957,041 results match your criteria Applied Physics A-materials Science & Processing[Journal]


Resilience in the midst of chaos: Socioecological model applied to women with depressive symptoms and socioeconomic disadvantage.

J Community Psychol 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatry, University of Rochester School of Medicine, Rochester, New York.

Socioeconomic disadvantage is extremely common among women with depressive symptoms presenting for women's health care. While social stressors related to socioeconomic disadvantage can contribute to depression, health care tends to focus on patients' symptoms in isolation of context. Health care providers may be more effective by addressing issues related to socioeconomic disadvantage. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcop.22188
Publisher Site
http://dx.doi.org/10.1002/jcop.22188DOI Listing
April 2019
1 Read

Effect of Homeopathic Medicines on Intestinal Coccidia and Immune Response Cells in Spotted Rose Snapper (Lutjanus guttatus).

Homeopathy 2019 Apr 18. Epub 2019 Apr 18.

Centro de Investigaciones Biológicas del Noroeste S. C. (CIBNOR), La Paz, México.

Background:  Homeopathy has been widely applied in freshwater species but rarely in marine fish. Farm stress destabilises host-pathogen equilibrium, favouring parasites and disease. Coccidian endoparasites cause intestinal infections and cell degeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1681062DOI Listing

[Botulinumtoxin in Ophthalmology].

Authors:
Bettina Wabbels

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

Botulinum toxin has been first applied in ophthalmology (as treatment for strabismus) and is nowadays widely used in many clinical areas. Currently the main application in ophthalmology is the treatment of essential blepharospasm and hemifacial spasm. Other important indications for botulinum toxin in ophthalmology are eyelid retraction in Graves' disease and the induction of protective ptosis in lagophthalmos or corneal diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0885-2107DOI Listing

Comparing Three Different Contrast Sensitivity Tests in Adults and in Children with and without Amblyopia.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):434-437. Epub 2019 Apr 18.

University Eye Hospital Basel, Basel, Switzerland.

Background: Tests of contrast sensitivity (CS) are not routinely performed in the clinic, although CS is reduced in many conditions, such as amblyopia or glaucoma. This may be due to perceived time constraints or unaffordability of equipment.

Patients And Methods: Monocular CS functions obtained with the FACT, CSV 1000E, and Lea Symbols were compared in 19 healthy subjects aged 24 - 78 years and 24 subjects aged 5 - 16 years, 9 of whom had amblyopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0853-1683DOI Listing

How Effective Is Retrograde Semirigid and Flexible Ureteroscopic Lithotripsy for the Treatment of Large Ureteral Stones Equal of or Greater than 15 mm? Results from a Single Center.

Urol Int 2019 Apr 18:1-7. Epub 2019 Apr 18.

Department of Urology, General Hospital of Volos "Achillopouleio", Volos, Magnesia, Greece.

Purpose: To present the results and complications of retrograde ureteroscopic lithotripsy for treatment of large ureteral stones.

Methods: Nineteen patients were treated for ureteral stones ≥15 mm detected in CT or plain KUB film. Endoscopy was performed with either a semirigid or flexible ureteroscope. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499573DOI Listing

Physics-based spectral compensation algorithm for X-ray CT with primary modulator.

Phys Med Biol 2019 Apr 18. Epub 2019 Apr 18.

Advanced Therapies, Siemens Healthineers, Forchheim, GERMANY.

X-ray computed tomography (CT) scatter correction using primary modulator has been continuously developed over the past years, with progress in improving the performance of scatter correction. In this work, we further advance the primary modulator technique towards practical applications where the spectral nonuniformity caused by the modulator continues to be a challenging problem. A physics-based spectral compensation algorithm is proposed to adaptively correct for the spectral nonuniformity, and hence to reduce the resultant ring artifacts on reconstructed CT images. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6560/ab1ad0
Publisher Site
http://dx.doi.org/10.1088/1361-6560/ab1ad0DOI Listing
April 2019
1 Read

Cutaneous perfusion of the human lactating breast: a pilot study with laser Doppler perfusion monitoring.

Physiol Meas 2019 Apr 18. Epub 2019 Apr 18.

Biomedical Photonic Imaging, University of Twente, Drienerlolaan 5, building Zuidhorst 256, Enschede, Overijssel, 7500AE, NETHERLANDS.

<i>Objective</i>: Knowledge on the hemodynamics of the human lactating breast contributes to our understanding of lactation physiology, as well as the development and management of breastfeeding problems. The objective of this pilot study was to investigate whether laser Doppler perfusion monitoring (LDPM) can be employed to measure physiological changes in mammary cutaneous perfusion during milk extraction. <i>Approach</i>: We evaluated mammary cutaneous perfusion with LDPM in 9 lactating women during milk extraction in both the ipsilateral ('milk extracting') and contralateral ('passive') breast. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6579/ab1ad7DOI Listing

Low-dose radiation: interagency collaboration on planning research could improve information on health effects.

J Radiol Prot 2019 Apr 18. Epub 2019 Apr 18.

US Government Accountability Office, Washington, District of Columbia, UNITED STATES.

In September 2017, the U.S. Government Accountability Office (GAO) issued a report on the scientific basis for federal protections against the harmful effects of ionizing radiation-particularly low-dose radiation, or below about 100 millisieverts (10 rem). Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6498/ab1ada
Publisher Site
http://dx.doi.org/10.1088/1361-6498/ab1adaDOI Listing
April 2019
1 Read

Prognostic role of GPER/Ezrin in triple negative breast cancer is associated with menopausal status.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

T Wang, Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

The role of G protein-coupled estrogen receptor 1 (GPER) signaling including promoting Ezrin phosphorylation, which could be also activated by estrogen has not yet been clearly identified in triple negative breast cancer (TNBC). This study is to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Clinico-pathologic features including age, menopausal status, tumor size, nuclear grade, lymph node metastasis, AJCC TNM stage and ER, PR, HER-2 expression were evaluated from 249 TNBC cases. Read More

View Article

Download full-text PDF

Source
https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-016
Publisher Site
http://dx.doi.org/10.1530/EC-19-0164DOI Listing
April 2019
1 Read

Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing

Thermo-ecological analysis of industrial kilns.

J Environ Manage 2019 Apr 15;241:149-155. Epub 2019 Apr 15.

Department of Mechanical Engineering, Faculty of Engineering, Usak University, 64200, Usak, Turkey. Electronic address:

In this study, thermo-ecological analysis has been applied by using ecologic objective function "ECO" and ecological coefficient of performance "ECOP" to the kilns used in the firing process of the ceramic plant. Five different environmental (dead state) temperatures (between 10 °C and 30 °C) are taken into account. The irreversibility, which are the most important criteria affecting ecological performance, occurs during the heat transfer in the burners and cooling in the kiln. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.04.032DOI Listing

Activated carbon fiber for adsorption/electrodeposition of Cu (II) and the recovery of Cu (0) by controlling the applied voltage during membrane capacitive deionization.

J Colloid Interface Sci 2019 Apr 10;548:160-169. Epub 2019 Apr 10.

Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes, Hohai University, Nanjing 210098, China; College of Environment, Hohai University, Nanjing 210098, China.

Membrane capacitive deionization (MCDI) as a promising approach was developed to simultaneously conduct water desalination and metal recovery by using activated carbon fiber (ACF) as electrodes. The removal performance of two metal ions (Cu, Zn) was firstly investigated at different voltages. Experiments showed that the adsorption amount of Cu was higher than that of Zn under the voltage of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2019.04.030DOI Listing

De novo glycan structural identification from mass spectra using tree merging strategy.

Comput Biol Chem 2019 Mar 30;80:217-224. Epub 2019 Mar 30.

Key Lab of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Motivation: Glycans are large molecules with specific tree structures. Glycans play important roles in a great variety of biological processes. These roles are primarily determined by the fine details of their structures, making glycan structural identification highly desirable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiolchem.2019.03.015DOI Listing

Sampling and multiplexing in lab-on-paper bioelectroanalytical devices for glucose determination.

Biosens Bioelectron 2019 Apr 5;135:64-70. Epub 2019 Apr 5.

Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, 33006, Oviedo, Spain. Electronic address:

In this work, we present a multiplexed (eight simultaneous measurements) paper-based electrochemical device developed in a very simple way and using low-cost materials, such as paper, carbon ink and multifunctional connector headers. Meanwhile, we have also combined the paper-based electrochemical platform with a glass-fiber strip in order to integrate easily a sampling step. Both approaches, simultaneous measuring and sampling, have been applied to the determination of glucose using bienzymatic biosensors. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
Publisher Site
http://dx.doi.org/10.1016/j.bios.2019.04.006DOI Listing
April 2019
1 Read

Application of conducting polymers to wound care and skin tissue engineering: A review.

Biosens Bioelectron 2019 Apr 6;135:50-63. Epub 2019 Apr 6.

Nanyang Environment and Water Research Institute, Residues and Resource Reclamation Center, 1 Cleantech Loop, CleanTech, Singapore, 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore. Electronic address:

The use of intrinsically conducting polymers (CPs) in wound care and skin tissue engineering presents a novel opportunity for accelerated wound healing, enhanced antibacterial activity and the potential for controlled drug delivery. Through their increased electrical conductivity, CPs can facilitate the application of electrical stimulation directly to the wound area, which has been linked to faster wound healing. The release of drugs or biological agents to the wound site can likewise be modulated through the use of an external electrical stimuli. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
Publisher Site
http://dx.doi.org/10.1016/j.bios.2019.04.001DOI Listing
April 2019
1 Read

A method for the cell-cycle-specific analysis of radiation-induced chromosome aberrations and breaks.

Mutat Res 2019 Apr 6;815:10-19. Epub 2019 Apr 6.

Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, Essen, Germany. Electronic address:

The classical G-assay is widely used to assess cell-radiosensitivity and cancer phenotype: Cells are exposed to low doses of ionizing-radiation (IR) and collected for cytogenetic- analysis ˜1.5 h later. In this way, chromosome-damage is measured in cells irradiated in G-phase, without retrieving information regarding kinetics of chromosome-break-repair. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00275107193003
Publisher Site
http://dx.doi.org/10.1016/j.mrfmmm.2019.04.001DOI Listing
April 2019
1 Read

Experimental and theoretical insights on the effect of solvent polarity on the photophysical properties of a benzanthrone dye.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 3;218:221-228. Epub 2019 Apr 3.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Benzanthrone derivatives show interesting solvent dependent photophysical properties. Understanding of their photophysical properties is essential for developing the fluorescence probes based on benzanthrone derivatives. The photophysical properties of 3-(N'-chlorophenyl)piperazino-7H-benzo[de]anthracen-7-one [ClPh-PBA] molecule are reported in different solvents and solvent mixtures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2019.04.001DOI Listing

Mediation of functional gene and bacterial community profiles in the sediments of eutrophic Chaohu Lake by total nitrogen and season.

Environ Pollut 2019 Apr 10;250:233-240. Epub 2019 Apr 10.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science & Technology of China, Hefei, 230026, China. Electronic address:

Microbes in sediments contribute to nutrient release and play an important role in lake eutrophication. However, information about the profiles of functional genes and bacterial communities and the most important environmental factor affecting them in the sediments of eutrophic lake remains unrevealed. In this work, the real-time fluorescent quantitative polymerase chain reaction (qPCR) assay and 16S ribosomal RNA gene next generation sequencing analysis were used to explore the profiles of functional genes and bacterial communities in the sediments of Chaohu Lake. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.04.028DOI Listing

Immobilization of recombinant Escherichia coli whole cells harboring xylose reductase and glucose dehydrogenase for xylitol production from xylose mother liquor.

Bioresour Technol 2019 Apr 13;285:121344. Epub 2019 Apr 13.

Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China; Engineering Research Center of Bioconversion and Biopurification of Ministry of Education, Zhejiang University of Technology, Hangzhou 310014, PR China.

In this study, recombinant E. coli BL21(DE3)/pCDFDuet-1-XR-GDH harboring xylose reductase (XR) and glucose dehydrogenase (GDH) were immobilized and applied for the production of xylitol from xylose mother liquor (XML). Various immobilization methods were screened and the cross-linking approach with diatomite and polyetherimide as the raw materials and glutaraldehyde as the cross-linking agent was the optimal one, and the recovery activity reached of 80. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09608524193056
Publisher Site
http://dx.doi.org/10.1016/j.biortech.2019.121344DOI Listing
April 2019
1 Read

Male workers' exposure characteristics of ΣPCDD/F from a municipal solid waste incinerator in south China through hair analysis.

Ecotoxicol Environ Saf 2019 Apr 15;178:105-112. Epub 2019 Apr 15.

South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou, 510000, China. Electronic address:

Human hair, flue gas and fly ash from a municipal solid waste incinerator (MSWI) in south China were collected and analyzed for polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF). The ΣPCDD/F level in hair from male workers were higher than those from residents. The Principal Component Analysis (PCA) suggested that ΣPCDD/F in flue gas is an external source of male workers' hair ΣPCDD/F. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.04.011DOI Listing

Polycyclic aromatic hydrocarbons (PAHs) formation during the fast pyrolysis of hazardous health-care waste.

Chemosphere 2019 Apr 5;227:277-288. Epub 2019 Apr 5.

Farayand Sabz Pakan Co., Tehran, Iran. Electronic address:

Health-care waste management is a challenge for the health sector. Currently, pyrolysis technologies are being used to treat medical waste that can convert it to a hydrocarbon fuel. In the present study, hazardous health-care waste was pyrolyzed using a continuous tubular fast pyrolysis reactor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.04.028DOI Listing

Environmental impacts of dietary quality improvement in China.

J Environ Manage 2019 Apr 15;240:518-526. Epub 2019 Apr 15.

Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, 100084, China.

Dietary-related risks rank top among all the health risks in many countries. The 2nd United Nations Sustainable Development Goal aims to end hunger, achieve food security and improved nutrition and promote sustainable agriculture. Yet whether improving nutritional quality also benefits the environment is still under-explored, particularly for developing countries. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03014797193041
Publisher Site
http://dx.doi.org/10.1016/j.jenvman.2019.03.106DOI Listing
April 2019
1 Read

Porous iron material for TcO- and ReO- sequestration from groundwater under ambient oxic conditions.

J Hazard Mater 2019 Apr 9;374:177-185. Epub 2019 Apr 9.

Hӧganäs Environmental Solutions LLC, Cary, NC, 27513, USA.

Technetium-99 (Tc) is a major contaminant at nuclear power plants and several US Department of Energy sites. Its most common aqueous species, pertechnetate (TcO), is very mobile in the environment, and currently there are no effective technologies for its sequestration. In this work, a porous iron (pFe) material was investigated for TcO and perrhenate (ReO) sequestration from artificial groundwater. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043894193045
Publisher Site
http://dx.doi.org/10.1016/j.jhazmat.2019.04.030DOI Listing
April 2019
2 Reads

Enhanced superoxide sensitivity in organic field-effect transistor sensors by introducing nanoclay-polyphenol-polymer hybrid sensing channels.

J Hazard Mater 2019 Apr 2;374:159-166. Epub 2019 Apr 2.

Organic Nanoelectronics Laboratory and KNU Institute for Nanophotonics Applications (KINPA), Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, Daegu, 41566, Republic of Korea. Electronic address:

Here we report that nanoclay-polyphenol-polymer hybrid sensing channels can greatly enhance the sensitivity for hazardous reactive oxygen species (ROS) in organic field-effect transistor (OFET) sensors. The hybrid layers were prepared by introducing nanoclay into the binary mixtures of poly(3-hexylthiophene) (P3HT) and rutin (a polyphenol) at various weight ratios. The presence of nanoclay improved the P3HT crystallinity in the hybrid films, which contributed to the increased drain current and well-maintained hole mobility even at the reduced amount of charge-transporting P3HT part. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2019.04.013DOI Listing

In-vitro blood and vascular compatibility of sirolimus-eluting organic/inorganic hybrid stent coatings.

Colloids Surf B Biointerfaces 2019 Apr 9;179:405-413. Epub 2019 Apr 9.

Research Institute of Advanced Manufacturing Technology, Korea Institute of Industrial Technology, Incheon, 21999, Republic of Korea. Electronic address:

The surface characteristics of coronary stents play a pivotal role in inhibiting in-stent restenosis and late-stent thrombosis. In this study, a sol-gel-derived silica xerogel-chitosan hybrid coating was applied to Co-Cr stent and was reported, for the first time, as a biocompatible drug delivery tool in vascular stent application. A dense and uniform chitosan-silica xerogel hybrid coating (<1-μm thick) was applied on bare Co-Cr material. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.colsurfb.2019.04.018DOI Listing

A life cycle scenario analysis of different pavement technologies for urban roads.

Sci Total Environ 2019 Apr 5;673:585-593. Epub 2019 Apr 5.

University Mediterranea of Reggio Calabria, Department of Information, Infrastructure and Sustainable Energy (DIIES), Via Graziella, Feo di Vito, 89214 Reggio Calabria, Italy.

In the past, lowest price was the award criterion, given that structural capacity and safety were assured. In the last years, environmental, energy, and long-term impacts have been introduced (climate change, resource depletion, energy consumption, generated solid waste, discharged water, and emissions). Unfortunately, the introduction of new pavement technologies and materials (i. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697193156
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2019.04.046DOI Listing
April 2019
1 Read

The ventricular fibrillation waveform in relation to shock success in early vs. late phases of out-of-hospital resuscitation.

Resuscitation 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

Background: The amplitude spectrum area (AMSA) of the ventricular fibrillation (VF) waveform predicts shock success and clinical outcome after out-of-hospital cardiac arrest (OHCA). Recently, also AMSA-changes demonstrated prognostic value. Until now, most studies focused on early shocks, while many patients require prolonged resuscitations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.resuscitation.2019.04.010DOI Listing

The olfactory bulb proteotype differs across frontotemporal dementia spectrum.

J Proteomics 2019 Apr 15. Epub 2019 Apr 15.

Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Irunlarrea, 3, 31008 Pamplona, Spain; Proteored-ISCIII, Proteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain, Irunlarrea 3, 31008 Pamplona, Spain. Electronic address:

Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD-TDP43) subjects respect to elderly non-FTD group. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S18743919193011
Publisher Site
http://dx.doi.org/10.1016/j.jprot.2019.04.011DOI Listing
April 2019
1 Read

Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform.

J Pharmacol Toxicol Methods 2019 Apr 15. Epub 2019 Apr 15.

Drug Safety Research and Development, Pfizer Inc., La Jolla, CA 92121, United States of America.

Introduction: High throughput in vitro profiling of the cardiac Nav1.5 peak sodium current (I) is widely used in cardiac safety screening. However, there is no standardized high throughput method to measure late I. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vascn.2019.04.001DOI Listing

Transcriptome signatures of the Pacific white shrimp Litopenaeus vannamei hepatopancreas in response to stress in biofloc culture systems.

Fish Shellfish Immunol 2019 Apr 15. Epub 2019 Apr 15.

The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, 266003, People's Republic of China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266235, China.

Comparative transcriptome analysis via high throughput sequencing was applied to gain knowledge on the immune response in Litopenaeus vannamei reared in biofloc technology systems (BFT). Two types of carbon sources, namely, traditional carbon sources (molasses) and biodegradable polymers [hydroxybutyric acid-co-3-hydroxyvaleric acid (PHBV)] were used in BFT systems. Clear water systems without the addition of carbon sources were treated as the control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fsi.2019.04.043DOI Listing

Reconciling the controversial data on the effects of C fullerene at the organismal and molecular levels using as a model Drosophila melanogaster.

Toxicol Lett 2019 Apr 15. Epub 2019 Apr 15.

Taras Shevchenko National University of Kyiv, Volodymyrska St., 64, 01601, Kyiv, Ukraine.

Fullerenes have attracted attention since their discovery as structural units of complex carbon nanostructures capable of transporting drugs and macromolecules. As such artificial nanomaterials are applied in biology and medicine, they are routinely scrutinized for their effects on living organisms. The results of such studies range from direct destabilizing effects on DNA molecules to amelioration of the toxic effects of known genotoxic agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.toxlet.2019.03.006DOI Listing

Functional Connectivity Pattern in the Core Face Network Reflects Different Mechanisms of Holistic Face Processing Measured by the Whole-Part Effect and Composite-Face Effect.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing 100875, China.

Holistic face processing is a critical component of face recognition. There are two classical measures of holistic face processing: the whole-part effect (WPE) and composite-face effect (CFE). However, the two effects have demonstrated inconsistent pattern of results in behavioral literature. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03064522193025
Publisher Site
http://dx.doi.org/10.1016/j.neuroscience.2019.04.017DOI Listing
April 2019
1 Read

Conditioned Pain Modulation Affects the Withdrawal Reflex Pattern to Nociceptive Stimulation in Humans.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Integrative Neuroscience, SMI®, Dept. of Health Science and Technology, Fredrik Bajers Vej 7, Aalborg, Ø, (9220, ), Aalborg, Denmark; Center for Neuroplasticity and Pain (CNAP), SMI®, Dept. of Health Science and Technology, Fredrik Bajers Vej 7, Aalborg, Ø, (9220, ), Aalborg, Denmark. Electronic address:

Human studies have repeatedly shown that conditioning pain modulation (CPM) exerts an overall descending inhibitory effect over spinal nociceptive activity. Previous studies have reported a reduction of the nociceptive withdrawal reflex (NWR) under CPM. Still, how descending control influences the muscle activation patterns involved in this protective behavior remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroscience.2019.04.016DOI Listing

Gene editing-mediated disruption of epidermolytic ichthyosis-associated KRT10 alleles restores filament stability in keratinocytes.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

EB House Austria, Research Program for Molecular Therapy of Genodermatoses, Department of Dermatology, University Hospital of the Paracelsus Medical University Salzburg, Austria. Electronic address:

Epidermolytic ichthyosis (EI) is a skin fragility disorder caused by dominant-negative mutations in KRT1 or KRT10. No definitive restorative therapies exist that target these genetic faults. Gene editing can be used to efficiently introduce frameshift mutations to inactivate mutant genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.03.1146DOI Listing

The assembly and evaluation of antisense oligonucleotides applied in exon skipping for titin-based mutations in dilated cardiomyopathy.

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology and Cardiovascular Diseases, Eberhard Karls University, Tübingen, Germany; Department of Cardiology, RWTH Aachen, Pauwelsstr. 30, Aachen, Germany. Electronic address:

The leading cause of genetic dilated cardiomyopathy (DCM) is due to mutations in the TTN gene, impacting approximately 15-20% of familial and 18% of sporadic DCM cases. Currently, there is potential for a personalized RNA-based therapeutic approach in titin-based DCM, utilizing antisense oligonucleotide (AON) mediated exon-skipping, which attempts to reframe mutated titin transcripts, resulting in shortened, functional protein. However, the TTN gene is massive with 363 exons; each newly identified TTN exon mutation provides a challenge to address when considering the potential application of AON mediated exon skipping. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00222828193003
Publisher Site
http://dx.doi.org/10.1016/j.yjmcc.2019.04.014DOI Listing
April 2019
1 Read

Improvement of soluble expression of GM-CSF in the cytoplasm of Escherichia coli using chemical and molecular chaperones.

Protein Expr Purif 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmaceutical Biotechnology, Isfahan Pharmaceutical Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

The most common approaches to improve soluble expression of heterologous proteins are applications of molecular chaperones such as DnaK, DnaJ, GrpE, GroEL and GroES. The aim of present study was to enhance soluble expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in Escherichia coli by different approaches including modification of cultivation and induction conditions, and thermally, genetically and chemically enhancement of expression of cellular chaperones. To genetically enhance amount of molecular chaperones, co-expression of pET28-GM-CSF and pKJE7 plasmids was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pep.2019.04.002DOI Listing

Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Cardiovascular Disease.

J Obstet Gynecol Neonatal Nurs 2019 Apr 15. Epub 2019 Apr 15.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from cardiovascular disease (CVD) by the California Pregnancy-Associated Mortality Review committee.

Design: Qualitative descriptive design using thematic analysis.

Sample: A total of 269 QIOs identified from 87 pregnancy-related deaths from CVD in California from 2002 to 2007. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogn.2019.03.001DOI Listing

Nurse-performed focused ultrasound in the emergency department: A systematic review.

Australas Emerg Care 2018 Nov 15;21(4):121-130. Epub 2018 Oct 15.

Prince of Wales Hospital Emergency Department, Barker Street, Sydney, Australia.

Aim: The objective of this systematic review was to examine the characteristics and diagnostic accuracy of focused ultrasonography performed by emergency nurses.

Background: Focused ultrasonography is a limited, real-time, goal-directed examination performed to answer specific clinical questions. Its use within the ED setting has increased rapidly over the past two decades. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.auec.2018.09.003DOI Listing
November 2018

A prospective evaluation of the 'C.O.A.C.H.E.D.' cognitive aid for emergency defibrillation.

Australas Emerg Care 2018 Aug 10;21(3):81-86. Epub 2018 Sep 10.

Sydney Medical School, University of Sydney, Sydney, Australia; Simulated Learning Environment for Clinical Training (SiLECT), Sydney, Australia.

Introduction: International guidelines recommend that interruptions to chest compressions are minimised during defibrillation. As a result, some resuscitation educators have adopted a more structured approach to defibrillation. One such approach is the 'C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.auec.2018.08.002DOI Listing
August 2018
1 Read

Association of Exercise and Swimming Goggles With Modulation of Cerebro-ocular Hemodynamics and Pressures in a Model of Spaceflight-Associated Neuro-ocular Syndrome.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Integrated Cardiovascular Exercise Physiology and Rehabilitation Laboratory, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington.

Importance: Astronauts on International Space Station missions demonstrate adverse neuro-ocular changes. Reversing a negative translaminar pressure gradient (TLPG) by modulating cerebral blood flow, decreasing intracranial pressure, or increasing intraocular pressure (IOP) has been proposed as potential intervention for spaceflight-associated neuro-ocular syndrome (SANS).

Objective: To examine whether exercise (resistance, moderate-intensity aerobic, and high-intensity aerobic) or artificially increasing IOP is associated with modulated cerebro-ocular hemodynamic and pressure changes during head-down tilt (HDT), an analogue of spaceflight, in healthy adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2019.0459DOI Listing

Signal peptide peptidase activity connects the unfolded protein response to plant defense suppression by Ustilago maydis.

PLoS Pathog 2019 Apr 18;15(4):e1007734. Epub 2019 Apr 18.

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Göttingen Center for Molecular Biosciences (GZMB), University of Göttingen, Göttingen, Germany.

The corn smut fungus Ustilago maydis requires the unfolded protein response (UPR) to maintain homeostasis of the endoplasmic reticulum (ER) during the biotrophic interaction with its host plant Zea mays (maize). Crosstalk between the UPR and pathways controlling pathogenic development is mediated by protein-protein interactions between the UPR regulator Cib1 and the developmental regulator Clp1. Cib1/Clp1 complex formation results in mutual modification of the connected regulatory networks thereby aligning fungal proliferation in planta, efficient effector secretion with increased ER stress tolerance and long-term UPR activation in planta. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007734DOI Listing

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.

PLoS Pathog 2019 Apr 18;15(4):e1007657. Epub 2019 Apr 18.

Biomedical and Life Sciences, Faculty of Health and Medicine, University of Lancaster, Lancaster, United Kingdom.

Helminths are highly prevalent metazoan parasites that infect over a billion of the world's population. Hosts have evolved numerous mechanisms to drive the expulsion of these parasites via Th2-driven immunity, but these responses must be tightly controlled to prevent equally devastating immunopathology. However, mechanisms that regulate this balance are still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007657DOI Listing

Phase space methods for non-linear analysis of pedalling forces in cycling.

PLoS One 2019 18;14(4):e0198914. Epub 2019 Apr 18.

Department of Human Movement Science and Health, Chemnitz University of Technology, Chemnitz, Germany.

Introduction: From the perspective of dynamic systems theory, stability and variability of biological signals are both understood as a functional adaptation to variable environmental conditions. In the present study, we examined whether this theoretical perspective is applicable to the pedalling movement in cycling. Non-linear measures were applied to analyse pedalling forces with varying levels of subjective load. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198914PLOS

How is your mind-set? Proof of concept for the measurement of the level of emotional development.

PLoS One 2019 18;14(4):e0215474. Epub 2019 Apr 18.

Freie Universität Berlin, Fakultät für Erziehungswissenschaft und Psychologie, AB Klinisch-Psychologische Intervention, Berlin, Germany.

Background: In persons with intellectual and developmental disabilities, not only cognitive brain functions, but also socio-emotional processing networks may be impaired. This study aims to validate the Scale of Emotional Development-Short (SED-S) to provide an instrument for the assessment of socio-emotional brain functions.

Method: The SED-S was applied in 160 children aged 0-12 years. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215474PLOS

In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine.

PLoS One 2019 18;14(4):e0215508. Epub 2019 Apr 18.

Department of Genetics and Molecular Biology, Bioinformatics and Computational Biology Laboratory, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil.

Brain-derived neurotrophic factor (BDNF) plays an important role in neurogenesis and synapse formation. The V66M is the most prevalent BDNF mutation in humans and impairs the function and distribution of BDNF. This mutation is related to several psychiatric disorders. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215508PLOS

Experimental investigations of a manually versus an electrically driven skull drill for bedside usage.

PLoS One 2019 18;14(4):e0215171. Epub 2019 Apr 18.

Department of Neurosurgery, University Hospital Knappschaftskrankenhaus Bochum, Ruhr-University Bochum, Bochum, Germany.

Background: Manual skull drilling is an old but in modern neurosurgery still established procedure which can be applied quickly and universally in emergency situations. Electrical drilling requires more complex equipment and is usually reserved to the Operating Room (OR). It also seems desirable to apply an electrical drill for bedside usage but a suitable product does not exist so far. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215171PLOS

Multi-trait multi-environment models in the genetic selection of segregating soybean progeny.

PLoS One 2019 18;14(4):e0215315. Epub 2019 Apr 18.

Federal University of Viçosa-Department of Plant Science, University Campus, Viçosa, Minas Gerais, Brazil.

At present, single-trait best linear unbiased prediction (BLUP) is the standard method for genetic selection in soybean. However, when genetic selection is performed based on two or more genetically correlated traits and these are analyzed individually, selection bias may arise. Under these conditions, considering the correlation structure between the evaluated traits may provide more-accurate genetic estimates for the evaluated parameters, even under environmental influences. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215315PLOS

Numerical simulations for the Toda lattices Hamiltonian system: Higher order symplectic illustrative perspective.

PLoS One 2019 18;14(4):e0215054. Epub 2019 Apr 18.

Department of Mathematics, School of Natural Sciences (SNS), National University of Sciences and Technology (NUST), Islamabad 44000, Pakistan.

In this paper we apply some higher order symplectic numerical methods to analyze the dynamics of 3-site Toda lattices (reduced to relative coordinates). We present benchmark numerical simulations that has been generated from the HOMsPY (Higher Order Methods in Python) library. These results provide detailed information of the underlying Hamiltonian system. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215054PLOS

Varicose veins of lower extremities: Insights from the first large-scale genetic study.

PLoS Genet 2019 Apr 18;15(4):e1008110. Epub 2019 Apr 18.

Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data of 408,455 European-ancestry individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1008110DOI Listing

Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients.

PLoS One 2019 18;14(4):e0214604. Epub 2019 Apr 18.

Ingham Institute for Applied Medical Research, Liverpool, NSW Australia.

Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses their significance on patient survival as a single or combined marker with P16 or P14 using breast cancer progression series. One thousand and eighty (1080) patients with primary invasive ductal carcinoma, no special type, were recruited through an 11-year retrospective study period. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214604PLOS
  • Page 1 of 19141