927,329 results match your criteria Applied Psychophysiology and Biofeedback [Journal]


Translating the application of TGF-β1, chondroitinase-ABC, and lysyl oxidase-like 2 for mechanically robust tissue-engineered human neocartilage.

J Tissue Eng Regen Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.

Strategies to overcome the limited availability of human articular chondrocytes (hACs) and their tendency to dedifferentiate during expansion are required to advance their clinical use and to engineer functional cartilage on par with native articular cartilage. This work sought to determine whether a biochemical factor, TGF-β1 (T), a biophysical agent, chondroitinase-ABC (C), and a collagen crosslinking enzyme, lysyl oxidase-like 2 (L) are efficacious in forming three-dimensional human neocartilage from expanded human articular chondrocytes. Among the treatment regimens, the combination of the three stimuli (TCL treatment) led to the most robust glycosaminoglycan (GAG) content, total collagen content, and type II collagen production. Read More

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December 2018

A Novel Method for Generation of a Fingerprint Using Electronic Nose on the Example of Rapeseed Spoilage.

J Food Sci 2018 Dec 17. Epub 2018 Dec 17.

Inst. of Agrophysics, Polish Academy of Sciences, ul. Doswiadczalna 4, 20-290, Lublin, Poland.

The paper presents application of a new three-parameter method for identification of volatile organic compounds (VOCs) and creation of fingerprints based on the impregnation time (t ), cleaning time (t ), and maximum response ([ΔR/R] ) of chemically sensing sensors for detecting spoilage of agricultural commodities. The novelty of this method consists in the use of two additional parameters: an impregnation time and a cleaning time for the first time. An Agrinose built of eight metal oxide semiconductors was used for identification of loss in the rapeseed quality during a short period of storage after harvest. Read More

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December 2018
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Is Early Compression Therapy after Perforator Flap Safe and Reliable?

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background:  Due to the concern of circulation compromise, many surgeons hesitate to dangle or challenge the flap in the early postoperative phase. In our experience, early compression may have advantages such as collapse of dead space, evacuation of hematoma, reduction of edema, and stabilization of flap when ambulating. In this study, the effect of early compression of flaps with regard to flap physiology and outcome is evaluated. Read More

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December 2018

Flow-Through Flaps in the Absence of an Arterial Gap for Extremity Defect Reconstruction: Minimizing the Donor-Site Morbidity.

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background:  The use of flow-through flaps was popularized in the early 1990s by Costa, Soutar and Lamberty in cases where an arterial gap was present or a major artery of the limb was damaged. We hypothesized that flow-through flaps can be used in all extremity reconstruction cases, where there is an indication for a free-flap, irrespective of the existence of arterial defect due to its many advantages while not increasing the flap loss significantly.

Methods:  A retrospective study was performed by examining patient status and surgery reports of all patients who underwent extremity reconstruction with a flow-through flap from January 2011 to January 2016. Read More

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December 2018

Influence of edge magnetization and electric fields on zigzag silicene, germanene and stanene nanoribbons.

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Department of Applied Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Nagoya, JAPAN.

Using a multi-orbital tight-binding model, we have studied the edge states of zigzag silicene, germanene, and stanene nanoribbons (ZSiNRs, ZGeNRs and ZSnNRs, respectively) in the presence of the Coulomb interaction and a vertical electric field. The resulting edge states have non-linear energy dispersions due to multi-orbital effects, and the nanoribbons show induced magnetization at the edges. Owing to this non-linear dispersion, ZSiNRs, ZGeNRs and ZSnNRs may not provide superior performance in field effect transistors, as has been proposed from single-orbital tight-binding model calculations. Read More

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December 2018

Reply to Comment on 'Nonlocal statistical field theory of dipolar particles in electrolyte solutions'.

Authors:
Yury A Budkov

J Phys Condens Matter 2018 Dec 17. Epub 2018 Dec 17.

Applied mathematics, National Research University Higher School of Economics, Moscow, RUSSIAN FEDERATION.

We reply to the comment on our paper by Yu.A. Budkov (2018 J. Read More

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December 2018

Coupling stable isotopes and water chemistry to assess the role of hydrological and biogeochemical processes on riverine nitrogen sources.

Water Res 2018 Dec 6;150:418-430. Epub 2018 Dec 6.

College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Ministry of Education Key Laboratory of Environment Remediation and Ecological Health, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Accurate source identification is critical for optimizing water pollution control strategies. Although the dual stable isotope (N-NO/O-NO) approach has been widely applied for differentiating riverine nitrogen (N) sources, the relatively short-term (<1 yr) N-NO/O-NO records typically used in previous studies often hinders rigorous assessment due to high temporal variability associated with watershed N dynamics. Estimated contributions of legacy N sources in soils and groundwater to riverine N export by modeling approaches in many previous studies also lack validation from complementary information, such as multiple stable isotopes. Read More

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December 2018

Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models.

Environ Int 2018 Dec 14;123:325-336. Epub 2018 Dec 14.

State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Background: The evaluation of the chemical impact on human health is usually constrained to the analysis of the health effects of exposure to a single chemical or a group of similar chemicals at one time. The effects of chemical mixtures are seldom analyzed. In this study, we applied three statistical models to assess the association between the exposure to a mixture of seven xenobiotics (three phthalate metabolites, two phenols, and two pesticides) and obesity. Read More

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December 2018

Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy.

Environ Int 2018 Dec 14;123:318-324. Epub 2018 Dec 14.

Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Background: Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited.

Objective: To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Read More

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December 2018

Assessment of forest fire impacts on carbonaceous aerosols using complementary molecular marker receptor models at two urban locations in California's San Joaquin Valley.

Environ Pollut 2018 Dec 7;246:274-283. Epub 2018 Dec 7.

Department of Civil & Environmental Engineering, University of Wisconsin-Madison, Madison, 53705, USA; Environmental Chemistry and Technology, University of Wisconsin-Madison, Madison, 53706, USA. Electronic address:

Two hundred sixty-three fine particulate matter (PM) samples were collected over fourteen months in Fresno and Bakersfield, California. Samples were analyzed for organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC), and 160 organic molecular markers. Chemical Mass Balance (CMB) and Positive Matrix Factorization (PMF) source apportionment models were applied to the results in order to understand monthly and seasonal source contributions to PM OC. Read More

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December 2018

Soil fumigation alters adsorption and degradation behavior of pesticides in soil.

Environ Pollut 2018 Dec 3;246:264-273. Epub 2018 Dec 3.

Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China; Beijing Innovation Consortium of Agriculture Research System, Beijing, 100193, China. Electronic address:

Many crops are produced using soil fumigation and chemical pesticides to control soil-borne fungi and bacterial diseases, nematodes and weeds. Fumigation of soil, however, may alter its ability to adsorb, degrade and volatilize pesticides, which can then change the potential for pesticides to leach into groundwater. Soil adsorption kinetics, Freundlich isothermal adsorption and pesticide degradation techniques were used to determine the potential for pesticides to pollute groundwater in fumigated soil. Read More

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December 2018
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Evidences of different meteorological patterns governing Be and Pb surface levels in the southern Iberian Peninsula.

J Environ Radioact 2018 Dec 14;198:1-10. Epub 2018 Dec 14.

Department of Integrated Sciences, Area of Applied Physics, University of Huelva, 21071, Huelva, Spain; Research Center on Natural Resources, Health and the Environment (RENSMA), University of Huelva, 21071, Huelva, Spain.

Be, Pb and PM levels in surface air have been simultaneously measured at two sampling sites in the southern Iberian Peninsula for a period of two years. Each site covers one different meteorological area of the Guadalquivir valley, from the mouth (Huelva) to the middle point (Cordoba). The objective of the present study is to analyse the spatial variability of both natural radionuclides, and to identify and characterise the meteorological patterns associated with similar and different surface concentration levels in this complex region. Read More

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December 2018

Protein biochips based on macroporous polymer supports: Material properties and analytical potential.

J Pharm Biomed Anal 2018 Dec 10;165:242-250. Epub 2018 Dec 10.

Institute of Chemistry, Saint-Petersburg State University, Universitetsky pr. 26, Petrodvorez, 198584, St. Petersburg, Russia; Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004, St. Petersburg, Russia.

A series of rigid macroporous polymer layers differed by hydrophobic-hydrophilic properties was synthesized in situ in preliminary fabricated wells and applied as the platforms for protein biochips. Scanning electron microscopy, etalon porosimetry and BET analysis were used for materials characterization. The comparison of analytical efficiency of the developed platforms allowed for the choice of the most optimal polymer, as well as the evaluation of impact of material porous properties. Read More

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December 2018

Long-term ketone body therapy of severe multiple acyl-CoA dehydrogenase deficiency: A case report.

Nutrition 2018 Oct 22;60:122-128. Epub 2018 Oct 22.

University Hospital Muenster, Department of Pediatrics, Muenster, Germany.

Objectives: Multiple acyl-CoA dehydrogenase deficiency (MADD) is the most severe disorder of mitochondrial fatty acid β-oxidation. Treatment of this disorder is difficult because the functional loss of the electron transfer flavoprotein makes energy supply from fatty acids impossible. Acetyl-CoA, provided by exogenous ketone bodies such as NaßHB, is the only treatment option in severe cases. Read More

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October 2018

QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test.

Aquat Toxicol 2018 Dec 5;207:110-119. Epub 2018 Dec 5.

UFZ - Helmholtz Centre for Environmental Research, Permoserstr. 15, 04318 Leipzig, Germany; Eberhard Karls University Tübingen, Center for Applied Geoscience, Environmental Toxicology Hölderlinstr. 12, 72074, Tübingen, Germany.

The fish embryo toxicity (FET) test with the zebrafish Danio rerio is widely used to assess the acute toxicity of chemicals thereby serving as animal alternative to the acute fish toxicity test. The minimal toxicity of neutral chemicals in the FET can be predicted with a previously published Quantitative Structure-Activity Relationship (QSAR) based on the liposome-water partition coefficient K. Such a QSAR may serve to plan toxicity testing and to evaluate whether an observed effect is caused by a specific mode of action (MoA). Read More

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December 2018

Predicting cadmium toxicity with the kinetics of phytochelatin induction in a marine diatom.

Aquat Toxicol 2018 Dec 11;207:101-109. Epub 2018 Dec 11.

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China. Electronic address:

Phytochelatin (PC) synthesis is thought to be a rapid and specific response to metal exposure in marine phytoplankton, but its potential as a predictor of metal toxicity is far from conclusive. Thus this research examines the bioaccumulation, PC induction, and toxicity of Cadmium (Cd) in Thalassiosira weissflogii, a coastal diatom under varying nutrient conditions. Nitrogen limitation strongly inhibited Cd uptake and PC induction at the same [Cd] level, and increased metal sensitivity. Read More

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December 2018

Compounding matters: Event-related potential evidence for early semantic access to compound words.

Cognition 2018 Dec 14;184:44-52. Epub 2018 Dec 14.

Department of Psychology and the Jack and Nora Walker Centre for Lifespan Development Research, Brock University, Canada.

Reading words in a native language triggers a largely obligatory cognitive process that we accept as leading to comprehension of the word - we cannot suppress our understanding of word meaning. In this study, we investigated the early stages of this comprehension process by means of event-related potentials (ERPs) to identify when this processing of meaning - that is, semantic processing - first occurs. We report that, when processing visually presented compound words, semantic access at some level occurs as early as the P100 and persists through to the N400. Read More

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December 2018

Aggregation of chlorophyll a induced in self-assembled membranes composed of DMPC and DHPC.

Colloids Surf B Biointerfaces 2018 Dec 5;175:403-408. Epub 2018 Dec 5.

Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan. Electronic address:

The J-aggregate of chlorophyll a (Chla) functions as a light-harvesting antenna in natural systems. In this study, we employed the phospholipid membranes composed of longer-chain 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and shorter-chain 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC), as a platform to induce Chla aggregates. The DMPC/DHPC assembly at the mixing ratio (q) = 1. Read More

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December 2018

Cobalt tetracarboxyl phthalocyanine-manganese octahedral molecular sieve (OMS-2) as a heterogeneous catalyst of peroxymonosulfate for degradation of diclofenac.

Chemosphere 2018 Dec 5;219:756-765. Epub 2018 Dec 5.

Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address:

A composite of cobalt tetracarboxyl phthalocyanine and amino-functionalized manganese octahedral molecular sieve (CNOMS-2) was synthesized in a simple way, and applied for degrading diclofenac in aqueous media by catalyzing of peroxymonosulfate heterogeneously. The experiment results revealed that the CNOMS-2/PMS system was highly efficient for DCF degradation in the pH range of 5-9, and the mechanism involved the generation of OH, SO⁻ and O by the activation of PMS. The main reactive oxygen species was found to be O by radical scavenging experiments and electron paramagnetic resonance (EPR) spectroscopy. Read More

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December 2018

Characterizing the effect of Poast on Chlorella vulgaris, a non-target organism.

Chemosphere 2018 Dec 8;219:704-712. Epub 2018 Dec 8.

Marshall University Department of Chemistry, One John Marshall Dr., Huntington, WV, 25755, USA. Electronic address:

Herbicides may cause unexpected damage to non-target organisms as it is challenging to predict undesirable biotic interactions. Poast is a widely used herbicide formulation that contains sethoxydim and targets the acetyl-CoA carboxylase of perennial grasses. In this study, Chlorella vulgaris, a unicellular green microalga, was exposed to a 0. Read More

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December 2018

Long-term effects of chlorantraniliprole reduced risk insecticide applied as seed treatment on lady beetle Harmonia axyridis (Coleoptera: Coccinellidae).

Chemosphere 2018 Dec 10;219:678-683. Epub 2018 Dec 10.

Departamento de Entomologia, Universidade Federal de Lavras, Lavras, MG, Brazil.

Chlorantraniliprole (CAP) is a reduced risk insecticide, which used as seed treatment in many crops. However, CAP residues can contaminate pollen and nectar, becoming a potential risk to beneficial arthropods. The aims of this study were to (1) determine the non-target effects of CAP seed treatment of cotton on Harmonia axyridis (Coleoptera: Coccinellidae) over two generations, and (2) assess the ability of the lady beetles to avoid plants grown from treated seeds. Read More

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December 2018

Changes in the pattern of polycyclic aromatic hydrocarbons in soil treated with biochar from a multiyear field experiment.

Chemosphere 2018 Nov 27;219:662-670. Epub 2018 Nov 27.

Institute of Biometeorology (IBIMET), National Research Council (CNR), Via G. Caproni 8, 50145 Florence, Italy.

The influence of biochar added to an agricultural soil on polycyclic aromatic hydrocarbon (PAH) levels, PAH diagnostic ratios and soil properties was investigated in a five-year field experiment. The experiment was carried out in an Italian vineyard and included two biochar treatments: 16.5 t ha of biochar applied in 2009 (soil B); 16. Read More

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November 2018

Mechanism and kinetics studies of the atmospheric oxidation of p,p'-Dicofol by OH and NO radicals.

Chemosphere 2018 Dec 10;219:645-654. Epub 2018 Dec 10.

Environment Research Institute, Shandong University, Jinan, 250100, China.

As an effective organochlorine pesticide, Dicofol has been extensively applied in more than 30 countries for protecting over 60 different crops. Considering its large consumption and potential adverse effect on human health (endocrine disrupting and carcinogenicity), the fate of Dicofol sprayed into the air is of public concern. In this study, we conducted a comprehensive study on the reaction mechanisms of p,p'-Dicofol with OH and NO radicals using DFT method. Read More

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December 2018

Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A.

Ecotoxicol Environ Saf 2018 Dec 14;170:495-501. Epub 2018 Dec 14.

State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Halogenated bisphenol A analogues (X-BPA) have been widely used in industrial production, such as flame retardant. Although BPA exposure was found to result in cytotoxicity, toxicity of X-BPA and molecular mechanism remain under-explored. In this study, we employed human breast cancer cell as a model to investigate the concentration-dependent toxicity and underlying mechanisms of tetrabromo bisphenol A (TBBPA) and tetrachloro bisphenol A (TCBPA). Read More

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December 2018

Mechanistic modelling of Radium-223 treatment of bone metastases.

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.

Introduction: Despite the effectiveness of RaCl for treating patients with symptomatic bone metastatic disease, its mechanisms of action are still unclear. Even established dosimetric approaches differ considerably in their conclusions. In silico tumour models bring a new perspective to this as they can quantitatively simulate the interaction of α-particles with the target(s). Read More

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December 2018

Understanding the transition from water to land: Insights from multi-omic analyses of the perivitelline fluid of apple snail eggs.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Hong Kong Baptist University, Hong Kong, China; HKBU Institute of Research and Continuing Education, Shenzhen, China. Electronic address:

Most gastropods deposit their eggs either on land or underwater, but the family Ampullariidae includes members that exhibit both underwater and aerial oviposition, making it an ideal model for understanding mechanisms underlying the evolutionary transition from water to land. We applied SDS-PAGE and LC-MS/MS to analyse the proteome of the egg perivitelline fluid (PVF) of Marisa cornuarietis - an aquatic ovipositing ampullariid. Comparison with the reported PVF proteomes of two aerial ovipositing ampullariids (Pomacea canaliculata and P. Read More

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December 2018
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Development of a Graft Inoculation Method and a Real-Time RT-PCR Assay for Monitoring Tomato chlorosis virus Infection in Tomato.

J Virol Methods 2018 Dec 14. Epub 2018 Dec 14.

Applied Sciences University of Isparta, Faculty of Agricultural Sciences and Technologies, Department of Agricultural Biotechnology, 32260, Isparta, Turkey.

A graft inoculation method coupled with RT-qPCR was developed for monitoring ToCV infection in tomato plants. Ten seed-grown tomato seedlings were graft inoculated with phloem tissue-containing stem segments from a ToCV-infected tomato plants. Another group of tomato seedling were grafted with similar stem segments from a healthy tomato plant as mock inoculated control. Read More

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December 2018

Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting.

Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

Lung cancer remains the leading cause of cancer-related deaths despite recent breakthroughs in immunotherapy. The widely embraced cancer stem cell (CSC) theory has also been applied for lung cancer, postulating that an often small proportion of tumor cells with stem cell properties are responsible for tumor growth, therapeutic resistance and metastasis. The identification of these CSCs and underlying molecular maintenance mechanisms is considered to be absolutely necessary for developing therapies for their riddance, hence achieving remission. Read More

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December 2018

Capturing biochemical diversity in cassava (Manihot esculenta Crantz) through the application of metabolite profiling.

J Agric Food Chem 2018 Dec 17. Epub 2018 Dec 17.

Cassava (Manihot esculenta Crantz) is the predominant staple food in Sub-Saharan African (SSA) and an industrial crop in South East Asia. Despite focused breeding efforts for increased yield, resistance and nutritional value, cassava breeding has not advanced at the same rapidity as other staple crops. In the present study, metabolomic techniques were developed and implemented to characterize the chemotypes of selected cassava accessions and assess potential resources for the breeding program. Read More

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December 2018

Transformation of Imine Cages to Hydrocarbon Cages.

Angew Chem Int Ed Engl 2018 Dec 17. Epub 2018 Dec 17.

GERMANY.

In contrast to organic cages which are formed by exploiting dynamic covalent chemistry, such as boronic ester cages, imine cages or disulfide cages, those with a fully carbonaceous backbone are rarer. With the exception of alkyne metathesis based approaches, the vast majority of hydrocarbon cages needs to be synthesized by kinetic bond formation. This implies a multiple step synthesis and no correction mechanism in the final macrocyclization step - both responsible for low overall yields. Read More

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December 2018

Do male and female soccer players differ in helping? A study on prosocial behavior among young players.

PLoS One 2018 17;13(12):e0209168. Epub 2018 Dec 17.

Social and Organizational Psychology, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, The Netherlands.

Acting prosocially can be quite challenging in one of the most salient intergroup contexts in contemporary society: Soccer. When winning is the ultimate goal, balancing self-interest with helping a fellow player in distress can be a tough decision; yet it happens. To date, we know little about what motivates soccer players to offer such help in the heat of the game. Read More

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December 2018

Modified TCA/acetone precipitation of plant proteins for proteomic analysis.

PLoS One 2018 17;13(12):e0202238. Epub 2018 Dec 17.

State Key Laboratory of Wheat and Maize Crop Science, Collaborative Innovation Center of Henan Grain Crops, College of Life Sciences, Henan Agricultural University, Zhengzhou, China.

Protein extracts obtained from cells or tissues often require removal of interfering substances for the preparation of high-quality protein samples in proteomic analysis. A number of protein extraction methods have been applied to various biological samples. TCA/acetone precipitation and phenol extraction, a common method of protein extraction, is thought to minimize protein degradation and activity of proteases as well as reduce contaminants like salts and polyphenols. Read More

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December 2018

Increasing the diagnostic yield of exome sequencing by copy number variant analysis.

PLoS One 2018 17;13(12):e0209185. Epub 2018 Dec 17.

Department of Genetics, University of North Carolina, Chapel Hill, NC, United States of America.

As whole exome sequencing (WES) becomes more widely used in the clinical realm, a wealth of unanalyzed information will be routinely generated. Using WES read depth data to predict copy number variation (CNV) could extend the diagnostic utility of this previously underutilized data by providing clinically important information such as previously unsuspected deletions or duplications. We evaluated ExomeDepth, a free R package, in addition to an aneuploidy prediction method, to detect CNVs in WES data. Read More

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December 2018

The effectiveness of art therapy for anxiety in adults: A systematic review of randomised and non-randomised controlled trials.

PLoS One 2018 17;13(12):e0208716. Epub 2018 Dec 17.

Faculty of Health, University of Applied Sciences Leiden, Leiden, The Netherlands.

Background: Anxiety disorders are one of the most diagnosed mental health disorders. Common treatment consists of cognitive behavioral therapy and pharmacotherapy. In clinical practice, also art therapy is additionally provided to patients with anxiety (disorders), among others because treatment as usual is not sufficiently effective for a large group of patients. Read More

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December 2018

Insights into life after sport for Spanish Olympians: Gender and career path perspectives.

PLoS One 2018 17;13(12):e0209433. Epub 2018 Dec 17.

Department of Social Sciences Applied to Sport, Physical Activity and Leisure, Sport Sciences Faculty, Universidad Politécnica de Madrid, Madrid, Spain.

The aims of this study were: i) to examine if Dual Career (DC) pathways are independent of gender, ii) to evaluate whether those athletes who followed a DC experienced less difficulty in their integration into the labor force than the athletes devoted entirely to sport regardless of gender, as well as iii) to analyze whether the type of career path chosen was related with the current labor status, and if differences exist between men and women athletes. A quantitative, cross-sectional, and descriptive study was used based on an ad hoc questionnaire. Two-hundred and twenty-eight retired Olympic athletes completed a questionnaire. Read More

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December 2018

Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study.

PLoS One 2018 17;13(12):e0208042. Epub 2018 Dec 17.

Department of Medicine, University of California San Francisco/ San Francisco VA Medical Center, San Francisco, California, United States of America.

Background: Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study.

Methods And Results: We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. Read More

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December 2018

Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137.

PLoS One 2018 17;13(12):e0208732. Epub 2018 Dec 17.

Department of Chemistry, University of Iowa, Iowa City, Iowa, United States of America.

Hydrogen sulfide (H2S) is a key gasotransmitter in agriculture and has been reported to increase the growth of plants in the first two weeks and to mitigate the effects of environmental stressors. GYY-4137 is widely used in these studies because it slowly releases H2S, but there is disagreement as to whether it requires enzymes to release H2S. In this article we describe the release of H2S in water without enzymes and that it releases H2S faster in organic solvents than in water or when mixed in topsoil. Read More

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December 2018
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Automatic interpretation of otoliths using deep learning.

PLoS One 2018 17;13(12):e0204713. Epub 2018 Dec 17.

Institute of Marine Research, Bergen, Norway.

The age structure of a fish population has important implications for recruitment processes and population fluctuations, and is a key input to fisheries-assessment models. The current method of determining age structure relies on manually reading age from otoliths, and the process is labor intensive and dependent on specialist expertise. Recent advances in machine learning have provided methods that have been remarkably successful in a variety of settings, with potential to automate analysis that previously required manual curation. Read More

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December 2018

NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system.

PLoS Negl Trop Dis 2018 Dec 17;12(12):e0007045. Epub 2018 Dec 17.

Department of Nutrition, University of California, Davis, California, United States of America.

Background: Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment. Metabolomics of cerebrospinal fluid (CSF) was explored as a method of differentiating among neurological diseases causing EM using a single CSF sample.

Methodology/principal Findings: 1H NMR metabolomics was applied to CSF samples from 27 patients with a laboratory-confirmed disease, including Lyme disease or West Nile Virus meningoencephalitis, multiple sclerosis, rabies, or Histoplasma meningitis, and 25 controls. Read More

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December 2018

Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis.

PLoS One 2018 17;13(12):e0208905. Epub 2018 Dec 17.

Graduate School, University of Santo Tomas, Manila City, Philippines.

Background: Managing nephropathy associated with diabetes mellitus warrant investigation of relevant biomarkers in predicting this condition. Adiponectin (ADP) may hold promise as a biomarker for diabetic nephropathy (DN). In this study, we examine associations of ADP with DN by meta-analyzing relevant literature. Read More

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December 2018

regQTLs: Single nucleotide polymorphisms that modulate microRNA regulation of gene expression in tumors.

PLoS Genet 2018 Dec 17;14(12):e1007837. Epub 2018 Dec 17.

Biostatistics Division, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with trait diversity and disease susceptibility, yet their functional properties often remain unclear. It has been hypothesized that SNPs in microRNA binding sites may disrupt gene regulation by microRNAs (miRNAs), short non-coding RNAs that bind to mRNA and downregulate the target gene. While several studies have predicted the location of SNPs in miRNA binding sites, to date there has been no comprehensive analysis of their impact on miRNA regulation. Read More

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December 2018

Measuring Outcomes of Ethics Consultation: Empirical and Ethical Challenges.

Crit Care Med 2019 Jan;47(1):e67-e68

Institute for History and Ethics of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany University of Applied Sciences for Diakonia, Bielefeld, Germany; and Institute for educational and health-care research in the health sector (InBVG), Bielefeld University of Applied Sciences, Bielefeld, Germany Institute for Medical Ethics and History of Medicine, Ruhr-University Bochum, Bochum, Germany Centre for Social Science and Global Health University of Amsterdam, AHTC, Amsterdam, The Netherlands Department of Palliative Medicine, Munich University Hospital, LMU Munich, München, Germany.

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January 2019
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A Nonlinear Dynamic Systems Model of Psychotherapy: First Steps Toward Validation and the Role of External Input.

Nonlinear Dynamics Psychol Life Sci 2019 Jan;23(1):79-112

Paracelsus Medical University, Salzburg, Austria.

Mathematical modeling and computer simulations are important means to understand the mechanisms of psychotherapy. The challenge is to design models which not only predict outcome, but simulate the nonlinear trajectories of change. Another challenge is to validate them with empirical data. Read More

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January 2019

Letters.

J Wound Care 2018 Dec;27(12):892-893

Plasma Physicist, HAWK - University of Applied Sciences and Arts, Göttingen, and Application Center for Plasma and Photonics, Fraunhofer Institute for Surface Engineering and Thin Films IST, Göttingen, Germany.

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December 2018

Photodynamic therapy in infected venous and mixed leg ulcers: a pilot experience.

J Wound Care 2018 Dec;27(12):816-821

Consultant, Angiology Department, MD Barbantini Clinic, Lucca, Italy.

Objective:: To assess the tolerability and efficacy of photodynamic therapy (PDT) with RLP068, a novel phthalocyanine-derived photosensitiser, in controlling the bacterial load in different leg ulcers, due to vascular pathophysiology.

Method:: An observational study of patients with infected leg ulcers of different pathophysiology, admitted to the hospital for a skin grafting procedure, were included. All patients underwent two sessions of PDT at time zero and after 72 hours. Read More

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December 2018
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Cryopreserved amniotic membrane in the treatment of diabetic foot ulcers: a case series.

J Wound Care 2018 Dec;27(12):806-815

Department of General Surgery, Hospital Clínico Universitario Virgen de la Arrixaca. Biomedical Research Institute of Murcia (Instituto Murciano de Investigación Biosanitaria, IMIB-Arrixaca). El Palmar, Spain.

Objective:: The amniotic membrane (AM) is a tissue with low immunogenity and high therapeutic potential due to its anti-inflammatory, anti-fibrotic and antimicrobial effects. This paper describes the use of cryopreserved amniotic membrane allografts to treat diabetic foot ulcers (DFUs) in patients with diabetes.

Method:: In this case series, AM was processed to obtain a final medicinal product: cryopreserved amniotic membrane. Read More

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December 2018

Cost-Utility Study of the Economics of Bunion Correction Surgery.

Foot Ankle Int 2018 Dec 17:1071100718815663. Epub 2018 Dec 17.

3 Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.

Background:: Bunion correction surgery is a very common procedure to improve patients' pain and physical function attributable to a misaligned first metatarsophalangeal joint. The objective of this study was to apply a health utility framework to estimate the cost utility of bunion correction surgery.

Methods:: Patients were prospectively recruited from the population of patients seen in a lower-extremity orthopedic clinic and scheduled for isolated bunion surgery. Read More

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December 2018

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: The Sympathetic activity and Ambulatory Blood Pressure in Africans study.

Diab Vasc Dis Res 2018 Dec 17:1479164118816221. Epub 2018 Dec 17.

1 Hypertension in Africa Research Team (HART) and School for Physiology, Nutrition and Consumer Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Objective:: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort.

Methods:: Black and White teachers (N = 338, aged 20-63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Read More

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December 2018

Combining pair-density functional theory and variational two-electron reduced-density matrix methods.

J Chem Theory Comput 2018 Dec 17. Epub 2018 Dec 17.

Complete active space self-consistent field (CASSCF) computations can be realized at polynomial cost via the variational optimization of the active-space two-electron reduced-density matrix (2-RDM). Like conventional approaches to CASSCF, variational 2-RDM (v2RDM)-driven CASSCF captures nondynamical electron correlation in the active space, but it lacks a description of the remaining dynamical correlation effects. Such effects can be modeled through a combination of v2RDM-CASSCF and on-top pair-density functional theory (PDFT). Read More

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December 2018

An Integrated Pipeline of Isotopic Labeling and Selective Enriching for Quantitative Analysis of N-Glycome by Mass Spectrometry.

Anal Chem 2018 Dec 17. Epub 2018 Dec 17.

Quantitative N-glycomics can reveal abnormal expression of N-glycan in diseases. However, mass spectrometry (MS)-based N-glycome quantitative analysis is still technically challenging. To achieve the quantitation of N-glycome with high accuracy and sensitivity, it is required to efficiently label the N-glycans with isotopic tags and selectively enrich N-glycans to avoid suppression from other substances. Read More

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December 2018
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