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Adv Healthc Mater 2022 May 24:e2200665. Epub 2022 May 24.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Enriching the application of multifunctional dendritic mesoporous organosilica (DMOS) is still challenges in anti-cancer research. Herein, we co-incorporated manganese ions, iron ions, or cobalt ions and tetrasulfide bond into the framework of DMOS to yield multifunctional nanoparticles denoted as Mn-DMOS, Fe-DMOS, or Co-DMOS by directly doping metal ions during the synthetic process. Due to co-incorporation of metal ions and tetrasulfide bond, these designed nanocarriers have more functions rather than only for cargo delivery. Read More

Ann Rheum Dis 2022 May 24. Epub 2022 May 24.

Department of Internal Medicine and Rheumatology, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.

Objective: Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes underlying the 110 SLE loci that were identified in the latest East Asian GWAS meta-analysis.

Methods: We built gene expression predictive models in blood B cells, CD4 and CD8 T cells, monocytes, natural killer cells and peripheral blood cells of 105 Japanese individuals. Read More

Eur J Hosp Pharm 2022 May 24. Epub 2022 May 24.

University of Queensland Centre for Clinical Research, Faculty of Medicine,the University of Queensland, Herston, Queensland, Australia.

Objective: To evaluate the stability of temocillin solution in two elastomeric infusion devices - Easypump II LT 270-27- S and Dosi-Fusor L25915-250D1 for OPAT administration during 14 days of 5°C±3°C fridge storage followed by 24 hour exposure at an in-use temperature of 32°C, when reconstituted with 0.3% citrate buffer at pH7.

Methods: Stability testing was conducted in accordance with standard protocols in the UK National Health Service Yellow Cover Document (YCD). Read More

Org Lett 2022 May 24. Epub 2022 May 24.

Universidade Federal do Paraná, Departamento de Química, 81531-990 Curitiba, Brazil.

Investigation of the contents of the scent glands of the heliconiine butterfly via gas chromatography/electroantennography revealed an unprecedented active compound. The males transfer this compound to females during mating. The structure of (2,6,10)-2,6-dimethyl-6-undecen-10-olide, a derivative of geranylacetone, was proposed on the basis of infrared and mass spectrometry spectra and microderivatization and confirmed by racemic and stereoselective syntheses. Read More

Vet Comp Orthop Traumatol 2022 May 24. Epub 2022 May 24.

Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, University of Marília (UNIMAR), Marília, SP, Brazil.

Objective:  The aim of this study was to evaluate the influence of near-cortical over-drilling holes on the mechanical behaviour of locking plate constructs applied in maned wolf's femur by using mechanical testing and finite element method (FEM).

Study Design:  Seven pairs of adult maned wolves () femur bones were randomly distributed into four groups. In all groups, a 3. Read More

Methods Inf Med 2022 May 24. Epub 2022 May 24.

DigiHealth Institute, Neu-Ulm University of Applied Sciences, Neu-Ulm, Germany.

Background: Management of child healthcare can be negatively affected by incomplete recording, low data quality, and lack of data integration of health management information system (HMIS) to support decision making and public health program needs. Given the importance of identifying key determinants of child health via capturing and integrating accurate and high-quality information, we aim to address this gap through the development and testing requirements for an integrated child health information system.

Subjects And Method: A five-phase design thinking approach including empathizing, defining, ideation, prototyping, and testing was applied. Read More

Environ Pollut 2022 May 21:119514. Epub 2022 May 21.

MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing, 102206, China. Electronic address:

The recently recognized adverse environmental and toxic effects of neonicotinoid insecticides (NNIs) on non-target organisms are alarming. A comprehensive design, screening, and regulatory system was developed to generate NNI derivatives and mutant receptors with selective-ecotoxicological effects to overcome such adverse effects. For ligand design, taking ACE-09 derivative as an example, the toxicity on non-target animals (aboveground: bees; underground: earthworms), plant absorption, and soil absorption decreased by 4. Read More

Int J Biol Macromol 2022 May 21. Epub 2022 May 21.

College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:

With the increasing attention to food preservation and environmental safety, there is great pressing demand to explore novel edible and environment-friendly food packaging films. In the present study, a new kind natural curdlan (CD) film was developed with the addition of bacterial cellulose (BC) and cinnamon essential oil (CEO) at 2% and 10% (w/w) amounts, with regard to improve mechanical properties and investigate potential food applications. Our results showed that the tensile strength, the crystallinity and the thermal stability of the CD/BC blending film were improved, while the water vapor permeability, moisture content and the lightness were reduced. Read More

Int J Pharm 2022 May 21:121826. Epub 2022 May 21.

Research Institute for Fragrance Materials Inc (RIFM, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.

In vitro human skin permeation and distribution of the fragrance material linalool (3,7-dimethyl-1,6-octadien-3-ol, CAS No. 78-70-6) following application in a range of single and mixed vehicles was determined, under unoccluded and occluded conditions, using human epidermal membranes. Vehicles were (70/30 v/v) ethanol[EtOH]/water, dipropyleneglycol [DPG], diethyl phthalate [DEP], (25/75 v/v) EtOH/DEP, (25/75 v/v) EtOH/DPG and petrolatum. Read More

Toxicon 2022 May 21. Epub 2022 May 21.

Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, 10400, Thailand. Electronic address:

Snakebite envenomation is an important medical problem in numerous parts of the world causing about 2.7 million envenomations and between 81,000 and 138,000 deaths ayear. Antivenoms (AVs) are time proven effective therapeutics for snakebite envenomation. Read More

Brain Stimul 2022 May 21. Epub 2022 May 21.

CHU de Nantes, Clinical Investigation Unit 18, Department of Addictology and Consultation-liaison Psychiatry, F-44000, Nantes, France; University of Nantes, Laboratory 'Movement, Interactions, Performance' (E.A. 4334), F-44000, Nantes, France.

Background: Recently intermittent theta burst stimulation (iTBS) proved to be non-inferior to conventional repetitive transcranial magnetic stimulation (10 Hz rTMS) in unipolar depression after failure of one antidepressant trial, but to date no randomized control trial assessed the ability of iTBS to improve depression level and quality of life in more resistant features of depression with a long-term (6 month) follow-up in comparison to 10 Hz rTMS.

Objectives/hypothesis: The aim of our study was to compare the efficacy of 10 Hz rTMS and iTBS in treatment-resistant unipolar depression on response rates (50% decrease of MADRS scores at one month from baseline) and change in quality of life during a 6-month follow-up. In addition, we investigated whether some clinical features at baseline were associated with the response in the different groups. Read More

Photodiagnosis Photodyn Ther 2022 May 21:102924. Epub 2022 May 21.

Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan. Electronic address:

In spite of the massive developments in various molecular approaches, the world is still facing major challenges in diagnosing infectious diseases triggered by bacteria. Identification of such causative pathogens at an earlier stage and with an acceptable degree of sensitivity and specificity play major role in initiating proper treatment. In this study the performance of multilayer perceptron (MLP) algorithm on the Raman Spectroscopic data of tuberculosis disease have been evaluated. Read More

Acta Biomater 2022 May 21. Epub 2022 May 21.

Chair of Solid Mechanics, University of Wuppertal, 42119 Wuppertal, Germany; Wuppertal Center for Smart Materials & Systems, University of Wuppertal, 42119 Wuppertal, Germany. Electronic address:

Nacre's superior mechanical properties and failure behavior strongly depend on orientation due to its brick-and-mortar microstructure. In this work, the anisotropic microscopic deformation and the resulting macroscopic mechanical properties are evaluated under different loading conditions. Our in situ transmission electron microscopy deformation experiments and finite element simulations reveal that nacre possesses enhanced indentation resistance along the direction normal to the tablets through delocalization of indentation-induced deformation by taking advantage of its layered structure. Read More

Gene 2022 May 21:146556. Epub 2022 May 21.

Department of Genetics, University of Georgia, GA 30606, United States.

The hierarchical relationship between transcription factors, associated proteins, and their target genes is defined by a gene regulatory network (GRN). GRNs allow us to understand how the genotype and environment of a plant are incorporated to control the downstream physiological responses. During plant growth or environmental acclimatization, GRNs are diverse and can be differently regulated across tissue types and organs. Read More

J Struct Biol 2022 May 21:107871. Epub 2022 May 21.

Department of Applied Mathematics, School of Mathematical Sciences, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:

Particle picking is currently a critical step in the cryo-electron microscopy single particle reconstruction pipeline. Contaminations in the acquired micrographs severely degrade the performance of particle pickers, resulting is many "non-particles" in the collected stack of particles. In this paper, we present ASOCEM (Automatic Segmentation Of Contaminations in cryo-EM), an automatic method to detect and segment contaminations, which requires as an input only the approximate particle size. Read More

Methods 2022 May 21. Epub 2022 May 21.

Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA; Department of Computer Science, Purdue University, West Lafayette, IN, 47907, USA; Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, 47907, USA. Electronic address:

Intrinsically Disordered Proteins (IDPs) are a class of proteins in which at least some region of the protein does not possess any stable structure in solution in the physiological condition but may adopt an ordered structure upon binding to a globular receptor. These IDP-receptor complexes are thus subject to protein complex modeling in which computational techniques are applied to accurately reproduce the IDP ligand-receptor interactions. This often exists in the form of protein docking, in which the 3D structures of both the subunits are known, but the position of the ligand relative to the receptor is not. Read More

Neuroimage 2022 May 21:119329. Epub 2022 May 21.

Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USA.

In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. Read More

J Affect Disord 2022 May 21. Epub 2022 May 21.

Department of Health Sciences, University of Florence, via di San Salvi 12, 50135 Florence, Italy; Department of Psychiatry & Neuropsychology, Maastricht University, PO Box 616, Maastricht, the Netherlands. Electronic address:

Background: The assessment of psychological well-being and euthymia represents an emerging issue in clinical psychology and psychiatry. Rating scales and indices such as the 5-item version of the World Health Organization Well-Being Index (WHO-5) and the Euthymia Scale (ES) were developed but insufficient attention has been devoted to the evaluation of their cross-cultural validity. This is the first study using Clinimetric Patient-Reported Outcome Measures (CLIPROM) criteria to assess cross-cultural validity and sensitivity of five different versions of the WHO-5 and ES. Read More

Fish Shellfish Immunol 2022 May 21. Epub 2022 May 21.

Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan, Taiwan; International Center for Scientific Development of Shrimp Aquaculture, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Peritrophins are peritrophic membrane (PM) proteins that can interact with chitin fibers via chitin-binding domains. Peritrophins have essential roles in providing porosity and strength to the PM that lines the shrimp midgut. Acute hepatopancreatic necrosis disease (AHPND), caused by strains of V. Read More

Sci Total Environ 2022 May 21:156142. Epub 2022 May 21.

Northern Region Persistent Organic Pollutant Control (NRPOP) Laboratory, Faculty of Engineering and Applied Science, Memorial University, St. John's, NL A1B 3X5, Canada.

Microplastics (MPs) have been found in oil-polluted oceans, but studies on MPs and oil were still focused on their respective transport, biodegradation, and bioaccumulation. The interactions between MPs and oil in the marine environment remain unknown. MPs would incorporate with oil to form MP-oil agglomerate (MOA), the behaviors of MOA were thus discussed in this study. Read More

Sci Total Environ 2022 May 21:156159. Epub 2022 May 21.

Department of Biological and Agricultural Engineering & Texas A&M AgriLife Research Center, Texas A&M University, TX 77843, USA; Department of Wildlife, and Natural Resources, Tarleton State University, TX 76401, USA. Electronic address:

To prevent possible secondary pollution from phosphorus-loaded biochar (BC) in agricultural systems, this study investigated the sustainable use of Ca(OH) modified wood biochars (Ca-BCs) for P recovery while significantly lowering the tetracycline (TC) adsorption onto Ca-BCs. Ca-BCs were prepared via calcination of mixtures of Ca(OH) and wood BC under 100-500 °C for removing P and TC from water. Compared to the pristine BC (without Ca(OH) modification), Ca-BC100 (Ca-BC prepared at 100 °C) showed a significant increase of P adsorption capacity from 4. Read More

Anal Biochem 2022 May 21:114746. Epub 2022 May 21.

School of Science, Xi'an Polytechnic University, Xi'an, 710048, PR China.

N4-methylcytosine (4mC) is an important and common methylation which widely exists in prokaryotes. It plays a crucial role in correcting DNA replication errors and protecting host DNA against degradation by restrictive enzymes. Hence, the accurate identification for 4mC sites is greatly significant for understanding biological functions and treating gene diseases. Read More

Chemosphere 2022 May 21:135036. Epub 2022 May 21.

Biofuels Institute, School of Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu Province, China. Electronic address:

The soil microbial fuel cell (SMFC) is a new device that was originally designed to generate electricity from organic matter in soil using microorganisms. Currently, SMFC based biosensors are emerging as a new and promising research direction for real-time and rapid monitoring of soil quality or soil pollution. Compared to conventional biosensors, SMFC based biosensors exhibit advantages such as low-cost, simple design, in-situ, and long-term self-powering monitoring, which makes it become attractive devices for in-situ long-term soil quality or soil pollution monitoring. Read More

Environ Res 2022 May 21:113445. Epub 2022 May 21.

Department of Chemistry, Vaal University of Technology, Vanderbijlpark, 1911, South Africa.

Based on the premise that aqueous anions of hexavalent chromium (Cr(VI)) are capable of electrostatic interaction with cationic and polar active sites, acid-washed Madacamia nutshell biomass was sequentially treated with diethylenetriamine (DETA) and maleic anhydride (MA) to graft poly(diethylenetriamine-co-maleic anhydride). By displaying a new peak at 1685 cm ascribed to amide CO stretching vibrations, Fourier transform infrared spectroscopy highlighted the formation of amide groups through reaction of DETA with carboxyl groups on the biomass surface. Scanning electron microscopic images of the MA-modified biomass displayed polymeric growths attributed to copolymerization of DETA with MA. Read More

Microvasc Res 2022 May 21:104385. Epub 2022 May 21.

Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address:

Exosomes are endogenous nanoparticles with a lipid bilayer membrane whose natural function as carriers of biological materials has attracted much attention. The ability of exosomes to cross biological barriers, especially the blood-brain barrier, has highlighted them as tools of drug delivery to brain tumors. In a previous study, we isolated and characterized exosomes derived from human endometrial mesenchymal stem cells (hEnMSCs exosomes). Read More

Neuron 2022 May 18. Epub 2022 May 18.

Optophysiology Lab, Institute of Biology III, Albert-Ludwigs-University, 79110 Freiburg, Germany; IMBIT//BrainLinks-BrainTools, Albert-Ludwigs-University, 79110 Freiburg, Germany; Bernstein Center Freiburg, Albert-Ludwigs-University, 79110 Freiburg, Germany. Electronic address:

The impact of spontaneous movements on neuronal activity has created the need to quantify behavior. We present a versatile framework to directly capture the 3D motion of freely definable body points in a marker-free manner with high precision and reliability. Combining the tracking with neural recordings revealed multiplexing of information in the motor cortex neurons of freely moving rats. Read More

Phys Med Biol 2022 May 24. Epub 2022 May 24.

University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2C4, CANADA.

Objective: Machine learning (ML) based radiation treatment (RT) planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising importance of magnetic resonance (MR) based treatment planning workflows, we sought to determine if an ML based treatment planning model, trained on computed tomography (CT) imaging, could be applied to MR through domain adaptation.

Methods: In this study, MR and CT imaging was collected from 55 prostate cancer patients treated on an MR linear accelerator. Read More

Environ Int 2022 May 18;165:107291. Epub 2022 May 18.

MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing 102206, China. Electronic address:

This study explored the combined disruption mechanism of polychlorinated naphthalenes (PCNs) on the three key receptors (estrogen receptor, thyroid receptor, and adrenoceptor) of the human endocrine system. The intensity of PCN endocrine disruption on these receptors was first determined using a molecular docking method. A comprehensive index of PCN endocrine disruption to human was quantified by analytic hierarchy process and fuzzy analysis. Read More

Water Res 2022 May 13;219:118597. Epub 2022 May 13.

Department of Civil and Environmental Engineering, Penn State University, 231Q Sackett Building, University Park, PA 16802, United States. Electronic address:

Microbial electrosynthesis (MES) cells use renewable energy to convert carbon dioxide into valuable chemical products such as methane and acetate, but chemical production rates are low and pH changes can adversely impact biocathodes. To overcome these limitations, an MES reactor was designed with a zero-gap electrode configuration with a cation exchange membrane (CEM) to achieve a low internal resistance, and a vapor-fed electrode to minimize pH changes. Liquid catholyte was pumped through a carbon felt cathode inoculated with anaerobic digester sludge, with humidified N gas flowing over the abiotic anode (Ti or C with a Pt catalyst) to drive water splitting. Read More