1,072,075 results match your criteria Applied & Preventive Psychology[Journal]


Martius' flap repair for recurrent rectovaginal fistula - a video vignette.

Colorectal Dis 2020 Jul 14. Epub 2020 Jul 14.

King's College Hospital NHS Foundation Trust, London, UK.

Rectovaginal fistula (RVF) accounts for less than 5% of all perianal fistulas. Vagina delivery injuries are the most common cause, and this accounts for 60%-80% of cases. Martius' flap is often reserved for recurrent or complex RVF treatment with a success rate ranging from 60 to 100%. Read More

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http://dx.doi.org/10.1111/codi.15266DOI Listing

Association of Anesthesia Type with Postoperative Outcome and Complications in Patients Undergoing Revision Total Knee Arthroplasty.

J Knee Surg 2020 Jul 14. Epub 2020 Jul 14.

Department of Anesthesiology & Critical Care Medicine, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.

Revision total knee arthroplasty (TKA) is an increasingly common procedure and is effective in treating knee osteoarthritis, but it has higher complication rates than primary TKA. Anesthetic choice poses perioperative risk that has been extensively studied in primary TKA, showing favorable results for regional anesthesia compared with general anesthesia. The impact of anesthetic choice in revision TKAs is not well studied. Read More

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http://dx.doi.org/10.1055/s-0040-1713776DOI Listing

Image-enhanced endoscopy for gastric preneoplastic conditions and neoplastic lesions: a systematic review and meta-analysis.

Endoscopy 2020 Jul 14. Epub 2020 Jul 14.

Gastroenterology Department, Portuguese Oncology Institute of Porto, Porto, Portugal.

BACKGROUND : Image-enhanced endoscopy (IEE) improves the accuracy of endoscopic diagnosis. We aimed to assess the value of IEE for gastric preneoplastic conditions and neoplastic lesions. METHODS : Medline and Embase were searched until December 2018. Read More

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http://dx.doi.org/10.1055/a-1205-0570DOI Listing

Negative Association between Caloric Intake and Estimated Glomerular Filtration Rate in a Chinese Population: Mediation Models Involving Mitochondrial Function.

Gerontology 2020 Jul 14:1-8. Epub 2020 Jul 14.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, China,

Background: With the shortening of leukocyte telomere length (LTL) and decrease in the copy number of mitochondrial DNA, mitochondrial dysfunction and oxidative stress are considered important drivers of the aging process. Although previous experimental studies report that caloric intake is associated with age-related renal dysfunction through the changes in mitochondrial function, there are insufficient epidemiological data to establish this association.

Objective: We aimed to explore the association between caloric intake and renal function and to investigate whether mitochondrial DNA copy number (mtDNAcn) mediated this association by cross-sectional analysis. Read More

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http://dx.doi.org/10.1159/000508497DOI Listing

Moving beyond Ordinary Factor Analysis in Studies of Personality and Personality Disorder: A Computational Modeling Perspective.

Psychopathology 2020 Jul 14:1-11. Epub 2020 Jul 14.

Department of Psychology, The Ohio State University, Columbus, Ohio, USA,

Almost all forms of psychopathology, including personality disorders, are arrived at through complex interactions among neurobiological vulnerabilities and environmental risk factors across development. Yet despite increasing recognition of etiological complexity, psychopathology research is still dominated by searches for large main effects causes. This derives in part from reliance on traditional inferential methods, including ordinary factor analysis, regression, ANCOVA, and other techniques that use statistical partialing to isolate unique effects. Read More

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http://dx.doi.org/10.1159/000508539DOI Listing

Quality assurance of IMRT treatment plans for a 1.5 T MR-linac using a 2D ionization chamber array and a static solid phantom.

Phys Med Biol 2020 Jul 14. Epub 2020 Jul 14.

Department of Radiation Oncology, Eberhard Karls University Tübingen Faculty of Medicine, Tübingen, Baden-Württemberg, GERMANY.

MR-guided radiotherapy requires novel QA methods for IMRT treatment plans (TPs). Here, an optimized method for TPs for a 1.5 T MR-linac was developed and implemented clinically. Read More

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http://dx.doi.org/10.1088/1361-6560/aba5ecDOI Listing

self-organized three-dimensional model of the blood-brain barrier microvasculature.

Biomed Mater 2020 Jul 14. Epub 2020 Jul 14.

Department of Applied Chemistry, Osaka University, Faculty of Engineering, Suita, Osaka 565-0871, Osaka, JAPAN.

The blood-brain barrier (BBB) protects the human brain from external aggressions. Despite it great importance, very few in vitro models of the BBB reproducing its complex organization are yet available. Here we fabricated such a three-dimensional (3D) self-organized in vitro model of BBB microvasculature by means of collagen microfibers (CMF) and fibrin gel combination. Read More

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http://dx.doi.org/10.1088/1748-605X/aba5f1DOI Listing

Impact of Uniaxial Strain on Electronic and Transport Properties of Monolayer α-GeTe.

Nanotechnology 2020 Jul 14. Epub 2020 Jul 14.

Inner Mongolia University School of Physical Science and Technology, Hohhot, Inner Mongolia, CHINA.

Density functional theory calculations are performed to explore the electronic and transport properties of monolayer α-GeTe under uniaxial strains. It is found that monolayer α-GeTe has an indirect band gap of 1.75eV, and exhibits the worthwhile anisotropy along with high electron mobility. Read More

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http://dx.doi.org/10.1088/1361-6528/aba5b9DOI Listing

Dynamical regimes of kinematic vortices in the resistive state of a mesoscopic superconducting bridge.

J Phys Condens Matter 2020 Jul 14. Epub 2020 Jul 14.

Physics and Chemistry, UNESP, DFQ-Unesp, Av. Brasil, 56, centro, Ilha Solteria, São Paulo, 15385-000, BRAZIL.

In this work, we studied the dynamics of the kinematic vortices (kV) in a mesoscopic superconductor under the influence of external applied magnetic fields (H) and transport currents (J). A J(H) phase diagram is determined. We show that the vortex dynamics are profoundly affected by the presence of constrictions and by H. Read More

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http://dx.doi.org/10.1088/1361-648X/aba5a3DOI Listing

Adherence to social distancing and use of personal protective equipment and the risk of SARS-CoV-2 infection in a cohort of patients with multiple sclerosis.

Mult Scler Relat Disord 2020 Jul 3;45:102359. Epub 2020 Jul 3.

Department of Medicine of the Systems, Tor Vergata University, Rome, Italy; Multiple Sclerosis Clinical and Research Unit, Fondazione Policlinico di Tor Vergata, Rome, Italy.

Background Aiming to safeguard its population from COVID19 infection, Italian government provided specific advices, especially to fragile individuals such those affected by Multiple Sclerosis (MS), to respect social distancing, to arrange remote work and to use personal protective equipment (PPE). The aim of this study is to investigate real adherence to these measures among MS patients and to evaluate its impact on exposure to infection. Methods MS patients followed at the MS center of Tor Vergata University hospital, Rome, Italy were asked to complete an anonymous 35-items web-survey exploring demographics, residency, employment, social distancing habits, use of PPE, MS features and COVID19 infection data, including self-reported information about contacts with SARS-CoV-2 positive/presumed positive persons. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102359DOI Listing

Simple, fast and robust LC-MS/MS method for the simultaneous quantification of canagliflozin, dapagliflozin and empagliflozin in human plasma and urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 26;1152:122257. Epub 2020 Jun 26.

University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, Netherlands; University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmaceutical Analysis, Groningen, Netherlands.

Sodium-glucose cotransporter 2 -inhibitors (SGLT2i) are oral glucose-lowering drugs that have also demonstrated cardioprotective and renoprotective effects. SGLT2i play an increasingly important role in the treatment of type 2 diabetes. Here we report a simple and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of three SGLT2i (canagliflozin, dapagliflozin and empagliflozin) in human plasma, serum and urine with a runtime of 1 min. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122257DOI Listing

A comprehensive computational study and simulation of innovative zwitterionic materials for enhanced poly (vinylidene fluoride) membrane hydrophilicity.

J Mol Graph Model 2020 Jul 8;100:107656. Epub 2020 Jul 8.

Department of Chemical and Biological Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, Saskatchewan, S7N 5A9, Canada. Electronic address:

The goal of this study is to design a novel zwitterionic (ZW)-poly (vinylidene fluoride) (PVDF) membrane with high hydrophilicity potential using the pair interaction energy decomposition analysis (PIEDA) integrated with fragment molecular orbital (FMO) method. In addition, the differential hydration and efficiency of salt rejection of the novel zwitterion and original PVDF were investigated using molecular dynamics simulation (MDS). Within this study computational methods were applied to investigate the performance of zwitterionic moieties derived from three different anionic groups in the ZW head, specifically, carboxylate, sulfonate, and phosphate. Read More

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http://dx.doi.org/10.1016/j.jmgm.2020.107656DOI Listing

Distinguishing paracetamol formulations: Comparison of potentiometric "Electronic Tongue" with established analytical techniques.

J Pharm Biomed Anal 2020 Jul 6;188:113457. Epub 2020 Jul 6.

ITMO University, St Petersburg, Russia; Institute of Chemistry, Saint Petersburg State University, St Petersburg, Russia. Electronic address:

Fast and inexpensive analytical tools for identification of the origin of pharmaceutical formulations are important to ensure consumers safety. This study explores the potential of potentiometric multisensor systems ("electronic tongues") in this type of application. 72 paracetamol samples purchased in different countries and produced by various companies were studied via infrared spectroscopy (IR), near infrared spectroscopy (NIR), nuclear magnetic resonance spectroscopy (NMR) and multisensor system (ET). Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113457DOI Listing

Roasting-induced changes in cocoa beans with respect to the mood pyramid.

Food Chem 2020 Jul 4;332:127467. Epub 2020 Jul 4.

Food Structure & Function Research Group (FSF), Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

The mood pyramid of cocoa, which was previously proposed as a new concept, consists of four levels (flavan-3-ols, methylxanthines, minor compounds and orosensory properties). Roasting is a crucial process for flavor development in cocoa but is likely to have a negative impact on the phytochemicals. We investigated the effect of roasting time (10-50 min) and temperature (110-160 °C) on the potential mood-enhancing compounds corresponding to the distinct mood pyramid levels. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127467DOI Listing

Electrochemical behavior of reduced graphene oxide/cyclodextrins sensors for ultrasensitive detection of imidacloprid in brown rice.

Food Chem 2020 Jul 6;333:127495. Epub 2020 Jul 6.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:

Various pesticides employed in modern agriculture result in large amounts of pesticide residues in agricultural production, greatly threatening human health. Herein, we report a facile approach to fabricate a reduced graphene oxide/cyclodextrin modified glassy carbon electrode (rGO/CD/GCE) for the sensitive electrochemical sensing of imidacloprid (IDP). Three different modified electrodes using CDs (α-, β-, γ-CD) were fabricated, and their electrochemical performance was further studied. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127495DOI Listing

B-vitamin supplementation ameliorates anxiety- and depression-like behavior induced by gestational urban PM exposure through suppressing neuroinflammation in mice offspring.

Environ Pollut 2020 Jul 7;266(Pt 2):115146. Epub 2020 Jul 7.

Neurologic Disorders and Regeneration Repair Lab of Shandong Higher Education, Department of Histology and Embryology, Weifang Medical University, Weifang, China. Electronic address:

PM exposure is an emerging environmental concern and severe health insult closely related to psychological conditions such as anxiety and depression in adolescence. Adolescence is a critical period for neural system development characterized by continuous brain maturation, especially in the prefrontal cortex. The etiology of these adolescent conditions may derive from fetal origin, probably attributed to the adverse effects induced by intrauterine environmental exposure. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115146DOI Listing

Nematodes as bioindicators of polluted sediments using metabarcoding and microscopic taxonomy.

Environ Int 2020 Jul 11;143:105922. Epub 2020 Jul 11.

Department of Animal Ecology, Bielefeld University, Konsequenz 45, 33615 Bielefeld, Germany. Electronic address:

The use of bioindicator species is a widely applied approach to evaluate ecological conditions, and several indices have been designed for this purpose. To assess the impact of pollution, especially in sediments, a pollution-sensitive index based on nematodes, one of the most abundant and species-rich groups of metazoa, was developed. The NemaSPEAR[%] index in its original form relies on the morphological inspection of nematode species. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105922DOI Listing

Social and spatial distribution of soil lead concentrations in the City of Santa Ana, California: Implications for health inequities.

Sci Total Environ 2020 Jul 6;743:140764. Epub 2020 Jul 6.

Program in Public Health, University of California, Irvine, CA 92697, USA; Center for Occupational and Environmental Health, University of California, Irvine 92617, CA, USA. Electronic address:

Background: Lead (Pb) exposure is a problem that disproportionately impacts low-income communities and communities of color. We applied a community-based participatory research approach to assess the distribution of soil Pb concentrations and related social vulnerabilities across Census tracts in Santa Ana, CA.

Methods: Soil Pb samples (n = 1528) were collected by the ¡Plo-NO! Santa Ana! Lead-Free Santa Ana! partnership in 2018 across Santa Ana, CA, at a high spatial resolution and measured using XRF analysis. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140764DOI Listing

Land use regression modelling of PM spatial variations in different seasons in urban areas.

Sci Total Environ 2020 Jul 6;743:140744. Epub 2020 Jul 6.

CAS Key Laboratory of Forest Ecology and Management, Institute of Applied Ecology, Chinese Academy of Sciences, No. 72, Wenhua Road, Shenyang 110016, China; College of Resources and Environment, University of Chinese Academy of Sciences, No. 19, Yuquan Road, Beijing 100049, China.

As one of the principal components of haze, fine particulate matter (PM) has potential negative health effects, causing widespread concern. Identification of the pollutant spatial variation is a prerequisite of understanding ambient air pollution exposure and further improving air quality. Seven urban built-up areas in Liaoning central urban agglomeration (LCUA) were used for land use regression (LUR) modelling of PM concentrations using small amounts of spatially aggregated data and to assess the model's seasonal consistency. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140744DOI Listing

Particulate plutonium released from the Fukushima Daiichi meltdowns.

Sci Total Environ 2020 Jul 8;743:140539. Epub 2020 Jul 8.

Department of Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. Electronic address:

Traces of Pu have been detected in material released from the Fukushima Daiichi Nuclear Power Plant (FDNPP) in March of 2011; however, to date the physical and chemical form of the Pu have remained unknown. Here we report the discovery of particulate Pu associated with cesium-rich microparticles (CsMPs) that formed in and were released from the reactors during the FDNPP meltdowns. The Cs-pollucite-based CsMP contained discrete U(IV)O nanoparticles, <~10 nm, one of which is enriched in Pu adjacent to fragments of Zr-cladding. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140539DOI Listing

Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase.

Bioorg Chem 2020 Jun 30;102:104065. Epub 2020 Jun 30.

College of Pharmacy, College (Institute) of Integrative Medicine, Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China; Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China. Electronic address:

Pulmonary fibrosis is a progressive, irreversible, and fatal fibrotic lung disease with a high mortality and morbidity, and commonly nonresponsive to conventional therapy. Inula japonica Thunb. is a traditional Chinese medicine, known as "Xuan Fu Hua" in Chinese, and has been widely applied to relieve cough and dyspnea and eliminate retained phlegm with a long history. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104065DOI Listing

Hierarchical fibrous guiding cues at different scales influence linear neurite extension.

Acta Biomater 2020 Jul 11. Epub 2020 Jul 11.

DWI-Leibniz Institute for Interactive Materials, Aachen, 52074, Germany; ITMC-Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, 52074, Germany; ITMC-Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen, 52074, Germany.

Surface topographies at micro- and nanoscales can influence different cellular behavior, such as their growth rate and directionality. While different techniques have been established to fabricate 2-dimensional flat substrates with nano- and microscale topographies, most of them are prone to high costs and long preparation times. The 2. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.014DOI Listing

In-situ synthesis of FeS nanocrystals decorated on N, S-codoped carbon nanotubes as anode material for high-performance lithium-ion batteries.

J Colloid Interface Sci 2020 Jun 26;579:699-706. Epub 2020 Jun 26.

School of Electrical and Power Engineering, China University of Mining and Technology, Xuzhou 221116, China. Electronic address:

FeS has emerged as an attractive anode material for lithium-ion batteries (LIBs) due to its outstanding features such as low cost, high theoretical capacity, as well as environmental benignity. However, the rapid capacity fading derived from the tremendous volume change during the charging/discharging process hinders its practical application. Nanostructure engineering and the combination with carbonaceous material are essential to address this issue. Read More

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http://dx.doi.org/10.1016/j.jcis.2020.06.087DOI Listing

Breast lesion characterization using Quantitative Ultrasound (QUS) and derivative texture methods.

Transl Oncol 2020 Jul 11;13(10):100827. Epub 2020 Jul 11.

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada; Departments of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Purpose: Accurate and timely diagnosis of breast cancer is extremely important because of its high incidence and high morbidity. Early diagnosis of breast cancer through screening can improve overall prognosis. Currently, biopsy remains as the gold standard for tumor pathological confirmation. Read More

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http://dx.doi.org/10.1016/j.tranon.2020.100827DOI Listing

Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach.

Eur J Med Chem 2020 Jun 24;201:112461. Epub 2020 Jun 24.

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

To develop inhibitors blocking VEGFR2 and the Raf/MEK/ERK mitogen-activated protein kinase signaling pathway new compounds based on sorafenib were designed, synthesized and biologically evaluated. Using de novo design method, a library of new ligands was generated and expanded. Considering in silico binding affinity towards VEGFR2, synthetic feasibility, and drug-likeness property, some of the designed ligands were selected for synthesis and screening for their in vitro antiproliferative activities against two cancer cell lines (HT-29 and A549). Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112461DOI Listing

Dry Powder Inhaler Aerosol Deposition in a Model of Tracheobronchial Airways: Validating CFD Predictions with In Vitro Data.

Int J Pharm 2020 Jul 11:119599. Epub 2020 Jul 11.

Biotechnology Research Center, Student Research Committee, and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Effective drug delivery into the lungs plays an important role in management of pulmonary diseases that affect millions all around the world. The main objective of this investigation is to study airflow structure, as well as transport and deposition of micron-size particles at different inhalation flow rates in a realistic model of human tracheobronchial airways. The airway model was developed based on computed tomography (CT) images of a healthy 48-years-old female, which includes extrathoracic, trachea, and bronchial airways up to fourth generations. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119599DOI Listing

3D High Spatial Resolution Visualisation and Quantification of Interconnectivity in Polymer Films.

Int J Pharm 2020 Jul 11:119622. Epub 2020 Jul 11.

Department of Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.

A porous network acts as transport paths for drugs through films for controlled drug release. The interconnectivity of the network strongly influences the transport properties. It is therefore important to quantify the interconnectivity and correlate it to transport properties for control and design of new films. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119622DOI Listing

Design of Condition-based Maintenance Framework for Process Operations Management in Pharmaceutical Continuous Manufacturing.

Int J Pharm 2020 Jul 11:119621. Epub 2020 Jul 11.

Davidson School of Chemical Engineering, Purdue University, 480 Stadium Mall Drive, West Lafayette, IN, USA.

Continuous manufacturing, an emerging technology in the pharmaceutical industry, has the potential to increase the efficiency, and agility of pharmaceutical manufacturing processes. To realize these potential benefits of continuous operations, effectively managing materials, equipment, analyzers, and data is vital. Developments for continuous pharmaceutical manufacturing have led to novel technologies and methods for processing material, designing and configuring individual equipment and process analyzers, as well as implementing strategies for active process control. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119621DOI Listing

Estradiol modulated colorectal cancer stem cells bioactivity and interaction with endothelial cells.

Life Sci 2020 Jul 11:118078. Epub 2020 Jul 11.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

This study aimed to evaluate the modulatory role of sex-related hormone estradiol on cancer stem cells with the origin of colorectal adenocarcinoma in vitro. Cancer stem cells were incubated with 100 nM estradiol for 48 h. The cell survival rate was analyzed using the MTT assay. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118078DOI Listing

A rapid and sensitive lateral flow immunoassay (LFIA) test for the on-site detection of banana bract mosaic virus in banana plants.

J Virol Methods 2020 Jul 11:113929. Epub 2020 Jul 11.

Molecular Virology Lab, ICAR-National Research Centre for Banana, Thogamalai Road, Thayanur Post, Tiruchirappalli, 620102, TN, India.

Banana bract mosaic virus (BBrMV) is a serious pathogen threatening the cultivation of banana and plantain worldwide. This study reports the development of a practical, rapid, sensitive, specific and user-friendly lateral flow immunoassay (LFIA) test for the on-site detection of BBrMV. The BBrMV coat protein (CP) was expressed in Escherichia coli and purified and used to immunize rabbits to produce a polyclonal antiserum (anti-BBrMVCP). Read More

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http://dx.doi.org/10.1016/j.jviromet.2020.113929DOI Listing

A custom-made functionalization method to control the biological identity of nanomaterials.

Nanomedicine 2020 Jul 11:102268. Epub 2020 Jul 11.

Group of Nanomedicina-IDIVAL University of Cantabria, Herrera Oria s/n, 39011, Santander, Spain. Electronic address:

Here we propose a one-step strategy to endow nanomaterials with a custom-designed bio-identity. This study designs a universal `nanomaterial binding domain´ that can be genetically attached to any protein ensuring precise and spontaneous protein orientation. We demonstrate how, despite the simplicity of the method, the bioconjugation achieved is: (i) highly efficient, even in the presence of competing proteins, (ii) is stable at extreme physiological conditions (pH ranges 5. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102268DOI Listing

Habitual sleep duration affects recovery from acute sleep deprivation: a modeling study.

J Theor Biol 2020 Jul 11:110401. Epub 2020 Jul 11.

Departments of Mathematics and Anesthesiology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Adult humans exhibit high interindividual variation in habitual sleep durations, with short sleepers typically sleeping less than 6 hours per night and long sleepers typically sleeping more than 9 hours per night. Analysis of the time course of homeostatic sleep drive in habitual short and long sleepers has not identified differences between these groups, leading to the hypothesis that habitual short sleep results from increased tolerance to high levels of homeostatic sleep drive. Using a physiologically-based mathematical model of the sleep-wake regulatory network, we investigate responses to acute sleep deprivation in simulated populations of habitual long, regular and short sleepers that differ in daily levels of homeostatic sleep drive. Read More

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http://dx.doi.org/10.1016/j.jtbi.2020.110401DOI Listing

Temperature alters reproduction and maternal provisioning in a fish ectoparasite.

Int J Parasitol 2020 Jul 11. Epub 2020 Jul 11.

Centre for Sustainable Tropical Fisheries and Aquaculture and the College of Science and Engineering, James Cook University, Townsville, Queensland 4811, Australia; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand. Electronic address:

This study quantified the effects of temperature on reproduction and maternal provisioning of the ectoparasite, Neobenedenia girellae (Platyhelminthes: Monogenea), a species known to cause detrimental impacts to aquaculture fishes in tropical and subtropical environments worldwide. At 20 and 25 °C, parasites exhibited relatively slower production of larger eggs that were energy-dense. In contrast, parasites at 30 °C attained sexual maturity faster, were reproductively active over a shorter period, grew to a smaller size and laid smaller, less energy-rich eggs at a faster rate. Read More

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http://dx.doi.org/10.1016/j.ijpara.2020.03.017DOI Listing

Biofilm Matrixome: Extracellular Components in Structured Microbial Communities.

Trends Microbiol 2020 Aug 21;28(8):668-681. Epub 2020 Apr 21.

Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine University of Zurich, Zurich, Switzerland. Electronic address:

Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix is composed of a complex array of extracellular polymeric substances (EPS) that contribute to the unique attributes of biofilm lifestyle and virulence. This ensemble of chemically and functionally diverse biomolecules is termed the 'matrixome'. Read More

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http://dx.doi.org/10.1016/j.tim.2020.03.016DOI Listing

Determining the Tractional Forces on Vitreoretinal Interface Using Computer Simulation Model in Abusive Head Trauma.

Am J Ophthalmol 2020 Jul 11. Epub 2020 Jul 11.

Ophthalmology & Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE.

Background: Abusive head trauma (AHT) is the leading cause of infant death and long-term morbidity from injury. The ocular consequences of AHT are controversial, and the pathophysiology of retinal research findings is still not clearly understood. It has been postulated that vitreoretinal traction plays a major role in the retinal findings. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.020DOI Listing

The Most Common Functional Groups in Bioactive Molecules and How Their Popularity has Evolved Over Time.

J Med Chem 2020 Jul 14. Epub 2020 Jul 14.

The concept of functional groups (FGs) - sets of connected atoms that can determine the intrinsic reactivity of the parent molecule and in part are responsible for the overall properties of the molecule form a foundation within modern medicinal chemistry. In this article we analyze the occurrence of various FGs in molecules described in the medicinal chemistry literature in the last 40 years and show how their development and utilization over time has varied. The popularity of various FGs has not evolved randomly but instead clear patterns of use are evident. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.0c00754DOI Listing

Assessing Air Quality and Public Health Benefits of New York City's Climate Action Plans.

Environ Sci Technol 2020 Jul 14. Epub 2020 Jul 14.

Strategies that reduce greenhouse gas (GHG) emissions may also provide significant public health benefits and their estimation can help prioritize the case for climate change mitigation policies. In 2014, New York City (NYC) committed to reduce GHG emissions by 80% by 2050 (80x50). In this analysis we quantified the air quality-related public health benefits of the policies outlined in the 80x50 strategy, compared sector-specific (buildings, energy, transportation) policy impacts, and assessed variations in benefits across NYC neighborhoods. Read More

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http://dx.doi.org/10.1021/acs.est.0c00694DOI Listing

Uncoupling sodium channel dimers rescues the phenotype of a pain-linked Nav1.7 mutation.

Br J Pharmacol 2020 Jul 14. Epub 2020 Jul 14.

Institute of Physiology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

Background & Purpose: The voltage-gated sodium channel Nav1.7 is essential for adequate perception of painful stimuli. Mutations in the encoding gene, SCN9A, cause various pain syndromes in human patients. Read More

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http://dx.doi.org/10.1111/bph.15196DOI Listing

Association Between Changes in Timing of Spring Onset and Asthma Hospitalization in Maryland.

JAMA Netw Open 2020 Jul 1;3(7):e207551. Epub 2020 Jul 1.

Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park.

Importance: Ongoing climate change is affecting the health of communities across the globe. While direct consequences, including morbidity and mortality tied to increases in the frequency of extreme weather events, have received significant attention, indirect health effects, particularly those associated with climate change-driven disruptions in ecosystems, are less understood.

Objective: To investigate how ongoing changes in the timing of spring onset related to climate change are associated with rates of asthma hospitalization in Maryland. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.7551DOI Listing

Effects of occlusal scheme on All-on-Four abutments, screws and prostheses: A three-dimensional finite element study.

J Oral Implantol 2020 Jul 14. Epub 2020 Jul 14.

Akdeniz University Faculty of Dentistry, Department of Prosthodontics, Antalya, Türkiye.

An ideal occlusal scheme plays an important role in a good prognosis of All-on-Four applications, as it does for other implant therapies, due to the potential impact of occlusal loads on implant prosthetic components. The aim of the present three-dimensional (3D) finite element analysis (FEA) study was to investigate the stresses on abutments, screws and prostheses that are generated by occlusal loads via different occlusal schemes in the All-on-Four concept. Three-dimensional models of the maxilla, mandible, implants, implant substructures and prostheses were designed according to the All-on-Four concept. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-19-00334DOI Listing

Artificial Intelligence Neuropathologist for Glioma Classification using Deep Learning on Hematoxylin and Eosin Stained Slide images and Molecular Markers.

Neuro Oncol 2020 Jul 14. Epub 2020 Jul 14.

Glioma Surgery Division, Neurologic Surgery Department, Huashan Hospital, Fudan University, Shanghai, China.

Background: Pathological diagnosis of glioma subtypes is essential for treatment planning and prognosis. Standard histological diagnosis of glioma is based on postoperative hematoxylin and eosin stained slides by neuropathologists. With advancing artificial intelligence (AI), the aim of this study was to determine whether deep learning can be applied to glioma classification. Read More

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http://dx.doi.org/10.1093/neuonc/noaa163DOI Listing

The effect of school smoke-free policies on smoking stigmatization: A European comparison study among adolescents.

PLoS One 2020 14;15(7):e0235772. Epub 2020 Jul 14.

Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium.

The increasing denormalization of smoking by tobacco control policies and a normative smoke-free climate may shift power towards adolescent non-smokers. It is unclear, however, how common stigmatization of smokers is among adolescents or how stigmatization relates to the denormalization of smoking in their school and social environment. This paper aims to measure (1) whether stigmatization among European adolescents varies according to smoking status and socioeconomic position (SES), and (2) whether stigmatization is greater in school environments in which smoking is denormalized (i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235772PLOS

Soil solution in Swiss forest stands: A 20 year's time series.

PLoS One 2020 14;15(7):e0227530. Epub 2020 Jul 14.

Federal Office for the Environment, Berne, Switzerland.

Soil solution chemistry is influenced by atmospheric deposition of air pollutants, exchange processes with the soil matrix and soil-rhizosphere-plant interactions. In this study we present the results of the long-term Intercantonal Forest Observation Program in Switzerland with soil solution measurements since 1998 on a current total of 47 plots. The forest sites comprise two major forest types of Switzerland including a wide range of ecological gradients such as different nitrogen (N) deposition and soil conditions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227530PLOS

Food and nutritional security of semi-arid farm families benefiting from rainwater collection equipment in Brazil.

PLoS One 2020 14;15(7):e0234974. Epub 2020 Jul 14.

Graduate Program in Collective Health, Faculty of Medicine, University of Campinas (Unicamp), Campinas, São Paulo, Brazil.

The objective of this study was to identify and describe the experience of family farmers and their respective families after using the Boardwalk Cistern rainwater collection system and consequent impacts on nutrition profile and food security. This is a qualitative-quantitative study conducted in two municipalities in the semi-arid region of the state of Alagoas, northeastern Brazil. A structured questionnaire was applied to collect information on demographic and socioeconomic status and household access to food, based on the Brazilian Food Insecurity Scale of 29 family farmers' households. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234974PLOS

TET repression and increased DNMT activity synergistically induce aberrant DNA methylation.

J Clin Invest 2020 Jul 14. Epub 2020 Jul 14.

Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.

Chronic inflammation is deeply involved in various human disorders, such as cancer, neurodegenerative disorders, and metabolic disorders. Induction of epigenetic alterations, especially aberrant DNA methylation, is one of the major mechanisms, but how it is induced is still unclear. Here, we found that expression of TET genes, methylation erasers, was down-regulated in inflamed mouse and human tissues, and that this was caused by up-regulation of TET-targeting miRNAs, such as MIR20A, MIR26B, and MIR29C, likely due to activation of NF-kB signaling, downstream of IL-1b and TNF-a. Read More

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http://dx.doi.org/10.1172/JCI124070DOI Listing

Deformational Plagiocephaly and Reduced Cervical Range of Motion: A Pediatric Case Series in a Chiropractic Clinic.

Altern Ther Health Med 2020 Jul 15. Epub 2020 Jul 15.

Context: Deformational plagiocephaly, a non-synostotic asymmetry of the occipital bone, is a frequent occurrence in infants, with a peak incidence of 19.7% at 4 months of age. One aetiology is hypothesized to be due to restriction in normal cervical spine motion. Read More

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Decompensation in Critical Care: Early Prediction of Acute Heart Failure Onset.

JMIR Med Inform 2020 Jul 7. Epub 2020 Jul 7.

Department of Systems and Industrial Engineering, Department of Biomedical Engineering, The University of Arizona, Tucson, US.

Background: Heart failure is a leading cause of mortality and morbidity worldwide. Acute heart failure, broadly defined as rapid onset of new or worsening signs and symptoms of heart failure, often requires hospitalization and admission to the intensive care unit (ICU). This acute condition is highly heterogeneous and less well-understood as compared to chronic heart failure. Read More

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http://dx.doi.org/10.2196/19892DOI Listing

Implementation of a standardized initial assessment for demand management in outpatient emergency care in Germany: an early qualitative process evaluation.

JMIR Form Res 2020 May 14. Epub 2020 May 14.

Department of General Practice and Health Services Research, University Hospital Heidelberg, Im Neuenheimer Feld 130.3, Heidelberg, DE.

Background: Inadequate assessment of the severity and urgency of a medical problem is one of the factors contributing to unnecessary emergency department (ED) visits. The implementation of a software-based instrument for standardized initial assessment (SmED) aims to support healthcare professionals and steer patients to the right healthcare provider. This study aimed to explore the implementation process of SmED from a user perspective. Read More

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http://dx.doi.org/10.2196/18456DOI Listing

Model-based Algorithms for Detecting Peripheral Artery Disease Using Administrative Data From an Electronic Health Record Data System.

JMIR Med Inform 2020 Jun 28. Epub 2020 Jun 28.

Duke University School of Medicine, Department of Medicine, DUMC Box 3330, Durham, US.

Background: Peripheral artery disease (PAD) affects 8-10 million Americans, who face significantly elevated risks of both mortality and major limb events (such as amputation). Unfortunately, PAD is relatively under-diagnosed, under-treated, and under-researched, leading to wide variations in treatment patterns and outcomes. Efforts to improve PAD care and outcomes have been hampered by persistent difficulties identifying PAD patients for clinical and investigatory purposes. Read More

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http://dx.doi.org/10.2196/18542DOI Listing

Cross-border malaria: contributing to elimination through a standardized solution for case surveillance, data sharing and interpretation.

JMIR Public Health Surveill 2020 Jun 1. Epub 2020 Jun 1.

ESPACE-DEV, French Research Institute for Sustainable Development (IRD), University of Montpellier, University of La Réunion, University of French Guiana, University of French Antilles, Cayenne, French Guiana, and Montpellier, FR.

Background: Cross-border malaria is a significant obstacle to achieving malaria control and elimination worldwide.

Objective: This study aimed to build a cross-border surveillance system that can provide comparable and qualified data available to all parties involved in malaria control between French Guiana and Brazil.

Methods: Data reconciliation rules based on expert knowledge were defined and applied to the heterogeneous data provided by the existing malaria surveillance systems of both countries. Read More

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http://dx.doi.org/10.2196/15409DOI Listing
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