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Appl Mech Rev 2019 Jul 23;71(4):0408031-4080313. Epub 2019 Jul 23.

The Key Laboratory of Biomedical InformationEngineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.

Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Read More

Appl Mech Rev 2014 Sep 29;66(5):0508021-5080216. Epub 2014 May 29.

Professor Mathematical Soft Matter Unit, Okinawa Institute of Science and Technology , 1919-1 Tancha, Onna-son, Kunigami-gun , Okinawa, Japan 904-0495 e-mail: 

Transport theorems, such as that named after Reynolds, are an important tool in the field of continuum physics. Recently, Seguin and Fried used Harrison's theory of differential chains to establish a transport theorem valid for evolving domains that may become irregular. Evolving irregular domains occur in many different physical settings, such as phase transitions or fracture. Read More

Appl Mech Rev 2014 May 30;66(3):0308031-3080319. Epub 2014 Apr 30.

Department of Materials Science and Engineering, University of Washington , Seattle, WA 98195;

Tooth fracture is a major concern in the field of restorative dentistry. However, knowledge of the causes for tooth fracture has developed from contributions that are largely based within the field of mechanics. The present manuscript presents a technical review of advances in understanding the fracture of teeth and the fatigue and fracture behavior of their hard tissues (i. Read More

Appl Mech Rev 2014 May 18;66(3):0308011-3080114. Epub 2014 Apr 18.

Bioinspired Engineering and Biomechanics Center, Xi'an Jiaotong University , Xi'an 710049 , China e-mail: 

Thermal pain arising from the teeth is unlike that arising from anywhere else in the body. The source of this peculiarity is a long-standing mystery that has begun to unravel with recent experimental measurements and, somewhat surprisingly, new thermomechanical models. Pain from excessive heating and cooling is typically sensed throughout the body through the action of specific, heat sensitive ion channels that reside on sensory neurons known as nociceptors. Read More

Appl Mech Rev 2014 Jun;66(5)

Mechanical and Aerospace Engineering Department, Institute for Engineering in Medicine, Bioengineering Department, University of California, San Diego, La Jolla, CA.

Migrating cells exert traction forces when moving. Amoeboid cell migration is a common type of cell migration that appears in many physiological and pathological processes and is performed by a wide variety of cell types. Understanding the coupling of the biochemistry and mechanics underlying the process of migration has the potential to guide the development of pharmacological treatment or genetic manipulations to treat a wide range of diseases. Read More