1,068,812 results match your criteria Applied Psychology-an International Review-psychologie Appliquee-revue Internationale[Journal]


Verification of Nuclear Magnetic Resonance Characterization of Traditional Homeopathically Manufactured Metal (Cuprum metallicum) and Plant (Gelsemium sempervirens) Medicines and Controls.

Homeopathy 2020 Jul 2. Epub 2020 Jul 2.

Unio Homoeopathica Belgica, Evergem, Belgium.

Background:  Nuclear magnetic resonance (NMR) proton relaxation is sensitive to the dynamics of the water molecule, HO, through the interaction of the spin of the proton (H) with external magnetic and electromagnetic fields. NMR relaxation times describe how quickly the spin of H, forced in a direction by an external electromagnetic field, returns to a normal resting position. As a result, such measurements allow us potentially to describe higher structuring of water in homeopathic medicines. Read More

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http://dx.doi.org/10.1055/s-0040-1710022DOI Listing

Emerging Immunotherapies for Malignant Glioma: From Immunogenomics to Cell Therapy.

Neuro Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

As immunotherapy assumes a central role in the management of many cancers, ongoing work is directed at understanding whether immune-based treatments will be successful in patients with glioblastoma (GBM). Despite several large studies conducted in the last several years, there remain no FDA approved immunotherapies in this patient population. Nevertheless, there are a range of exciting new approaches being applied to GBM, all of which may not only allow us to develop new treatments but also help us understand fundamental features of the immune response in the central nervous system. Read More

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http://dx.doi.org/10.1093/neuonc/noaa154DOI Listing

Artificial Intelligence and Hypertension: Recent Advances and Future Outlook.

Am J Hypertens 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Prevention and treatment of hypertension (HTN) is a challenging public health problem. Recent evidence suggests that artificial intelligence (AI) has potential to be a promising tool for reducing the global burden of HTN, and furthering precision medicine related to cardiovascular (CV) diseases including HTN. Since AI can stimulate human thought processes and learning with complex algorithms and advanced computational power, AI can be applied to multimodal and big data, including genetics, epigenetics, proteomics, metabolomics, CV imaging, socioeconomic, behavioral and environmental factors. Read More

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http://dx.doi.org/10.1093/ajh/hpaa102DOI Listing

LC-MS/MS method for quantitation of the CK2 inhibitor silmitasertib (CX-4945) in human plasma, CSF, and brain tissue, and application to a clinical pharmacokinetic study in children with brain tumors.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 23;1152:122254. Epub 2020 Jun 23.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

Silmitasertib (CX-4945) as a potent and selective inhibitor of CK2 exhibited promising in vitro and in vivo anti-cancer activity. An assay employing cation-exchange solid phase extraction (SPE) followed by LC-MS/MS analysis was successfully developed and validated for the quantitation of silmitasertib in human plasma, brain tissue, and human cerebrospinal fluid (CSF). Reverse phase chromatographic separation was achieved using Synergi™ hydro-RP column (4 μm, 75 × 2. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122254DOI Listing

Metallothionein isoforms as double agents - Their roles in carcinogenesis, cancer progression and chemoresistance.

Drug Resist Updat 2020 Mar 4;52:100691. Epub 2020 Mar 4.

Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic; Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic. Electronic address:

Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms identified in mammals, designated MT-1 through MT-4. The best known biological functions of MTs are their ability to bind and sequester metal ions as well as their active role in redox homeostasis. Despite these protective roles, numerous studies have demonstrated that changes in MT expression could be associated with the process of carcinogenesis and participation in cell differentiation, proliferation, migration, and angiogenesis. Read More

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http://dx.doi.org/10.1016/j.drup.2020.100691DOI Listing

c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism.

Colloids Surf B Biointerfaces 2020 Jun 25;194:111211. Epub 2020 Jun 25.

Department of Applied Physiology, School of Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan.

Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111211DOI Listing

Novel fluorescence probe based on bright emitted carbon dots for ClO detection in real water samples and living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 13;240:118592. Epub 2020 Jun 13.

Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen 518060, PR China.

Low-toxic and environmentally friendly carbon dots (CDs) have been extensively applied in various fields. CDs usually demonstrate excellent selectivity and high sensitivity, especially in ion detection. However, the most commonly used CDs are excited by ultraviolet (UV) light and emit weak fluorescence light, limiting their application in some fields. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118592DOI Listing

Purification of the leaching solution of recycling zinc from the hazardous electric arc furnace dust through an as-bearing jarosite.

Ecotoxicol Environ Saf 2020 Jun 29;202:110893. Epub 2020 Jun 29.

School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box 11155/4563, Tehran, Iran.

Leaching of the hazardous electric arc furnace (EAF) dust containing mainly zinc ferrite and zinc oxide, accompanied by minor concentrations of arsenic compounds, was investigated using sulfuric acid. In order to reach the maximum recovery of zinc, the leaching solution was adjusted to recover both iron and zinc at their maximum possible values. To obtain a high recovery value of zinc and iron, analyzed by AAS, the optimum leaching condition was found to be the temperature of 90 °C, the sulfuric acid concentration of 3 M, the particle size of 75 μm, the S/L ratio of 1:10 g/mL and the leaching time of 2 h. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110893DOI Listing

Deep learning-based pulmonary nodule detection: Effect of slab thickness in maximum intensity projections at the nodule candidate detection stage.

Comput Methods Programs Biomed 2020 Jun 20;196:105620. Epub 2020 Jun 20.

Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background And Objective: To investigate the effect of the slab thickness in maximum intensity projections (MIPs) on the candidate detection performance of a deep learning-based computer-aided detection (DL-CAD) system for pulmonary nodule detection in CT scans.

Methods: The public LUNA16 dataset includes 888 CT scans with 1186 nodules annotated by four radiologists. From those scans, MIP images were reconstructed with slab thicknesses of 5 to 50 mm (at 5 mm intervals) and 3 to 13 mm (at 2 mm intervals). Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105620DOI Listing

Re-entrant swelling and redissolution of polyelectrolytes arises from an increased electrostatic decay length at high salt concentrations.

J Colloid Interface Sci 2020 Jun 20;579:369-378. Epub 2020 Jun 20.

Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, PR China; Department of Applied Mathematics, Research School of Physics and Engineering, The Australian National University, Canberra, ACT 2601, Australia. Electronic address:

Hypothesis: A detailed understanding of the influence of electrolytes on the conformation of polyelectrolyte chains is an important goal made challenging by the strong coupling between electrostatic interactions and chain conformation. This challenge is particularly evident at moderate to high salt concentrations where mean-field theories of electrolytes are no longer applicable and are therefore unable to predict the interactions between neutral or like charged surfaces that leads to re-entrant swelling of DNA and other polyelectrolytes at high salt concentrations. Recent developments arising from studies of surface forces in ionic liquids that have been extended to include a wide variety of monovalent electrolytes reveal a hitherto unknown increase in the electrostatic decay length at high electrolyte concentrations. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.072DOI Listing

Physiological and metabolic responses to hypersalinity reveal interpopulation tolerance in the green macroalga Ulva compressa with different pollution histories.

Aquat Toxicol 2020 Jun 25;225:105552. Epub 2020 Jun 25.

Laboratory of Aquatic Environmental Research, Centro de Estudios Avanzados, Universidad de Playa Ancha, Viña del Mar, Chile; ENVIRONMENTAL HUB UPLA, Universidad de Playa Ancha, Valparaíso, Chile. Electronic address:

There is scarce investigation addressing interpopulation tolerance responses to address the influence of a history of chronic stress exposure, as that occurring in polluted environments, in photoautotrophs. We evaluated ecophysiological (photosynthetic activity) and metabolic (oxidative stress and damage) responses of two populations of green macroalga Ulva compressa from polluted (Ventanas) and non-polluted (Cachagua) localions of central Chile, and exposed to controlled hypersalinity conditions of 32 (control), 42, 62 and 82 psu (practical salinity units) for 6 h, 48 h and 6 d. Both primary production (ETR) and photosynthetic efficiency (α) were generally higher in the population from Cachagua compared to Ventanas at all times and salinities. Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105552DOI Listing

Tumor Microenvironment-Activated Degradable Multifunctional Nanoreactor for Synergistic Cancer Therapy and Glucose SERS Feedback.

iScience 2020 Jun 16;23(7):101274. Epub 2020 Jun 16.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China; University of Science and Technology of China, Hefei 230026, P. R. China. Electronic address:

Integration of disease diagnosis and therapy in vivo by nanotechnology is a challenge in the design of multifunctional nanocarriers. Herein, we report an intelligent and degradable nanoreactor, an assembly of the 4-mercaptobenzonitrile-decorated silver nanoparticles (AgNPs@MBN) and the glucose oxidase (GOx)-loaded metal-organic-framework (ZIF-8@GOx), which can be activated by tumor microenvironment to start the catalytic cascade-enhanced chemo-starvation synergistic therapy and simultaneous self-sense of cellular glucose level. Under the mild acidic microenvironment of tumor, the nanoreactor will collapse to release GOx that triggers a catalytic cascade reaction in vivo, depleting glucose, etching AgNPs@MBN, and producing toxic HO, Ag, and Zn ions, all of which work together to inhibit tumor growth. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101274DOI Listing

Impact of pyrochar and hydrochar derived from digestate on the co-digestion of sewage sludge and swine manure.

Bioresour Technol 2020 Jun 24;314:123730. Epub 2020 Jun 24.

Institute of Bioresource and Agriculture and Sino-Forest Applied Research Centre for Pearl River Delta Environment, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Department of Biology, Hong Kong Baptist University, Hong Kong Special Administrative Region. Electronic address:

Four kinds of biochar were obtained by pyrolysis carbonization and hydrothermal carbonization from swine manure digestate, i.e. pyrochar (HC, HC-Fe) and hydrochar (HTC, HTC-Fe). Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123730DOI Listing

Astaxanthin biosynthesis promotion with pH shock in the green microalga, Haematococcus lacustris.

Bioresour Technol 2020 Jun 26;314:123725. Epub 2020 Jun 26.

Division of Environmental Science & Ecological Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address:

In this study, the use of pH shock to improve astaxanthin synthesis in Haematococcus lacustris was investigated. It has been found that pH shock (pH = 4.5, 60 s) imposes stress in the cells and induces physiological changes, which result in astaxanthin accumulation. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123725DOI Listing

Evaluation of the SNAP® 4Dx® plus test for the detection of Dirofilaria immitis antigen and characterization of exposure to tick-borne pathogens in wild canids in southern Ontario.

Vet Parasitol 2020 Jun 25;283:109176. Epub 2020 Jun 25.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Population-level surveys for Dirofilaria immitis in wild canids typically rely on identification of the parasite at necropsy. More recently, some studies have employed the use of the SNAP® 4Dx® Plus test. However, since the assay was designed for use with domestic dogs it needs to be validated for use with wild canids for accurate interpretation of results. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109176DOI Listing

A green and efficient vortex-assisted liquid-phase microextraction based on supramolecular solvent for UV-VIS determination of nitrite in processed meat and chicken products.

Food Chem 2020 Jun 23;332:127395. Epub 2020 Jun 23.

Sivas Cumhuriyet University, Faculty of Sciences, Department of Chemistry, TR-58140 Sivas, Turkey.

This paper describes a simple, efficient and rapid analytical method for extraction and determination of nitrite in meat and chicken products by vortex-assisted supramolecular solvent-based liquid phase microextraction (VA-SUPRAS-LPME) prior to spectrophotometric detection. The SUPRAS was rapidly formed by the addition of a colloidal decanoic acid suspension to tetrahydrofuran (THF). The validation studies were carried out in terms of linearity, limit of detection (LOD), limit of quantitation (LOQ), matrix effects, robustness, uncertainty measurement, precision, accuracy, and certified reference material (CRM) analysis using optimized experimental conditions. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127395DOI Listing

Monitoring of soluble pectin content in orange juice by means of MIR and TD-NMR spectroscopy combined with machine learning.

Food Chem 2020 Jun 23;332:127383. Epub 2020 Jun 23.

Embrapa Instrumentation, Rua XV de Novembro 1452, São Carlos, SP 13561-206, Brazil. Electronic address:

This study represents a rapid and non-destructive approach based on mid-infrared (MIR) spectroscopy, time domain nuclear magnetic resonance (TD-NMR), and machine learning classification models (ML) for monitoring soluble pectin content (SPC) changes in orange juice. Current reference methods of SPC in orange juice are laborious, requiring several extractions with successive adjustments hindering rapid process intervention. 109 fresh orange juices samples, representing different harvests, were analysed using MIR, TD-NMR and reference method. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127383DOI Listing

One step synthesis of red-emitting fluorescence turn-on probe for nitroreductase and its application to bacterial detection and oral cancer cell imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 23;241:118637. Epub 2020 Jun 23.

Hospital of Stomatology, Jilin University, Qinghua Road 1500, Changchun 130021, China. Electronic address:

Nitroreductase (NTR) belongs to a class of flavin mononucleotide-dependent and flavin adenine dinucleotide-dependent cytoplasmic enzymes; its contents in tumor cells increase during hypoxia. The development of fluorescent probes for detection of NTR activity is of great significance for the study of the state of hypoxia in living organisms. In this paper, a red-emitting fluorescence turn-on probe EBI-NO was synthesized using a one-step method. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118637DOI Listing

An improved analytical model of the magnetostriction-based EMAT of SH mode guided wave in a ferromagnetic plate.

Ultrasonics 2020 Jun 26;108:106213. Epub 2020 Jun 26.

Institute of Fluid Science, Tohoku University, Sendai 980-8577, Japan.

The accuracy of electro-acoustic energy transfer efficiency (EAETE) model directly determines the optimization results of an electromagnetic acoustic transducer (EMAT). In this study, the EMAT model of SH mode generation based on magnetostriction mechanism is re-examined. In the existing magnetostriction-based EMAT (MEMAT) analytical model, an approximate method of dynamic magnetic field was employed. Read More

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http://dx.doi.org/10.1016/j.ultras.2020.106213DOI Listing

Model averaging methods for the evaluation of dose-response model uncertainty when assessing the suitability of studies for estimating risk.

Environ Int 2020 Jun 29;143:105857. Epub 2020 Jun 29.

CPHEA U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

This paper describes the use of multiple models and model averaging for considering dose-response uncertainties when extrapolating low-dose risk from studies of populations with high levels of exposure. The model averaging approach we applied builds upon innovative methods developed by the U.S. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105857DOI Listing

Discrimination of Mentha species grown in different geographical areas of Algeria using H-NMR-based metabolomics.

J Pharm Biomed Anal 2020 Jun 24;189:113430. Epub 2020 Jun 24.

Unit of Therapeutic Chemistry and Pharmacognosy, Université de Mons (UMONS), Mons, Belgium; Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Université Libre de Bruxelles (ULB), Belgium.

H-NMR-based metabolomics have been applied to identify potential NMR-markers and biomarkers capable of distinguishing, qualifying and classifying three Mentha species:- Mentha pulegium L., Mentha × rotundifolia (L.) Huds. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113430DOI Listing

Changes in resting-state brain connectivity following computerized cognitive behavioral therapy for insomnia in dialysis patients: A pilot study.

Gen Hosp Psychiatry 2020 Jun 3;66:24-29. Epub 2020 Jun 3.

Department of Internal Medicine and Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Insomnia is prevalent among dialysis patients and affects their mortality. Although cognitive behavioral therapy for insomnia (CBTi) is recommended, attending regular face-to-face CBTi sessions is a major challenge for patients. We evaluated the effectiveness of a self-directed computerized CBTi (cCBTi) in dialysis patients, and investigated changes in resting-state brain connectivity and inflammatory cytokines following cCBTi. Read More

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http://dx.doi.org/10.1016/j.genhosppsych.2020.05.013DOI Listing

Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents.

Neuroimage 2020 Jun 29:117105. Epub 2020 Jun 29.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. Electronic address:

The ability to effectively suppress motor response tendencies is essential for focused and goal-directed behavior. Here, we tested the hypothesis that developmental improvement in the ability to cancel a motor response is reflected by maturational changes in the white matter underlying the right presupplementary motor area (preSMA) and posterior inferior frontal gyrus (IFG), two cortical key areas of the fronto-basal ganglia "stopping" network. Eighty-eight typically-developing children and adolescents, aged 7-19 years, were longitudinally assessed with the stop-signal task (SST) and diffusion tensor imaging (DTI) of the brain over a period of six years. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.117105DOI Listing

Progressive effects of sildenafil on visual processing in rats.

Neuroscience 2020 Jun 29. Epub 2020 Jun 29.

Translational Biology, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark.

Photoreceptors are light-sensitive cells in the retina converting visual stimuli into electrochemical signals. These signals are evaluated and interpreted in the visual pathway, a process referred to as visual processing. Phosphodiesterase type 5 and 6 (PDE5 and 6) are abundant enzymes in retinal vessels and notably photoreceptors where PDE6 is exclusively present. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.06.033DOI Listing

Production of a codonopsis polysaccharide iron complex and evaluation of its properties.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

College of Veterinary medicine, Qingdao Agricultural University, Qingdao, People's Republic of China; Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, People's Republic of China. Electronic address:

A water extraction and alcohol precipitation method was applied to extract polysaccharides from Codonopsis pilosula (CPP), response surface methodology was used to optimize the extraction conditions and synthesis of C. pilosula polysaccharide iron (CPPI), and the properties of CPPI were evaluated. The optimum extraction conditions for CPP were as follows: liquid-solid ratio of 29. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.210DOI Listing

Extraction, purification and antioxidant activity of polysaccharide from cold pressed oil cake of 'Tengjiao' seed.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

College of Food Science, Sichuan Agricultural University, 46 Xinkang Road, Yaan 625014, China. Electronic address:

Tengjiao (Zanthoxylum armatum DC.) seed cold pressed oil cake (CPC), the main by-product of the cold-pressed oil process, is mainly used for animal feed or crop fertilizer, resulting in a great waste of resources. To improve the added value, the CPC polysaccharide (CPCP) was extracted and purified, and its antioxidant activity was studied. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.207DOI Listing

Characteristics of alkali-extracted peanut polysaccharide-protein complexes and their ability as Pickering emulsifiers.

Int J Biol Macromol 2020 Jun 29. Epub 2020 Jun 29.

State Key Laboratory of Food Science & Technology, School of Food Science and Technology, Jiangnan University, 214122 Wuxi, China. Electronic address:

An alkaline isolation method was applied to extract polysaccharide from residues of peanut oil processing while retaining high protein content, in order to enhance the emulsifying ability of these materials. The obtained complexes (PECs) containing protein (13-18%, dry basis) were named as PEC8.0, PEC10. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.245DOI Listing

The effect of access cavities and canal enlargement on biomechanics of endodontically treated teeth: a finite element analysis.

J Endod 2020 Jun 29. Epub 2020 Jun 29.

Department of Stomatology, Xiangya Hospital, Central South University, 87# Xiangya Road, Changsha, Hunan, China. Electronic address:

Introduction: The purpose of this study was to investigate the influence of access cavities and tapers of canal preparations on fracture resistance of endodontically treated first molar by finite element method (FEM) and Weibull ananlysis.

Methods: Based on the micro-computed tomographic data of maxillary first molar, the models of endodontically treated teeth with conservative endodontic cavity (CEC), traditional endodontic cavity (TEC) and 4 tapers of canal preparations (0.02, 0. Read More

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http://dx.doi.org/10.1016/j.joen.2020.06.013DOI Listing

Fish reproductive biology - reflecting on five decades of fundamental and translational research.

Authors:
Yonathan Zohar

Gen Comp Endocrinol 2020 Jun 29:113544. Epub 2020 Jun 29.

Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland, Baltimore County, Baltimore, Maryland, 21202, United States.

Driven by the broad diversity of species and physiologies and by reproduction-related bottlenecks in aquaculture, the field of fish reproductive biology has rapidly grown over the last five decades. This review provides my perspective on the field during this period, integrating fundamental and applied developments and milestones. Our basic understanding of the brain-pituitary-gonadal axis led to overcoming the failure of farmed fish to ovulate and spawn in captivity, allowing us to close the fish life cycle and establish a predictable, year-round production of eggs. Read More

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http://dx.doi.org/10.1016/j.ygcen.2020.113544DOI Listing

Liver transplantation in hepatocellular carcinoma after tumour downstaging (XXL): a randomised, controlled, phase 2b/3 trial.

Lancet Oncol 2020 Jul;21(7):947-956

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; HPB Surgery, Hepatology and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.

Background: Indications for liver transplantation for hepatocellular carcinoma are evolving and so-called expanded criteria remain debated. Locoregional therapies are able to downstage hepatocellular carcinoma from beyond to within the Milan criteria. We aimed to investigate the efficacy of liver transplantation after successful hepatocellular carcinoma downstaging. Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30224-2DOI Listing

Sternal Resection and Reconstruction with a Novel Modularized Prosthesis.

Ann Thorac Surg 2020 Jun 29. Epub 2020 Jun 29.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, School of Medicine. 507 Zhengmin Road, Shanghai 200433, China. Electronic address:

Purpose: Currently available techniques and materials for sternal reconstruction are limited in their clinical applicability. We aimed to design a durable prosthetic kit that can be tailored to each patient's sternal anatomy and function intra-operatively.

Description: A modularized sternal reconstruction system was designed, containing standardized components of different types and sizes, made of titanium alloy. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.05.048DOI Listing

Treatments of trimethylaminuria: where we are and where we might be heading.

Drug Discov Today 2020 Jun 29. Epub 2020 Jun 29.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland. Electronic address:

Trimethylamine (TMA) is a volatile, foul-smelling, diet-derived amine, primarily generated in the colon and metabolized in the liver to its odorless N-oxide (TMAO). In primary trimethylaminuria (TMAU), an inherited deficiency in flavin-containing monooxygenase 3 leads to elevated systemic TMA levels. The excretion of elevated amounts of TMA in sweat, breath, urine and other bodily secretions gives individuals affected by TMAU a smell resembling that of rotten fish. Read More

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http://dx.doi.org/10.1016/j.drudis.2020.06.026DOI Listing

The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.

RNA Biol 2020 Jul 2. Epub 2020 Jul 2.

Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore (UOL) , Lahore, Pakistan.

Circular RNAs (circRNAs) are ubiquitously expressed, covalently closed rings, produced by pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity endows 3'-5'-linked circRNAs with stability and resistance to exonucleolytic degradation which raises the question whether circRNAs may be relevant as potential therapeutic targets or agents. High stability in biological systems is the most remarkable property and a major criterion for why circRNAs could be exploited for a range of RNA-centered medical applications. Read More

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http://dx.doi.org/10.1080/15476286.2020.1790198DOI Listing

Long noncoding RNA is highly expressed in colorectal cancer and predicts a poor prognosis.

Future Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, PR China.

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. This study aimed to investigate the role of long noncoding RNA in CRC. The expression of in 103 cases of CRC tissues and four CRC cell lines was examined by quantitative real-time PCR. Read More

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http://dx.doi.org/10.2217/fon-2020-0393DOI Listing

Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min.

Anal Chem 2020 Jul 2. Epub 2020 Jul 2.

The outbreak of SARS-CoV-2 is posing serious global public health problems. Facing the emergence of this pandemic, we established a portable microfluidic immunoassay system for easy-to-use, sensitive, rapid (<15 min), multiple and on-site detection of IgG/IgM/Antigen of SARS-CoV-2 simultaneously. This integrated method was successfully applied for detecting SARS-CoV-2 IgM and IgG antibodies in clinical human serum as well as SARS-CoV-2 antigen in pharyngeal swab from 26 patients with COVID-19 infection and 28 uninfected people. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01635DOI Listing

A CRISPR-Cas9 tool to explore the genetics of Bacillus subtilis phages.

Lett Appl Microbiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Genomic and Applied Microbiology and Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Göttingen, 37077, Göttingen, Germany.

Here we present pRH030, a new CRISPR-Cas9 tool for the genetic engineering of Bacillus phages and beyond. It is based on the Streptococcus pyogenes cas9 with its native constitutive promoter, tracrRNA, and a gRNA precursor. The constitutive expression of Cas9 was conducive to the inactivation of viral attackers and enhanced phage mutagenesis efficiency up to 100%. Read More

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http://dx.doi.org/10.1111/lam.13349DOI Listing

Associations between Osteoporosis and risk of Periodontitis: A Pooled Analysis of Observational Studies.

Oral Dis 2020 Jul 2. Epub 2020 Jul 2.

Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Background: Periodontitis and osteoporosis are most popular among aging population and both conditions might be linked, even though, this suggestion still until now debated.

Objectives: A meta-analysis on previous investigations has been used to evaluate the correlation between periodontitis and osteoporosis to determine whether osteoporosis is a local indicator of bone loss, or whether it is depending on or related to periodontitis causes.

Methods: The literature database, including but not excluding, The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and Science Citation Index Expanded, were searched in this work during Feb, 2020. Read More

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http://dx.doi.org/10.1111/odi.13531DOI Listing

Innovative Approach to Aesthetical Medicine Services Quality Assessment.

J Cosmet Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical and Preventive Technologies for Public Health Risk Management Nizhny Novgorod Research, Institute of Hygiene and Occupational Pathology of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, 20 Semashko Str., Nizhny Novgorod, 603105, Russian Federation.

Recently, both doctors and patients, pay particular attention to aesthetic medical services quality as well as efficacy of aesthetic adjustment implemented. It is essential to ensure research, analysis and improving of botulinum toxin therapy quality, and provide patients' orientation on the adjustment schedule, which includes long-term observation period, in order to accomplish the expected goals and increase degree of satisfaction. Injections of medication like botulinum A toxin are highly-demanded in many types of aesthetic treatment. Read More

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http://dx.doi.org/10.1111/jocd.13584DOI Listing

Obstetric hemorrhage in resource-limited locations: A quality improvement project after adoption of abdominopelvic compression devices.

Int J Gynaecol Obstet 2020 Jul 2. Epub 2020 Jul 2.

Department of Surgery, Porgera District Hospital, Enga Province, Papua New Guinea.

Objective: To evaluate obstetric hemorrhage outcomes and present data specific to adoption of pneumatic circumferential abdominopelvic compression devices.

Methods: Two resource-limited locations added low-cost pneumatic compression devices to their standard protocols for obstetric hemorrhage between 2010 and 2019. Providers in rural Nepal and Papua New Guinea used devices that incorporated a bicycle tube or soccer ball ("Ball and Binder") to provide abdominopelvic pressure after all available routine treatments had failed. Read More

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http://dx.doi.org/10.1002/ijgo.13291DOI Listing

A rapid UHPLC-MS/MS method for the quantification of ARQ531 in rat plasma: validation and its application to a pharmacokinetic study.

Biomed Chromatogr 2020 Jul 2:e4937. Epub 2020 Jul 2.

Laboratory of Animal Center, Guangdong Medical University, Dongguan, China.

A simple and sensitive ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS) method was developed and validated for the determination of ARQ531, a BTK inhibitor in rat plasma. After protein precipitation with acetonitrile, the samples were separated on a UPLC BEH C column with 0.1% formic acid in water and acetonitrile as mobile phase at a flow rate of 0. Read More

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http://dx.doi.org/10.1002/bmc.4937DOI Listing

The Effect of Hallux Valgus Surgery on Quality of Life.

J Am Podiatr Med Assoc 2020 Jul 2. Epub 2020 Jul 2.

†Department of Orthopaedics and Traumatology, Ufuk University Faculty of Medicine, Ankara, Turkey.

Background: Health-related quality of life (QOL) is defined as a patient's subjective perception of his or her own health. There is not enough data on QOL of the patients who undergo a hallux valgus (HV) operation. We used a 36-item short form survey (SF-36) to measure QOL of such patients. Read More

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http://dx.doi.org/10.7547/19-001DOI Listing

Reliable and Sensitive Detection of Glycosaminoglycan Chains with Immunoblots.

Glycobiology 2020 Jul 2. Epub 2020 Jul 2.

Laboratory of Developmental Neurobiology, Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Complex glycans play vital roles in many biological processes, ranging from intracellular signaling and organ development to tumor growth. Glycan expression is routinely assessed by the application of glycan-specific antibodies to cells and tissues. However, glycan-specific antibodies quite often show a large number of bands on immunoblots and it is hard to interpret the data when reliable controls are lacking. Read More

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http://dx.doi.org/10.1093/glycob/cwaa060DOI Listing

Detecting rare diseases in electronic health records using machine learning and knowledge engineering: Case study of acute hepatic porphyria.

PLoS One 2020 2;15(7):e0235574. Epub 2020 Jul 2.

Department of Medical Informatics & Clinical Epidemiology, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States of America.

Background: With the growing adoption of the electronic health record (EHR) worldwide over the last decade, new opportunities exist for leveraging EHR data for detection of rare diseases. Rare diseases are often not diagnosed or delayed in diagnosis by clinicians who encounter them infrequently. One such rare disease that may be amenable to EHR-based detection is acute hepatic porphyria (AHP). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235574PLOS

Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.

PLoS One 2020 2;15(7):e0235641. Epub 2020 Jul 2.

Joint Institute for Food Safety and Applied Nutrition, Center for Food Safety and Security Systems, University of Maryland, College Park, Maryland, United States of Amrica.

We sequenced 25 isolates of phenotypically multidrug-resistant Salmonella Indiana (n = 11), Typhimurium (n = 8), and Enteritidis (n = 6) using both MinION long-read [SQK-LSK109 and flow cell (R9.4.1)] and MiSeq short-read (Nextera XT and MiSeq Reagent Kit v2) sequencing technologies to determine the advantages of each approach in terms of the characteristics of genome structure, antimicrobial resistance (AMR), virulence potential, whole-genome phylogeny, and pan-genome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235641PLOS

Assessing the costs and returns of on-farm food safety improvements: A survey of Good Agricultural Practices (GAPs) training participants.

PLoS One 2020 2;15(7):e0235507. Epub 2020 Jul 2.

Produce Safety Alliance, Cornell University, Geneva, NY, United States of America.

Good Agricultural Practices (GAPs) training programs were developed to provide guidance to fruit and vegetable growers on how to reduce food safety risks on the farm. These programs have been enhanced over the years due, in part, to increasing buyer and regulatory requirements. However, the costs of implementing additional food safety practices has been identified as a primary barrier to long-term farm financial feasibility, particularly for smaller scale producers. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235507PLOS

Using social choice theory and acceptability analysis to measure the value of health systems.

PLoS One 2020 2;15(7):e0235531. Epub 2020 Jul 2.

Department of Industrial & Manufacturing Systems Engineering, The University of Hong Kong, Hong Kong SAR.

The Future Health Index (FHI) is developed by the Royal Philips to help determine the readiness of countries to address global health challenges and build sustainable, fit-for-purpose national health systems. The FHI 2018 presents the Value Measure to measure the value of 16 health systems, which is formulated by taking the arithmetic average of Access, Satisfaction and Efficiency. However, this scheme is not the Pareto optimal and loses association with weights. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235531PLOS

Changes in gene expression in potato meristems treated with the sprout suppressor 1,4-dimethylnaphthalene are dependent on tuber age and dormancy status.

PLoS One 2020 2;15(7):e0235444. Epub 2020 Jul 2.

School of Science, Penn State Erie, The Behrend College,Erie, PA, United States of America.

Commercial storage of potatoes often relies on the use of sprout inhibitors to prolong storage and reduce spoilage. The compound 1,4-dimethylnaphthalene (DMN) has seen increase application as a sprout inhibitor in the potato industry as older chemistries are being phased out. The mode of action of DMN is poorly understood as is the sensitivity of potato tissues to this new class of inhibitor. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235444PLOS

Raman Spectroscopy characterization extracellular vesicles from bovine placenta and peripheral blood mononuclear cells.

PLoS One 2020 2;15(7):e0235214. Epub 2020 Jul 2.

Department of Biological Engineering, Utah State University, Logan, Utah, United States of America.

Placenta-derived extracellular vesicles (EVs) are involved in communication between the placenta and maternal immune cells possibly leading to a modulation of maternal T-cell signaling components. The ability to identify EVs in maternal blood may lead to the development of diagnostic and treatment tools for pregnancy complications. The objective of this work was to differentiate EVs from bovine placenta (trophoblast) and peripheral blood mononuclear cells (PBMC) by a label-free, non-invasive Raman spectroscopy technique. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235214PLOS

Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR.

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0008296. Epub 2020 Jul 2.

Department of Virology, Parasitology and Immunology, Ghent University, Merelbeke, Belgium.

World Health Organization (WHO) has defined moderate-to-heavy intensity (M&HI) infections with soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichiura and the two hookworms, Ancylostoma duodenale and Necator americanus) based on specific values of eggs per gram of stool, as measured by the Kato-Katz method. There are a variety of novel microscopy and DNA-based methods but it remains unclear whether applying current WHO thresholds on to these methods allows for a reliable classification of M&HI infections. We evaluated both WHO and method-specific thresholds for classifying the M&HI infections for novel microscopic (FECPAKG2, McMaster and Mini-FLOTAC) and DNA-based (qPCR) diagnostic methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008296DOI Listing
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