8 results match your criteria Applied Clay Science[Journal]

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PEGylated green halloysite/spinel ferrite nanocomposites for pH sensitive delivery of dexamethasone: A potential pulmonary drug delivery treatment option for COVID-19.

Appl Clay Sci 2022 Jan 9;216:106333. Epub 2021 Nov 9.

Center for Refining and Advanced Chemicals, Research Institute, King Fahd University of Petroleum and Minerals, 31261 Dhahran, Saudi Arabia.

Dexamethasone (Dex) is used in drug regimen for treatment of Coronavirus disease (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fusion and entry into the cell occurs at pH 5.5. Read More

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January 2022

Modeling of the adsorption of a protein-fragment on kaolinite with potential antiviral activity.

Appl Clay Sci 2020 Dec 14;199:105865. Epub 2020 Oct 14.

Instituto Andaluz de Ciencias de la Tierra, CSIC-UGR, Av. de las Palmeras 4, 18100 Armilla, Granada, Spain.

This work aimed at studying the potentiality of interactions between kaolinite surfaces and a protein-fragment (350-370 amino acid units) extracted from the glycoprotein E1 in the transmembrane domain (TMD) of hepatitis C virus capsid. A computational work was performed for locating the potential electrostatic interaction sites between kaolinite aluminol and siloxane surfaces and the residues of this protein-fragment ligand, monitoring the possible conformational changes. This hydrated neutralized kaolinite/protein-fragment system was simulated by means of molecular modeling based on atomistic force fields based on empirical interatomic potentials and molecular dynamic (MD) simulations. Read More

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December 2020

Development of broad-acting clays for the tight adsorption of benzo[a]pyrene and aldicarb.

Appl Clay Sci 2019 Feb 20;168:196-202. Epub 2018 Nov 20.

Veterinary Integrative Biosciences Department, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.

People and animals can be unintentionally exposed to complex mixtures of hazardous chemicals that can threaten the safety of food and water supplies following natural and man-made disasters and emergencies. Our research has focused on the development of broad-acting adsorbents that will tightly bind environmental contaminants in the gastrointestinal tract and decrease their bioavailability to humans and animals during these events. In this study, benzo[a]pyrene (BaP) and aldicarb were used as representative chemicals due to their high toxicity and extensive distribution in the environment. Read More

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February 2019

Interfacial Structure and Interaction of Kaolinite Intercalated with N-methylformamide Insight from Molecular Dynamics Modeling.

Appl Clay Sci 2018 Jun 4;158:204-210. Epub 2018 Apr 4.

Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824, United States.

The evolution of basal spacing and interfacial structure of kaolinite-N-methylformamide (NMF) complexes during the intercalation process were difficult to obtain using experimental methods. In present study, a series of kaolinite-NMF complex models with various numbers of NMF molecules in the interlayer space were constructed to mimic the progressive stage of the intercalation process of kaolinite intercalated by NMF. The MD simulations were performed on these models to explore the evolution of basal spacing and interfacial structure of kaolinite-NMF complexes during the intercalation process. Read More

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Mechanism Responsible for Intercalation of Dimethyl Sulfoxide in Kaolinite: Molecular Dynamics Simulations.

Appl Clay Sci 2018 Jan 5;151:46-53. Epub 2017 Nov 5.

Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824, United States.

Intercalation is the promising strategy to expand the interlayer region of kaolinite for their further applications. Herein, the adaptive biasing force (ABF) accelerated molecular dynamics simulations were performed to calculate the free energies involved in the kaolinite intercalation by dimethyl sulfoxide (DMSO). Additionally, the classical all atom molecular dynamics simulations were carried out to calculate the interfacial interactions between kaolinite interlayer surfaces and DMSO with the aim at exploring the underlying force that drives the DMSO to enter the interlayer space. Read More

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January 2018

Exfoliation and intercalation of montmorillonite by small peptides.

Appl Clay Sci 2015 Apr;107:173-181

Department of Earth and Atmospheric Sciences, The City College of New York, 160 Convent Ave, New York, NY, 10031.

Understanding structural changes in clay minerals induced by complexation with organic matter is relevant to soil science and agricultural applications. In this study, the effect of peptide storage in montmorillonite and the thermal stability of peptide-clay complexes was examined through characterization by X-ray diffraction (XRD), electron microscopy, UV absorption, and thermogravimetric analysis (TGA). XRD analysis of small peptide-montmorillonite clay complexes produced profiles consisting of reflections associated with the smectite 001 reflection and related peaks similar to that produced by a mixed layer clay mineral structure. Read More

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Characterization and Safety of Uniform Particle Size NovaSil Clay as a Potential Aflatoxin Enterosorbent.

Appl Clay Sci 2011 Dec;54(3-4):248-257

Interdisciplinary Faculty of Toxicology, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University 77843-4458 TAMU, College Station, TX, USA.

NovaSil (NS) clay, a common anti-caking agent in animal feeds, has been shown to adsorb aflatoxins and diminish their bioavailability in multiple animal models. The safety of long-term dietary exposure to NS has also been demonstrated in a 6-month sub-chronic study in rats and in a 3-month intervention in humans highly exposed to aflatoxins. Uniform particle size NovaSil (UPSN) is a refined material derived from parent NS; it contains lower levels of dioxins/furans, and has been selected for a more consistent uniform particle size. Read More

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December 2011

Methylene-Functionalize Saponite: A New Type of Organoclay with CH(2) Groups Substituting for Bridging Oxygen Centers in the Tetrahedral Sheet.

Appl Clay Sci 2010 Mar;48(1-2):60-66

Department of Chemistry, Michigan State University, MI 48824 USA.

The synthesis of saponite in the presence of bis(triethoxysilyl)methane (BTESM) as an organosilicon reagent results in the replacement of up to 33.3 % of the oxygen atoms in the tetrahedral sheet by bridging methylene groups. The methylene-functionalized saponites represent a new form of covalently-bonded organoclay that truly is isomorphic with purely inorganic saponite made under equivalent reaction conditions from sodium silicate as the silicon source. Read More

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