1,058,589 results match your criteria Applied Mathematics And Mechanics-english Edition[Journal]


Intravenous cannula placement in children for induction of general anesthesia: prospective audit and identification of success factors.

Paediatr Anaesth 2020 May 28. Epub 2020 May 28.

Research Institute, BC Children's Hospital, Vancouver, Canada.

Background: Approaches to pediatric induction of anesthesia vary widely. While oral sedative premedication and inhalational induction are common, total intravenous anesthesia is becoming increasingly popular. Total intravenous anesthesia without anxiolytic premedication, which is the most commonly used technique in our hospital, requires intravenous (IV) cannula placement in an awake child. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pan.13936DOI Listing

[Successful free microvascular radial artery flap for phalloplasty in case of a persistent median artery - Retrospective analysis of 48 patients and review of the literature].

Handchir Mikrochir Plast Chir 2020 May 28. Epub 2020 May 28.

AGAPLESION MARKUS KRANKENHAUS, Akademisches Lehrkrankenhaus der Johann Wolfgang Goethe-Universität Frankfurt am Main, Klinik für Plastische, Ästhetische, Wiederherstellungs- und Handchirurgie.

Background:  Anomalies of the radial arterial system can be of importance during harvesting of a radial forearm flap. In particular when using the forearm flap for phalloplasty due to the required dimensions of the flap, sufficient arterial supply is of fundamental importance. In case of a persistent median artery perfusion conditions in the supply area of ​​the A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1150-7517DOI Listing

Initial and long-term antithrombotic therapy after left atrial appendage closure with the WATCHMAN.

Europace 2020 May 28. Epub 2020 May 28.

CardioVascular Center CVC, Seckbacher Landstraße 65, 60389 Frankfurt, Germany.

Aims: Evidence regarding post-procedural antithrombotic regimen other than used in randomized trials assessing percutaneous left atrial appendage (LAA) closure is limited. The present work aimed to compare different antithrombotic strategies applied in the real-world EWOLUTION study.

Methods And Results: A total of 998 patients with successful WATCHMAN implantation were available for the present analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/europace/euaa074DOI Listing

The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin-angiotensin system.

Eur Heart J Cardiovasc Pharmacother 2020 May 28. Epub 2020 May 28.

Vascular Medicine, Amsterdam UMC, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.

The SARS-CoV-2 pandemic is a healthcare crisis caused by insufficient knowledge applicable to effectively combat the virus. Therefore, different scientific discovery strategies need to be connected, to generate a rational treatment which can be made available as rapidly as possible. This relies on a solid theoretical understanding of the mechanisms of SARS-CoV-2 infection and host responses, which is coupled to the practical experience of clinicians that are treating patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcvp/pvaa053DOI Listing

Dynamic Light Scattering: A New Noninvasive Technology for Neonatal Heart Rate Monitoring.

Neonatology 2020 May 28:1-8. Epub 2020 May 28.

Division of Neonatology, Department of Pediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Heart rate (HR) detection in premature infants using electrocardiography (ECG) is challenging due to a low signal amplitude and the fragility of the premature skin. Recently, the dynamic light scattering (DLS) technique has been miniaturized, allowing noninvasive HR measurements with a single sensor.

Objective: The aim was to determine the accuracy of DLS for HR measurement in infants, compared to ECG-derived HR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000506771DOI Listing

Cytokine Blood Filtration Responses in COVID-19.

Blood Purif 2020 May 28:1-9. Epub 2020 May 28.

Department of Medical Equipment Technology, College of Applied Medical Science, Majmaah University, Majmaah, Saudi Arabia,

The real issue with the COVID-19 pandemic is that a rapidly increasing number of patients with life-threatening complications are admitted in hospitals and are not well-administered. Although a limited number of patients use the intensive care unit (ICU), they consume medical resources, safety equipment, and enormous equipment with little possibility of rapid recovery and ICU discharge. This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000508278DOI Listing

Effects of cold atmospheric plasma treatment on the morphological and optical properties of plasmonic silver nanoparticles.

Nanotechnology 2020 May 28. Epub 2020 May 28.

Florida International University, Miami, Florida, UNITED STATES.

The use of plasma processes in nanomaterial synthesis is limited by a lack of understanding of the effects of plasma treatment on the morphology and other properties. Here, we studied the effects of atmospheric plasma treatment on the morphology and optical properties of Ag nanoparticles. The Ag nanoparticles were deposited on substrates by injecting an aerosol into flowing argon gas and then treated with a low-temperature atmospheric plasma jet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ab9788DOI Listing

Automatic screening method for atrial fibrillation based on lossy compression of the electrocardiogram signal.

Physiol Meas 2020 May 28. Epub 2020 May 28.

Zhengzhou University, Cooperative Innovation Center of Internet Healthcare, Zhengzhou, Henan, CHINA.

Objective: Compressed sensing is a low-complexity compression technology that has recently been proposed. It can be applied to long-term electrocardiogram (ECG) monitoring using wearable devices. In this study, an automatic screening method for atrial fibrillation based on lossy compression of the electrocardiogram signal is proposed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6579/ab979fDOI Listing

Ce(OH)3 as novel negative electrode materials for supercapacitors.

Nanotechnology 2020 May 28. Epub 2020 May 28.

Changchun Institute of Applied Chemistry Chinese Academy of Sciences, Changchun, Jilin, CHINA.

Novel electrode materials with desired specific capacitances are needed for supercapacitors. Rare earth (RE)-based materials are fascinating in the field of catalysis and energy. Herein, a series of hydroxides including La, Ce, Pr and Nd was synthesized via in situ precipitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ab9787DOI Listing
May 2020
3.821 Impact Factor

Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome.

iScience 2020 May 15;23(6):101164. Epub 2020 May 15.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address:

Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically realistic preclinical model to investigate the molecular basis for the reduced postprandial thermogenesis (PPT) and develop a therapeutic strategy to normalize this deficit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.101164DOI Listing

Inclusion of seasonal variation in river system microbial communities and phototroph activity increases environmental relevance of laboratory chemical persistence tests.

Sci Total Environ 2020 Apr 30;733:139070. Epub 2020 Apr 30.

School of Life Sciences, Gibbet Hill Campus, University of Warwick, Coventry CV4 7AL, UK.

Regulatory tests assess crop protection product environmental fate and toxicity before approval for commercial use. Although globally applied laboratory tests can assess biodegradation, they lack environmental complexity. Microbial communities are subject to temporal and spatial variation, but there is little consideration of these microbial dynamics in the laboratory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139070DOI Listing

Plasmonic nanoparticles on metal-organic framework: A versatile SERS platform for adsorptive detection of new coccine and orange II dyes in food.

Food Chem 2020 May 21;328:127105. Epub 2020 May 21.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Academy of Contemporary Food Engineering, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou 510006, China; Engineering and Technological Research Centre of Guangdong Province on Intelligent Sensing and Process Control of Cold Chain Foods, & Guangdong Province Engineering Laboratory for Intelligent Cold Chain Logistics Equipment for Agricultural Products, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China; Food Refrigeration and Computerized Food Technology (FRCFT), Agriculture and Food Science Centre, University College Dublin, National University of Ireland, Belfield, Dublin 4, Ireland. Electronic address: http://www.ucd.ie/refrig.

Synthetic dyes have been widely applied to food processing, but abuse of colourants in food may pose risks to human health. To analyze new coccine (NC) and orange II (OII) in food, a versatile surface-enhanced Raman scattering (SERS) platform was proposed. A metal-organic framework (MOF, UiO-66(NH)) with octahedral crystal structure was synthesized and gold nanoparticles were grown on the MOF surface to fabricate UiO-66(NH)@Au versatile SERS platform. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127105DOI Listing

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 May 19;1149:122177. Epub 2020 May 19.

Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

A simple and rapid bioanalytical method was developed for the simultaneous quantification of irinotecan and SN-38 in mouse plasma and tissue homogenates using High-Performance Liquid Chromatography with Fluorescence detection (HPLC-FL). Camptothecin was used as internal standard and protein precipitation with acetonitrile-methanol (1:1, v/v) followed by acidification with 0.5 M hydrochloric acid was used for sample pre-treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2020.122177DOI Listing

Identification of working reindeer using palaeopathology and entheseal changes.

Int J Paleopathol 2020 May 25;30:57-67. Epub 2020 May 25.

Biodiversity Unit, University of Oulu, P.O. Box 3000, 90014, University of Oulu, Finland.

Objective: This paper explores the potential of analyzing pathological lesions and entheseal changes in the identification of working reindeer.

Methods: The skeletons of 26 modern working reindeer from Siberia and Northern Finland are analyzed for pathological lesions and entheseal changes.

Results: Working results in elevated frequencies of pathological lesions, specifically joint disease in cervical and thoracic vertebrae, humeri, os coxae and proximal phalanges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpp.2020.02.001DOI Listing

Poultry litter ash characterisation and recovery.

Waste Manag 2020 May 25;111:10-21. Epub 2020 May 25.

INSTM and Chemistry for Technologies Laboratory, Department of Mechanical and Industrial Engineering, University of Brescia, via Branze, 38, 25123 Brescia, Italy. Electronic address:

This paper reports a complete characterisation of poultry litter ash and its potential use as a heavy metal stabiliser. We propose a novel approach, in which the ashes deriving from municipal solid waste incineration (MSWI) are combined with poultry litter ash, rather than with coal combustion flue gas desulfurisation (FGD) residues. Heavy metals stabilisation was demonstrated by comparing the elemental concentrations in the leaching solutions of the starting raw and stabilised materials: leachable Pb and Zn showed a reduced solubility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wasman.2020.05.010DOI Listing

Quantification of neurons in the olfactory bulb of the catsharks Scyliorhinus canicula (Linnaeus, 1758) and Galeus melastomus (Rafinesque, 1810).

Zoology (Jena) 2020 Apr 26;141:125796. Epub 2020 Apr 26.

Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, Corso Europa, 26, 16132, Genoa, Italy. Electronic address:

In vertebrates, the olfactory bulb (OB) is the zone of the brain devoted to receiving the olfactory stimuli. The size of the OB relative to the size of the brain has been positively correlated to a good olfactory capability but, recently, this correlation was questioned after new investigation techniques were developed. Among them, the isotropic fractionator allows to estimate the number of neurons and non-neurons in a given portion of nervous tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.zool.2020.125796DOI Listing

Evaluation of hearing function in patients with lichen planus.

Med Hypotheses 2020 May 22;143:109867. Epub 2020 May 22.

Inonu University Faculty of Medicine, Department of Dermatology, Malatya, Turkey.

Lichen planus (LP) is a chronic, autoimmune, inflammatory disease. We believe that tympanic membrane and outer ear canal can be affected by the disease and since it is an autoimmune disease inner ear involvement may be seen. The aim of this study was to evaluate hearing functions in patients with LP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2020.109867DOI Listing

Can moderate intensity aerobic exercise be an effective and valuable therapy in preventing and controlling the pandemic of COVID-19?

Authors:
Snehil Dixit

Med Hypotheses 2020 May 20;143:109854. Epub 2020 May 20.

Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2020.109854DOI Listing

Estimation and correction of Cerenkov-light on luminescence image of water for carbon-ion therapy dosimetry.

Phys Med 2020 May 25;74:118-124. Epub 2020 May 25.

Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Japan. Electronic address:

Purpose: The luminescence images of water during the irradiation of carbon-ions provide useful information such as the ranges and the widths of carbon-ion beams. However, measured luminescence images show higher intensities in shallow depths and wider lateral profiles than those of the dose distributions. These differences prevent the luminescence imaging of water from being applied to a quality assurance for carbon-ion therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmp.2020.05.012DOI Listing

Speciation analysis of arsenic in edible mushrooms by high-performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry.

Food Chem 2020 May 19;327:127033. Epub 2020 May 19.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China; Provincial Key Laboratory for Food Safety Monitoring and Risk Assessment of Sichuan, Chengdu 610041, China. Electronic address:

Some varieties of edible mushrooms can accumulate high contents of arsenic, which is a public health concern. In this study, we developed a high-performance liquid chromatography method linked to inductively coupled plasma triple quadrupole mass spectrometry (HPLC-ICP-MS/MS) for sensitive and accurate determination of arsenite, arsenate, monomethylarsonic acid, dimethylarsinic acid, arsenocholine and arsenobetaine in edible mushrooms. The six arsenic species were extracted ultrasonically from mushrooms using ultrapure water at 60 °C as the solvent, separated on a PRP-X100 anion exchange column (4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodchem.2020.127033DOI Listing

A new method for three-dimensional immunofluorescence study of the cochlea.

Hear Res 2020 May 5;392:107956. Epub 2020 May 5.

Otolaryngology, Department of Surgery, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. Electronic address:

Visualisation of cochlear histopathology in three-dimensions has been long desired in the field of hearing research. This paper outlines a technique that has made this possible and shows a research application in the field of hearing protection after cochlear implantation. The technique utilises robust immunofluorescent labelling followed by effective tissue clearing and fast image acquisition using Light Sheet Microscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heares.2020.107956DOI Listing

HRM and 16S rRNA gene sequencing reveal the cultivable microbiota of the European sea bass during ice storage.

Int J Food Microbiol 2020 May 11;327:108658. Epub 2020 May 11.

Lab of Marketing and Technology of Aquatic Products and Foods, Department of Ichthyology and Aquatic Environment, School of Agricultural Sciences, University of Thessaly, Fytokou street, 38446 Volos, Greece.

The total cultivable microbiota of the ice-stored European sea bass (Dicentrarchus labrax), the most important commercial fish species of the Mediterranean aquaculture, was determined using 16S rRNA gene sequence analysis. High Resolution Melting (HRM) curve profiles and sequencing analysis (V3-V4 region of the 16S rRNA gene) were used respectively for the differentiation and identification of the collected isolates from six time intervals (day 0, 4, 8, 12, 14 and 16) while fish were stored in ice. HRM analysis differentiated the unknown microbiota in ten groups (208 isolates) and in two single isolates based on their HRM curve profiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108658DOI Listing

Development of frailty measurement tools using administrative health data: A systematic review.

Arch Gerontol Geriatr 2020 May 12;89:104102. Epub 2020 May 12.

Centre for Applied Health Economics, Griffith University, Queensland, Australia; Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

Objectives: Frailty is an increasingly common health condition and is seen more often due to the ageing population. This study reviews the evidence on the development and validation of these automated frailty measurement tools.

Design: Six databases: PubMed, EMBASE, MEDLINE, CINAHL, Scopus, and Web of Science were electronically searched. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.archger.2020.104102DOI Listing

Bureaucracies and power: Examining the medical council of India and the development of emergency medicine in India.

Soc Sci Med 2020 May 14;256:113038. Epub 2020 May 14.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205l, USA. Electronic address:

In many countries, professional councils are mandated to oversee the training and conduct of health professionals, including doctors, nurses, pharmacists and allied health workers. The proper functioning of these councils is critical to overall health system performance. Yet, professional councils are sometimes criticized, particularly in the context of low- and middle-income countries, for their misuse of power and overtly bureaucratic nature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.socscimed.2020.113038DOI Listing

Effects of concentrated poultry operations and cropland manure application on antibiotic resistant Escherichia coli and nutrient pollution in Chesapeake Bay watersheds.

Sci Total Environ 2020 May 13;735:139401. Epub 2020 May 13.

Division of Environmental Health Sciences, University of California, Berkeley School of Public Health, 2121 Berkeley Way, Berkeley, CA 94704, United States of America. Electronic address:

Manure from poultry operations is typically applied to nearby cropland and may affect nutrient loading and the spread of antibiotic resistance (ABR). We analyzed the concentrations of nitrogen and phosphorus and the occurrence of ABR in Escherichia coli (E. coli) and extra-intestinal pathogenic E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139401DOI Listing

Dynamics of bacteriophages in gut of giant pandas reveal a potential regulation of dietary intake on bacteriophage composition.

Sci Total Environ 2020 May 19;734:139424. Epub 2020 May 19.

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangdong Academy of Science, Guangzhou, China. Electronic address:

Fecal samples of cubs and adults of giant pandas were examined to determine the effects of diets on the diversity and dynamics of gut bacteriophages. Enterobacteria phage, Salmonella phage, Escherichia phage, Shigella phage, Klebsiella phage, and Lactococcus phage were found to be dominant in both cub and adult samples. Citrobacter phage, Cronobacter phage, Pectobacterium phage, Erwinia phage, Dickeya phage, Erwinia phage, Enterococcus phage, and Pseudomonas phage were more abundant in adults, while Lactococcus phage, Streptococcus phage, Lactobacillus phage, and Leuconostoc phage were more abundant in cubs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139424DOI Listing

Introduction to Modern Climate Change. Andrew E. Dessler: Cambridge University Press, 2011, 252 pp, ISBN-10: 0521173159.

Authors:
Mukhtar Ahmed

Sci Total Environ 2020 May 15;734:139397. Epub 2020 May 15.

Department of Agricultural Research for Northern Sweden, Swedish University of Agricultural Sciences, Umea, Sweden; Department of Agronomy, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan. Electronic address:

Climate change is the variability of the climate system that includes the atmosphere, the biogeochemical cycles (Carbon cycle, Nitrogen cycle and Hydrological cycle), the land surface, ice and the biotic and abiotic components of the planet earth. Significant impact of climate change is seen in the form of rise in temperature called as global warming. Carbon dioxide (CO), methane (CH), and nitrous oxide (NO) are the primary greenhouse gases (GHGs) mainly responsible for the global warming and climate change. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139397DOI Listing

First detection of SARS-CoV-2 in untreated wastewaters in Italy.

Sci Total Environ 2020 May 23;736:139652. Epub 2020 May 23.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.

Several studies have demonstrated the advantages of environmental surveillance through the monitoring of sewage for the assessment of viruses circulating in a given community (wastewater-based epidemiology, WBE). During the COVID-19 public health emergency, many reports have described the presence of SARS-CoV-2 RNA in stools from COVID-19 patients, and a few studies reported the occurrence of SARS-CoV-2 in wastewaters worldwide. Italy is among the world's worst-affected countries in the COVID-19 pandemic, but so far there are no studies assessing the presence of SARS-CoV-2 in Italian wastewaters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2020.139652DOI Listing

Chelidonine Selectively Inhibits the Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells through the EGFR-AMPK Pathway.

Pharmacol Res 2020 May 25:104934. Epub 2020 May 25.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, SAR, PR China. Electronic address:

Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR. Unfortunately, due to the secondary mutation in EGFR, eventual drug-resistance is inevitable. Therefore, to overcome the resistance, new agent is urgently required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2020.104934DOI Listing

Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes.

Pharmacol Res 2020 May 25:104935. Epub 2020 May 25.

Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China; MassDefect Technologies, NJ, 08540, USA.

Xiaokewan is a typical Traditional Chinese medicine (TCM) for diabetes and is with natural chemical constituents of lignans, flavonoids, saponins, polysaccharides, and western medicine glibenclamide. In the current study, a highly efficient system for screening hypoglycemic efficacy constituents of Xiaokewan has been developed with the integration of intelligent data acquisition, data mining, network pharmacology, and computer assisted target fishing. With the combination of background exclusion data dependent acquisition (BE-DDA) and non-targeted precise-and-thorough background-subtraction (PATBS) techniques, a novel workflow has been established for the non-targeted recognition and identification of TCM constituents in vivo, and has been applied to the exposure study of Xiaokewan in rat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phrs.2020.104935DOI Listing

Activation of SREBP-1c alters lipogenesis and promotes tumor growth and metastasis in gastric cancer.

Biomed Pharmacother 2020 May 25;128:110274. Epub 2020 May 25.

Basic Medical College, Anhui Medical University, 81 MeiShan Road, Hefei, 230032, China. Electronic address:

Purpose: Aggressively growing tumors are characterized by significant variations in metabolites, including lipids, and can involve the elevated synthesis ofde novo fatty acids.

Methods: Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based metabolomics and lipidomics were performed to compare human gastric cancer tissues and adjacent normal tissues from clinical patients. A series of cellular and molecular biological methods were applied to validate the lipidomics results. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2020.110274DOI Listing

Successive exposure to Mentha piperita L. essential oil affects the culturability and induces membrane repair in a persister epidemic Salmonella Typhimurium PT4.

Microb Pathog 2020 May 25:104264. Epub 2020 May 25.

Department of Food Engineering, Center for Technology, Federal University of Paraiba, Campus I, 58051-900, Brazil. Electronic address:

This study had as aims to evaluate the effects of successive exposures to Mentha piperita L. essential oil (MPEO) on culturability and physiological functions of Salmonella Typhimurium PT4. S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micpath.2020.104264DOI Listing

Welfare of horses from Mexico and the United States of America transported for slaughter in Mexico: Fitness profiles for transport and pre-slaughter logistics.

Prev Vet Med 2020 May 16;180:105033. Epub 2020 May 16.

Department of Animal Production & Food Science, Agri-Food Institute of Aragon (IA2), University of Zaragoza, Zaragoza, Spain.

Every year thousands of horses from Mexico and the United States of America (USA) are transported to slaughter in Mexico, but little is known about their welfare or pre-slaughter logistics. In this study, we recorded the origin, sex, age and condition of horses (121 journeys, 2648 animals) upon arrival to an abattoir in northern Mexico, including transport details. Horse welfare was measured indirectly via individual scores for body condition, coat quality, lameness, ocular and nasal discharge, as well as reactivity to a chute restraint test, all performed shortly after unloading. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prevetmed.2020.105033DOI Listing

Disinfecting non-critical medical equipment - Effectiveness of hydrogen peroxide dry mist as an adjunctive method.

Am J Infect Control 2020 May 25. Epub 2020 May 25.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:

Background: Manual disinfection of medical devices is prone to failure. Disinfection by aerosolized hydrogen peroxide might be a promising adjunctive method. We aimed to assess effectiveness of dry mist of hydrogen peroxide (HPDM) on non-critical medical equipment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajic.2020.05.016DOI Listing

Sleep disordered breathing in adults living with a Fontan circulation and CPAP titration protocol.

Int J Cardiol 2020 May 25. Epub 2020 May 25.

Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Background: Fontan-type single ventricle physiology has exquisite respiratory dependence. Obstructive sleep apnoea (OSA) and continuous positive airway pressure (CPAP) are likely to have deleterious haemodynamic consequences.

Methods: Asymptomatic and symptomatic Fontan-adults underwent diagnostic polysomnography; The overnight CPAP titration employed echocardiography and peripheral venous pressure (PVP) measurements to determine the upper limit of pressure prior to haemodynamic deterioration (> 20% rise in PVP or 20% fall in stroke volume). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2020.05.060DOI Listing

Poorly suited heart valve prostheses heighten the plight of patients with rheumatic heart disease.

Int J Cardiol 2020 May 25. Epub 2020 May 25.

Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, South Africa. Electronic address:

Rheumatic heart disease (RHD) still affects more patients globally than degenerative valve disease. The vast majority of these patients live in low- to middle-income countries. Once symptomatic, they will need heart valve surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2020.05.073DOI Listing

Correction of out-of-FOV motion artifacts using convolutional neural network.

Magn Reson Imaging 2020 May 25. Epub 2020 May 25.

Institute for Medical Imaging Technology (IMIT), School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Subject motion during MRI scan can result in severe degradation of image quality. Existing motion correction algorithms rely on the assumption that no information is missing during motions. However, this assumption does not hold when out-of-FOV motion happens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2020.05.004DOI Listing

Residual film formation after emulsion application: understanding the role and fate of excipients on skin surface.

Int J Pharm 2020 May 25:119453. Epub 2020 May 25.

Normandie Univ, France; UNILEHAVRE, FR 3038 CNRS, URCOM, EA 3221, 25 rue Philippe Lebon BP 1123, 76063 Le Havre cedex, France. Electronic address:

This study focuses on the fate of excipients contained in topical emulsions once applied on the skin. The aim was thus to develop a methodology to characterize the residue left on the skin shortly after emulsion application. To this end, both the role and the impact of the different excipients on the formation and properties of the residue left on the skin surface once a product is applied were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2020.119453DOI Listing

Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool.

Kidney Int 2020 May 25. Epub 2020 May 25.

University of Toronto, Division of Nephrology, Toronto, Canada. Electronic address:

Immunosuppression in IgA nephropathy (IgAN) should be reserved for patients at high-risk of disease progression, which KDIGO guidelines determine based solely on proteinuria 1g or more/day. To investigate if treatment decisions can be more accurately accomplished using individualized risk from the International IgAN Prediction Tool, we simulated allocation of a hypothetical immunosuppression therapy in an international cohort of adults with IgAN. Two decision rules for treatment were applied based on proteinuria 1g or more/day or predicted risk from the Prediction Tool above a threshold probability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2020.04.042DOI Listing

A systematic study on chitosan-liposome based systems for biomedical applications.

Int J Biol Macromol 2020 May 25. Epub 2020 May 25.

Division of Chemical Engineering, Konkuk University, Seoul 05029, South Korea. Electronic address:

The advent of liposome technology with its unique features has led researchers to work relentlessly on the successful development of novel drug delivery vehicles based on liposomes. But still there are some limitations of using liposomes for biomedical applications because of their poor stability that is primarily the cause of rapid leakage of drugs incorporated within the said matrices. Therefore, a considerable interest has been paid on modification of surface of liposomes by combining it with several compounds of interest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.05.192DOI Listing

Green synthesized and characterized copper nanoparticles using various new plants extracts aggravate microbial cell membrane damage after interaction with lipopolysaccharide.

Int J Biol Macromol 2020 May 25. Epub 2020 May 25.

Department of Pharmaceutics, Faculty of Pharmacy, Jinnah Sindh Medical University, Karachi, Sindh 74200, Pakistan. Electronic address:

In the present study, commercially available six plants leave extracts such as Eucalyptus camaldulensis, Azadirachta indica, Murraya koenigii, Avicennia marina, Rosa rubiginosa and Datura stramonium were utilized for the production of copper nanoparticles (CuNPs). The characterization of particles was performed by UV/Vis, TEM, SEM, EDX and FTIR spectroscopy. TEM images showed the creation of CuNPs having mean size ranged from 48 to 29 nm corresponding to different plant extracts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.05.198DOI Listing

Purification and biochemical characterization of Arabian balsam α-amylase and enhancing the retention and reusability via encapsulation onto calcium alginate/FeO nanocomposite beads.

Int J Biol Macromol 2020 May 25. Epub 2020 May 25.

University of Jeddah, Department of Chemistry, Collage of Sciences and Arts at Khulais, Jeddah, Saudi Arabia; Chemistry Department, Faculty of Applied Science, Taiz University, Taiz, Yemen. Electronic address:

In this study, Arabian balsam α-amylase was purified using the three-step purification method with 9.8-fold purification and 7% recovery. The purified α-amylase's molecular weight was 85 kDa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2020.05.176DOI Listing

Impact of various central endoscopy reading models on treatment outcome in Crohn's disease using data from the randomized, controlled, exploratory cohort arm of the BERGAMOT trial.

Gastrointest Endosc 2020 May 25. Epub 2020 May 25.

Mauriziano Hospital, Turin, Italy.

Background And Aims: Endoscopic assessment of mucosal appearance by independent central reading has become the standard method to assess Crohn's disease (CD) activity in clinical trials. Performance characteristics of various endoscopy reading models have yet to be systematically evaluated.

Methods: This substudy included patients with CD in the exploratory induction cohort of BERGAMOT (NCT02394028) randomly assigned to etrolizumab or placebo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2020.05.020DOI Listing

Constructing Multi-scale Entropy Based on the Empirical Mode Decomposition(EMD) and its Application in Recognizing Driving Fatigue.

J Neurosci Methods 2020 May 25:108691. Epub 2020 May 25.

Department of Computer, Nanchang University, Nanchang, Jiangxi 330029, China.

Background: Fatigue is one of the important factors in traffic accidents. Hence, it is necessary to devise methods to detect the fatigue and apply practical fatigue detection solutions for drivers.

New Method: This paper presents a method based on the empirical mode decomposition(EMD) of multi-scale entropy on the recorded forehead Electroencephalogram(EEG) signals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2020.108691DOI Listing

Aronia berry inhibits disruption of Caco-2 intestinal barrier function.

Arch Biochem Biophys 2020 May 25:108409. Epub 2020 May 25.

University of Wisconsin-Madison, Department of Food Science, 1605 Linden Dr., Madison, WI, 53711, USA. Electronic address:

The objective of this work was to determine how aronia berry polyphenols and its microbial catabolites improve intestinal barrier function. Caco-2 cells were cultured on transwell plates and allowed differentiate to form a model intestinal barrier, having baseline transepithelial electrical resistance (TEER) ≥ 300 Ω cm. Barrier function of differentiated Caco-2 cells was compromised by the addition of an inflammatory cocktail (IC: TNF-α, IL-1β, and IFN-γ to the basolateral media and lipopolysaccharide to the apical media). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2020.108409DOI Listing

Anatomical, morphological and growth responses of Thinopyrum ponticum plants subjected to partial and complete submergence during early stages of development.

Funct Plant Biol 2020 May 29. Epub 2020 May 29.

Seedling recruitment and growth of forage grasses in flood-prone grasslands is often impaired by submergence. We evaluate the responses of Thinopyrum ponticum (Podp.) Barkw. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1071/FP19170DOI Listing

Direct and fast screening of new psychoactive substances using medical swabs and atmospheric solids analysis probe-triple quadrupole with data-dependent acquisition.

J Am Soc Mass Spectrom 2020 May 28. Epub 2020 May 28.

New psychoactive substances (NPS) have become a serious public health problem, as they are continuously changing their structures, modifying their potency and effects on humans, and therefore novel compounds are unceasingly appearing. One of the major challenges in forensic analysis, particularly related to the problematic of NPS, is the development of fast screening methodologies that allow the detection of a wide variety of compounds in a single analysis. In this study, a novel application of the atmospheric solids analysis probe (ASAP) using medical swabs has been developed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jasms.0c00112DOI Listing

Highly Transparent Covalent Mucin Coatings Improve the Wettability and Tribology of Hydrophobic Contact Lenses.

ACS Appl Mater Interfaces 2020 May 28. Epub 2020 May 28.

A stable, good coverage of the corneal tissue by the tear film is essential for protecting the eye. Contact lenses, however, constitute a foreign body that separates the tear film into two thinner layers, which are then more vulnerable towards disruption. This effect is even more pronounced if the contact lenses possess an insufficient surface wettability, which, in addition to friction, is suggested to be linked to discomfort and damage to the ocular surface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c06847DOI Listing

The Birch Bracket Medicinal Mushroom, Fomitopsis betulina (Agaricomycetes) - Bioactive Source for Beta-Glucan Fraction with Tumor Cell Migration Blocking Ability.

Int J Med Mushrooms 2020 ;22(1):1-13

Competence Center for Applied Mycology and Environmental Studies, Department of Food Science and Nutrition, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.

Wild-grown fruiting bodies of the basidiomycete Fomitopsis betulina (Agaricomycetes, birch bracket mushroom, = Piptoporus betulinus) in different growing stages were collected and analyzed for their beta-glucan content. It could be shown that no significant difference in beta-glucan content regarding size or location of the collected fruiting bodies could be determined, but all samples displayed high values of beta-glucan in comparison to other well-known culinary or medicinal mushroom species. Furthermore, F. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1615/IntJMedMushrooms.2019033291DOI Listing
January 2020

Long-term outcome of liver transplantation for congenital extrahepatic portosystemic shunt.

Liver Transpl 2020 May 28. Epub 2020 May 28.

Department of Surgery, Kyoto University, Kyoto, Japan.

Liver transplantation (LT) may have been viewed as the "last resort" for the treatment of congenital extrahepatic portosystemic shunt (CEPS) due to advancement of imaging and interventional radiology techniques. However, some patients still require LT, and criteria for LT are yet to be determined. We conducted a national survey of cases undergoing LT for CEPS between June 1998 and August 2018 and evaluated the clinical data and outcomes with a review of previously reported cases from the English-language medical literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lt.25805DOI Listing
  • Page 1 of 21172