941,366 results match your criteria Applied & Preventive Psychology[Journal]


Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach.

J Nutr Biochem 2018 Dec 12;66:52-62. Epub 2018 Dec 12.

Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil. Electronic address:

GPR120 and GPR40 were recently reported as omega-3 (ω3) receptors with anti-inflammatory properties. Physical exercise could increase the expression of these receptors in the liver, improving hepatic metabolism in obesity and type 2 diabetes. Our aim was to investigate GPR120/40 in the liver of lean and obese mice after acute or chronic physical exercise, with or without the supplementation of ω3 rich flaxseed oil (FS), as well as assess the impact of exercise and FS on insulin signaling and inflammation. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2018.12.003DOI Listing
December 2018

Probing deoxysugar conformational preference: A comprehensive computational study investigating the effects of deoxygenation.

Carbohydr Res 2018 Dec 12;475:17-26. Epub 2018 Dec 12.

Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA. Electronic address:

Deoxysugars are intrinsic components in a number of antibiotics, antimicrobials, and therapeutic agents that often dictate receptor binding, improve efficacy, and provide a diverse toolbox in modifying glycoconjugate function due to an extensive number of unique isomers and inherent conformational flexibility. Hence, this work provides a comprehensive examination of the conformational effects associated with deoxygenation of the pyranose ring. Both the location and degree of deoxygenation were evaluated by interrogating the energetic landscape for a number of mono- and dideoxyhexopyranose derivatives using DFT methods (M05-2X/cc-pVTZ(-f)). Read More

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http://dx.doi.org/10.1016/j.carres.2018.12.003DOI Listing
December 2018

Purification and biochemical characterization of a novel copper, zinc superoxide dismutase from liver of camel (Camelus dromedarius): An antioxidant enzyme with unique properties.

Bioorg Chem 2019 Feb 11;86:428-436. Epub 2019 Feb 11.

Chemistry Education, Kazim Karabekir Education Faculty, Atatürk University, 25240 Erzurum, Turkey.

A novel copper, zinc superoxide dismutase (CuZnSOD) was purified to homogeneity from the liver of an animal well adapted to the stressful living conditions of the desert, the camel (Camelus dromedarius). The biochemical properties of camel liver CuZnSOD were examined. The purified enzyme had a native molecular weight of 28 kDa, as judged by gel filtration chromatography, and showed a single band at 27 kDa on SDS-PAGE, indicating that it is a monomeric protein. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.024DOI Listing
February 2019

Factors Influencing Colon and Rectal Surgery Residency Program Selection.

J Surg Res 2019 Feb 13;238:137-143. Epub 2019 Feb 13.

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Little information exists to help colon and rectal surgery residency programs determine which factors applicants find important when selecting a training program. Our aim was to identify factors applicants find pertinent in the selection of their desired colon and rectal surgery residency program.

Methods: After the 2016 and 2017 National Resident Matching Program (The Match), a 58-question anonymous web-based survey was sent to all trainees who applied to our colon and rectal surgery residency program to determine factors applicants find important in selecting colon and rectal surgery residency training programs. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.042DOI Listing
February 2019

Development of a scenario-based stormwater management planning support system for reducing combined sewer overflows (CSOs).

J Environ Manage 2019 Feb 13;236:571-580. Epub 2019 Feb 13.

U.S. Environmental Protection Agency, Office of Research and Development, National Risk Management Research Laboratory, Water Systems Division, Water Resources Recovery Branch, Cincinnati, OH, USA. Electronic address:

Using combined sewer systems to handle excess stormwater runoff is common in older urban areas. Combined sewer overflow (CSO) events occur when hydraulic capacity is exceeded, and untreated wastewater discharges to surface waters. As urban population density increases, and more demand is placed on infrastructure, CSO events happen more often and cause serious environmental problems and public-health risks. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.12.089DOI Listing
February 2019

Facile thermal activation of non-reactive cryptocrystalline magnesite and its application on the treatment of acid mine drainage.

J Environ Manage 2019 Feb 13;236:499-509. Epub 2019 Feb 13.

Council for Scientific and Industrial Research (CSIR), Built Environment (BE), Hydraulic Infrastructure Engineering (HIE), P.O Box 395, Pretoria 0001, South Africa.

In this study, the authors report a facile thermal activation of non-reactive cryptocrystalline magnesite and explore its application on the treatment of acid mine drainage (AMD). The primary aim was to optimize the calcination-water interface reactive conditions. Parameters evaluated include calcination temperature, calcination time, AMD-calcination temperature interface, and AMD-calcination duration interface. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.030DOI Listing
February 2019

Degradation of methyl orange on Fe/Ag nanoparticles immobilized on polyacrylonitrile nanofibers using EDTA chelating agents.

J Environ Manage 2019 Feb 13;236:481-489. Epub 2019 Feb 13.

Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028 Johannesburg, South Africa.

Bimetallic nanoparticles are effective for the removal of organic pollutants from environmental water samples through catalytic degradation reactions. Hence, this work reports on the preparation of Fe/Ag bimetallic nanoparticles immobilized on electrospun polyacrylonitrile nanofibers (PAN NFs) pre-functionalized with EDTA and ethylenediamine (EDA) chelating agents. Characterization techniques included attenuated total reflectance coupled to Fourier transform infrared spectrometer (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.023DOI Listing
February 2019

Electron transfer interpretation of the biofilm-coated anode of a microbial fuel cell and the cathode modification effects on its power.

Bioelectrochemistry 2019 Feb 8;127:94-103. Epub 2019 Feb 8.

Department of Environmental Engineering, Daejeon University, Daejeon 34520, Republic of Korea. Electronic address:

Biofilm-coated electrodes and outer cell membrane-mimicked electrodes were examined to verify an extracellular electron transfer mechanism using Marcus theory for a donor-acceptor electron transfer. Redox couple-bound membrane electrodes were prepared by impregnating redox coenzymes into Nafion films on carbon cloth electrodes. The electron transfer was believed to occur sequentially from acetate to nicotinamide adenine dinucleotide (NAD), c-type cytochrome, flavin mononucleotide (FMN) (or riboflavin (RBF)) and the anode substrate. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2019.02.004DOI Listing
February 2019

Identification and characterization of unknown degradation impurities in beclomethasone dipropionate cream formulation using HPLC, ESI-MS and NMR.

J Pharm Biomed Anal 2019 Feb 10;167:123-131. Epub 2019 Feb 10.

Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung City, Taiwan; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan. Electronic address:

The present study focuses on identifying the degradation profile and pathways of unknown impurities from beclomethasone dipropionate (BDP) topical cream formulation reported under accelerated stability conditions. Six degradation impurities were observed during the accelerated stability testing of BDP topical cream formulation, and these thermally labile degradation impurities were primarily identified using a simple, effective and mass compatible isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection method. The degradation impurities found in this sample were of very low concentration levels, thus the concentration of these impurities in the sample was enriched by mimicking the thermal degradation conditions to structurally elucidate the unknown impurities. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.013DOI Listing
February 2019

A tri-functionalised PtSnO-based electrocatalyst for hydrogen generation via ammonia decomposition under native pH conditions.

J Colloid Interface Sci 2019 Jan 22;542:451-459. Epub 2019 Jan 22.

Applied Technology Promotion Center of Chongqing Education Committee For Chemical Pollution Prevention and Control, Chongqing Industry Polytechnic College, Chongqing 401120, PR China.

Hydrogen is one of the most clean energy carriers because water is only the product of its combustion. The electrolysis of ammonia is expected to offer an attractive alternative to water electrolysis for the production of hydrogen because of the lower thermodynamic energy. However, the synthesis and utilization of high-performance Pt electrocatalysts have encountered challenges related to instability and hydroxyl ion sensitivity. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.085DOI Listing
January 2019

Adsorption of cerium (III) by HKUST-1 metal-organic framework from aqueous solution.

J Colloid Interface Sci 2019 Jan 31;542:421-428. Epub 2019 Jan 31.

Fushun Research Institute of Petroleum and Petrochemicals, SINOPEC, Fushun 113001, China.

Cerium is an important rare earth element (REE), which can be used for many high-tech applications. From the industrial and environmental viewpoints, it is imperative to recover Ce ions from aqueous solution. Herein, HKUST-1 metal-organic framework (MOF) was applied for adsorption and recovery of Ce from aqueous solution. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.117DOI Listing
January 2019

A rare case of transient left ventricular apical ballooning syndrome following living donor liver transplantation: A case report and literature review.

Int J Surg Case Rep 2019 Feb 10;55:218-222. Epub 2019 Feb 10.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Introduction: Transient Left Ventricular Apical Balloon Syndrome (LV-ABS) is an unknown acute dysfunction of the left ventricle, which develops under emotional or physical stress events like the major surgical postoperative period.

Presentation Of Case: A 68-year-old woman diagnosed with hepatitis C cirrhosis was admitted for living donor liver transplantation (LDLT). No evidence for underlying cardiac or pulmonary disease was found. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193006
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http://dx.doi.org/10.1016/j.ijscr.2019.02.002DOI Listing
February 2019

TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells.

Mol Ther Nucleic Acids 2019 Jan 18;14:567-582. Epub 2019 Jan 18.

Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China. Electronic address:

Chemoresistance remains a great obstacle in effective lung adenocarcinoma (LUAD) treatment. Previously, we verified the role of microRNA-200b (miR-200b) in the formation of docetaxel (DTX)-resistant LUAD cells. This study aims to investigate the mechanism underlying the low level of miR-200b in DTX-resistant LUAD cells. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.005DOI Listing
January 2019

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Eur J Med Chem 2019 Feb 8;167:161-186. Epub 2019 Feb 8.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address:

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able to simultaneously hit cholinesterases, cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX) enzymes. Among the synthesized compounds, triazoles 5b and 5d, and thiosemicarbazide hybrid 6e emerged as promising new hits, being able to effectively inhibit human butyrylcholinesterase (hBChE), COX-2 and 15-LOX enzymes with a higher inhibitory potency than the reference inhibitors tacrine (for hBChE inhibition), celecoxib (for COX-2 inhibition) and both NDGA and Zileuton (for 15-LOX inhibition). Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.012DOI Listing
February 2019

Hydrothermal synthesis of p-CN/f-BiOBr composites with highly efficient degradation of methylene blue and tetracycline.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 7;214:103-110. Epub 2019 Feb 7.

Department of Applied Chemistry, Xi'an University of Technology, Xi'an 710048, China; State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China, Xi'an University of Technology, Xi'an 710048, China. Electronic address:

Construction of heterojunctions with band-suitable different semiconductors has been demonstrated to be an efficient approach to enhance the separation of photoinduced electrons and holes. In this paper, highly efficient heterojuction photocatalysts consisted of porous-CN (p-CN) and flowerlike-BiOBr (f-BiOBr) were successfully synthesized via a deposition-hydrothermal method. The SEM and HRTEM images indicated that BiOBr were successfully deposited on the surface of p-CN and the layered p-CN/f-BiOBr heterojunctions were formed between p-CN and f-BiOBr. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.008DOI Listing
February 2019

Polymeric prodrug microspheres with tumor intracellular microenvironment bioreducible degradation, pH-triggered "off-on" fluorescence and drug release for precise imaging-guided diagnosis and chemotherapy.

Colloids Surf B Biointerfaces 2019 Feb 4;177:313-320. Epub 2019 Feb 4.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address:

Theranostic nanoplatforms have been recognized for imaging-guided diagnosis and chemotherapy of cancer by integrating imaging function into the drug delivery systems (DDSs). Here, a facile approach was developed for the fabrication of polymeric prodrug microspheres by introducing pH sensitive "off-on" fluorochrome Rhodamine 6G into bioreducible cleavable bisulfide crosslinked PEGylated poly(glycidyl methacrylate) (PEG-PGMA) microspheres, followed with chemical conjugation of doxorubicin (DOX) via an acid-labile hydrazone linkage. High drug content of 25. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.002DOI Listing
February 2019

Zirconium based metal-organic framework in-situ assisted hydrothermal pretreatment and enzymatic hydrolysis of Platanus X acerifolia exfoliating bark for bioethanol production.

Bioresour Technol 2019 Feb 8;280:213-221. Epub 2019 Feb 8.

Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province, Yancheng Institute of Technology, Yancheng 224051, China. Electronic address:

Metal-organic framework (MOF) assisted hydrothermal pretreatment and co-catalysis strategy based on UiO-66 MOF is developed for the first time. The Planetree exfoliating bark was pretreated with or without UiO-66 assisted hydrothermal method at a temperature ranging from 160 to 240 °C for 1-3 h residence. With the rise of pretreatment severity, the total reducing sugar (TRS) was increased till reached maximum, 180 mg g, in the presence of UiO-66. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.041DOI Listing
February 2019

Syngas production from biomass using Fe-based oxygen carrier: Optimization.

Bioresour Technol 2019 Feb 2;280:183-187. Epub 2019 Feb 2.

Collaborative Innovation Center of Biomass Energy, Henan Agricultural University, Henan Province, Zhengzhou 450002, China.

Chemical looping gasification is a promising technology to convert biomass into syngas with low adverse effects by heat loss and production dilution. This study utilized 60% loading FeO/AlO oxygen carrier (OC) for gasification tests on four biomass samples: rice straw, corn stalk, peanut shell and wheat straw under OC/biomass (OC/B) ratio of 1.0, steam/biomass (S/B) ratio of 2. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.012DOI Listing
February 2019

Performance and stability of a dynamically controlled EBPR anaerobic/aerobic granular sludge reactor.

Bioresour Technol 2019 Feb 10;280:151-157. Epub 2019 Feb 10.

Research Group BioGEM, Bio-Chemical Green Engineering & Materials, Faculty of Applied Engineering, University of Antwerp, Salesianenlaan 90, 2660 Antwerp, Belgium. Electronic address:

Treatment of rapidly varying wastewaters in anaerobic/aerobic aerobic granular sludge (AGS) systems remains problematic. This study investigated AGS formation and the impact of varying COD and phosphorus concentrations on an enhanced biological phosphorus removal (EBPR) AGS SBR with a conductivity based anaerobic and OUR based aerobic dynamically controlled step. Phase 1 investigated the development of AGS. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.052DOI Listing
February 2019

Effects of reduced glutathione on the quality of rooster sperm during cryopreservation.

Theriogenology 2019 Jan 15;128:149-155. Epub 2019 Jan 15.

Department of Animal Science, Faculty of Agriculture and Natural Resources, University of Arak, Arak, Iran.

The purpose of this study was to investigate the beneficial effects of reduced glutathione (GSH) for cryopreservation of rooster semen. In experiment 1, semen samples were collected from 15 roosters and diluted in the Lake extender that contained various concentrations of GSH as follows: Lake without GSH (control, GSH 0), Lake containing 0.5 mM (GSH 0. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.01.016DOI Listing
January 2019

Regulatory T lymphocytes are associated with increased nasopharyngeal colonization in children.

Int J Pediatr Otorhinolaryngol 2019 Feb 5;120:51-57. Epub 2019 Feb 5.

Office of Senior DVC and Provost, Swinburne University of Technology, Melbourne, Australia. Electronic address:

Objectives: Regulatory T lymphocytes (T) have been linked to survival of commensal bacteria at mucosal sites, but their presence and role in chronic otitis media (COM) and their response to otopathogens has not been evaluated previously. We investigated the association between T lymphocytes and otopathogens in COM prone and non-COM prone children.

Methods: Forty children, 2-7 years of age, scheduled for adenoidectomy were enrolled into COM (n = 20) or non-COM (n = 20) groups. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.011DOI Listing
February 2019

Predictors of epilepsy presentation in unruptured brain arteriovenous malformations: a quantitative evaluation of location and radiomics features on T2 weighted imaging.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Departments of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To explore predictors of epilepsy presentation in unruptured bAVMs with quantitative evaluation of location and radiomics features on T2 weighted imaging.

Methods: This retrospective study identified 117 patients with unruptured bAVMs. Cases were randomly split into training (n=90) and test dataset (n=27). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.229DOI Listing
February 2019

Acute and sub-acute toxicity of the aqueous extract from the stem bark of Tetrapleura tetrapteura Taub. (Fabaceae) in mice and rats.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

H.E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research (P.C.M.D.), International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

Ethnopharmacological Relevance: Tetrapleura tetrapteura Taub. is a leguminous multipurpose tree (Fabaceae) indigenous to tropical Africa. Fruits, seeds and stem bark infusions or decoctions of Tetrapleura tetrapteura Taub. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.026DOI Listing
February 2019

Ascl1 Regulates Electric Field-Induced Neuronal Differentiation through PI3K/Akt Pathway.

Neuroscience 2019 Feb 13. Epub 2019 Feb 13.

Department of Histology & Embryology, College of Basic Medical Sciences, Jilin University, Changchun 130021, PR China. Electronic address:

Directing differentiation of neural stem/progenitor cells (NSCs/NPCs) to produce functional neurons is one of the greatest challenging in regenerative medicine. Our previous paper has confirmed that electrical stimulation has a high efficiency of triggering neuronal differentiation by using isolated filum terminale (FT) derived NPCs. To further clarify the intrinsic molecular mechanisms, protein-protein interaction (PPI) network analysis was applied to pinpoints novel hubs in electric field (EF)-induced neuronal differentiation. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.004DOI Listing
February 2019

Natural and synthetic nanopores directing osteogenic differentiation of human stem cells.

Nanomedicine 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell Biology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany; Molecular Neurobiology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany; Bielefeld Institute for Nanoscience (BINAS), Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany. Electronic address:

Bone regeneration is a highly orchestrated process crucial for endogenous healing procedures after accidents, infections or tumor therapy. Changes in surface nanotopography are known to directly affect the formation of osteogenic cell types, although no direct linkage to the endogenous nanotopography of bone was described so far. Here we show the presence of pores of 31. Read More

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http://dx.doi.org/10.1016/j.nano.2019.01.018DOI Listing
February 2019

SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy; Infertility Service, San Salvatore Hospital, L'Aquila 67100, L'Aquila, Italy. Electronic address:

Methylglyoxal (MG), a highly reactive dicarbonyl derived from metabolic processes, is the most powerful precursor of advanced glycation end products (AGEs). Glycative stress has been recently associated with ovarian dysfunctions in aging and PCOS syndrome. We have investigated the role of the NAD-dependent Class III deacetylase SIRT1 in the adaptive response to MG in mouse oocytes and ovary. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.011DOI Listing
February 2019

Velogenic newcastle disease virus tissue tropism and pathogenesis of infection in chickens by application of in situ PCR, immunoperoxase staining and HE staining.

Microb Pathog 2019 Feb 13. Epub 2019 Feb 13.

Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Limited deep studies are available in the field of early stages of pathogenesis of Newcastle disease virus (NDV) infection and tissue tropism of NDV. In this study, 24 specific pathogen free (SPF) chickens of white leghorn breed were infected with Newcastle disease (ND) by intranasal administration of 10⁵ 50% EID50/0.1 mL of velogenic NDV (vNDV). Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.017DOI Listing
February 2019

Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

Expanding the promoter toolbox of Bacillus megaterium.

J Biotechnol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry, Campus B2.2, 66123, Saarland University, Saarbrücken, Germany. Electronic address:

Over the past decades, Bacillus megaterium has gained significant interest in the biotechnological industry due to its high capacity for protein production. Although many proteins have been expressed efficiently using the optimized xylose inducible system so far, there is a considerable demand for novel promoters with varying activities, particularly for the adjustment of protein levels in multi-enzyme cascades. Genome-wide microarray analyses of the industrially important B. Read More

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http://dx.doi.org/10.1016/j.jbiotec.2019.01.018DOI Listing
February 2019

Experts' Consensus on Intraoperative Radiotherapy for Pancreatic Cancer.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

National Cancer Center, China and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address:

Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.01.038DOI Listing
February 2019

Do theta oscillations explain the somatosensory change detection mechanism?

Biol Psychol 2019 Feb 13. Epub 2019 Feb 13.

Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China; Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, Beijing, China.

Recent research has indicated that the mismatch negativity (MMN) is elicited in response to a discernible small change of a somatosensory stimulus applied on the hand. However, the neural mechanism for detecting small change of somatosensory stimulus remains unknown. In the present study, we developed a novel pressure stimulation device using air jet applied on the index finger pad, and determined the just noticeable differences (JNDs) of pressure discrimination for each subject. Read More

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http://dx.doi.org/10.1016/j.biopsycho.2019.02.001DOI Listing
February 2019

Evaluation of an "all-in-one" seven-day WGS solution in the investigation of a Staphylococcus aureus outbreak in a neonatal Intensive Care Unit.

J Hosp Infect 2019 Feb 13. Epub 2019 Feb 13.

AP-HP, Hôpitaux Universitaires Paris Sud, Hôpital Antoine Béclère, Service de Bactériologie-Hygiène, Clamart, France; EA4043, Bactéries Pathogènes et Santé, Faculté de Pharmacie, Université Paris Sud, Chatenay-Malabry, France; Institute of Integrative Biology of the Cell, CNRS, CEA, Univ. Paris Sud, Paris Saclay University, Gif sur Yvette, France. Electronic address:

Background: Meticillin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA) are responsible for outbreaks in intensive care units. MSSA infections have the same morbidity and mortality rate as MRSA infections but are less often studied. Whole genome sequencing (WGS) is increasingly used for outbreak monitoring but still requires specific installation and trained personnel to obtain and analyse the data. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.01.029DOI Listing
February 2019

Development of a sandwich enzyme-linked immunosorbent assay for the quantification of ponatinib in serum.

Anal Biochem 2019 Feb 13. Epub 2019 Feb 13.

Applied Life Science Department, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda, Kumamoto, 860-0082, Japan.

The tyrosine kinase inhibitor ponatinib is extensively metabolized in the body, and consequently the development of specific immunoassays for pharmacokinetic studies and therapeutic drug monitoring of ponatinib is challenging. If two antibodies simultaneously recognize the entire structure of ponatinib, they could be utilized to establish an ultra-specific sandwich immunoassay for ponatinib, free of any interference from ponatinib metabolites. In this study, we created two types of anti-ponatinib polyclonal antibodies that recognize two different ponatinib epitopes, and sandwiched almost all structural components of ponatinib in these two antibodies in order to develop an enzyme-linked immunosorbent assay (ELISA) technique not affected by any ponatinib metabolites. Read More

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http://dx.doi.org/10.1016/j.ab.2019.02.010DOI Listing
February 2019
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Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City, Taiwan. Electronic address:

Neutrophil extracellular traps (NETs) are net-like chromatin fibers that can trap and kill microorganisms. Although several anti-inflammatory effects of intravenous anesthetics have been reported, it has not been investigated whether intravenous anesthetics influence NET formation.

Aims: To compare the effects of four intravenous anesthetics (propofol, thiamylal sodium, midazolam, and ketamine) on phorbol myristate acetate (PMA)-induced NET formation and analyze the associated signaling pathways. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.030DOI Listing
February 2019

The importance of non-technical performance for teams managing postpartum haemorrhage: video review of 99 obstetric teams.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

School of Applied Psychology, University of Applied Sciences and Arts Northwestern Switzerland, Switzerland.

Objective: Little is known about how teams' non-technical performance influences clinical performance in obstetric emergencies like postpartum haemorrhage.

Design: Video review - observational study.

Setting: A university hospital (5,000 deliveries) and a regional hospital (2,000 deliveries) in Denmark. Read More

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http://dx.doi.org/10.1111/1471-0528.15655DOI Listing
February 2019

Automated Pectoral Muscle Identification on MLO-view Mammograms: Comparison of Deep Neural Network to Conventional Computer Vision.

Med Phys 2019 Feb 16. Epub 2019 Feb 16.

School of Data and Computer Science, Sun Yat-Sen University, Guangzhou, 510275, P.R. China.

Objectives: To develop a fully automated deep learning approach for identification of the pectoral muscle on mediolateral oblique (MLO) view mammograms and evaluate its performance in comparison to our previously developed texture-field orientation (TFO) method using conventional image feature analysis. Pectoral muscle segmentation is an important step for automated image analyses such as breast density or parenchymal pattern classification, lesion detection, and multi-view correlation.

Materials And Methods: Institutional Review Board (IRB) approval was obtained before data collection. Read More

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http://dx.doi.org/10.1002/mp.13451DOI Listing
February 2019
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Radiation dose in nuclear medicine: the hybrid imaging.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Dipartimento di Biomedicina e Prevenzione, Università di Roma Tor Vergata, Rome, Italy.

Hybrid imaging procedures such as single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT) showed a rapid diffusion in recent years because of their high sensitivity, specificity, and accuracy, due to a more accurate localization and definition of scintigraphic findings. However, hybrid systems inevitably lead to an increase in patient radiation exposure because of the added CT component. Effective doses due to the radiopharmaceuticals can be estimated by multiplying the administered activities by the effective dose coefficients, while for the CT component the dose-length product can be multiplied by a conversion coefficient k. Read More

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http://dx.doi.org/10.1007/s11547-019-00989-yDOI Listing
February 2019

New advances in MRI diagnosis of degenerative osteoarthropathy of the peripheral joints.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio 1, 67100, L'Aquila, Italy.

Degenerative osteoarthropathy is one of the leading causes of the pain and disability from musculoskeletal disease in the adult population. Magnetic resonance imaging (MRI) allows optimal visualization of all tissues involved in degenerative osteoarthritis disease process, mainly the articular cartilage. In addition to qualitative and semiquantitative morphologic assessment, several MRI-based advanced techniques have been developed to allow characterization and quantification of the biochemical cartilage composition. Read More

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http://dx.doi.org/10.1007/s11547-019-01003-1DOI Listing
February 2019

A voltammetric hybridization assay for microRNA-21 using carboxylated graphene oxide decorated with gold-platinum bimetallic nanoparticles.

Mikrochim Acta 2019 Feb 15;186(3):185. Epub 2019 Feb 15.

Department of Biochemistry, Panjab University, Chandigarh, 160014, India.

An electrochemical hybridization assay is described for the determination of microRNA-21. Fluorine tin oxide (FTO) sheets were coated with carboxylated graphene oxide followed by deposition of gold-platinum bimetallic nanoparticles by using chronoamperometry at a potential of -0.2 V for 350 s. Read More

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http://dx.doi.org/10.1007/s00604-019-3302-3DOI Listing
February 2019
3.741 Impact Factor

Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.

Cerebellum 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Whole-brain voxel-based morphometry (VBM) studies revealed patterns of patchy atrophy within the cerebellum of Friedreich's ataxia patients, missing clear clinico-anatomic correlations. Studies so far are lacking an appropriate registration to the infratentorial space. To circumvent these limitations, we applied a high-resolution atlas template of the human cerebellum and brainstem (SUIT template) to characterize regional cerebellar atrophy in Friedreich's ataxia (FRDA) on 3-T MRI data. Read More

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http://dx.doi.org/10.1007/s12311-019-1008-zDOI Listing
February 2019

Improvement in Quality of Care for Patients with Type 2 Diabetes in Hungary Between 2008 and 2016: Results from Two Population-Based Representative Surveys.

Diabetes Ther 2019 Feb 15. Epub 2019 Feb 15.

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.

Introduction: Due to the increasing trends of recent decades, diabetes prevalence has reached a frequency of 1/11 adults worldwide. However, this disadvantageous trend has not been accompanied by worsened outcome indicators; better short-term (e.g. Read More

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http://dx.doi.org/10.1007/s13300-019-0582-xDOI Listing
February 2019

Mathematical models applied to thyroid cancer.

Biophys Rev 2019 Feb 15. Epub 2019 Feb 15.

Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.

Thyroid cancer is the most prevalent endocrine neoplasia in the world. The use of mathematical models on the development of tumors has yielded numerous results in this field and modeling with differential equations is present in many papers on cancer. In order to know the use of mathematical models with differential equations or similar in the study of thyroid cancer, studies since 2006 to date was reviewed. Read More

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http://dx.doi.org/10.1007/s12551-019-00504-7DOI Listing
February 2019

Genetic relationships among subspecies of Capparis spinosa L. from Tunisia by using ISSR markers.

Mol Biol Rep 2019 Feb 15. Epub 2019 Feb 15.

Department of Biology, Laboratory of Plant Biotechnology, Centre Urbain Nord, National Institute of Applied Sciences and Technologies (INSAT), B.P. 676, 1080, Tunis Cedex, Tunisia.

In Tunisia, Capparis spinosa L. is widely distributed in different geographic areas. Although it has been extensively studied morphologically, the phylogenetic relationships by using molecular markers among Capparis taxa are still unclear. Read More

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http://dx.doi.org/10.1007/s11033-019-04676-zDOI Listing
February 2019

Effects of channel morphology on nitrate retention in a headwater agricultural stream in Lake Chaohu Basin, China.

Environ Sci Pollut Res Int 2019 Feb 15. Epub 2019 Feb 15.

School of Resources and Environmental Engineering, Hefei University of Technology, Hefei, 230009, China.

Five field tracer experiments and relevant detailed investigations of physical characterizations were conducted to investigate the effects of channel geomorphic settings on nitrate uptake efficiency on a 310-m long geomorphically distinct stream reach in a headwater agricultural stream in Hefei District, Lake Chaohu Basin. The model-fitted parameters from the one-dimensional transport with inflow and storage model were used to estimate the transient storage metric ([Formula: see text]) and determine the total nitrate uptake coefficient (k) for the study reach. And then, a nutrient spiraling approach was applied to reach-scale nitrate uptake estimates (S, V, and U). Read More

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http://dx.doi.org/10.1007/s11356-019-04484-9DOI Listing
February 2019

Detection of outliers in pollutant emissions from the Soto de Ribera coal-fired power plant using functional data analysis: a case study in northern Spain.

Environ Sci Pollut Res Int 2019 Feb 15. Epub 2019 Feb 15.

Department of Mathematics, Faculty of Sciences, University of Oviedo, 33007, Oviedo, Spain.

For more than a century, air pollution has been one of the most important environmental problems in cities. Pollution is a threat to human health and is responsible for many deaths every year all over the world. This paper deals with the topic of functional outlier detection. Read More

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http://dx.doi.org/10.1007/s11356-019-04435-4DOI Listing
February 2019

Dynamic gas extraction of iodine in combination with a silver triangular nanoplate-modified paper strip for colorimetric determination of iodine and of iodine-interacting compounds.

Mikrochim Acta 2019 Feb 15;186(3):188. Epub 2019 Feb 15.

Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 119991, Moscow, Russia.

A method is described for sensitive and selective detection of iodine by using a paper strip modified with silver triangular nanoplates (AgTNPs). It is based on the extraction of iodine from a solution into a flow of air via dynamic gas extraction and transferring it through a reactive paper modified with AgTNPs. The interaction of AgTNPs with iodine results in a color change from blue to white. Read More

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http://dx.doi.org/10.1007/s00604-019-3300-5DOI Listing
February 2019

Lantibiotic Nisin Applied in Broiler Rabbits and Its Effect on the Growth Performance and Carcass Quality.

Probiotics Antimicrob Proteins 2019 Feb 15. Epub 2019 Feb 15.

Institute of Animal Physiology, Centre of Biosciences of the Slovak Academy of Sciences, Šoltésovej 4-6, 04001, Košice, Slovakia.

Nisin is a bacteriocin marketed as Nisaplin. The aim of this study was to follow the effect of commercial lantibiotic nisin on the growth performance and carcass quality of broiler rabbits. The increase of average daily gain (by 9. Read More

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http://dx.doi.org/10.1007/s12602-019-9525-0DOI Listing
February 2019

Determination of alkaline phosphatase activity based on enzyme-triggered generation of a thiol and the fluorescence quenching of silver nanoclusters.

Mikrochim Acta 2019 Feb 15;186(3):180. Epub 2019 Feb 15.

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Industrial Park, Suzhou, 215123, China.

A fluorimetric method is described for the determination of alkaline phosphatase (ALP) activity. It is based on the use of polyethyleneimine-coated silver nanoclusters (AgNCs), which display an intense blue fluorescence peaking at 450 nm (under 375 nm excitation). ALP catalyzes the dephosphorylation of the thiophosphate amifostine to generate a thiol that binds to the AgNCs and causes its fluorescence to be quenched. Read More

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http://dx.doi.org/10.1007/s00604-019-3301-4DOI Listing
February 2019
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