927,119 results match your criteria Applied Immunohistochemistry & Molecular Morphology[Journal]
Mol Ecol Resour 2018 Dec 16. Epub 2018 Dec 16.
Museum of Southwestern Biology and Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, New Mexico, 87131-0001, USA.
Avian malaria and related haemosporidians (Plasmodium, [Para]Haemoproteus, and Leucocytoozoon) represent an exciting multi-host, multi-parasite system in ecology and evolution. Global research in this field accelerated after 1) the publication in 2000 of PCR protocols to sequence a haemosporidian mitochondrial (mtDNA) barcode, and 2) the development in 2009 of an open-access database to document the geographic and host ranges of parasite mtDNA haplotypes. Isolating haemosporidian nuclear DNA from bird hosts, however, has been technically challenging, slowing the transition to genomic-scale sequencing techniques. Read More
J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.
College of Nursing, The Catholic University of Korea, Seoul, Republic of Korea.
Aims And Objectives: The purpose of this study was to analyze the operation, anesthesia, and recovery related factors affecting the occurrence of delirium in the intensive care unit.
Background: The occurrence rate of postoperative delirium is high in surgical patients. Postoperative delirium most frequently occurs usually within 3 days after an operation. Read More
Med Phys 2018 Dec 16. Epub 2018 Dec 16.
Department of Radiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Purpose: Contrast-enhanced ultrasound imaging (CEUS) has expanded the diagnostic potential of ultrasound by enabling real-time imaging and quantification of tissue perfusion. Several perfusion models and curve fitting methods have been developed to quantify the temporal behavior of tracer signal and standardize perfusion quantification. While the least-squares approach has traditionally been applied for curve-fitting, it can be inadequate for noisy and complex data. Read More
Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126, Milan, Italy.
The past few years observed a breakthrough of genome sequences of bacteria of Rhodococcus genus with significant biodegradation abilities. Invaluable knowledge from genome data and their functional analysis can be applied to develop and design strategies for attenuating damages caused by hydrocarbon contamination. With the advent of high-throughput -omic technologies, it is currently possible to utilize the functional properties of diverse catabolic genes, analyze an entire system at the level of molecule (DNA, RNA, protein, and metabolite), simultaneously predict and construct catabolic degradation pathways. Read More
Inflammation 2018 Dec 15. Epub 2018 Dec 15.
Department of Cardiology, Zhejiang Hospital, 12 Lingyin Road, Zhejiang, Hangzhou, China.
The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related to inflammatory suppression. JWH-133 was used for the activation of CB2R. Read More
Inflammation 2018 Dec 15. Epub 2018 Dec 15.
College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.
Oxidative stress and inflammation play an important role in the chronic kidney disease associated with obesity. Resveratrol (RSV) has been reported to exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties. The objective of the present study was to investigate the effects of RSV on renal inflammation and oxidative stress in obese mice induced by high-fat diet. Read More
Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.
Department of Otorhinolaryngology, University Hospital Duesseldorf, Duesseldorf, Germany.
Purpose: With the increasing use of new minimally invasive approaches in temporal bone surgery, the need arises for evaluation of the risk of injury to sensitive anatomical structures. The factors that influence the measurement uncertainty (variation in representation of position and shape of anatomical structures) of imaging are of relevance. We investigate the effect of patients' anatomy on the measurement uncertainty of medical CT. Read More
Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.
Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
Purpose: To provide up-to-date and detailed normative data based on a large-scale sample, increasing diagnostic validity by reference to narrow age groups as previous normative values were based upon smaller sample sizes-especially in the group of older subjects.
Method: Data were obtained from 9139 healthy subjects (4928 females aged 5-96 years and 4211 males aged 5-91 years). The standard "Sniffin' Sticks" test was applied, comprising threshold (T), discrimination (D) and identification (I) subtests, and yielding a TDI sum score. Read More
Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.
Vita-Salute San Raffaele University, Milan, Italy.
Objective: The hexanucleotide repeat expansion in C9orf72 is an associated genetic cause in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In the "ALS/FTD" spectrum prevails clinical heterogeneity and an in vivo knowledge of the underling brain dysfunction in patients carrying C9orf72 mutation remain limited and only described at group level. The study aimed to assess the brain metabolic alterations characterizing patients with C9orf72 mutation using FDG-PET in single individuals. Read More
Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.
Department of Diagnostics and Applied Technology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
People with epilepsy often suffer psychiatric symptoms or exhibit maladaptive personality characteristics which can impact them more than seizures. This case illustrates a selective association of a Theory of Mind dysfunction, including an impaired comparison of reality and others' behavior, with an obsessive-compulsive personality disorder in a patient with left temporal lobe epilepsy and crossed cognitive functions. The patient revealed visual memory deficits and impaired interpretation of other people's behavior, mental rigidity, and a tendency to formulate inflexible judgements. Read More
Mikrochim Acta 2018 Dec 15;186(1):21. Epub 2018 Dec 15.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, People's Republic of China.
The authors describe a simplified chemical precipitation method and silver mirror reaction to synthesize a nanocomposite consiting of silver nanoparticles on a thin and porous nickel oxide film. Placed on a glassy carbon electrode (GCE), it allows for the determination of levofloxacin (LEV) via square wave voltammetry (SWV). Under optimal detection conditions, the voltammetric signal (typically measured at around 0. Read More
Neotrop Entomol 2018 Dec 15. Epub 2018 Dec 15.
Agricultural Defense Agency of Bahia, Salvador, BA, Brasil.
Diaphorina citri Kuwayama (Hemiptera: Liviidae), named as Asian citrus psyllid (ACP), is the vector of the bacterium associated with huanglongbing (HLB), the most destructive citrus disease. The use of citrus flushing and ACP monitoring tools is essential for the knowledge of the occurrence pattern of cycles of both and for the improvement of the ACP management. During 3 years, 20 branches from 20 trees were evaluated for vegetative flushing, ACP abundance, and occupation in tree and branches in a Brazilian citrus area free for HLB. Read More
Clin Oral Investig 2018 Dec 15. Epub 2018 Dec 15.
Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Objectives: Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis. Read More
Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.
Ministry of Education and Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang, 330045, China.
Greenhouse gas emissions from agricultural soils contribute substantially to global atmospheric composition. Nitrous oxide (NO) is one important greenhouse gas induces global warming. Nitrification inhibitors (NI) or biochar can be effective soil NO emission mitigation strategies for agricultural soils. Read More
Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.
Department of Agricultural Biotechnology, Assam Agricultural University, Jorhat, Assam, India.
In this paper we report the isolation and taxonomic characterization of exopolysaccharide (EPS) producing bacteria followed by the role of EPS in conferring acid tolerance to the soil bacteria Bacillus amyloliquefaciens p16. The role of EPS in promoting soil aggregation is also presented. A total of 75 isolates were tested for acid tolerance and biofilm production under acid stress of which, 54 isolates were further tested for EPS production. Read More
J Fluoresc 2018 Dec 15. Epub 2018 Dec 15.
Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit, 80832, Mauritius.
Comparative study of nonlinear optical properties of red fluorescent coumarins was carried out with density functional theory based ab initio method using the popular global hybrid (GH) and range separated hybrid (RSH) functionals and correlated with the spectroscopic values. The GHs - M06 L, PBE1PBE, M06, BHHLYP, M062X and M06HF and RSHs - HISSbPBE, wB97, wB97X, HSEH1PBE, CAM-B3LYP and wB97XD in combination with the double zeta basis function 6-311 + G(d,p) were used. The computed polarizability (α), hyperpolarizability of the first order (β) and second order (γ) computed by the RSHs are closer to the spectroscopic values compared to GHs. Read More
Int J Clin Oncol 2018 Dec 15. Epub 2018 Dec 15.
Department of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.
Background: Genetic polymorphisms of Toll-like receptors play important roles in gastric carcinogenesis. The aim of this study was to determine the role of TLR2-196 to -174 ins/del polymorphism in gastric cancer susceptibility and prognosis.
Methods: This study included 520 people from southern China. Read More
Osteoporos Int 2018 Dec 15. Epub 2018 Dec 15.
Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Fracture risk scores generated from population-based administrative healthcare data showed comparable or better discrimination than the Fracture Risk Assessment Tool (FRAX) scores computed without bone mineral density for predicting incident major osteoporotic fracture. Administrative data may be useful to identify individuals at high fracture risk at the population level.
Purpose: To evaluate the discrimination of fracture risk scores defined using inputs available from administrative data for predicting incident major osteoporotic fracture (MOF) and hip fracture (HF) alone. Read More
Ann Ig 2019 Jan-Feb;31(1):45-51
Discipline of Nutrition and Dietetics, The University of Auckland, New Zealand.
Background: The intervention "Med-Anticancer Food Program" has proven to be effective in promoting the Mediterranean Diet, significantly increasing the Mediterranean Adequacy Index in healthy subjects. There are no studies that have investigated the effectiveness of this intervention in individuals who have had a diagnosis of cancer.
Objective: To perform a pilot study to assess the opportunity of employing the methodology of the Med-Anticancer Food Program in order to encourage "long-term cancer survivors" to adhere to the Mediterranean Diet, as well as healthy people, and this in order to apply the program to larger groups. Read More
Eur Surg Res 2018 Dec 14;59(5-6):380-390. Epub 2018 Dec 14.
Background: With aging populations increasing in developed countries, the prevalence of elderly patients with hepatocellular carcinoma (HCC) is expected to rise. The aim of this study was to determine the short- and long-term outcomes of HCC surgery in elderly patients (≥75 years) using propensity score matching.
Methods: The study group included 421 patients who underwent hepatectomy as their initial treatment with curative intent. Read More
Obes Facts 2018 Dec 14;11(6):514-523. Epub 2018 Dec 14.
Integrated Research and Treatment Center (IFB) AdiposityDiseases, University Hospital Leipzig, Leipzig, Germany.
Objectives: Identifying the underlying pathways between obesity and depression and which individuals with obesity are at risk for developing depressive symptoms is important for improving prevention and treatment efforts. The current study investigated appearance evaluation as a potential mediator of the relationship between obesity and depression.
Methods: A total of 1,000 participants with a self-reported BMI greater than 30 kg/m2 were interviewed about their experiences with an elevated body weight and completed measures on appearance evaluation and depression. Read More
Dermatology 2018 Dec 14:1-6. Epub 2018 Dec 14.
Background: Reflectance confocal microscopy (RCM) is a noninvasive technique that provides real-time in vivo images of the epidermal layer. Imiquimod has been recommended as an alternative treatment in lentigo maligna (LM) when surgical excision is not the treatment of choice. In the present study we compare the results of in vivo RCM to the histopathological examination before and after treatment of LM with topical imiquimod. Read More
J Neurosurg 2018 Dec 14:1-12. Epub 2018 Dec 14.
OBJECTIVEDeep brain stimulation (DBS) is an effective procedure in improving motor symptoms for patients with advanced Parkinson's disease (PD) through the use of high-frequency stimulation. Although one of the most commonly used target sites for DBS, sensorimotor regions of the globus pallidus interna (GPi) have yet to be thoroughly described with advanced neuroimaging analysis in vivo for human subjects. Furthermore, many imaging studies to date have been performed in a research setting and bring into question the feasibility of their applications in a clinical setting, such as for surgical planning. Read More
Tob Control 2018 Dec 15. Epub 2018 Dec 15.
Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Korea.
Background: The prevalence of cigarette smoking among South Korean adolescents has decreased markedly over the past decade, which may indicate a norm shift between generations of adolescents. The present study aims to identify the effect of banning smoking in public places and increasing cigarette prices on current adolescent smoking, and to determine whether these policies additionally resulted in cohort effects.
Methods: Repeated cross-sectional survey data, nationally representative of South Korean adolescents, were used. Read More
Biomed Pharmacother 2018 Dec 13;110:825-833. Epub 2018 Dec 13.
Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, Jilin, 130021, China. Electronic address:
Background: The long noncoding RNA colorectal neoplasia differentially expressed (CRNDE) was reported to be involved in the initiation and development of multiple cancers. However, the detailed biological role of CRNDE in non-small cell lung cancer (NSCLC) remains largely unclear. Herein, we aimed to explore the biological function and underlying molecular mechanism of CRNDE in NSCLC. Read More
Biomed Pharmacother 2018 Dec 13;110:748-757. Epub 2018 Dec 13.
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Research Centre of Excellent, Nutrition and Non-Communicable Diseases (NNCD), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia; Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address:
Manilkara zapota (L.) P. Royen (Family: Sapotaceae), commonly called as sapodilla, has been applied as traditional folk medicine for diarrhea and pulmonary infections. Read More
Psychiatry Res 2018 Dec 7;271:541-547. Epub 2018 Dec 7.
Unitat de Psiquiatria i Psicologia Mèdica, Facultat de Medicina, Universitat de València, Avda. Blasco Ibáñez 15, València E. 46010, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM); Hospital Clínico Universitario de Valencia . Instituto de Investigación Sanitaria (INCLIVA).
In this study an anger induction laboratory task was applied to men with schizophrenia, and resulted in significant changes in different psychophysiological parameters that were measured in a pre-post design. We observed a significantly greater self-reported anger mood and negative affection, lower self-reported positive affection, an increase in cardiovascular reactivity (with blood pressure in deeper affection compared to controls), higher salivary testosterone levels, lower salivary cortisol levels, and an increase in right ear items reported in dichotic listening. Furthermore, clinical risk factors related to anger in our patients were analyzed by Stepwise Regression analyses. Read More
J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 8;1105:15-25. Epub 2018 Dec 8.
Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:
A simple, sensitive and selective high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed and validated for simultaneous determination and pharmacokinetic study of 15 active compounds (Saikosaponin A, Baicalin, Wogonin, Glycyrrhizic acid, Glycyrrhetinic acid, Albiflorin, Paeoniflorin, Liquiritin, Isoliquiritin, Liquiritigenin, Isoliquiritigenin, Cinnamic acid, Gallic acid, Wogonoside and Oroxylin A) in rat plasma. After a feasible protein precipitation using methanol for sample preparation, chromatographic separation was carried out with a Halo® C column (2.1 × 100 mm, 2. Read More
J Mol Graph Model 2018 Dec 7;87:211-219. Epub 2018 Dec 7.
Theoretical & Computational Chemistry Group, Department of Chemistry, Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India. Electronic address:
Binding of four DNA nucleotide units with (ZnO) cluster in an aqueous phase has been investigated using density functional theory (DFT) and time dependent-density functional theory (TDDFT) method and the stability order for (ZnO)-nucleobases/sugar/phosphate systems is predicted as phosphate > C > A > S > T ∼ G. The order of binding energy for (ZnO)-nucleotide hybrid systems is observed to be (ZnO) + nuc-C ˃ (ZnO) + nuc-A ˃ (ZnO) + nuc-G ˃ (ZnO) + nuc-T. The binding of nucleotide units with the cluster has been explained on the basis of molecular electrostatic potential (MEP) plots, hydrogen bonding, glycosidic torsion angles, density of state (DOS) plots. Read More
Accid Anal Prev 2018 Dec 13;123:282-290. Epub 2018 Dec 13.
MOE Key Laboratory of Urban, Transportation Complex System Theory and Technology, Beijing Jiaotong University, Beijing 100044, PR China. Electronic address:
Situational discomfort awareness plays an important role in decision making among drivers and has rarely been discussed in detail in previous research. An instrumented vehicle was used to collect car-following data from multiple drivers, thereby quantitatively examining situational discomfort grading patterns using a new discomfort grading method and the latent Dirichlet allocation model. In this process, the gas pedal data and speed difference data are particularly involved in the computation for providing broader meaning to discomfort and building more comprehensive situations. Read More
J Magn Reson 2018 Dec 6;299:33-41. Epub 2018 Dec 6.
MRI Research Center, Department of Physics, University of New Brunswick, 8 Bailey Drive, Fredericton, NB E3B 5A3, Canada. Electronic address:
T relaxation time measurement is a powerful tool to distinguish signal components in porous media. As T weighting is generally achieved by spin-echo based methods, it is very challenging to capture very short T relaxation time components, approximately 1 ms, with high resolution spatial encoding. It is especially challenging when T relaxation times of the other signal components are not known a priori. Read More
J Environ Manage 2018 Dec 13;233:30-38. Epub 2018 Dec 13.
The Nature Conservancy, Arlington, VA, USA.
A central challenge in the Mississippi River Basin is how to continue to support profitable agricultural production, provide water supply, flood control, transportation, and other benefits, while reducing the current burden of environmental degradation. Several practices have been shown to reduce nutrient runoff and water pollution, and improve soil fertility, while often yielding profits for farmers. Yet many of these beneficial practices remain underutilized. Read More
Colloids Surf B Biointerfaces 2018 Dec 7;175:358-364. Epub 2018 Dec 7.
Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, PR China; Key Laboratory of Biomedical Photonics (HUST), Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, PR China. Electronic address:
In this work, a label-free Ag nanocluster (AgNC)-based fluorescent probe is proposed to detect tumor marker, prostate-specific antigen (PSA). In the experiments, DNA sequences containing segments complemented to different parts of PSA aptamer were used to synthesize DNA-Ag nanoclusters (DNA-AgNC). Some of the obtained specific DNA-AgNC exhibited significant fluorescence increase after hybridization with PSA aptamer. Read More
Adv Colloid Interface Sci 2018 Dec 7;264:1-10. Epub 2018 Dec 7.
Department of Chemical Engineering, Illinois Institute of Technology, Chicago, IL, 60616, United States.
When an air bubble or an oil droplet in a nanofluid (liquid containing dispersed nanoparticles) approaches a solid surface, a nanofluid film is formed between the bubble or drop and a solid substrate. The nanoparticles confined in the film surfaces tend to self-layer and the film thins in a stepwise manner. The wetting behavior and film stability criteria valid for the classical molecularly thin films cannot be applied to nanofilm. Read More
Musculoskelet Sci Pract 2018 Dec 1;39:101-106. Epub 2018 Dec 1.
Centre for Applied Research in Health, University of Huddersfield, HD1 3DH, UK; South West Yorkshire Partnership NHS Foundation Trust, UK.
Background: The Back-Pain Attitudes (Back-PAQ) questionnaire measures back beliefs across 6 domains. Our previous study showed that manual handling advisors (MHAs) have more negative beliefs than physiotherapists (PTs), and those who think straight back lifting is safer than a rounder back have more negative beliefs. However, exactly which domains of the Back-PAQ are most negative is unknown. Read More
J Pharm Biomed Anal 2018 Dec 10;165:207-212. Epub 2018 Dec 10.
Department of Experimental Medicine, University of Campania "L. Vanvitelli", Via S. M. di Costantinopoli, 16, 80138, Naples, Italy.
An innovative complementary approach using a liquid chromatographic-mass spectrometer method and infrared spectroscopy is proposed for measuring internal biological exposure to dangerous chemical contaminants and for monitoring biochemical changes in target organs. The proposed methodologies were validated and applied in the case of rats exposed to low-doses of Bisphenol A (BPA). A liquid chromatographic method coupled to a tandem mass spectrometer was used in order to measure BPA concentration in rat livers. Read More
J Plant Physiol 2018 Nov 29;232:320-333. Epub 2018 Nov 29.
Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:
Potassium (K) is one of the most important mineral nutrients required for fruit growth and development and is known as a 'quality element'. To investigate the role of K in more detail, we performed experiments in which seven-year-old pot-grown 'Huangguan' pear trees were treated with three levels of K (0, 0.4, or 0. Read More
Int J Pharm 2018 Dec 13. Epub 2018 Dec 13.
Institute of Pharmacy, Faculty I of Natural Sciences, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle/Saale, Germany. Electronic address:
Polymers functionally contribute to supersaturation and precipitation inhibition of the active pharmaceutical ingredient (API) in amorphous solid dispersions (ASD). Therefore, it is necessary to monitor physicochemical changes of the polymeric carrier caused by the manufacturing process. This is especially important when the material is exposed to heat and shear stress as in case of hot-melt extrusion (HME). Read More
Physiol Behav 2018 Dec 13. Epub 2018 Dec 13.
Behavior & Welfare Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; Brain Center Rudolf Magnus, Utrecht University, Utrecht, The Netherlands.
Breeding sows are regularly exposed to on-farm stressors throughout the duration of their production period. The impact of such stressors may differ for primi- and multiparous sows, as sows could learn to cope with stressors as they gain experience with them. If parity affects stress in sows, it may also impact their prenatal offspring through differential maternal stress. Read More
Food Chem Toxicol 2018 Dec 13. Epub 2018 Dec 13.
Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA, 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 93771, USA. Electronic address:
Evaluating the biological significance of human-relevant exposures to environmental estrogens involves assessing the individual and total estrogenicity of endogenous and exogenous estrogens found in serum, for example from biomonitoring studies. We developed a method for this assessment by integrating approaches for (i) measuring total hormone concentrations by mass spectrometry (Fleck et al., 2017), (ii) calculating hormone bioavailable concentrations in serum and, (iii) solving multiple equilibria between estrogenic ligands and receptors, and (iv) quantitatively describing key elements of estrogen potency. Read More
Neurosci Lett 2018 Dec 13. Epub 2018 Dec 13.
State University of Londrina, Robert Koch Av., 60, Londrina, Paraná, Brazil. Electronic address:
Background: Transcranial direct current stimulation (tDCS) is an appropriate treatment for Parkinson's disease (PD). It offers promising results and is known to improve symptoms. Nevertheless, consistent parameters need to be established for research purposes. Read More
J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Electronic address:
The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MNs-pretreated mucosa, due to their insufficient thickness. Read More
Cardiovasc Revasc Med 2018 Dec 4. Epub 2018 Dec 4.
Department of cardiology, Keio University School of Medicine, Tokyo, Japan.
Objectives: We aimed to assess real-world clinical outcomes of transcatheter aortic valve replacement (TAVR) in Japan.
Background: Data are limited concerning procedural safety and valve performance following TAVR in Japanese. A program by an on-site proctor and procedure screening system was applied during TAVR introduction. Read More
Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.
Multiphase Flow Systems (MPS), Institute of Process Engineering, Otto-von-Guericke-University (OvGU) Magdeburg, Zeppelinstraße 1, D-06130 Halle (Saale), Germany.
For about 15 years the performance of dry powder inhalers (DPIs) has been numerically analysed through CFD (computational fluid dynamics) approaches with the objective of understanding the evolving flow structures and the resulting transport of drug particles. Naturally the main interest is the numerical prediction of the emitted fine particle fraction (FPF) which is able to penetrate the lung airways. Due to the mostly used drug formulations (i. Read More
Prog Cardiovasc Dis 2018 Dec 13. Epub 2018 Dec 13.
Internal Medicine-Obesity Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA, USA; Internal Medicine-Primary Care, San Mateo County Health System, San Mateo, CA, USA.
The primary focus of public health recommendations related to the prevention of food-related chronic disease has been on the adoption of healthy dietary patterns; however, implementation has been challenging. There has been increasing recognition that an individual's diet and environment may impact disease susceptibility by affecting the expression of genes involved in critical metabolic pathways. Precision nutrition (PN) has emerged to translate discoveries about diversity in nutrient metabolism between subgroups and the inter-individual variability in the responses to dietary interventions. Read More
Anal Biochem 2018 Dec 13. Epub 2018 Dec 13.
Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Electronic address:
Glycoproteins play a central role in diverse biological processes and are linked with many serious human diseases. In this paper we present a simple, reproducible and cost-effective analytical workflow that enables the reliable quantification of clinically relevant human plasma glycoproteins using label free microflow LC-MS/MS analysis. Plasma N-glycoproteins were selectively extracted via ConA Sepharose lectin affinity chromatography then separated into two fractions using reversed-phase solid phase extraction. Read More
Prog Biophys Mol Biol 2018 Dec 13. Epub 2018 Dec 13.
Department of Biological Sciences, National University of Singapore, 117543, Singapore. Electronic address:
Viruses are metastable macromolecular assemblies that toggle between multiple conformational states through molecular rearrangements that are critical for mediating viral host entry. Viruses respond to different host specific environmental cues to form disassembly intermediates for the eventual release of genomic material required for replication. Although static snapshots of these intermediates have been captured through structural techniques such as X-ray crystallography and cryo-EM, the mechanistic details of these conformational rearrangements underpinning viral metastability have been poorly understood. Read More
Dig Liver Dis 2018 Nov 28. Epub 2018 Nov 28.
Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:
Significant advancements in the diagnosis and treatment of chronic hepatitis C infection and its associated fibrosis have revolutionized treatment of these patients over the last several years. Liver biopsy, the gold standard diagnostic method for evaluating liver fibrosis level, was routinely used prior to initiation of hepatitis C therapy, placing patients at an inherent risk of adverse events. The recent advent of noninvasive serologic and nonserologic measures of hepatic fibrosis level has reduced the need for liver biopsy significantly, thereby minimizing its associated risks. Read More
Bioorg Med Chem Lett 2018 Dec 10. Epub 2018 Dec 10.
Laboratory of Antiinfectives, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, PR China. Electronic address:
To explore the application of photoremovable protecting groups (PPGs) in the field of combination chemotherapy, we designed and synthesized a photoresponsive hybrid prodrug 4 that bearing both doxorubicin (DOX) and combretastatin A4 (CA4). Light triggered drug release investigation found that DOX release was mainly accomplished by 405 nm light while CA4 release was mainly triggered by 365 nm light, i.e. Read More
Cell Syst 2018 Nov 30. Epub 2018 Nov 30.
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA. Electronic address:
Transcriptional and translational feedback loops in fungi and animals drive circadian rhythms in transcript levels that provide output from the clock, but post-transcriptional mechanisms also contribute. To determine the extent and underlying source of this regulation, we applied newly developed analytical tools to a long-duration, deeply sampled, circadian proteomics time course comprising half of the proteome. We found a quarter of expressed proteins are clock regulated, but >40% of these do not arise from clock-regulated transcripts, and our analysis predicts that these protein rhythms arise from oscillations in translational rates. Read More