1,060,356 results match your criteria Applied Physics Express[Journal]


Ethical Framework for Nutrition Support Resource Allocation During Shortages: Lessons From COVID-19.

Nutr Clin Pract 2020 Jun 3. Epub 2020 Jun 3.

Didactic Program in Dietetics, Department of Nutrition Food Studies, New York University/Steinhardt, New York, New York, USA.

The coronavirus disease (COVID-19) pandemic has impacted all aspects of our population. The "Troubling Trichotomy" of what can be done technologically, what should be done ethically, and what must be done legally is a reality during these unusual circumstances. Recent ethical considerations regarding allocation of scarce resources, such as mechanical ventilators, have been proposed. Read More

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http://dx.doi.org/10.1002/ncp.10500DOI Listing

[Update diagnosis and therapeutic management of pulmonary embolism].

Dtsch Med Wochenschr 2020 Jun 3;145(11):710-715. Epub 2020 Jun 3.

Medizinische Klinik mit Schwerpunkt Kardiologie, Campus Virchow-Klinikum (CVK), Charité-Universitätsmedizin Berlin.

Pulmonary embolism (PE) is a life-threatening disease and the third most frequent cardiovascular cause of death after stroke and myocardial infarction. The annual incidence is increasing. The recently published 2019 guidelines of the European Society of Cardiology integrate numerous new study findings and provide updated diagnostic and therapeutic algorithms. Read More

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http://dx.doi.org/10.1055/a-0984-7323DOI Listing

Morphological Classification of the Zygomatic Regions in Young Chinese Han Males and Females Based on a Simulated Moiré Pattern.

Facial Plast Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Plastic and Reconstructive Surgery, Peking University Third Hospital, Beijing, China.

The complex curved contours of the zygomatic regions are difficult to analyze. Therefore, a better evaluation medium must be developed. We aimed to examine and summarize the morphological characteristics of the zygomatic region by using a moiré pattern map and computer algorithm. Read More

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http://dx.doi.org/10.1055/s-0040-1712163DOI Listing

Correction: Anaerobic and Agility Parameters of Salonists in Laboratory and Field Tests.

Int J Sports Med 2020 Jun 3. Epub 2020 Jun 3.

Laboratory of Applied Sport Physiology, School of Applied Sciences, University of Campinas, Limeira, Brazil.

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http://dx.doi.org/10.1055/a-1185-7374DOI Listing

Regional heterogeneity of cerebral hemodynamics in mild neonatal encephalopathy measured with multichannel near-infrared spectroscopy.

Pediatr Res 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Neuromonitoring at the bedside is the key to understand the pathophysiological mechanisms of brain injury associated with neonatal encephalopathy. The current practice is to monitor the forehead using a noninvasive cerebral oximetry-it remains unknown to what extent cerebral hemodynamics in other brain regions is different to the frontal region.

Method: A multichannel near-infrared spectroscopy (NIRS) system was used to monitor neonates (n = 14) with fetal acidosis and mild neonatal encephalopathy at four brain regions (the frontal, posterior, left temporal, and right temporal lobes). Read More

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http://dx.doi.org/10.1038/s41390-020-0992-5DOI Listing

Stage-by-stage formation of superficial nanostructures in ITO films reduced by H2-GD at low temperature (100 °C) for applications on plastic substrates.

Nanotechnology 2020 Jun 3. Epub 2020 Jun 3.

Electronics Engineering , Universidad Autónoma de Tamaulipas, Victoria, Tamaulipas, MEXICO.

The formation of superficial nanostructures (SNs) in reduced indium tin oxide (ITO) thin films by H2-Glow discharge (GD) at a low reduction temperature (T=100 °C) was investigated. Sputtered ITO films deposited at low (T=100 °C) and high (T=300 °C) temperatures were reduced using this low-temperature process. Scanning electron and atomic force microscopy were applied to study the evolution of the nanostructural features and three stages were identified: emerging/densification, coalescence, and depletion stages. Read More

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http://dx.doi.org/10.1088/1361-6528/ab991eDOI Listing

Flexible piezoelectric nanogenerators based on CdS nanowall for self-powered sensors.

Nanotechnology 2020 Jun 3. Epub 2020 Jun 3.

Department of Applied Physics, Chongqing University, Chongqing, CHINA.

Wurtzite-structured CdS material is widely used in information sensing and energy harvesting. Based on the piezoelectric property of CdS, we present a flexible piezoelectric nanogenerator (PENG) with three-dimensional structure CdS nanowall arrays. Under the index finger oscillates at a slow rate, the maximal open-circuit voltage and short-circuit current are 1. Read More

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http://dx.doi.org/10.1088/1361-6528/ab991fDOI Listing

Hydrothermally grown ZnO nanowire array as an oxygen vacancies reservoir for improved resistive switching.

Nanotechnology 2020 Jun 3. Epub 2020 Jun 3.

Applied Science and Technology, Politecnico di Torino, C so Duca degli Abruzzi 24, 10129 Torino, Torino, ITALY.

Resistive switching (RS) devices based on self-assembled nanowires (NWs) and nanorods (NRs) represent a fascinating alternative to conventional devices with thin film structure. The high surface-to-volume ratio may indeed provide the possibility of modulating their functionalities through surface effects. However, devices based on NWs usually suffer from low resistive switching performances in terms of operating voltages, endurance and retention capabilities. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9920DOI Listing

A luminescent solar concentrator ray tracing simulator with a graphical user interface: Features and applications.

Methods Appl Fluoresc 2020 Jun 3. Epub 2020 Jun 3.

University of Melbourne School of Chemistry, Parkville, Victoria, AUSTRALIA.

A Monte-Carlo ray tracing simulator with a graphical user interface (MCRTS-GUI) has been developed to provide a quantitative description, performance evaluation and photon loss analysis of luminescent solar concentrators (LSCs). The algorithm is applied to several practical LSC device structures including multiple dyes in the same waveguiding layer, and structures where a dye layer is sandwiched between clear substrates. The effect of the host matrix absorption and the influence of the neighboring layers are investigated. Read More

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http://dx.doi.org/10.1088/2050-6120/ab993dDOI Listing

Averting cumulative lifetime attributable risk (LAR) of cancer by decontamination of residential areas affected by a large-scale nuclear power plant fallout: Time aspects of radiological benefits for newborns and adults.

J Radiol Prot 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiation Physics, Sahlgrenska University Hospital, Guthenburg, SWEDEN.

The averted cumulative lifetime attributable risk (LAR), the residual dose and highest ground deposition ofCs complying with a reference dose level of 20 mSv yto an individual returning after one year to an area contaminated by nuclear power plant (NPP) fallout were evaluated by applying an existing exposure model designed to compute age- and gender-dependent time-integrated LAR. The model was applied to four types of nuclear fallout scenarios, partly based on data from the Chernobyl and Fukushima releases and from theoretical source terms from Swedish NPPs. For rapid decontamination measures that achieve a 50% relative reduction in external dose rate within 1 y, compliance with the reference level 20 mSv ycan be attained for an initialCs ground deposition of up to 2 MBq mwith relaxed food restrictions. Read More

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http://dx.doi.org/10.1088/1361-6498/ab993aDOI Listing

Optimizing neuromodulation based on surrogate neural states for seizure suppression in a rat temporal lobe epilepsy model.

J Neural Eng 2020 Jun 3. Epub 2020 Jun 3.

Neurosurgery, Emory University, Atlanta, Georgia, UNITED STATES.

Objective: Developing a new neuromodulation method for epilepsy treatment requires a large amount of time and resources to find effective stimulation parameters and often fails due to inter-subject variability in stimulation effect. As an alternative, we present a novel data-driven surrogate approach which can optimize the neuromodulation efficiently by investigating the stimulation effect on surrogate neural states.

Approach: Medial septum (MS) optogenetic stimulation was applied for modulating electrophysiological activities of the hippocampus in a rat temporal lobe epilepsy model. Read More

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http://dx.doi.org/10.1088/1741-2552/ab9909DOI Listing

Gastric adenocarcinoma appearance in leiomyoma: A case report.

Int J Surg Case Rep 2020 May 29;71:327-330. Epub 2020 May 29.

Department of Surgery, National Hospital Organization, Kure Medical Center, Chugoku Cancer Center, 3-1 Aoyama, Kure City, Hiroshima, 737-0023, Japan; Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Introduction: We experienced an extremely rare case of gastric adenocarcinoma wrapped by leiomyoma.

Presentation Of Case: A 65-year-old man had an abnormality (filling defect) of the upper gastrointestinal series in his first medical checkup five years prior. Esophagogastroduodenoscopy detected a 10 mm submucosal tumor-like lesion in the greater curvature of the upper gastric remnant body. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.050DOI Listing

Simultaneous determination of phenazopyridine HCl and trimethoprim in presence of phenazopyridine HCl impurity by univariate and multivariate spectrophotometric methods - Quantification of phenazopyridine HCl impurity by univariate methods.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 21;239:118516. Epub 2020 May 21.

Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Science and Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt.

Three univariate and two multivariate spectrophotometric methods were developed and subsequently validated to determine phenazopyridine HCl (PHZ) and trimethoprim (TMP) in the presence of 2,6-Diaminopyridine (2,6-DAP). The first univariate method depends on direct determination of phenazopyridine by measuring its absorbance at 412 nm and performed in concentration range of 1.00-10. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118516DOI Listing

Effects of assist parameter on the performance of proportional assist ventilation in a lung model of chronic obstructive pulmonary.

Respir Med Res 2020 May 15;78:100766. Epub 2020 May 15.

Department of respiratory medicine, Shanghai The First People's hospital, Shanghai Jiao Tong university, 200080 Shanghai, China.

Background: How the assist parameters affect synchronization and inspiratory workload in proportional assist ventilation (PAV) remains unknown.

Purpose: This bench study aimed to optimize the PAV parameters by evaluating their effects on patient-ventilator synchrony and work of breathing (WOB) in a chronic obstructive pulmonary disease (COPD) model during noninvasive ventilation, compared with the pressure support ventilation (PSV) mode.

Methods: The Respironics V60 ventilator was connected to an ASL5000 lung simulator, which simulates lung mechanics in COPD (compliance, 50mL/cmHO; expiratory resistance, 20 cmHO/L/s; respiratory rate, 15 breaths/min; inspiratory time, 1. Read More

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http://dx.doi.org/10.1016/j.resmer.2020.100766DOI Listing

Discriminant validity and reproducibility of spatiotemporal and kinetic parameters during treadmill walking in patients with knee osteoarthritis.

Gait Posture 2020 May 31;80:77-79. Epub 2020 May 31.

Human Performance Lab, Schulthess Clinic, Zurich, Switzerland. Electronic address:

Background: Instrumented treadmills are potentially useful tools for the assessment of gait parameters in orthopaedic clinical settings, but their measurement properties remain uncertain.

Research Question: What is the discriminant validity and reproducibility of spatiotemporal and kinetic gait parameters measured by a pressure-instrumented treadmill at different speeds and inclinations in patients with knee osteoarthritis (KOA)?

Methods: A total of 54 patients with unilateral KOA and 23 healthy controls took part in the study. Step length, single-limb support duration and ground reaction force were recorded during level and uphill walking at 3 and 4 km/h using a commercially-available treadmill instrumented with an integrated pressure platform. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.04.002DOI Listing

Rising vegetation activity dominates growing water use efficiency in the Asian permafrost region from 1900 to 2100.

Sci Total Environ 2020 May 21;736:139587. Epub 2020 May 21.

Biology Department, San Diego State University, San Diego, CA 92182, USA. Electronic address:

Permafrost play an important role in regulating global climate system. We analyzed the gross primary productivity (GPP), net primary productivity (NPP), and evapotranspiration (ET) derived from MODIS and three earth system models participated in the Coupled Model Inter-comparison Project Phase 6 (CMIP6) in the Asian permafrost region. The water use efficiency (WUE) was further computed. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139587DOI Listing

Impact of COVID-19 outbreak measures of lockdown on the Italian Carbon Footprint.

Sci Total Environ 2020 May 29;737:139806. Epub 2020 May 29.

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde, Denmark. Electronic address:

Stringent lockdown measures implemented in Italy to mitigate the spread of COVID-19 are generating unprecedented economic impacts. However, the environmental consequences associated with the temporary shutdown and recovery of industrial and commercial activities are still not fully understood. Using the well-known carbon footprint (CF) indicator, this paper provides a comprehensive estimation of environmental effects due to the COVID-19 outbreak lockdown measures in Italy. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139806DOI Listing

Structural extracellular polymeric substances determine the difference in digestibility between waste activated sludge and aerobic granules.

Water Res 2020 May 16;181:115924. Epub 2020 May 16.

Section Sanitary Engineering, Department of Water Management, Faculty of Civil Engineering and Geosciences, Delft University of Technology, Stevinweg 1, 2628, CN, Delft, the Netherlands.

Aerobic granular sludge (AGS) technology is an alternative to conventional activated sludge to reduce the process footprint and energy consumption. Strategies for the efficient management of its produced biomass, that is grown in a granular morphology as well, need further development. Anaerobic digestion (AD) is commonly applied in waste activated sludge (WAS) treatment and is a potential option also for produced AGS treatment. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115924DOI Listing

Primary Care Accessibility Effects on Health Care Utilization among Urban Children.

Acad Pediatr 2020 May 31. Epub 2020 May 31.

Applied Clinical Research Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104. Electronic address:

Objectives: Evidence suggests that spatial accessibility to primary care is a contributing factor to appropriate health care utilization, with limited primary care access resulting in avoidable hospitalizations and emergency department visits which are burdensome on individuals and our healthcare system. Limited research, however, has examined the effects on children.

Methods: We evaluated associations of spatial accessibility to primary care on health care utilization among a sample of 16,709 children aged 0-3 years in Philadelphia who were primarily non-White and publicly insured. Read More

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http://dx.doi.org/10.1016/j.acap.2020.05.014DOI Listing

Combined biochar and nitrogen application stimulates enzyme activity and root plasticity.

Sci Total Environ 2020 May 14;735:139393. Epub 2020 May 14.

Department of Environmental Chemistry, University of Kassel, Nordbahnhofstraße 1a, 37213 Witzenhausen, Germany.

Biochar (BC) and nitrogen (N) fertilizers are frequently applied to improve soil properties and increase crop productivity. Nonetheless, our mechanistic understanding of plant-soil interactions under single or combined application of BC and N remains incomplete. For the first time, we applied a split-root system to evaluate how BC or N contributes to the changes in soil enzyme activities, N and phosphorus (P) cycling as well as root plasticity. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139393DOI Listing

Neuroendoscope-Assisted Aneurysm Trapping for Ruptured Intraventricular Aneurysms in Moyamoya Disease Patients: A Case Report.

World Neurosurg 2020 May 31. Epub 2020 May 31.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita, Sapporo 060-8638, Japan.

Background: Intracranial hematomas associated with abnormal collateral vessels are observed in certain populations of adult patients with moyamoya disease (MMD). Of these, intraventricular hematomas resulting from rupture of intraventricular aneurysms, which are formed along an abnormal peripheral choroidal artery, are sometimes detected and could be severe. No appropriate treatment option for these ruptured aneurysms has been well established to date. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.222DOI Listing

Tic frequency and behavioural measures of cognitive control are improved in individuals with Tourette syndrome by aerobic exercise training.

Cortex 2020 Mar 29;129:188-198. Epub 2020 Mar 29.

School of Psychology, University of Nottingham, UK.

Previous observations of improvements in cognition in typically developing children following moderate to vigorous exercise (e.g., Budde, Voelcker-Rehage, Pietrabyk-Kendziorra, Ribeiro, & Tidow, 2008; Hillman et al. Read More

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http://dx.doi.org/10.1016/j.cortex.2020.01.029DOI Listing

Neuro4Neuro: A neural network approach for neural tract segmentation using large-scale population-based diffusion imaging.

Neuroimage 2020 May 31:116993. Epub 2020 May 31.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.

Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly characterized from brain diffusion MRI. In addition, to enable analysis of WM tracts in large datasets and in clinical practice it is essential to have methodology that is fast and easy to apply. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2020.116993DOI Listing

Targeting metabolic syndrome with phytochemicals: Focus on the role of molecular chaperones and hormesis in drug discovery.

Pharmacol Res 2020 May 31:104925. Epub 2020 May 31.

Truba Institute of Pharmacy, Karond-Gandhi Nagar, By Pass Road, Bhopal, 462038, India. Electronic address:

Adaptive cellular stress response confers stress tolerance against inflammatory and metabolic disorders. In response to metabolic stress, the key mediator of cellular adaptation and tolerance is a class of molecules called the molecular chaperones (MCs). MCs are highly conserved molecules that play critical role in maintaining protein stability and functionality. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104925DOI Listing

Linking Bodily, Environmental and Mental States In the Self - A Three-level Model Based on A Meta-analysis.

Neurosci Biobehav Rev 2020 May 31. Epub 2020 May 31.

Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada; Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, China.

Current researchers mostly agree that the self consists of both bodily and non-bodily environmental information. The neural mechanism underlying the integration of this information remains unclear. In this study, we propose a neural model subdividing self-processing into three intimately connected levels with different extension: Interoceptive-processing, Exteroceptive-processing and Mental-self-processing. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2020.05.004DOI Listing

Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics.

Biochim Biophys Acta Rev Cancer 2020 May 31:188381. Epub 2020 May 31.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX, USA. Electronic address:

The United State Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable These accounts to an urgent clinical need to discover natural compounds with precisely safe and highly efficient for the cancer prevention and cancer therapy. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188381DOI Listing

Use of Static Cutoffs of Hypertension to Determine High cIMT in Children and Adolescents: An International Collaboration Study.

Can J Cardiol 2020 Mar 4. Epub 2020 Mar 4.

Department of Epidemiology, School of Public Health, Shandong University, Jinan, China. Electronic address:

Background: Pediatric hypertension is typically defined as blood pressure ≥ sex-, age-, and height-specific 95th percentile (high) cutoffs. Given the number of strata, there are hundreds of cutoffs for defining elevated and high blood pressure that make it cumbersome to use in clinical practice. This study aimed to evaluate the utility of the static cutoffs for pediatric hypertension (120/80 mm Hg for children and 130/80 mm Hg for adolescents) in determining high carotid intimamedia thickness (cIMT) in children and adolescents. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.02.093DOI Listing

Finite Temperature TD-DMRG for the Carrier Mobility of Organic Semiconductors.

J Phys Chem Lett 2020 Jun 3. Epub 2020 Jun 3.

A large number of non-adiabatic dynamical studies have been applied to reveal the nature of carrier transport in organic semiconductors with different approximations. We present here a "nearly exact" graphical process unit (GPU) based finite temperature TD-DMRG method to evaluate the carrier mobility in organic semiconductors as described by electron-phonon model, in particular to rubrene crystal, one of the prototypical organic semiconductors, with parameters derived from first-principles. We find that (i) TD-DMRG is a general and robust method that can bridge the gap between hopping and band picture covering a wide range of electronic coupling strength; and (ii) with realistic parameters, TD-DMRG is able to account for the experimentally observed "band-like" transport behavior (∂μ/∂T<0) in rubrene. Read More

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http://dx.doi.org/10.1021/acs.jpclett.0c01072DOI Listing

Synthesis of methyl-capped TiO-SiO Janus Pickering Emulsifiers for Selective Photodegradation of Water-soluble Dyes.

ACS Appl Mater Interfaces 2020 Jun 3. Epub 2020 Jun 3.

Recently, Pickering emulsion stabilized by Janus particles have received considerable attention for interfacial reactions and droplet manipulation. However, its potential interests have been rarely explored because of the difficulties in designing and fabricating Janus particle for Pickering emulsion with suitable applications. Also, photocatalytic materials are scarcely applied as emulsifiers in Pickering emulsions because of their photo-generated hydrophilicity. Read More

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http://dx.doi.org/10.1021/acsami.0c01064DOI Listing

Triatoma brasiliensis species complex: characterization of the external female genitalia.

J Vector Ecol 2020 Jun;45(1):57-68

Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Campus Araraquara, São Paulo, Brasil.

The Triatoma brasiliensis complex is composed of six species (Triatoma bahiensis, T. juazerensis, T. lenti, T. Read More

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http://dx.doi.org/10.1111/jvec.12373DOI Listing

Skin irritation potential of cosmetic preservatives: An exposure-relevant study.

J Cosmet Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Cosmetics, School of Science, Beijing Technology and Business University, Beijing, China.

Background: Preservatives represent one of the main causes of skin irritation and contact allergies.

Aims: To comprehensively evaluate the skin irritation potential of phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, and DMDM hydantoin under regulatory acceptable concentrations.

Methods: A patch test and repeated open application test (ROAT) were applied to evaluate skin irritation in vivo. Read More

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http://dx.doi.org/10.1111/jocd.13502DOI Listing

Clinical Manifestations of Children with COVID-19: a Systematic Review.

Pediatr Pulmonol 2020 Jun 3. Epub 2020 Jun 3.

Pediatric Intensive Care Unit, Department of Pediatrics, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

Background: The coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. The aim of this study was to describe the clinical, laboratorial and radiological characteristics of children with COVID-19. Read More

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http://dx.doi.org/10.1002/ppul.24885DOI Listing

Conditional safety margins for less conservative peak local SAR assessment: A probabilistic approach.

Magn Reson Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Purpose: The introduction of a linear safety factor to address peak local specific absorption rate (pSAR ) uncertainties (eg, intersubject variation, modeling inaccuracies) bears one considerable drawback: It often results in over-conservative scanning constraints. We present a more efficient approach to define a variable safety margin based on the conditional probability density function of the effectively obtained pSAR value, given the estimated pSAR value.

Methods: The conditional probability density function can be estimated from previously simulated data. Read More

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http://dx.doi.org/10.1002/mrm.28335DOI Listing

The epidemiology of kicking injuries in professional Rugby Union: a 15-season prospective study.

Scand J Med Sci Sports 2020 Jun 3. Epub 2020 Jun 3.

Applied Sports, Technology, Exercise and Medicine Research Centre, Swansea University, Swansea, UK.

Purpose: Whilst kicking in Rugby Union can be influential to match outcome, the epidemiology of kicking injuries remains unknown. This study therefore aimed to investigate the epidemiology of injuries attributed to kicking in professional rugby, including playing position-specific effects and differences in kicking volumes and kick types.

Methods: Fifteen seasons of injury surveillance data and two seasons of match kicking characteristics from professional rugby players were analysed. Read More

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http://dx.doi.org/10.1111/sms.13737DOI Listing

FTICR-MS for the analysis of molecular composition and batch-to-batch consistency of plant derived polyphenolic ligand developed for biomedical application.

Rapid Commun Mass Spectrom 2020 Jun 3. Epub 2020 Jun 3.

Skolkovo Institute of Science and Technology, 143025, Skolkovo, Moscow region, Russia.

Rationale: Complex plant-derived polyphenols are promising for biomedical application. Their high complexity prevents the use of conventional pharmacopoeia techniques to perform quality control. The goal of this study was to apply ultra-high-resolution mass spectrometry to evaluate the batch-to-batch consistency of the molecular composition of a polyphenolic ligand using appropriate statistical metrics. Read More

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http://dx.doi.org/10.1002/rcm.8850DOI Listing

Cladribine modifies functional properties of microglia.

Clin Exp Immunol 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, Odense University Hospital, Odense, Denmark.

Background: Cladribine (CdA), an oral prodrug approved for the treatment of relapsing multiple sclerosis, selectively depletes lymphocytes. CdA passes the blood-brain barrier suggesting a potential effect on CNS resident cells.

Objective: We examined, if CdA modifies the phenotype and function of naïve and activated primary mouse microglia, when applied in the concentrations 0. Read More

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http://dx.doi.org/10.1111/cei.13473DOI Listing

Correlia: an ImageJ plug-in to co-register and visualise multi-modal correlative micrographs.

J Microsc 2020 Jun 3. Epub 2020 Jun 3.

Department of Isotope Biogeochemistry, Helmholtz Centre for Environmental Research (UFZ), Leipzig, 04318, Germany.

The correlation of different microscopic imaging techniques alongside with microanalytical methods is crucial to better understand biological processes on a sub-cellular level. For that, micrographs and chemical maps exhibiting both, very different spatial resolution and field-of-view but also a highly multi-modal content have to be co-registered. We developed the ImageJ/Fiji plug-in Correlia that provides an environment for handling multi-modal correlative microscopy data. Read More

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http://dx.doi.org/10.1111/jmi.12928DOI Listing

Semi-rational engineering of an amino acid racemase that is stabilized in aqueous/organic solvent mixtures.

Biotechnol Bioeng 2020 Jun 3. Epub 2020 Jun 3.

ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, 4058, Basel, Switzerland.

Enzymes are industrially applied under increasingly diverse environmental conditions that are dictated by efforts to optimize overall process efficiency. Engineering the operational stability of biocatalysts to enhance their half-lives under the desired process conditions is a widely applied strategy to reduce costs. Here, we present a simple method to enhance enzyme stability in the presence of monophasic aqueous/organic solvent mixtures based on the concept of strengthening the enzyme's surface hydrogen-bond network by exchanging surface-located amino acid residues for arginine. Read More

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http://dx.doi.org/10.1002/bit.27449DOI Listing

Unipept CLI 2.0: adding support for visualisations and functional annotations.

Bioinformatics 2020 Jun 3. Epub 2020 Jun 3.

Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.

Summary: Unipept is an ecosystem of tools developed for fast metaproteomics data-analysis consisting of a web application, a set of web services (API) and a command-line tool (CLI). After the successful introduction of version 4 of the Unipept web application, we here introduce version 2.0 of the API and CLI. Read More

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http://dx.doi.org/10.1093/bioinformatics/btaa553DOI Listing

Effect of Gastric Bypass vs Best Medical Treatment on Early-Stage Chronic Kidney Disease in Patients With Type 2 Diabetes and Obesity: A Randomized Clinical Trial.

JAMA Surg 2020 Jun 3:e200420. Epub 2020 Jun 3.

Diabetes Complications Research Center, UCD Conway Institute, University College Dublin School of Medicine, Dublin, Ireland.

Importance: Early-stage chronic kidney disease (CKD) characterized by microalbuminuria is associated with future cardiovascular events, progression toward end-stage renal disease, and early mortality in patients with type 2 diabetes.

Objective: To compare the albuminuria-lowering effects of Roux-en-Y gastric bypass (RYGB) surgery vs best medical treatment in patients with early-stage CKD, type 2 diabetes, and obesity.

Design, Setting, And Participants: For this randomized clinical trial, patients with established type 2 diabetes and microalbuminuria were recruited from a single center from April 1, 2013, through March 31, 2016, with a 5-year follow-up, including prespecified intermediate analysis at 24-month follow-up. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.0420DOI Listing
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