106,744 results match your criteria Applicable Analysis And Discrete Mathematics[Journal]


Cooling-field dependence of dipole-induced loop bias.

Nanotechnology 2019 Apr 17. Epub 2019 Apr 17.

College of Sciences, Shenyang, CHINA.

In ferromagnet/antiferromagnet bilayers and core/shell nanoparticles, an exchange-bias-like loop bias phenomenon in the ferromagnet is observed solely due to the long-range dipolar interactions between ferromagnet and antiferromagnet. With increasing cooling field, the loop bias field may increase from zero in the bilayers or from a negative value in the core/shell nanoparticles to a positive saturated value, depending on the interfacial dipolar interaction and/or ferromagnetic/antiferromagnetic thickness. Using a modified Monte-Carlo method and the Meiklejohn-Bean model, the interfacial dipole fields (up to several teslas) and the domain sizes imprinted on the interfacial antiferromagnet are explicitly calculated to elucidate the cooling-field dependence of loop bias, which is governed by distinct mechanisms at the flat and curved interfaces. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1a57DOI Listing

Cognitive fatigue and cortical-striatal network in old age.

Aging (Albany NY) 2019 Apr 17. Epub 2019 Apr 17.

School of Nursing, University of Rochester Medical Center, Rochester, NY 14623, USA.

Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort. Here we examined the relationship between the cortical-striatal network and CF (assessed by the 18-item visual analogue scale) when a group of cognitively and physically healthy older adults participated in a 30-minute cognitively fatiguing task-related fMRI experiment. We also explored whether CF would interfere with the "Posterior-Anterior Shifting in Aging" (PASA) phenomenon, an aging-associated neural reliance on frontal regions to support cognitive capacity. Read More

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http://dx.doi.org/10.18632/aging.101915DOI Listing

Heterologous Prime-Boost Enhances the Antitumor Immune Response Elicited by Plant-Virus-Based Cancer Vaccine.

J Am Chem Soc 2019 Apr 16. Epub 2019 Apr 16.

Department of Biomedical Engineering , Case Western Reserve University , 10900 Euclid Avenue , Cleveland , Ohio 44106 , United States.

New cancer vaccine strategies are required to vanquish the self-tolerance and elicit robust immune responses against tumor-associated antigens and/or neoantigens. Contemporary approaches in nanomedicine center on the use of a single nanocarrier modified with multiple copies of multiple different functional domains, e.g. Read More

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http://pubs.acs.org/doi/10.1021/jacs.9b01523
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http://dx.doi.org/10.1021/jacs.9b01523DOI Listing
April 2019
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Augmented Reality in Emergency Medicine: A Scoping Review.

J Med Internet Res 2019 Apr 17;21(4):e12368. Epub 2019 Apr 17.

Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, United States.

Background: Augmented reality is increasingly being investigated for its applications to medical specialties as well as in medical training. Currently, there is little information about its applicability to training and care delivery in the context of emergency medicine.

Objective: The objective of this article is to review current literature related to augmented reality applicable to emergency medicine and its training. Read More

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http://dx.doi.org/10.2196/12368DOI Listing

Antibacterial potential associated with drug-delivery built TiO nanotubes in biomedical implants.

AMB Express 2019 Apr 16;9(1):51. Epub 2019 Apr 16.

Dentistry University, School of Health Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, P.O. Box 6681, Porto Alegre, 90619-900, Brazil.

The fast evolution of surface treatments for biomedical implants and the concern with their contact with cells and microorganisms at early phases of bone healing has boosted the development of surface topographies presenting drug delivery potential for, among other features, bacterial growth inhibition without impairing cell adhesion. A diverse set of metal ions and nanoparticles (NPs) present antibacterial properties of their own, which can be applied to improve the implant local response to contamination. Considering the promising combination of nanostructured surfaces with antibacterial materials, this critical review describes a variety of antibacterial effects attributed to specific metals, ions and their combinations. Read More

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http://dx.doi.org/10.1186/s13568-019-0777-6DOI Listing

Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor.

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Background: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

Methods: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. Read More

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http://dx.doi.org/10.1007/s00345-019-02754-2DOI Listing

Anatomical assessment of the digastric branch of the facial nerve as a landmark to localize the extratemporal facial nerve trunk.

Surg Radiol Anat 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 350 W. Thomas Rd., Phoenix, AZ, 85013, USA.

Purpose: Localization of the facial nerve trunk (FNT) [i.e., the portion of the facial nerve between the stylomastoid foramen (SMF) and pes anserinus] may be required during various surgical interventions such as parotidectomy and hypoglossal-facial anastomosis. Read More

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http://dx.doi.org/10.1007/s00276-019-02222-xDOI Listing

Hygiene in medical education - Increasing patient safety through the implementation of practical training in infection prevention.

GMS J Med Educ 2019 15;36(2):Doc15. Epub 2019 Mar 15.

University Hospital Leipzig, Centre for Infection Medicine (ZINF), Institute of Hygiene, Hospital Epidemiology and Environmental Health, Leipzig, Germany.

Insufficient hygiene knowledge increases the risk of hospital-acquired infections through insufficient compliance and therefore poses a potential risk to patient safety. Therefore in 2015 the teaching project "OT Training" was introduced at the Faculty of Medicine (MF) Leipzig and a restructuring of the series of lectures and practical training on the topic of "Hygiene" was developed and integrated in the medical study curriculum. The "OT Training" in the pre-clinical component and the didactic restructuring of the hygiene workshops in the hospital semester were comprehensively developed by means of the currently applicable learning objective catalogues and have already been tested in existing teaching (per year N=320 students; 2015-17: N= 960). Read More

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http://www.egms.de/en/journals/zma/2019-36/zma001223.shtml
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http://dx.doi.org/10.3205/zma001223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446469PMC
March 2019
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Advances in surgical applications of growth factors for wound healing.

Burns Trauma 2019 5;7:10. Epub 2019 Apr 5.

Division of Plastic and Reconstructive Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501 Japan.

Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation , allowing for external modulation of the healing process. Perioperative drug delivery systems can enhance the biological activity of these growth factors, which have a very short half-life after topical administration. Read More

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http://dx.doi.org/10.1186/s41038-019-0148-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450003PMC

Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea.

Adv Biomed Res 2019 21;8:13. Epub 2019 Feb 21.

Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Background: To date, there is no standard approach to manage and to improve central sleep apnea (CSA). The most applicable therapeutic approaches are positive airway pressure therapy (PAP), bi-level PAP therapy (BIPAP), supplemental O and servo ventilation, or a combination of two approaches. Given the high prevalence of heart disease (HF) and/or concomitants of other diseases and opioid use worldwide; it seemingly requires evaluation of patients' conditions in response to each abovementioned approach to select the most effective approach. Read More

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http://dx.doi.org/10.4103/abr.abr_173_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425748PMC
February 2019

Refusal of antenatal care and the applicable conceptual models.

Case Rep Womens Health 2019 Apr 28;22:e00110. Epub 2019 Mar 28.

Department of Obstetrics and Gynaecology, Klerksdorp Hospital, North West Province, South Africa.

•The 'five-prong purpose' model describes the functions of antenatal care.•Addressing challenges identified with the five 'A's model prevents refusal of antenatal care.•Refusal of antenatal care leads to adverse pregnancy outcomes and socio-economic challenges. Read More

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http://dx.doi.org/10.1016/j.crwh.2019.e00110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449732PMC

Violence at work: determinants & prevalence among health care workers, northwest Ethiopia: an institutional based cross sectional study.

Ann Occup Environ Med 2019 3;31. Epub 2019 Apr 3.

1Department of Environmental and Occupational Health and Safety, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia.

Background: Workplace violence is the intentional use of power, threatened or actual, against another person or against a group, in work-related circumstances, that either results in or has a high degree of likelihood of resulting in injury, death, psychological harm, mal development, or deprivation. The aim of this study is to assess magnitude and predictors of workplace violence among healthcare workers in health facilities of Gondar city.

Methods: Institutional based cross sectional study design was employed to conduct this study. Read More

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http://dx.doi.org/10.1186/s40557-019-0288-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449966PMC

The effects of textured insoles on quiet standing balance in four stance types with and without vision.

BMC Sports Sci Med Rehabil 2019 4;11. Epub 2019 Apr 4.

1School of Health and Social Care, Teesside University, Middlesbrough, TS1 3BX UK.

Background: Wearing a textured shoe insole can decrease postural sway during static balance. Previous studies assessed bipedal and/or unipedal standing. In contrast, we aimed to investigate if textured insoles modulated postural sway during four stance types (bipedal, standard Romberg, tandem Romberg, and unipedal), with and without vision. Read More

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http://dx.doi.org/10.1186/s13102-019-0117-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449971PMC

Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study.

J Intensive Care 2019 5;7:20. Epub 2019 Apr 5.

Department of Emergency and Critical Care, Nagoya, University Graduate School of Medicine, Tsurumai-cho 64, Syowa-ku, Nagoya, Aichi 4668560 Japan.

Background: Currently, the appropriate method of management of patients with refractory septic shock remains unclear. This study aimed to evaluate the factors associated with response to epinephrine in norepinephrine-refractory septic shock.

Methods: A retrospective single-center observational study was performed using data from adult patients (≥ 18 years old) admitted to our emergency and medical intensive care unit (ICU) from January 2014 to December 2017 who had received epinephrine to treat norepinephrine-refractory septic shock. Read More

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http://dx.doi.org/10.1186/s40560-019-0377-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451296PMC

Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm.

Biomark Res 2019 4;7. Epub 2019 Apr 4.

1Center of Excellence in Tissue Engineering, Department of cell biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

Mesenchymal stem/stromal cells (MSCs) have been demonstrated to hold great potential for the treatment of several diseases. Their therapeutic effects are largely mediated by paracrine factors including exosomes, which are nanometer-sized membrane-bound vesicles with functions as mediators of cell-cell communication. MSC-derived exosomes contain cytokines and growth factors, signaling lipids, mRNAs, and regulatory miRNAs. Read More

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http://dx.doi.org/10.1186/s40364-019-0159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450000PMC

Evaluation of physiology knowledge loss in medical students of Ahvaz Jundishapur University of Medical Sciences.

Adv Med Educ Pract 2019 29;10:157-162. Epub 2019 Mar 29.

Physiology Research Center (PRC), Department of Physiology, School of Medicine, Medical Educational and Development Center (EDC), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,

Purpose: The knowledge loss or longevity of taught lessons is a major concern in medical students and all medical practitioners. This study evaluated the physiology knowledge loss in medical students in Ahvaz Jundishapur University of Medical Sciences in Iran.

Methods: A total of 265 volunteers from medical students who had previously passed the "general exam of medical basic sciences" at the end of fifth semester took a retention test (RT) to evaluate their knowledge loss of physiology. Read More

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http://dx.doi.org/10.2147/AMEP.S189029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445220PMC

Mental Healthcare Act, 2017, and addiction treatment: Potential pitfalls and trepidations.

Indian J Psychiatry 2019 Mar-Apr;61(2):208-212

Department of Psychiatry, National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.

The Mental Healthcare Act (MHCA), 2017, is enacted with an aim to promote and protect the rights of and improve the care and treatment for people affected by mental illness in India. The Act purportedly includes substance use disorder (SUD) specifically in the definition of mental illness itself. However, some of the phrases used in the definition such as "abuse" are not clear, as the current classificatory systems of mental illnesses do not have any diagnostic category termed "abuse. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_463_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425793PMC

Characterizing Preferential Adsorption of Phosphate on Binary Sorbents of Goethite and Maghaemite using in situ ATR-FTIR and 2D Correlation Spectroscopy.

Sci Rep 2019 Apr 16;9(1):6130. Epub 2019 Apr 16.

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.

Recent developments in analytics using infrared spectroscopy have enabled us to identify the adsorption mechanism at interfaces, but such methods are applicable only for simple systems. In this study, the preferential adsorption of phosphate on binary goethite and maghaemite was investigated. As a result, monodentate and bidentate complexes were the major complexes on goethite and maghaemite, respectively. Read More

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http://dx.doi.org/10.1038/s41598-019-42575-2DOI Listing

Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii.

Biochim Biophys Acta Mol Cell Res 2018 Nov 10;1865(11 Pt B):1846-1856. Epub 2018 Aug 10.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address:

Toxoplasma gondii has a complex life cycle involving different hosts and is dependent on fast responses, as the parasite reacts to changing environmental conditions. T. gondii causes disease by lysing the host cells that it infects and it does this by reiterating its lytic cycle, which consists of host cell invasion, replication inside the host cell, and egress causing host cell lysis. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2018.08.004DOI Listing
November 2018

Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics.

J Immunother Cancer 2019 Apr 15;7(1):105. Epub 2019 Apr 15.

Pfizer, San Diego, CA, USA.

The increasing use of multiple immunomodulatory (IMD) agents for cancer therapies (e.g. antibodies targeting immune checkpoints, bispecific antibodies, and chimeric antigen receptor [CAR]-T cells), is raising questions on their potential immunogenicity and effects on treatment. Read More

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http://dx.doi.org/10.1186/s40425-019-0586-0DOI Listing

Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: an experimental study.

J Orthop Surg Res 2019 Apr 15;14(1):105. Epub 2019 Apr 15.

Faculty of Medicine, Department of Orthopaedic and Traumatology, Abant Izzet Baysal University, Bolu, Turkey.

Background: Microfracture and scaffold application in the treatment of osteochondral defects is still one of the most frequently used methods in the clinic. The most important step in this treatment method is the stabilization of fibrin clot. Tranexamic acid (TA) is an antifibrinolytic agent commonly used in orthopedic surgery in recent years. Read More

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http://dx.doi.org/10.1186/s13018-019-1144-7DOI Listing

eNetXplorer: an R package for the quantitative exploration of elastic net families for generalized linear models.

BMC Bioinformatics 2019 Apr 16;20(1):189. Epub 2019 Apr 16.

Trans-NIH Center for Human Immunology (CHI), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Background: Regularized generalized linear models (GLMs) are popular regression methods in bioinformatics, particularly useful in scenarios with fewer observations than parameters/features or when many of the features are correlated. In both ridge and lasso regularization, feature shrinkage is controlled by a penalty parameter λ. The elastic net introduces a mixing parameter α to tune the shrinkage continuously from ridge to lasso. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2778-5DOI Listing
April 2019
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metamicrobiomeR: an R package for analysis of microbiome relative abundance data using zero-inflated beta GAMLSS and meta-analysis across studies using random effects models.

BMC Bioinformatics 2019 Apr 16;20(1):188. Epub 2019 Apr 16.

Gertrude H. Sergievsky Center, Columbia University, New York City, NY, USA.

Background: The rapid growth of high-throughput sequencing-based microbiome profiling has yielded tremendous insights into human health and physiology. Data generated from high-throughput sequencing of 16S rRNA gene amplicons are often preprocessed into composition or relative abundance. However, reproducibility has been lacking due to the myriad of different experimental and computational approaches taken in these studies. Read More

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http://dx.doi.org/10.1186/s12859-019-2744-2DOI Listing

Screening hysteroscopy in subfertile women and women undergoing assisted reproduction.

Cochrane Database Syst Rev 2019 Apr 16;4:CD012856. Epub 2019 Apr 16.

Department of Reproductive Medicine, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India, 632004.

Background: Screening hysteroscopy in infertile women with unexplained infertility, or prior to intrauterine insemination (IUI) or in vitro fertilisation (IVF) may reveal intrauterine pathology that may not be detected by routine transvaginal ultrasound. Hysteroscopy, whether purely diagnostic or operative may improve reproductive outcomes.

Objectives: To assess the effectiveness and safety of screening hysteroscopy in subfertile women undergoing evaluation for infertility, and subfertile women undergoing IUI or IVF. Read More

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http://dx.doi.org/10.1002/14651858.CD012856.pub2DOI Listing
April 2019
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Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor.

Biosens Bioelectron 2019 Apr 11;135:30-35. Epub 2019 Apr 11.

Department of Genetics, Faculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tzankov Blvd., 1164, Sofia, Bulgaria. Electronic address:

An automated DNA hybridization transfer in a microflow reactor is demonstrated by moving paramagnetic beads between two spatially separate solutions with different pH values. The microbeads-based microfluidic platform is fully automated and programmable. It employs a robust chemical procedure for specific DNA hybridization transfer in microfluidic devices under isothermal conditions based on reversible pH alterations. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.014DOI Listing

Visible light-triggered cargo release from donor acceptor Stenhouse adduct (DASA)-doped lyotropic liquid crystalline nanoparticles.

J Colloid Interface Sci 2019 Apr 11;548:151-159. Epub 2019 Apr 11.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:

Light-responsive nanocarriers are applicable as non-invasive, highly tunable and precisely controlled drug delivery systems. Here, we report a new nanocarrier system, achieved by doping D1, a type of green light-responsive donor acceptor Stenhouse adduct (DASA), into a lipid-based lyotropic liquid crystalline system. Time-resolved small angle X-ray scattering was used to confirm that the matrix underwent a rapid and fully reversible phase transition from lamellar to inverse cubic phase upon irradiation with green light (532 nm), reverting back on removal of light. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.04.032DOI Listing

Natural products: An upcoming therapeutic approach to cancer.

Food Chem Toxicol 2019 Apr 13. Epub 2019 Apr 13.

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India. Electronic address:

Cancer is one of the leading causes of death across the world. Different environmental and anthropogenic factors initiate mutations in different functional genes of growth factors and their receptors, anti-apoptotic proteins, self-renewal developmental proteins, tumor suppressors, transcription factors, etc. This phenomenon leads to altered protein homeostasis of the cell which in turn induces cancer initiation, development, progression and survival. Read More

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http://dx.doi.org/10.1016/j.fct.2019.04.012DOI Listing

Unidirectional presentation of membrane proteins in nanoparticle-supported liposomes.

Angew Chem Int Ed Engl 2019 Apr 16. Epub 2019 Apr 16.

Harvard Medical School, BCMP, 250 Longwood Ave, SGM 105, 02115, Boston, UNITED STATES.

Presentation of membrane proteins to host immune systems has been a challenging problem due to complexity arising from the poor in vivo stability of the membrane-mimetic media often used for solubilizing the membrane proteins. We report the use of functionalized, biocompatible nanoparticles as substrates to guide the formation of proteoliposomes that can present many copies of membrane proteins in a unidirectional manner. The approach was demonstrated to present the membrane-proximal region of the HIV-1 envelope glycoprotein. Read More

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http://doi.wiley.com/10.1002/anie.201903093
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http://dx.doi.org/10.1002/anie.201903093DOI Listing
April 2019
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Meta-analyses identify differentially expressed microRNAs in Parkinson's disease.

Ann Neurol 2019 Apr 16. Epub 2019 Apr 16.

Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.

Objective: MicroRNA-mediated (dys)regulation of gene expression has been implicated in Parkinson's disease (PD), although results of microRNA expression studies remain inconclusive. We aimed to identify microRNAs that show consistent differential expression across all published expression studies in PD.

Methods: We performed a systematic literature search on microRNA expression studies in PD and extracted data from eligible publications. Read More

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http://dx.doi.org/10.1002/ana.25490DOI Listing
April 2019
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Acquired Removability of Aspartic Protease Inhibitors by Direct Biotinylation.

Bioconjug Chem 2019 Apr 16. Epub 2019 Apr 16.

Protease inhibitors are used as both research tools and therapeutics. Many of these inhibitors consist of substrate amino acid sequence-derived structure with a transition state mimic to interact with the active site of the protease, suppressing enzymatic activity. However, once they bind, macrodilution or protein denaturation are required to remove them, limiting their usage. Read More

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http://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00195
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http://dx.doi.org/10.1021/acs.bioconjchem.9b00195DOI Listing
April 2019
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Machine Learning Approaches for Further Developing the Understanding of the Property Trends Observed in Protic Ionic Liquid Containing Solvents.

J Phys Chem B 2019 Apr 15. Epub 2019 Apr 15.

Ionic liquid containing solvent systems are candidates for very large compositional space exploration due to the immensity of the possible combination of ions and molecular species. The prediction of key properties of such multicomponent solvent systems plays a vital role in the design and optimization of their structures for specific applications. In this study we have explored two machine learning algorithms for predicting surface tension and liquid nanostructure of solvents containing a protic ionic liquid (PIL) with water and excess acid or base present. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b02072DOI Listing

Urban Frostbite: Strategies for Limb Salvage.

J Burn Care Res 2019 Apr 16. Epub 2019 Apr 16.

Section of Plastic and Reconstructive Surgery The Burn and Complex Wound Center The University of Chicago Medicine Chicago, IL.

Introduction: Under ideal circumstances, severely frostbitten extremities are rapidly rewarmed and treated with thrombolytic therapy within 6-24 hours. In an "inner city," urban environment, most patients who suffer frostbite injuries present in a delayed fashion, sustain repeated injuries further complicated by psychological issues or intoxication, and are rarely ideal candidates for thrombolytic therapy within the prescribed timeframe. We describe our experience with the treatment of urban frostbite injuries. Read More

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http://dx.doi.org/10.1093/jbcr/irz062DOI Listing

Narrative Coherence in Adolescence: Relations With Attachment, Mentalization, and Psychopathology.

J Pers Assess 2019 Apr 16:1-10. Epub 2019 Apr 16.

a Department of Psychology , Northeastern University.

Narrative coherence refers to the overall completeness of the narrative that helps the individual to draw meaning from past events. Research has predominantly focused on developmental trajectories of narrative coherence among typically developing individuals and less research sheds light on narrative coherence in adolescents facing serious psychological difficulties. This study is the first to apply Baerger and McAdams's well-validated coding scheme of narrative coherence to adolescents and to rate narrative coherence based on the content derived from the Child Attachment Interview in the context of attachment security, mentalization, and internalizing and externalizing pathology in 70 inpatient adolescents. Read More

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https://www.tandfonline.com/doi/full/10.1080/00223891.2019.1
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http://dx.doi.org/10.1080/00223891.2019.1574805DOI Listing
April 2019
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[Dynamic chromatopharmacokinetics model for components in Chinese medicine and validation in Buyang Huanwu Decoction].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):574-581

College of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Drugability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine Changsha 410208, China.

The Chinese medicine is mostly derived from plants or animals, highly polymorphic, with dynamic components which are reflected by the characteristic peaks and fingerprint peaks in chromatographic fingerprints. The chromatopharmacokinetics method for determined components is not applicable due to dynamic changes of chromatopharmacokinetics. Based on the preliminary study, dynamic pharmacokinetics mathematical model for multiple components in Chinese medicine was set up and verified by Buyang Huanwu Decoction as the model drug, applying the principle of the total quantum statistical moment(TQSM), superimposing or subtracting the relevant statistical parameters in blood samples and blank samples. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20180925.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180925.005DOI Listing
February 2019
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Technologies applicable to the removal of heavy metals from landfill leachate.

Environ Sci Pollut Res Int 2019 Apr 15. Epub 2019 Apr 15.

Facultad de Minas, Universidad Nacional de Colombia, Medellín, Colombia.

This article presents a review of the main physical, chemical, electrochemical, and biological technologies used for treating heavy metals in the wastewater of industrial processes and in synthetic aqueous solutions which could be applied to leachate from landfills. This paper outlines the generalities, operating principles, and modifications made to the technologies described. It discusses and assesses which of these have better removal rates and higher levels of efficiency in minimizing the heavy metal concentrations contained in leachates, such as mercury, chromium, lead, nickel, and copper among others. Read More

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http://link.springer.com/10.1007/s11356-019-04888-7
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http://dx.doi.org/10.1007/s11356-019-04888-7DOI Listing
April 2019
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Hemolytic uremic syndrome in a developing country: Consensus guidelines.

Pediatr Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Immunology, Hopital Europeen Georges Pompidou, INSERM UMRS 1138, Paris Descartes University, Paris, France.

Background: Hemolytic uremic syndrome (HUS) is a leading cause of acute kidney injury in children. Although international guidelines emphasize comprehensive evaluation and treatment with eculizumab, access to diagnostic and therapeutic facilities is limited in most developing countries. The burden of Shiga toxin-associated HUS in India is unclear; school-going children show high prevalence of anti-factor H (FH) antibodies. Read More

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http://link.springer.com/10.1007/s00467-019-04233-7
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http://dx.doi.org/10.1007/s00467-019-04233-7DOI Listing
April 2019
1 Read

Definition and management of odontogenic maxillary sinusitis.

Authors:
Soung Min Kim

Maxillofac Plast Reconstr Surg 2019 Dec 29;41(1):13. Epub 2019 Mar 29.

Oral and Maxillofacial Microvascular Reconstruction LAB, Ghana Health Service, Brong Ahafo Regional Hospital, P.O. Box 27, Sunyani, Brong Ahafo Ghana.

Background: Maxillary sinusitis of odontogenic origin, also known as maxillary sinusitis of dental origin or odontogenic maxillary sinusitis (OMS), is a common disease in dental, otorhinolaryngologic, allergic, general, and maxillofacial contexts. Despite being a well-known disease entity, many cases are referred to otorhinolaryngologists by both doctors and dentists. Thus, early detection and initial diagnosis often fail to detect its odontogenic origin. Read More

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http://dx.doi.org/10.1186/s40902-019-0196-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439010PMC
December 2019
2 Reads

Treatment of Periodontal Bone Defects with Stem Cells from Inflammatory Dental Pulp Tissues in Miniature Swine.

Tissue Eng Regen Med 2019 Apr 11;16(2):191-200. Epub 2019 Mar 11.

1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi China.

Background: Containing a certain proportion of mesenchymal stem cells, inflammatory dental tissue showed great tissue regeneration potential in recent years. However, whether it is applicable to promote tissue regeneration remains to be elucidated. Therefore, we evaluated the feasibility of stem cells from inflammatory dental pulp tissues (DPSCs-IPs) to reconstruct periodontal defects in miniature pigs. Read More

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http://link.springer.com/10.1007/s13770-018-00175-7
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http://dx.doi.org/10.1007/s13770-018-00175-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439131PMC
April 2019
1 Read

Healthy, safe and effective international medical student electives: a systematic review and recommendations for program coordinators.

Trop Dis Travel Med Vaccines 2019 3;5. Epub 2019 Apr 3.

3Monash Infectious Diseases, Monash Health and Monash University, Clayton, Victoria Australia.

Background: Thousands of medical students undertake international medical electives each year. These students face potentially substantial health and safety risks as well as educational and ethical challenges and therefore should undertake their electives within well-structured and coordinated programs.

Methods: We conducted a qualitative systematic review based on a pre-determined protocol. Read More

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http://dx.doi.org/10.1186/s40794-019-0081-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448218PMC

Implementation and evaluation of a quality and safety tool for ambulatory strongyloidiasis patients at high risk of adverse outcome.

Trop Dis Travel Med Vaccines 2019 3;5. Epub 2019 Apr 3.

1University of Toronto, 27 King's College Circle, Toronto, Ontario M5S1A1 Canada.

Background: Strongyloidiasis is a common infection in Canadian migrants that can cause life-threatening hyperinfection in immunosuppressed hosts. We designed and implemented a safety tool to guide management of patients with in order to prevent adverse outcomes. Methods: Patients treated at our centre for strongyloidiasis from January 1, 2013 to December 31, 2015 were identified through our ivermectin access log. Read More

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http://dx.doi.org/10.1186/s40794-019-0080-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448213PMC

A retrospective observational analysis of red blood cell transfusion practices in stable, non-bleeding adult patients admitted to nine medical-surgical intensive care units.

J Intensive Care 2019 4;7:19. Epub 2019 Apr 4.

1Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3D18, Teaching Research and Wellness Building, 3280 Hospital Drive NW, Calgary, Alberta T2N 4N1 Canada.

Background: Red blood cell (RBC) transfusions are common procedures performed in the intensive care unit (ICU). However, conservative transfusion approaches have been recommended to avoid RBC transfusions that are not clinically necessary and to achieve optimal patient outcomes. The objective of this study was to examine the utilization and costs of RBC transfusions in medical-surgical ICUs and to compare this information against clinical guideline recommendations for best practice. Read More

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http://dx.doi.org/10.1186/s40560-019-0375-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449900PMC

The association between early neurological deterioration and whole blood purine concentration during acute stroke.

Biomark Res 2019 3;7. Epub 2019 Apr 3.

1NIHR Newcastle Biomedical Research Centre and Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

Background: Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxia, may reflect the subclinical presence of vulnerable tissue. Read More

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http://dx.doi.org/10.1186/s40364-019-0158-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448300PMC

Defining compulsive exercise in eating disorders: acknowledging the exercise paradox and exercise obsessions.

J Eat Disord 2019 4;7. Epub 2019 Apr 4.

3Department of Psychology, UiT -The Arctic University of Norway, Tromsø, Norway.

Recently Dittmer et al. (JED 6:1-9, 2018). suggested a transdiagnostic definition and a clinical assessment for compulsive exercise in adolescents and adults with eating disorders. Read More

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http://dx.doi.org/10.1186/s40337-019-0238-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448210PMC

Acute cough in Italian children: parents' beliefs, approach to treatment, and the family impact.

Multidiscip Respir Med 2019 4;14:16. Epub 2019 Apr 4.

AdRes Health Economics and Outcome Research, Torino, Italy.

Background: Acute cough is the most common symptom among children in primary care, but the impact of cough episodes was never investigated in Italian families.

Methods: A cross-sectional telephone survey was conducted on a representative sample of Italian families, randomly selected from general population; a specific and validated questionnaire was used.

Results: The sample (604 calls) was uniform by geographical distribution, and by children age and gender. Read More

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http://dx.doi.org/10.1186/s40248-019-0180-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448239PMC
April 2019
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Habitual food consumption of the Belgian population in 2014-2015 and adherence to food-based dietary guidelines.

Arch Public Health 2019 5;77:14. Epub 2019 Apr 5.

Sciensano, Department of Epidemiology and public health, Unit Lifestyle and chronic diseases, Brussels, Belgium.

Background: Between 2014 and 2015 a second National Food Consumption Survey was conducted in Belgium in order to evaluate the habitual food consumption in the general Belgian population and to compare it with food-based dietary guidelines (FBDG) and results of the 2004 Food Consumption Survey.

Methods: A representative sample of the Belgian population was randomly selected from the National Population Register following a multistage stratified sampling procedure. Information on dietary intake was collected from 3146 subjects between 3 and 64 year old through two non-consecutive 24-hour dietary recalls using GloboDiet®. Read More

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http://dx.doi.org/10.1186/s13690-019-0343-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449930PMC
April 2019
2 Reads

Flutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries.

J Anim Sci Biotechnol 2019 3;10:35. Epub 2019 Apr 3.

1Department of Endocrinology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9 Street, 30-387 Krakow, Poland.

Background: Androgens are involved in the regulation of ovarian development during fetal/neonatal life. Environmental chemicals displaying anti-androgenic activities may affect multiple signal transduction pathways by blocking endogenous androgen action. The aim of the current study was to examine effects of the anti-androgen flutamide on the expression of coding transcripts and long non-coding RNAs (lncRNAs) in neonatal porcine ovaries. Read More

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http://dx.doi.org/10.1186/s40104-019-0340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446412PMC

Influence of starch sources and dietary protein levels on intestinal functionality and intestinal mucosal amino acids catabolism in broiler chickens.

J Anim Sci Biotechnol 2019 5;10:26. Epub 2019 Apr 5.

1State key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193 People's Republic of China.

Background: There is growing interest in carbohydrate and protein nutrition to enhance the efficiency of animal production. Reduced-crude protein diets depress environmental pollution and feeding cost, but the challenge to their adoption is maintaining digestive function and growth performance of birds. The present study was conducted to evaluate the influence of different dietary starch sources and protein levels on intestinal functionality and mucosal amino acid catabolism. Read More

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http://dx.doi.org/10.1186/s40104-019-0334-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449925PMC

Chloroethylating anticancer drug-induced mutagenesis and its repair in .

Genes Environ 2019 5;41:11. Epub 2019 Apr 5.

1Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Tsushima-naka, Kita-ku, Okayama, 700-8530 Japan.

Background: Chloroethylnitrosourea (CENU) derivatives, such as nimustine (ACNU) and carmustine (BCNU), are employed in brain tumor chemotherapy due to their ability to cross the blood-brain barrier. They are thought to suppress tumor development through DNA chloroethylation, followed by the formation of interstrand cross-links (ICLs) that efficiently block replication and transcription. However, the alkylation of DNA and ICLs may trigger genotoxicity, leading to tumor formation as a side effect of the chemotherapeutic treatment. Read More

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http://dx.doi.org/10.1186/s41021-019-0123-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449902PMC

Association of ACE gene polymorphism with cardiovascular determinants of trained and untrained Iranian men.

Genes Environ 2019 4;41. Epub 2019 Apr 4.

2Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, P.O. Box: 41635-1438, Rasht, Iran.

Background: The insertion (I) rather than deletion (D) of human angiotensin converting enzyme gene (ACE) is associated with lower circulating ACE activity and with endurance performance among Caucasians. The frequency of the ACE gene I/D allele in Iranian sample seems to be more similar to the Caucasians. To assess the possible relationship between I/D polymorphism of ACE gene with athletic status and selected cardiovascular indices and VO in an Iranian population, DNA samples were obtained from 57 trained and untrained men, with soccer as their main training modality. Read More

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http://dx.doi.org/10.1186/s41021-019-0126-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448307PMC