956,783 results match your criteria Applied Measurement In Education[Journal]


Intracranial hypertension in a patient with Class V lupus nephritis.

Nephrology (Carlton) 2019 May;24(5):585

Department of Nephrology, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13432DOI Listing

Different response of bacteria, archaea and fungi to process parameters in nine full-scale anaerobic digesters.

Microb Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Microbiology and Biotechnology, Ulm University, Ulm, Germany.

Biogas production is a biotechnological process realized by complex bacterial, archaeal and likely fungal communities. Their composition was assessed in nine full-scale biogas plants with distinctly differing feedstock input and process parameters. This study investigated the actually active microbial community members by using a comprehensive sequencing approach based on ribosomal 16S and 28S rRNA fragments. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-7915.13
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http://dx.doi.org/10.1111/1751-7915.13409DOI Listing
April 2019
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Gaming National Emergency Access Target performance using Emergency Treatment Performance definitions and emergency department short stay units.

Emerg Med Australas 2019 Apr 17. Epub 2019 Apr 17.

Sax Institute, Sydney, New South Wales, Australia.

Objective: To evaluate potential gaming of the 4 h ED length of stay metric known as the National Emergency Access Target (NEAT) in Australia and Emergency Treatment Performance (ETP) in New South Wales (NSW).

Methods: Descriptive statistical analysis was used to recalculate and compare the scores for NEAT and the NSW ETP using variations in the definitions of their measurement on 32 184 presentations during 2016. A computer simulation using a discrete event model illustrated the effect of the use of ED short stay beds on the ETP scores. Read More

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http://dx.doi.org/10.1111/1742-6723.13295DOI Listing

Quantitative magnetic force microscopy using calibration on superconducting flux quanta.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

Physics, Universita degli Studi di Salerno, Fisciano, Campania, ITALY.

We present a new procedure that takes advantage of the magnetic flux quantization of superconducting vortices to calibrate the magnetic properties of tips for magnetic force microscopy (MFM). Indeed, a superconducting vortex, whose quantized flux is dependent upon Plank constant, speed of light and electron charge, behaves as a very well defined magnetic reference object. The proposed calibration procedure has been tested on new and worn tips and shows that the monopole point-like approximation of the probe is a reliable model. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1a4dDOI Listing

Efficient detrending of uniform images for accurate determination of the noise power spectrum at low frequencies.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, SPAIN.

The noise power spectrum (NPS) of a digital x-ray imaging device is usually estimated from the average of periodograms of ROIs in images obtained with uniform radiation fields. In order to mitigate low frequency trends, present in the images and not arising from stochastic processes, detrending methods are applied to the images before being Fourier transformed. The most common of these methods subtracts a second-order polynomial fit from the image. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1a68DOI Listing

Radiocarbon dating of ivory: Potentialities and limitations in forensics.

Forensic Sci Int 2019 Mar 30;299:114-118. Epub 2019 Mar 30.

CEDAD (CEntre for applied physics, DAting and Diagnostic) Department of Mathematics and Physics "Ennio de Giorgi", University of Salento, Italy.

The determination of the age of elephant ivory is a crucial aspect in the fight against illegal ivory trade which is still a relevant problem having triggered the decline of elephant populations due to poaching in different areas of the globe. Indeed, the absolute dating of the ivory allows, in forensics practice, to establish whether a determined sample or object was obtained and imported illegally, violating the international trade ban. In this frame the use radiocarbon dating has surely a great potential and is widely used. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.03.042DOI Listing

Halogenated flame retardants in mangrove sediments from the Pearl River Estuary, South China: Comparison with historical data and correlation with microbial community.

Chemosphere 2019 Apr 11;227:315-322. Epub 2019 Apr 11.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

Polybrominated diphenyl ethers (PBDEs), decabromodiphenyl ethane (DBDPE), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), tetrabromobisphenol A (TBBPA), hexabromocyclododecane (HBCDD) and dechlorane plus (DP) were measured in sediments collected from three mangrove wetlands of the Pearl River Estuary (PRE) in South China. This study aims to investigate the distribution of these halogenated flame retardants (HFRs) and the correlations between HFRs and microbial community structure in mangrove sediments. Concentrations of PBDEs, DBDPE, BTBPE, TBBPA, HBCDD and DP in mangrove sediments ranged from 6. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.075DOI Listing

Quantitation of vitamin K1 in serum using online SPE-LC-MS/MS and the challenges of working with vitamin K.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 7;1117:41-48. Epub 2019 Apr 7.

Department of Clinical Biochemistry and Immunology, Lillebaelt Hospital, Vejle, Denmark.

Vitamin K1 (phylloquinone) is one of the vitamin Ks. Several studies have previously investigated the role of vitamin K1 status in respect to disease, but without consistent results. Since vitamin K deficiency has been associated with different disease states it is important to develop a biochemical analysis with sufficient sensitivity and a low limit of quantitation (LOQ). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183176
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http://dx.doi.org/10.1016/j.jchromb.2019.04.010DOI Listing
April 2019
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Accurately quantifying the reductive capacity of microbial extracellular polymeric substance by mediated electrochemical oxidation method.

Sci Total Environ 2019 Apr 10;673:541-545. Epub 2019 Apr 10.

CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science and Technology of China, Hefei, 230026, China. Electronic address:

The reductive capacity of microbial extracellular polymeric substances (EPS) plays important roles in environmental processes involved in heavy metal detoxification and organic contaminant degradation. However, the crucial parameter to evaluate the reductive capacity of EPS, electron donating capacity (EDC) lacks a quantitative approach. In this study, a novel mediated electrochemical oxidation (MEO) method was developed to investigate the EDCs of microbial EPS extracted from Shewanella oneidensis MR-1 (S. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.130DOI Listing

Perylenequinone-based "turn on" fluorescent probe for hydrogen sulfide with high sensitivity in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Mar 29;218:206-212. Epub 2019 Mar 29.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China. Electronic address:

Hydrogen sulfide (HS) is a kind of gaseous signal molecule in many physiological processes. In order to detect HS, a novel "turn on" fluorescent probe 6,12-dihydroxyperylene-1,7-dione (DPD) was designed and synthesized. The probe DPD is fluorescence silence, while the addition of HS induces an obvious green fluorescence with an obvious color change from dark blue to yellow-green. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193036
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http://dx.doi.org/10.1016/j.saa.2019.03.112DOI Listing
March 2019
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Recyclable fluorescent chemodosimeters based on 8-hydroxyquinoline derivatives for highly sensitive and selective detection of mercury(II) in aqueous media and test strips.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 4;218:196-205. Epub 2019 Apr 4.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:

Four novel highly selective 8-hydroxyquinoline-based fluorescent chemodosimeters (1-4) were synthesized for the rapid analysis of Hg in aqueous solution and on paper strips, which probably attributed to the excited state intramolecular proton transfer (ESIPT) process. Chemodosimeter 1 was evaluated as a Hg-ratiometric fluorescent sensor while others (2, 3 and 4) displayed fluorescence turn-on response for Hg among the various survey metal ions. We demonstrated that chemodosimeters (1-4) could recognized Hg ions based on a 1:1 stoichiometric binding event with fast detection time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193037
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http://dx.doi.org/10.1016/j.saa.2019.04.004DOI Listing
April 2019
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Further terpenoids from Euphorbia tirucalli.

Fitoterapia 2019 Apr 14. Epub 2019 Apr 14.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France. Electronic address:

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.001DOI Listing

Seed-based connectivity analysis of resting-state fMRI in patients with brain tumors: a practical approach.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

International Neuroscience Institute, Rudolf-Pichlmayr-Straße 4, D - 30625 Hannover, Germany; Leibniz Institute, Germany.

Objective: In this study, we are presenting our experience using resting state functional magnetic resonsce imaging (rs-fMRI) in preoperative planning. We performed goup analysis to demonestrate the effects of brain tumor on resting state networks (RSNs) METHODS: Thirty patients with supratentorial gliomas were included in the study. Preoperative rs-fMRI and structural MRI were performed in all cases. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.073DOI Listing

Meta-analysis of the prognosis of Different treatments of symptomatic moyamoya disease.

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China; Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, 30052China. Electronic address:

Objective: The purpose of this study was to evaluate the efficacy of surgical revascularization versus conservative treatment and different surgical modalities, in order to provide evidence for the patient with MMD to choose the appropriate treatment.

Methods: We comprehensively searched PubMed, Embase, Web of Science and the Cochrane Library for the articles published regarding MMD treatment. If the I value, which evaluated the heterogeneity, was less than 50%, a fixed effect model was used; if not, a random effect model was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.062DOI Listing

Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits.

Cell Rep 2019 Apr;27(3):872-885.e7

Department of Biology, University of Maryland, College Park, MD 20742, USA; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, USA. Electronic address:

Natural sounds have rich spectrotemporal dynamics. Spectral information is spatially represented in the auditory cortex (ACX) via large-scale maps. However, the representation of temporal information, e. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.069DOI Listing

IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.

Cell Rep 2019 Apr;27(3):835-846.e5

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address:

Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193042
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http://dx.doi.org/10.1016/j.celrep.2019.03.082DOI Listing
April 2019
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The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression.

Cell Rep 2019 Apr;27(3):776-792.e7

Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and host proteins required for viral replication are typically spared in this process, but the mechanisms of target selectivity during host shutoff remain poorly understood. Using transcriptome-wide and targeted reporter experiments, we demonstrate that the influenza A virus endoribonuclease PA-X usurps RNA splicing to selectively target host RNAs for destruction. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.063DOI Listing

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism.

Cell Rep 2019 Apr;27(3):750-761.e7

Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, SP 13083-862, Brazil. Electronic address:

Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-induced colitis. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.054DOI Listing

Exploring the fatigue affecting electroencephalography based functional brain networks during real driving in young males.

Neuropsychologia 2019 Apr 14. Epub 2019 Apr 14.

Department of Mechanical Engineering and Automation, Northeastern University, 110819 Shenyang, Liaoning, China.

In recent years, a large proportion of traffic accidents are caused by driver fatigue. The brain has been conceived as a complex network, whose function can be assessed with EEG. Hence, in this research, fourteen subjects participated in the real driving experiments, and a comprehensive EEG-based expert system was designed for detecting driver fatigue. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.04.004DOI Listing

Strength training and running elicit different neuroprotective outcomes in a β-amyloid peptide-mediated Alzheimer's disease model.

Physiol Behav 2019 Apr 14. Epub 2019 Apr 14.

Applied Neuromechanics Group, Federal University of Pampa, Uruguaiana, 97501-970, Brazil. Electronic address:

Aerobic exercise induces neuroprotection, but few studies investigated whether strength training has similar potential. Here we examine whether effects of strength training differ from those of running training concerning cognitive symptomatology, oxidative stress and cholinergic status in a model of AD-like cognitive impairment induced by intrahippocampal infusion of a mix of β-amyloid peptides (Aβ) in rats. Male Wistar rats were submitted to 8 weeks of running exercise (RunEx; 40 min sessions at 70% of indirect VO max, 3 times/week) or strength exercise (StrEx; 3 sessions/week, 12 repetitions in 8 sets, 2 sets with repetitions at 50%, 2 at 75%, 2 at 90% and 2 at 100% of the maximum load), followed by Aβ infusion in the dorsal hippocampus. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.04.012DOI Listing

Can Predicted Protein 3D-Structures Provide Reliable Insights into whether Missense Variants Are Disease-Associated?

J Mol Biol 2019 Apr 14. Epub 2019 Apr 14.

Structural Bioinformatics Group, Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London SW7 2AZ, UK. Electronic address:

Knowledge of protein structure can be used to predict the phenotypic consequence of a missense variant. Since structural coverage of the human proteome can be roughly tripled to over 50% of the residues if homology-predicted structures are included in addition to experimentally-determined coordinates, it is important to assess the reliability of using predicted models when analysing missense variants. Accordingly, we assess whether a missense variant is structurally damaging by using experimental and predicted structures. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.04.009DOI Listing

ALTERED BRAIN ACTIVITY IN PATIENTS WITH DIABETIC RETINOPATHY USING REGIONAL HOMOGENEITY: A RESTING-STATE fMRI STUDY.

Endocr Pract 2019 Apr;25(4):320-327

Previous neuroimaging studies have shown that diabetic retinopathy (DR) is accompanied by abnormal spontaneous brain activity. The purpose of the current study was to investigate changes in brain neural homogeneity in patients with DR using regional homogeneity (ReHo). A total of 56 subjects were recruited, including 28 patients with DR (16 female and 12 male patients) and 28 healthy controls (HCs) (16 female and 12 male patients) approximately matched for age and sex. Read More

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http://dx.doi.org/10.4158/EP-2018-0517DOI Listing

Control of Wheat Fusarium Head Blight by Heat-Stable Antifungal Factor (HSAF) from .

Plant Dis 2019 Apr 17:PDIS09181517RE. Epub 2019 Apr 17.

1 Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Jiangsu Key Laboratory for Food Quality and Safety, State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing 210014, P.R. China.

Heat-stable antifungal factor (HSAF), which belongs to the polycyclic tetramate macrolactam family, was isolated from fermentations and exhibited inhibitory activities against a wide range of fungal pathogens. In this study, the antifungal activity of HSAF against in vitro and in vivo was investigated. A total of 50% of mycelial growth of was suppressed with 4. Read More

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http://dx.doi.org/10.1094/PDIS-09-18-1517-REDOI Listing

Estimation of Shape, Volume, and Dipole Moment of Individual Proteins Freely Transiting a Synthetic Nanopore.

ACS Nano 2019 Apr 17. Epub 2019 Apr 17.

This paper demonstrates that high-bandwidth current recordings in combination with low-noise silicon nitride nanopores make it possible to determine the molecular volume, approximate shape, and dipole moment of single native proteins in solution without the need for labeling or other chemical modifications of these proteins. The analysis is based on current modulations caused by the translation and rotation of single proteins through a uniform electric field inside of a nanopore. We applied this technique to nine proteins and show that these measured protein parameters agree well with reference values, but only if the nanopore walls were coated with a non-stick fluid lipid bilayer. Read More

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http://dx.doi.org/10.1021/acsnano.8b09555DOI Listing

Potential Technologies Review - A hybrid information retrieval framework to accelerate demand-pull innovation in biomedical engineering.

Res Synth Methods 2019 Apr 17. Epub 2019 Apr 17.

Science Management, Institute of Applied Medical Engineering, RWTH Aachen University, Aachen, Germany.

Launching biomedical innovations based on clinical demands instead of translating basic research findings to practice reduces the risk that the results will not fit the clinical routine. To realize this type of innovation, a meta-analysis of the body of research is necessary to reveal demand-matching concepts. However, both the data deluge and the narrow time constraints for innovation make it impossible to perform such reviews manually. Read More

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http://dx.doi.org/10.1002/jrsm.1350DOI Listing

The zinc finger protein GATA4 induces MET and cellular senescence through the NF-κB pathway in hepatocellular carcinoma.

J Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Laboratory Animal Center, Chongqing Medical University, Chongqing.

Background And Aim: The high mortality and poor prognosis of hepatocellular carcinoma (HCC) have raised the public attention. Gene therapy is considered as a promising treatment option for cancer; thus, finding a new therapeutic target for hepatocellular carcinoma is urgently needed. GATA4 is a tumor suppressor gene in multiple cancers, but its role in HCC is unclear. Read More

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http://dx.doi.org/10.1111/jgh.14684DOI Listing

Where's the fruit? Multidimensional Inequalities in Food Retail Environments around Public Elementary Schools.

Child Care Health Dev 2019 Apr 17. Epub 2019 Apr 17.

Department of Sociology and Anthropology, Marshall University, Huntington, WV, USA.

Background: The increasing number of convenience and small food stores may be contributing to the rising childhood obesity rate in the United States, however, the literature assessing food environments surrounding elementary schools in this country is relatively limited. This study determines: (1) whether the food environments around public elementary schools is of significantly lower quality than those of other areas in the U.S. Read More

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http://dx.doi.org/10.1111/cch.12671DOI Listing
April 2019
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Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

Aarhus University, Centre for DNA Nanotechnology at the Dept. of Chemsitry and iNANO, Gustav Wieds Vej 14, 8000, Aarhus, DENMARK.

The development of methods for conjugation of DNA to proteins is of high relevance for integration of protein function and DNA structures. Here, we demonstrate that protein binding peptides can direct a DNA-templated reaction, furnishing DNA-protein conjugates selectively with one DNA label. Quantitative conversion of oligonucleotides is achieved at low stoichiometries and the reaction can be performed in complex biological matrixes such as cell lysates. Read More

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http://dx.doi.org/10.1002/anie.201903134DOI Listing

Scalable biosynthesis of the seaweed neurochemical kainic acid.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

University of California at San Diego, Scripps Institution of Oceanography, 9500 Gilman Dr., 92093-0204, La Jolla, UNITED STATES.

Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role of ionotropic glutamate receptors, including the kainate receptor, in the central nervous system. Worldwide shortages of this seaweed natural product in 2000 prompted numerous chemical syntheses that now number in excess of 70, including scalable preparations with as few as six-steps. Herein we report the discovery and characterization of the concise two-enzyme biosynthetic pathway to kainic acid from L-glutamic acid and dimethylallyl pyrophosphate in red macroalgae and show that the biosynthetic genes are co-clustered in genomes of Digenea simplex and the edible Palmaria palmata. Read More

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http://dx.doi.org/10.1002/anie.201902910DOI Listing

Performance of Matching Methods to Unmatched Ordinary Least Squares Regression Under Constant Effects.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Center for Population Health Sciences, Department of Medicine, Stanford University, Palo Alto, California.

Matching methods are assumed to reduce the likelihood of a biased inference compared to ordinary least squares regression. Using simulations, we compare inferences from propensity score matching, coarsened exact matching, and un-matched covariate-adjusted ordinary least squares regression (OLS) to identify which methods, in which scenarios, produced unbiased inferences at the expected type I error rate of 5%. We simulated multiple datasets and systematically varied common support, discontinuities in the exposure and / or outcome, exposure prevalence, and analytic model misspecification. Read More

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http://dx.doi.org/10.1093/aje/kwz093DOI Listing

The long-term effects of an implantable drop foot stimulator on gait in hemiparetic patients.

PLoS One 2019 17;14(4):e0214991. Epub 2019 Apr 17.

Christian Doppler Laboratory for Restoration of Extremity Function, Medical University of Vienna, Vienna, Austria.

Drop foot is a frequent abnormality in gait after central nervous system lesions. Different treatment strategies are available to functionally restore dorsal extension during swing phase in gait. Orthoses as well as surface and implantable devices for electrical stimulation of the peroneal nerve may be used in patients who do not regain good dorsal extension. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214991PLOS
April 2019
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Causes of mortality in cases with extra nodal natural killer/T-cell lymphoma, nasal type: A cohort study.

PLoS One 2019 17;14(4):e0214860. Epub 2019 Apr 17.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Objective: Extra nodal natural killer/T-cell lymphoma (ENKTL), nasal type is a rare and highly aggressive type of non-Hodgkin's lymphoma (NHL) commonly presented in the nasal cavity or lymphatic system. However, the common causes of mortality in ENKTL remain unclear. We conducted a retrospective population-based cohort study to elucidate the different causes of mortality in ENKTL and illustrate the main causal and associated risk factors leading to death. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214860PLOS

Decision-making in livestock biosecurity practices amidst environmental and social uncertainty: Evidence from an experimental game.

PLoS One 2019 17;14(4):e0214500. Epub 2019 Apr 17.

Department of Animal and Veterinary Sciences, University of Vermont, Burlington, Vermont, United States of America.

Livestock industries are vulnerable to disease threats, which can cost billions of dollars and have substantial negative social ramifications. Losses are mitigated through increased use of disease-related biosecurity practices, making increased biosecurity an industry goal. Currently, there is no industry-wide standard for sharing information about disease incidence or on-site biosecurity strategies, resulting in uncertainty regarding disease prevalence and biosecurity strategies employed by industry stakeholders. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214500PLOS

Quantification of in vivo transverse relaxation of glutamate in the frontal cortex of human brain by radio frequency pulse-driven longitudinal steady state.

PLoS One 2019 17;14(4):e0215210. Epub 2019 Apr 17.

Section on Magnetic Spectroscopy, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America.

Purpose: The principal excitatory neurotransmitter glutamate plays an important role in many central nervous system disorders. Because glutamate resides predominantly in glutamatergic neurons, its relaxation properties reflect the intracellular environment of glutamatergic neurons. This study developed an improved echo time-independent technique for measuring transverse relaxation time and demonstrated that this radio frequency (RF)-driven longitudinal steady state technique can reliably measure glutamate transverse relaxation in the frontal cortex, where structural and functional abnormalities have been associated with psychiatric symptoms. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215210PLOS

A one-commodity pickup-and-delivery traveling salesman problem solved by a two-stage method: A sensor relocation application.

PLoS One 2019 17;14(4):e0215107. Epub 2019 Apr 17.

School of Civil Engineering, Central South University, Changsha, Hunan, China.

In the carrier-based coverage repair problem, a single mobile robot replaces damaged sensors by picking up spare ones in the region of interest or carrying them from a base station in wireless sensor and robot networks. The objective is to find the shortest path of the robot. The problem is an extension of the traveling salesman problem (TSP). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215107PLOS
April 2019
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Monoclonal antibodies point to Achilles' heel in picornavirus capsid.

Authors:
Mihnea Bostina

PLoS Biol 2019 Apr 17;17(4):e3000232. Epub 2019 Apr 17.

Department of Microbiology and Immunology and Otago Micro and Nano Imaging, University of Otago, Dunedin, New Zealand.

Picornaviruses are small, icosahedral, nonenveloped, positive-sense, single-stranded RNA viruses that form one of the largest and most important viral families. Numerous Picornaviridae members pose serious health or agricultural threats, causing diseases such as poliomyelitis, hepatitis A, or foot-and-mouth disease. The antigenic characterization of picornavirus capsids plays an important role in understanding the mechanism of viral neutralization and the conformational changes associated with genome release, and it can point to regions which can be targeted by small-molecule compounds to be developed as antiviral inhibitors. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000232DOI Listing

Changing paradigm of antibiotic resistance amongst Escherichia coli isolates in Indian pediatric population.

PLoS One 2019 17;14(4):e0213850. Epub 2019 Apr 17.

Department of Microbiology, University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi, India.

Antimicrobial resistance happens when microorganisms mutates in manners that render the drugs like antibacterial, antiviral, antiparasitic and antifungal, ineffective. The normal mutation process is encouraged by the improper use of antibiotics. Mutations leading to quinolone resistance occur in a highly conserved region of the quinolone resistance-determining region (QRDR) of DNA gyrAse and topoisomerase IV gene. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213850PLOS

Expression of OX40 Gene and its Serum Levels in Neuromyelitis Optica Patients.

Biomol Concepts 2019 Apr 11;10(1):62-67. Epub 2019 Apr 11.

Isfahan Neuroscience Research Center, Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Neuromyelitis optica (NMO), also known as Devic's disease, is an autoimmune disorder of the central nervous system (CNS) in which immune system cells and antibodies primarily attack the optic nerves and the spinal cord. OX40 (CD134) is a tumor necrosis factor (TNF)-receptor family member expressed primarily on activated CD4+ and CD8+ T-cells. In an autoimmune disease, OX40 is typically up-regulated at sites of inflammation, and increases in the number of peripheral CD4+ T-cells expressing OX40. Read More

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http://dx.doi.org/10.1515/bmc-2019-0007DOI Listing

Active Textile Braided in Three Strands with Thin McKibben Muscle.

Soft Robot 2019 Apr;6(2):250-262

Department of Mechanical Engineering, Tokyo Institute of Technology, Meguro-ku, Japan.

This article presents an active textile braided in three strands with thin McKibben muscle. The fabrication of a textile using thin McKibben muscle as thread can be accomplished using a unique braiding method, developed in this study, to provide an active textile that shrinks along the transverse surface direction. This textile-type actuator is suitable as a type of soft robotic actuator for application in wearable robots and musculoskeletal robots because it is extremely lightweight, flexible, and easily applied to robot structures. Read More

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http://dx.doi.org/10.1089/soro.2018.0076DOI Listing

The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase.

Biosci Biotechnol Biochem 2019 Apr 17:1-4. Epub 2019 Apr 17.

e Department of Food Science and Nutrition , Nara Women's University , Kitauoyanishi-machi, Nara , Japan.

Rugosin G, an ellagitannin trimer, was isolated from the water-soluble fraction of red rose petals, and its inhibitory activity against recombinant human histidine decarboxylase was investigated. Rugosin G showed potent inhibition compared to ellagitannin monomers and a dimer with macrocyclic structure (oenothein B), suggesting the potent inhibition of rugosin G was attributed to its linear oligomeric conformation. Abbreviations: HDC, histidine decarboxylase; Me2CO, acetone; EtOAc, ethyl acetate. Read More

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http://dx.doi.org/10.1080/09168451.2019.1606695DOI Listing

Trends in time in the management of the implantable cardioverter defibrillator in the last phase of life: a retrospective study of medical records.

Eur J Cardiovasc Nurs 2019 Apr 17:1474515119844660. Epub 2019 Apr 17.

1 Department of Public Health, Erasmus University Medical Center Rotterdam, The Netherlands.

Background: The implantable cardioverter defibrillator (ICD) might give unwanted shocks in the last month of life. Guidelines recommend deactivation of the ICD prior to death.

Aims: The aims of this study were to examine trends in time (2007-2016) in how and when decisions are made about ICD deactivation, and to examine patient- and disease-related factors which may have influenced these decisions. Read More

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http://dx.doi.org/10.1177/1474515119844660DOI Listing

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.

JCO Clin Cancer Inform 2019 Apr(3):1-17

1 Royal College of Surgeons in Ireland, Dublin, Ireland.

Purpose: Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the profiling of multiple model inputs, which hampers clinical translation.

Patients And Methods: We applied APOPTO-CELL, a prognostic model of apoptosis signaling, to showcase the establishment of computational platforms that require a reduced set of inputs. Read More

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http://dx.doi.org/10.1200/CCI.18.00056DOI Listing

Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity.

JCO Clin Cancer Inform 2019 Apr(3):1-10

1 All authors: Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from pre-existence or by evolving new genotypes and traits. Intratumor heterogeneity serves as a reservoir for resistance, which often occurs as a result of the selection of minor cellular subclones. Read More

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http://dx.doi.org/10.1200/CCI.18.00074DOI Listing

Clinical Value of MRI in Assessing the Stability of Osteochondritis Dissecans Lesions: A Systematic Review and Meta-Analysis.

AJR Am J Roentgenol 2019 Apr 17:1-8. Epub 2019 Apr 17.

2 Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

The purpose of this study is to perform a systematic review and meta-analysis to estimate the clinical value of MRI in assessing the stability of osteochondritis dissecans (OCD) lesions. A systematic review of the literature published from January 1995 to July 2018 was performed by two independent reviewers using predefined search terms. The reference standard was established as arthroscopy or open surgery. Read More

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http://dx.doi.org/10.2214/AJR.18.20710DOI Listing

Ring-Shaped Polyoxometalates Possessing Multiple 3d Metal Cation Sites: [{M(OH)}{M(OH)}PWO(OCH)] (M = Mn, Co, Ni, Cu, Zn).

Inorg Chem 2019 Apr 17. Epub 2019 Apr 17.

Department of Applied Chemistry, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-8656 , Japan.

A ring-shaped polyoxometalate (POM), [PWO] (P8W48), formed by condensation of four hexavacant lacunary α-Dawson-type [α-PWO] units, is an attractive superlacunary compound possessing a large cavity (approximately 10 Å). Although the introduction of metal species into the cavity was attempted in aqueous media using the K/Li salt of P8W48, we encountered several challenges: excess metal species are required, and K and/or Li remain in the cavity. Therefore, controlling the number and arrangement of the introduced metal species proved difficult. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00061DOI Listing

Nanowired Bioelectric Interfaces.

Chem Rev 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry and Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.

Biological systems have evolved biochemical, electrical, mechanical, and genetic networks to perform essential functions across various length and time scales. High-aspect-ratio biological nanowires, such as bacterial pili and neurites, mediate many of the interactions and homeostasis in and between these networks. Synthetic materials designed to mimic the structure of biological nanowires could also incorporate similar functional properties, and exploiting this structure-function relationship has already proved fruitful in designing biointerfaces. Read More

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http://dx.doi.org/10.1021/acs.chemrev.8b00795DOI Listing

Identification of natural compound inhibitors against PfDXR: A hybrid structure-based molecular modeling approach and molecular dynamics simulation studies.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, Gujarat, India.

In the present contribution, multicomplex-based pharmacophore studies were carried out on the structural proteome of Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Among the constructed models, a representative model with complementary features, accountable for the inhibition was used as a primary filter for the screening of database molecules. Auxiliary evaluations of the screened molecules were performed via drug-likeness and molecular docking studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28714
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http://dx.doi.org/10.1002/jcb.28714DOI Listing
April 2019
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Radiosynthesis, radiochemical, and biological characterization of Lu-labeled diethylenetriamine penta-acetic acid.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan.

Diethylenetriamine penta-acetic acid (DTPA), when complexed with a gamma (γ)-emitter radioisotope like Tc, is used for renal function diagnosis and many other diagnostic applications. The main aim of this study was to develop a novel and versatile single-step methodology for the synthesis of a new Lu-labeled radiopharmaceutical with high radiochemical yield, which can be used for diagnostic purposes and therapeutic purposes also. The single and well-defined Lu-DTPA complex was radiochemically characterized by paper chromatography, thin-layer chromatography, high-performance liquid chromatography, and electrophoresis techniques. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28712
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http://dx.doi.org/10.1002/jcb.28712DOI Listing
April 2019
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SSDs Revisited: Part II - Practical Considerations in the Development and Use of Application Factors applied to Species Sensitivity Distributions.

Environ Toxicol Chem 2019 Apr 17. Epub 2019 Apr 17.

Data & Modeling Sciences, The Procter & Gamble Company, Mason Business Center, 8700 S. Mason-Montgomery Road, Mason, OH, USA.

Application Factors (AF) are routinely applied in the extrapolation of laboratory aquatic toxicity data to ensure protectiveness from exposure to chemicals in the natural environment. The magnitude of the AF is both a scientific and policy decision; however, in any case should be rooted in scientific knowledge so as to not be arbitrary. Information rich chemicals are often subjected to Species Sensitivity Distribution (SSD) analysis to transparently describe certain aspects of assessment uncertainty and are normally subjected to much smaller AF than screening information data sets. Read More

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http://dx.doi.org/10.1002/etc.4444DOI Listing

Utilization of prickly pear waste for baker's yeast production.

Biotechnol Appl Biochem 2019 Apr 17. Epub 2019 Apr 17.

Laboratory Reactions and Process Engineering (LRPE), UMR CNRS 7224, University of Lorraine, ENSAIA, Vandoeuvre Cedex, 54505, France.

The feasibility of baker's yeast production using fruits and peels of Opuntia ficus indica (OFI) as carbohydrate feedstock was investigated. Two response surface methodologies involving central composite face centered design (CCFD) were successfully applied. The effects of four independent variables on baker's yeast production from OFI fruit juice was evaluated using the first CCFD. Read More

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http://dx.doi.org/10.1002/bab.1753DOI Listing
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