1,070,541 results match your criteria Applied Ocean Research[Journal]


Multifunctional silk coating on additively manufactured porous titanium to prevent implant-associated infection and stimulate bone regeneration.

Biomed Mater 2020 Jul 8. Epub 2020 Jul 8.

Orthopedie, Universitair Medisch Centrum Utrecht, Heidelberglaan 100, Utrecht, 3508 GA, NETHERLANDS.

Despite the tremendous progress in the design and manufacturing of metallic implants, they do not outlive the patients. To illustrate, more than half of hip replacements will fail mainly due to implant infection and loosening. Surface engineering approaches and, in particular, coatings would facilitate implant bio-functionality via recruitment of more host cells for new bone formation and inhibition of bacterial colonization. Read More

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http://dx.doi.org/10.1088/1748-605X/aba40bDOI Listing

Survey on Knowledge and Psychological Crisis Related to COVID-19 among Nursing Staff: A Cross-sectional Study.

JMIR Form Res 2020 Jul 7. Epub 2020 Jul 7.

Mianyang Central Hospotal, Mianyang, CN.

Background: Background: Since December 2019, the prevalence of COVID-19 is rapidly spreading in the world. Nurses play a key role in fighting this disease and are at risk of infection by coronavirus. Therefore, there is a urging need to assess their mental health condition and set up appropriate interventions to reduce the negative psychiatric outcomes. Read More

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http://dx.doi.org/10.2196/20606DOI Listing

Long Noncoding RNA HOXD-AS1 Promotes the Proliferation, Migration, and Invasion of Colorectal Cancer via the miR-526b-3p/CCND1 Axis.

J Surg Res 2020 Jul 5;255:525-535. Epub 2020 Jul 5.

Department of Oncology, the Third People's Hospital of Hubei Province, Wuhan, Hubei, China. Electronic address:

Background: Colorectal cancer (CRC) is one of the most common malignancies in the world. It has been reported that the abnormal expression of long noncoding RNA HOXD-AS1 promotes the development of CRC, while the mechanism is still unclear. The aim of this study is to investigate the effects of HOXD-AS1 on proliferation, migration, and invasion in CRC and explore the underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.jss.2020.05.078DOI Listing

To charge or to cap in agricultural water management. Insights from modular iterative modeling for the assessment of bilateral micro-macro-economic feedback links.

Sci Total Environ 2020 Jun 27;742:140526. Epub 2020 Jun 27.

Department of Economics and Economic History, Universidad de Salamanca, Spain.

This paper develops an iterative micro-macro-economic modeling framework to assess agricultural water management policies including feedbacks between local and economy-wide impacts. The main contribution of the paper is the introduction of a set of bidirectional protocols that work through land use and price changes to model the bilateral feedbacks between the micro and macro scales. The proposed framework is applied to the Castile and León Region in Spain, where we assess the performance of two alternative water conservation policies (charges and caps) and compare results to those obtained using a conventional stand-alone microeconomic model. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140526DOI Listing

Lethal and sub-lethal effects of environmentally relevant levels of imidacloprid pesticide to Eastern School Prawn, Metapenaeus macleayi.

Sci Total Environ 2020 Jun 23;742:140449. Epub 2020 Jun 23.

School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia; Port Stephens Fisheries Institute, New South Wales Department of Primary Industries, Locked Bag 1, Nelson Bay, New South Wales 2315, Australia.

Pesticides are frequently employed to enhance agricultural production. Neonicotinoid pesticides (including imidacloprid) are often used to control sucking insects but have been shown to impact aquatic crustaceans. Imidacloprid is highly water soluble and has been detected in estuaries where it has been applied in adjacent catchments. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140449DOI Listing

Temporal variations of short-term effects of particulate matter on hospital admissions in the most densely populated city in Thailand.

Sci Total Environ 2020 Jul 1;742:140651. Epub 2020 Jul 1.

Department of Environmental Health Sciences, Faculty of Public Health, Mahidol University, Bangkok, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Bangkok, Thailand.

Short-term effects of ambient particulate matter (PM) on daily hospital admissions have been comprehensively elucidated, but very few studies evaluated the temporal variations of ambient PM associated with hospital admissions, especially in developing countries. This study aimed to explore the temporal changes of the short-term effects of PM on hospital admissions in Bangkok, Thailand from 2006 to 2014. The overdispersed Poisson regression model was applied to related daily PM concentrations to daily cardiovascular and respiratory hospital admissions by adjusting for temperature, humidity, long-term trend and seasonality, day of the week, public holiday, and population dynamics. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140651DOI Listing

Functional CdS nanocomposites recovered from biomineralization treatment of sulfate wastewater and its applications in the perspective of photocatalysis and electrochemistry.

Sci Total Environ 2020 Jul 1;742:140646. Epub 2020 Jul 1.

Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan; Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.

The sulfur ions generated during the microbial treatment of sulfate wastewater could cause secondary pollution problem, however, the application of the biomineralization technique could convert sulfur ions into sulfide nanocomposites with diverse properties. This study constructed a multi-stage process for sulfate wastewater treatment and CdS nanocomposites (CdS-NCs) recovery by using biomineralization, which simultaneously achieved the removal of pollutants and recovery of functional nanocomposites. In this process, about 97% of the sulfate could be removed, and the CdS-NCs with a diameter of 16. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140646DOI Listing

Use of an in situ thermoelectric generator for electric field-assisted aerobic composting.

Sci Total Environ 2020 Jun 30;742:140618. Epub 2020 Jun 30.

Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Electric field-assisted aerobic composting (EAAC) is a simple and effective process. To further improve the EAAC process and make good use of waste heat during composting, in this study, we designed an in situ thermoelectric generator using thermoelectric sheets and applied it for EAAC. The findings show that the voltage generated was 8. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140618DOI Listing

PM spatial distribution and metals speciation study in the Bilbao metropolitan area during the 2017-2018 period.

Chemosphere 2020 Jul 1;259:127482. Epub 2020 Jul 1.

Department of Analytical Chemistry, Faculty of Science and Technology, University of the Basque Country UPV/EHU, P.O. Box 644, 48080, Bilbao, Basque Country, Spain.

Speciation of respirable particles is becoming increasingly important from an epidemiological and analytical point of view to determine the potential effects of air pollution on human health. For this reason, current laws and analytical sampling methods focus on particle size, as it turns out to be the main factor for the greater or lesser penetration into the airways. In this sense, particles of less than 10 μm in diameter (<10 μm), referred to as PM, are the particles that have a higher capacity for access to the respiratory tract and, therefore, more significant effect on them. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127482DOI Listing

Characterizing developmental prosopagnosia beyond face perception: Impaired recollection but intact familiarity recognition.

Cortex 2020 May 18;130:64-77. Epub 2020 May 18.

Boston Attention and Learning Laboratory, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address:

Converging lines of research suggests that many developmental prosopagnosics (DPs) have impairments beyond face perception, but currently no framework exists to characterize these impaired mechanisms. One potential extra-perceptual deficit is that DPs encode/retrieve faces in a distinct manner from controls that does not sufficiently support individuation. To test this possibility, 30 DPs and 30 matched controls performed an old/new face recognition task while providing confidence ratings, to which a model-based ROC analysis was applied. Read More

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http://dx.doi.org/10.1016/j.cortex.2020.04.016DOI Listing

Ensemble methods in combination with compartment models for blood glucose level prediction in type 1 diabetes mellitus.

Comput Methods Programs Biomed 2020 Jun 27;196:105628. Epub 2020 Jun 27.

FN Motol University Hospital, Prague, Czech Republic.

Backgroung: Type 1 diabetes is a disease that adversely affects the daily life of a large percentage of people worldwide. Daily glucose levels regulation and useful advices provided to patients regarding their diet are essential for diabetes treatment. For this reason, the interest of the academic community has focused on developing innovative systems, such as decision support systems, based on glucose prediction algorithms. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105628DOI Listing

Electron beam irradiation to reduce the mycotoxin and microbial contaminations of cereal-based products: an overview.

Food Chem Toxicol 2020 Jul 5:111557. Epub 2020 Jul 5.

Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas, SP, Brazil. Electronic address:

The contamination of food commodities in various conditions along the production chain is the point of concern, especially among recent years. While different conventional methods for microbial and mycotoxin decontamination of cereal and cereal-based products were introduced, approaching of newly introduced techniques such as Electron Beam Irradiation (EBI) attracted notable attention. EBI is classified as a non-thermal method for decontamination with several advantages over conventional thermal treatments, including environmental friendly, time effective, and lower detrimental effects on the nutritional value of food products. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111557DOI Listing

Corrigendum to "Protective effect of EX-527 against high-fat diet-induced diabetic nephropathy in Zucker rats" [Toxicology and Applied Pharmacology 390 (2020) 114899].

Toxicol Appl Pharmacol 2020 Jul 5:115128. Epub 2020 Jul 5.

School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 440-746, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2020.115128DOI Listing

SARS-CoV2 envelope protein: Non-synonymous mutations and its consequences.

Genomics 2020 Jul 5. Epub 2020 Jul 5.

Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India. Electronic address:

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 15 (0.414%) genomes among 3617 available SARS-CoV2 genomes. Read More

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http://dx.doi.org/10.1016/j.ygeno.2020.07.001DOI Listing

Screening of Pharmaceutical Polymers for Extrusion-Based Additive Manufacturing of Patient- Tailored Tablets.

Int J Pharm 2020 Jul 5:119591. Epub 2020 Jul 5.

Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium. Electronic address:

The main objective of this work was to explore the potential of coupling hot-melt extrusion (HME) to Fused Filament Fabrication (FFF), also known as Extrusion-Based Additive Manufacturing (EBAM) or 3D Printing, in order to manufacture 3D printed tablets with different release behavior from plasticizer-free filament matrices. The suitability of different thermoplastic polymers towards FFF was investigated, and a link between the mechanical properties of filaments produced by HME and the feeding performance into the FFF printer was established. Model drugs with different aqueous solubility (metoprolol tartrate and theophylline anhydrous) were processed with hydrophilic and hydrophobic polymers, and the influence of the formulation, drug concentration and applied process settings on the release kinetics was investigated. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119591DOI Listing

The Effect of Access Cavity Designs and Sizes of Root Canal Preparations on the Biomechanical Behavior of an Endodontically Treated Mandibular First Molar: A Finite Element Analysis.

J Endod 2020 Jul 5. Epub 2020 Jul 5.

Department of Conservative Dentistry, Pusan National University School of Dentistry, Dental Research Institute, Yangsan, Korea. Electronic address:

Introduction: This study aimed to compare the biomechanical properties of a mandibular first molar with different endodontic cavity designs and increasing sizes of root canal preparations using finite element analysis (FEA).

Methods: The experimental FE models were designed with three different endodontic access cavities and two sizes of canal preparations; traditional access cavity (TRD), conservative access cavity (CON), and truss access cavity (TUS), and #30/.04 and #40/. Read More

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http://dx.doi.org/10.1016/j.joen.2020.06.040DOI Listing

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells.

Immunity 2020 Jul 1. Epub 2020 Jul 1.

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Chiba, Japan; Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Only a small percentage of patients afflicted with gastric cancer (GC) respond to immune checkpoint blockade (ICB). To study the mechanisms underlying this resistance, we examined the immune landscape of GC. A subset of these tumors was characterized by high frequencies of regulatory T (Treg) cells and low numbers of effector T cells. Read More

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http://dx.doi.org/10.1016/j.immuni.2020.06.016DOI Listing

Side-by-side comparison of next-generation sequencing, cytology, and histology in diagnosing locally advanced pancreatic adenocarcinoma.

Gastrointest Endosc 2020 Jul 5. Epub 2020 Jul 5.

Department of Gastroenterology, Endoscopic Unit, Humanitas Clinical and Research Center- IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy; Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele - Milan, Italy.

Background And Aims: EUS-guided biopsy is the method of choice for obtaining pancreatic tissue. Next-generation sequencing (NGS) has been applied to EUS-guided biopsies and may classify patients based on specific molecular profiles. Our study aimed to compare side-by-side the diagnostic yield achievable by genetic identification of somatic mutations detected with NGS versus histological and cytological typing in locally advanced pancreatic carcinoma (LAPC) in samples acquired under EUS guidance. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.069DOI Listing

The influences of chokeberry extract supplementation on redox status and body composition in handball players during competition phase.

Can J Physiol Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Facuklty of Medical Sciences, University of Kragujevac, Department of Physiology , Svetozara arkovića 69 , Kragujevac, Serbia , 34000.

The aim of our study was to investigate the influence of twelve-week consumption of chokeberry extract on redox status, body composition, lipid profile and biochemical parameters in active handball players. The study included 16 handball players, aged 16-24 years (20.26±2. Read More

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http://dx.doi.org/10.1139/cjpp-2020-0095DOI Listing

Highly sensitive flexible piezoresistive sensor with 3D conductive network.

ACS Appl Mater Interfaces 2020 Jul 8. Epub 2020 Jul 8.

Flexible piezoresistive sensor has attracted more and more attention in health monitoring and man-machine interface due to its simple structure and convenient signal reading. Herein, a highly sensitive flexible piezoresistive sensor with 3D conductive sensing unit is presented. The 3D conductive sensing unit consists of 3D network thermoplastic elastomer (TPE) substrate fabricated by fused deposition molding (FDM) 3D printing and carbon nanotubes (CNTs) conductive layer embedded into the surface of the TPE substrate. Read More

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http://dx.doi.org/10.1021/acsami.0c09552DOI Listing

Core-Shell Fe-FeS Nanoparticles with Controlled Shell Thickness for Enhanced Trichloroethylene Removal.

ACS Appl Mater Interfaces 2020 Jul 8. Epub 2020 Jul 8.

Zero-valent iron nanoparticles (nZVI) treated by reduced sulfur compounds (i.e., sulfidated nZVI, S-nZVI) have attracted increased attention as a promising material for environmental remediation. Read More

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http://dx.doi.org/10.1021/acsami.0c08626DOI Listing

Base editing with high efficiency in allotetraploid oilseed rape by A3A-PBE base editing system.

Plant Biotechnol J 2020 Jul 8. Epub 2020 Jul 8.

Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Key Laboratory for Biological Sciences and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Wuhan, 430062, China.

CRISPR/Cas- base editing is an emerging technology that could convert a nucleotide to another type at the target site. In this study, A3A-PBE system consisting of human A3A cytidine deaminase fused with a Cas9 nickase and uracil glycosylase inhibitor, was established and developed in allotetraploid Brassica napus. We designed three sgRNAs to target ALS, RGA and IAA7 genes, respectively. Read More

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http://dx.doi.org/10.1111/pbi.13444DOI Listing

Accessing copper oxidation states of dissolved negative electrode current collectors in lithium ion batteries.

Electrophoresis 2020 Jul 8. Epub 2020 Jul 8.

University of Münster, MEET Battery Research Center, Institute of Physical Chemistry, Münster, Germany.

A novel capillary electrophoresis (CE) method with ultraviolet/visible spectroscopy (UV/Vis) detection for the investigation of dissolved Cu and Cu in lithium ion battery (LIB) electrolytes was developed. This method is of relevance, as the current collector at the anode of LIBs may dissolve under certain operation conditions. In order to preserve the actual oxidation states of dissolved copper in the electrolytes and to prevent any precipitation during sample preparation and CE measurements, neocuproine (NC) and ethylenediamine tetraacetic (EDTA) were effectively applied as complexing agents for both ionic copper species. Read More

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http://dx.doi.org/10.1002/elps.202000155DOI Listing

Enzyme-catalysed polymer cross-linking: Biocatalytic tools for chemical biology, materials science and beyond.

Biopolymers 2020 Jul 8:e23390. Epub 2020 Jul 8.

School of Biochemistry, University of Bristol, University Walk, Bristol, UK.

Intermolecular cross-linking is one of the most important techniques that can be used to fundamentally alter the material properties of a polymer. The introduction of covalent bonds between individual polymer chains creates 3D macromolecular assemblies with enhanced mechanical properties and greater chemical or thermal tolerances. In contrast to many chemical cross-linking reactions, which are the basis of thermoset plastics, enzyme catalysed processes offer a complimentary paradigm for the assembly of cross-linked polymer networks through their predictability and high levels of control. Read More

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http://dx.doi.org/10.1002/bip.23390DOI Listing

T-cell receptor therapy (TCR) against melanoma -immunotherapy for the future?

Scand J Immunol 2020 Jul 8:e12927. Epub 2020 Jul 8.

Department of Cellular Therapy, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Malignant melanoma has seen monumental changes in treatment-options the last decade from the very poor results of dacarbazine treatment to the modern-day use of targeted therapies and immune checkpoint inhibitors. Melanoma has a high mutational burden making it more capable of evoking immune responses than many other tumours. Even when considering double immune checkpoint blockade with anti-CTLA-4 and-PD-1 we still have far to go in melanoma treatment as 50% of patients with metastatic disease do not respond to current treatment. Read More

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http://dx.doi.org/10.1111/sji.12927DOI Listing

Actions, indicators, and outputs in urban biodiversity plans: A multinational analysis of city practice.

PLoS One 2020 8;15(7):e0235773. Epub 2020 Jul 8.

Department of Computing Science, University of Alberta, Edmonton, AB, Canada.

Urban biodiversity offers important benefits to residents and may be crucial to reaching global biodiversity conservation targets, but little research has been conducted on how cities actually plan for biodiversity. In this study, we conducted a mixed methods content analysis of biodiversity plans by 39 cities around the world to determine whether they measured their actions, how they did so (via quantitative indicators and qualitative outputs), and what topics these actions and measures covered. We based our analytical framework on the Singapore Index on Cities' Biodiversity (also known as the City Biodiversity Index), a widely applied 23-indicator index that helps cities track their progress in biodiversity planning. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235773PLOS

In silico guided structural and functional analysis of genes with potential involvement in resistance to coffee leaf rust: A functional marker based approach.

PLoS One 2020 8;15(7):e0222747. Epub 2020 Jul 8.

Laboratório de Biotecnologia do Cafeeiro (BIOCAFÉ), BIOAGRO, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil.

Physiology-based differentiation of SH genes and Hemileia vastatrix races is the principal method employed for the characterization of coffee leaf rust resistance. Based on the gene-for-gene theory, nine major rust resistance genes (SH1-9) have been proposed. However, these genes have not been characterized at the molecular level. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222747PLOS

A mini ROV-based method for recovering marine instruments at depth.

PLoS One 2020 8;15(7):e0235321. Epub 2020 Jul 8.

Fisheries and Aquatic Sciences, University of Florida, Gainesville, Florida, United States of America.

Instruments are often deployed at depth for weeks to years for a variety of marine applications. In many cases, divers can be deployed to retrieve instruments, but divers are constrained by depth limitations and safety concerns. Acoustic release technology can also be employed but can add considerable expense and acoustic releases will at times fail. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235321PLOS

Characterizing the postmortem human bone microbiome from surface-decomposed remains.

PLoS One 2020 8;15(7):e0218636. Epub 2020 Jul 8.

Department of Biosystems Engineering and Soil Science, University of Tennessee, Knoxville, Tennessee, United States of America.

Microbial colonization of bone is an important mechanism of postmortem skeletal degradation. However, the types and distributions of bone and tooth colonizing microbes are not well characterized. It is unknown if microbial communities vary in abundance or composition between bone element types, which could help explain differences in human DNA preservation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218636PLOS

Choosing between the UN's alternative views of population aging.

PLoS One 2020 8;15(7):e0233602. Epub 2020 Jul 8.

Wittgenstein Centre for Demography and Global Human Capital (Univ. Vienna, IIASA, VID/ÖAW), International Institute for Applied Systems Analysis, Laxenburg, Austria.

Commonly used measures of population aging categorize adults into those who are "old" and those who are not. How this threshold of the stage of "old age" is determined is crucial for our understanding of population aging. We propose that the old age threshold be determined using an equivalency criterion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233602PLOS

Age-related change in flicker thresholds with rod- and cone-enhanced stimuli.

PLoS One 2020 8;15(7):e0232784. Epub 2020 Jul 8.

Centre for Applied Vision Research, School of Health Sciences, City, University of London, London, England, United Kingdom.

Purpose: Rod and cone photoreceptor-specific tests can be time-consuming. A new non-invasive test is described. The test is based on the measurement of flicker modulation thresholds with rod- and cone-enhanced visual stimuli, which requires only minimum adaptation time. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232784PLOS

Evaluation of Omics-Based Strategies for the Management of Advanced Lung Cancer.

JCO Oncol Pract 2020 Jul 8:OP2000117. Epub 2020 Jul 8.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.

Purpose: Omic-informed therapy is being used more frequently for patients with non-small-cell lung cancer (NSCLC) being treated on the basis of evidence-based decision-making. However, there is a lack of a standardized framework to evaluate those decisions and understand the association between omics-based management strategies and survival among patients. Therefore, we compared outcomes between patients with lung adenocarcinoma who received omics-driven targeted therapy versus patients who received standard therapeutic options. Read More

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http://dx.doi.org/10.1200/OP.20.00117DOI Listing

Do we need empirical research on the use of trolley dilemmas in applied ethics? Reply to commentary by Heidi Matisonn.

J Empir Res Hum Res Ethics 2020 Jul 8:1556264620939805. Epub 2020 Jul 8.

Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

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http://dx.doi.org/10.1177/1556264620939805DOI Listing

Methods for Model Calibration under High Uncertainty: Modeling Cholera in Bangladesh.

Med Decis Making 2020 Jul 8:272989X20938683. Epub 2020 Jul 8.

Center for Health Policy and Center for Primary Care & Outcomes Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA (TR, DKO, EB, JDG-F).

Published data on a disease do not always correspond directly to the parameters needed to simulate natural history. Several calibration methods have been applied to computer-based disease models to extract needed parameters that make a model's output consistent with available data. To assess 3 calibration methods and evaluate their performance in a real-world application. Read More

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http://dx.doi.org/10.1177/0272989X20938683DOI Listing

Interrelationship of Posttraumatic Stress, Hassles, Uplifts, and Coping in Women With a History of Severe Sexual Abuse: A Cross-Sectional Study.

J Interpers Violence 2020 Jul 8:886260520935479. Epub 2020 Jul 8.

Inland Norway University of Applied Sciences, Elverum, Norway.

Experiencing trauma, such as sexual abuse, increases the risk of a negative health outcome. The aim of the present study was to compare two groups of female survivors of sexual abuse, one group with a lower indication of posttraumatic stress disorder (L-PTSD) and one with a higher indication of posttraumatic stress disorder (H-PTSD). We hypothesized that, with a history of sexual abuse, higher levels of PTSD symptoms would be associated with more daily hassles, fewer daily uplifts, and more maladaptive coping strategies, and that there would be more reporting of severe types of sexual victimization, less resourceful socioeconomic conditions and a lower level of emotional stability. Read More

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http://dx.doi.org/10.1177/0886260520935479DOI Listing

The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19.

Am J Physiol Gastrointest Liver Physiol 2020 Jul 8. Epub 2020 Jul 8.

National Clinical Research Center for Child Health, Zhejiang University School of Children's Hospital, China.

In addition to the typical respiratory response, new coronavirus pneumonia (COVID-19) is also associated with very common gastrointestinal symptoms. Cases with gastrointestinal symptoms are more likely to be complicated by liver injury and acute respiratory distress syndrome (ARDS), and diarrhea can also lead to electrolyte disturbances, causing nausea and vomiting, headache, fatigue, etc. If not treated in time, coma and circulatory failure may ensue. Read More

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http://dx.doi.org/10.1152/ajpgi.00148.2020DOI Listing

Engineering a Kerr-Based Deterministic Cubic Phase Gate via Gaussian Operations.

Phys Rev Lett 2020 Jun;124(24):240503

E. L. Ginzton Laboratory, Stanford University, Stanford, California 94305, USA.

We propose a deterministic, measurement-free implementation of a cubic phase gate for continuous-variable quantum information processing. In our scheme, the applications of displacement and squeezing operations allow us to engineer the effective evolution of the quantum state propagating through an optical Kerr nonlinearity. Under appropriate conditions, we show that the input state evolves according to a cubic phase Hamiltonian, and we find that the cubic phase gate error decreases inverse quartically with the amount of quadrature squeezing, even in the presence of linear loss. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.240503DOI Listing

Observation of Protected Photonic Edge States Induced by Real-Space Topological Lattice Defects.

Phys Rev Lett 2020 Jun;124(24):243602

Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Topological defects (TDs) in crystal lattices are elementary lattice imperfections that cannot be removed by local perturbations, due to their real-space topology. In the emerging field of topological photonics, photonic topological edge states arise from the nontrivial topology of the band structure defined in momentum space and are generally protected against defects. Here we show that adding TDs into a valley photonic crystal generates a lattice disclination that acts like a domain wall and hosts photonic topological edge states. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.243602DOI Listing

Self-Excited Motions of Volatile Drops on Swellable Sheets.

Phys Rev Lett 2020 Jun;124(25):258002

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

When a volatile droplet is deposited on a floating swellable sheet, it becomes asymmetric, lobed and mobile. We describe and quantify this phenomena that involves nonequilibrium swelling, evaporation and motion, working together to realize a self-excitable spatially extended oscillator. Solvent penetration causes the film to swell locally and eventually buckle, changing its shape and the drop responds by moving. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.258002DOI Listing

Search for Nova Presolar Grains: γ-Ray Spectroscopy of ^{34}Ar and its Relevance for the Astrophysical ^{33}Cl(p,γ) Reaction.

Phys Rev Lett 2020 Jun;124(25):252702

Physics Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.

The discovery of presolar grains in primitive meteorites has initiated a new era of research in the study of stellar nucleosynthesis. However, the accurate classification of presolar grains as being of specific stellar origins is particularly challenging. Recently, it has been suggested that sulfur isotopic abundances may hold the key to definitively identifying presolar grains with being of nova origins and, in this regard, the astrophysical ^{33}Cl(p,γ)^{34}Ar reaction is expected to play a decisive role. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.252702DOI Listing

Dynamo in Weakly Collisional Nonmagnetized Plasmas Impeded by Landau Damping of Magnetic Fields.

Phys Rev Lett 2020 Jun;124(25):255102

Department of Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.

We perform fully kinetic simulations of flows known to produce dynamo in magnetohydrodynamics (MHD), considering scenarios with low Reynolds number and high magnetic Prandtl number, relevant for galaxy cluster scale fluctuation dynamos. We find that Landau damping on the electrons leads to a rapid decay of magnetic perturbations, impeding the dynamo. This collisionless damping process operates on spatial scales where electrons are nonmagnetized, reducing the range of scales where the magnetic field grows in high magnetic Prandtl number fluctuation dynamos. Read More

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http://dx.doi.org/10.1103/PhysRevLett.124.255102DOI Listing

Mechanisms of pH-dependent uptake of ionizable organic chemicals by fish from oil sands process-affected water (OSPW).

Environ Sci Technol 2020 Jul 8. Epub 2020 Jul 8.

Uptake and effects of ionizable organic chemicals (IOCs) that are weak acids in aqueous solution by fish can differ as a function of pH. While the pH-dependent behavior of select IOCs is well-understood, complex mixtures of IOCs, e.g. Read More

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http://dx.doi.org/10.1021/acs.est.0c02522DOI Listing

Improving Enzyme Optimum Temperature Prediction with Resampling Strategies and Ensemble Learning.

J Chem Inf Model 2020 Jul 8. Epub 2020 Jul 8.

Accurate prediction of the optimal catalytic temperature (T) of enzymes is vital in biotechnology, as enzymes with high T values are desired for enhanced reaction rates. Recently, a machine-learning method (TOME) for predicting T was developed. TOME was trained on a normally-distributed dataset with a median T of 37°C and less than five percent of T values above 85°C, limiting the method's predictive capabilities for thermostable enzymes. Read More

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http://dx.doi.org/10.1021/acs.jcim.0c00489DOI Listing

An Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry and Protein Footprinting.

Anal Chem 2020 Jul 8. Epub 2020 Jul 8.

Bispecific antibodies (BsAbs), with a unique mechanism of recognizing two different epitopes or antigens, have shown potential in various therapeutic areas. Molecular characterization of BsAbs' epitopes not only allows detailed understanding of their mechanism of actions, but also guides the design and selection of drug candidate molecules. In this study, we illustrate the practical utility of an integrated approach, including size exclusion chromatography with multi-angle light scattering and native mass spectrometry (MS), for the biophysical characterization of complex formation of a BsAb with two target antigens, cluster of differentiation 3 (CD3) and B-cell maturation antigen (BCMA). Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01876DOI Listing

Entangled Nanoplasmonic Cavities for Estimating Thickness of Surface-Adsorbed Layers.

ACS Nano 2020 Jul 8. Epub 2020 Jul 8.

Canary Center at Stanford for Cancer Early Detection, Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Department of Radiology, Stanford School of Medicine, Stanford University, Palo Alto, California 94304, United States.

Plasmonic sensors provide real-time and label-free detection of biotargets with unprecedented sensitivity and detection limit. However, they usually lack the ability to estimate the thickness of the target layer formed on top of the sensing surface. Here, we report a sensing modality based on reflection spectroscopy of a nanoplasmonic Fabry-Perot cavity array, which exhibits characteristics of both surface plasmon polaritons and localized plasmon resonances and outperforms its conventional counterparts by providing the thickness of the surface-adsorbed layers. Read More

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http://dx.doi.org/10.1021/acsnano.0c02797DOI Listing

Molecular interaction studies of zinc sulphide nanoparticles with DNA and its consequence: a multi-technique approach.

Luminescence 2020 Jul 8. Epub 2020 Jul 8.

Department of Chemistry, Government Science College, Bengaluru, India.

Molecular interaction studies between NPs and biomolecules are of great importance in the field of nanomedicine, as they affect many physiological processes. Thus, the interaction of zinc sulphide nanoparticles (ZnS NPs) with calf thymus deoxyribonucleic acid (CT DNA) and its significance was analysed using UV-visible, fluorescence, circular dichroism (CD), zeta potential, viscometry, electrochemical and polymerase chain reaction methods. Fluorescence quenching analysis revealed that the fluorescence of ZnS NPs was quenched by CT DNA via static quenching mechanism. Read More

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http://dx.doi.org/10.1002/bio.3912DOI Listing

High tolerance to instrument drifts by differential chemical isotope labeling LC-MS: A case study of the effect of LC leak in long-term sample runs on quantitative metabolome analysis.

J Mass Spectrom 2020 Jun 11:e4589. Epub 2020 Jun 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Metabolomics study of a biological system often involves the analysis of many comparative samples over a period of several days or weeks. This process of long-term sample runs can encounter unexpected instrument drifts such as small leaks in liquid chromatography-mass spectrometry (LC-MS), degradation of column performance, and MS signal intensity change. A robust analytical method should ideally tolerate these instrumental drifts as much as possible. Read More

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http://dx.doi.org/10.1002/jms.4589DOI Listing

Golden retriever pigmentary uveitis: Challenges of diagnosis and treatment.

Vet Ophthalmol 2020 Jul 8. Epub 2020 Jul 8.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Pigmentary uveitis (PU), also known as Golden Retriever Pigmentary Uveitis (GRPU), is a common ocular condition of Golden Retrievers that has severe, vision-threatening ocular complications and can require surgical intervention. In order to ensure consistency in the diagnosis of GRPU between examiners, a specified set of diagnostic criteria must be applied. This is critical to ensure owners, breeders, and veterinary ophthalmologists maintain confidence in the ocular certification process. Read More

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http://dx.doi.org/10.1111/vop.12796DOI Listing

Determination and correction of aberrations in full field OCT using phase gradient autofocus by maximizing the likelihood function.

J Biophotonics 2020 Jul 8:e202000112. Epub 2020 Jul 8.

Institute of Applied Physics RAS, Nizhny Novgorod, Russia.

A method for numerical estimation and correction of aberrations of the eye in fundus imaging with optical coherence tomography (OCT) is presented. Aberrations are determined statistically by using the estimate based on likelihood function maximization. The method can be considered as an extension of the phase gradient autofocusing algorithm in synthetic aperture radar imaging to 2D optical aberration correction. Read More

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http://dx.doi.org/10.1002/jbio.202000112DOI Listing

Head Repositioning during Neurointerventional Procedures to Optimize Biplanar Imaging.

J Neuroimaging 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC.

Background And Purpose: Head positioning is an important aspect for surgical planning in any cranial procedure. However, in neurointerventional cases, this is an afterthought due to advances in biplane imaging. We aim to present that the concept of head positioning may be applied to neurointerventional procedures to obtain optimal working projections to aide in the treatment of neurovascular pathology. Read More

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http://dx.doi.org/10.1111/jon.12750DOI Listing
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