Appl Environ Microbiol 2017 Nov 17. Epub 2017 Nov 17.
School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, TW20 OEX, UK.
Genetic manipulation of bacterial spores of the genus Bacillus has shown potential for vaccination and for delivery of drugs or enzymes. Remarkably, proteins displayed on the spore surface retain activity and generally are not degraded. The heat stability of spores coupled with their desiccation resistance makes them suitable for delivery to humans or to animals by the oral route. Read More