35,904 results match your criteria Appetite [Journal]
Appetite 2018 Dec 11. Epub 2018 Dec 11.
Department of Psychology, School of Social Sciences, Birmingham City University, Curzon Building, 4 Cardigan Street, Birmingham, B4 7BD, United Kingdom.
Objective: One method of influencing an individual's food consumption involves placing unhealthy snacks further away from individuals, known as the "proximity effect". However, only one laboratory study has explored the effect while both an unhealthy and a healthy option are presented simultaneously. Further, little is known about the potential underpinning mechanisms of the effect. Read More
Appetite 2018 Dec 11. Epub 2018 Dec 11.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ultra-processed foods are industrially formulated products that are convenient, highly-palatable, and contain few whole ingredients. While popular among US households regardless of SES, these foods constitute a relatively large proportion of grocery spending among low-income households participating in the Supplemental Nutrition Assistance Program (SNAP). Little is understood about the perceived factors influencing selection and consumption of these foods, particularly among households with children participating in SNAP. Read More
Appetite 2018 Dec 11. Epub 2018 Dec 11.
Department of Foods and Nutrition, University of Georgia, Athens, GA, USA. Electronic address:
Background: Modifying the type of dietary fat consumed may impact appetite, therefore having implications in weight management.
Objective: To test the effects of a 5-day, high-fat diet rich in poly-unsaturated fatty acids (PUFAs) and a diet rich in mono-unsaturated fatty acids (MUFAs) on markers of appetite.
Methods: Fifteen normal weight men participated in a randomized cross-over design with two controlled feeding trials (3d lead-in diet, pre-diet visit, 5d PUFA- or MUFA-rich diet, post-diet visit). Read More
Appetite 2018 Dec 11. Epub 2018 Dec 11.
Dept. of Agricultural Economics, Purdue University, 403 West State Street, West Lafayette, IN, 47907, USA.
Due to the decrease in fluid milk consumption as a beverage in the United States, the importance for dairy industry stakeholders to understand attribute preferences for consumer segments has increased. This paper uses a representative sample of U.S. Read More
BMC Microbiol 2018 Dec 14;18(1):215. Epub 2018 Dec 14.
State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
Background: There are growing evidences showing that gut microbiota should play an important role in host appetite and feeding behavior. However, what kind of microbe(s) and how they affect porcine appetite remain unknown.
Results: In this study, 280 commercial Duroc pigs were raised in a testing station with the circadian feeding behavior records for a continuous period of 30-100 kg. Read More
Invest New Drugs 2018 Dec 14. Epub 2018 Dec 14.
Institut Claudius Regaud, IUCT-Oncopole, Departement d'Oncologie Medicale, Toulouse, France.
Purpose To determine the maximum tolerated dose (MTD) of F14512, a topoisomerase II inhibitor designed to target cancer cells through the polyamine transport system, (three-hour daily infusion given for 3 consecutive days every 3 weeks) in platinum-refractory or resistant ovarian cancer. Other objectives were safety, pharmacokinetics (PK), PK/pharmacodynamics relationship, and efficacy. Methods This was an open-label, dose-escalation, multicenter phase I study. Read More
J Rural Med 2018 Nov 29;13(2):110-115. Epub 2018 Nov 29.
Department of Radiation Therapy, Suzuka General Hospital, Japan.
Chemoradiation therapy is among the standard treatments for cancer, which often causes a decrease in appetite and subsequent weight loss. When weight loss occurs during treatment, the external body contour changes from that indicated during initial planning, causing changes in dose distribution to the target tumor regions and organs at risk (OARs). This study aimed to examine the dose changes to both the target regions and OARs, based on the dose-volume histogram (DVH). Read More
Consult Pharm 2018 Dec;33(12):680-689
The use of medical marijuana-both the psychoactive tetrahydrocannabinol and its nonpsychoactive relative cannabidiol-is a growing practice in facilities served by senior care pharmacists. Currently, 30 states have approved its use under a variety of different regulations and for a number of conditions. Its use is bolstered by a growing number of Americans who support legalization of cannabis. Read More
Cardiovasc Diabetol 2018 Dec 13;17(1):157. Epub 2018 Dec 13.
Cardiology Division, Pontifical Catholic University of Campinas Medicine School, Rua Engenheiro Carlos Stevenson 560, Campinas, Sao Paulo, 13092-132, Brazil.
Patients with type 2 diabetes (T2DM) have a substantial risk of developing cardiovascular disease. The strong connection between the severity of hyperglycaemia, metabolic changes secondary to T2DM and vascular damage increases the risk of macrovascular complications. There is a challenging demand for the development of drugs that control hyperglycaemia and influence other metabolic risk factors to improve cardiovascular outcomes such as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina and heart failure (major adverse cardiovascular events). Read More
Sports (Basel) 2018 Dec 11;6(4). Epub 2018 Dec 11.
Department of Exercise Science, Energy Metabolism and Body Composition Laboratory, Elon University, 100 Campus Drive, Elon, NC 27244, USA.
To determine changes in appetite, affect and cortisol in response to an acute bout of resistance exercise (RE) the morning after consuming whey (WP) and casein (CP) protein and a non-caloric placebo (PLA) consumed pre-sleep, 14 active men (n = 5) and women (n = 9) consumed a single dose of 24 g WP, 48 g WP, 24 g CP, 48 g CP, or PLA 30 min pre-sleep. Prior to and immediately after RE, appetite, affect and cortisol were assessed. Significant time effects were observed for Energetic Arousal and Tense Arousal ( = 0. Read More
Nutrients 2018 Dec 7;10(12). Epub 2018 Dec 7.
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Acute exercise can induce either a compensatory increase in food intake or a reduction in food intake, which results from appetite suppression in the post-exercise state. The timing of food choice-choosing for immediate or later consumption-has been found to influence the healthfulness of foods consumed. To examine both of these effects, we tested in our study whether the timing of food choice interacts with exposure to exercise to impact food choices such that choices would differ when made prior to or following an exercise bout. Read More
Appetite 2018 Dec 10. Epub 2018 Dec 10.
Penn State College of Medicine, Penn State Health Milton S. Hershey Medical Center, United States.
Background: Orthorexia nervosa (ON) is characterized by obsessions about eating healthily and rigid adherence to a perceived healthy diet. This study uses the Eating Habits Questionnaire to investigate the relationship of ON symptoms with self-reported food intake, eating-related impairment, obsessive compulsive disorder symptoms (OCD), gender, and BMI while controlling for other eating disordered symptoms. The aim of this study is to provide further evidence for the construct of ON as distinct from other forms of disordered eating. Read More
JAMA Oncol 2018 Dec 13:e184475. Epub 2018 Dec 13.
Department of Medicine, University of California at San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco.
Importance: The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in patients with estrogen receptor-positive (ER+), endocrine therapy-resistant breast cancers.
Objective: To assess the maximum tolerated dose (MTD), safety, and activity of alpelisib, an oral, PI3Kα-specific inhibitor, plus fulvestrant in patients with ER+ advanced breast cancer (ABC).
Design, Setting, And Participants: An open-label, single-arm, phase 1b study of alpelisib plus fulvestrant was conducted at 10 centers in 5 countries. Read More
Nihon Ronen Igakkai Zasshi 2018 ;55(4):675-678
Graduate School of Comprehensive Human Science, Faculty of Health and Sports Sciences, University of Tsukuba.
A 94 year old woman with a late-onset paraphrenia was referred to our clinic from a community care center. The patient showed symptoms of paranoia and auditory hallucination. The patient was in conflict with her neighbors regarding noise-related problems and was experiencing loss of appetite. Read More
J Oleo Sci 2018 Dec 12. Epub 2018 Dec 12.
Department of Pharmacy, Faculty of Pharmaceutical Sciences, Nagasaki International University.
Ghrelin is a stomach-derived peptide hormone with an appetite-stimulating effect. Octanoylation on the serine-3 residue of ghrelin by ghrelin O-acyl transferase (GOAT) is essential for its orexigenic effect. Mature octanoylated ghrelin is generated by the C-terminal cleavage of octanoylated proghrelin via prohormone convertases (furin, PC1/3, or PC2). Read More
J Med Case Rep 2018 Dec 13;12(1):367. Epub 2018 Dec 13.
Department of Medicine, Teaching Hospital Kandy, Kandy, Sri Lanka.
Background: Liver abscess has formerly been a polymicrobial infection. Currently, liver abscess due to Klebsiella pneumoniae is increasingly reported, predominantly in Southeast Asia for unknown reasons. Liver abscess due to Klebsiella pneumonia has never been previously reported in Sri Lanka. Read More
CNS Drugs 2018 Dec 6. Epub 2018 Dec 6.
Lindner Center of HOPE, Mason, OH, USA.
This paper reviews past and current progress in developing pharmacologic agents for the treatment of individuals with bulimia nervosa (BN). We searched the literature and clinical trial registries for compounds studied in BN, the related condition, binge eating disorder (BED), and preclinical models of binge-eating behavior. Drug classes evaluated included antidepressants, antiepileptic drugs, stimulants and other medications for attention-deficit/hyperactivity disorder, opioid antagonists, and weight loss agents, among others. Read More
Anticancer Drugs 2019 Jan;30(1):91-97
Neuro-Cognitive Unit, Rambam Health Care Campus.
Objectives: In patients with cancer, the use of medical cannabis has increased significantly during the recent years. There is evidence that cannabis consumption may affect cognitive performance; however, this potential effect has not been investigated prospectively in patients with cancer to date. We aimed to evaluate the effect of cannabis consumption on cognitive abilities as well as on symptom relief in patients with cancer during chemotherapy treatment. Read More
J Gen Virol 2018 Dec 12. Epub 2018 Dec 12.
2Institute of Virology, College of Plant Protection, Hunan Agricultural University, Changsha, Hunan 410128, PR China.
Ascoviruses are enveloped, circular, double-stranded DNA viruses that can effectively control the appetite of lepidopteran larvae, thereby reducing the consequent damage and economic losses to crops. In this study, the virion of a sequenced Heliothis virescens ascovirus 3i (HvAV-3i) strain was used to perform proteomic analysis using both in-gel and in-solution digestion. A total of 81 viral proteins, of which 67 were associated with the virions, were identified in the proteome of HvAV-3i virions. Read More
Arq Gastroenterol 2018 Jul-Sep;55(3):290-295
Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.
Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.
Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.
Methods: A cross-sectional study. Read More
Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.
Laboratory of Bariatric and Nutritional Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Human neuroimaging studies have consistently reported changes in cerebellar function and integrity in association with obesity. To date, however, the nature of this link has not been studied directly. Emerging evidence suggests a role for the cerebellum in higher cognitive functions through reciprocal connections with the prefrontal cortex. Read More
Appetite 2018 Dec 8. Epub 2018 Dec 8.
Department of Human Ecology, University of California, Davis 1309 Hart Hall, One Shields Avenue, Davis, CA, 95616, USA. Electronic address:
Home-packed lunches have been found to be of lower nutritional quality than school-bought lunches, yet little is known about family-based factors associated with lunch packing. The current exploratory study examines parental and family predictors of fruits and vegetables packed in lunches, hypothesizing parents' nutrition knowledge and authoritative parenting as well as children's involvement in lunch decisions would relate to packing more fruits and vegetables, while financial difficulties would relate to packing fewer. Ninety parent-child dyads from 4th-6th grade participated for 5 consecutive school days. Read More
Appetite 2018 Dec 8. Epub 2018 Dec 8.
Department of Organic Food Quality and Food Culture, Faculty of Organic Agricultural Sciences, University of Kassel, Nordbahnhofstrasse 1A, 37213, Witzenhausen, Germany.
This study aims to investigate consumers' green food purchase intentions using a survey conducted in Qingdao, Shandong Province, China. Based on the Theory of Planned Behavior (TPB), it models the influences of Chinese culture and consumer characteristics towards purchasing green food products. According to TPB, the behavioral intention is determined by attitude, subjective norms and perceived behavioral control, whereas subjective norms vary according to differences in cultural systems. Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Department of Nutrition, Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Obesity as a multifactorial disorder has been shown a dramatically growing trend recently. Besides genetic and environmental factors, dysregulation of the endocannabinoid system tone is involved in the pathogenesis of obesity. This study reviewed the potential efficacy of Oleoylethanolamide (OEA) as an endocannabinoid-like compound in the energy homeostasis and appetite control in people with obesity. Read More
Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.
Department of Entomology, Cornell University, Ithaca, NY, 14853, USA.
The proximate forces that create omnivores out of herbivores and predators have long fascinated ecologists, but the causal reasons for a shift to omnivory are poorly understood. Determining what factors influence changes in trophic position are essential as omnivory plays a central role in theoretical and applied ecology. We used sevenspotted lady beetles (Coccinella septempunctata) to test how prey nutrient content affects beetles' propensity to engage in herbivory. Read More
J Mol Neurosci 2018 Dec 10. Epub 2018 Dec 10.
CURE/Digestive Diseases Research Center, Department of Medicine at the David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide expressed both centrally and peripherally. CGRP has been shown to be involved in arteriolar dilation, cardiovascular regulation, pain transmission, migraine, and gastrointestinal physiology. Our current research is aimed at analyzing CGRP's impact on appetite/satiety, body metabolism, and energy homeostasis. Read More
Front Behav Neurosci 2018 26;12:269. Epub 2018 Nov 26.
Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
The euphoric feeling described after running is, at least in part, due to increased circulating endocannabinoids (eCBs). eCBs are lipid signaling molecules involved in reward, appetite, mood, memory and neuroprotection. The aim of this study was to investigate whether activities other than running can increase circulating eCBs. Read More
Curr Opin Nephrol Hypertens 2018 Dec 10. Epub 2018 Dec 10.
Department of Pharmacology, Center for Hypertension Research, Obesity Research & Education Initiative, Iowa Neuroscience Institute, Abboud Cardiovascular Research Center, and Fraternal Order of Eagles' Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, USA.
Purpose Of Review: Obesity represents the primary challenge to improving cardiovascular health, and suppression of resting metabolic rate (RMR) is implicated in the maintenance of obesity. Increasing evidence supports a major role for the renin-angiotensin system (RAS) within the brain in the control of RMR.
Recent Findings: The angiotensin II (ANG) Agtr1a receptor colocalizes with the leptin receptor (Lepr) primarily within cells of the arcuate nucleus (ARC) of the hypothalamus that also express Agouti-related peptide (Agrp). Read More
Appetite 2018 Dec 7;133:400-404. Epub 2018 Dec 7.
Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), London, United Kingdom.
Recent theoretical models and empirical research have indicated that momentary negative affect increases the likelihood of binge eating episodes for individuals with bulimia nervosa and binge eating disorder. However, relatively little research has explored the potential for positive mood to serve a protective effect in reducing the likelihood of overeating behaviour in bulimia nervosa and binge eating disorder. The current study included 30 women with bulimia nervosa or binge eating disorder in a within-subjects crossover design. Read More
Clin Genitourin Cancer 2018 Sep 29. Epub 2018 Sep 29.
Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
Background: Previous studies have revealed that higher exposure of axitinib leads to better prognosis in metastatic renal-cell carcinoma. We thus assessed individualized dosing of axitinib on the basis of the first-dose area under the concentration-time curve from 0 to 12 hours (AUC) for sunitinib-pretreated metastatic renal-cell carcinoma patients.
Patients And Methods: In this prospective single-arm trial, the starting dose of axitinib was 5 mg twice daily. Read More
Schizophr Res 2018 Dec 7. Epub 2018 Dec 7.
Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA, United States. Electronic address:
Objective: Schizophrenia is associated with an increased prevalence of the metabolic syndrome. Patients receiving antipsychotic medications, including olanzapine, are at further risk. Ghrelin is an appetite-stimulating peptide hormone, although whether blood levels are altered by antipsychotic treatment, remains unclear. Read More
Harm Reduct J 2018 Dec 7;15(1):61. Epub 2018 Dec 7.
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, P.O. Box 100165, 1225 Center Drive, Room 3146, Gainesville, FL, 32610-0165, USA.
Background: Though marijuana use has previously been associated with risky alcohol use, studies often do not delineate between the effect of recreational versus therapeutic marijuana use, particularly among people living with HIV (PLWH). In this study, we examined the association between recreational versus therapeutic marijuana use to manage HIV symptoms (i.e. Read More
Ann Palliat Med 2018 Sep 5. Epub 2018 Sep 5.
Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Background: Cancer patients often present with several concurrent symptoms. There is evidence to suggest that related symptoms can cluster together in stable groups. The present study sought to identify symptom clusters in advanced cancer patients using the Edmonton Symptom Assessment System (ESAS) in a palliative outpatient radiotherapy clinic. Read More
Ann Palliat Med 2018 Sep 5. Epub 2018 Sep 5.
McGill Nutrition and Performance Laboratory, Supportive and Palliative Care Division, McGill University Health Centre, Montreal, Quebec, Canada.
Cancer cachexia (CC) is common in advanced cancer and is accompanied by negative effects on health-related quality of life (HRQOL). However, methods to identify the impact of CC on HRQOL are limited. Single questionnaire items may provide insight on the effect of CC on HRQOL. Read More
Am J Respir Crit Care Med 2018 Dec 6. Epub 2018 Dec 6.
Case Western Reserve University, Cleveland, Ohio, United States.
Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic options for the treatment of sleepiness in this population are limited. Read More
Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Physiology and Nuclear Medicine, Hvidovre University Hospital.
Dietary fat, and particularly fatty acids from hydrolyzed triglycerides, reduce appetite, whereas, paradoxically, a high-fat diet leads to excess calorie intake and weight gain. We therefore hypothesized that the appetite-regulating effects of dietary fat is perturbed in obesity. Ten men with severe obesity (median BMI 51. Read More
BMC Complement Altern Med 2018 Dec 5;18(1):323. Epub 2018 Dec 5.
Institute of Nutrition, China Medical University, Taichung, 40402, Taiwan.
Background: Weight reduction frequently occurs in patients receiving vagus nerve stimulation (VNS) therapy. Therefore, we hypothesized that during dietary intervention for weight loss, auricular electric stimulation (AES), an alternative of VNS, accelerates weight loss by increasing white adipose tissue (WAT) browning and increases energy expenditure.
Methods: C57BL/6J male mice were fed a high-fat diet for 5 wk. Read More
Nutrition 2018 Sep 7;60:6-10. Epub 2018 Sep 7.
Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore; Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore, Singapore. Electronic address:
Objectives: It has been demonstrated that leptin influences the energy balance by regulating appetite and increasing energy expenditure (EE). However, the relationship between circulating leptin and EE is confounded owing to variations in body composition. The aim of this study was to determine the role of circulating leptin in energy regulation and to examine whether the leptin-mediated changes in EE are associated with adiposity among healthy adults living in Singapore. Read More
Appetite 2018 Nov 30. Epub 2018 Nov 30.
Amsterdam School of Communication Research (ASCoR), University of Amsterdam, Amsterdam, the Netherlands; Trimbos Institute, Netherlands Institute for Mental Health and Addiction, Utrecht, the Netherlands.
Background: This study examined whether seeing food-related TV content affected the accessibility of a hedonic eating goal differently for people scoring relatively high or low on eating restraint (i.e., chronic dieting) and perceived self-regulatory success (i. Read More
Appetite 2018 Nov 30;133:362-369. Epub 2018 Nov 30.
Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
'Food addiction' refers to the idea that certain highly palatable foods can trigger an addictive-like process in susceptible individuals. The aim of this study was to assess the prevalence and clinical significance of 'food addiction' symptoms in binge eating disorder (BED) using the second version of the Yale Food Addiction Scale (YFAS 2.0). Read More
Appetite 2018 Nov 30. Epub 2018 Nov 30.
USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates, Houston, TX, 77030-2600, USA. Electronic address:
Currently, a number of questionnaires exist assessing a wide range of food parenting practices with young children. In 2016, a concept map covering three food parenting domains-coercive control, parental structure, and autonomy support-was published along with a critical review of the literature. Mapping existing food parenting questionnaires onto these concepts showed that the major focus had been on coercive control. Read More
Appetite 2018 Nov 30;133:313-323. Epub 2018 Nov 30.
Institute of Experimental Psychology, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address:
By means of event-related potentials (ERPs), the present study intended to extend previous findings on how the different processing stages of attentional selection are altered by the participants' motivational state depending on their saturation level. Forty-four normal-weight (mean BMI: 21.34, SD = 1. Read More
Appetite 2018 Nov 30;133:324-336. Epub 2018 Nov 30.
Institute of Psychology, University of Tartu, Näituse 2, 50409, Tartu, Estonia. Electronic address:
Automatic detection of important and unexpected stimuli in the visual environment is crucial for survival. We sought to explore whether visual food stimuli are detected already in the pre-attentive stimulus processing phase, and whether hunger enhances such automatic detection. To attain these goals, we adapted an electroencephalography paradigm - visual mismatch negativity (vMMN). Read More
Gen Comp Endocrinol 2018 Nov 30. Epub 2018 Nov 30.
College of Animal Science and Technology, Shandong Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, 271018, PR China. Electronic address:
Ghrelin, one of the most important appetite regulating peptides, is involved in the regulation of energy homeostasis. The anorexia effect of ghrelin in chickens is contrary to that of ghrelin in mammals. In the present study, the effects of feeding status and dietary energy level on plasma total ghrelin levels and expression were studied in broilers. Read More
Int J Epidemiol 2018 Dec 1. Epub 2018 Dec 1.
Department of Child and Adolescent Psychiatry & Psychology, Erasmus MC, Rotterdam, The Netherlands.
Background: Although studies showed that an adverse intrauterine environment increases the obesity risk in adulthood, little is known about consequences of fetal growth and birth size for eating behaviour. We examined whether fetal and birth size are associated with childhood eating behaviour.
Methods: Participants were 4350 mother-child dyads of the prospective cohort study Generation R. Read More
J Med Chem 2018 Dec 3. Epub 2018 Dec 3.
Departments of Chemistry, Oncology, and Medical Imaging , University of Western Ontario , London , ON N6A 4L6 , Canada.
A chimeric drug design approach, merging the structure of an antagonist and an inverse agonist, results in a new molecular scaffold for targeting the ghrelin receptor (GHSR). Read More
J Vet Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.
Kindred Biosciences, Inc., Burlingame, California.
Mirtazapine is classified as a weight gain drug in cats, and the purpose of this study was to evaluate its efficacy in cats experiencing unintended weight loss. This was a multi-center, double-blind, placebo-controlled, randomized clinical study in client-owned cats ≥1 year of age, weighing ≥2 kg, with a documented loss (≥5%) in body weight. Cats were treated once daily with either 2 mg/cat mirtazapine transdermal ointment (n = 83) or placebo (n = 94) (Per Protocol population) applied to the inner surface of the pinna for 14 ± 3 days. Read More
Nat Rev Drug Discov 2018 Nov 30. Epub 2018 Nov 30.
Faculty of Biology & Biotechnology, Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany.
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. Read More
Nat Commun 2018 11 30;9(1):5103. Epub 2018 Nov 30.
Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Palatable foods (fat and sweet) induce hyperphagia, and facilitate the development of obesity. Whether and how overnutrition increases appetite through the adipose-to-brain axis is unclear. O-linked beta-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) couples nutrient cues to O-GlcNAcylation of intracellular proteins at serine/threonine residues. Read More
Anticancer Res 2018 Dec;38(12):6911-6917
Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Background/aim: Nanoparticle albumin-bound (nab)-paclitaxel has demonstrated antitumor activity against advanced gastric cancer. However, gastric cancer patients can be difficult to treat with the recommended dose because of the high incidence of adverse toxicities. The aim of this study was to evaluate the safety and effectiveness of low-dose nab-paclitaxel in a multicenter, single-arm, phase II study. Read More