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Neurobiol Aging 2021 May 14;105:217-228. Epub 2021 May 14.

MRC Cognition & Brain Sciences Unit, University of Cambridge, Cambridge, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK.

It is important to maintain cognitive function in old age, yet the neural substrates that support successful cognitive ageing remain unclear. One factor that might be crucial, but has been overlooked due to limitations of previous data and methods, is the ability of brain networks to flexibly reorganize and coordinate over a millisecond time-scale. Magnetoencephalography (MEG) provides such temporal resolution, and can be combined with Hidden Markov Models (HMMs) to characterise transient neural states. Read More

J Colloid Interface Sci 2021 May 26;601:899-914. Epub 2021 May 26.

Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties. Read More

Biosens Bioelectron 2021 Jun 2;190:113394. Epub 2021 Jun 2.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. Electronic address:

To achieve rapid and sensitive detection of aflatoxin B (AFB), we developed a polydimethylsiloxane gravity-driven cyclic microfluidic chip using the two-signal mode strategy. The structural design of the chip, together with the two-wavelength quantum dot ratio fluorescence, effectively eliminates the influence of environmental factors, improves the signal stability, and ensures that the final detection result positively correlates with the target concentration. Moreover, the theoretical analysis performed for the established physical model of the three-dimensional reaction interface inside the chip confirmed the improved reaction rate of immune adsorption in the microfluidic strategy. Read More

Food Chem 2021 Jun 3;363:130278. Epub 2021 Jun 3.

Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. Electronic address:

Tea cultivars possessing purple shoots have attracted global interest. In order to gain a better understanding of the major chemical constituents responsible for the purple colouration, we applied widely targeted metabolomics to investigate the pigmented flavonoids of freeze-dried purple-coloured tea leaves (PTLs) in comparison with green-coloured tea leaves (GTLs). Thirty-three anthocyanins were identified, and delphinidin 3-O-galactoside and cyanidin 3-O-galactoside were found to be the most abundant in PTLs. Read More

Comput Biol Med 2021 Jun 1;134:104537. Epub 2021 Jun 1.

School of Electrical Engineering and Computing, The University of Newcastle, NSW 2308, Australia.

Background: Alzheimer's disease (AD) is one of the deadliest diseases in developed countries. Treatments following early AD detection can significantly delay institutionalisation and extend patients' independence. There has been a growing focus on early AD detection using artificial intelligence. Read More

Arch Oral Biol 2021 May 25;129:105166. Epub 2021 May 25.

Department of Stomatology, Jingmen No.1 People's Hospital, China. Electronic address:

Objective: Human periodontal ligament stem cells (hPDLSCs) play an important role in regenerative engineering technology for periodontal therapy. The mechanism of microRNA (miR)-383-5p in osteogenic differentiation needs further exploration. This study aimed at investigating the potential role of miR-383-5p in the osteogenic differentiation of hPDLSCs. Read More

Growth Horm IGF Res 2021 Jun 6;59:101407. Epub 2021 Jun 6.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGFI) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175. Read More

J Infect Public Health 2021 Apr 24;14(7):832-838. Epub 2021 Apr 24.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients. Read More

J Infect Public Health 2021 Apr 20;14(7):817-831. Epub 2021 Apr 20.

University School of Basic & Applied Sciences (USBAS), Head, Non-Linear Dynamics-Research-Lab, GGS Indraprastha University, New Delhi, India. Electronic address:

Coronaviruses did not invite attention at a global level and responsiveness until the series of 2003-SARS contagion followed by year-2012 MERS plus, most recently, 2019-nCoV eruptions. SARS-CoV &MERS-CoV are painstaking, extremely pathogenic. Also, very evidently, both have been communicated from bats to palm-civets & dromedary camels and further transferred ultimately to humans. Read More

Eur J Med Chem 2021 May 30;222:113584. Epub 2021 May 30.

Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2, Canada. Electronic address:

Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M) to cleave viral proteins. Consequently, M is a target for antiviral agents. We and others previously demonstrated that GC376, a bisulfite prodrug with efficacy as an anti-coronaviral agent in animals, is an effective inhibitor of M in SARS-CoV-2. Read More

J Subst Abuse Treat 2021 Apr 14;130:108409. Epub 2021 Apr 14.

Nicotine Dependence Services, Centre for Addiction and Mental Health, 175 College St, Toronto, ON M5T 1P7, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 60 White Squirrel Way, Toronto, ON M6J 1H4, Canada; Department of Family and Community Medicine, University of Toronto, 500 University Ave, Toronto, ON M5G 1V7, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College, Toronto, ON M5T 3M7, Canada; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada. Electronic address:

Background: The effectiveness of care for substance-related problems varies across providers. Best-known treatments are rarely universally applied, and various process differences can affect participant outcomes. Measuring and understanding this variability can suggest changes that will improve system performance. Read More

J Subst Abuse Treat 2021 Jun 3;130:108521. Epub 2021 Jun 3.

Humankind Charity, Inspiration House, Unit 22, Bowburn North Industrial Estate, Durham DH6 5PF, United Kingdom.

Background: Methadone use for the management of opioid dependency during pregnancy is commonplace. Methadone levels are altered during pregnancy due to changes in maternal physiology. Despite this, a paucity of data exist regarding the most appropriate optimal dosing regimens during pregnancy. Read More

Sci Total Environ 2021 Jun 5;791:148249. Epub 2021 Jun 5.

CRETUS, Department of Chemical Engineering, Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain.

The sustainable and continued production of enough food to feed the entire world's population is one of the main concerns in the food industry. Spain, and in particular Galicia, which is an eminently fishing region characterised by the consumption of large quantities of fish, both fresh and processed, must face the challenge of shifting its seafood productive fabric towards a circular economy. To achieve this objective, the first task is to demonstrate that circular economy principles allow to reduce the environmental impacts associated with seafood production. Read More

Sci Total Environ 2021 May 26;791:148046. Epub 2021 May 26.

College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China; Hubei Provincial Engineering Laboratory for New-Type Fertilizer, Wuhan 430070, China; Research Center of Trace Elements, Wuhan 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, Wuhan 430070, China. Electronic address:

Huanglongbing (HLB) caused by 'Ca. Liberibacter. Asiaticus (Clas)' is one of the destructive diseases for citrus, threatening the development of citrus industry. Read More

Sci Total Environ 2021 Jun 3;791:148127. Epub 2021 Jun 3.

Institute of Coastal Research, Helmholtz-Zentrum Geesthacht Center for Materials and Coastal Research, Max-Planck Str.1, 21502 Geethacht, Germany. Electronic address:

In order to trace the sources of sediment materials and trace metals in the Weser River system (Germany), and the riverine input to the North Sea, Sr, Nd and Pb isotopes, together with multi-elemental compositions, were measured for sediments collected over the entire Weser River Basin, from headwaters to the estuary. Mass fractions of metals, including Ag, Cd, and Pb, and of one metalloid, Sb, higher than their crustal abundance, were observed within the entire Weser Basin. Isotope-amount ratio n(Sr)/n(Sr) and ε ranged from 0. Read More

Prev Vet Med 2021 Jun 5;193:105399. Epub 2021 Jun 5.

New Ruipeng Pet Healthcare Group Co. LTD., Beijing, 100010, China.

Cardiomegaly is the main imaging finding for canine heart diseases. There are many advances in the field of medical diagnosing based on imaging with deep learning for human being. However there are also increasing realization of the potential of using deep learning in veterinary medicine. Read More

J Psychiatr Res 2021 May 23;140:221-227. Epub 2021 May 23.

Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy.

Objectives: This study examined the moderation of an oxytocin receptor (OXTR) gene in the link between childhood adversity and depressive symptoms among incarcerated males.

Methods: Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (M = 32.4 years, SD = 9. Read More

Chemosphere 2021 Jun 3;282:131012. Epub 2021 Jun 3.

Department of Exploration Geology, Faculty of Geosciences and Geoengineering, Hanoi University of Mining and Geology, 18 Vien st., Duc Thang ward, Bac Tu Liem dist., Hanoi, Viet Nam.

The efforts of this study aimed to evaluate the feasibility of the nanotubular halloysites in weathered pegmatites (NaHWP) for removing heavy metals (i.e., Cd, Pb) from water. Read More

Chemosphere 2021 Jun 4;282:131104. Epub 2021 Jun 4.

School of Environmental Studies. Jadavpur University. Kolkata, 700032, India. Electronic address:

River biofilm communities are the first ones to be exposed to all toxic discharges received via run off from agricultural fields. Hence, changes in river biofilm community structure and growth pattern are considered as indicator of overall health of lotic ecosystem. Toxicants have effect on biofilm biomass, photosynthetic efficiency and chlorophyll a concentrations. Read More

Chemosphere 2021 May 28;282:131025. Epub 2021 May 28.

University of Surrey, Department of Chemical and Process Engineering, Surrey, England, GU2 7XH, UK. Electronic address:

Per- and poly-fluoroalkyl substances (PFAS) are xenobiotics, present at variable concentrations in soils and groundwater worldwide. Some of the current remediation techniques being researched or applied for PFAS-impacted soils involve solidification-stabilisation, soil washing, excavation and disposal to landfill, on site or in situ smouldering, thermal desorption, ball milling and incineration. Given the large volumes of soil requiring treatment, there is a need for a more environmentally friendly technique to remove and treat PFASs from soils. Read More

Chemosphere 2021 Jun 4;282:131088. Epub 2021 Jun 4.

Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address:

In the present study, the activated carbon of lemon (ACL) was generated from Citrus limon wood waste and composited with FeO nanoparticles. The ACL/FeO magnetic composite was effectively used to eliminate Cd from an aqueous solution. The active surface area values for ACL and ACL/FeO magnetic composite were 25. Read More

Chemosphere 2021 May 29;282:131014. Epub 2021 May 29.

University of Bordeaux, UMR CNRS 5805 EPOC, 33615 Pessac, France.

We report here on the development and application of a submersible, compact, low power consumption, integrated multichannel trace metal sensing probe (TracMetal). This probe is unique in that it allows high-resolution, simultaneous in-situ measurements of the potentially bioavailable (so-called dynamic) fraction of Hg(II), As(III), Cd(II), Pb(II), Cu(II), Zn(II). The TracMetal incorporates nanostructured Au-plated and Hg-plated gel-integrated microelectrode arrays. Read More

Chemosphere 2021 May 28;282:131017. Epub 2021 May 28.

Ghent University, Faculty of Bioscience Engineering, Laboratory of Analytical Chemistry and Applied Ecochemistry (Ecochem), Coupure Links 653, B Block, 6th Floor, 9000, Ghent, Belgium. Electronic address:

Demand for phosphorus (P) resources other than non-renewable P rock has driven the development of several P recovery technologies from municipal wastewater treatment and directed recovery of P into valuable fertilizers (struvite, ash, iron phosphate, etc.). Although the bioavailability of novel secondary P fertilizers has been examined in previous studies, insufficient attention has been paid to defining optimal plant growth duration and monitoring conditions to assess the dynamic changes in P. Read More

J Colloid Interface Sci 2021 Jun 3;602:73-94. Epub 2021 Jun 3.

Department of Environmental Research, Institute for Color Science and Technology, Tehran, Iran. Electronic address:

Herein, MIL-101(Fe), CoFeO, novel binary (MIL-101(Fe)/CoFeO, MIL-101(Fe)/GO and CoFeO/GO), and ternary (MIL-101(Fe)/CoFeO/(3%)GO and MIL-101(Fe)/CoFeO/(7%)GO) magnetic composites based upon the MIL-101(Fe) were synthesized. The XRD, FESEM, TEM, EDX, BET-BJH, FTIR, VSM, DRS, PL, EIS and other electrochemical analyses were applied to characterize samples. The MIL/CoFeO/(3%)GO demonstrated the best performance compared to other samples for visible light photocatalytic and photo-Fenton-like degradation of Direct Red 23 (DtR-23), Reactive Red 198 (ReR-198) dyes as well as Tetracycline Hydrochloride (TC-H) antibiotic. Read More

J Colloid Interface Sci 2021 May 31;602:55-63. Epub 2021 May 31.

School of Materials Science and Engineering, Jiangsu Key Laboratory of Advanced Metallic Materials, Southeast University, Nanjing 211189, China. Electronic address:

The electrochemical anodic behavior of transition metal compounds plays an undeniably non-negligible role across many electrooxidation reactions. In this work, a chronopotentiometric technique was employed to activate the multicomponent non-noble metal oxyfluorides in-situ for oxygen evolution reaction (OER). It is interesting to unravel that the increasing applied current density helps to reconstruct the catalyst into nanoporous core-shell structure and introduce metal oxyhydroxide on the surface, which guarantees more channels for efficient ion/mass transportation and thus contributes to exposing more active sites for catalytic reaction. Read More

Neuroimage Clin 2021 Jun 4;31:102712. Epub 2021 Jun 4.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network (CNN) approach based on structural MRI scans that underwent either minimal pre-processing or more extensive pre-processing into modulated gray matter (GM) maps. Classifiers were optimized and evaluated using cross-validation in the Alzheimer's Disease Neuroimaging Initiative (ADNI; 334 AD, 520 CN). Read More

Appl Radiat Isot 2021 Jun 9;175:109801. Epub 2021 Jun 9.

Faculty of Mathematics, Physics and Informatics, Comenius University, 84248, Bratislava, Slovakia.

Uranium and thorium as natural radioactive elements are present everywhere in the environment. Their trace levels are also present in various materials, such as copper, used as a shielding material in gamma-ray spectrometry, usually located very close to the detector. Ultra-low levels of uranium and thorium in electrolytic copper were determined in this study using radiochemical neutron activation analysis (RNAA) via their induced nuclides U-239/Np-239 and Pa-233, respectively. Read More

Mar Pollut Bull 2021 Jun 9;169:112547. Epub 2021 Jun 9.

Programa de Pós-Graduação em Geociências (Geoquímica), Instituto de Química, Universidade Federal Fluminense, Niterói, RJ 24020-150, Brazil.

The Quality Ratio (QR) index was applied in Sepetiba Bay to integrate geochemical and microbiological parameters of the in situ microbial community in order to classify the ecological risk of sediments. Total concentrations (C) of Hg, Cd, As, Pb, Cr, Cu and Zn (indicators of the mixture of contaminants) were determined at 26 stations and at a background area (C) to calculate the contamination factor (CF = C/C) and the degree of contamination (ΣCF). Enzymatic biomarkers of energy production into cell (dehydrogenase - DHA) and hydrolase of organic matter outside the cell (esterases - EST) were determined. Read More

J Pharm Biomed Anal 2021 Jun 3;203:114186. Epub 2021 Jun 3.

Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, PR China. Electronic address:

Chang-Kang-Fang formula (CKF), a multi-herbs traditional Chinese medicine (TCM) prescription for treating irritable bowel syndrome (IBS), has been clinically applied in the traditional form of mixed-herb decoction (MHD), or in the modern form of combined single-herb decoction (cSHD, so called dispensing granule decoction) in the near decades, but the chemical consistency between the MHD and cSHD is still unknown. Herein, a new strategy by integrating multiple-chromatographic approaches to characterize both polysaccharides and small molecules was developed to compare the chemical consistency between MHD and cSHD. Sixteen small molecules were simultaneously qualified and quantified by UPLC-QTOF-MS/MS, the molecular weight distribution of polysaccharides was characterized by HPGPC-ELSD, while the monosaccharide composition and total saccharides content were determined by HPLC-PDA and UV-VIS, respectively. Read More

J Clin Anesth 2021 Jun 9;74:110377. Epub 2021 Jun 9.

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address:

Study Objectives: Post-operative pain is a significant concern following modified radical mastectomy in breast cancer patients. The serratus anterior plane block has recently been described as an effective technique for post-operative analgesia of modified radical mastectomy. The purpose of this study was to evaluate the analgesic efficacy and safety of a new serratus anterior plane (SAP) block for post-operative pain of mastectomy. Read More