958,038 results match your criteria Applied & Preventive Psychology[Journal]


Performance of revised STO(1M)-3G basis set for prediction of 5-fluorocytosine chemical shift.

Magn Reson Chem 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Chemistry, University of Opole, 48, Oleska Street, 46-052, Opole, Poland.

Nuclear shieldings and chemical shifts of 5-fluorocytosine (5FC) were predicted in the gas phase and DMSO solution modeled by polarizable continuum model (PCM) using B3LYP density functional and revised STO(1M)-3G basis set. For comparison, seven arbitrary selected basis sets including STO-3G, medium-size Pople- and larger dedicated Jensen-type ones were applied. The former basis sets were significantly smaller but the calculated structural parameters, harmonic vibrational frequencies were very accurate and close to those, obtained with larger, polarization-consistent ones. Read More

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http://dx.doi.org/10.1002/mrc.4879DOI Listing

Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease.

Eur Neurol 2019 Apr 23;81(1-2):13-18. Epub 2019 Apr 23.

Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan,

Background: Caudate nucleus atrophy is a well-known neuroimaging feature of Huntington's disease (HD). Some researchers have reported a decrease in the volume of the striatum on magnetic resonance images (MRIs) even in the presymptomatic stage of the disease. Despite the many neuroimaging studies on HD, the optimal method for measuring the caudate nucleus area on MRIs and the most effective cutoff values for diagnosing HD remain unclear. Read More

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http://dx.doi.org/10.1159/000499909DOI Listing

Effects of Botulinum Toxin A on Allodynia in Chronic Migraine: An Observational Open-Label Two-Year Study.

Eur Neurol 2019 Apr 23;81(1-2):37-46. Epub 2019 Apr 23.

Applied Neurophysiology and Pain, ANP- Unit, Bari Aldo Moro University, Bari, Italy.

Background: Onabotulinumtoxin A (OBT-A) is a treatment option for chronic migraine (CM), though the possible effect on central sensitization and allodynia is still unknown.

Aims: The present study aimed to evaluate (1) the long-term outcome of allodynia in a group of CM treated with OBT-A (2) if the presence and severity of allodynia could predict the long-term effect of OBT-A (3) if the improvement of allodynia, could contribute to the clinical efficacy of OBT-A.

Methods: This was an observational, open-label, cohort study conducted on 99 CM patients treated for 1 year and 44 patients treated for 2 years with periodic OBT-A 155-195 U injections. Read More

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http://dx.doi.org/10.1159/000499764DOI Listing

Carrier-induced antisymmetric-symmetric tendencies of spin stiffness in zigzag graphene nanoribbons.

J Phys Condens Matter 2019 Apr 23. Epub 2019 Apr 23.

Kanazawa University, Kanazawa, Ishikawa, JAPAN.

The generalized Bloch theorem was applied to calculate the spin stiffness and its tendencies when introducing the doping in zigzag graphene nanoribbons. To reach the intention, two different flat spin spiral formations were constructed by fixing the ferromagnetic and antiferromagnetic spin arrangements at the two different edges by applying a constraint scheme method. A spin stiffness was then calculated by means of a quadratic order function, which maps the total energy difference in the self-consistent calculations onto the Heisenberg Hamiltonian. Read More

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http://dx.doi.org/10.1088/1361-648X/ab1b9aDOI Listing

Impactibility Model for Population Health Management in High-Cost Elderly Heart Failure Patients: A Capture Method Using the ACG System.

Popul Health Manag 2019 Apr 23. Epub 2019 Apr 23.

6 College of Public Health, University of Georgia, Athens, Georgia.

The aim of the present study is to use the ACG (Adjusted Clinical Groups) System to create an impactibility model by identifying homogeneous clinical subgroups of patients with high risk of an adverse health outcome in a population of heart failure patients with complex health care needs (PCHCN). This method will allow policy makers to target and prioritize services for the highest risk PCHCN in the context of limited health care resources, by identifying relatively homogeneous groups of patients with similar comorbidities. Subjects classified in 2012 as PCHCN in a local health unit by the ACG System were linked with hospital discharge records in 2013. Read More

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http://dx.doi.org/10.1089/pop.2018.0190DOI Listing

DIY Automated Feeding and Motion Recording System for the Analysis of Fish Behavior.

SLAS Technol 2019 Apr 23:2472630319841412. Epub 2019 Apr 23.

2 Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany.

Fish species such as medaka or zebrafish are widely used as animal models to study physiology, disease development, and treatment efficacy. They are also used to study the rapidly growing field of behavior research, such as social interactions, anxiety, and the influence of environmental factors. Here we describe an automated experimental setup allowing the recording of general locomotor activity in combination with a food-on-demand system. Read More

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http://dx.doi.org/10.1177/2472630319841412DOI Listing

Using Surgeon Hand Motions to Predict Surgical Maneuvers.

Hum Factors 2019 Apr 23:18720819838901. Epub 2019 Apr 23.

University of Wisconsin-Madison, USA.

Objective: This study explores how common machine learning techniques can predict surgical maneuvers from a continuous video record of surgical benchtop simulations.

Background: Automatic computer vision recognition of surgical maneuvers (suturing, tying, and transition) could expedite video review and objective assessment of surgeries.

Method: We recorded hand movements of 37 clinicians performing simple and running subcuticular suturing benchtop simulations, and applied three machine learning techniques (decision trees, random forests, and hidden Markov models) to classify surgical maneuvers every 2 s (60 frames) of video. Read More

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http://dx.doi.org/10.1177/0018720819838901DOI Listing

A Systematic Narrative Review of the Evidence for Labeling of Natural Health Products and Dietary Supplements.

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

It is not clear what information is needed on labels of natural health products and dietary supplements to support informed consumer choice and use of these products. The purpose of this review was to explore if/how label information impacts consumer decision-making about food, over-the-counter drugs, and natural health products/dietary supplements and to make recommendations about how this evidence may be applied to natural health products/dietary supplements. A narrative analysis of a systematic review was performed. Read More

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http://dx.doi.org/10.1089/acm.2018.0533DOI Listing

Long non-coding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial-mesenchymal transition in pancreatic cancer.

Biochem Cell Biol 2019 Apr 23. Epub 2019 Apr 23.

Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases , No.295, Xichang Road , Kunming , China , 650032 ;

Background: This study focuses on lncRNA XIST, a lncRNA involved in multiple human cancers, and aims to investigate the functional significance of XIST and the molecular mechanism underlying the EMT in PC.

Methods: Clinical specimens from 25 patients and five human bladder cancer cell lines were analyzed for XIST, YAP and microRNA(miR)-34a by qRT-PCR and Immunohistochemistry (IHC). To investigate how XIST influences the cell proliferation, invasion, apoptosis in PC, we performed the CCK-8 assay, transwell assay and flow cytometry. Read More

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http://dx.doi.org/10.1139/bcb-2018-0274DOI Listing

Effect of Distal Esophageal Irritation on the Changes of Cystometry Parameters to Esophagus and Colon Distentions in Rats.

Authors:
Ezidin Kaddumi

Can J Physiol Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Al-Balqa' Applied University, 59303, Basic Medical Sciences , P. O. Box 206 , Al-Salt, Jordan , 19117.

The coexistence of different visceral pathologies on patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of theses pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation (DEI) on the urinary bladder interaction with distal colon distention (DCD), distal esophageal distention (DED), and electrical stimulation of abdominal branches of vagus nerve (abd-vagus). DEI significantly decreased the intercontraction time (ICT) via decreasing the voiding time (VT). Read More

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http://dx.doi.org/10.1139/cjpp-2019-0122DOI Listing

Crystal Orientation-Related Dynamic Tuning of the Lasing Spectra of CdS Nanobelts by Piezoelectric Polarization.

ACS Nano 2019 Apr 23. Epub 2019 Apr 23.

Realizing dynamic wavelength tunability could bring about tremendous impacts in laser technology, pressure nanosensing, and lab-on-a-chip devices. Here, we demonstrate an original strategy to operate the lasing mode-shift through the reversible length changes of a CdS nanobelt, which is determined by the direction of piezoelectric polarization. The relationships between the direction of applied strain, the lasing mode-shift and the tunable effective refractive index are elaborated in detail. Read More

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http://dx.doi.org/10.1021/acsnano.9b01735DOI Listing

[Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus].

Rev Alerg Mex 2019 Jan-Mar;66(1):38-43

Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Servicio de Alergia e Inmunología Clínica, Puebla, Puebla, México.

Background: The skin prick test is recognized as the gold standard for the specific diagnosis of allergy.

Objective: To determine the sensitivity and specificity of the epicutaneous patch test that has been modified for the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus.

Methods: An observational, interpretative, prolective, and transversal study. Read More

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http://dx.doi.org/10.29262/ram.v66i1.533DOI Listing

Structure and Bonding in [Sb@In8Sb12]3- and [Sb@In8Sb12]5.

Angew Chem Int Ed Engl 2019 Apr 23. Epub 2019 Apr 23.

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, State Key Laboratory of Rare Earth Resource Utilization, 5625 Renmin street , 130022, Changchun, CHINA.

We report the characterization of the compound [K(2.2.2)-crypt]4[In8Sb13], which proves to contain a 1:1 mixture of [Sb@In8Sb12]3- and [Sb@In8Sb12]5-. Read More

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http://dx.doi.org/10.1002/anie.201904109DOI Listing

Economic evaluations of onchocerciasis interventions: a systematic review and research needs.

Trop Med Int Health 2019 Apr 23. Epub 2019 Apr 23.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, UK.

Objective: To provide a systematic review of economic evaluations that have been conducted for onchocerciasis interventions, to summarise current key knowledge and to identify research gaps.

Method: A systematic review of the literature was conducted on the 8 of August 2018 using the PubMed (MEDLINE) and ISI Web of Science electronic databases. No date or language stipulations were applied to the searches. Read More

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http://dx.doi.org/10.1111/tmi.13241DOI Listing

HBcrAg to detect HBV reactivation in heart transplant recipients with past HBV infection: a pilot study.

Clin Transplant 2019 Apr 23:e13574. Epub 2019 Apr 23.

Internal Medicine, University of Campania "L. Vanvitelli", Naples, Italy.

Hepatitis B core-related antigen (HBcrAg) has been proposed as a new marker of HBV replication. We analyzed HBcrAg dynamics in 15 heart transplant recipients with active or prior HBV infection and correlated it with quantitative (QT)-HBsAg and HBV-DNA pre- and post-transplant. Serum HBcrAg was detected in HBsAg/HBV-DNA-positive subjects but not in recipients with past HBV infection. Read More

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http://dx.doi.org/10.1111/ctr.13574DOI Listing

A C-terminal CXCL8 peptide based on chemokine-glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation.

Immunology 2019 Apr 23. Epub 2019 Apr 23.

Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Medical School, Newcastle University and Newcastle NIHR Biomedical Research Centre, UK.

Leukocyte recruitment is critical during many acute and chronic inflammatory diseases. Chemokines are key mediators of leukocyte recruitment during the inflammatory response, by signaling through specific chemokine G-protein coupled receptors (GPCRs). In addition, chemokines interact with cell surface glycosaminoglycans (GAGs) to generate a chemotactic gradient. Read More

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http://dx.doi.org/10.1111/imm.13063DOI Listing
April 2019
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Simultaneous quantitative analysis of phosphocreatine, creatine and creatinine in plasma of children by HPLC-MS/MS method: Application to pharmacokinetic study in children with viral myocarditis.

Biomed Chromatogr 2019 Apr 23:e4558. Epub 2019 Apr 23.

Clinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China, Beijing, People's Republic of China.

A simple and rapid HPLC-MS/MS method was developed and validated for simultaneous measure of PCr and its metabolites creatine (Cr), creatinine (Cre) in children's plasma. 50 μL of plasma was prepared by protein precipitation with acetonitrile/water (1000 μL, 1:1, v/v) followed by separated on an Hypersil GOLD C18 column (35 C) with gradient mobile phase consisting of 2 mM ammonium acetate aqueous solution (pH 10) and methanol at a flow rate of 0.3 mL/min and analyzed by mass spectrometry in both positive (PCr) and negative (Cr and Cre) ion multiple reaction monitoring mode. Read More

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http://dx.doi.org/10.1002/bmc.4558DOI Listing

Look at me when I'm talking to you: Selective attention at a multisensory cocktail party can be decoded using stimulus reconstruction and alpha power modulations.

Eur J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

School of Engineering, Trinity Centre for Bioengineering and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.

Recent work using EEG has applied stimulus reconstruction techniques to identify the attended speaker in a cocktail party environment. The success of these approaches has been primarily based on the ability to detect cortical tracking of the acoustic envelope at the scalp level. However, most studies have ignored the effects of visual input, which is almost always present in naturalistic scenarios. Read More

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http://dx.doi.org/10.1111/ejn.14425DOI Listing

Short-term LPS induces Aortic Valve thickening in ApoE*3Leiden mice.

Eur J Clin Invest 2019 Apr 23:e13121. Epub 2019 Apr 23.

Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.

Background: Recently, it was shown that 12 weeks of lipopolysacharide (LPS) administration to non-atherosclerotic mice induced thickening of the aortic heart valve (AV). Whether such effects may also occur even earlier is unknown. As most patients with AV stenosis also have atherosclerosis, we studied the short-term effect of LPS on the AVs in an atherosclerotic mouse model. Read More

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http://dx.doi.org/10.1111/eci.13121DOI Listing

Progesterone Application to the Rat Forehead Produces Corneal Antinociception.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1706-1713

Center for Excellence in the Neurosciences, University of New England, Biddeford, Maine, United States.

Purpose: Ocular pain and discomfort are the most defining symptoms of dry eye disease. We determined the ability of topical progesterone to affect corneal sensitivity and brainstem processing of nociceptive inputs.

Methods: Progesterone or vehicle gel was applied to the shaved forehead in male Sprague Dawley rats. Read More

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http://dx.doi.org/10.1167/iovs.18-26049DOI Listing

Peptide barcoding for establishment of new types of genotype-phenotype linkages.

PLoS One 2019 23;14(4):e0215993. Epub 2019 Apr 23.

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, Japan.

Measuring binding properties of binders (e.g., antibodies) is essential for developing useful experimental reagents, diagnostics, and pharmaceuticals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215993PLOS

Diurnal variation of human tear meniscus volume measured with tear strip meniscometry self-examination.

PLoS One 2019 23;14(4):e0215922. Epub 2019 Apr 23.

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Purpose: Tear secretion is critical for maintenance of healthy ocular surface and vision. Most of normal subjects and dry eye patients feel worsening of ocular dryness in the afternoon, however, diurnal variation of tear meniscus volume has not been directly measured because there was no appropriate method. We used a simple, non-invasive technique, tear strip meniscometry (SM) by self-examination. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215922PLOS

Media portrayal of illness-related medical crowdfunding: A content analysis of newspaper articles in the United States and Canada.

PLoS One 2019 23;14(4):e0215805. Epub 2019 Apr 23.

Health Law Institute, Faculty of Law, University of Alberta, Edmonton, Alberta, Canada.

Background: Medical crowdfunding is a growing phenomenon, and newspapers are publishing on the topic. This research analyzed how illness-related crowdfunding and crowdfunding campaigns have recently been represented in newspapers that are popular in the United States and Canada.

Methods: A sample of 336 articles about medical crowdfunding published during the two year time period from October 7, 2015 to October 6, 2017 was produced using a Factiva search of the English language newspapers with the largest Canadian and United States readership. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215805PLOS

Stochastic block models: A comparison of variants and inference methods.

PLoS One 2019 23;14(4):e0215296. Epub 2019 Apr 23.

Production Systems and Logistic Systems, BIBA - Bremer Institut für Produktion und Logistik GmbH at the University of Bremen, Bremen, Bremen, Germany.

Finding communities in complex networks is a challenging task and one promising approach is the Stochastic Block Model (SBM). But the influences from various fields led to a diversity of variants and inference methods. Therefore, a comparison of the existing techniques and an independent analysis of their capabilities and weaknesses is needed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215296PLOS

Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network.

PLoS One 2019 23;14(4):e0214337. Epub 2019 Apr 23.

Center of Excellence in Bionanoscience Research, King Abdulaziz University, Jeddah, Saudi Arabia.

Obesity is connected to the activation of chronic inflammatory pathways in both adipocytes and macrophages located in adipose tissues. The nuclear factor (NF)-κB is a central molecule involved in inflammatory pathways linked to the pathology of different complex metabolic disorders. Investigating the gene expression data in the adipose tissue would potentially unravel disease relevant gene interactions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214337PLOS

An Adaptive Moment estimation method for online AUC maximization.

PLoS One 2019 23;14(4):e0215426. Epub 2019 Apr 23.

Beijing Institute of Applied Meteorology, Beijing, China.

Area Under the ROC Curve (AUC) is a widely used metric for measuring classification performance. It has important theoretical and academic values to develop AUC maximization algorithms. Traditional methods often apply batch learning algorithm to maximize AUC which is inefficient and unscalable for large-scale applications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215426PLOS

Synchronization dependent on spatial structures of a mesoscopic whole-brain network.

PLoS Comput Biol 2019 Apr 23;15(4):e1006978. Epub 2019 Apr 23.

Department of Applied Mathematics, University of Washington, Seattle, WA, USA.

Complex structural connectivity of the mammalian brain is believed to underlie the versatility of neural computations. Many previous studies have investigated properties of small subsystems or coarse connectivity among large brain regions that are often binarized and lack spatial information. Yet little is known about spatial embedding of the detailed whole-brain connectivity and its functional implications. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006978DOI Listing

Transcranial direct current stimulation treatment in chronic after-stroke dysphagia: A clinical case.

Psicothema 2019 May;31(2):179-183

Universidad de Almería, Instituto de Neurorehabilitación InPaula.

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that has shown positive effects in a variety of motor diseases including dysphagia. However, its clinical application and underlying microstructural effects are still being researched. We tested whether tDCS applied together with swallowing training could benefit a treatment-resistent patient with dysphagia after a stroke. Read More

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http://dx.doi.org/10.7334/psicothema2018.310DOI Listing

Preventing cognitive decline in chronic schizophrenia: Long-term effectiveness of integrated psychological therapy and emotional management training.

Psicothema 2019 May;31(2):114-120

Instituto de Investigación Sanitaria BIODONOSTIA, Universidad de País Vasco.

Background: Effective group psychological therapies in the chronic phases of schizophrenia are rare. This paper describes the results of testing a group therapy that includes integrated psychological therapy (IPT) together with an adaptation of emotional management therapy (EMT), delivered in a sample of outpatients with chronic schizophrenia.

Method: 42 patients received the psychological intervention during eight months and they were assessed at baseline, posttreatment and 1, 3, 6 and 12 months follow-up. Read More

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http://www.psicothema.com/psicothema.asp?id=4522
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http://dx.doi.org/10.7334/psicothema2018.254DOI Listing
May 2019
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Plasma miRNA-155 Levels Predict Atrial Fibrillation Recurrence after Cardioversion.

Heart Surg Forum 2019 Mar 11;22(2):E140-E148. Epub 2019 Mar 11.

Department of Laboratory, the First People's Hospital of Xianyang City, Xianyang, Shaanxi Province, China.

Background: MicroRNAs (miRNAs) are widely involved in the regulation of physiological processes, such as cell proliferation, differentiation, apoptosis, angiogenesis, and lipid metabolism. They might be associated with the pathological process of atrial fibrillation (AF). The purpose of our study is to investigate whether plasma miRNA-155 levels have a relationship with AF recurrence. Read More

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http://dx.doi.org/10.1532/hsf.2281DOI Listing

Endovascular Repair of Iliac Artery Aneurysms: A Single Center Experience in 10-Years.

Heart Surg Forum 2019 Feb 25;22(2):E088-E091. Epub 2019 Feb 25.

Cardiovascular Surgery Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.

Objectives: Isolated iliac artery aneurysms (IAAs) are rare, but nonetheless life-threatening when ruptured. The endovascular approach has taken over open repairs in time. The reported data is constituted of a retrospective series. Read More

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http://dx.doi.org/10.1532/hsf.2001DOI Listing
February 2019

Systematic Review of Validated Quality of Life and Swallow Outcomes after Transoral Robotic Surgery.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819844755. Epub 2019 Apr 23.

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, School of Medicine, Southern Illinois University, Springfield, Illinois, USA.

Objective: To systematically review the available evidence on the effects of transoral robotic surgery (TORS) on the posttreatment quality of life (QOL) and swallow function of patients with head and neck cancer.

Data Sources: PubMed and Ovid electronic databases were searched from inception to July 6, 2016. Specific database functions were applied to maximize the search. Read More

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http://dx.doi.org/10.1177/0194599819844755DOI Listing

Reduced Fading of Visual Afterimages after Transcranial Magnetic Stimulation over Early Visual Cortex.

J Cogn Neurosci 2019 Apr 23:1-12. Epub 2019 Apr 23.

Maastricht University.

In the complete absence of small transients in visual inputs (e.g., by experimentally stabilizing an image on the retina or in everyday life during intent staring), information perceived by the eyes will fade from the perceptual experience. Read More

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http://dx.doi.org/10.1162/jocn_a_01415DOI Listing

Characterizing trunk muscle activations during simulated low-speed rear impact collisions.

Traffic Inj Prev 2019 Apr 23:1-6. Epub 2019 Apr 23.

a Faculty of Applied Health Science, Department of Kinesiology , University of Waterloo , Waterloo , Ontario , Canada.

Objective: The purpose of this study was to evaluate the activation profiles of muscles surrounding the lumbar spine during unanticipated and braced simulated rear-end collisions.

Methods: Twenty-two low-speed sled tests were performed on 11 human volunteers ( V = 4 km/h). Each volunteer was exposed to one unanticipated impact and one braced impact. Read More

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http://dx.doi.org/10.1080/15389588.2019.1579317DOI Listing

Efficacy of Acetic Acid or Chitosan for Reducing the Prevalence of - and O157:H7-Contaminated Leafy Green Plants in Field Systems.

J Food Prot 2019 Apr 23:854-861. Epub 2019 Apr 23.

3 Department of Horticulture, University of Georgia, 2360 Rainwater Road, Tifton, Georgia 31793-5766, USA.

Outbreaks associated with fresh-cut leafy greens continue to occur despite efforts to implement horticultural practices that minimize introduction of enteric pathogens to the crop. The experimental trials in this study were designed to examine the efficacy of an acetic acid (AA)- and chitosan-based spray treatment, applied 1 day prior to harvest, for reducing the prevalence of O157:H7 (O157) and in field-grown leafy greens contaminated at levels detectable only through enrichment culture. Responses to the treatment solution were variable and depended on the type of leafy green (leafy lettuce, spinach, or cabbage), cultivar, pathogen, and AA concentration (0. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-347DOI Listing

Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents.

Org Lett 2019 Apr 23. Epub 2019 Apr 23.

Department of Bioengineering , Tokyo Institute of Technology , Box B-52, Nagatsuta-cho 4259 , Midori-ku, Yokohama 226-8501 , Japan.

Investigation of the copper-catalyzed coupling reaction of 2-pyridinesulfonates with Grignard reagents revealed that reactions with catalytic Cu(OTf) were completed in <40 min. The results differed from those of the previous CuI-catalyzed reactions of tosylates in the presence of additives (LiOMe and TMEDA) for 12-24 h. It was shown that the preferred coordination of the leaving group to the reagents accelerated the reaction. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b00976DOI Listing

Synthesis of 4-Oxoisoxazoline N-Oxides via Pd-Catalyzed Cyclization of Propargylic Alcohols with tert-Butyl Nitrite.

Org Lett 2019 Apr 23. Epub 2019 Apr 23.

State Key Laboratory of Applied Organic Chemistry , Lanzhou University , 222 South Tianshui Road , Lanzhou 730000 , P.R. China.

A cyclization of propargylic alcohols with tert-butyl nitrite at room temperature in air was achieved using Pd(OAc) as catalyst. The first reported 4-oxoisoxazoline N-oxides could be directly accessed from a range of multisubstituted propargylic alcohols in moderate to excellent yields under mild conditions. Density functional theory calculations indicated that the reaction proceeds through a palladium-catalyzed NO addition that efficiently generates a ketoxime radical, which eventually produces 4-oxoisoxazoline N-oxide. Read More

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http://pubs.acs.org/doi/10.1021/acs.orglett.9b00811
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http://dx.doi.org/10.1021/acs.orglett.9b00811DOI Listing
April 2019
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Prediction of orthosteric and allosteric regulations on cannabinoid receptors using supervised machine learning classifiers.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Designing highly selective compounds to protein subtypes, and developing allosteric modulators targeting them are critical considerations to both drug discovery and mechanism studies for cannabinoid receptors. It is challenging but in demand to have classifiers to identify active ligands from inactive or random compounds, and distinguish allosteric modulators from orthosteric ligands. In this study, supervised machine learning classifiers were built for two subtypes of cannabinoid receptors, CB1 and CB2. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00182DOI Listing

Crystal Structure and Photoluminescence Properties of an Incommensurate Phase in EuO- and PO-Doped CaSiO.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Department of Life Science and Applied Chemistry , Nagoya Institute of Technology , Nagoya 466-8555 , Japan.

We have for the first time clarified the incommensurately modulated crystal structure as well as the photoluminescence properties of Eu-activated CaSiO solid solution, the chemical formula of which is (CaEu□)(SiP)O, where □ denotes vacancies in Ca sites with the replacement of Si by P. The emission spectrum upon the 335 nm excitation showed a relatively broad band centered at ca. 490 nm and a full width at half-maximum of ca. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00408DOI Listing

Redox-Active Zeolitic Transition Metal Oxides Based on ε-Keggin Units for Selective Oxidation.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Engineering , Kanagawa University , Rokkakubashi, Kanagawa-ku, Yokohama-shi , Kanagawa 221-8686 , Japan.

The design and development of zeolitic transition metal oxides for selective oxidation are interesting due to the combination of the redox properties and microporosities. Redox-active zeolitic transition metal oxides based on ε-Keggin iron molybdates were synthesized. O can be activated by the materials via an electron-transfer-based process, and the materials can be oxidized even at room temperature. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00502DOI Listing

Luminescent Di- and Tetranuclear Gold Complexes of Bis(diphenylphosphinyl)-Functionalized Dipyrido-Annulated N-Heterocyclic Carbene.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Department of Applied Chemistry, Graduate School of Engineering , Hiroshima University , Higashi-Hiroshima 7398527 , Japan.

Phosphine-functionalized N-heterocyclic carbene (NHC) ligands are known to complex group 11 metal centers to form multinuclear complexes with photoluminescence properties. This study reports a structurally rigid ortho-substituted dipyrido-annulated NHC with T-shape coordination geometry and its di- and tetranuclear gold(I) complexes. The free ligand as well as all metal complexes are found luminescent at room temperature and phosphorescent at 77 K. Read More

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http://pubs.acs.org/doi/10.1021/acs.inorgchem.9b00514
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http://dx.doi.org/10.1021/acs.inorgchem.9b00514DOI Listing
April 2019
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A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Skin Center, Srinakharinwirot University, Bangkok, Thailand.

Background: Although there is a standard guideline for the treatment of acne, it is still a common skin disease, and suboptimal medication adherence is a major reason for treatment failure. Herbal extracts are an interesting alternative medicine because they consist of a variety of active ingredients. Moreover, herbal extracts may have improved therapeutic efficacy because of the combination of various herbs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12962
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http://dx.doi.org/10.1111/jocd.12962DOI Listing
April 2019
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Therapeutic patient education and self-management support for patients with psoriasis - a systematic review.

J Dtsch Dermatol Ges 2019 Apr 23. Epub 2019 Apr 23.

Division of Evidence-Based Medicine, Department of Dermatology, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Psoriasis is a chronic inflammatory skin condition. Patient education may be one option to improve adherence and coping. The aim of this systematic review is to identify studies evaluating educational interventions for psoriasis patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13840
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http://dx.doi.org/10.1111/ddg.13840DOI Listing
April 2019
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Benzodithiophene-fused Perylene Bisimides as Electron Acceptors for Non-fullerene Organic Solar Cells with High Open-Circuit Voltage.

Chemphyschem 2019 Apr 23. Epub 2019 Apr 23.

Institute of Chemistry, Chinese Academy of Sciences, CAS Key Laboratory of Organic Solids, Zhongguancun North First Street 2, 3#303, 100190, Beijing, CHINA.

Tandem-junction organic solar cells require solar cells with visible light photo-response as front cells, in which an open-circuit voltage (Voc) above 1.0 V is highly demanded. In this work, we are able to develop electron acceptors to fabricate non-fullerene organic solar cells (NFOSCs) with a very high Voc of 1. Read More

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http://dx.doi.org/10.1002/cphc.201900309DOI Listing

Reporting of Multi-Arm Parallel-Group Randomized Trials: Extension of the CONSORT 2010 Statement.

JAMA 2019 Apr;321(16):1610-1620

FHI 360, Durham, North Carolina.

Importance: The quality of reporting of randomized clinical trials is suboptimal. In an era in which the need for greater research transparency is paramount, inadequate reporting hinders assessment of the reliability and validity of trial findings. The Consolidated Standards of Reporting Trials (CONSORT) 2010 Statement was developed to improve the reporting of randomized clinical trials, but the primary focus was on parallel-group trials with 2 groups. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.3087DOI Listing

Photoelectron-photofragment coincidence studies of I using an electrospray ionization source and a linear accelerator.

Faraday Discuss 2019 Apr 23. Epub 2019 Apr 23.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Dr, La Jolla, Ca 92093-0340, USA.

Photoelectron-photofragment coincidence (PPC) spectroscopy is used to examine the dissociative photodetachment (DPD) of I3-. The high beam energy PPC spectrometer for complex anions couples an electrospray ionization source, a hexapole accumulation ion trap and a linear accelerator to produce fast beams of I3- (M = 381 amu) anions, the heaviest system studied to date. Following photodetachment, the photoelectron and up to three photofragments are recorded in coincidence yielding a kinematically complete picture of the DPD dynamics at beam energies of 11 keV and 21 keV. Read More

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http://dx.doi.org/10.1039/c8fd00216aDOI Listing

Intratumoral delivery of M-CSF by calcium crosslinked polymer micelles enhances cancer immunotherapy.

Biomater Sci 2019 Apr 23. Epub 2019 Apr 23.

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China. and International Center of Future Science, Jilin University, Changchun, Jilin, China and National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China and State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, China.

Immunotherapy has shown promising results in multiple malignancies. However, there are still significant challenges in cancer immunotherapy including the powerful immunosuppressive tumor microenvironment and adverse off-target side effects. Nanomaterials with defined physico-biochemical properties are versatile drug delivery platforms that may address these key technical challenges faced by cancer immunotherapy. Read More

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http://dx.doi.org/10.1039/c9bm00226jDOI Listing

A novel photochromic metal-organic framework with good anion and amine sensing.

Dalton Trans 2019 Apr 23. Epub 2019 Apr 23.

Institute of polyoxometalate Chemistry, Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024, PR China.

A novel metal-organic hybrid photochromic compound [Zn (CV) (L2)]·2H2O (1) (CV = N,N'-4,4'-bipyridiniodipropionate, H2L2 = isophthalic acid) has been synthesized solvothermally. Compound 1 features a two-dimensional (2D) framework structure, exhibiting photochromic properties under sunlight and UV irradiation with an obvious color change from colorless to dark blue. Meanwhile, the luminescence properties of 1 were investigated, and the results suggested that 1 has good properties of detecting dichromate ions. Read More

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http://dx.doi.org/10.1039/c8dt05032eDOI Listing

A Noninvasive, Economical, and Instant-Result Method to Diagnose and Monitor Type 2 Diabetes Using Pulse Wave: Case-Control Study.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e11959. Epub 2019 Apr 23.

Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of Traditional Chinese Medicine Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: We should pay more attention to the long-term monitoring and early warning of type 2 diabetes and its complications. The traditional blood glucose tests are traumatic and cannot effectively monitor the development of diabetic complications. The development of mobile health is changing rapidly. Read More

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http://dx.doi.org/10.2196/11959DOI Listing

Wearable-Based Mobile Health App in Gastric Cancer Patients for Postoperative Physical Activity Monitoring: Focus Group Study.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e11989. Epub 2019 Apr 23.

Department of Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.

Background: Surgical cancer patients often have deteriorated physical activity (PA), which in turn, contributes to poor outcomes and early recurrence of cancer. Mobile health (mHealth) platforms are progressively used for monitoring clinical conditions in medical subjects. Despite prevalent enthusiasm for the use of mHealth, limited studies have applied these platforms to surgical patients who are in much need of care because of acutely significant loss of physical function during the postoperative period. Read More

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http://dx.doi.org/10.2196/11989DOI Listing
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