1,070,872 results match your criteria Applied Linguistics Review[Journal]


Melatonin metabolism, signaling, and possible roles in plants.

Authors:
Kyoungwhan Back

Plant J 2020 Jul 9. Epub 2020 Jul 9.

Department of Biotechnology, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.

Melatonin is a multifunctional biomolecule found in both animals and plants. In this review, the biosynthesis, levels, signaling, and possible roles of melatonin and its metabolites in plants is summarized. Tryptamine 5-hydroxylase (T5H), which catalyzes the conversion of tryptamine into serotonin, has been proposed as a target to create a melatonin knockout mutant showing a lesion mimic phenotype in rice. Read More

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http://dx.doi.org/10.1111/tpj.14915DOI Listing

In vitro Simulation of Periodontal Ligament in Fatigue Testing of Dental Crowns.

Eur J Dent 2020 Jul 9. Epub 2020 Jul 9.

Department of Applied Dental Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.

Objective:  Fatigue testing of restorative material has been appreciated as an appropriate method to evaluate dental restorations. This study aims to investigate the influence of periodontal ligament (PDL) simulation on fatigue and fracture tests results of zirconia crowns.

Materials And Methods:  A standard tooth preparation for all ceramic zirconia crown was made on a typodont mandibular molar. Read More

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http://dx.doi.org/10.1055/s-0040-1713953DOI Listing

Barriers to evidence-based treatment of serious burns: The impact of implicit bias on clinician perceptions of patient adherence.

J Burn Care Res 2020 Jul 10. Epub 2020 Jul 10.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham.

The underlying assumption of modern evidence-based practice is that treatment decisions made by health care providers are based solely on the best available scientific data. However, the connection between evidence informed care guidelines, and the provision of care remains ambiguous. In reality a number of contextual and non-clinical factors can also play a role, amongst which is the implicit bias that affects the way in which we approach or treat others based on irrelevant, individual characteristics despite conscious efforts to treat everyone equally. Read More

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http://dx.doi.org/10.1093/jbcr/iraa114DOI Listing

An Overview of the DSM-5 Alternative Model of Personality Disorders.

Psychopathology 2020 Jul 9:1-7. Epub 2020 Jul 9.

Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.

Authoritative classification systems for psychopathology such as the DSM and ICD are shifting toward more dimensional approaches in the field of personality disorders (PDs). In this paper, we provide a brief overview of the dimensionally oriented DSM-5 alternative model of PDs (AMPD). Since its publication in 2013, the AMPD has inspired a substantial number of studies, underlining its generative influence on the field. Read More

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http://dx.doi.org/10.1159/000508538DOI Listing

Molecular Complexity of Lymphovascular Invasion: The Role of Cell Migration in Breast Cancer as a Prototype.

Pathobiology 2020 Jul 9:1-14. Epub 2020 Jul 9.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham, United Kingdom,

Lymphovascular invasion (LVI) is associated with poor outcome in breast cancer (BC); however, its underlying mechanisms remain ill-defined. LVI in BC develops through complex molecular pathways involving not only the interplay with the surrounding microenvironment along with endothelial cells lining the lymphovascular spaces but also changes in the malignant epithelial cells with the acquisition of more invasive and migration abilities. In this review, we focus on the key features that enable tumour cell detachment from the primary niche, their migration and interaction with the surrounding microenvironment as well as the crosstalk with the vascular endothelial cells, which eventually lead to intravasation of tumour cells and LVI. Read More

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http://dx.doi.org/10.1159/000508337DOI Listing

Immunogenicity Evaluation of Chimeric Subunit Vaccine Comprising Adhesion Coli Surface Antigens from Enterotoxigenic Escherichia coli.

J Mol Microbiol Biotechnol 2020 Jul 9:1-10. Epub 2020 Jul 9.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran,

Enterotoxigenic Escherichia coli (ETEC) is the most common agent of diarrhea morbidity in developing countries. ETEC adheres to host intestinal epithelial cells via various colonization factors. The CooD and CotD proteins play a significant role in bacteria binding to the intestinal epithelial cells as adhesin tip subunits of CS1 and CS2 pili. Read More

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http://dx.doi.org/10.1159/000509708DOI Listing

Morphological and neurochemical characterisation of anterogradely labelled spinal sensory and autonomic nerve endings in the mouse bladder.

Auton Neurosci 2020 Jul 1;227:102697. Epub 2020 Jul 1.

Discipline of Human Physiology, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia. Electronic address:

The bladder is innervated by axons of sympathetic and parasympathetic efferent nerves, and by spinal afferent neurons. The objective was to characterise anatomically and immunohistochemically the terminal endings of sensory and autonomic motor nerve endings in wholemount preparations of the mouse bladder. We used both anterograde labelling of pelvic and hypogastric nerves ex vivo and anterograde labelling from lumbosacral dorsal root ganglia (DRG) in vivo in male and female mice. Read More

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http://dx.doi.org/10.1016/j.autneu.2020.102697DOI Listing

Systematic review: Soluble immunological biomarkers in advanced non-small-cell lung cancer (NSCLC).

Crit Rev Oncol Hematol 2020 May 5;153:102948. Epub 2020 May 5.

Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, Anichstraße 35, A- 6020, Innsbruck, Austria; Tiroler Krebsforschung Institut (TKFI), Innrain 66, A-6020, Innsbruck, Austria. Electronic address:

In the highly dynamic field of advanced malignancies, biomarkers from liquid samples are urgently needed to improve treatment tailoring. However, the heterogenic data lack direct comparison of assays, vectors and relevant validations are rarely found. Therefore, we classified the available studies based on three categories: Measured vectors, applied technique and detected biomarker. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102948DOI Listing

Eye tracking of smoking-related stimuli in tobacco use disorder: A proof-of-concept study combining attention bias modification with alpha-transcranial alternating current stimulation.

Drug Alcohol Depend 2020 Jul 2;214:108152. Epub 2020 Jul 2.

Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre intégré universitaire en santé et services sociaux de la Capitale-Nationale, 2325 rue de l'Université, Quebec City, QC, G1V 0A6, Canada. Electronic address:

Background: Tobacco use disorder (TUD) is characterized by the presence of an attentional bias (AB) towards smoking-related stimuli. We investigated whether combining an AB modification paradigm (ABM) with transcranial alternating current stimulation (tACS) applied over the dorsolateral prefrontal cortex (DLPFC) reduces the AB towards smoking-related stimuli, as well as craving level and impulsive choices.

Methods: In a sham-controlled, crossover preliminary study, 19 subjects with TUD received two stimulation arms: 1) active tACS (10 Hz, 2 mA, 30 min) combined with ABM and 2) sham tACS combined with ABM, in a randomized order, separated by one week. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108152DOI Listing

Ultrasonic-assisted synthesis of nano-sized metal-organic framework; a simple method to explore selective and fast Congo Red adsorption.

Ultrason Sonochem 2020 Jul 2;69:105246. Epub 2020 Jul 2.

Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14117-13116, Tehran, Islamic Republic of Iran. Electronic address:

A novel mixed linker Metal-organic Framework, [Co(NHIsoBDC)(bpfn)].DMF (TMU-69), with amide and amino functionalized spacers (bpfn = N,N'-(naphthalene-1,5-diyl)diisonicotinamide, NHIsoBDCH = 5-Aminoisophthalic acid) was synthesized through both solvothermal and ultrasonic approaches. Applying sonochemical irradiation led to ultrafast formation of Flower-shaped nanoplates of TMU-69 within 15 min with high yield while, solvothermal method takes 3 days to form the framework. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105246DOI Listing

Surface treatment and electron backscatter diffraction (EBSD) analysis of the body-centered cubic phase in Mg-Li based alloys processed by severe plastic deformation.

Authors:
Takahiro Mineta

Micron 2020 Jun 23;137:102914. Epub 2020 Jun 23.

Department of Mechanical Science and Engineering, Graduate School of Science and Technology, Hirosaki University, Hirosaki 036-8561, Japan. Electronic address:

Although electron backscatter diffraction (EBSD) analysis for Mg-Li based alloys is difficult to conduct, this technique is necessary to understand the properties of these alloys. Numerous studies have addressed the use of electron backscatter diffraction (EBSD) analysis as an effective technique for quantifying Mg-Li based alloys. However, a crystallographic orientation determination of β-Mg by EBSD has not been achieved thus far. Read More

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http://dx.doi.org/10.1016/j.micron.2020.102914DOI Listing

Palladium(II) complexes of tridentate bis(benzazole) ligands: Structural, substitution kinetics, DNA interactions and cytotoxicity studies.

J Inorg Biochem 2020 Jun 24;210:111156. Epub 2020 Jun 24.

Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Liverpool L3 3AF, UK. Electronic address:

Reactions of 2,6-bis(benzimidazol-2-yl)pyridine (L), 2,6-bis(benzoxazol-2-yl)pyridine (L), and 2,6-bis(benzothiazol-2-yl)pyridine (L) with [Pd(NCMe)Cl] in the presence of NaBF afforded the corresponding Pd(II) complexes, [Pd(L)Cl]BF, PdL; [Pd(L)Cl]BF, PdL; [Pd(L)Cl]BF, PdL; respectively, while reaction of bis[(1H-benzimidazol-2-yl)methyl]amine (L) with [Pd(NCMe)Cl] afforded complex [Pd(L)Cl]Cl, PdL. Characterisation of the complexes was accomplished using NMR, IR, MS, elemental analyses and single crystal X-ray crystallography. Ligand substitution kinetics of these complexes by biological nucleophiles thiourea (Tu), L-methionine (L-Met) and guanosine 5'-diphosphate disodium salt (5-GMP) were examined under pseudo-first order conditions. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111156DOI Listing

Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease.

Parkinsonism Relat Disord 2020 May 30;76:49-53. Epub 2020 May 30.

Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK. Electronic address:

Introduction: Functional dependency in basic activities of daily living (ADLs) is a key outcome in Parkinson's disease (PD). We aimed to define dependency in PD, using the original and MDS versions of the Unified Parkinson's Disease Rating Scale (UPDRS).

Methods: We developed two algorithms to define dependency from items of UPDRS Part 2 and MDS-UPDRS Part 2 relating to basic ADLs (feeding, dressing, hygiene and walking, and getting out of a chair). Read More

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http://dx.doi.org/10.1016/j.parkreldis.2020.05.034DOI Listing

Estimating the Consensus hepatitis C Cascade of Care among people who inject drugs in Australia: Pre and post availability of direct acting antiviral therapy.

Int J Drug Policy 2020 Jul 6;83:102837. Epub 2020 Jul 6.

The Kirby Institute, UNSW Sydney, Sydney, Australia.

Background Monitoring the hepatitis C virus (HCV) cascade of care (CoC) among people who inject drugs (PWID) is an essential component of the response to World Health Organisation's (WHO) hepatitis elimination goals. This study aimed to estimate the Consensus hepatitis C CoC among PWID using data collected in Australia prior to and after the introduction of unrestricted direct-acting antiviral (DAA) therapy in March 2016. Methods The Australian Needle Syringe Program Survey is a cross-sectional bio-behavioural surveillance system that recruits >2000 PWID annually. Read More

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http://dx.doi.org/10.1016/j.drugpo.2020.102837DOI Listing

Catalytic ozonation of bio-treated coking wastewater in continuous pilot- and full-scale system: Efficiency, catalyst deactivation and in-situ regeneration.

Water Res 2020 Jun 29;183:116090. Epub 2020 Jun 29.

School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing, 100083, PR China.

In this study, the performance of catalytic ozonation in the treatment of bio-treated coking wastewater (BCW) using pilot- and full-scale systems was investigated. Additionally, the removal efficiency of organic pollutants from BCW, the deactivation mechanism of MnCeO/γ-AlO, and backflushing optimization for in-situ catalyst regeneration, which have not been previously investigated, were analysed. Results of the 12-month pilot scale experiments showed that catalytic ozonation resulted in the effective removal of organic pollutants when backflushing was applied as an in-situ catalyst regeneration strategy. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116090DOI Listing

Does subjective health matter? Predicting overall and specific ADL disability incidence.

Arch Gerontol Geriatr 2020 Jun 30;90:104169. Epub 2020 Jun 30.

National University of Singapore, 469C Bukit Timah Road, Singapore, 259772, Singapore. Electronic address:

Background: The aims of this study were to examine the incidence of activities of daily living (ADL) and instrumental activities of daily living (IADL) disability in a national sample of community-living older adults, and to evaluate the value of baseline self-rated health (SRH) in predicting these outcomes. Additionally, we investigated whether SRH's prognostic ability extended to individual ADL/IADL components (e.g. Read More

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http://dx.doi.org/10.1016/j.archger.2020.104169DOI Listing

Accelerating high-resolution NMR of half-integer quadrupolar nuclei in solids: SPAM-MQMAS and SPAM-STMAS.

Solid State Nucl Magn Reson 2020 May 13;108:101668. Epub 2020 May 13.

Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181 - UCCS - Unit of Catalysis and Chemistry of Solids, F-59000, Lille, France; Bruker Biospin, 34 rue de l'industrie, F-67166, Wissembourg, France; RIKEN RSC NMR Science and Development Division, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa, 230-0045, Japan. Electronic address:

In solid-state NMR, multiple-quantum MAS (MQMAS) and satellite-transition MAS (STMAS) experiments are well-established techniques to obtain high-resolution spectra of half-integer quadrupolar nuclei. In 2004 and 2005, a soft-pulse-added-mixing (SPAM) concept was introduced by Gan and Amoureux to enhance the S/N ratio of MQMAS and STMAS experiments. Despite their robustness and simplicity, SPAM approaches have not yet been widely applied. Read More

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http://dx.doi.org/10.1016/j.ssnmr.2020.101668DOI Listing

Assessing population exposure to phthalate plasticizers in thirteen Spanish cities through the analysis of wastewater.

J Hazard Mater 2020 Jun 22;401:123272. Epub 2020 Jun 22.

Department of Analytical Chemistry, Institute of Research on Chemical and Biological Analysis (IAQBUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Phthalates are widely used plasticizers that produce endocrine-disrupting disorders. Quantifying exposure is crucial to perform risk assessments and to develop proper health measures. Herein, a wastewater-based epidemiology approach has been applied to estimate human exposure to six of the mostly used phthalates within the Spanish population. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123272DOI Listing

A combined abiotic oxidation-precipitation process for rapid As removal from high-As(III)-Mn(II) acid mine drainage and low As-leaching solid products.

J Hazard Mater 2020 Jul 1;401:123360. Epub 2020 Jul 1.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, China. Electronic address:

A combination process of Fenton-like and catalytic Mn(II) oxidation via molecular oxygen-induced abio-oxidation of As(III)-Mn(II)-rich acid mine drainage (AMD) is developed to rapidly and efficiently remove As and obtain low As-leaching solids in this study. The effect of pH, temperature, oxygen flow rate and neutralization reagent on As removal was investigated. The results showed that pH was important to As removal efficiency, which achieved maximum in 0. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123360DOI Listing

Ultra-stable aqueous foams induced by interfacial co-assembly of highly hydrophobic particles and hydrophilic polymer.

J Colloid Interface Sci 2020 Jun 26;579:628-636. Epub 2020 Jun 26.

Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. Electronic address:

Hypothesis: Interfacial assembly between nanoparticles and complementary ligands can in-situ generate Janus-like particles, rendering high stability of a Pickering-based system. Hence, through the self-assembly and formation of a Janus structure at the air/water interface, which is composed of a hydrophobic particle layer in the inner air phase and then a hydrophilic polymer layer in the aqueous phase, it should be possible to fabricate ultra-stable Pickering foams.

Experiments: Foams containing different highly hydrophobic particles and hydrophilic polymers or microgels were prepared, and their stability was investigated. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.098DOI Listing

Preparation of CoS supported flower-like NiFe layered double hydroxides nanospheres for high-performance supercapacitors.

J Colloid Interface Sci 2020 Jun 26;579:607-618. Epub 2020 Jun 26.

College of Materials Science and Engineering, Institute for Graphene Applied Technology Innovation, Collaborative Innovation Centre for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Qingdao University, Qingdao 266071, China; College of Material Science and Engineering, Linyi University, Linyi 276000, Shandong, China. Electronic address:

Layered double hydroxides (LDHs) are a kind of classic pseudocapacitive materials with lamellar structure and large specific surface area, which have attracted swinging attention in the electrochemical energy storage area. The CoS@Ni is synthesized through a hydrothermal process, followed by surface generation of the flower-like nickel-iron layered double hydroxide (NiFe-LDH) nanospheres through a hydrothermal process, which is directly used to design a binder-free electrode with a splendid capacitance capability. The as-synthesized NiFe-LDH@CoS@Ni electrode presents an outstanding specific capacitance of 11. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.086DOI Listing

Experimental validation of a phased array probe model in ultrasonic inspection.

Ultrasonics 2020 Jul 3;108:106217. Epub 2020 Jul 3.

GKN Aerospace Sweden AB, Flygmotorvägen 1, SE-461 81 Trollhättan, Sweden. Electronic address:

New manufacturing technologies such as additive manufacturing facilitate flexible and complex designs and production of components. However, these new techniques should not compromise the safety aspect, which imposes higher demands on the integrity insurance and inspection methods. Phased array ultrasonic testing (PAUT) provides advanced inspection and evaluation processes, whereas qualification is still needed when applied together with new manufacturing techniques. Read More

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http://dx.doi.org/10.1016/j.ultras.2020.106217DOI Listing

Human campylobacteriosis related to cross-contamination during handling of raw chicken meat: Application of quantitative risk assessment to guide intervention scenarios analysis in the Australian context.

Int J Food Microbiol 2020 Jun 30;332:108775. Epub 2020 Jun 30.

Department of Health Western Australia, 189 Royal Street, East Perth, Western Australia 6004, Australia.

Quantitative Microbiological Risk Assessment (QMRA) is a methodology used to organize and analyze scientific information to both estimate the probability and severity of an adverse event as well as prioritize efforts to reduce the risk of foodborne pathogens. No QMRA efforts have been applied to Campylobacter in the Australian chicken meat sector. Hence, we present a QMRA model of human campylobacteriosis related to the occurrence of cross-contamination while handling raw chicken meat in Western Australia (WA). Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108775DOI Listing

An injectable hydrogel with pH-sensitive and self-healing properties based on 4armPEGDA and N-carboxyethyl chitosan for local treatment of hepatocellular carcinoma.

Int J Biol Macromol 2020 Jul 6. Epub 2020 Jul 6.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan, China.

Injectable hydrogels with pH-sensitive and self-healing properties have great application potential in the field of anti-cancer drug carriers. In this work, an injectable hydrogel is prepared using 4armPEG-benzaldehyde (4armPEGDA) and N-carboxyethyl chitosan (CEC) as a new drug carrier. The gelation time, equilibrium swelling rate, degradation time, and dynamic modulus of the injectable hydrogels can be adjusted by merely changing the concentration of 4armPEGDA. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.008DOI Listing

Association of exposure to phthalates and environmental phenolics with markers of kidney function: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Environ Int 2020 Jul 6;143:105877. Epub 2020 Jul 6.

School of Public Health, Seoul National University, Seoul, Republic of Korea. Electronic address:

Increasing number of consumer chemicals have been associated with chronic kidney disease (CKD) in human populations. However, many studies that investigated estimated glomerular filtration rate (eGRF) as an outcome reported inconsistent associations. In the present study, we employed a subset (n = 1292) of a nationally representative adult population participating in Korean National Environmental Health Survey (KoNEHS) 2015-2017, and assessed associations of major phthalates, bisphenol A (BPA), and parabens with both eGRF and albuminuria. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105877DOI Listing

Establishing a terrestrial proxy based on fluorescent dissolved organic matter from sediment pore waters in the East China Sea.

Water Res 2020 Jun 11;182:116005. Epub 2020 Jun 11.

Shenzhen Key Laboratory of Marine Archaea Geo-Omics, Southern University of Science and Technology, Shenzhen, 518055, China; Department of Ocean Science & Engineering, Southern University of Science and Technology, Shenzhen, 518055, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 510000, China. Electronic address:

Terrestrial organic matter occupies an important position in the oceanic organic carbon pool. Some terrestrial proxies, like the Branched and Isoprenoid Tetraether (BIT) index, have been applied successfully to indicate the relative abundance of terrestrial organic matter in marine sediments. A new terrestrial proxy derived from sediment pore water fluorescent dissolved matter (FDOM) was developed in this study. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116005DOI Listing

Machine learning and AI-based approaches for bioactive ligand discovery and GPCR-ligand recognition.

Methods 2020 Jul 6. Epub 2020 Jul 6.

University of Wisconsin-Madison, Department of Biostatistics and Medical Informatics.

In the last decade, machine learning and artificial intelligence applications have received a significant boost in performance and attention in both academic research and industry. The success behind most of the recent state-of-the-art methods can be attributed to the latest developments in deep learning. When applied to various scientific domains that are concerned with the processing of non-tabular data, for example, image or text, deep learning has been shown to outperform not only conventional machine learning but also highly specialized tools developed by domain experts. Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.06.016DOI Listing

Free energy-based model of CTCF-mediated chromatin looping in the human genome.

Methods 2020 Jul 6. Epub 2020 Jul 6.

Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Banacha 2c, Warsaw 02-089, Poland; Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland. Electronic address:

In recent years, high-throughput techniques have revealed considerable structural organization of the human genome with diverse regions of the chromatin interacting with each other in the form of loops. Some of these loops are quite complex and may encompass regions comprised of many interacting chain segments around a central locus. Popular techniques for extracting this information are chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) and high-throughput chromosome conformation capture (Hi-C). Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.05.025DOI Listing

In vitro and in vivo assessment of phage therapy against Staphylococcus aureus causing bovine mastitis.

J Glob Antimicrob Resist 2020 Jul 6. Epub 2020 Jul 6.

Bacteriology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine and Institute for Fundamental and Applied Research in Animals and Health (FARAH), University of Liège, quartier vallée 2, avenue Cureghem 6, B-4000, Liège, Belgium. Electronic address:

Objectives: The aim of this study was to assess the efficacy of lytic bacteriophages onStaphylococcus aureus causing bovine mastitis, by in vitro and in vivo assays using Galleria mellonella and murine mastitis models.

Methods: Between May and December 2016, tenS. aureus (five methicillin-resistant and five methicillin-sensitive) isolates were isolated from milk samples of cattle with mastitis in Belgium and Norway. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.06.020DOI Listing

Analysis of Hashimoto's thyroiditis on fine needle aspiration samples by MALDI-Imaging.

Biochim Biophys Acta Proteins Proteom 2020 Jul 6:140481. Epub 2020 Jul 6.

Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, ASST, Monza, Italy. Electronic address:

Matrix-Assisted Laser Desorption/Ionization (MALDI)- Mass Spectrometry imaging (MSI) has been applied in various diseases aimed to biomarkers discovery. In this study diagnosis and prognosis of Hashimoto Thyroiditis (HT) in cytopathology by MALDI-MSI has been investigated. Specimens from a routine series of subjects who underwent UltraSound-guided thyroid Fine Needle Aspirations (FNAs) were used. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140481DOI Listing

Photodynamic Inactivation using a Chlorin-Based Photosensitizer with Blue or Red-Light Irradiation against Single-species Biofilms related to Periodontitis.

Photodiagnosis Photodyn Ther 2020 Jul 6:101916. Epub 2020 Jul 6.

Department of Diagnosis and Surgery, São Paulo State University (Unesp), School of Dentistry, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil. Electronic address:

Chlorin-e6 (Ce6), as a photosensitizer (PS), has demonstrated significant reduction of microorganisms' viability when irradiated by red light. However, the main absorption peak of this PS is located at blue light spectrum, never investigated. This study aimed to evaluate the effect of pure-chlorin-e6-mediated photodynamic inactivation (PDI) using different light sources (450 or 660 nm) against biofilms related to periodontitis. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101916DOI Listing

Heavy metal contamination in recorded and unrecorded spirits. Should we worry?

Regul Toxicol Pharmacol 2020 Jul 6:104723. Epub 2020 Jul 6.

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary. Electronic address:

Heavy metals can be released into all alcoholic beverages during production and storage. However, there is at least a theoretical risk that they could be present in higher, and potentially toxic, concentrations in those produced in the household and small-scale stills common in Central and Eastern Europe, which lack quality control and whose products are unrecorded by authorities. Yet, so far, few studies comparing concentrations of heavy metals in recorded and unrecorded spirits have been published. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104723DOI Listing

Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.

Mol Cell 2020 Jul 4. Epub 2020 Jul 4.

Department of Biology, Stanford University, Stanford, CA, USA. Electronic address:

Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches for SLiM discovery to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca-activated phosphatase that recognizes LxVP and PxIxIT motifs. In vitro proteome-wide detection of CN-binding peptides, in vivo SLiM-dependent proximity labeling, and in silico modeling of motif determinants uncovered unanticipated CN interactors, including NOTCH1, which we establish as a CN substrate. Read More

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http://dx.doi.org/10.1016/j.molcel.2020.06.029DOI Listing

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS.

Cell 2020 Jun 28. Epub 2020 Jun 28.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 101408, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor-binding domain (RBD) is an attractive vaccine target but is undermined by limited immunogenicity. We describe a dimeric form of MERS-CoV RBD that overcomes this limitation. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.035DOI Listing

Single-and repeat-dose toxicity of HM10760A, a long-acting erythropoietin, in rats and monkeys.

Toxicol Appl Pharmacol 2020 Jul 6:115126. Epub 2020 Jul 6.

Biotherapeutics and Glycomics Laboratory, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea. Electronic address:

Anemia is a frequent complication of chronic kidney disease (CKD) that causes an increase in morbidity and mortality and accelerates the rate of disease progression. Treatment with recombinant human erythropoietin (rhEPO) is a major breakthrough in the therapy of renal anemia. HM10760A, a long-acting EPO, has been developed as a treatment for anemia in CKD patients. Read More

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http://dx.doi.org/10.1016/j.taap.2020.115126DOI Listing

Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models.

Mol Ther 2020 Jun 27. Epub 2020 Jun 27.

Imaging Therapies and Cancer Group, Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. Electronic address:

Chimeric antigen receptor T cell therapy (CAR-T) has been rolled out as a new treatment for hematological malignancies. For solid tumor treatment, CAR-T has been disappointing so far. Challenges include the quantification of CAR-T trafficking, expansion and retention in tumors, activity at target sites, toxicities, and long-term CAR-T survival. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.06.028DOI Listing

A Strategy for the Construction of Triply Interlocked Organometallic Cages by Rational Design of Poly-NHC Precursors.

J Am Chem Soc 2020 Jul 9. Epub 2020 Jul 9.

Three-dimensional (3D) triply interlocked catenanes are a family of chemical topologies that consist of two identical, mechanically interlocked coordination cage components with intriguingly complex structures. Although only a few successful constructions of 3D interlocked catenanes have been achieved to date via metal-mediated assembly, these complex structures have thus far only been targeted by metal-nitrogen/oxygen coordination techniques. Here, taking advantage of rational ligand design, we report the efficient construction of a series of 3D triply interlocked [2]catenanes of the formula [Ag3L2]2, wherein the metal ions exclusively form bonds to N-heterocyclic carbene (NHC) units, and their subsequent transmetalation to the corresponding [Au3L2]2 gold analogues. Read More

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http://dx.doi.org/10.1021/jacs.0c06470DOI Listing

Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore , improves telogen effluvium-associated parameters.

J Cosmet Dermatol 2020 Jul 9. Epub 2020 Jul 9.

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

Objective: Human hair follicles (HFs) express the olfactory receptor OR2AT4, which is selectively stimulated by the synthetic sandalwood-like odorant, Sandalore . In organ-cultured, human scalp HFs, Sandalore prolongs anagen, and suppresses apoptosis by up-regulating intra-follicular IGF-1 mediated signalling. The objective of this study is to demonstrate whether effects of Sandalore observed ex vivo translate into a clinically relevant effect in patients with telogen effluvium. Read More

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http://dx.doi.org/10.1111/jocd.13608DOI Listing
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