1,057,935 results match your criteria Applied Measurement In Education[Journal]


Impact of hospital geographic remoteness on short-term outcomes after colorectal cancer resection using state-wide administrative data.

ANZ J Surg 2020 May 26. Epub 2020 May 26.

Colorectal Surgical Unit, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Background: This study aimed to use validated coding algorithms, applied to a central repository of administrative data (AD), to report on short-term outcomes following resection for colorectal cancer (CRC) comparing regional to metropolitan Victorian hospitals.

Methods: This is a retrospective cohort study using prospectively gathered AD. The primary outcome was prolonged length of stay (LOS). Read More

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http://dx.doi.org/10.1111/ans.15992DOI Listing

Antifungal activity of propyl disulfide from neem against Lasiodiplodia theobromae and Neofusicoccum parvum causing stem end rot in mango.

J Appl Microbiol 2020 May 26. Epub 2020 May 26.

Department of Packaging and Materials Technology, Kasetsart University, Bangkok, 10900, Thailand.

Aim: To investigate the antifungal effect of the neem extract volatile propyl disulfide against the fungal plant pathogens.

Methods And Results: Postharvest pathogens were isolated and identified as Lasiodiplodia theobromae and Neofusicoccum parvum causing the stem end rot of mango fruit. Antifungal activity of propyl disulfide at different concentrations was determined in comparison with ethanol and distilled water. Read More

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http://dx.doi.org/10.1111/jam.14725DOI Listing

Year effects: Inter-annual variation as a driver of community assembly dynamics.

Ecology 2020 May 26. Epub 2020 May 26.

Department of Plant Sciences, University of California, Davis, CA, 95616, USA.

Environmental conditions that vary from year-to-year can be strong drivers of ecological dynamics, including the composition of newly assembled communities. However, ecologists often chalk such dynamics up to "noise" in ecological experiments. Our lack of attention to such "year effects" hampers our understanding of contingencies in ecological assembly mechanisms and limits the generalizability of research findings. Read More

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http://dx.doi.org/10.1002/ecy.3104DOI Listing

Development and validation of explainable AI-based decision-supporting tool for prostate biopsy.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, South Korea.

Objectives: To develop and validate a risk calculator for prostate cancer (PC) and clinically significant PC (csPC) using explainable artificial intelligence (XAI).

Materials And Methods: We used data of 3791 patients to develop and validate the risk calculator. We initially divided the data into development and validation sets. Read More

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http://dx.doi.org/10.1111/bju.15122DOI Listing

Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke.

Hamostaseologie 2020 Jun 26;40(2):153-164. Epub 2020 May 26.

Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.

Platelets are anucleate cells known for their essential function in hemostasis and formation of thrombi under pathologic conditions. In recent years, strong evidence emerged demonstrating the critical involvement of platelets in inflammatory processes including acute ischemic stroke (AIS), which is one of the leading causes of death and disability worldwide. Recanalization of the occluded brain artery to reconstitute cerebral blood flow is the primary goal in the treatment of stroke patients. Read More

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http://dx.doi.org/10.1055/a-1151-9519DOI Listing

Polymorphism of CD36 Determines Fat Discrimination but Not Intake of High-Fat Food in 20- to 40-Year-Old Adults.

J Nutr 2020 May 26. Epub 2020 May 26.

Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The determinants of the intake of high-fat products are not well understood.

Objective: The aim of this study was to examine the relations between fat perception, intake of high-fat food, and body-weight status, taking into account the polymorphism of the genes that encode the proteins involved in oral fat perception.

Methods: A total of 421 participants aged 20-40 y were enrolled in Poznań, Poland, from 2016 to 2018. Read More

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http://dx.doi.org/10.1093/jn/nxaa136DOI Listing

Targeting Precision with Data Augmented Samples in Deep Learning.

Med Image Comput Comput Assist Interv 2019 Oct 10;11769:284-292. Epub 2019 Oct 10.

Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

In the last five years, deep learning (DL) has become the state-of-the-art tool for solving various tasks in medical image analysis. Among the different methods that have been proposed to improve the performance of Convolutional Neural Networks (CNNs), one typical approach is the augmentation of the training data set through various transformations of the input image. Data augmentation is typically used in cases where a small amount of data is available, such as the majority of medical imaging problems, to present a more substantial amount of data to the network and improve the overall accuracy. Read More

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http://dx.doi.org/10.1007/978-3-030-32226-7_32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243959PMC
October 2019

Indocyanine Green-Coated Polycaprolactone Micelles for Fluorescence Imaging of Tumors.

ACS Appl Bio Mater 2020 Apr 8;3(4):2344-2349. Epub 2020 Mar 8.

Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

Recently, near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG) have received tremendous interest as contrast agents for use in fluorescence-guided, intraoperative cancer resection surgery. However, despite showing great promise, ICG has many shortcomings such as rapid clearance and poor tumor accumulation. To improve the selective accumulation of ICG within tumors, numerous groups have formulated ICG into nanoparticles, but these approaches can suffer from rapid leakage of ICG, use of materials that exhibit poor or incomplete excretion, or complex chemistries that are not easily amenable to scale up for clinical use. Read More

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http://dx.doi.org/10.1021/acsabm.0c00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245056PMC

Associations of Novel Dietary and Lifestyle Inflammation Scores With Incident Colorectal Cancer in the NIH-AARP Diet and Health Study.

JNCI Cancer Spectr 2020 Jun 5;4(3):pkaa009. Epub 2020 Mar 5.

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.

Background: Chronically higher inflammation, likely contributed to by dietary and lifestyle exposures, may increase risk for colorectal cancer (CRC). To address this, we investigated associations of novel dietary (DIS) and lifestyle (LIS) inflammation scores with incident CRC in the prospective National Institutes of Health-American Association of Retired Persons Diet and Health Study (N = 453 465).

Methods: The components of our previously developed and externally validated 19-component DIS and 4-component LIS were weighted based on their strengths of associations with a panel of circulating inflammation biomarker concentrations in a diverse subset (N = 639) of participants in the REasons for Geographic and Racial Differences in Stroke Study cohort. Read More

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http://dx.doi.org/10.1093/jncics/pkaa009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236782PMC

Integrated Digital Microfluidic Platform for Colorimetric Sensing of Nitrite.

ACS Omega 2020 May 4;5(19):11196-11201. Epub 2020 May 4.

Shanghai Key Laboratory of Forensic Medicine (Academy of Forensic Science), Shanghai 200063, P. R. China.

In this paper, a palm-size digital microfluidic (DMF) platform integrated with colorimetric analysis was developed for quantifying the concentration of nitrite. To realize the on-chip repeatable colorimetric analysis, a novel printed circuit board (PCB)-based DMF chip was designed with an embedded aperture on the actuator electrode, forming a vertical light path for online measurement of the droplets. The capabilities of the DMF platform enable automatic manipulation of microliter-level droplets to implement Griess assay without the use of external systems such as syringe, pump, or valve, which provides the benefits including high flexibility, portability, miniature size, and low cost. Read More

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http://dx.doi.org/10.1021/acsomega.0c01274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241042PMC

Arene-Ruthenium(II) Complexes Containing 11-Indeno[1,2-]quinoxalin-11-one Derivatives and Tryptanthrin-6-oxime: Synthesis, Characterization, Cytotoxicity, and Catalytic Transfer Hydrogenation of Aryl Ketones.

ACS Omega 2020 May 7;5(19):11167-11179. Epub 2020 May 7.

Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Avenue, 630090 Novosibirsk, Russia.

A series of novel mono- and binuclear arene-ruthenium(II) complexes [(-cym)Ru(L)Cl] containing 11-indeno[1,2-]quinoxalin-11-one derivatives or tryptanthrin-6-oxime were synthesized and characterized by X-ray crystallography, IR, NMR spectroscopy, cyclic voltammetry, and elemental analysis. Theoretical calculations invoking singlet state geometry optimization, solvation effects, and noncovalent interactions were done using density functional theory (DFT). DFT calculations were also applied to evaluate the electronic properties, and time-dependent DFT was applied to clarify experimental UV-vis results. Read More

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http://dx.doi.org/10.1021/acsomega.0c01204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241045PMC

Mesoporous Polymer-Derived Ceramic Membranes for Water Purification via a Self-Sacrificed Template.

ACS Omega 2020 May 5;5(19):11100-11105. Epub 2020 May 5.

Engineering Laboratory of Advanced Energy Materials, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, No. 1219 Zhongguan West Road, Zhenhai District, Ningbo, Zhejiang 315201, P. R. China.

Membrane separation has been widely used in water purification, and mesoporous ceramic membranes show a high potential in the future because of their high stability and resistance to harsh environments. In the current study, a novel polymer-derived ceramic silicon oxycarbide (SiOC) membrane was developed via a preceramic reactive self-sacrificed method and was further applied in a homemade dead-end system for water purification. A cyclosiloxane hybrid polymer was selected as the precursor and polydimethylsiloxane (PDMS) was used as the sacrificial template. Read More

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http://dx.doi.org/10.1021/acsomega.0c01021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241006PMC

Theoretical and Experimental Study of Compression Effects on Structural Relaxation of Glass-Forming Liquids.

ACS Omega 2020 May 5;5(19):11035-11042. Epub 2020 May 5.

Department of Nanotechnology for Sustainable Energy, School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Hyogo, Japan.

We develop the elastically collective nonlinear Langevin equation theory of bulk relaxation of glass-forming liquids to investigate molecular mobility under compression conditions. The applied pressure restricts more molecular motion and therefore significantly slows down the molecular dynamics when increasing the pressure. We quantitatively determine the temperature and pressure dependence of the structural relaxation time. Read More

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http://dx.doi.org/10.1021/acsomega.0c00860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241026PMC

Preparation of a Polypyrrole/Graphene Oxide Composite Electrode by Electrochemical Codeposition for Capacitor Deionization.

ACS Omega 2020 May 4;5(19):10995-11004. Epub 2020 May 4.

CNPC Tubular Goods Research Institute, Xi'an 710065, Shaanxi, China.

In this paper, a polypyrrole/graphene oxide (PPy/GO) composite electrode, applied to the capacitive deionization process for removing heavy metal ions, was prepared by one-step electrochemical codeposition. The PPy/GO composite electrode has a dense sheet structure, and PPy is spherical and uniformly distributed on the surface of GO sheets. The experimental results show that the PPy/GO composite electrode has a higher capacitance (186. Read More

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http://dx.doi.org/10.1021/acsomega.0c00817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241012PMC

Edge Defect-Free Anisotropic Two-Dimensional Sheets with Nearly Direct Band Gaps from a True One-Dimensional Van der Waals NbSe Material.

ACS Omega 2020 May 6;5(19):10800-10807. Epub 2020 May 6.

Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Dangling-bond-free two-dimensional (2D) materials can be isolated from the bulk structures of one-dimensional (1D) van der Waals materials to produce edge-defect-free 2D materials. Conventional 2D materials have dangling bonds on their edges, which act as scattering centers that deteriorate the transport properties of carriers. Highly anisotropic 2D sheets, made of 1D van der Waals NbSe material, have three planar structures depending on the cutting direction of the bulk NbSe crystal. Read More

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http://dx.doi.org/10.1021/acsomega.0c00388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240825PMC

Development of a Method for Screening and Genotyping of HCV 1a, 1b, 2, 3, 4, and 6 Genotypes.

ACS Omega 2020 May 8;5(19):10794-10799. Epub 2020 May 8.

Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 24252, South Korea.

The World Health Organization and the World Health Assembly recommended eradicating hepatitis as a public threat by 2030. The accurate genotyping of hepatitis C virus (HCV) is crucial to achieving this goal because it is vital for the selection of anti-HCV therapy required for complete cure of HCV infection. We report the development of a method for accurate genotyping of HCV 1a, 1b, 2, 3, 4, and 6 genotypes. Read More

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http://dx.doi.org/10.1021/acsomega.0c00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240817PMC

Effects of Agave Fructans, Inulin, and Starch on Metabolic Syndrome Aspects in Healthy Wistar Rats.

ACS Omega 2020 May 6;5(19):10740-10749. Epub 2020 May 6.

Instituto de Investigacion de Zonas Desérticas, Universidad Autónoma de San Luis Potosí, Altair200 Fracc. del Llano C.P., 78377 San Luis Potosí, S.L.P., México.

Healthy Wistar rats were supplemented during 20 weeks with commercial inulin (I) and fructans (CAT), experimental fructans from (EAT) and (AS) mature stems, rice starch 10% (RS), and standard feed for rodents (C). Feed intake was kept steady, but with I, body weight and abdominal adipose tissue (6.01 g) decreased at the end. Read More

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http://dx.doi.org/10.1021/acsomega.0c00272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240812PMC

Ultrafast Exciton Dynamics in Scalable Monolayer MoS Synthesized by Metal Sulfurization.

ACS Omega 2020 May 4;5(19):10725-10730. Epub 2020 May 4.

Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan.

Excitons in monolayer transition metal dichalcogenides (TMDs) have exceptionally large binding energies and dominate the optical properties of materials. Exploring the relaxation behavior of excitons is crucial for understanding the fundamental physics as well as the performance of TMD-based optoelectronic devices. However, ultrafast carrier dynamics is sensitive to the structural defects and surface conditions of TMDs, depending on the growth or transfer process. Read More

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http://dx.doi.org/10.1021/acsomega.0c00187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240830PMC

Influence of Mineral Composition of Chars Derived by Hydrothermal Carbonization on Sorption Behavior of CO, CH, and O.

ACS Omega 2020 May 8;5(19):10704-10714. Epub 2020 May 8.

Applied Thermodynamics, Chemnitz University of Technology, 09126 Chemnitz, Germany.

The doping of SiO and FeO into hydrochars that were produced by the hydrothermal carbonization of cellulose was studied with respect to its impact on the resulting surface characteristics and sorption behavior of CO, CH, and O. During pyrolysis, the structural order of the Fe-doped char changed, as the fraction of highly ordered domains increased, which was not observed for the undoped and Si-doped chars. The Si doping had no apparent influence on the oxidation temperature of the hydrochar in contrast to the Fe-doped char where the oxidation temperature was reduced because of the catalytic effect of Fe. Read More

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http://dx.doi.org/10.1021/acsomega.9b04370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240835PMC

Contribution of Organofluorine Compounds to Pharmaceuticals.

ACS Omega 2020 May 22;5(19):10633-10640. Epub 2020 Apr 22.

Department of Life Science and Applied Chemistry, Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-5888, Japan.

Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro-pharmaceuticals, have been attracting attention for more than half of a century. Presently, about 20% of the commercial pharmaceuticals are fluoro-pharmaceuticals. In this mini-review, we analyze the prevalence of fluoro-pharmaceuticals in the market and categorize them into several groups based on the chemotype of the fluoro-functional groups, their therapeutic purpose, and the presence of heterocycles and/or chirality to highlight the structural motifs, patterns, and promising trends in fluorine-based drug design. Read More

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http://dx.doi.org/10.1021/acsomega.0c00830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240833PMC

Effects of light intensities and varying watering intervals on growth, tissue nutrient content and antifungal activity of hydroponic cultivated L. under greenhouse conditions.

Heliyon 2020 May 17;6(5):e03906. Epub 2020 May 17.

Department of Horticulture Sciences, Faculty of Applied Sciences, Cape Peninsula University of Technology, Symphony Way, Bellville, 7535, Cape Town, South Africa.

Optimization of the quality and quantity of medicinal materials during cultivation could improve the value of medicinal plants. Light intensity and water availability affect physiological processes and growth of plants. L. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235940PMC

When predictions are used to allocate scarce health care resources: three considerations for models in the era of Covid-19.

Diagn Progn Res 2020 20;4:11. Epub 2020 May 20.

3Feinstein Institutes for Medical Research, Northwell Health, New York City, NY USA.

Background: The need for life-saving interventions such as mechanical ventilation may threaten to outstrip resources during the Covid-19 pandemic. Allocation of these resources to those most likely to benefit can be supported by clinical prediction models. The ethical and practical considerations relevant to predictions supporting decisions about microallocation are distinct from those that inform shared decision-making in ways important for model design. Read More

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http://dx.doi.org/10.1186/s41512-020-00079-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238723PMC

Genome-Wide Analysis, Characterization, and Expression Profile of the Basic Leucine Zipper Transcription Factor Family in Pineapple.

Int J Genomics 2020 11;2020:3165958. Epub 2020 May 11.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Key Laboratory of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Center for Genomics and Biotechnology, College of Life Science, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian Province, China.

This study identified 57 basic leucine zipper (bZIP) genes from the pineapple genome, and the analysis of these bZIP genes was focused on the evolution and divergence after multiple duplication events in relation to the pineapple genome fusion. According to bioinformatics analysis of a phylogenetic tree, the bZIP gene family was divided into 11 subgroups in pineapple, , and rice; gene structure and conserved motif analyses showed that bZIP genes within the same subgroup shared similar intron-exon organizations and motif composition. Further synteny analysis showed 17 segmental duplication events with 27 bZIP genes. Read More

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http://dx.doi.org/10.1155/2020/3165958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238347PMC

Multiple umbilical cord-derived MSCs administrations attenuate rat osteoarthritis progression via preserving articular cartilage superficial layer cells and inhibiting synovitis.

J Orthop Translat 2020 Jul 23;23:21-28. Epub 2020 Apr 23.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China.

Background/objectives: Articular cartilage erosion probably plays a substantial role in osteoarthritis (OA) initiation and development. Studies demonstrated that umbilical cord-derived mesenchymal stem cells (UCMSCs) could delay chondrocytes apoptosis and ameliorate OA progression in patients, but the detailed mechanisms are largely uncharacterised. In this study, we aimed to study the effects of UCMSCs on monosodium iodoacetate (MIA)-induced rat OA model, and explore the cellular mechanism of this effect. Read More

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http://dx.doi.org/10.1016/j.jot.2020.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235619PMC

Double Ureter: Incidence, Types, and Its Applied Significance-A Cadaveric Study.

Cureus 2020 Apr 21;12(4):e7760. Epub 2020 Apr 21.

Anatomy, Chettinad Hospital and Research Institute, Chennai, IND.

Introduction Congenital ureter anomalies such as double ureters are uncommon developmental anomalies of the renal system. An abnormal branching pattern of ureteric bud results in the formation of double ureter. This study examined the incidence of double ureter in cadavers of a South Indian population. Read More

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http://dx.doi.org/10.7759/cureus.7760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243094PMC

Natural Products as Sources of Antimalarial Drugs: Ethnobotanical and Ethnopharmacological Studies.

Scientifica (Cairo) 2020 9;2020:7076139. Epub 2020 May 9.

Natural Products Research Unit, Department of Physical Sciences, College of Pure and Applied Sciences, Landmark University, PMB 1001, Omu Aran, Kwara State, Nigeria.

Materials And Methods: For this study, relevant information was procured from the inhabitants via a structured questionnaire to procure the general knowledge of antimalarial medicinal plants. . A total of 90 interviewees (44 men and 46 women) were involved in this survey. Read More

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http://dx.doi.org/10.1155/2020/7076139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238349PMC

Work-Family Conflict among Iranian Emergency Medical Technicians and Its Relationship with Time Management Skills: A Descriptive Study.

Emerg Med Int 2020 11;2020:7452697. Epub 2020 May 11.

Department of Nursing, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: Work-Family Conflict (WFC) is a form of interrole conflict in which an active participation in occupational activities causes strain and interferes with family roles of workers and vice versa. It is a major source of occupational stress among workers and personnel. Emergency Medical Technicians (EMTs) are an important part of the healthcare system that respond to emergencies. Read More

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http://dx.doi.org/10.1155/2020/7452697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238339PMC

Endoscopic Detorsion Results in Sigmoid Volvulus: Single-Center Experience.

Emerg Med Int 2020 13;2020:1473580. Epub 2020 May 13.

Sakarya University Medical Faculty, General Surgery Department, Adapazarı, Turkey.

Endoscopic detorsion is the first-line recommended treatment modality in sigmoid volvulus patients who have no peritoneal irritation signs on admission. In this paper, we present the results of endoscopic detorsion procedures applied at the time of presentation with the diagnosis of sigmoid volvulus and review the current literature about this topic. Read More

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http://dx.doi.org/10.1155/2020/1473580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243014PMC

Pseudodominant Nanophthalmos in a Roma Family Caused by a Novel Variant.

J Ophthalmol 2020 10;2020:6807809. Epub 2020 May 10.

Research Unit for Rare Diseases, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 128 08 Prague, Czech Republic.

Background: The aim of the study was to identify the molecular genetic cause of two different Mendelian traits with ocular involvement present in the members of a single consanguineous Czech Roma family.

Methods: We have performed ocular examination and review of medical records in two individuals diagnosed with nanophthalmos (proband and her father) and one individual followed for bilateral congenital cataract and microcornea (uncle of the proband). DNA of subjects with nanophthalmos was analysed by exome sequencing. Read More

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http://dx.doi.org/10.1155/2020/6807809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212339PMC

Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk: A case-control study.

Mol Clin Oncol 2020 Jul 5;13(1):54-62. Epub 2020 May 5.

Department of Cancer Management and Research, Medical Research Institute, University of Alexandria, Alexandria 21561, Egypt.

Two single nucleotide polymorphisms (SNPs) of matrix metalloproteinase (MMPs) 3 and 9 are functionally implicated in the progression of various types of cancer, including breast cancer (BC). However, the roles of these SNPs remain controversial. In addition, they also vary between one population and another. Read More

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http://dx.doi.org/10.3892/mco.2020.2041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241239PMC

Possible Effects of Perchlorate Contamination of Drinking Water on Thyroid Health.

J Thyroid Res 2020 13;2020:5208657. Epub 2020 May 13.

Department of Community Medicine, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala 680005, India.

Background: Perchlorate is an anion that occurs as a contaminant in groundwater. It originates from the improper disposal of ammonium perchlorate, a component of rocket fuel. The objective of this study was to explore whether the exposure to perchlorate in drinking water had an impact on the thyroid function of the population residing near an ammonium perchlorate plant in Kerala. Read More

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http://dx.doi.org/10.1155/2020/5208657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243002PMC

Evaluation of biofilm accumulation on and deactivation force of orthodontic Ni-Ti archwires before and after exposure to an oral medium: A prospective clinical study.

J Dent Res Dent Clin Dent Prospects 2020 ;14(1):41-47

Department of Dentistry, State University of Maringá, Maringá-Pr, Brazil.

This in vitro study aimed to evaluate biofilm accumulation on and deactivation force of orthodontic nickeltitanium (NiTi) archwires before and after exposure to an oral medium. Four commercial brands of orthodontic NiTi 0.016" archwires were examined before and after exposure to the oral medium for 4 weeks. Read More

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http://dx.doi.org/10.34172/joddd.2020.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235699PMC
January 2020

REGRESSION OF THE NAVIER-STOKES EQUATION SOLUTIONS FOR PULMONARY AIRWAY FLOW USING NEURAL NETWORKS.

Proc IEEE Int Symp Biomed Imaging 2019 Apr 11;2019:1229-1233. Epub 2019 Jul 11.

Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.

Computerized fluid dynamics models of particle deposition in the human airways are used to characterize deposition patterns that enable the study of lung diseases like asthma and chronic obstructive pulmonary disease (COPD). Despite this fact, the influence of patient-specific geometry on the deposition efficiency and patterns is not well documented nor modeled. In part, this is due to the complexity of simulating the full Computational Fluid Dynamics (CFD) solution in patient-specific airway geometries, a factor that becomes a major hurdle for patient-specific studies given the complexity of the geometry of human lungs and their related airflow. Read More

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http://dx.doi.org/10.1109/isbi.2019.8759186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243963PMC

LOCALIZING IMAGE-BASED BIOMARKER REGRESSION WITHOUT TRAINING MASKS: A NEW APPROACH TO BIOMARKER DISCOVERY.

Proc IEEE Int Symp Biomed Imaging 2019 Apr 11;2019:679-682. Epub 2019 Jul 11.

Applied Chest Imaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School. USA.

Biomarker inference from biomedical images is one of the main tasks of medical image analysis. Standard techniques follow a segmentation-and-measure strategy, where the structure is first segmented and then the measurement is performed. Recent work has shown that such strategy could be replaced by a direct regression of the biomarker value in using regression networks. Read More

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http://dx.doi.org/10.1109/isbi.2019.8759474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243964PMC

Adhesion of Hydroxyapatite Nanoparticles to Dental Materials under Oral Conditions.

Scanning 2020 5;2020:6065739. Epub 2020 May 5.

Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University Hospital, D-66421 Homburg, Saarland, Germany.

Hydroxyapatite nanoparticles (nano-HAP) are receiving considerable attention for dental applications, and their adhesion to enamel is well established. However, there are no reports concerning the effects of HAP on other dental materials, and most of the studies in this field are based on designs, neglecting the salivary pellicle-apatite interactions. Thus, this pilot study aims to evaluate the effects of three hydroxyapatite-based solutions and their interactions with different dental material surfaces under oral conditions. Read More

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http://dx.doi.org/10.1155/2020/6065739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222588PMC

The Application of Radiofrequency Waves in Supportive Treatment of Temporomandibular Disorders.

Pain Res Manag 2020 6;2020:6195601. Epub 2020 May 6.

Prosthodontics Department, Consulting Room of Temporomandibular Disorders, Jagiellonian University Medical Collage, 4 Montelupich Str., 31-155 Krakow, Poland.

In recent years, the number of patients applying for prosthetic treatment due to temporomandibular joint disorders (TMD) has been increasing. The main methods for treating disorders are the use of occlusal splints and physiotherapeutic rehabilitation as supportive treatment. Radio waves are electromagnetic waves with radiation frequency between 3 Hz and 3 THz, used for physiotherapeutic treatment of skeletal muscle relaxation in the range of 3 to 6 MHz. Read More

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http://dx.doi.org/10.1155/2020/6195601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225847PMC

Impacts of Coil Treatment on Anxiety and Depression in Emphysema.

Can Respir J 2020 11;2020:4270826. Epub 2020 May 11.

Department of Pulmonology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Chronic obstructive pulmonary disease (COPD) is a widespread, preventable, and treatable disease. Emphysema is one of the primary components of COPD and manifests itself via decrease in elastic recoil, hyperinflation, and increase in air trapping. Various lung-volume-reduction treatments have come up in recent years for late-stage emphysema patients. Read More

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http://dx.doi.org/10.1155/2020/4270826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240628PMC

The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA.

Dis Markers 2020 13;2020:4312629. Epub 2020 May 13.

Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

(protein tyrosine phosphatase nonreceptor type 6), a tyrosine phosphatase, is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Previous studies have demonstrated that expression is relatively elevated in several malignancies. However, the role of in bladder cancer (BC) remains unclear. Read More

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http://dx.doi.org/10.1155/2020/4312629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243021PMC

Is Extra Virgin Olive Oil an Ally for Women's and Men's Cardiovascular Health?

Cardiovasc Ther 2020 24;2020:6719301. Epub 2020 Apr 24.

Laboratorio PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis), DiSIA Università Degli Studi di Firenze, 50019 Florence, Italy.

Noncommunicable diseases are long-lasting and slowly progressive and are the leading causes of death and disability. They include cardiovascular diseases (CVD) and diabetes mellitus (DM) that are rising worldwide, with CVD being the leading cause of death in developed countries. Thus, there is a need to find new preventive and therapeutic approaches. Read More

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http://dx.doi.org/10.1155/2020/6719301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212338PMC

Prediction of Drug Side Effects with a Refined Negative Sample Selection Strategy.

Comput Math Methods Med 2020 9;2020:1573543. Epub 2020 May 9.

College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China.

Drugs are an important way to treat various diseases. However, they inevitably produce side effects, bringing great risks to human bodies and pharmaceutical companies. How to predict the side effects of drugs has become one of the essential problems in drug research. Read More

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http://dx.doi.org/10.1155/2020/1573543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232712PMC

Effects of Massage Therapy on the Development of Babies Born with Down Syndrome.

Evid Based Complement Alternat Med 2020 6;2020:4912625. Epub 2020 May 6.

Department of Physiotherapy, University of Seville, 41009 Seville, Spain.

Objective: To determine the short-term effects of infant massage on the development of Down syndrome babies.

Materials And Methods: The study compared two groups (intervention and control), each with 16 babies with Down syndrome between 4 and 8 months old. The variables developmental age and developmental quotient were measured at two distinct time points, at pretest and after 5 weeks, using the Brunet-Lézine Early Childhood Psychomotor Development revised scale. Read More

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http://dx.doi.org/10.1155/2020/4912625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229556PMC

UNaProd: A Universal Natural Product Database for of Iranian Traditional Medicine.

Evid Based Complement Alternat Med 2020 13;2020:3690781. Epub 2020 May 13.

Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Iranian traditional medicine (ITM) is a holistic medical system that uses a wide range of medicinal substances to treat disease. Reorganization and standardization of the data on ITM concepts is a necessity for optimal use of this rich source. In an initial step towards this goal, we created a database of ITM . Read More

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http://dx.doi.org/10.1155/2020/3690781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243028PMC

Effectiveness of a Global Multidisciplinary Supportive and Educational Intervention in Thermal Resort on Anthropometric and Biological Parameters, and the Disease-Free Survival after Breast Cancer Treatment Completion (PACThe).

J Oncol 2020 5;2020:4181850. Epub 2020 May 5.

Jean Perrin Comprehensive Cancer Centre, Department of Oncogenetics, 58 Rue Montalembert, 63011 Clermont-Ferrand, France.

A growing knowledge highlights the strong benefit of regular physical activity in the management of breast cancer patients, but few studies have considered biological parameters in their outcomes. In the prospective randomised trial after breast cancer treatment completion "PACThe," we determined the effects of physical activity and nutritional intervention on the biological and anthropometric status of patients after one year of follow-up, and clarified the link between biomarkers at allocation and disease-free survival. 113 patients from the population of the "PACThe" study ( = 251) were analysed for biological parameters. Read More

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http://dx.doi.org/10.1155/2020/4181850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222596PMC

Macrophylloflavone: A New Biflavonoid from Mart. (Clusiaceae) for Antibacterial, Antioxidant, and Anti-Type 2 Diabetes Mellitus Activities.

ScientificWorldJournal 2020 12;2020:2983129. Epub 2020 May 12.

Department of Chemistry Education, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.

Investigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. Read More

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http://dx.doi.org/10.1155/2020/2983129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240784PMC

Inhibitory Effect of Roselle Aqueous Extracts-HPMC 6000 Gel on the Growth of ATCC 25923.

Turk J Pharm Sci 2020 Apr 24;17(2):190-196. Epub 2020 Apr 24.

Airlangga University, Faculty of Pharmacy, Department of Pharmaceutics, Surabaya, Indonesia.

Objectives: Roselle ( L.) is a medicinal plant commonly used as a beverage and herbal medicine. Complex compounds in the aqueous extracts have provided good antibacterial activity by which the growth of gram-negative and -positive bacteria is inhibited. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2019.88709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227917PMC

Cleaning Method Validation for Estimation of Dipyridamole Residue on the Surface of Drug Product Manufacturing Equipment Using Swab Sampling and by High Performance Liquid Chromatographic Technique.

Turk J Pharm Sci 2020 Apr 24;17(2):182-189. Epub 2020 Apr 24.

Bluefish Pharmaceuticals Private Limited, Research and Development, Karnataka, India.

Objectives: Cleaning validation is the procedure used to ensure that the cleaning process has eliminated the residues of drug substance from on the equipment surface after manufacture. A simple, sensitive, robust, and accurate high performance liquid chromatographic method was developed for the quantitative estimation of dipyridamole in swab samples obtained from the equipment surface after the manufacture of dipyridamole modified release capsules.

Materials And Methods: The method was developed by using a Hypersil BDS C18 (150×4. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2019.70446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227908PMC

Theoretical Study on Ionization of Boric Acid in Aqueous Solution by and DFT Methods at T=298.15 K.

Turk J Pharm Sci 2020 Apr 24;17(2):177-181. Epub 2020 Apr 24.

Department of Chemistry, Faculty of Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.

Objectives: The aim of this research work was to theoretically calculate the pK value of boric acid in aqueous solution by theoretical methods at T=298.15 K.

Materials And Methods: Boric acid has antifungal and antiviral properties. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.26818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227919PMC

Comparison of Lipid and Lipoprotein Values of Wrestlers and Soccer Players.

Turk J Pharm Sci 2020 Apr 24;17(2):172-176. Epub 2020 Apr 24.

2Lokman Hekim University, Faculty of Sports Science, Ankara, Turkey.

Objectives: The aim of this study was to compare the lipid and lipoprotein values of wrestlers and soccer players.

Materials And Methods: A total of 35 subjects, 17 male wrestlers who are sporting for 11.5 years and 18 male soccer player students who are sporting for 11. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.66934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227909PMC

Investigation of the Presence of Sildenafil in Herbal Dietary Supplements by Validated HPLC Method.

Authors:
Emrah Dural

Turk J Pharm Sci 2020 Feb 19;17(1):56-62. Epub 2020 Feb 19.

Sivas Cumhuriyet University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Sivas, Turkey.

Objectives: As the first FDA-approved phosphodiesterase type 5 inhibitor, sildenafil (SDF) is widely used in the treatment of erectile dysfunction due to its strong pharmacodynamic activity. Since many food supplements are now involved in illegal adulteration, the presence of SDF in food supplements is very important because of their toxicological risks. In this study a simple fast, reliable high-performance liquid chromatography method with ultraviolet (UV) detector has been developed and validated for SDF analysis in herbal dietary supplements (HDSs). Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.91249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227870PMC
February 2020
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