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Rev Assoc Med Bras (1992) 2022 May;68(5):685-690

Giresun University Faculty of Medicine, Department of Pathology - Giresun, Turkey.

Objective: This study aimed to examine the impact of the coronavirus disease 2019 (COVID-19) pandemic on appendicitis and the relevant outcomes in a tertiary hospital, designated as a "pandemic institution" by the Ministry of Health, between pre-COVID-19 and post-COVID-19, i.e., between 2019 and 2020, of the identical period in terms of the annual schedule. Read More

Int J Colorectal Dis 2022 May 18. Epub 2022 May 18.

Department of Surgery, Maasstad Ziekenhuis, Rotterdam, The Netherlands.

Background: Radiologic imaging can accurately diagnose acute appendicitis, but little is known about its discriminatory capacity between complicated and uncomplicated appendicitis.

Objective: This study aims to investigate the accuracy of imaging in discriminating complicated from uncomplicated appendicitis.

Methods: Data was used from the prospective, nationwide, observational SNAPSHOT appendicitis database, including patients with suspected acute appendicitis who were planned for an appendectomy. Read More

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Department of Pediatric Surgery, Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central EPE, Lisboa, Portugal.

This study reports an exceptional case of a 14-year-old girl with sickle cell disease that was diagnosed with agenesis of the vermiform appendix and ileal duplication. Both consist of extremely rare gastrointestinal malformations whose association has never been described. The preadolescent girl presented with abdominal pain and vomiting, and the ultrasound was suggestive of acute appendicitis. Read More

Am Surg 2022 May 16:31348221101493. Epub 2022 May 16.

Department of Surgery, 12222University of California Los Angeles School of Medicine, Los Angeles, CA, USA.

Background: Frailty is a potential modifiable predictor of surgical outcomes in older adults. The impact of frailty following appendectomy, a common urgent operation, is unknown for older adults. The study aim was to assess if frailty is associated with worse perioperative outcomes after appendectomy in older adults. Read More

Br J Surg 2022 May;109(6):503-509

Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.

Background: Non-operative management of uncomplicated acute appendicitis is an option, but omission of antibiotics from the regimen has not been tested.

Methods: A double-blind, placebo-controlled, superiority RCT in adults with CT-confirmed uncomplicated acute appendicitis was designed to compare placebo with antibiotics (intravenous ertapenem followed by oral levofloxacin and metronidazole). The primary endpoint was treatment success (resolution resulting in discharge without appendicectomy within 10 days); secondary outcomes included pain scores, complications, hospital stay, and return to work. Read More

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):331-335

Pakistan Institute of Medical Sciences, Islamabad, Pakistan.

Background: Acute appendicitis is a common surgical emergency and if complicated, manifesting as abscess, perforation, suppurative or gangrenous appendicitis, carries significant morbidity and mortality. Its early preoperative diagnosis can improve outcome in patients and reduce incidence of negative appendectomies. It, however, mandates identification of new diagnostic parameters for it. Read More

J Int Med Res 2022 May;50(5):3000605221096273

Department of Gastroenterology, Jingling Hospital, Medical School of Nanjing University, Nanjing, China.

Endoscopic mucosal resection (EMR) was originally described in 1973 and is currently a popular practice used in treating polyps, small adenomas, and early cancers. Although the safety of EMR has been proven in numerous studies, complications occur occasionally. We report a case in which the patient complained of severe upper abdominal pain and who was diagnosed with acute appendicitis after colorectal EMR. Read More

Cureus 2022 Apr 12;14(4):e24086. Epub 2022 Apr 12.

General Surgery, Brookwood Baptist Health, Jasper, USA.

Appendicitis is a very common indication for surgery, although in recent years uncomplicated cases have often been managed with antibiotics. In this case, we discuss a patient who presented to the emergency department with a case of seemingly uncomplicated acute appendicitis. Physical exam, history, and imaging indicated that this was due to an ingested foreign body, specifically a dental crown, that had impacted the appendix. Read More

Pan Afr Med J 2022 4;41:178. Epub 2022 Mar 4.

Cheikh Anta Diop University, Dakar, Senegal.

Mesenteric pseuodycst is a very rare benign childhood tumor, accounting for less than 1 out of 250,000 hospital admissions. We here report a case of giant mesenteric pseudocyst incidentally detected in a 11-year-old boy with acute appendicitis. He complained of persistent abdominal pain for the past 48 hours. Read More

J Infect Dev Ctries 2022 Apr 30;16(4):717-725. Epub 2022 Apr 30.

Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia / Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Intestinal amoebiasis is a parasitic infection caused by Entamoeba histolytica. It is commonly found in developing countries with poor hygiene. A rare, life-threatening complication of amoebiasis is fulminant necrotizing amoebic colitis (FulNAC). Read More

Clin Lab 2022 May;68(5)

Background: Acute appendicitis is one of the most common abdominal emergencies worldwide. Biomarkers and imaging are valuable adjuncts to history and examination. Differentiating complicated and uncomplicated appendicitis is essential. Read More

Eur J Gen Pract 2022 Dec;28(1):95-101

Department of General Practice and Elderly Care Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: The diagnostic value of C-reactive protein (CRP) for appendicitis in children has not been evaluated in primary care. As biochemical responses and differential diagnoses vary with age, separate evaluation in children and adults is needed.

Objectives: To determine whether adding CRP to symptoms and signs improves the diagnosis of appendicitis in children with acute abdominal pain in primary care. Read More

Br J Surg 2022 May 9. Epub 2022 May 9.

Departments of Surgery, Radiology, and Pathology, Hackensack University Medical Center, Hackensack, New Jersey, USA.

Cir Esp (Engl Ed) 2022 May 4. Epub 2022 May 4.

Cirugía General, Hospital Clínico San Cecilio, Granada, Spain.

Eur J Trauma Emerg Surg 2022 May 7. Epub 2022 May 7.

Department of General Surgery B., Emek Medical Center, Yitshak Rabin Boulevard 21, 1834111, Afula, Israel.

Background: Acute appendicitis (AA) is one of the most common surgical emergencies worldwide. It's classified into simple or complicated disease. Due to the high prevalence of the disease, AA has been studied as a marker to assess the quality of care afforded to minority groups. Read More

Sisli Etfal Hastan Tip Bul 2022 28;56(1):62-69. Epub 2022 Mar 28.

Department of Ortopedics and Traumatology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences Turkey, Istanbul, Turkey.

Objectives: The pandemic of coronavirus disease 2019 (COVID-19) is still effective all over the world. Compared to adults, data on pediatric patients are limited. In this study, we aimed to retrospectively examine the demographic, clinical, and laboratory characteristics of pediatric patients who were followed up with the diagnosis of COVID-19 in the first 3 months of the pandemic in our hospital. Read More

Case Rep Womens Health 2022 Apr 25;34:e00412. Epub 2022 Apr 25.

Northern Health, 185 Cooper St, Epping, VIC 3076, Australia.

Background: Fallopian tube torsion is a rare finding in women presenting with abdominal pain, and it is exceedingly rare for it to be associated with concomitant appendicitis. The clinical presentation of isolated fallopian tube torsion can be a diagnostic problem because there are no specific clinical features. Early consideration of the diagnosis and prompt surgical management are required, as this can help to preserve the fallopian tube. Read More

Asian J Surg 2022 May 3. Epub 2022 May 3.

Gastroenterology Center, Suining Central Hospital, Sichuan, China.

Surg Today 2022 May 5. Epub 2022 May 5.

Faculty of Medicine, Department of Pediatric Surgery, Hacettepe University, Ankara, Turkey.

Purpose: To evaluate the management of children with severe gastrointestinal symptoms during the disease course of COVID-19 and multisystem inflammatory syndrome (MIS-C).

Methods: After ethical approval, we reviewed the medical records, retrospectively, of children with COVID-19 or MIS-C requiring surgical consultation for severe gastrointestinal symptoms.

Results: The subjects comprised 15 children, 13 with MIS-C and 2 with COVID-19. Read More

An Acad Bras Cienc 2022 2;94(2):e20201947. Epub 2022 May 2.

Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of General Surgery, Zuhuratbaba Neighborhood, Tevfik Saglam Road, Number 11, 34147, Bakirkoy, Istanbul, Turkey.

The diagnostic role of serum cytokines depends on the etiology and pathogenesis of acute appendicitis but the clinical significance of these cytokines in the differential diagnosis of complicated acute appendicitis remains unclear. To investigate the prediction of progression and diagnostic values of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha in complicated acute appendicitis. This study was conducted in 100 patients with a definitive diagnosis of acute appendicitis and 20 individuals assigned for the control group. Read More

Am J Emerg Med 2022 Apr 27. Epub 2022 Apr 27.

Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey. Electronic address:

BMJ Open 2022 May 2;12(5):e057793. Epub 2022 May 2.

Department of Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

Introduction: Emerging evidence has shown that an antibiotic first strategy is a viable treatment option for uncomplicated acute appendicitis (AA). Although there has recently been an interest and increase in the use of antibiotics as the primary strategy for treating uncomplicated AA, there is no consensus regarding the optimum antibiotic regimen. In particular, the long-term outcomes of different antibiotic regimens, such as the recurrence rate, still lack evidence. Read More

Cureus 2022 Apr 26;14(4):e24512. Epub 2022 Apr 26.

Anesthesia and Resuscitation Center, Bach Mai Hospital, Hanoi, VNM.

Background Single-incision laparoscopic appendectomy (SILA) has recently emerged as a promising alternative for the management of acute appendicitis. This study aimed to compare the surgical outcomes of the SILA with those of three laparoscopic appendectomies (TLA) procedures using the existing equipment, the 10-mm laparoscope, and the surgical-glove port method. Methodology Between February 2021 and February 2022, this single-center retrospective study examined 68 patients who underwent laparoscopic appendectomy by a single surgeon. Read More

Ann Med Surg (Lond) 2022 Apr 28;76:103535. Epub 2022 Mar 28.

Sina Hospital, Department of Surgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Introduction And Importance: Appendicitis is a common cause of acute abdomen in children. Due to its distinct clinical manifestations, often, its diagnosis is not very challenging. At younger age cases with atypical manifestations of appendicitis have been reported in the literature. Read More

Ann Med Surg (Lond) 2022 Apr 1;76:103524. Epub 2022 Apr 1.

Department of Internal Medicine, Chandka Medical College, Larkana, Pakistan.

Introduction: It is important to promptly assess the severity of appendicitis since late diagnosis can proceed towards perforation, peritonitis and sepsis. The main objective of this study is to decipher the ability of CRP, TLC and neutrophils in acute appendicitis to predict complications and perforation in pediatric age group.

Methods: This cohort study was conducted in the Pediatric Surgery Department of Liaquat National Hospital, Karachi. Read More

Case Rep Obstet Gynecol 2022 21;2022:1249676. Epub 2022 Apr 21.

Department of Obstetrics and Gynecology, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

Acute abdomen in pregnancy represents a diagnostic and therapeutic challenge, despite the current advances in modern medicine, since the typical symptoms and altered laboratory parameters mimic normal pregnancy. Acute appendicitis is the most common nonobstetric surgical emergency during pregnancy, with an incidence of 1 per 500-2000 pregnancies. Delayed diagnosis and reluctance to operate on a pregnant woman predispose to adverse maternal and fetal outcomes. Read More

Front Public Health 2022 15;10:889793. Epub 2022 Apr 15.

Department of Epidemiology and Biostatistics, Wuhan University School of Public Health, Wuhan, China.

Objective: Infectious etiology of acute appendicitis is a current hot topic. The most of study on appendicitis came from sporadic patients and focused on clinical treatment rather than control and prevention of appendicitis in the population. The present study aims to investigate the epidemiological features of cluster of acute appendicitis, risk factors, and evaluate effectiveness of control and prevention in population. Read More

J Pediatr Surg 2022 Apr 2. Epub 2022 Apr 2.

University Surgery Unit, Faculty of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK; Department of Paediatric Surgery and Urology, Southampton Children's Hospital, Southampton, UK. Electronic address:

Aim: To report the impact of the SARS-CoV-2 pandemic on management and outcomes of paediatric appendicitis in the UK and Ireland.

Methods: Prospective, multicentre observational cohort study at general surgical and specialist paediatric surgical centres in the United Kingdom and Ireland from 1st April to 31st July 2020. Primary outcome was treatment strategy used for acute appendicitis. Read More

Clin Radiol 2022 Apr 8. Epub 2022 Apr 8.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Aim: To evaluate the change in diagnosis rates, disease severity at presentation, and treatment of acute appendicitis and diverticulitis during the COVID-19 shutdown.

Materials And Methods: Following institutional review board approval, 6,002 CT examinations performed at five hospitals for suspected acute appendicitis and/or diverticulitis over the 12 weeks preceding and following the shutdown were reviewed retrospectively. Semi-automated language analysis (SALA) of the report classified 3,676 CT examinations as negative. Read More

Abdom Radiol (NY) 2022 Apr 29. Epub 2022 Apr 29.

Medical Imaging Center, Department of Radiology, Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.

Objectives: To determine the proportions of abdominal US examinations during on-call hours that are negative and that contain an incidentaloma, and to explore temporal changes and determinants.

Methods: This study included 1615 US examinations that were done during on-call hours at a tertiary care center between 2005 and 2017.

Results: The total proportion of negative US examinations was 49. Read More