Regul Toxicol Pharmacol 2021 Aug 1:105021. Epub 2021 Aug 1.
Sorbonne Université, INSERM, CNRS, IHU FOReSight, Institut de la Vision, 75012 Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DGOS CIC 1423, IHU FOReSight, 75012, France; Université de Paris, Faculté de Pharmacie de Paris, 75006 Paris, France. Electronic address:
Until now, the Draize test on rabbits has been the only test performed to anticipate ocular toxicity of pharmaceutical compounds, mainly irritation. The OECD is urging the scientific community to develop and validate alternative methods to reduce the need for animal testing. Since the models and tests used cannot reflect the entire biologic response, it is necessary to combine them into integrated approaches to testing and assessment (IATA) to obtain robust data. Read More