437,642 results match your criteria Apoptosis : an international journal on programmed cell death[Journal]


Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals.

J Leukoc Biol 2020 Jul 8. Epub 2020 Jul 8.

Center for Stem Cell Research and Application, Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Chengdu, China.

Antagonism of ROS signaling can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells. Alpha lipoic acid (ALA), a small antioxidant molecule, affects cell apoptosis by lowering the ROS level. In this study, we show that ALA promoted production of human pluripotent stem cells (hPSCs) derived hemogenic endothelial cells and hematopoietic stem/progenitor cells in vitro. Read More

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http://dx.doi.org/10.1002/JLB.1A0520-179RDOI Listing

Pilot study of a new online extracorporeal photopheresis system in patients with steroid refractory or dependent chronic graft vs host disease.

J Clin Apher 2020 Jul 8. Epub 2020 Jul 8.

Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Background: A new protocol has been developed on the Amicus Separator that enables the device to perform online extracorporeal photopheresis (ECP) procedures when used in conjunction with the Phelix photoactivation device and associated disposable kit. The objective of this study was to evaluate the safety and performance of the Amicus ECP System in adult subjects with steroid-refractory or dependent chronic graft vs host disease (cGVHD).

Study Design And Methods: Eight subjects with mild to severe cGVHD underwent 31 procedures. Read More

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http://dx.doi.org/10.1002/jca.21804DOI Listing

Anticancer pentamethinium salt is a potent photosensitizer inducing mitochondrial disintegration and apoptosis upon red light illumination.

J Photochem Photobiol B 2020 Jun 23;209:111939. Epub 2020 Jun 23.

RECAMO, Masaryk Memorial Cancer Institute, Žlutý kopec 7, 656 53 Brno, Czech Republic. Electronic address:

Despite progress in the development and application of novel therapeutic agents, cancer remains a major cause of death worldwide. Therefore, there is a need for new approaches to increase therapeutic options and efficiency. The metabolism of cancer cells differs from that of non-malignant cells and their mitochondria show altered activities that can be utilized as a target for drug development. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111939DOI Listing

Cirsilineol inhibits proliferation of lung squamous cell carcinoma by inducing ROS mediated apoptosis.

Food Chem Toxicol 2020 Jul 5:111550. Epub 2020 Jul 5.

Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226015, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, Uttar Pradesh, India. Electronic address:

Cirsilineol belonging to the flavones category have not been explored in detail for anti-proliferative potential, therefore selected for the investigation. Hence, the antiproliferative potential of cirsilineol has been established in NCIH-520 cells. Cirsilineol exhibited good binding-energy and inhibited the activity of ODC, CATD, DHFR, HYAL, LOX-5, and COX-2 up to 45. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111550DOI Listing

miR-655: a promising regulator with therapeutic potential.

Gene 2020 Jul 5:144932. Epub 2020 Jul 5.

Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, China. Electronic address:

miR-655 is a widely studied non-coding small RNA molecule. miR-655 is down-regulated in at least 15 cancers and up-regulated in acute myeloid leukemia (AML) and breast cancer (BC) cell lines. The expression level of miR-655 is closely related to the prognosis of cancer patients. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144932DOI Listing

Evaluating the role of microRNAs alterations in oral squamous cell carcinoma.

Gene 2020 Jul 5:144936. Epub 2020 Jul 5.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Oral squamous cell carcinoma (OSCC) accounts for nearly 90 percent of oral cavity malignancies and is one of the most widespread oral cancers in the world. The microRNAs (miRNAs or miRs) have an important role in cellular processes comprising cell cycle, differentiation, and also apoptosis. MiRNAs are also implicated in the progression of cancers, including OSCC, through a variety of signaling pathways. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144936DOI Listing

Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells.

Cell Rep 2020 Jul;32(1):107855

Division of Biology and Medicine, Department of Molecular Microbiology and Immunology, Brown University Alpert Medical School, Providence, RI 02912, USA. Electronic address:

The liver harbors two main innate lymphoid cell (ILC) populations: conventional NK (cNK) cells and tissue-resident NK (trNK) cells. Using the MCMV model of infection, we find that, in contrast to liver cNK cells, trNK cells initially undergo a contraction phase followed by a recovery phase to homeostatic levels. The contraction is MCMV independent because a similar phenotype is observed following poly(I:C)/CpG or α-GalCer injection. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107855DOI Listing

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.

Cell Rep 2020 Jul;32(1):107846

Institute of Molecular Health Sciences, ETH Zurich, Otto-Stern-Weg 7, HPL H36, 8093 Zürich, Switzerland; Medical Faculty, University of Zurich, Zurich, Switzerland. Electronic address:

The ability of pancreatic β-cells to respond to increased demands for insulin during metabolic stress critically depends on proper ribosome homeostasis and function. Excessive and long-lasting stimulation of insulin secretion can elicit endoplasmic reticulum (ER) stress, unfolded protein response, and β-cell apoptosis. Here we show that the diabetes susceptibility gene JAZF1 is a key transcriptional regulator of ribosome biogenesis, global protein, and insulin translation. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107846DOI Listing

Kinetic Heterogeneity of Cancer Cell Fractional Killing.

Cell Rep 2020 Jul;32(1):107845

Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address:

Lethal drugs can induce incomplete cell death in a population of cancer cells, a phenomenon referred to as fractional killing. Here, we show that high-throughput population-level time-lapse imaging can be used to quantify fractional killing in response to hundreds of different drug treatments in parallel. We find that stable intermediate levels of fractional killing are uncommon, with many drug treatments resulting in complete or near-complete eradication of all cells, if given enough time. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107845DOI Listing

The Possible Protective Effect of Colchicine against Liver Damage Induced by Renal Ischemia-Reperfusion Injury: Role of Nrf2 and NLRP3 inflammasome.

Can J Physiol Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Al-Azhar University, 68820, pharmacology and toxicology , nasr city-cairo , Cairo, Egypt ;

Background: Ischemia/reperfusion injury (IRI) induces an inflammatory response and production of ROS, which affects the organs remote to the sites of RIR. However, remote effects of RIR injury on the liver need further investigations. Renal injury associated with liver disease is a common clinical problem. Read More

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http://dx.doi.org/10.1139/cjpp-2020-0230DOI Listing

Overexpression of RRM2 is related to poor prognosis in oral squamous cell carcinoma.

Oral Dis 2020 Jul 8. Epub 2020 Jul 8.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei- MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Objectives: Ribonucleotide reductase M2 (RRM2) is a rate-limiting enzyme involved in DNA repair and synthesis. This study aims to investigate the expression level, clinicopathological significance and prognostic value of RRM2 in oral squamous cell carcinoma (OSCC).

Materials And Methods: Human OSCC tissue microarrays were used to detect the expression of RRM2, cancer stem cell (CSCs) markers CD44 and aldehyde dehydrogenase 1 (ALDH1), and the epithelial-mesenchymal transition (EMT) marker Slug. Read More

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http://dx.doi.org/10.1111/odi.13540DOI Listing

Syringic acid modulates molecular marker-involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA-induced oral squamous cell carcinoma in Syrian hamsters.

J Biochem Mol Toxicol 2020 Jul 8:e22574. Epub 2020 Jul 8.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, India.

Despite, different medicinal phyto compounds giving an inexhaustible variety of anticancer drugs, potent signalling mechanism of leads  the key successes of anticancer agent, anti-inflammatory, induction of apoptosis, and antiangiogenic. The current study was conducted to estimate the effect of syringic acid (SA) on tumor necrosis factor-α (TNF-α)-mediated nuclear factor-κB (NF-κB) signaling pathways, inducing apoptosis and angiogenic signaling pathways in a hamster model by preneoplastic stages, histological, immunohistochemistry and immunoblots analysis. Hamsters were given oral cancer by painting 0. Read More

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http://dx.doi.org/10.1002/jbt.22574DOI Listing

The Effect of Knockdown TIGAR on Apoptotic and Epithelial-Mesenchymal Markers Expression in Doxorubicin-Resistant Non-Small Cell Lung Cancer A549 Cell Line.

Chem Biodivers 2020 Jul 8. Epub 2020 Jul 8.

Institut biohimii imeni O V Palladina Nacional'na akademia nauk Ukraini, Department of Enzyme Chemistry, Leontovich 9 street, Kiyv, UKRAINE.

Resistance to chemotherapeutic drugs is a critical problem in cancer therapy, but the underlying mechanism has not been fully elucidated.   TP53-induced glycolysis regulatory phosphatase (TIGAR), an important glycolysis and apoptosis regulator, plays a crucial role in cancer cell survival by protecting cells against oxidative stress-induced apoptosis. In the present study, we investigated whether TIGAR is involved in epithelial-mesenchymal transition (EMT) in doxorubicin (DOX)-resistant human non-small cell lung cancer (NSCLC), A549/DOX cells. Read More

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http://dx.doi.org/10.1002/cbdv.202000441DOI Listing

P-cresyl sulfate causes mitochondrial hyperfusion in H9C2 cardiomyoblasts.

J Cell Mol Med 2020 Jul 8. Epub 2020 Jul 8.

Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Increased circulating level of uraemic solute p-cresyl sulphate (PCS) in patients with chronic kidney disease (CKD) is known to increase myocardial burden relevant to mitochondrial abnormalities. This study aimed at investigating mitochondrial response to PCS in H9C2 cardiomyoblasts. H9C2 cardiomyoblasts were treated with four different concentrations of PCS (3. Read More

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http://dx.doi.org/10.1111/jcmm.15303DOI Listing

Effects of thoracic nerve block on perioperative lung injury, immune function, and recovery after thoracic surgery.

Clin Transl Med 2020 Jul 8. Epub 2020 Jul 8.

Department of Anesthesiology and Perioperative Medicine, Center for Clinical Single Cell Biomedicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, P. R. China.

Background: To investigate the effects of thoracic nerve block on perioperative lung injury, immune function, and recovery after thoracic surgery METHODS: A total of 120 patients with lung cancer were randomly allocated into three groups: general anesthesia group (GAL group), thoracic paravertebral nerve block (TPVB) combined with general anesthesia (TPL group), and TPVB (with paravertebral dexmedetomidine) combined with general anesthesia group (TDL group); 120 patients with esophageal cancer were randomly allocated into three groups: general anesthesia group (GAE group), TPVB combined with general anesthesia group (TPE group), and thoracic epidural block combined with general anesthesia group (TEE group). Lung injury and immune function were evaluated. Hemodynamic changes, early recovery in post-anesthesia care unit, pain, 6-min walking test (6MWT), drug consumption, and life quality were also observed. Read More

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http://dx.doi.org/10.1002/ctm2.38DOI Listing

Overexpression of ER Protein Processing and Apoptosis Regulator Genes in HEK 293 Cells Improves Gene Therapy Vectors Production.

Biotechnol J 2020 Jul 8:e1900562. Epub 2020 Jul 8.

iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, Oeiras, Portugal, 2781-901.

Gammaretroviral and lentiviral vectors (γ-RV and LV) are among the most used vectors in gene therapy clinical trials and market approved products. Currently, HEK 293 cells, the manufacture platform of choice for these vectors, provide low transducing particle yields, challenging their therapeutic applications and commercialization. This work studied metabolic pathways, focusing on endoplasmic reticulum (ER) protein processing and anti-apoptotic mechanisms, influencing vector productivity in HEK 293 cell substrates. Read More

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http://dx.doi.org/10.1002/biot.201900562DOI Listing

Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure in neonatal rats.

Synapse 2020 Jul 8:e22181. Epub 2020 Jul 8.

Department of Anesthesiology, the Second Hospital, Cheeloo College of Medicine, Shandong University, No.247 Beiyuan Road, Jinan, 250033, Shandong, China.

Ketamine is a frequently used anesthetic in pediatric patients that can cause cognitive impairment. Genistein, a bioactive component of soy products, has been shown to suppress neuronal death through regulating the expression of apoptosis related genes. In this study, we hypothesized that genistein could alleviate ketamine induced cognitive impairment by ameliorating hippocampal neuronal loss and tested this hypothesis in rats. Read More

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http://dx.doi.org/10.1002/syn.22181DOI Listing

Peroxiredoxin 2 deficiency reduces white adipogenesis due to the excessive ROS generation.

Cell Biol Int 2020 Jul 8. Epub 2020 Jul 8.

School of Life Sciences, BK21 Plus KNU Creative Bioresearch Group, Kyungpook National University, Daegu, Republic of Korea.

Reactive oxygen species (ROS) act as signaling molecules to regulate various cell functions. Numerous studies have demonstrated ROS to be essential for the differentiation of adipocytes. Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes in mammalian cells. Read More

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http://dx.doi.org/10.1002/cbin.11417DOI Listing

Thioredoxin interacting protein (TXNIP) acts as a tumor suppressor in human prostate cancer.

Cell Biol Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Urology, Central Theater Command General Hospital of The Chinese People's Liberation Army, Wuhan, Hubei, 430070, P.R. China.

Prostate cancer (PCa) is one of the most common malignant tumors in the world. Thioredoxin interacting protein (TXNIP) is down-regulated in a variety of human tumors and plays an important role in tumor suppression. However, the expression level and biological functions of TXNIP in PCa have not been identified yet. Read More

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http://dx.doi.org/10.1002/cbin.11418DOI Listing

The Prolyl Hydroxylase Inhibitor Dimethyl Oxalyl Glycine Decreases Early Gastrointestinal GVHD in Experimental Allogeneic Hematopoietic Cell Transplantation.

Transplantation 2020 Jun 29. Epub 2020 Jun 29.

Department of Internal Medicine, Division of Hematology & Blood and Marrow Transplantation, Markey Cancer Center, University of Kentucky, Lexington, KY.

Background: Prolyl hydroxylase inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1 alpha (HIF-1α) and affect signaling cascades of inflammation and cell death. Their beneficial use in experimental models of ulcerative colitis and lung allograft rejection led us to test the effect of the PHI dimethyl oxalyl glycine (DMOG) in the pathophysiology of graft versus host disease (GVHD).

Methods: Acute GVHD was induced in lethally irradiated BALB/c mice. Read More

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http://dx.doi.org/10.1097/TP.0000000000003383DOI Listing

Calcium channel blockers in pancreatic cancer: increased overall survival in a retrospective cohort study.

Anticancer Drugs 2020 Jul 3. Epub 2020 Jul 3.

Department of HPB and Transplant Surgery, Freeman Hospital, High Heaton.

Repurposing commonly prescribed noncancer medications for use in oncology has substantial advantages over de-novo development of anticancer drugs. Calcium signalling has been implicated in many of the hallmarks of cancer. Previous in-vitro and in-vivo studies have shown that calcium channel blockers (CCBs) are able to promote apoptosis, inhibit proliferation and prevent invasion and metastasis in a variety of cancer types. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000947DOI Listing

Cytotoxic mechanisms of primin, a natural quinone isolated from Eugenia hiemalis, on hematological cancer cell lines.

Anticancer Drugs 2020 Jul 3. Epub 2020 Jul 3.

Laboratory of Experimental Oncology and Hemopathies, Department of Clinical Analysis, Federal University of Santa Catarina.

Considering the high morbidity and mortality rates associated with hematological malignancies and the frequent development of drug resistance by these diseases, the search for new cytotoxic agents is an urgent necessity. The new compounds should present higher efficiency and specificity in inducing tumor cell death, be easily administered and have little or negligible adverse effects. Quinones have been reported in the literature by their several pharmacological properties, including antitumor activity, thus, the aim of this study was to investigate the cytotoxic effect of primin, a natural quinone, on hematological malignancies cell lines. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000937DOI Listing

Apoptosis of lung cells regulated by mitochondrial signal pathway in crotonaldehyde-induced lung injury.

Environ Toxicol 2020 Jul 8. Epub 2020 Jul 8.

School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.

Crotonaldehyde, a highly toxic α, β-unsaturated aldehyde, is a ubiquitous hazardous pollutant. Because of its extreme toxicity and ubiquity in all types of smoke, most current research focuses on the lung toxicity of such air pollutants. However, the specific mechanism of pulmonary toxicity caused by crotonaldehyde remains unclear, especially after long-term exposure to crotonaldehyde at low dose. Read More

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http://dx.doi.org/10.1002/tox.22991DOI Listing

Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer.

J Mater Chem B 2020 Jul 8. Epub 2020 Jul 8.

The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China. and Key Laboratory of Oral Biomedical Research of Zhejiang Province, School of Stomatology, Zhejiang University, Hangzhou, People's Republic of China.

The combination of different modalities greatly enhances the anticancer efficacy of each treatment by combining their merits, showing promising potential in clinical translation. Herein, we fabricated cancer cell membrane-coated gold nanorods (GNR@Mem) possessing excellent photothermal transfer ability in the second near-infrared window and radiosensitizing ability under X-ray irradiation. The cancer cell membrane coating endowed the nanomedicine with stability in the physiological environment and selective homotypic targeting to specific cancer cells in vitro. Read More

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http://dx.doi.org/10.1039/d0tb01063dDOI Listing

Effects of β-HgS on cell viability and intracellular oxidative stress in PC-12 cells.

Metallomics 2020 Jul 8. Epub 2020 Jul 8.

Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, CAS, 23 xin'ning road, Xining 810008, China.

Traditional Tibetan medicines containing β-HgS have been used to treat chronic ailments for thousands of years. However, there has recently been speculation regarding the safety of these medicines due to their high mercury content. Although the toxic effect of β-HgS has been previously investigated in vivo, the mechanism underlying the toxicity of this compound remains unclear. Read More

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http://dx.doi.org/10.1039/d0mt00088dDOI Listing

Characterization of as a Novel Tumor Suppressor of Lung Adenocarcinoma.

Mol Cells 2020 Jul 8. Epub 2020 Jul 8.

Department of Life Science, Ewha Womans University, Seoul 03760, Korea.

In this study, we describe a novel function of (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and down-regulation of was shown to be strongly correlated with increased mortality among LUAD patients. Interestingly, expression was enhanced by suppression of , and ectopic expression of in turn inhibited -mediated anchorage independent growth of NIH3T3 cells. Read More

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http://dx.doi.org/10.14348/molcells.2020.0075DOI Listing

BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL-induced DNA damage and endothelial apoptosis.

Physiol Rep 2020 Jul;8(13):e14481

Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Mutations in the tumor suppressor gene BRCA2 (BReast CAncer susceptibility gene 2) predispose carriers to breast, ovarian, and other cancers. In response to DNA damage, BRCA2 participates in homology-directed DNA damage repair to maintain genome stability. Genome-wide association studies have identified an association between BRCA2 single nucleotide polymorphisms and plasma-lipid levels and lipid deregulation in humans. Read More

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http://dx.doi.org/10.14814/phy2.14481DOI Listing

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview.

Obes Rev 2020 Jul 7. Epub 2020 Jul 7.

Faculty of Health Sciences, Department of Experimental Immunology, Medical University of Lodz, Lodz, Poland.

Adipokines are predominantly known to play a vital role in the control of food intake, energy homeostasis and regulation of glucose and lipid metabolism. However, evidence supporting the concept of their extensive involvement in immune system defence mechanisms and inflammatory processes continues to grow. Some of the adipokines, that is, leptin and resistin, have been recognized to exhibit mainly pro-inflammatory properties, whereas others such as visfatin, chemerin, apelin and vaspin have been found to exert regulatory effects. Read More

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http://dx.doi.org/10.1111/obr.13055DOI Listing

Use of proteomics to identify biomarkers associated with chronic kidney disease and long-term outcomes in patients with myocardial infarction.

J Intern Med 2020 Jul 8. Epub 2020 Jul 8.

From the, Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

Background: Patients with chronic kidney disease (CKD) have poor outcomes following myocardial infarction (MI). We performed an untargeted examination of 175 biomarkers to identify those with the strongest association with CKD and to examine the association of those biomarkers with long-term outcomes.

Methods: A total of 175 different biomarkers from MI patients enrolled in the Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) registry were analysed either by a multiple reaction monitoring mass spectrometry assay or by a multiplex assay (proximity extension assay). Read More

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http://dx.doi.org/10.1111/joim.13116DOI Listing

Cantharidin-induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro.

J Appl Toxicol 2020 Jul 8. Epub 2020 Jul 8.

Basic Medical School, Zunyi Medical University, Zunyi, China.

Cantharidin (CTD), an important active compound derived from the traditional Chinese medicine Mylabris (also called Banmao), has been used in the treatment of diseases such as tumors and dermatosis. However, Mylabris has been shown to induce hepatotoxicity in clinical practice and animal experiments, limiting its use. Further, a detailed mechanism underlying CTD-induced hepatotoxicity has not been determined. Read More

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http://dx.doi.org/10.1002/jat.4022DOI Listing
July 2020
2.982 Impact Factor

LINC-PINT suppresses tumour cell proliferation, migration and invasion through targeting miR-374a-5p in ovarian cancer.

Cell Biochem Funct 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology, Heze Municipal Hospital, Heze, China.

LncRNA LINC-PINT acts as an important regulator in the development of many cancers. The current study aimed to explore the role of LINC-PINT in the progression of ovarian cancer (OC). LINC-PINT expression level in different FIGO stages of OC and its adjacent tissues, normal HOSE and OC cell lines (A2780, SKOV3, OVCAR3 and HO-8910) was determined by qRT-PCR. Read More

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http://dx.doi.org/10.1002/cbf.3565DOI Listing

Investigation of the role of quercetin as a heat shock protein inhibitor on apoptosis in human breast cancer cells.

Mol Biol Rep 2020 Jul 8. Epub 2020 Jul 8.

Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Vezneciler, 34134, Istanbul, Turkey.

High expression of heat shock proteins (Hsp) in breast cancer has been closely associated with tumor cell proliferation and thus a poor clinical outcome. Quercetin, a good Hsp inhibitor as a dietary flavonoid, possesses anticarcinogenic properties. Although there are many studies on the effects of quercetin on Hsp levels in human breast cancer cells, research on elucidation of its molecular mechanism continues. Read More

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http://dx.doi.org/10.1007/s11033-020-05641-xDOI Listing

Silybum marianum (milk thistle) improves vancomycin induced nephrotoxicity by downregulating apoptosis.

Mol Biol Rep 2020 Jul 7. Epub 2020 Jul 7.

Department of Zoology, GC University, Lahore, Pakistan.

Increased use of vancomycin for treating infections, and the associated risk of causing nephrotoxicity lead to the present study. The antioxidant and anti-apoptotic potential of Silybum marianum is used along with vancomycin to reduce adverse effects on the kidney. Vero cells (monkey kidney cells) and mice were used to test S. Read More

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http://dx.doi.org/10.1007/s11033-020-05635-9DOI Listing

Interference with miR-210 Alleviated Renal Injury in Septic Rats by Inhibiting JAK-STAT Pathway.

Inflammation 2020 Jul 7. Epub 2020 Jul 7.

Department of Infection Disease, Children's Hospital of Nanjing Medical University, No.72, Guangzhou road, Gulou District, Nanjing, Jiangsu Province, 210000, China.

Pediatric sepsis has become the leading cause of death in pediatric intensive care units (PICU). The regulation of target genes may be the key to the treatment of pediatric sepsis. The expression of miR-210 in rat serum was detected by RT-qPCR. Read More

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http://dx.doi.org/10.1007/s10753-020-01283-0DOI Listing

Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis.

Metab Brain Dis 2020 Jul 7. Epub 2020 Jul 7.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Over the past few decades several attempts have been made to introduce a potential and promising therapy for Multiple sclerosis (MS). Calorie restriction (CR) is a dietary manipulation to reduce calorie intake which has been shown to improve neuroprotection and attenuate neurodegenerative disorders. Here, we evaluated the effect of 33% CR regimen for 4 weeks on the remyelination capacity of Cuprizone (CPZ) induced demyelination in a mouse model of MS. Read More

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http://dx.doi.org/10.1007/s11011-020-00597-0DOI Listing

The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis.

Apoptosis 2020 Jul 7. Epub 2020 Jul 7.

Department of Dermatology and Allergology, School of Medicine, Technical University of Munich, Biedersteinerstr. 29, 80802, München, Germany.

Costunolide, a natural sesquiterpene lactone, has multiple pharmacological activities such as neuroprotection or induction of apoptosis and eryptosis. However, the effects of costunolide on pro-survival factors and enzymes in human erythrocytes, e.g. Read More

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http://dx.doi.org/10.1007/s10495-020-01620-6DOI Listing

Hypoxia-inducible factor-1α in acute ischemic stroke: neuroprotection for better clinical outcome.

Heliyon 2020 Jun 28;6(6):e04286. Epub 2020 Jun 28.

Department of Biomedical Science Faculty of Medicine, Universitas Padjadjaran, Indonesia.

Background: Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor which maintains cellular homeostasis in response to hypoxia. It can trigger apoptosis while stimulating angiogenesis process and decrease neurological deficit after an ischemic stroke. Up until now, this protein complex has not been widely investigated especially in stroke patient. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327744PMC

The protective effect of astaxanthin on the ganglion cell complex in glutamate/aspartate transporter deficient mice, a model of normal tension glaucoma, analyzed by spectral domain-optical coherence tomography.

Biochem Biophys Rep 2020 Sep 29;23:100777. Epub 2020 Jun 29.

Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan.

Astaxanthin (AST), a natural marine carotenoid, possess a wide variety of biological functions. In particular, as a strong antioxidant, AST effectively scavenges oxygen free radicals and reduces oxidative stress. In addition, recent studies have suggested that AST attenuates glutamate-induced apoptosis and cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.bbrep.2020.100777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330488PMC
September 2020

Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.

Sci Adv 2020 Jun 24;6(26):eaay9778. Epub 2020 Jun 24.

Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

Cells respond to oxidative stress by inducing intracellular signaling, including stress-activated p38 and JNK MAPK (SAPK) pathways, but the underlying mechanisms remain unclear. Here, we report that the MAP three kinase 1 (MTK1) SAPK kinase kinase (SAPKKK) functions as an oxidative-stress sensor that perceives the cellular redox state and transduces it into SAPK signaling. Following oxidative stress, MTK1 is rapidly oxidized and gradually reduced at evolutionarily conserved cysteine residues. Read More

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http://dx.doi.org/10.1126/sciadv.aay9778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314524PMC

LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression.

Mol Ther Oncolytics 2020 Jun 23;17:547-561. Epub 2020 May 23.

Department of Clinical Laboratory, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Hepatocellular carcinoma (HCC) is a common malignant tumor. LukS-PV is the S component of Panton-Valetine leukocidin (PVL), which is secreted by . This study investigated the effects of LukS-PV on the proliferation, apoptosis, and cell-cycle progression of HCC cells and the mechanisms of its activity. Read More

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http://dx.doi.org/10.1016/j.omto.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321822PMC

Mechanisms of Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers.

Front Vet Sci 2020 19;7:340. Epub 2020 Jun 19.

USDA-ARS, Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, Orient, NY, United States.

Foot-and-mouth disease virus (FMDV) causes persistent infection of nasopharyngeal epithelial cells in ~50% of infected ruminants. The mechanisms involved are not clear. This study provides a continued investigation of differentially expressed genes (DEG) identified in a previously published transcriptomic study analyzing micro-dissected epithelial samples from FMDV carriers and non-carriers. Read More

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http://dx.doi.org/10.3389/fvets.2020.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318773PMC

Corrigendum: Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway.

Front Cell Dev Biol 2020 19;8:462. Epub 2020 Jun 19.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

[This corrects the article DOI: 10.3389/fcell.2020. Read More

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http://dx.doi.org/10.3389/fcell.2020.00462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319017PMC

A Gold Nanoparticle Bouquet held on plasma membrane: An ultrasensitive dark-field imaging approach for Cancer Cell Analysis.

Nanotheranostics 2020 20;4(4):201-209. Epub 2020 Jun 20.

Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, PR China.

p53 is suppressing tumor protein correlated with the cell cycle factors and apoptosis. Here, a gold nanoparticle bouquet is designed for an ultrasensitive dark-field imaging approach for cancer cell analysis. AuNP60/APBA is functionalized by a gold nanoparticle bouquet-plasmonic 60 nm gold nanoparticles. Read More

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http://dx.doi.org/10.7150/ntno.41639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332797PMC

Curcumin prevents chronic intermittent hypoxia-induced myocardial injury.

Ther Adv Chronic Dis 2020 24;11:2040622320922104. Epub 2020 Jun 24.

University Grenoble Alpes, Grenoble, France INSERM, U1042, Grenoble, France.

Background: Chronic intermittent hypoxia (IH), the hallmark feature of obstructive sleep apnoea syndrome, contributes to infarct size enhancement after myocardial ischemia-reperfusion (I/R). Curcumin (Curc), the natural pigment of , has been demonstrated to be beneficial in the context of myocardial injury. In this study, we assessed the effects of Curc on the maladaptive cardiac response to IH, and particularly on IH-induced hypoxia inducible factor-1 (HIF-1) expression, oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis. Read More

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http://dx.doi.org/10.1177/2040622320922104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315663PMC

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit.

Oncotarget 2020 Jun 23;11(25):2387-2403. Epub 2020 Jun 23.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

The 90 kDa Ribosomal S6 Kinase (RSK) drives cell proliferation and survival in cancers, although its oncogenic mechanism has not been well characterized. Phosphorylated level of RSK (T573) was increased in acute myeloid leukemia (AML) patients and associated with poor survival. To examine the role of RSK in AML, we analyzed apoptosis and the cell cycle profile following treatment with BI-D1870, a potent inhibitor of RSK. Read More

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http://dx.doi.org/10.18632/oncotarget.27630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321696PMC

HTNV Sensitizes Host Toward TRAIL-Mediated Apoptosis-A Pivotal Anti-hantaviral Role of TRAIL.

Front Immunol 2020 19;11:1072. Epub 2020 Jun 19.

State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy & Immunology, School of Basic Medical Sciences, Institute of Medical Virology, Wuhan University, Wuhan, China.

Hantaviruses can cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and have led to public health threat in China. The pathogenesis of HFRS is complex and involves capillary leakage due to the infection of vascular endothelial cells. Accumulating evidence has demonstrated that hantavirus can induce apoptosis in many cells, but the mechanism remains unclear. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317014PMC

Ceramides in Adipose Tissue.

Front Endocrinol (Lausanne) 2020 19;11:407. Epub 2020 Jun 19.

Department of Nutrition and Integrative Physiology, The Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT, United States.

Adipose tissue is a key nutrient-sensing depot that regulates excess energy storage and consumption. Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. The presence of various types of adipocytes (white, brown, and beige) characterized by the number/size of lipid droplets, mitochondrial density, and thermogenic capacity, further highlights how intricate is the communication of these cell-types with other metabolic tissues to sense nutrients. Read More

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http://dx.doi.org/10.3389/fendo.2020.00407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316884PMC

Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells.

Front Pharmacol 2020 18;11:906. Epub 2020 Jun 18.

Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, China.

studies had shown that C-Phycocyanin (C-PC) inhibited cervical cancer HeLa cells growth. We constructed C-PC/CMC-CD55sp nanospheres using C-PC, Carboxymethyl Chitosan (CMC), and CD55 ligand peptide (CD55sp) to allow for targeted antitumor effects against HeLa cells and . The characteristics of the nanospheres were determined using FTIR, electron microscopy, and laser particle size analysis. Read More

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http://dx.doi.org/10.3389/fphar.2020.00906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319041PMC

MiR-1587 Regulates DNA Damage Repair and the Radiosensitivity of CRC Cells via Targeting LIG4.

Dose Response 2020 Apr-Jun;18(2):1559325820936906. Epub 2020 Jun 24.

Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.

DNA is subject to a range of endogenous and exogenous insults that can impair DNA replication and lead to DNA double-strand breaks (DSBs). The repair capacity of cancer cells mediates their radiosensitivity, but the roles of miR-1587 during radiation resistance are poorly characterized. In this study, we explored whether miR-1587 regulates the growth and radiosensitivity of colorectal cancer (CRC) cells through its ability to regulate DNA Ligase4 (LIG4). Read More

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http://dx.doi.org/10.1177/1559325820936906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315685PMC

Pyrophen Isolated from the Endophytic Fungus Strain KARSV04 Synergizes the Effect of Doxorubicin in Killing MCF7 but not T47D Cells.

Turk J Pharm Sci 2020 Jun 22;17(3):280-284. Epub 2020 Jun 22.

Universitas Gadjah Mada Faculty of Pharmacy, Department of Pharmaceutical Biology, Yogyakarta, Indonesia.

Objectives: Pyrophen, an amino acid-pyrone derivative isolated from strain KARSV04 has been reported to have an anticancer effect on T47D cells by inhibiting the growth of cells and modulating the cell cycle in the S phase. In the present study, the effect of pyrophen in doxorubicin (Dox) chemotherapy in an model of breast cancers was studied.

Materials And Methods: The cytotoxicity of pyrophen and Dox separately and in combination were evaluated in T47D and MCF-7 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2019.30633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336043PMC