1,070,174 results match your criteria Applied Catalysis A-general[Journal]


Systematic characterization of alkaloids in Eomecon chionantha Hance using ultra-high-performance liquid chromatography-tandem quadruple-exactive orbitrap mass spectrometry with a four-step screening strategy.

Rapid Commun Mass Spectrom 2020 Jul 7:e8880. Epub 2020 Jul 7.

Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, 418000, China.

Rationale: Eomecon chionantha Hance (ECH), a traditional folk herb, is commonly used to treat traumatic injuries based on its analgesic and anti-inflammatory properties. Previous studies have reported that alkaloids are the major bioactive components in ECH. Therefore, identification of alkaloids from ECH contributes to the discovery of its potential active ingredients and quality control in clinic treatments. Read More

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http://dx.doi.org/10.1002/rcm.8880DOI Listing

Fatigue Increases in Resting Muscle Oxygen Consumption after a Women's Soccer Match.

Int J Sports Med 2020 Jul 7. Epub 2020 Jul 7.

Faculty of Sport Science, University of Extremadura, Cáceres, Spain.

Currently, near infrared spectroscopy has a clear potential to explain the mechanisms of fatigue by assessing muscle oxygenation. The objective of the study was to observe the changes in muscle oxygen consumption after an official women's soccer match. The sample was 14 players who competing in the second division of Spain of women's soccer. Read More

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http://dx.doi.org/10.1055/a-1177-0849DOI Listing

Incidence of Staphylococcus aureus Infections after Elective Surgeries in U.S. Hospitals.

Clin Infect Dis 2020 Jul 8. Epub 2020 Jul 8.

Departments of Medicine and Surgery; Washington University School of Medicine; St. Louis, MO, USA.

Background: Although S. aureus is a leading cause of postsurgical infections, national estimates of these infections after elective surgeries based on microbiology data are limited. This study assessed cumulative 180-day postsurgical S. Read More

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http://dx.doi.org/10.1093/cid/ciaa913DOI Listing

Outcome of Selective Renal Artery Embolization in Managing Severe Bleeding after Percutaneous Nephrolithotomy.

Urol Int 2020 Jul 7:1-6. Epub 2020 Jul 7.

Urology and Lithotripsy Center, Peking University People's Hospital, Peking, China.

Objectives: The aim of this study was to evaluate the characteristics of the renal arterial segment bleeding and assess the outcome of selective renal artery embolization (SRAE).

Methods: Data on 35 patients in whom SRAE was performed after percutaneous nephrolithotomy (PCNL) from January 2005 to December 2015 in our institute were retrospectively analyzed. All patients had severe bleeding but failed to respond to conservative therapy. Read More

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http://dx.doi.org/10.1159/000508797DOI Listing

Investigating the origins of ultra-short relaxation times of silver filaments in forming-free SiO2-based conductive bridge memristors.

Nanotechnology 2020 Jul 7. Epub 2020 Jul 7.

Institute of Microelectronics, National Centre for Scientific Research 'Demokritos', Athens, GREECE.

The threshold switching effect is considered of outmost importance for a variety of applications ranging from the reliable operation of crossbar architectures to emulating neuromorphic properties with artificial neural networks. This property is strongly believed to be associated with the rich inherit dynamics of a metallic conductive filament (CF) formation and its respective relaxation processes. Understanding the origin of these dynamics is very important in order to control the degree of volatility and design novel electronic devices. Read More

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http://dx.doi.org/10.1088/1361-6528/aba3a1DOI Listing

Micro-UHPLC-MS/MS method for analysis of oxylipins in plasma and platelets.

J Pharm Biomed Anal 2020 Jun 20;189:113426. Epub 2020 Jun 20.

University of Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, Auf der Morgenstelle 8, 72076, Tübingen, Germany. Electronic address:

Oxylipins play an important role in cell signaling and they act as auto- and paracrine factors. There are numerous reports on the analysis of oxylipins in biofluids, especially in plasma. Only a limited number of studies addressed the analysis of oxylipins in platelets using modern, sensitive LCMS methods, even though these compounds have a huge impact on platelet functions and thrombo-inflammation. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113426DOI Listing

A systematic report on non-coronary cardiac CTA in 1097 patients from the German cardiac CT registry.

Eur J Radiol 2020 Jun 19;130:109136. Epub 2020 Jun 19.

Department of Cardiology, Friedrich-Alexander-Universität Erlangen-Nuernberg, Erlangen, Germany.

Purpose: To prospectively evaluate contemporary indications, safety and diagnostic impact of cardiac CTA in patients undergoing cardiac CTA examinations for non-coronary clinical indications.

Method: We analyzed 1097 consecutive patients from the German Cardiac CT Registry who underwent cardiac CTA between 2009 and 2014 due to clinically indicated non-coronary reasons using 64-slice or newer CT systems in twelve tertiary German heart centers in order to evaluate the impact of clinical indications on procedure-associated parameters. All participating centers electronically submitted patient and examination data including detailed indications, clinical symptoms, procedural parameters, complications and diagnostic results in a predefined template. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109136DOI Listing

Online procurement of pet supplies and willingness to pay for veterinary telemedicine.

Prev Vet Med 2020 Jun 20;181:105073. Epub 2020 Jun 20.

American Veterinary Medical Association, Veterinary Economics Division, 1931N. Meacham Rd. Ste. 100, Schaumburg, IL 60173, United States. Electronic address:

Changing consumer shopping behaviors, and specifically the shift towards online procurement of goods and services, have altered the retail landscape of nearly all goods, including pet products and services. Whilst it is known and commonly discussed that less retail business for products and medications is being conducted in clinics than in the past, it is not well documented where that commerce is now taking place, and by what customer segments. For cats, dogs, and other pets, specialty food and food in general was purchased by a high percentage of respondents at the physical store. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2020.105073DOI Listing

Use of a clay mineral and its nonionic and cationic organoclay derivatives for the removal of pharmaceuticals from rural wastewater effluents.

Chemosphere 2020 Jul 1;259:127480. Epub 2020 Jul 1.

Institut des Sciences de La Terre D'Orléans, UMR 7327, CNRS-Université D'Orléans, 1A Rue de La Férollerie, 45071 Orléans Cedex 2, France; Global Center for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan. Electronic address:

A Na exchanged montmorillonite clay (Na-Mt) and its organoclay derivatives prepared with benzyldimethyltetradecylammonium (BDTA) cationic and polyoxyethylene (20)oleyl-ether (Brij-O20) non-ionic surfactants were used for first time at our knowledge as adsorbents the removal diverse pharmaceuticals (PPs) from samples collected in a rural wastewater facility (town of Josnes in France). The selected facility showed a poor efficiency for the elimination of PPs that were permanently release to the environment. Although involving different interactional mechanisms, the whole adsorbents Na-Mt, nonionic Brij-Mt and cationic BDTA-Mt organoclays, could remove the entire PPs of various chemical nature in a low concentration regime (ng L), where electrostatic interactions mainly controlled the adsorption. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127480DOI Listing

Fabrication porous adsorbents templated from modified sepiolite-stabilized aqueous foams for high-efficient removal of cationic dyes.

Chemosphere 2020 Jun 17;259:126949. Epub 2020 Jun 17.

Key Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, PR China. Electronic address:

High internal phase emulsions (HIPEs) as template for fabrication of porous materials has attracted much attention, due to the high porosity and tunable porous structure. But the enormous consumption of organic solvents is still a nightmare for the practical application. In comparison, the aqueous foam without need any organic solvent and hence has greater advantages in the porous materials preparation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.126949DOI Listing

Application of Artificial Intelligence in COVID-19 drug repurposing.

Diabetes Metab Syndr 2020 Jul 3;14(5):1027-1031. Epub 2020 Jul 3.

School of Electronics Engineering, KIIT University, Bhubaneswar, Odisha, India. Electronic address:

Background And Aim: COVID-19 outbreak has created havoc and a quick cure for the disease will be a therapeutic medicine that has usage history in patients to resolve the current pandemic. With technological advancements in Artificial Intelligence (AI) coupled with increased computational power, the AI-empowered drug repurposing can prove beneficial in the COVID-19 scenario.

Methods: The recent literature is studied and analyzed from various sources such as Scopus, Google Scholar, PubMed, and IEEE Xplore databases. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.068DOI Listing

Causal relationships between substance use and insomnia.

Drug Alcohol Depend 2020 Jul 2;214:108151. Epub 2020 Jul 2.

Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Background: Poor sleep quality and insomnia have been associated with the use of tobacco, alcohol, and cannabis, but it is unclear if there is a causal link. In this Mendelian Randomization (MR) study we examine if insomnia causes substance use and/or if substance use causes insomnia.

Methods: MR uses summary effect estimates from a genome-wide association study (GWAS) to create a genetic instrumental variable for a proposed 'exposure' variable and then identifies that same genetic instrument in an 'outcome' GWAS. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2020.108151DOI Listing

Assessing the environmental sustainability of an emerging energy technology: Solar thermal calcination for cement production.

Sci Total Environ 2020 Jun 26;742:140510. Epub 2020 Jun 26.

Sustainable Industrial Systems, Department of Chemical Engineering and Analytical Science, The University of Manchester, Manchester M13 9PL, UK. Electronic address:

Cement production is a highly energy-intensive process, contributing 7% to global CO emissions. Over 80% of the energy used in cement production is consumed by the calcination process. This paper considers a novel solar thermal technology for calcination, to investigate if it could help mitigate the climate change and other environmental impacts from cement production on a life cycle basis. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140510DOI Listing

The efficacy of predatory fungi on the control of gastrointestinal parasites in domestic and wild animals-A systematic review.

Vet Parasitol 2020 Jun 27;283:109173. Epub 2020 Jun 27.

CIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal. Electronic address:

Background: Gastrointestinal parasites like nematodes are associated with significant impacts on animal health, causing poor growth rates, diseases and even death. Traditional parasite control includes the use of anthelmintic drugs, albeit being associated with drug resistance and ecotoxicity. In the last decade, biological control of parasites using nematophagous or predatory fungi has been increasingly studied, although systematic evidence of its efficacy is still lacking. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109173DOI Listing

Voltage-dependent modulation of TRPA1 currents by diphenhydramine.

Cell Calcium 2020 Jun 21;90:102245. Epub 2020 Jun 21.

Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

Diphenhydramine (DPH) has been broadly used to treat allergy. When used as a topical medicine, DPH temporarily relieves itching and pain. Although transient receptor potential type A1 (TRPA1) channel is known to play roles in both acute and chronic itch and pain, whether DPH affects the activities of TRPA1 remains unclear. Read More

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http://dx.doi.org/10.1016/j.ceca.2020.102245DOI Listing

Antimicrobial and antioxidant activities of defatted Moringa oleifera seed meal extract obtained by ultrasound-assisted extraction and application as a natural antimicrobial coating for raw chicken sausages.

Int J Food Microbiol 2020 Jun 23;332:108770. Epub 2020 Jun 23.

Department of Agro-Industry, Faculty of Agriculture, Natural Resources and Environment, Naresuan University, Phitsanulok 65000, Thailand; Centre of Excellence in Fats and Oils, Faculty of Agriculture, Natural Resources and Environment, Naresuan University, Phitsanulok 65000, Thailand. Electronic address:

Moringa oleifera is a medicinal plant, and its seed oil is known to have high antioxidant properties. The byproduct obtained after oil extraction is called Moringa oleifera seed meal (MoSM), whose potential bioactivity has not been sufficiently documented. Therefore, this study was undertaken with the aim of identifying Moringa oleifera seed meal extract (ME) as a natural antibacterial and antioxidant alternative. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108770DOI Listing

Effects of gamma irradiation on the shelf-life and bioactive compounds of Tuber aestivum truffles packaged in passive modified atmosphere.

Int J Food Microbiol 2020 Jul 2;332:108774. Epub 2020 Jul 2.

Forest Resources Department, Agrifood Research and Technology Centre of Aragon (CITA), Agrifood Institute of Aragón - IA2 (CITA-Zaragoza University), Zaragoza, Spain.

The effects of gamma irradiation (0.5, 1.0, 1. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108774DOI Listing

Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential.

Eur J Med Chem 2020 Jul 2;202:112603. Epub 2020 Jul 2.

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth's College of Pharmacy, Navi Mumbai, Maharashtra, India. Electronic address:

Cancer cells increase their glucose uptake and glycolytic activity to meet the high energy requirements of proliferation. Glucose transporters (GLUTs), which facilitate the transport of glucose and related hexoses across the cell membrane, play a vital role in tumor cell survival and are overexpressed in various cancers. GLUT1, the most overexpressed GLUT in many cancers, is emerging as a promising anti-cancer target. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112603DOI Listing

Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi's sarcoma-associated herpesvirus infections.

Eur J Med Chem 2020 Jun 28;202:112525. Epub 2020 Jun 28.

Department of Drug Design and Optimization (DDOP), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123, Saarbrücken, Germany; Department of Pharmacy, Saarland University, Campus E8.1, 66123, Saarbrücken, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 66123, Saarbrücken, Germany. Electronic address:

The Latency-associated nuclear antigen (LANA) plays a central role for the latent persistence of the Kaposi's Sarcoma Herpesvirus (KSHV) in the human host and helps to establish lifelong infections. Herein, we report our efforts towards hit-to-lead generation starting from a previously discovered LANA-DNA inhibitor. By tethering the viral genome to the host nucleosomes, LANA ensures the segregation and persistence of the viral DNA during mitosis. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112525DOI Listing

Metagenomics approach the intestinal microbiome structure and function in the anti-H1N1 of a traditional chinese medicine acid polysaccharide.

Microb Pathog 2020 Jul 4:104351. Epub 2020 Jul 4.

Heilongjiang University of Chinese Medicine, Key Laboratory of Basic and Applied Research in North Medicine, Ministry of Education, Heilongjiang Key Laboratory of Drug Efficacy Study Material of Traditional Chinese Medicine and Natural Product, Harbin, 150040, China. Electronic address:

Ephedra sinica Stapf polysaccharide is a pure acidic uniform polysaccharide extracted from the traditional Chinese medicine Ephedra sinica Stapf. In our past research, it was found that it has anti-inflammatory response and suppresses immunity. Therefore, in this experiment, mice were infected with FM1 virus, treated with Ephedra sinica Stapf polysaccharide, and metagene sequencing was used to sequence the mouse intestinal contents. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104351DOI Listing

Estimation of the probable outbreak size of novel coronavirus (COVID-19) in social gathering events and industrial activities.

Int J Infect Dis 2020 Jul 4. Epub 2020 Jul 4.

Jordan Food and Drug Administration, 11181, Amman, Jordan. Electronic address:

Background: The reproduction number (R0) is vital in epidemiology to estimate the number infected people and trace the close contacts. The R0 values varies depending on social activity and type of gathering events that induce infection transmissibility, in addition to its pathophysiology dependence.

Objectives: In this study, we estimated the probable outbreak size of COVID-19 at clusters mathematically using a simple model that can predict the number of COVID-19 cases, as a function of time. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.105DOI Listing

Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.

Mol Cell Probes 2020 Jul 4:101636. Epub 2020 Jul 4.

Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Read More

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http://dx.doi.org/10.1016/j.mcp.2020.101636DOI Listing

Should Short-course Neoadjuvant Radiotherapy Be Applied for Low-lying Rectal Cancer? A Systematic Review and Meta-analysis of the Randomized Trials.

Int J Radiat Oncol Biol Phys 2020 Jul 4. Epub 2020 Jul 4.

Department of Radiotherapy I, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Background: National Comprehensive Cancer Network guidelines recommend either long-course chemoradiation (LC) or short-course radiation (SC, 5 × 5 Gy) for rectal cancer before total mesorectal excision. However, they do not recommend SC for low-lying tumors. As early toxicity of SC is lower than that of LC, and postoperative complications as well as late toxicity are similar, the probable reason is a notion that for low-lying tumors LC may be more effective than SC in assuring local control. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.077DOI Listing

Prediction of MGMT Status for Glioblastoma Patients Using Radiomics Feature Extraction from F-DOPA-PET Imaging.

Int J Radiat Oncol Biol Phys 2020 Jul 4. Epub 2020 Jul 4.

Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Purpose: Methylation of the O-methylguanine methyltransferase (MGMT) gene promoter is associated with improved treatment response and survival in patients with Glioblastoma (GB), but the necessary pathological specimen can be non-diagnostic. In this study, we assessed whether radiomics features from pre-treatment F-DOPA PET imaging could be used to predict pathologic MGMT status.

Methods: This study included 86 patients with newly diagnosed GB, split into three groups (training, validating, predicting). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.06.073DOI Listing

Longitudinal Analysis of Depression and Anxiety Symptoms as Independent Predictors of Neurocognitive Function in Primary Brain Tumor Patients.

Int J Radiat Oncol Biol Phys 2020 Jul 4. Epub 2020 Jul 4.

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA. Electronic address:

Background: Primary brain tumor patients are vulnerable to depression and anxiety symptoms, which may affect their neurocognitive functioning. We performed a prospective longitudinal analysis to examine the association between depression and anxiety symptoms and domain-specific neurocognitive functioning in primary brain tumor patients receiving radiation therapy [RT].

Methods: On a prospective trial, 54 primary brain tumor patients receiving RT underwent comprehensive neurocognitive evaluation at baseline (pre-RT), and 3, 6, and 12 months post-RT. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.07.002DOI Listing

Nanoscale infrared probing of amyloid formation within the pleomorphic adenoma tissue.

Biochim Biophys Acta Gen Subj 2020 Jul 4:129677. Epub 2020 Jul 4.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.

Background: The process of malignant transformations of many tumour cases is still unclear and more specific experimental approaches are necessary. The detailed identification of the pathological changes may help in the therapy progression through the development of drugs with more selective action.

Methods: In this study, the AFM-IR nanospectroscopy was applied for the first time to the pleomorphic adenoma (TM) and the marginal tissue characterizations. Read More

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http://dx.doi.org/10.1016/j.bbagen.2020.129677DOI Listing

Zwitterion composite chitosan-epichlorohydrin/zeolite for adsorption of methylene blue and reactive red 120 dyes.

Int J Biol Macromol 2020 Jul 4. Epub 2020 Jul 4.

Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam.

In this research, an attempt to develop zwitterion composite adsorbent is conducted by modifying chitosan (CHS) with a covalent cross-linker (epichlorohydrin, ECH) and an aluminosilicate mineral (zeolite, ZL). The zwitterion composite adsorbent of chitosan-epichlorohydrin/zeolite (CHS-ECH/ZL) is performed multifunctional tasks by removing two structurally different cationic (methylene blue dye, MB), and anionic (reactive red 120 dye, RR120) dyes from aqueous solutions. The surface property, crystallinity, morphology, functionality, and charge of the CHS-ECH/ZL are analyzed using BET, XRD, SEM, FTIR, and pH, analyses. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.014DOI Listing

Blood carbon dioxide tension and risk in pulmonary arterial hypertension.

Int J Cardiol 2020 Jul 4. Epub 2020 Jul 4.

Abteilung für Pneumologie, II. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Background: Low partial pressure of blood carbon dioxide (PCO) is common in patients with pulmonary arterial hypertension (PAH) and may inform on clinical outcomes. We investigated whether PCO measurements could provide prognostic information in addition to standard risk assessment in this group of patients.

Methods: We conducted a retrospective observational cohort study on patients with newly diagnosed idiopathic, heritable or drug/toxin-induced PAH recruited from two European centres. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.069DOI Listing

Detecting caries lesions of different radiographic extension on bitewings using deep learning.

J Dent 2020 Jul 4:103425. Epub 2020 Jul 4.

Department of Oral Diagnostics, Digital Health and Health Services Research, Charité - Universitätsmedizin Berlin, Germany. Electronic address:

Objectives: We aimed to apply deep learning to detect caries lesions of different radiographic extension on bitewings, hypothesizing it to be significantly more accurate than individual dentists.

Methods: 3,686 bitewing radiographs were assessed by four experienced dentists. Caries lesions were marked in a pixelwise fashion. Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103425DOI Listing

The protective effect of Xanthoceras sorbifolia Bunge husks on cognitive disorder based on metabolomics and gut microbiota analysis.

J Ethnopharmacol 2020 Jul 4:113094. Epub 2020 Jul 4.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China; National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control, China.

Aim Of The Study: The husks of Xanthoceras sorbifolia Bunge mainly used in north China as folk medicine were reported to have potential protective effect on cognitive impairment. However, the mechanism remains unclear. In order to fully understand the mechanism of the protection, a complementary study of the husks was conducted. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113094DOI Listing

Silymarin sex-dependently improves cognitive functions and alters TNF-α, BDNF, and glutamate in the hippocampus of mice with mild traumatic brain injury.

Life Sci 2020 Jul 4:118049. Epub 2020 Jul 4.

Salari Institute of Cognitive and Behavioral Disorders, Alborz, Iran. Electronic address:

Aims: Mild traumatic brain injury (mTBI) is an important risk factor for cognitive impairment. Despite intense efforts to develop efficient treatments, the current therapies are not often effective and far from satisfactory. Silymarin has been suggested as a therapeutic agent in the treatment of traumatic brain injury. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118049DOI Listing

Inhibition of miR-34a reduces cellular senescence in human adipose tissue-derived mesenchymal stem cells through the activation of SIRT1.

Life Sci 2020 Jul 4:118055. Epub 2020 Jul 4.

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Aims: Human adipose derived mesenchymal stem cells (hAD-MSCs) as the most promising target for cell therapy and regenerative medicine, face senescence as a major drawback resulting in their limited proliferation and differentiation potentials. To evaluate the efficacy of miR-34a silencing as an anti-senescence strategy in hAD-MSCs, in this study common hallmarks of senescence were assessed after transient inhibition of miR-34a in hAD-MSCs.

Materials And Methods: The expression levels of miR-34a in hAD-MSCs at different passages were evaluated by real-time quantitative PCR. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118055DOI Listing

How geographic productivity patterns affect food-web evolution.

J Theor Biol 2020 Jul 4:110374. Epub 2020 Jul 4.

Integrated Science Lab, Department of Mathematics and Mathematical Statistics, UmeåUniversity, SE-90187 Umeå, Sweden; Evolution and Ecology Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361 Laxenburg, Austria.

It is well recognized that spatial heterogeneity and overall productivity have important consequences for the diversity and community structure of food webs. Yet, few, if any, studies have considered the effects of heterogeneous spatial distributions of primary production. Here, we theoretically investigate how the variance and autocorrelation length of primary production affect properties of evolved food webs consisting of one autotroph and several heterotrophs. Read More

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http://dx.doi.org/10.1016/j.jtbi.2020.110374DOI Listing

A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program.

Cell Syst 2020 Jun 29. Epub 2020 Jun 29.

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK; Centre for Trophoblast Research University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic development that coincides with extensive epigenetic reprogramming. Complex manipulation techniques and maternal stores of proteins preclude large-scale functional screens for ZGA regulators within early embryos. Here, we combined pooled CRISPR activation (CRISPRa) with single-cell transcriptomics to identify regulators of ZGA-like transcription in mouse embryonic stem cells, which serve as a tractable, in vitro proxy of early mouse embryos. Read More

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http://dx.doi.org/10.1016/j.cels.2020.06.004DOI Listing

The nuclear envelope: LINCing tissue mechanics to genome regulation in cardiac and skeletal muscle.

Biol Lett 2020 Jul 8;16(7):20200302. Epub 2020 Jul 8.

School of Cardiovascular Medicine and Sciences, King's College London, London SE5 9NU, UK.

Regulation of the genome is viewed through the prism of gene expression, DNA replication and DNA repair as controlled through transcription, chromatin compartmentalisation and recruitment of repair factors by enzymes such as DNA polymerases, ligases, acetylases, methylases and cyclin-dependent kinases. However, recent advances in the field of muscle cell physiology have also shown a compelling role for 'outside-in' biophysical control of genomic material through mechanotransduction. The crucial hub that transduces these biophysical signals is called the Linker of Nucleoskeleton and Cytoskeleton (LINC). Read More

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http://dx.doi.org/10.1098/rsbl.2020.0302DOI Listing

Bumblebee hairs as electric and air motion sensors: theoretical analysis of an isolated hair.

Authors:
K Koh D Robert

J R Soc Interface 2020 Jul 8;17(168):20200146. Epub 2020 Jul 8.

School of Biological Sciences, University of Bristol, Bristol, UK.

Foraging bumblebees are electrically charged. Charge accumulation has been proposed to enable their ability to detect and react to electrical cues. One mechanism suggested for bumblebee electro-sensing is the interaction between external electric fields and electric charges accumulating on fine hairs on the cuticular body. Read More

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http://dx.doi.org/10.1098/rsif.2020.0146DOI Listing

Thoracoscopic Transdiaphragmatic Excision of Hepatic Hydatid in Patients with Synchronous Pulmonary Hydatid: A Novel Operative Approach.

J Laparoendosc Adv Surg Tech A 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

We wish to describe a novel technique of transdiaphragmatic excision of hepatic hydatid in patients with synchronous ipsilateral lung hydatid. Two patients, aged 11 and 6 years, presented with large synchronous hydatid cyst in right lung and liver. Second patient had two large cysts in right lobe of liver in posterior-superior segment of VII and VIII. Read More

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http://dx.doi.org/10.1089/lap.2020.0228DOI Listing

A Comprehensive Targeted Metabolomic Assay for Urine Analysis.

Anal Chem 2020 Jul 7. Epub 2020 Jul 7.

Among all the human biological fluids used for disease biomarker discovery or clinical chemistry, urine stands out. It can be col-lected easily and non-invasively, it is readily available in large volumes, it is typically free from protein contamination and it is chemically complex - reflecting a wide range of physiological states and functions. However, the comprehensive metabolomic analysis of urine has been somewhat less studied compared to blood. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c01682DOI Listing

Infrared Thin Film Detectors Based on Thermo-Responsive Microgels with Linear Shrinkage Behavior and Gold Nanorods.

ACS Appl Mater Interfaces 2020 Jul 7. Epub 2020 Jul 7.

To overcome the drawbacks of existing infrared detectors, infrared thin film detectors based on microgels and gold nanorods (Au NRs) are investigated. The microgels with a linear shrinkage of the hydrodynamic diameter (D) between 10 and 55 C are copolymerized by monomers di(ethylene glycol) methyl ether methacrylate (MEOMA), oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and acrylic acid (AA) with a molar ratio of 1:1:1. Homogenous thin films are obtained by spin coating from aqueous solution on silicon substrates. Read More

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http://dx.doi.org/10.1021/acsami.0c08049DOI Listing

PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer.

Prostate 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology (HUS Diagnostic Center) and Medicum, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Conventional systematic prostate biopsies (SBx) have multiple limitations, and magnetic resonance imaging (MRI)-ultrasound fusion targeting is increasingly applied (fusion biopsies [FBx]). In our previous studies, we have shown that loss of the tumor suppressor gene phosphatase and tensin homolog (PTEN) in radical prostatectomy (RP) specimens predicts poor disease-specific survival, and in active surveillance (AS), PTEN loss in SBx predicts an adverse AS outcome, although SBx PTEN status does not correlate well with the corresponding RP status. Here, we have hypothesized that PTEN and erythroblast transformation-specific related gene (ERG) status in FBx correlate better with RP than they would in SBx. Read More

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http://dx.doi.org/10.1002/pros.24040DOI Listing

Engineered Anisotropic Fluids of Rare Earth Nanomaterials.

Angew Chem Int Ed Engl 2020 Jul 7. Epub 2020 Jul 7.

Tsinghua University, Department of Chemistry, Shuangqing road, 100084, Beijing, CHINA.

The self-assembly of inorganic nanoparticles into well-ordered structures in the absence of solvents is generally hindered by van der Waals forces, leading to random aggregates between them. To address the problem, we functionalized rigid rare earth (RE) nanoparticles with a layer of flexible polymers by electrostatic complexation. Consequently, an ordered and solvent-free liquid crystal (LC) state of RE nanoparticles was realized. Read More

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http://dx.doi.org/10.1002/anie.202007676DOI Listing

Effectiveness of a Novel, Rechargeable, Polycationic N-halamine Antibacterial Coating on Listeria Monocytogenes Survival in Food Processing Environments.

J Food Prot 2020 Jul 7. Epub 2020 Jul 7.

University of Manitoba Elizabeth Dafoe Library Associate Professor Food and Human Nutritional Sciences 13 Freedman crescent CANADA Winnipeg Manitoba R3T 2N2 2044746658.

The goal of this research was to evaluate the efficacy of a novel rechargeable non-leaching polycationic N-halamine coating applied to stainless steel (STEEL) food contact surfaces to reduce Listeria monocytogenes contamination on ready-to-eat (RTE) foods. For this purpose, four L. monocytogenes strains were inoculated onto the charged (C; chlorine-activated) or uncharged (NC) N-halamine coated STEEL coupon surfaces (intact vs. Read More

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http://dx.doi.org/10.4315/JFP-20-084DOI Listing

Cloning, characterization, and functional analysis of chitinase-like protein 1 in the shell of Pinctada fucata.

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Biomineralization, especially shell formation, is a sophisticated process regulated by various matrix proteins. Pinctada fucata chitinase-like protein 1 (Pf-Clp1), which belongs to the GH18 family, was discovered by our group using in-depth proteomic analysis. However, its function is still unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmaa076DOI Listing

A Case of Acute Lymphocytic Leukaemia with t(3;13) and Central Nervous System Leukemia after Allogenic Cord Blood Transplantation.

Cell Med 2019 4;11:2155179019873850. Epub 2019 Sep 4.

Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, P.R. China.

Background: Acute lymphoblastic leukemia (ALL) is a neoplastic cancer characterized by clonal expansion of leukemic cells in lymph organs and bone marrow. Lots of kinds of different chromosomal translocations can be found in those leukemic cells. However, the role of abnormal chromosomes and genes in leukemogenesis is not yet fully understood. Read More

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http://dx.doi.org/10.1177/2155179019873850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728670PMC
September 2019

Integration of molecular networking and fingerprint analysis for studying constituents in Microctis Folium.

PLoS One 2020 7;15(7):e0235533. Epub 2020 Jul 7.

Guangdong Engineering & Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Microctis Folium is the dried leaves of a plant (Microcos paniculata L.) used to improve the digestive system, alleviate diarrhoea, and relieve fever, but information regarding its chemical composition has rarely been reported. The traditional research approach of determining chemical composition has included isolating, purifying, and identifying compounds with high-cost and time-consuming processes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235533PLOS

A three-dimensional (3-D) meshfree-based computational model to investigate stress-strain-time relationships of plant cells during drying.

PLoS One 2020 7;15(7):e0235712. Epub 2020 Jul 7.

Science and Engineering Faculty, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, Australia.

A better understanding of plant cell micromechanics would enhance the current opinion on "how things are happening" inside a plant cell, enabling more detailed insights into plant physiology as well as processing plant biomaterials. However, with the contemporary laboratory equipment, the experimental investigation of cell micromechanics has been a challenging task due to diminutive spatial and time scales involved. In this investigation, a three-dimensional (3-D) coupled Smoothed Particle Hydrodynamics (SPH) and Coarse-Grained (CG) computational approach has been employed to model micromechanics of single plant cells going through drying or dehydration. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235712PLOS

Differential impacts of carp and salmon pituitary extracts on induced oogenesis, egg quality, molecular ontogeny and embryonic developmental competence in European eel.

PLoS One 2020 7;15(7):e0235617. Epub 2020 Jul 7.

National Institute of Aquatic Resources, Technical University of Denmark, Kgs. Lyngby, Denmark.

Low egg quality and embryonic survival are critical challenges in aquaculture, where assisted reproduction procedures and other factors may impact egg quality. This includes European eel (Anguilla anguilla), where pituitary extract from carp (CPE) or salmon (SPE) is applied to override a dopaminergic inhibition of the neuroendocrine system, preventing gonadotropin secretion and gonadal development. The present study used either CPE or SPE to induce vitellogenesis in female European eel and compared impacts on egg quality and offspring developmental competence with emphasis on the maternal-to-zygotic transition (MZT). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235617PLOS

Modeling predator and prey hotspots: Management implications of baleen whale co-occurrence with krill in Central California.

PLoS One 2020 7;15(7):e0235603. Epub 2020 Jul 7.

Point Blue Conservation Science, Petaluma, CA, United States of America.

As global ocean-bound commerce increases, managing human activities has become important in reducing conflict with threatened wildlife. This study investigates environmental factors determining abundance and distribution of blue whales (Balaenoptera musculus), humpback whales (Megaptera novaeangliae) and their prey (Euphausia pacifica and Thysanoessa spinifera) in central California. We provide insights into environmental drivers of the ecology and distribution of these species, model whale distributions and determine coincident hotspots of whales and their prey that will help decrease human threats to whales and protect critical feeding habitat. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235603PLOS
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