More

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http://dx.doi.org/10.1016/j.apmr.2020.05.012DOI Listing

Investigation of Two Different Pressure-Based Controlled Ice Nucleation Techniques in Freeze-Drying: The Integral Role of Shelf Temperature After Nucleation in Process Performance and Product Quality.

J Pharm Sci 2020 Jun 1. Epub 2020 Jun 1.

Friedrich-Alexander University (FAU) Erlangen-Nuernberg, Department of Pharmaceutics, Freeze Drying Focus Group (FDFG), Cauerstrasse 4, 91058 Erlangen, Germany; GILYOS GmbH, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany. Electronic address:

The purpose of this study was to investigate the impact of shelf temperature modifications during application of controlled ice nucleation techniques on process data and critical product quality attributes for a challenging, high-concentration and high-fill volume amorphous model system. Different freezing programs were applied and compared for the mechanistically different depressurization and vacuum-induced surface freezing techniques. Critical process data, such as product temperature and drying time, were analyzed. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.05.020DOI Listing

Suitability of the z-Factor for Dissolution Simulation of Solid Oral Dosage Forms: Potential Pitfalls and Refinements.

J Pharm Sci 2020 Jun 1. Epub 2020 Jun 1.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany.

Parameterization of dissolution profiles for subsequent use in in silico modeling and simulation is a crucial element for the success of extrapolating in vitro to in vivo release from solid oral dosage forms. The z-factor dissolution model is an option that can be utilized in commercial software such as GastroPlus to simulate the release from solid oral dosage forms. However, several aspects that can confound particle dissolution, such as disintegration and coning, are currently not taken into consideration in this model. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.05.019DOI Listing

A systematic review of interventions after restoring the occluding surfaces of anterior and posterior teeth that are affected by tooth wear with filled resin composites.

J Dent 2020 Jun 1:103388. Epub 2020 Jun 1.

Prosthodontics, Centre for Oral, Clinical and Translational Sciences, Guy's Hospital, London, UK.

Objectives: The aim of this systematic review was to assess intervention rates of direct composite restorations in the worn dentition based on data published in clinical trials.

Methods: Searches of electronic data bases, grey Literature and hand searches were completed, and selection criteria were applied at the title, abstract and full paper stages. Unavailable full papers or papers with unsuitable data were excluded. Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103388DOI Listing

A randomised controlled trial investigating efficacy of a novel toothpaste containing calcium silicate and sodium phosphate in dentine hypersensitivity pain reduction compared to a fluoride control toothpaste.

J Dent 2020 Apr 1:103320. Epub 2020 Apr 1.

Clinical Trials Group, Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK. Electronic address:

Objectives: To compare a calcium silicate and sodium phosphate toothpaste (CSSP) with a fluoride negative control toothpaste for dentine hypersensitivity (DH) pain reduction after 14, 28 and 29 days.

Methods: This was a double blind, parallel study in 247 healthy adults with DH (Schiff score >2, tactile 10-20 g) in 2 teeth in different quadrants of the mouth. After acclimatisation, participants were randomised to CSSP or control toothpaste. Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103320DOI Listing

Oligomerization analysis as a tool to elucidate the mechanism of EBV latent membrane protein 1 inhibition by pentamidine.

Biochim Biophys Acta Biomembr 2020 Jun 1:183380. Epub 2020 Jun 1.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation. Electronic address:

Latent membrane protein 1 (LMP1) is a gene product of the Epstein-Barr virus (EBV), a widely spread virus present in 90-95% of the world's population. EBV can lead to several malignancies, in which LMP1 was shown to play a key role. LMP1 is active only in the oligomeric form and its fifth transmembrane domain (TMD-5) is critical for the oligomerization, with D150 identified as a key residue for LMP1 activation. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183380DOI Listing

New records and DNA barcoding of deer flies, Chrysops (Diptera: Tabanidae) in Thailand.

Acta Trop 2020 Jun 1:105532. Epub 2020 Jun 1.

Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, 10900, Thailand.

Chrysops spp. or deer flies (Diptera: Tabanidae) are hematophagous flies of medical and veterinary importance and some species are important vectors of Trypanosoma evansi, the causative agent of surra in Thailand. However, data regarding deer fly species and their molecular identification are limited. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105532DOI Listing

Emotion recognition with convolutional neural network and EEG-based EFDMs.

Neuropsychologia 2020 Jun 1:107506. Epub 2020 Jun 1.

Intelligent Systems Research Centre, Ulster University, Londonderry, United Kingdom.

Electroencephalogram (EEG), as a direct response to brain activity, can be used to detect mental states and physical conditions. Among various EEG-based emotion recognition studies, due to the non-linear, non-stationary and the individual difference of EEG signals, traditional recognition methods still have the disadvantages of complicated feature extraction and low recognition rates. Thus, this paper first proposes a novel concept of electrode-frequency distribution maps (EFDMs) with short-time Fourier transform (STFT). Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2020.107506DOI Listing

A Mechanistic Model of the Regulation of Division Timing by the Circadian Clock in Cyanobacteria.

Biophys J 2020 May 20. Epub 2020 May 20.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts. Electronic address:

The cyanobacterium Synechococcus elongatus possesses a circadian clock in the form of a group of proteins whose concentrations and phosphorylation states oscillate with daily periodicity under constant conditions. The circadian clock regulates the cell cycle such that the timing of the cell divisions is biased toward certain times during the circadian period, but the mechanism underlying this phenomenon remains unclear. Here, we propose a mechanism in which a protein limiting for division accumulates at a rate proportional to the cell volume growth and is modulated by the clock. Read More

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http://dx.doi.org/10.1016/j.bpj.2020.04.038DOI Listing

Effectiveness of Aquatain AMF and Cocobear™ Larvicidal Oil Against Larvae and Pupae in an Organically Enhanced Aquatic Habitat.

J Am Mosq Control Assoc 2020 Mar;36(1):47-50

The efficacy of CocoBear™ Larvicidal Oil and Aquatain AMF Liquid Mosquito Film against larval and pupal was compared (at maximum label field application rates) when applied to concrete troughs treated with composted cow manure. At 1 h posttreatment, CocoBear provided significantly greater reduction of mosquito larvae than Aquatain, but both products were equally effective in producing >97% control at 24 h. Each product provided >98% pupal reduction at 1 h posttreatment, with complete elimination of pupae from troughs at 24 h. Read More

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http://dx.doi.org/10.2987/19-6862.1DOI Listing

Transfluthrin Spatial Repellent on US Military Materials Reduces Incursion in a Desert Environment.

J Am Mosq Control Assoc 2020 Mar;36(1):37-42

Standard residual pesticides applied to US military materials such as camouflage netting can reduce mosquito biting pressure in the field but may contribute to the evolution of resistance. However, residual applications of a spatial repellent such as transfluthrin could allow mosquitoes the opportunity to escape, only inducing mortality if insects linger, for example after becoming trapped in a treated tent. In this study we investigated the capability of transfluthrin on 2 types of US military material to reduce natural populations of disease vector mosquitoes in a cool-arid desert field environment in southern California. Read More

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http://dx.doi.org/10.2987/19-6894.1DOI Listing

Impact of the Insect Growth Regulator Pyriproxyfen on Immature Development, Fecundity, and Fertility of .

J Am Mosq Control Assoc 2020 Mar;36(1):11-15

Environmental Health Sciences Program, Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, 3403 Carol Belk Building, 300 Curry Court, Greenville, NC 27858.

is a vector of several arboviruses; however, control of this day-active species is difficult with ultra-low-volume insecticide treatments applied at dusk/dawn periods. In the current laboratory study, blood-fed were exposed to Archer (insect growth regulator AI: pyriproxyfen) residue in glass bottles (to approximate barrier treatment) and allowed to oviposit. Control mosquitoes were exposed to clean bottles. Read More

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http://dx.doi.org/10.2987/19-6893.1DOI Listing

Outside-in or Inside-out? A Randomized Controlled Trial of Two Empowerment Approaches for Family Caregivers of People with Schizophrenia.

Issues Ment Health Nurs 2020 Jun 4:1-12. Epub 2020 Jun 4.

East Kowloon Psychistric Center, Kwai Chung Hospital, Kowloon, Hong Kong.

Training-based intervention such as psychoeducational groups has become increasingly popular to empower family caregivers of people with schizophrenia, yet existing supportive programs for caregivers tend to focus more on the needs of the patients rather than the development of the caregivers. This study aimed to compare the outcomes of a skill-based empowerment psychoeducational group and an inner-resource enhancing empowerment narrative therapy group for family caregivers of people with schizophrenia. We conducted a randomized controlled trial with a longitudinal design. Read More

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http://dx.doi.org/10.1080/01612840.2020.1734992DOI Listing

Bacillus subtilis and Bacillus velezensis population dynamic and quantification of spores after inoculation on ornamental plants.

Can J Microbiol 2020 Jun 4. Epub 2020 Jun 4.

Universite de Sherbrooke, 7321, Biology , 2500 boul Université , Sherbrooke, Quebec, Canada , J1K 2R1 ;

Bacillus subtilis and Bacillus velezensis are used in organic agriculture as an alternative to chemical pesticides to fight against phytopathogen organisms. These Gram-positive soil-dwelling bacteria are able to resist harsh conditions and survive by differentiating into endospores. Few studies have examined how bacterial populations change on plants over time, and if they remain active or enter a dormant state. Read More

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http://dx.doi.org/10.1139/cjm-2020-0174DOI Listing

Occurrence of Aspergillus niger strains on polychrome cotton painting and their elimination by anoxic treatment.

Can J Microbiol 2020 Jun 4. Epub 2020 Jun 4.

Universidade Federal de Minas Gerais, 28114, Department of Microbiology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil ;

This study aimed to isolate and identify the population of filamentous fungi colonizing a cotton painting by a Brazilian private artwork collector, whose conservation status was compromised and showed signs of biodeterioration due to dirt accumulation and microbial metabolism. In addition, microbiological techniques such as cultivation dependent approach and molecular biology were used to identify microbial populations and to eliminate their metabolic action. For this, the non-destructive anoxic atmosphere technique was used, in which the microbial metabolism was affected by the absence of oxygen. Read More

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http://dx.doi.org/10.1139/cjm-2020-0173DOI Listing
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