927,035 results match your criteria Applied Cardiopulmonary Pathophysiology[Journal]


Cranberry juice decreases disease activity in women with rheumatoid arthritis.

Nutrition 2018 Oct 10;60:112-117. Epub 2018 Oct 10.

Department of Internal Medicine,University of Londrina, Londrina, Paraná, Brazil. Electronic address:

Objectives: Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.

Methods: A prospective study was conducted with 41 women diagnosed with RA. Read More

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October 2018

An approach to identifying the relative importance of different radionuclides in ecological radiological risk assessment: Application to nuclear power plant releases.

J Environ Radioact 2018 Dec 12;197:116-126. Epub 2018 Dec 12.

IRSN, PSE-ENV, Fontenay aux Roses, France.

There is a need to prioritise the requirements for data to assess the radiological risk for fauna and flora, as inevitable large data gaps occur due to the large number of combinations of radionuclides and organisms for which doses need to be assessed. The potentially most important dose-forming radionuclide-pathways combinations need to be identified to optimize filling these gaps. Few attempts have been made to classify the importance of isotopes with regard to radiation protection of the environment. Read More

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December 2018

Optimizing denaturing HPLC as a robust technique for identification of Short Tandem Repeats (STR) in forensic medicine.

J Forensic Leg Med 2018 Dec 10;61:108-114. Epub 2018 Dec 10.

Department and Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran. Electronic address:

Introduction: Short Tandem Repeats (STRs) are defined as short lengths of 2-7 base pairs spreading through human genome which due to their highly diverse individually distribution are widely applied for identity detection and other forensic medicine purposes. Burdening considerable costs by the conventional methods such as capillary electrophoresis, we aimed to compare concomitant usage of multiplex PCR and denaturing high-performance liquid chromatography (DHPLC) as cheap, fast, highly accurate, and more accessible methods, with capillary electrophoresis (CE) to evaluate their potential for early screening of STRs.

Materials And Methods: The present study randomly included 20 blood samples from the subjects referred to forensic medicine of Semnan, Iran. Read More

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December 2018

Stored potential energy increases and elastic properties alterations are produced after restoring dentin with Zn-containing amalgams.

J Mech Behav Biomed Mater 2018 Dec 6;91:109-121. Epub 2018 Dec 6.

University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.

The aim of this research was to ascertain the mechanical and chemical behavior of sound and caries-affected dentin (CAD), after the placement of Zn-free vs containing amalgam restorations. Peritubular and intertubular dentin were evaluated using, a) nanoindenter in scanning mode; the load and displacement responses were used to perform the nano-Dynamic mechanical analysis and to estimate the complex (E * ) and storage modulus (E'); b) Raman spectroscopy was used to describe the hierarchical cluster analysis (HCA). Assessments were performed before restoration placement and after restoring, and after 3 months of storage with thermocycling (100,000cy/5 °C and 55 °C). Read More

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December 2018

Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.

Environ Int 2018 Dec 12;123:301-309. Epub 2018 Dec 12.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. Read More

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December 2018

Proteomic analysis for phenanthrene-elicited wheat chloroplast deformation.

Environ Int 2018 Dec 11;123:273-281. Epub 2018 Dec 11.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA.

The exposure of polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis. Thus, we hypothesize that chloroplast inner structure damage is the reason for leaf chlorosis. This study was conducted with the wheat seedlings exposed to Hoagland nutrient solution containing 1. Read More

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December 2018

An update on Drug Repurposing: Re-written saga of the drug's fate.

Biomed Pharmacother 2018 Dec 12;110:700-716. Epub 2018 Dec 12.

Pharamacological Modelling and Simulation Centre, M.S.Ramaiah University of Applied Sciences, Bangalore, Karnataka, India; Department of Pharmacy Practice, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.

Drug repurposing is an unconventional drug discovery approach to explore new therapeutic benefits of existing, shelved and the drugs in clinical trials. This approach is currently emerging to overcome the bottleneck constraints faced during traditional drug discovery in grounds of financial support, timeline and resources. In this direction, several efforts were made for the construction of stratagems based on bioinformatics and computational tools to intensify the repurposing process off-late. Read More

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December 2018

Evaluation of an untargeted chemometric approach for the source inference of ignitable liquids in forensic science.

Forensic Sci Int 2018 Dec 5;295:8-18. Epub 2018 Dec 5.

UMR Ingénierie Procédés Aliments, AgroParisTech, Inra, Université Paris-Saclay, 91300 Massy, France. Electronic address:

Recent research efforts in the domain of fire debris analysis have been mainly oriented towards the development of innovative analytical procedures and chemometric approaches for the detection and classification of ignitable liquids in fire specimens according to the ASTM E1618. However, less attention has been brought to the question of the source inference of ignitable liquids. Infer the identity of source of ignitable liquids recovered from arson sites is still a challenging and ongoing research area. Read More

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December 2018

The state of bereavement support in adult intensive care: A systematic review and narrative synthesis.

J Crit Care 2018 Dec 1;50:177-187. Epub 2018 Dec 1.

University of Ottawa, Faculty of Health Sciences, School of Nursing, 3245B Roger Guindon Hall, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:

Purpose: Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first review to investigate the state of ICU bereavement support globally, and the availability and effectiveness of bereavement support interventions.

Methods: A systematic review and narrative synthesis. Read More

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December 2018

A comparison between physical and biopsychosocial measures of frailty: Prevalence and associated factors in Brazilian older adults.

Arch Gerontol Geriatr 2018 Dec 6;81:111-118. Epub 2018 Dec 6.

National School of Public Health/Oswaldo Cruz Foundation, Department of Epidemiology and Quantitative Methods, Rua Leopoldo Bulhões, 1480/room 817b, Manguinhos, 21041-210 Rio de Janeiro, RJ, Brazil. Electronic address:

Purpose: To estimate the prevalence of frailty, according to Tilburg Frailty Indicator (TFI) and CHS index, to investigate the correlation between both instruments and to identify the factors associated with this condition in older users of primary health care.

Methods: This is a sectional study with 302 individuals aged 60 years or more of Rio de Janeiro/Brazil. Sociodemographic, health, functional dependence and lifestyle variables were collected. Read More

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December 2018

Perceptual size discrimination requires awareness and late visual areas: A continuous flash suppression and interocular transfer study.

Conscious Cogn 2018 Dec 11;67:77-85. Epub 2018 Dec 11.

Department of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia. Electronic address:

We applied continuous flash suppression (CFS) during an interocular transfer paradigm to evaluate the importance of awareness and the contribution of early versus late visual structures in size recognition. Specifically, we tested if size judgements of a visible target could be influenced by a congruent or incongruent prime presented to the same or different eye. Without CFS, participants categorised a target as "small" or "large" more quickly when it was preceded by a congruent prime - regardless of whether the prime and target were presented to the same or different eye. Read More

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December 2018

Reversible hydrogen adsorption on Li-decorated T-graphene flake: The effect of electric field.

J Mol Graph Model 2018 Dec 8;87:192-196. Epub 2018 Dec 8.

Department of Chemistry, College of Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

In the present work, we have studied a new allotrope of graphene, denoted as T-graphene (TG) flake as a versatile material in hydrogen storage. Recently, the metallic character of TG has been revealed. Our results show that the Li-decoration has a significant effect on the electronic properties of TG flake. Read More

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December 2018

Two coumarin-based turn-on fluorescent probes based on for hypochlorous acid detection and imaging in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 10;211:239-245. Epub 2018 Dec 10.

School of Pharmacy, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers' University, Yancheng, Jiangsu 224051, People's Republic of China.

This work, two turn-on fluorescent probes (3-acetyl-2H-chromen-2-one (ACO) & (1E)-1-(1-(2-oxo-2H-chromen-3-yl)ethylidene)thiosemicarbazide (CETC)) based on coumarin have been designed and synthesized, which could selectively and sensitively recognize ClO with fast response time. ACO &CETC were almost non fluorescent possibly due to both the lacton form of coumarin and unbridged CN bonds which can undergo a nonradiative decay process in the excited state. Upon the addition of ClO, ACO &CETC were oxidized to ring - opened by cleavage the CO and CN and the fluorescence intensity were increased considerably. Read More

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December 2018

Surface plasmon resonance of gold nanoparticles as a colorimetric sensor for indirect detection of Cefixime.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:234-238. Epub 2018 Dec 4.

Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Electronic address:

This study reports a colorimetric sensor with excellent sensitivity to detect Cefixime base on gold nanoparticles. Cefixime is an antibiotic which has a wide range of applications in medicine. Cefixime did not change the surface plasmon resonance bond in gold nanoparticles solution; therefore, there was no change in the color solution of gold nanoparticles. Read More

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December 2018

Weighted vest effects on impact forces and joint work during vertical jump landings in men and women.

Hum Mov Sci 2018 Dec 12;63:156-163. Epub 2018 Dec 12.

Department of Kinesiology & Nutrition Sciences, University of Nevada, Las Vegas, 4505 S. Maryland Parkway, Box 3034, Las Vegas, NV 89154, USA.

Weighted vest (WV) use during vertical jump landings (VJL) does not appear to alter peak vertical ground reaction forces (GRF) or peak joint torques. However, WV effects on joint work and sex differences during VJL are not well understood. This study assessed WV effects on vertical GRF and sagittal joint work during VJL in men and women. Read More

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December 2018

Effect of taping and its conditions on electromyographic responses of knee extensor muscles.

Authors:
Kohei Watanabe

Hum Mov Sci 2018 Dec 12;63:148-155. Epub 2018 Dec 12.

Laboratory of Neuromuscular Biomechanics, School of International Liberal Studies, Chukyo University, Nagoya, Japan. Electronic address:

Introduction: The present study investigated the effect of stretchable characteristics of elastic therapeutic tape and its elongation on surface electromyography (EMG) of knee extensor muscles during knee extension movements.

Methods: Nine healthy men performed knee extension movement with the application of normal elastic tape or highly stretchable tape and without the tapes (control). Tapes were applied on the anterior thigh to cross the knee joint with no elongation and elongation of 50 and 75% of the maximum stretchability. Read More

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December 2018

Successful genetic modification of porcine spermatogonial stem cells via an electrically responsive Au nanowire injector.

Biomaterials 2018 Dec 10;193:22-29. Epub 2018 Dec 10.

Department of Animal Life Science, Kangwon National University, Chuncheon, 24341, South Korea; Department of Applied Animal Science, Kangwon National University, Chuncheon, 24341, South Korea. Electronic address:

Transgenic pigs are quite useful in many biomedical fields, such as xenotransplantation research and the production of biopharmaceutical materials. The genetic transformation of porcine spermatogonial stem cells (pSSCs) followed by differentiation into mature spermatozoa enables the effective production of transgenic pigs. Improving the transfection efficiency of pSSCs, however, has been much desired. Read More

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December 2018

Identification and function of extracellular protein in wastewater treatment using proteomic approaches: A minireview.

J Environ Manage 2018 Dec 12;233:24-29. Epub 2018 Dec 12.

College of Environment and Resources, Xiangtan University, Xiangtan, 411105, China. Electronic address:

Microbial extracellular proteins serve as important functions in wastewater treatment process. Analysis of their compositions and properties is crucial to probe their specific functions. However, conventional analytical techniques cannot obtain interest protein information from complex proteins. Read More

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December 2018

A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study.

J Pharm Biomed Anal 2018 Dec 10;165:198-206. Epub 2018 Dec 10.

Bioanalytical Sciences, Bristol-Myers Squibb, Princeton, NJ, 08543, USA.

Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography-mass spectrometry (LC-MS) bioanalytical assays. Recently, the application of SIL drugs and LC-MS assays to microdose absolute bioavailability (BA) studies has gained increasing attention. This approach can provide significant cost and time saving, and higher data quality compared to the accelerator mass spectrometry (AMS)-based method, since it avoids the use of radioactive drug, high-cost AMS instrumentation and complex measurement processes. Read More

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December 2018

Color-sensitive and spectrometer-free plasmonic sensor for biosensing applications.

Biosens Bioelectron 2018 Dec 7;126:743-750. Epub 2018 Dec 7.

Department of Information and Communication Engineering, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, Republic of Korea. Electronic address:

A color-sensitive and spectrometer-free sensing method using plasmonic nanohole arrays and the color components, L* , a* , and b* , of the CIELAB defined by the international commission on illumination (CIE) is introduced for the analysis of optically transparent materials in the visible range. Spectral analysis based on plasmonic nanoparticles or nanostructures can be applied to real-time bio-detection, but complex optical instrumentations and low spatial resolution have limited the sensing ability. Therefore, we take an advantage of color image processing instead of spectral analysis which induces the distinctive color information of plasmonic nanohole arrays with different transparent materials. Read More

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December 2018

Improved SILAC method for double labeling of bacterial proteome.

J Proteomics 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address:

Stable isotope labeling with amino acids in cell culture (SILAC) is a robust proteomics method with advantages such as reproducibility and easy handling. This method is popular for the analysis of mammalian cells. However, amino acid conversion in bacteria decreases the labeling efficiency and quantification accuracy, limiting the application of SILAC in bacterial proteomics to auxotrophic bacteria or to single labeling with lysine. Read More

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December 2018

Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

Accurate parcellation and labeling of primary cortical sulci in the human fetal brain is useful for regional analysis of brain development. However, human fetal brains show large spatio-temporal changes in brain size, cortical folding patterns, and relative position/size of cortical regions, making accurate automatic sulcal labeling challenging. Here, we introduce a novel sulcal labeling method for the fetal brain using spatio-temporal gyrification information from multiple fetal templates. Read More

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December 2018

PF CAT Outcomes in Diabetic Lumbar Spine Surgical Patients.

Spine J 2018 Dec 12. Epub 2018 Dec 12.

University of Utah Department of Orthopaedic Surgery, 590 Wakara Way, Salt Lake City, UT 84108. Electronic address:

Background Context: Diabetes is a highly prevalent comorbid condition among patients undergoing spine surgery. Several studies have used legacy patient-reported outcome measures to implicate diabetes as a predictor of increased disability, pain, and decreased physical function and quality of life following spine surgery. The effect of diabetes on postoperative physical function has not yet been studied using the PROMIS Physical Function Computer Adaptive Test (PF CAT). Read More

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December 2018

Enhanced remedial effects for vitamin D and calcium co-supplementation against pre-existing lead nephrotoxicity in mice: The roles of renal calcium homeostatic molecules.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia. Electronic address:

Background: Lead (Pb) is a toxic heavy metal and nephropathy is common with chronic exposure. Although vitamin D (VD) and calcium (Ca) showed promising protections, their co-administration was not previously investigated in Pb nephrotoxicity. This study measured the potential interactions and remedial effects of VD and/or Ca on established Pb nephropathy. Read More

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December 2018

Protocol for evaluation of topical ophthalmic drug products in different compartments of fresh eye tissues in a rabbit model.

J Pharmacol Toxicol Methods 2018 Dec 12. Epub 2018 Dec 12.

Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address:

Topical ophthalmic drugs are the most commonly used dosage form to treat diseases of the anterior segment of the eye. Although this dosage form has the advantages of ease of application, small volume dose, and rapid action and is largely devoid of systemic adverse effects, the bioavailability is low due to pre-corneal anatomical barriers and the nature of the drug formulation itself. Some complex generic formulations (suspensions, ointments, gels) for topical ophthalmic products face impediments to rapid regulatory approval because of the complex nature of the formulations and difficulties in determining bioequivalence with the innovator product. Read More

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December 2018

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

J Control Release 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark. Electronic address:

Albumin is a highly successful tool of drug delivery providing drastically extended body and blood residence time for the associated cargo, but it only traffics single drug copies at a time. In turn, macromolecular prodrugs (MP) are advantaged in carrying a high drug payload but offering only a modest extension of residence time to the conjugated drugs. In this work, we engineer MP to contain terminal groups that bind to albumin via non-covalent association and reveal that this facile measure affords a significant protraction for the associated polymers. Read More

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December 2018

Transcranial static magnetic stimulation over the primary motor cortex alters sequential implicit motor learning.

Neurosci Lett 2018 Dec 12. Epub 2018 Dec 12.

Graduate School of Core Ethics and Frontier Sciences, Ritsumeikan University, Japan. Electronic address:

Transcranial static magnetic stimulation (tSMS) is a recently introduced noninvasive brain stimulation technique that can modulate brain excitability. Here, we investigated a hypothesis that motor learning would be altered by tSMS applied to the primary motor cortex (M1). For motor task, we chose a serial reaction time task consisting of sequential trials and random trials in which the visual cue doesn't play out a repeating pattern of positions to evaluate an implicit motor learning, where the M1 is a key structure for skill acquisition and early consolidation. Read More

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December 2018

Human olfactory stem cells: As a promising source of dopaminergic neuron-like cells for treatment of Parkinson's disease.

Neurosci Lett 2018 Dec 12. Epub 2018 Dec 12.

Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address:

The production of dopaminergic (DA) neurons from stem cells holds a great promise for future clinical treatment of neurodegenerative diseases, such as Parkinson's disease (PD). Olfactory ecto-mesenchymal stem cells (OE-MSCs) derived from the adult human olfactory mucosa can be easily isolated and expanded in culture while maintaining their immense plasticity. In addition to reduced ethical concerns, OE-MSCs could be transplanted across allogeneic barriers, making them desirable stem cells for clinical applications. Read More

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December 2018

Magnetic beads assay based on zip nucleic acid for electrochemical detection of factor V Leiden mutation.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Pharmacy, Analytical Chemistry Department, Ege University, Bornova, Izmir 35100, Turkey; Biotechnology Department, Graduate School of Natural and Applied Sciences, Ege University, Bornova, Izmir 35100, Turkey.

Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation among people. Development of reliable methods for the detection of SNP is crucial in aspects of molecular diagnosis and personalized medicine. In our study, a genomagnetic assay in combination with zip nucleic acid (ZNA) for electrochemical detection of SNP related to Factor V Leiden (FV Leiden) mutation. Read More

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December 2018

Preparation and drug release property of tanshinone IIA loaded chitosan-montmorillonite microspheres.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

In this study, a biocompatible chitosan/montmorillonite (CS/MMT) composite microsphere was developed as a carrier for loading and sustained-release of the hydrophobic drug of tanshinone IIA. Though the compatibility between hydrophobic drugs and hydrophilic matrix was fairly poor, tanshinone IIA was successfully loaded on the microsphere by the solvent exchange process during chitosan matrix dehydration. The microstructure of the resulting microspheres was characterized with several techniques, such as X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscope (SEM). Read More

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December 2018

Bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: the effect of NOD2/CARD15 mutations in a Tunisian population.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Immunogenetic Applied to Cells Therapy Research Unit, Immuno-Haematology and HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunis, Tunisia.

Bronchiolitis obliterans (BO) is a serious lung complication that can develop after allogenic stem cell transplantation. It has been suggested that single nucleotide polymorphisms (SNPs) that affect the NOD2/CARD15 gene impair its function and result in an uncontrolled innate immune response in the recipient, thereby leading to BO. One hundred eighty-one donor-recipient pairs were analyzed for the association between NOD2 gene variants (SNP8 [Arg702Trp], SNP12 [Gly908Arg], and SNP13 [Leu1007fsinsC]) and the occurrence of BO. Read More

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December 2018

Effects of proton pump inhibitors on severe haematotoxicity induced after first course of pemetrexed/carboplatin combination chemotherapy.

J Clin Pharm Ther 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Applied Therapeutics, Center for Education & Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo, Japan.

What Is Known And Objective: Pemetrexed/carboplatin combination chemotherapy has shown efficacy as a first-line treatment for advanced non-small-cell lung cancer. However, severe haematotoxicity is often observed during this combination chemotherapy. Some studies have suggested that concomitant drugs may be the risk factors for severe adverse events. Read More

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December 2018

Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform.

Swiss Med Wkly 2018 Dec 15;148:w14693. Epub 2018 Dec 15.

SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Facing multidrug resistant (MDR) bacterial pathogens is one of the most important challenges for our society. The spread of highly virulent and resistant pathogens can be described using molecular typing technologies; in particular, whole genome sequencing (WGS) data can be used for molecular typing purposes with high resolution. WGS data analysis can explain the spatiotemporal patterns of pathogen transmission. Read More

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December 2018

Effect of radiotherapy on the chemical composition of root dentin.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Background: The radiotherapy can directly affect the bond strength of the adhesive materials, interfering in the prognosis of restorative treatments, which may be caused by chemical changes in dentin structure.

Methods: Twenty inferior homologues premolars were distributed in 2 groups (in vitro study) (n = 10): nonirradiated and irradiated. The specimens were submitted to the analysis of phosphate (ν PO ;ν PO ;ν PO ), carbonate (ν CO ), amide I, CH , amide III, and amide I/III ratio by confocal Raman spectroscopy. Read More

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December 2018

Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Background: Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.

Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.

Results: In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Read More

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December 2018

Underestimated ecosystem carbon turnover time and sequestration under the steady state assumption: a perspective from long-term data assimilation.

Glob Chang Biol 2018 Dec 15. Epub 2018 Dec 15.

Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, China.

It is critical to accurately estimate carbon (C) turnover time as it dominates the uncertainty in ecosystem C sinks and their response to future climate change. In the absence of direct observations of ecosystem C losses, C turnover times are commonly estimated under the steady-state assumption (SSA), which has been applied across a large range of temporal and spatial scales including many at which the validity of the assumption is likely to be violated. However the errors associated with improperly applying SSA to estimate C turnover time and its covariance with climate as well as ecosystem C sequestrations have yet to be fully quantified. Read More

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December 2018

Effectiveness of a theory-based sun-safe randomised behavioural change trial among Australian adolescents.

Psychooncology 2018 Dec 15. Epub 2018 Dec 15.

Australian Institute for Suicide Research and Prevention, Griffith University, Mt Gravatt, Queensland.

Objective: Sun safety is crucial for preventing skin cancer. This study evaluated a school-based intervention based on the Theory of Planned Behaviour (TPB) which aimed to encourage sun-protective behaviour among adolescents.

Methods: Secondary school students (N=382; 61. Read More

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December 2018

Nurses' descriptions of person-centred care for older people in an acute medical ward - on the individual, team and organizational levels'.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

School of Nursing and Midwifery l College of Science, Health and Engineering, Latrobe University Melbourne, Victoria, Australia, 3086.

Aim And Objectives: To describe nurses' experiences of providing person-centred care (PCC) for older people on an acute medical ward.

Background: There is evidence that PCC for older people contributes to a higher quality care and increased satisfaction with care. However there is a shortness of studies providing concrete examples of what facilitates nurses providing PCC for older people in acute care. Read More

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December 2018

Feasibility study on direct fermentation of soybean meal by Bacillus stearothermophilus under non-sterile conditions.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212003, China.

Background: To evaluate the feasibility of high-temperature solid-state fermentation using soybean meal (SBM) during the non-sterile process, Bacillus stearothermophilus was employed to assess the nutritional quality and bioactivity of SBM after fermentation.

Results: The fermented SBM (FSBM) without autoclaving showed significant improvements in nutritional quality and bioactivity. The contents of peptides and, crude and soluble proteins increased by 131. Read More

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December 2018

Impacts of warming and water deficit on antioxidant responses in Panicum maximum Jacq.

Physiol Plant 2018 Dec 15. Epub 2018 Dec 15.

UNESP-Universidade Estadual Paulista, Faculdade de Ciências Agrarias e Veterinárias -FCAV, Departamento de Biologia Aplicada a Agropecuária (DBAA), 14884-900 Jaboticabal São Paulo, Brazil.

Agricultural activities are affected by many biotic and abiotic stresses associated with global climate change. Predicting the response of plants to abiotic stress under future climate scenarios requires an understanding of plant biochemical performance in simulated stress conditions. In this study the antioxidant response of Panicum maximum Jacq. Read More

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December 2018

Biosensor-Assisted Engineering of a High-Yield Pichia pastoris Cell-Free Protein Synthesis Platform.

Biotechnol Bioeng 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemical Engineering, Imperial College London, London, UK.

Cell-free protein synthesis (CFPS) has recently undergone a resurgence partly due to the proliferation of synthetic biology. The variety of hosts used for cell-free extract production has increased, which harnesses the diversity of cellular biosynthetic, protein folding, and posttranslational modification capabilities available. Here we describe a CFPS platform derived from Pichia pastoris, a popular recombinant protein expression host both in academia and the biopharmaceutical industry. Read More

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December 2018

From avatars to body swapping: The use of virtual reality for assessing and treating body-size distortion in individuals with anorexia.

J Clin Psychol 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.

In the last 30 years, virtual reality (VR) has offered innovative solutions for assessing and treating body representation disturbances in anorexia nervosa (AN). The most recent and innovative trend is the exploitation of the so-called VR-based body swapping illusion. The aim of this case study was to report the use of this VR protocol within a multidisciplinary treatment of AN. Read More

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December 2018

The Role of Real-World Evidence in UK Reimbursement: Case Study of Lenalidomide in Myelodysplastic Syndrome Deletion 5q.

Pharmacoecon Open 2018 Dec 14. Epub 2018 Dec 14.

King's College Hospital National Health Service Foundation Trust, London, UK.

Background: Uncertainty within cost-effectiveness analysis, often driven by lack of mature data from large clinical trials, plays a key role in decisions made by the National Institute for Health and Care Excellence (NICE), particularly for early access medicines and orphan drugs.

Objectives: In this case study, we used real-world evidence to address the uncertainty in the cost-effectiveness case for lenalidomide in transfusion-dependent low- and intermediate-1-risk myelodysplastic syndrome (MDS) deletion 5q [del(5q)], affecting a small but unique subpopulation with an orphan disease.

Methods: As part of a submission to NICE, we developed a cost-effectiveness model for lenalidomide, resulting in eventual recommendation. Read More

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December 2018

Effective mucosal live attenuated Salmonella vaccine by deleting phosphotransferase system component genes ptsI and crr.

J Microbiol 2018 Oct 2. Epub 2018 Oct 2.

Radiation Biotechnology Division, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.

Salmonella enterica is a major human pathogen that causes invasive non-typhoidal Salmonellosis (iNTS), resulting in significant morbidity and mortality. Although a number of pre-clinical and clinical studies have reported on the feasibility of developing a safe and effective vaccine against iNTS, there have been no licensed Salmonella vaccines available to protect against NTS strains. Vaccine formulations of highest priority for NTS are live attenuated vaccines, which can elicit effective induction of intestinal mucosal and intracellular bacteria-specific cell mediated immune responses. Read More

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October 2018

Polymorphisms in XPC gene and risk for prostate cancer.

Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Protein Engineering and Bio-active Molecules, National Institute of Applied Science and Technology - University of Carthage, Tunis, Tunisia.

Single nucleotide polymorphisms (SNP) in repair gene DNA such as XPC gene can reduce the DNA repair capacity (DRC). Reduced DRC induce genetic instability and may increase the susceptibility to prostate cancer (PC). We conducted a case-controls study to examine the relationship between XPC Lys939Gln and XPC-PAT polymorphisms and the risk for prostate cancer in Tunisian population. Read More

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December 2018

Comparable investigation of polyaniline behavior towards gaseous ammonia and toluene adsorption.

Environ Sci Pollut Res Int 2018 Dec 14. Epub 2018 Dec 14.

Chemical and Petrochemicals Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab Alexandria, Egypt.

With raising awareness of gaseous air pollutants and their harmful impact, adsorption is considered one of the most prominent techniques for gaseous emissions control. The usage of polyaniline as a gas adsorbent is an innovative idea. This work aims to compare the efficacy of synthesized polyaniline nanotubes (PANT) as a novel adsorbent towards inorganic gases (ammonia NH) and volatile organic compounds (toluene vapor). Read More

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December 2018

Microwave-Assisted Digestion Procedures Using Diluted Oxidant Mixture for Elemental Analysis of Crustaceans by MIP OES.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Group of Analytical Spectrometry Applied, Faculty of Chemistry, Federal University of Pará, Belém, Pará, 66075-110, Brazil.

The aim of this study was to evaluate three digestion procedures using a diluted oxidant mixture of nitric acid, hydrogen peroxide, and water for determination of Cu, Fe, K, Mg, Mn, and Zn in shrimp and crab samples from Northern Brazil by microwave-induced plasma optical emission spectrometry. The efficiency of the digestion procedure was evaluated by comparing the residual carbon content, residual acidity, and elemental concentrations obtained in the samples. Digestion procedure 2 (4 mL HNO + 4 mL HO + 4 mL HO) was chosen due the adequate residual carbon content (5. Read More

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December 2018

Endophyte composition and Cinchona alkaloid production abilities of Cinchona ledgeriana cultivated in Japan.

J Nat Med 2018 Dec 14. Epub 2018 Dec 14.

Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzo, 1, Gakuen-cho, Fukuyama, Hiroshima, 729-0292, Japan.

New eight endophytic filamentous fungi were isolated from the young stems of Cinchona ledgeriana (Rubiaceae) cultivated in Japan. They were classified into four genera based on phylogenetic analysis of the nucleotide sequences of the internal transcribed spacers (ITS1 and ITS2), including the 5.8S ribosomal DNA region. Read More

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December 2018

Positive influence of simvastatin used as adjuvant agent for cavity lining.

Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Pathology, Araraquara School of Dentistry, São Paulo State University (Unesp), Rua Humaitá, 1680, Araraquara, SP, 14801-903, Brazil.

Objectives: To assess the biological, antimicrobial, and mechanical effects of the treatment of deep dentin with simvastatin (SV) before application of a glass-ionomer cement (GIC).

Materials And Methods: Dentin discs were adapted to artificial pulp chambers and SV (2.5 or 1. Read More

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December 2018

Barriers and facilitators to understanding of ADHD in primary care: a mixed-method systematic review.

Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK.

Attention deficit hyperactivity disorder (ADHD) is a developmental disorder affecting up to 5% of children and adults and is underdiagnosed in many European countries. The process of access to care for this disorder is complex and variable across countries. In general, those affected, or their caregiver, will seek help through their primary care practitioners who are then often responsible for referral to other professionals for diagnosis and provision of treatment. Read More

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December 2018
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