957,782 results match your criteria Applied Physics Express[Journal]


A study of the mechanical properties of as-received and intraorally exposed single-crystal and polycrystalline orthodontic ceramic brackets.

Eur J Orthod 2019 Apr 23. Epub 2019 Apr 23.

Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Switzerland.

Background: Although ceramic brackets have been extensively used for decades in orthodontics there is not till today any study focusing on the possible deterioration of mechanical properties after in vivo ageing.

Objectives: To determine whether the mechanical properties of alumina orthodontic brackets change after intraoral ageing thereby assessing the validity of a theoretical model established for the performance of ceramics in wet environments.

Materials And Methods: Two alumina brackets, one single crystal (Radiance, American Orthodontics, Sheboygan, WI) and one polycrystalline (Clarity, 3M, St. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ejo/cjz024DOI Listing

Induction of apoptosis in CD4(+) T-cells is linked with optimal treatment response in patients with relapsing-remitting multiple sclerosis treated with Glatiramer acetate.

J Neurol Sci 2019 Mar 29;401:43-50. Epub 2019 Mar 29.

Multiple Sclerosis Center, B' Neurological University Department, AHEPA General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address:

Background: Induction of T-cell apoptosis constitutes a mechanism of action for Glatiramer Acetate (GA). We investigated whether activation of apoptotic T-cell death may be indicative of optimal treatment response in patients with relapsing-remitting Multiple Sclerosis (RRMS), with respect to radiological activity.

Methods: We studied apoptotic markers on blood T-cells of forty patients with RRMS, 19 patients under GA and 21 patients under interferon-β (IFNβ), by flow cytometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.03.030DOI Listing

Patch-based lung ventilation estimation using multi-layer supervoxels.

Comput Med Imaging Graph 2019 Apr 5;74:49-60. Epub 2019 Apr 5.

Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, UK.

Patch-based approaches have received substantial attention over the recent years in medical imaging. One of their potential applications may be to provide more anatomically consistent ventilation maps estimated on dynamic lung CT. An assessment of regional lung function may act as a guide for radiotherapy, ensuring a more accurate treatment plan. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08956111183018
Publisher Site
http://dx.doi.org/10.1016/j.compmedimag.2019.04.002DOI Listing
April 2019
1 Read

Improved electrocatalytic activity of Au@FeO magnetic nanoparticles for sensitive dopamine detection.

Colloids Surf B Biointerfaces 2019 Apr 16;180:1-8. Epub 2019 Apr 16.

Electroorganic Division, CSIR-Central Electrochemical Research Institute, Karaikudi 630003, India. Electronic address:

Substantially, noble metals are important for the development of low-cost, sensitive, selective, superior performance, and portable electrochemical sensors. Herein, we describe gold (Au) nanoparticles (NPs) systematically decorated with magnetic FeO nanocomposites on the fabrication of sensitive dopamine sensor is described. Magnetic Au@FeO nanocomposites were prepared by reducing HAuCl on the surfaces of FeO nanoparticles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2019.04.034DOI Listing

A pilot study on the efficacy of transcranial direct current stimulation applied to the pharyngeal motor cortex for dysphagia associated with brainstem involvement in multiple sclerosis.

Clin Neurophysiol 2019 Apr 11;130(6):1017-1024. Epub 2019 Apr 11.

Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Via Atinense 18, 86077 Pozzilli, IS, Italy.

Objective: we investigated the effect of anodal transcranial direct current stimulation (tDCS) applied over the pharyngeal motor area in dysphagia associated with multiple sclerosis (MS).

Methods: Eighteen MS patients with dysphagia associated with brainstem involvement were randomized to receive either "real" or "sham" tDCS.

Primary Outcome: The Penetration/Aspiration Scale (PAS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2019.04.003DOI Listing

Mechanical modeling of pimple growth.

J Mech Behav Biomed Mater 2019 Apr 16;95:191-195. Epub 2019 Apr 16.

Advanced Materials for Energy and Environment, Department of Earth and Environmental Engineering, Columbia University, New York, NY, 10027, USA; School of Chemical Engineering, Northwest University, Xi'an, 710069, PR China.

Pimple is one of the most common skin diseases for humans, whose growth cause pain yet the corresponding mechanical analysis is lacking. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the mechanical stimulus is related to the sensation of pain during the development of pimple. Parametric studies show the dependence of mechanical stimulus and pain level on the pimple-surrounded structures, follicle depth and mechanical properties of the epidermis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmbbm.2019.04.017DOI Listing

Load-bearing capacities of ultra-thin occlusal veneers bonded to dentin.

J Mech Behav Biomed Mater 2019 Apr 13;95:165-171. Epub 2019 Apr 13.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Switzerland. Electronic address:

Objectives: To test whether the load-bearing capacity of occlusal veneers made of ceramic or hybrid materials bonded to dentin does differ from those of porcelain-fused-to metal or lithium disilicate glass ceramic crowns.

Material And Methods: In 80 human molars, occlusal tooth substance was removed so that the defects extended into dentin, simulating defects caused by attrition/erosion. Restorations at a standardized thickness of either 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmbbm.2019.04.006DOI Listing

Facile conversion of kaolinite into clay nanotubes (KNTs) of enhanced adsorption properties for toxic heavy metals (Zn, Cd, Pb, and Cr) from water.

J Hazard Mater 2019 Apr 15;374:296-308. Epub 2019 Apr 15.

Botany & Microbiology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Kaolinite nanotubes (KNTs) were synthesized from kaolinite by ultrasonic scrolling and characterized using X-ray diffractometer, scanning and transmission electron microscopes; and FTIR-FT Raman spectrometer. The synthetic KNTs appear as multi-walled scrolls of 12 nm average pore diameter and 50-600 nm particle length; and exhibit surface area of 105 m/g. KNTs were used as adsorbents for Zn, Cd, Pb, and Cr with uptake capacities of 103 mg/g, 116 mg/g, 89 mg/g, and 91 mg/g, respectively. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043894193047
Publisher Site
http://dx.doi.org/10.1016/j.jhazmat.2019.04.047DOI Listing
April 2019
1 Read

The long-term stability of Fe-As coprecipitates at pH 4 and 7: Mechanisms controlling the arsenic behavior.

J Hazard Mater 2019 Apr 15;374:276-286. Epub 2019 Apr 15.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, China. Electronic address:

Hydrometallurgical Fe-As coprecipitates, which are amorphous in nature, could re-crystallize gradually and pose risks of contamination to the environment. However, the mechanisms controlling the As behavior when the Fe-As coprecipitates stored at different pHs is still not fully understood. This work systematically investigated the fate of As and the transformation process of the coprecipitates (Fe/As = ˜4) at different pHs and temperatures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2019.04.054DOI Listing

Microdermal Implants Show No Effect on Surrounding Tissue During Surgery With Electrocautery.

J Surg Res 2019 Apr 19;241:72-77. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington.

Background: Microdermal implants are an increasingly popular form of body jewelry. The potential for electrical conduction burn at the site of metal jewelry left in situ during electrosurgery has prompted surgical societies to recommend routine removal before surgery. To date, however, there is a lack of evidence to support this practice. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00224804193015
Publisher Site
http://dx.doi.org/10.1016/j.jss.2019.03.039DOI Listing
April 2019
1 Read

Speciation analysis of arsenic in urine samples from APL patients treated with single agent AsO by HPLC-HG-AFS.

J Pharm Biomed Anal 2019 Apr 8;171:212-217. Epub 2019 Apr 8.

Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Arsenic trioxide [AsO, arsenite (As) in solution] has been applied successfully for the treatment of acute promyelocytic leukemia (APL). The arsenic speciation analysis of urine is critical to reveal the metabolic mechanism and the relationship between arsenic species and the clinical response. To characterize the arsenic species in urine, a simple and robust HPLC-HG-AFS method was developed and validated to quantify the levels of arsenic species [As and its metabolites, monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenate (As)] in urine samples from 66 patients with APL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.04.014DOI Listing

Multi-class determination of steroid hormones and antibiotics in fatty hotpot ingredients by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2019 Apr 15;171:193-203. Epub 2019 Apr 15.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, 110016, Shenyang, Liaoning Province, PR China. Electronic address:

Due to the misuse of hormones and antibiotics resulting in drug residues in meat products, serious concerns have arisen regarding to the potential risks for human health. In this paper, a simple and efficient method was developed to simultaneously quantify six steroid hormones and six antibiotics in fatty foods by combining pressurized liquid extraction (PLE) with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Adsorbents, extraction temperature, extraction time, recycle time and several other parameters were optimized in current investigation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.04.019DOI Listing

A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice.

J Pharm Biomed Anal 2019 Apr 8;171:180-192. Epub 2019 Apr 8.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address:

The pathology of cholestatic liver injury (CLI) was complicated, which has limited the development of anti-cholestatic drugs for a long period. Metabolomic researches focused on global and dynamic changes of the organism could shed some light on mechanism investigation. In order to characterize and validate metabolite alterations of alpha-naphthylisothiocyanate (ANIT) induced CLI in C57BL/6 mice, a systemic metabolomic approach combining nontargeted HPLC-ESI-QTOF-MS and targeted UFLC-ESI-MS/MS technologies were developed innovatively. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07317085183291
Publisher Site
http://dx.doi.org/10.1016/j.jpba.2019.04.009DOI Listing
April 2019
1 Read

Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.

Phytomedicine 2018 Dec 10;59:152785. Epub 2018 Dec 10.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. Electronic address:

Background: Bavachin is a natural product isolated from Psoralea corylifolia L. that has been applied as a traditional medicine in Asian countries. However, the anti-inflammatory effects of bavachin on LPS-induced inflammation and NLRP3 inflammasome activation by macrophages remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.12.008DOI Listing
December 2018

Graphitic carbon nitride grown in situ on aldehyde-functionalized α-FeO: All-solid-state Z-scheme heterojunction for remarkable improvement of photo-oxidation activity.

J Colloid Interface Sci 2019 Apr 12;548:284-292. Epub 2019 Apr 12.

Key Laboratory of Soft Chemistry and Functional Materials, Nanjing University of Science and Technology, Ministry of Education, Nanjing 210094, PR China.

Aldehyde-functionalized α-FeO/graphitic carbon nitride (α-FeO-DBD/g-CN) was successfully synthesized through Schiff-based reaction between aromatic aldehydes in 3,4-dihydroxybenzaldehyde and NH groups in urea. The 3,4-dihydroxybenzaldehyde around α-FeO were advantageous to in situ growth of graphitic carbon nitride on α-FeO to form the contact interface by chemical bonds and beneficial to the electron transfer, leading to the formation of Z-scheme photocatalytic system. The α-FeO-DBD/g-CN photocatalysts exhibited a remarkable improvement in the degradation of bisphenol A (BPA) compared with bulk g-CN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2019.04.035DOI Listing

Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.

Leuk Res 2019 Apr 13;81:43-49. Epub 2019 Apr 13.

University of Colorado Division of Hematology, Aurora, CO, United States. Electronic address:

Background: Patients with relapsed and refractory (R/R) acute myeloid leukemia (AML) have limited treatment options. Genomically-defined personalized therapies are only applicable for a minority of patients. Therapies without identifiable targets can be effective but patient selection is challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2019.04.005DOI Listing

Two degrees of freedom, dynamic, hand-wrist EMG-force using a minimum number of electrodes.

J Electromyogr Kinesiol 2019 Apr 16;47:10-18. Epub 2019 Apr 16.

Worcester Polytechnic Institute, Worcester, MA 01609, USA. Electronic address:

Few studies have related the surface electromyogram (EMG) of forearm muscles to two degree of freedom (DoF) hand-wrist forces; ones that have, used large high-density electrode arrays that are impractical for most applied biomechanics research. Hence, we researched EMG-force in two DoFs-hand open-close paired with one wrist DoF-using as few as four conventional electrodes, comparing equidistant placement about the forearm to optimized site selection. Nine subjects produced 1-DoF and 2-DoF uniformly distributed random forces (bandlimited to 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10506411193003
Publisher Site
http://dx.doi.org/10.1016/j.jelekin.2019.04.003DOI Listing
April 2019
1 Read

Development and validation of a method for analysing of duloxetine, venlafaxine and amitriptyline in human bone.

Forensic Sci Int 2019 Apr 8;299:154-160. Epub 2019 Apr 8.

National Centre on Drug Addiction and Doping, Istituto Superiore di Sanità, Rome, Italy.

A method based on gas chromatography-mass spectrometry (GC-MS) is described for the determination of venlafaxine, amitriptyline and duloxetine in human bone. Pulverized samples were incubated in methanol for 1 h under ultrasonication, after the addition of sertraline as internal standard. The samples were centrifuged, and the supernatants were evaporated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.forsciint.2019.04.001DOI Listing

The value of manure - Manure as co-product in life cycle assessment.

J Environ Manage 2019 Apr 19;241:293-304. Epub 2019 Apr 19.

Innovation Center for U.S. Dairy, USA.

Livestock production is important for food security, nutrition, and landscape maintenance, but it is associated with several environmental impacts. To assess the risk and benefits arising from livestock production, transparent and robust indicators are required, such as those offered by life cycle assessment. A central question in such approaches is how environmental burden is allocated to livestock products and to manure that is re-used for agricultural production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.03.059DOI Listing

The use of rapid, small-scale column tests to determine the efficiency of bauxite residue as a low-cost adsorbent in the removal of dissolved reactive phosphorus from agricultural waters.

J Environ Manage 2019 Apr 19;241:273-283. Epub 2019 Apr 19.

Civil Engineering, National University of Ireland, Galway, Ireland. Electronic address:

Bauxite residue, the by-product produced in the alumina industry, is a potential low-cost adsorbent in the removal of phosphorus (P) from aqueous solution, due to its high composition of residual iron oxides such as hematite. Several studies have investigated the performance of bauxite residue in removing P; however, the majority have involved the use of laboratory "batch" tests, which may not accurately estimate its actual performance in filter systems. This study investigated the use of rapid, small-scale column tests to predict the dissolved reactive phosphorus (DRP) removal capacity of bauxite residue when treating two agricultural waters of low (forest run-off) and high (dairy soiled water) phosphorus content. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03014797193049
Publisher Site
http://dx.doi.org/10.1016/j.jenvman.2019.04.042DOI Listing
April 2019
2 Reads

Using SHAPE-MaP to probe small molecule-RNA interactions.

Methods 2019 Apr 19. Epub 2019 Apr 19.

Department of Biological Sciences, Auburn University, 120 W. Samford Ave, Rouse Life Sciences Building, Auburn, AL 36849, USA. Electronic address:

RNA is a regulator and catalyst of many cellular processes. Efforts to therapeutically harness RNA began with the discovery of myriad coding and non-coding RNAs and their versatile modes of action. However, due to its dynamic structure and the polar and repetitive nature of its surface, RNA presents a challenging target for drug design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2019.04.009DOI Listing

Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress.

Prostaglandins Other Lipid Mediat 2019 Apr 19. Epub 2019 Apr 19.

Institute for Food Toxicology, University of Veterinary Medicine Hannover, Hannover, Germany; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany. Electronic address:

In mammals, epoxy-polyunsaturated fatty acids (epoxy-PUFA) are enzymatically formed from naturally occurring all-cis PUFA by cytochrome P450 monooxygenases leading to the generation of cis-epoxy-PUFA (mixture of R,S- and S,R-enantiomers). In addition, also non-enzymatic chemical peroxidation gives rise to epoxy-PUFA leading to both, cis- and trans-epoxy-PUFA (mixture of R,R- and S,S-enantiomers). Here, we investigated for the first time trans-epoxy-PUFA and the trans/cis-epoxy-PUFA ratio as potential new biomarker of lipid peroxidation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prostaglandins.2019.04.004DOI Listing

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.

Semin Cancer Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

At present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated "bad luck" theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalized medicine, are genome-obsessed and focused on identifying and targeting these mutated genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.semcancer.2019.04.003DOI Listing

The European cross-border health data exchange roadmap: case study in the Italian setting.

J Biomed Inform 2019 Apr 19:103183. Epub 2019 Apr 19.

Insitute of Cristallography - CNR, Rome, Italy.

Health data exchange is a major challenge due to the sensitive information and the privacy issues entailed. Considering the European context, in which health data must be exchanged between different European Union (EU) Member States, each having a different national regulatory framework as well as different national healthcare system structures/organizations, the challenge is even greater. Europe has tried to address this challenge by launching in 2008, the epSOS ("Smart Open Services for European Patients") project, which was a European large-scale pilot on cross-border sharing of specific health data and services. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbi.2019.103183DOI Listing

In vivo and in vitro bioactivity of a "precursor of apatite" treatment on polyetheretherketone.

Acta Biomater 2019 Apr 19. Epub 2019 Apr 19.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We recently developed a surface treatment, "precursor of apatite" (PrA), for polyetheretherketone (PrA-PEEK) via a simple, low-temperature process aiming to achieve stronger and faster adhesion to bone. The treatment involves three steps: HSO immersion, exposure to O plasma discharge, and alkaline simulated body fluid (alkaline SBF) treatment. This method produces homogeneous fine particles of amorphous calcium phosphate on the PEEK, and we confirmed that PrA-PEEK had excellent apatite formation ability in an SBF immersion test. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S17427061193028
Publisher Site
http://dx.doi.org/10.1016/j.actbio.2019.04.041DOI Listing
April 2019
1 Read

Diffusion MRI using two-dimensional single-shot radial imaging (2D ss-rDWI) with variable flip angle and random view ordering.

Magn Reson Imaging 2019 Apr 19. Epub 2019 Apr 19.

Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States of America; Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States of America. Electronic address:

Purpose: The main objective of this study is to develop a 2D single-shot radial-DWI (2D ss-rDWI) technique to reduce motion artifacts and geometric distortion in DW images.

Method: A diffusion-preparation module is developed and applied prior to the data acquisition. Because the diffusion-prepared longitudinal magnetization is measured over multiple RF excitations in each shot, 2D ss-rDWI is subject to low signal-to-noise ratio (SNR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2019.04.008DOI Listing

Protein nanotubes as state-of-the-art nanocarriers: Synthesis methods, simulation and applications.

J Control Release 2019 Apr 19. Epub 2019 Apr 19.

Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Science and Natural Resources, Gorgan, Iran. Electronic address:

Application of food proteins as a tool to form nanostructures (especially nanotubular shapes) has been an interesting topic for both the food and pharmaceutical sectors. Organic and protein nanostructures have better biocompatibility and biodegradability compared to inorganic counterparts like carbon nanotubes; in addition, they can undergo surface modifications. Several organic nanotubes have been developed, meanwhile, the engineered protein nanotubes in the food science have been prepared from α-lactalbumin, ovalbumin, cyclic peptide nanotubes, collagen, bovine serum albumin, lysozyme and hydrophobins which are of great interest to be applied in the food industry considering their outstanding properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2019.04.026DOI Listing

Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse.

Physiol Behav 2019 Apr 19. Epub 2019 Apr 19.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Electronic address:

Capsaicin (CAP), the pungent ingredient of hot red pepper, is a selective ligand for the heat-sensitive transient receptor potential V1 cation channel 1 (TRPV1). Although CAP has been traditionally used as the ingredient of spices for various foods in the world, the effect of oral intake of CAP on thermoregulation and locomotor activity, and CAP-induced activation of brain neural circuits are not well understood. In this study, therefore, we examined the effects of oral gavage of CAP on core body and tail surface temperature, locomotor activity, and Fos expression in thermoregulation- and sensory information-associated hypothalamic and medullary brain regions using freely moving mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2019.04.015DOI Listing

Effect of waterpipe tobacco smoke exposure during lactation on learning and memory of offspring rats: Role of oxidative stress.

Life Sci 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Aims: The prevalence of waterpipe tobacco smoking is increasing among breastfeeding women. Herein, the effect of maternal waterpipe tobacco smoke (WTS) exposure during lactation on learning and memory of adult offspring rats was examined.

Main Methods: Lactating rats received either fresh air or mainstream WTS (1 h twice daily) from day 4 to day 21. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.04.049DOI Listing

Tissue Clearing and Its Application to Bone and Dental Tissues.

J Dent Res 2019 Apr 22:22034519844510. Epub 2019 Apr 22.

1 Department of Restorative Sciences, School of Dentistry, Texas A&M University, Dallas, TX, USA.

Opaqueness of animal tissue can be attributed mostly to light absorption and light scattering. In most noncleared tissue samples, confocal images can be acquired at no more than a 100-µm depth. Tissue-clearing techniques have emerged in recent years in the neuroscience field. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0022034519844510DOI Listing

Perspective and guidelines for metaproteomics in microbiome studies.

J Proteome Res 2019 Apr 22. Epub 2019 Apr 22.

The microbiome is emerging as a prominent factor affecting human health and its dysbiosis is associated with various diseases. Compositional profiling of microbiome is increasingly being supplemented with functional characterization. Metaproteomics is intrinsically focused on functional changes and therefore will be an important tool in those studies of the human microbiome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.9b00054DOI Listing

Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans.

J Trauma Stress 2019 Apr;32(2):226-237

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.

We developed an algorithm for identifying U.S. veterans with a history of posttraumatic stress disorder (PTSD), using the Department of Veterans Affairs (VA) electronic medical record (EMR) system. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jts.22399
Publisher Site
http://dx.doi.org/10.1002/jts.22399DOI Listing
April 2019
1 Read

Gas chromatography mass spectrometry analysis of non-hydrolyzed sulfated steroids by degradation product formation.

Drug Test Anal 2019 Apr 22. Epub 2019 Apr 22.

Department of Diagnostic Sciences, Doping Control Laboratory, Ghent University, Technologiepark 30 B, B-9052, Zwijnaarde, Belgium.

Steroid detection and identification remains a key issue in toxicology, drug testing, medical diagnostics, food safety control and doping control. In this study, we evaluate the capabilities and usefulness of analyzing non-hydrolyzed sulfated steroids with gas chromatography mass spectrometry (GC-MS) instead of the conventionally applied liquid chromatography MS (LC-MS) approach. Sulfates of 31 steroids were synthesized and their MS and chromatographic behavior was studied by chemical ionization GC triple quadrupole MS (CI GC-MS/MS) and low energy electron ionization GC quadrupole time-of-flight MS (LE-EI GC-QTOF-MS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dta.2606DOI Listing

Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy.

PLoS One 2019 22;14(4):e0215547. Epub 2019 Apr 22.

Department of Mathematics, Konkuk University, Seoul, Republic of Korea.

Glioblastoma multiforme is one of the most invasive type of glial tumors, which rapidly grows and commonly spreads into nearby brain tissue. It is a devastating brain cancer that often results in death within approximately 12 to 15 months after diagnosis. In this work, optimal control theory was applied to regulate intracellular signaling pathways of miR-451-AMPK-mTOR-cell cycle dynamics via glucose and drug intravenous administration infusions. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215547PLOS

Quantifying the effect of Jacobiasca lybica pest on vineyards with UAVs by combining geometric and computer vision techniques.

PLoS One 2019 22;14(4):e0215521. Epub 2019 Apr 22.

Agroforestry and Cartography Precision Research Group, Institute for Regional Development, University of Castilla-La Mancha, Albacete, Spain.

With the increasing competitiveness in the vine market, coupled with the increasing need for sustainable use of resources, strategies for improving farm management are essential. One such effective strategy is the implementation of precision agriculture techniques. Using photogrammetric techniques, the digitalization of farms based on images acquired from unmanned aerial vehicles (UAVs) provides information that can assist in the improvement of farm management and decision-making processes. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215521PLOS
April 2019
1 Read

Influence of spatial camera resolution in high-speed videoendoscopy on laryngeal parameters.

PLoS One 2019 22;14(4):e0215168. Epub 2019 Apr 22.

Dep. of Otorhinolaryngology, Div. of Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

In laryngeal high-speed videoendoscopy (HSV) the area between the vibrating vocal folds during phonation is of interest, being referred to as glottal area waveform (GAW). Varying camera resolution may influence parameters computed on the GAW and hence hinder the comparability between examinations. This study investigates the influence of spatial camera resolution on quantitative vocal fold vibratory function parameters obtained from the GAW. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215168PLOS

Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm.

PLoS Comput Biol 2019 Apr 22;15(4):e1006842. Epub 2019 Apr 22.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America.

Many proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006842DOI Listing

Expression estimation and eQTL mapping for HLA genes with a personalized pipeline.

PLoS Genet 2019 Apr 22;15(4):e1008091. Epub 2019 Apr 22.

Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.

The HLA (Human Leukocyte Antigens) genes are well-documented targets of balancing selection, and variation at these loci is associated with many disease phenotypes. Variation in expression levels also influences disease susceptibility and resistance, but little information exists about the regulation and population-level patterns of expression. This results from the difficulty in mapping short reads originated from these highly polymorphic loci, and in accounting for the existence of several paralogues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1008091DOI Listing

Does the Expectancy on the Static Stretching Effect Interfere With Strength-Endurance Performance?

J Strength Cond Res 2019 Apr 17. Epub 2019 Apr 17.

Strength Training Study and Research Group, Institute of Health Sciences, Paulista University, Sao Paulo, Sao Paulo, Brazil.

Bertolaccini, AL, da Silva, AA, Teixeira, EL, Schoenfeld, BJ, and de Salles Painelli, V. Does the expectancy on the static stretching effect interfere with strength-endurance performance? J Strength Cond Res XX(X): 000-000, 2019-Static stretching (SS) may interfere with strength performance. Such interference, however, may be partially attributed to the subjects' or researcher's expectancy about the SS effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1519/JSC.0000000000003168DOI Listing

Dietary Strategies of Modern Bodybuilders During Different Phases of the Competitive Cycle.

J Strength Cond Res 2019 Apr 17. Epub 2019 Apr 17.

Strength Training Study and Research Group, Institute of Health Sciences, Paulista University, Sao Paulo, Sao Paulo, Brazil.

Lenzi, JL, Teixeira, EL, de Jesus, G, Schoenfeld, BJ, and de Salles Painelli, V. Dietary strategies of modern bodybuilders during different phases of the competitive cycle. J Strength Cond Res XX(X): 000-000, 2019-Bodybuilders have used a wide array of nutritional strategies over the years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1519/JSC.0000000000003169DOI Listing

Transference Effect of Short-Term Optimum Power Load Training on the Punching Impact of Elite Boxers.

J Strength Cond Res 2019 Apr 17. Epub 2019 Apr 17.

Sports Performance Research Institute New Zealand (SPRINZ), Auckland University of Technology, Auckland, New Zealand.

Loturco, I, Pereira, LA, Kobal, R, Fernandes, V, Reis, VP, Romano, F, Alves, M, Freitas, TT, and McGuigan, M. Transference effect of short-term optimum power load training on the punching impact of elite boxers. J Strength Cond Res XX(X): 000-000, 2019-This study examined the changes in bench press (BP), jump squat (JS), and half-squat (HS) power outputs induced by a short-term (1 week) training scheme based on the optimum power load (OPL) applied to national boxing athletes and measured the transference effect coefficient (TEC) of these exercises on punching impact. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1519/JSC.0000000000003165DOI Listing

Autoregulation by "Repetitions in Reserve" Leads to Greater Improvements in Strength Over a 12-Week Training Program Than Fixed Loading.

J Strength Cond Res 2019 Apr 17. Epub 2019 Apr 17.

Faculty of Sport, Health and Applied Science, St Mary's University, Twickenham, United Kingdom.

Graham, T and Cleather, DJ. Autoregulation by "repetitions in reserve" leads to greater improvements in strength over a 12-week training program than fixed loading. J Strength Cond Res XX(X): 000-000, 2019-Autoregulated (AR) training involves altering resistance session parameters based on the athlete's readiness to train. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1519/JSC.0000000000003164DOI Listing
April 2019
1 Read

Applied Pediatric Math: Bridging the Gap Between Theory and Practice for a Diverse Group of Learners.

Nurs Educ Perspect 2019 May/Jun;40(3):181-183

About the Authors Glenn Murphy, MSN, RN, CNE, is an assistant clinical professor, Drexel University College of Nursing, Chalfont, Pennsylvania. Jackie Murphy, MSN, RN, CPN, CNE, is an assistant clinical professor, Drexel University College of Nursing. For more information, contact Glenn Murphy at

A gap exists between didactic theory and clinical practice when nursing students learn clinical calculations. Educators can provide innovative classroom teaching methods using practical mathematics to decrease this gap. In the simulation lab, students complete weight-based calculations and then administer medications as part of medication skills stations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.NEP.0000000000000309DOI Listing

S100B Serum Elevation Predicts In-Hospital Mortality After Brain Arteriovenous Malformation Rupture.

Stroke 2019 May;50(5):1250-1253

Neurosurgical Anesthesiology and Critical Care (C.A., A.J., V.D.), Pitié-Salpêtrière Hospital (PSL), Paris, France.

Background and Purpose- S100B protein serum elevation has been associated with poor prognosis in neurologically ill patients. The purpose of this study is to determine whether elevation of S100B is associated with increased in-hospital mortality after brain arteriovenous malformation rupture. Methods- This is a retrospective study of patients admitted for brain arteriovenous malformation rupture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/STROKEAHA.119.025033DOI Listing

Effects of pH and Application Technique of In-office Bleaching Gels on Hydrogen Peroxide Penetration into the Pulp Chamber.

Oper Dent 2019 Apr 22. Epub 2019 Apr 22.

Objective: This study aimed to quantify the penetration of hydrogen peroxide (HP) into the pulp chamber in teeth submitted to in-office bleaching with varied pH and application techniques. The color change and pH of the in-office bleaching product during application was also evaluated.

Methods And Materials: Ninety-six human premolars were used and randomly divided into 10 groups (n=9) according to the following combination of factors: pH of in-office bleaching agents (two neutral/alkaline pH: Opalescence Boost 38% and Whiteness HP Blue 35% and three acidic pH: Whiteness HP Maxx 35%, Lase Peroxide Sensy 35%, and Total Blanc Office 35%) and application modes (for 3 × 15 minutes [3×15] and 1 × 45 minutes [1×45]). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2341/18-148-LDOI Listing

Economic burden and associated factors of measles patients in Zhejiang Province, China.

Hum Vaccin Immunother 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Department of Immunization Program , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , PR China.

This study aimed to figure out the economic burden of measles patients and explore the associated factors for total cost in measles cases that occurred in the year 2015 from Jiaxing, Jinhua, and Taizhou cities in Zhejiang Province, China. Direct interviews were conducted to collect information on patient expenses during treatment, including outpatient expenses, hospitalization expenses, self-treatment fees, productivity loss, and transportation fees. Descriptive epidemiological methods and chi-square tests were used to assess the direct and indirect cost of measles patients. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21645515.2019.1
Publisher Site
http://dx.doi.org/10.1080/21645515.2019.1599673DOI Listing
April 2019
1 Read

Implementation, evaluation, and outcome of TeamSTEPPS in interprofessional education: a scoping review.

J Interprof Care 2019 Apr 22:1-10. Epub 2019 Apr 22.

a McGovern Medical School , The University of Texas Health Science Center , Houston , TX , USA.

The ability to effectively work in interprofessional teams is listed as one of the five core competencies in health professions education. Though the importance of interprofessional education (IPE) has been established, results of studies have been difficult to compare due to the high variability of programs. We undertook a scoping review to examine the use of a prescribed curriculum, TeamSTEPPS, in IPE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13561820.2019.1594729DOI Listing

A vocabulary describing health-terms of movement quality - a phenomenological study of movement communication.

Disabil Rehabil 2019 Apr 22:1-10. Epub 2019 Apr 22.

e Department of Journalism and Communication , University Carlos III of Madrid , Madrid , Spain.

Purpose: The aim of the study was to develop a vocabulary targeting communication of health-terms of movement quality, establishing professional knowledge of a movement terminology usefull within rehabilitation.

Methods: A phenomenological study design was chosen, inviting movement experts working in rehabilitation to describe movement observations when a change into more functional, health related ways of moving appeared in the rehabilitation processes. 15 physiotherapy experts were recruited, five from the field of neurology, primary health care and psychiatry. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/09638288.2019.1
Publisher Site
http://dx.doi.org/10.1080/09638288.2019.1585970DOI Listing
April 2019
1 Read

Influence of the Urban Exposome on Birth Weight.

Environ Health Perspect 2019 Apr;127(4):47007

4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

Objective: We evaluated the association of the urban exposome with birth weight. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1289/EHP3971DOI Listing
  • Page 1 of 19156