Appl Organomet Chem 2021 Oct 13:e6469. Epub 2021 Oct 13.
Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry S.E.T.'s College of Pharmacy Dharwad India.
Since 2019, the infection of SARS-CoV-2 has been spreading worldwide and caused potentially lethal health problems. In view of this, the present study explores the most commodious and environmentally benign synthetic protocol for the synthesis of tetrahydrobenzopyran and pyrano[2,3-]pyrimidinones as SARS-CoV-2 inhibitors via three-component cycloaddition of aromatic aldehyde, malononitrile, and dimedone/barbituric acid in water. Lemon peel from juice factory waste, namely, lemon (), sweet lemon (), and Kaffir lime or Citron (), effectually utilized to obtain WELPSA, WESLPSA, and WEKLPSA, respectively, for the synthesis of title compounds. Read More