7 results match your criteria Applied Organometallic Chemistry[Journal]

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Synthesis and characterization of two new mixed-ligand Cu(II) complexes of a tridentate NN'O type Schiff base ligand and N-donor heterocyclic co-ligands: In vitro anticancer assay, DNA/human leukemia/COVID-19 molecular docking studies, and pharmacophore modeling.

Appl Organomet Chem 2022 May 24;36(5):e6639. Epub 2022 Feb 24.

Department of Chemistry, North Tehran Branch Islamic Azad University Tehran Iran.

Two new mixed-ligand complexes with general formula [Cu(SB)(L')]ClO ( and ) were synthesized and characterized by different spectroscopic and analytical techniques including Fourier transform infrared (FT-IR) and UV-Vis spectroscopy and elemental analyses. The SB ligand is an unsymmetrical tridentate NN'O type Schiff base ligand that was derived from the condensation of 1,2-ethylenediamine and 5-bromo-2-hydroxy-3-nitrobenzaldehyde. The L' ligand is pyridine in () and 2,2'-dimethyl-4,4'-bithiazole () in (). Read More

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Experimental and theoretical study of novel amino-functionalized P(V) coordination compounds suggested as inhibitor of M of SARS-COV-2 by molecular docking study.

Appl Organomet Chem 2022 May 1;36(5):e6636. Epub 2022 Mar 1.

IEM Université de Montpellier, CNRS, ENSCM Montpellier France.

Amino-functionalized P(V) derivatives providing both - and -donor modes have attracted interest owing to their potential to form interesting coordination assemblies with applications such as biological drugs. Novel coordination modes of two- and four-dentate tris (pyridin-2-yl)phosphoric triamide OP[NH-Py] as ([Co{[O][NH-Py]P(O)[Ph]}(DMF)], ) and ([CuCl{[NH-Py]P(O)[N-Py]}].DMF, ) have been synthesized and structurally studied. Read More

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WELPSA: A natural catalyst of alkali and alkaline earth metals for the facile synthesis of tetrahydrobenzo[]pyrans and pyrano[2,3-]pyrimidinones as inhibitors of SARS-CoV-2.

Appl Organomet Chem 2021 Oct 13:e6469. Epub 2021 Oct 13.

Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry S.E.T.'s College of Pharmacy Dharwad India.

Since 2019, the infection of SARS-CoV-2 has been spreading worldwide and caused potentially lethal health problems. In view of this, the present study explores the most commodious and environmentally benign synthetic protocol for the synthesis of tetrahydrobenzo[]pyran and pyrano[2,3-]pyrimidinones as SARS-CoV-2 inhibitors via three-component cycloaddition of aromatic aldehyde, malononitrile, and dimedone/barbituric acid in water. Lemon peel from juice factory waste, namely, lemon (), sweet lemon (), and Kaffir lime or Citron (), effectually utilized to obtain WELPSA, WESLPSA, and WEKLPSA, respectively, for the synthesis of title compounds. Read More

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October 2021

Titanium (IV) complexes of some tetra-dentate symmetrical bis-Schiff bases of 1,6-hexanediamine: Synthesis, characterization, and in silico prediction of potential inhibitor against coronavirus (SARS-CoV-2).

Appl Organomet Chem 2020 Oct 19:e6067. Epub 2020 Oct 19.

UL Laboratories Dhaka Bangladesh.

Symmetrical bis-Schiff bases (LH ) have been synthesized by the condensation of 1,6-hexanediamine (hn) and carbonyl or dicarbonyl. One of the synthesized Schiff bases has been subjected to the molecular docking for the prediction of their potentiality against coronavirus (SARS-CoV-2). Molecular docking revealed that tested Schiff base possessed high binding affinity with the receptor protein of SARS CoV-2 compared with hydroxychloroquine (HCQ). Read More

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October 2020

Quantum dots as a promising agent to combat COVID-19.

Appl Organomet Chem 2020 Jun 26:e5887. Epub 2020 Jun 26.

Food Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management Alagappa University Karaikudi India 630003 India.

Approximately every 100 years, as witnessed in the last two centuries, we are facing an influenza pandemic, necessitating the need to combat a novel virus strain. As a result of the new coronavirus (severe acute respiratory syndrome coronavirus type 2 [SARS-CoV-2] outbreak in January 2020, many clinical studies are being carried out with the aim of combating or eradicating the disease altogether. However, so far, developing coronavirus disease 2019 (COVID-19) detection kits or vaccines has remained elusive. Read More

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Zr Labeled [email protected] Nanoparticles: Afffinities with Breast and Prostate Cancer Cells.

Appl Organomet Chem 2020 May 1;34(5). Epub 2020 Mar 1.

Memorial Sloan Kettering Cancer Center, Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA.

In this study, [email protected] nanoparticles were synthesized as a new Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) hybrid imaging agent and radiolabeled with Zr. In addition, FeO nanoparticles were synthesized and radiolabeled with Zr. Df-Bz-NCS was used as bifunctional ligand. Read More

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Spectroscopic and Thermal Characterization of the Host-Guest Interactions between α-, β-, and γ-cyclodextrins and vanadocene dichloride.

Appl Organomet Chem 2008 Jun;22(8):440-450

University of Puerto Rico, Department of Chemistry PO Box 9019 Mayaguez, PR 00681.

Host-guest interactions between α-, β-, and γ-cyclodextrins and vanadocene dichloride (Cp(2)VCl(2)) have been investigated by a combination of thermogravimetric analysis, differential scanning calorimeters, PXRD and solid state and solution EPR spectroscopy. The solid state results demonstrated that only β- and γ-cyclodextrins form 1:1 inclusion complexes, while α-cyclodextrin does not form an inclusion complex with Cp(2)VCl(2). The β- and γ-CD-Cp(2)VCl(2) inclusion complexes exhibited anisotropic electron-(51)V (I = 7/2) hyperfine coupling constants whereas the α-CD- Cp(2)VCl(2) system showed only an asymmetric peak with no anisotropic hyperfine constant. Read More

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