925,878 results match your criteria Applied Health Economics and Health Policy [Journal]


A Novel Variant of the FZD4 Gene in a Chinese Family Causes Autosomal Dominant Familial Exudative Vitreoretinopathy.

Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.

Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,

Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.

Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More

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December 2018
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Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-β3 and TSP-1 to Elicit Macrophage M2 Polarization.

Cell Physiol Biochem 2018 7;51(5):2290-2308. Epub 2018 Dec 7.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou,

Background/aims: Increasing evidence has demonstrated the novel roles of mesenchymal stem cells (MSCs) in immunotherapy. However, difficulty in acquiring these cells and possible ethical issues limited their application. Recently, we have isolated a unique MSC population from dental follicles with potent stem cell-like properties. Read More

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December 2018

Hypoxia Preconditioning of Human MSCs: a Direct Evidence of HIF-1α and Collagen Type XV Correlation.

Cell Physiol Biochem 2018 7;51(5):2237-2249. Epub 2018 Dec 7.

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara,

Background/aims: Mesenchymal stromal cells (MSCs) hold considerable promise in bone tissue engineering, but their poor survival and potency when in vivo implanted limits their therapeutic potential. For this reason, the study on culture conditions and cellular signals that can influence the potential therapeutic outcomes of MSCs have received considerable attention in recent years. Cell maintenance under hypoxic conditions, in particular for a short period, is beneficial for MSCs, as low O2 tension is similar to that present in the physiologic niche, however the precise mechanism through which hypoxia preconditioning affects these cells remains unclear. Read More

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December 2018

Failure mode in first-principles computational tensile tests of grain boundaries: effects of a bulk-region size, dominant factors, and local-energy and local-stress analysis.

J Phys Condens Matter 2018 Dec 11. Epub 2018 Dec 11.

Tohoku Daigaku Daigakuin Kogaku Kenkyuka Kogakubu, Sendai, Miyagi, JAPAN.

A first-principles computational tensile test (FPCTT) is a powerful tool to investigate intrinsic strength and failure processes of grain boundaries (GBs), according to atomic and electronic behaviors based on density-functional theory, while careful interpretation is required in comparison with experiments, because of ideal conditions used in FPCTTs. We observed serious effects of a bulk-region size in FPCTTs of the {001} Σ5 GB in Al. For a GB supercell with enough thick bulk regions, the energy-strain curve shows spontaneous failure with catastrophic energy release just after the maximum stress point, which we name Type-A failure. Read More

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December 2018

Disclosing odd symmetry, strain driven magnetic response of Co on Pt/PMN-PT (011).

J Phys Condens Matter 2018 Dec 11. Epub 2018 Dec 11.

ALBA Synchrotron Light Source, Cerdanyola del Valles, SPAIN.

An odd-symmetry magnetic response of multiferroic composites comprising ultrathin Co layers on Pt electrode (20 nm) on PMN-PT (011) piezoelectric substrates is observed upon electrical poling of the PMN-PT substrates: The magnetic easy axis of the Co rotates by 90 degrees in-plane between oppositely poled ferroelectric states, mimicking the signature of a surface polarization charge driven effect, which however can be excluded from the presence of the thick Pt interlayer. The origin for this unexpected behavior is as an odd symmetry piezoelectric response of the PMN-PT substrate, as indicated by X-ray diffraction with applied poling, in combination with conventional magnetoelastic coupling. Ferroelectric characterization reveals corresponding features, possibly related to an unswitchable polarization component. Read More

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December 2018

Cu2O porous nanostructured films fabricated by positive bias sputtering deposition.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

Changzhou University, Changzhou, 213164, CHINA.

In this work, the authors fabricated Cu2O porous nanostructured films (PNFs) on glass slide substrates by the newly developed positive bias deposition approach in a balanced magnetron sputtering (MS) system. It was found that the surface morphology, crystal structure and optical property of the as-deposited products were greatly dependent on the applied positive substrate bias. In particular, when the substrate was biased at +50 V and +150 V, both of the as-prepared Cu2O PNFs exhibited a unique triangular pyramids-like structure with obvious edges and corners and little gluing, a preferred orientation of (111) and a blue shift of energy band gap at 2. Read More

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December 2018

Integration of sputter-deposited multiferroic CoFe2O4-BiFeO3 nanocomposites on conductive La0.7Sr0.3MnO3 electrodes.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

Myongji University - Natural Science Campus, Yongin, 449-728, Korea (the Republic of).

The structure, magnetic and ferroelectric properties of sputtered epitaxial CoFe2O4-BiFeO3 (CFO-BFO) nanocomposite thin films grown on La0.7Sr0.3MnO3 (LSMO) layers on (001) oriented SrTiO3 (STO) substrates and on STO-buffered Si are described. Read More

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December 2018

Superconducting transition temperatures in the electronic and magnetic phase diagrams of Sr2VFeAsO3-δ, a superconductor.

J Phys Condens Matter 2018 Dec 11. Epub 2018 Dec 11.

Department of Applied Physics and Physico-Informatics Faculty of Sciences and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Yokohama, JAPAN.

We unveil magnetic phases and superconducting transition temperatures (<i>T</i><sub>c</sub>) in an iron-based superconductor with a thick-blocking layer of a perovskite-related transition metal oxide, Sr<sub>2</sub>VFeAsO<sub>3-δ</sub> (21113V). 21113V exhibits a superconducting phase in 0.031 ≦ <i>δ</i> ≦ 0. Read More

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December 2018

Plan-view transmission electron microscopy specimen preparation for atomic layer materials using a focused ion beam approach.

Ultramicroscopy 2018 Dec 5;197:95-99. Epub 2018 Dec 5.

Department of Materials Science and Engineering, National Taiwan University, Taipei 10617, Taiwan; Center of Atomic Initiative for New Materials, National Taiwan University, Taipei 10617, Taiwan. Electronic address:

Using the focused ion beam (FIB) to prepare plan-view transmission electron microscopy (TEM) specimens is beneficial for obtaining structural information of two-dimensional atomic layer materials, such as graphene and molybdenum disulfide (MoS) nanosheets supported on substrates. The scanning electron microscopy (SEM) image in a dual-beam FIB-SEM can accurately locate an area of interest for specimen preparation. Besides, FIB specimen preparation avoids damages and hydrocarbon contamination that are usually produced in other preparation methods, in which chemical etching and polymer adhesion layers are used. Read More

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December 2018

The refractory epilepsy screening tool for Lennox-Gastaut syndrome (REST-LGS).

Epilepsy Behav 2018 Dec 8;90:148-153. Epub 2018 Dec 8.

Icahn School of Medicine at Mount Sinai Health Systems, 10 Union Square East, Suite 5G, New York, NY 10003, USA. Electronic address:

Background: The complex clinical presentation and progression of Lennox-Gastaut syndrome (LGS) can complicate the accurate diagnosis of this severe, lifelong, childhood-onset epilepsy, often resulting in suboptimal treatment. The Refractory Epilepsy Screening Tool for LGS (REST-LGS) was developed to improve the identification of patients with LGS.

Methods: Using the Modified Delphi Consensus, a group of experts developed and tested the REST-LGS Case Report Form (CRF) comprising 8 criteria (4 major, 4 minor) considered potentially indicative of LGS. Read More

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December 2018

Environmentally benign conversion of waste polyethylene terephthalate to fluorescent carbon dots for "on-off-on" sensing of ferric and pyrophosphate ions.

J Colloid Interface Sci 2018 Dec 4;538:481-488. Epub 2018 Dec 4.

School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. Electronic address:

The increasing production of waste polyethylene terephthalate (PET) is a growing problem worldwide. Environmentally benign conversion of waste PET to valuable materials remains a substantial challenge. In this paper, we developed a green route to reuse waste PET for low-cost synthesis of fluorescent carbon dots (CDs) via air oxidation followed by hydrothermal treatment in aqueous HO solution. Read More

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December 2018

Phytotoxicity of individual and binary mixtures of rare earth elements (Y, La, and Ce) in relation to bioavailability.

Environ Pollut 2018 Dec 4;246:114-121. Epub 2018 Dec 4.

School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China.

Rare earth elements (REEs) are typically present as mixtures in the environment, but a quantitative understanding of mixture toxicity and interactions of REEs is still lacking. Here, we examined the toxicity to wheat (Triticum aestivum L.) of Y, La, and Ce when applied individually and in combination. Read More

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December 2018
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Measuring the water content in freshly-deposited fingermarks.

Forensic Sci Int 2018 Nov 26;294:204-210. Epub 2018 Nov 26.

Institute of Chemistry, The Hebrew University, Jerusalem, Israel. Electronic address:

The literature view regarding the composition of deposited fingermarks has long been that the average water content is in the range of 98-99wt.%. This value has recently been challenged by Kent, claiming that it should be 20wt. Read More

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November 2018
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A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer.

Cancer Epidemiol 2018 Dec 8;58:104-110. Epub 2018 Dec 8.

Department of Bioinformatics & Applied Sciences, Indian Institute of Information Technology, Allahabad, 211015, India. Electronic address:

Pancreatic cancer remains the fourth leading cause of cancer-related death in the world, and will continue to become the number two cause of cancer-related death unless a remarkable breakthrough is achieved. With a slim chance of early diagnosis, surgery can only provide a median survival of 17-23 months. The presence of a dense stroma makes this cancer resilient to chemotherapy, with very few potent inhibitors like nab paclitaxelin available that can work in combination with chemotherapeutic agents. Read More

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December 2018
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QSPR estimation models of normal boiling point and relative liquid density of pure hydrocarbons using MLR and MLP-ANN methods.

J Mol Graph Model 2018 Nov 29;87:109-120. Epub 2018 Nov 29.

Laboratory of Biomaterials and Transport Phenomena (LBMPT), University of Médéa, Médéa, 26000, Algeria.

This work aimed to predict the normal boiling point temperature (Tb) and relative liquid density (d20) of petroleum fractions and pure hydrocarbons, through a multi-layer perceptron artificial neural network (MLP-ANN) based on the molecular descriptors. A set of 223 and 222 diverse data points for Tb and d20 were respectively used to build two quantitative structure property relationships-artificial neural network (QSPR-ANN) models. For each model, the total database was divided respectively into two subsets: 80% for the training set and 20% for the test set. Read More

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November 2018

A multifunctional sensor for selective and sensitive detection of vitamin B12 and tartrazine by Förster resonance energy transfer.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:178-188. Epub 2018 Dec 4.

Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong 637002, China; Institute of Applied Chemistry, China West Normal University, Nanchong 637002, China. Electronic address:

We used thiamine nitrate (TN) as single material to fabricate nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) with a quantum yield of 10.4% through one-pot hydrothermal method, and its properties were characterized by TEM, XPS, FTIR, fluorescence (FL) and UV-vis spectrophotometer, respectively. The fluorescence of N,S-CQDs was effectively quenched in the presence of vitamin B12 (VB12)/tartrazine due to Förster resonance energy transfer (FRET). Read More

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December 2018

In vitro profiling of volatile organic compounds released by Simpson-Golabi-Behmel syndrome adipocytes.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 28;1104:256-261. Epub 2018 Nov 28.

Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Carinagasse 47, A-6800 Feldkirch, Austria; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein; Medical Central Laboratories, A-6800 Feldkirch, Austria.

Breath analysis offers a non-invasive and rapid diagnostic method for detecting various volatile organic compounds that could be indicators for different diseases, particularly metabolic disorders including type 2 diabetes mellitus. The development of type 2 diabetes mellitus is closely linked to metabolic dysfunction of adipose tissue and adipocytes. However, the VOC profile of human adipocytes has not yet been investigated. Read More

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November 2018

Exogenous alpha lipoic acid can stimulate photosystem II activity and the gene expressions of carbon fixation and chlorophyll metabolism enzymes in maize seedlings under drought.

J Plant Physiol 2018 Nov 29;232:65-73. Epub 2018 Nov 29.

Department of Biology, Faculty of Science, Karadeniz Technical University, 61080, Trabzon, Turkey. Electronic address:

Protective compounds such as non-enzymatic antioxidants, osmolytes and signal molecules have been applied to plants exposed to various environmental stresses to increase their stress tolerance. However, there are not enough records about the response of plants to alpha lipoic acid (ALA) application with antioxidant properties. Therefore, this study was designed to evaluate the function of exogenous ALA on the photosynthetic performance of maize seedlings grown in hydroponic conditions under drought stress. Read More

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November 2018

Changes in proteolytic activity and protein carbonylation in shoots of Alyssum montanum ecotypes under multi-metal stress.

J Plant Physiol 2018 Nov 19;232:61-64. Epub 2018 Nov 19.

Unit of Botany and Plant Physiology, Institute of Plant Biology and Biotechnology, University of Agriculture in Krakow, Al. 29 Listopada 54, 31-425, Krakow, Poland.

The aim of present study was to evaluate the proteolytic response of metallicolous (M) and nonmetallicolous (NM) ecotypes of Alyssum montanum under heavy metals (HMs) stress. Therefore, shoot cultures of tested species grown on medium enriched simultaneously with 0.7 mM ZnSO, 3. Read More

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November 2018

A roadmap towards a functional paradigm for learning & memory in plants.

J Plant Physiol 2018 Nov 8;232:209-215. Epub 2018 Nov 8.

Institute of Applied Biosciences, Center for Research & Technology (CERTH), Thessaloniki, Greece.

In plants, the acquisition, processing and storage of empirical information can result in the modification of their behavior according to the nature of the stimulus, and yet this area of research remained relatively understudied until recently. As the body of evidence supporting the inclusion of plants among the higher organisms demonstrating the adaptations to accomplish these tasks keeps increasing, the resistance by traditional botanists and agricultural scientists, who were at first cautious in allowing the application of animal models onto plant physiology and development, subsides. However, the debate retains much of its heat, a good part of it originating from the controversial use of nervous system terms to describe plant processes. Read More

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November 2018

Metabolomic and transcriptional analyses reveal the mechanism of C, N allocation from source leaf to flower in tea plant (Camellia sinensis. L).

J Plant Physiol 2018 Nov 10;232:200-208. Epub 2018 Nov 10.

Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, 31008, China. Electronic address:

Tea flowering in late autumn competes for a large amount of nitrogen and carbohydrates, potentially undermines the storage of these resources in vegetative organs, and negatively influences the subsequent spring tea yield and quality. The mechanism underlying the re-allocation N and carbohydrate from source leaf to flower in tea plant has not been clearly understood. In this study, N allocation, changes in metabolomics, and gene expression in flower buds, flowers, and adjacent leaves were characterized. Read More

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November 2018

Green synthesis of reduced graphene oxide using bagasse and its application in dye removal: A waste-to-resource supply chain.

Chemosphere 2018 Dec 3;219:148-154. Epub 2018 Dec 3.

School of Environmental Science and Engineering, Fujian Normal University, Fuzhou 350007, Fujian Province, China. Electronic address:

Graphene is usually synthesized through deoxygenation of graphene oxide (GO) by hydrazine which functions as a reducing agent, but the production of graphene via this method suffers a high cost and is often regarded to be not environmental-friendly. In this work, we developed a simple and efficient method for the green reduction of GO to reduced graphene oxide (rGO) dispersed on sugarcane bagasse derived from rGO/bagasse material. The rGO/bagasse was characterized by Scanning electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, Thermogravimetric analysis, X-ray photoelectron spectroscopy and X-ray diffraction analysis. Read More

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December 2018

Enhanced removal of coumarin by a novel O/SPC system: Kinetic and mechanism.

Chemosphere 2018 Dec 4;219:100-108. Epub 2018 Dec 4.

School of Civil Engineering, Southeast University, Nanjing, 210096, China; Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education, Southeast University, Nanjing, 210096, China.

A high-efficient, eco-friendly and applicable oxidant of percarbonate (SPC, NaCO·1.5HO) is applied as oxidant in ozonation (O) process. In this work, coumarin (COU) decomposition by O and O/SPC was proposed in terms of diverse parameters, including ozone concentration, SPC dosage and pH, with regard to the pseudo-first-order kinetic model. Read More

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December 2018

Estimating soil nitrate leaching of nitrogen fertilizer from global meta-analysis.

Sci Total Environ 2018 Dec 4;657:96-102. Epub 2018 Dec 4.

Key Lab of Plant-Soil Interaction, Ministry of Education, Center for Resources, Environment and Food Security, College Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China. Electronic address:

Global estimates of soil nitrate leaching of applied nitrogen (N) in agricultural production systems are not imprecise; however, the results of some field experiments have suggested that nitrate leaching responds exponentially rather than linearly to increasing N inputs. In this study, we compiled field data on nitrate leaching for 324 site-year combinations extracted from 86 peer-reviewed articles to test the hypothesis that in response to N fertilizer addition, soil nitrate leaching emission factors (EF) do not remain constant, but rather increase rapidly with increasing rates of N application. The averaged overall results showed that the proportional change in the EF response to increasing N input (ΔEF, %) was 0. Read More

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December 2018
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Effectiveness assessment of risk reduction measures at coastal areas using a decision support system: Findings from Emma storm.

Sci Total Environ 2018 Dec 1;657:124-135. Epub 2018 Dec 1.

CIMA/FCT, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. Electronic address:

Storms impact coastal areas often causing damages and losses at occupied areas. On a scenario of increasing human occupation at coastal zones and under climate change conditions (including sea level rise and increasing frequency of extreme sea levels), the consequences of storms are expected to be amplified if no adaptation or further management actions are implemented. The selection of the best possible coastal management measures, considering both costs and effectiveness, will be mandatory in the future, in order to optimise resources. Read More

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December 2018

Influence of patient positioning on reported clinical outcomes after greater occipital nerve block for treatment of headache: Results from prospective single-centre, non-randomised, proof-of-concept study.

Clin Neurol Neurosurg 2018 Dec 3;176:73-77. Epub 2018 Dec 3.

Science & Innovation Manager, R&D Department, Cumbria Partnership NHS Foundation Trust, Carlisle, CA1 3SX, UK. Electronic address:

Objective: Greater occipital nerve (GON) block is a treatment option applied for a variety of primary headache disorders. Although a patient's body position is known to have an impact on the effect of local anaesthetics, this has not before been investigated for patients undergoing GON block. Therefore, the clinical effectiveness of either a sitting or supine position was assessed. Read More

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December 2018

Age-related differences in task-induced brain activation is not task specific: Multivariate pattern generalization between metacognition, cognition and perception.

Neuroimage 2018 Dec 8. Epub 2018 Dec 8.

Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands.

Adolescence is associated with widespread maturation of brain structures and functional connectivity profiles that shift from local to more distributed and better integrated networks, which are active during a variety of cognitive tasks. Nevertheless, the approach to examine task-induced developmental brain changes is function-specific, leaving the question open whether functional maturation is specific to the particular cognitive demands of the task used, or generalizes across different tasks. In the present study we examine the hypothesis that functional brain maturation is driven by global changes in how the brain handles cognitive demands. Read More

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December 2018
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Explaining consumers' intentions towards purchasing green food in Qingdao, China: The amendment and extension of the theory of planned behavior.

Appetite 2018 Dec 8. Epub 2018 Dec 8.

Department of Organic Food Quality and Food Culture, Faculty of Organic Agricultural Sciences, University of Kassel, Nordbahnhofstrasse 1A, 37213, Witzenhausen, Germany.

This study aims to investigate consumers' green food purchase intentions using a survey conducted in Qingdao, Shandong Province, China. Based on the Theory of Planned Behavior (TPB), it models the influences of Chinese culture and consumer characteristics towards purchasing green food products. According to TPB, the behavioral intention is determined by attitude, subjective norms and perceived behavioral control, whereas subjective norms vary according to differences in cultural systems. Read More

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December 2018

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 Dec;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Read More

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December 2018

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Cancer Cell 2018 Dec;34(6):954-969.e4

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Molecular Medicine and Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 413, Taiwan. Electronic address:

Multiple mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been identified in EGFR-mutant non-small cell lung cancer (NSCLC); however, recurrent resistance to EGFR TKIs due to the heterogeneous mechanisms underlying resistance within a single patient remains a major challenge in the clinic. Here, we report a role of nuclear protein kinase Cδ (PKCδ) as a common axis across multiple known TKI-resistance mechanisms. Specifically, we demonstrate that TKI-inactivated EGFR dimerizes with other membrane receptors implicated in TKI resistance to promote PKCδ nuclear translocation. Read More

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December 2018
23.523 Impact Factor

Immunodivergence in Metastatic Colorectal Cancer.

Cancer Cell 2018 Dec;34(6):876-878

Clinica Universidad de Navarra, Pamplona, Spain; CIBERONC, Madrid, Spain; Center for applied Medical Research (CIMA), Pamplona, Spain; IDISNA, Pamplona, Spain. Electronic address:

Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving adaptive immune responses. Read More

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December 2018

Sol gel synthesis of hybrid chitosan/calcium aluminosilicate nanocomposite membranes and its application as support for CO sensor.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Inorganic Chemistry Department, National Research Centre, El-Buhouth St., Dokki, Giza 12622, Egypt; Packaging Materials Department, National Research Centre, El-Bohouth St., Dokki, Giza 12622, Egypt. Electronic address:

Modification of chitosan with cross-linkers, blends with various kinds of polymers, nanoparticles and new organic-inorganic hybrid composites in order to obtain some improved properties attached more attention nowadays due to their good sensitivity in changing electrical and optical properties. In the current work modified hybrid chitosan/calcium aluminosilicate (CH/CAS) nanocomposite membranes and doped with (3, 5 & 7 mol%) AlO nanoparticles were synthesized via sol-gel process in acidic conditions, which can be efficiently employed to capture CO gas at lower and moderate temperatures. Furthermore, the fabricated CH/CAS nanocomposite membrane loading with (3, 5 & 7 mol%) AlO were investigated using XRD, SEM, FTIR and dielectric measurements. Read More

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December 2018

Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes.

J Control Release 2018 Dec 8. Epub 2018 Dec 8.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5, 8093 Zurich, Switzerland.

In glioblastoma, the benefit from temozolomide chemotherapy is largely limited to a subgroup of patients (30-35%) with tumors exhibiting methylation of the promoter region of the O-methylguanine-DNA methyltransferase (MGMT) gene. In order to allow more patients to benefit from this treatment, we explored magnetic resonance image-guided microbubble-enhanced low-intensity pulsed focused ultrasound (LIFU) to transiently open the blood-brain barrier and deliver a first-in-class liposome-loaded small molecule MGMT inactivator in mice bearing temozolomide-resistant gliomas. We demonstrate that a liposomal O-(4-bromothenyl)guanine (OBTG) derivative can efficiently target MGMT, thereby sensitizing murine and human glioma cells to temozolomide in vitro. Read More

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December 2018

Feature selection and tumor classification for microarray data using relaxed Lasso and generalized multi-class support vector machine.

J Theor Biol 2018 Dec 8. Epub 2018 Dec 8.

College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address:

At present, the study of gene expression data provides a reference for tumor diagnosis at the molecular level. It is a challenging task to select the feature genes related to the classification from the high-dimensional and small-sample gene expression data and successfully separate the different subtypes of tumor or the normal from the patient. In this paper, we present a new method for tumor classification-relaxed Lasso (least absolute shrinkage and selection operator) and generalized multi-class support vector machine (rL-GenSVM). Read More

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December 2018

Mathematical analysis of a tumour-immune interaction model: A moving boundary problem.

Math Biosci 2018 Dec 8. Epub 2018 Dec 8.

Department of Mathematical Sciences, Stellenbosch University, Private Bag X1 Matieland, 7602, South Africa. Electronic address:

A spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. Analysis of the model is carried out for both temporal and spatio-temporal cases. Stability analysis and numerical simulations of the temporal model replicate experimental observations of immune-induced tumour dormancy. Read More

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December 2018

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin.

J Pharm Sci 2018 Dec 8. Epub 2018 Dec 8.

Faculty of Pharmaceutical Sciences, Sojo University; DDS Research Institute, Ikeda 4-22-Nishi-ku, Kumamoto 860-0082, Japan. Electronic address:

Previously, we reported on the high affinity binding of aripiprazole (ARP), an antipsychotic drug, to human albumin and the role of the chlorine atom of ARP on this binding. In this study, we investigated the binding mode of ARP to human albumin in detail using ARP derivatives and several animal-derived albumins. ARP bound strongly to human and dog albumin. Read More

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December 2018

Outcomes of Peer Review for Radiotherapy Treatment Plans With Palliative Intent.

J Oncol Pract 2018 Dec;14(12):e794-e800

Southlake Regional Health Centre, Newmarket; and University of Toronto, Toronto, Ontario, Canada.

Purpose:: Peer review of a proposed treatment plan is increasingly recognized as an important quality activity in radiation medicine. Although peer review has been emphasized in the curative setting, applying peer review for treatment plans that have palliative intent is receiving increased attention. This study reports peer review outcomes for a regional cancer center that applied routine interprofessional peer review as a standard practice for palliative radiotherapy. Read More

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December 2018

Quality Improvement Training in a Variety of Cancer Care Delivery Settings: Experiences From a Comprehensive Cancer Center, an Academic Medical Center, and Community Practices.

J Oncol Pract 2018 Dec;14(12):e815-e822

Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Partners HealthCare; and Massachusetts General Hospital, Boston, MA.

Purpose:: Training clinical and supportive staff in quality improvement (QI) theory and use of QI tools has the potential to improve oncology care delivery. We report our combined experience of providing training to oncologists in a variety of local settings and assess the effect of the training on individual participants and for institutions.

Methods:: Multidisciplinary oncology teams at a comprehensive cancer center, an academic medical center, and community practices were led through experiential QI training that spanned several months. Read More

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December 2018

Synthesis of Negative-Charged Metal-Containing Cyclomatrix Polyphosphazene Microspheres Based on Polyoxometalates and Application in Charge-Selective Dye Adsorption.

Macromol Rapid Commun 2018 Dec 7:e1800730. Epub 2018 Dec 7.

Department of Applied Chemistry, School of Science MOE Key Lab for Materials Physics and Chemistry Extraordinary Condition, Northwestern Polytechnical University, Xi'an 710129, Shaanxi, China.

A negative-charged, metal-containing cyclomatrix polyphosphazene microsphere (MCPM) is synthesized using the strategy of precipitation polymerization of di-functionalized polyoxometalates (POMs) and hexachlorocyclotriphosphazene. The chemical structure of these MCPMs is well characterized by C MAS NMR and P MAS NMR, as well as FT-IR, electron microscopy, and X-ray photoelectron spectroscopy. The covalent grafting of the rigid POMs clusters into the framework of these microspheres prevents the collapsing of the pores, making these MCPMs porous materials. Read More

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December 2018

Improved resin-to-dentin bond strength and durability via non-thermal atmospheric pressure plasma drying of etched dentin.

Eur J Oral Sci 2018 Dec 9. Epub 2018 Dec 9.

Department of Health Policy and Management, College of Health Science, Seoul, Korea.

This study aimed to evaluate the improvement in strength and durability of the bond between dentin and composite resins following plasma drying of the etched dentin surface using non-thermal atmospheric pressure plasma. Plasma drying was applied to the etched dentin before applying adhesive. Conventional wet-bonding and helium (He) gas-dried bonding schemes were used as control groups. Read More

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December 2018

Protein-Bound Freestanding 2D Metal Film for Stealth Information Transmission.

Adv Mater 2018 Dec 9:e1803377. Epub 2018 Dec 9.

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.

The welding and sintering of nanomaterials is usually achieved at high temperatures and high pressures. Here, it is found that merging of metal nanoparticles occurs under ambient conditions in an aqueous solution via protein bonding. It is discovered that the silver nanoparticles from the in situ reduction of silver ammonium ions by glucose undergo confined nucleation and growth and are bound by ultrathin amyloid-like β-sheet stacking of lysozyme. Read More

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December 2018

Trust, Money, and Power: Life Cycle Dynamics in Alliances Between Management Partners and Accountable Care Organizations.

Milbank Q 2018 Dec;96(4):755-781

Gillings School of Public Health, University of North Carolina at Chapel Hill.

Policy Points Accountable care organizations (ACOs) form alliances with management partners to access financial, technical, and managerial support. Alliances between ACOs and management partners are subject to destabilizing tension around decision-making authority, distribution of shared savings, and conflicting goals and values. Management partners may serve either as trainers, ultimately breaking off from the ACO, or as central drivers of the ACO. Read More

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December 2018

Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture.

Biotechnol J 2018 Nov 22:e1800376. Epub 2018 Nov 22.

Department of Chemical Engineering, Faculty of Engineering, Imperial College London, London, UK.

To stop the spread of future epidemics and meet infant vaccination demands in low- and middle-income countries, flexible, rapid and low-cost vaccine development and manufacturing technologies are required. Vaccine development platform technologies that can produce a wide range of vaccines are emerging, including: a) humanized, high-yield yeast recombinant protein vaccines; b) insect cell-baculovirus ADDomer vaccines; c) Generalized Modules for Membrane Antigens (GMMA) vaccines; d) RNA vaccines. Herein, existing and future platforms are assessed in terms of addressing challenges of scale, cost, and responsiveness. Read More

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November 2018

Linear mixed models for association analysis of quantitative traits with next-generation sequencing data.

Genet Epidemiol 2018 Dec 9. Epub 2018 Dec 9.

Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland.

We develop linear mixed models (LMMs) and functional linear mixed models (FLMMs) for gene-based tests of association between a quantitative trait and genetic variants on pedigrees. The effects of a major gene are modeled as a fixed effect, the contributions of polygenes are modeled as a random effect, and the correlations of pedigree members are modeled via inbreeding/kinship coefficients. -statistics and χ likelihood ratio test (LRT) statistics based on the LMMs and FLMMs are constructed to test for association. Read More

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December 2018

Nucleated red blood cells as a novel indicator of CD34 cell content in umbilical cord blood.

Transfusion 2018 Dec 7. Epub 2018 Dec 7.

Cell Therapy Laboratory, San Diego Blood Bank, San Diego, California.

Background: Umbilical cord blood (UCB) has become an important source of transplantable CD34 hematopoietic progenitor cells. Cord blood banks (CBBs) can increase their efficiency by minimizing the processing of UCB units with low CD34 content, which have a lower likelihood of transplant utilization. We sought to identify a readily available preprocessing metric that would correlate with CD34 cell counts, without the cost of additional analysis. Read More

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December 2018

Treating tumors at low drug doses using an aptamer-peptide synergistic drug conjugate.

Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.

Harvard University John A Paulson School of Engineering and Applied Sciences, 29 Oxford Street, 02138, Cambridge, UNITED STATES.

Combination chemotherapy must strike a difficult balance between safety and efficacy. Current regimens suffer from poor therapeutic impact because drugs are given at their maximum tolerated dose (MTD), which compounds the toxicity risk and exposes tumors to non-optimal drug ratios. We developed a modular framework that selectively delivers drug combinations at synergistic ratios via tumor-targeting aptamers for effective low-dose treatment. Read More

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December 2018

A NEW COMPREHENSIVE PROCEDURE FOR CUSTOM-MADE TOTAL ANKLE REPLACEMENTS: MEDICAL IMAGING, JOINT MODELING, PROSTHESIS DESIGN, AND 3D PRINTING.

J Orthop Res 2018 Dec 11. Epub 2018 Dec 11.

Movement Analysis Laboratory, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Many failures in total joint replacement are associated to prosthesis-to-bone mismatch. With recent additive-manufacturing, i.e. Read More

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December 2018

Virus genotyping by massive parallel amplicon sequencing: adenovirus and enterovirus in the Norwegian MIDIA study.

J Med Virol 2018 Dec 10. Epub 2018 Dec 10.

Division of Mental and Physical Health, Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: Direct genotyping of adenovirus or enterovirus from clinical material using polymerase chain reaction (PCR) followed by Sanger sequencing is often difficult due to the presence of multiple virus types in a sample, or due to varying efficacy of PCR amplifying the capsid gene on the background of foreign nucleic acids. Here we present a simple protocol for virus genotyping using massive parallel amplicon sequencing.

Methods: The protocol utilized a set of 16 tailed degenerate primers flanking the seventh hypervariable region of the adenovirus hexon gene and 9 tailed degenerate primers targeted to the proximal portion of the enterovirus VP1 gene. Read More

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December 2018

YHp as a highly stable, hyper-copy, hyper-expression plasmid constructed using a full 2 μm circle sequence in cir0 strains of Saccharomyces cerevisiae.

Yeast 2018 Dec 7. Epub 2018 Dec 7.

Department of Applied Chemistry, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Ube, 755-8611, Japan.

In the yeast Saccharomyces cerevisiae, the plasmid YEp, containing a partial sequence from a natural 2 μm plasmid, has been frequently used to induce high levels of gene expression. In this study, we used Japanese sake yeast natural cir0 strain as a host for constructing an entire 2 μm plasmid with an expression construct using the three-fragment gap-repair method without Escherichia coli manipulation. The 2 μm plasmid contains two long inverted repeats, which is problematic for PCR amplification. Read More

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December 2018

Technical Note: A method for quality assurance of landmark sets for use in evaluation of deformable image registration accuracy of lung parenchyma.

Med Phys 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, 63110, USA.

Purpose: To develop a quality control method to improve the accuracy of corresponding landmark sets used for deformable image registration evaluation in the lung parenchyma.

Methods: An iterative workflow was developed as a method for quality assurance of landmark sets. Starting with the initial landmark set for a given image pair, a landmark-based deformation was applied to one of the images. Read More

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December 2018
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