2,360 results match your criteria Apoptosis[Journal]


Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent.

Apoptosis 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia.

Genotoxic anti-cancer therapies such as chemotherapy and radiotherapy can contribute to an increase in second malignancies in cancer survivors due to their oncogenic effects on non-cancerous cells. Inhibition of histone deacetylase (HDAC) proteins or the proteasome differ from chemotherapy in that they eliminate cancer cells by regulating gene expression or cellular protein equilibrium, respectively. As members of these drug classes have been approved for clinical use in recent times, we investigated whether these two drug classes exhibit similar mutagenic capabilities as chemotherapy. Read More

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http://dx.doi.org/10.1007/s10495-019-01543-xDOI Listing

17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAF inhibitors in melanoma cells of different genetic subtypes.

Apoptosis 2019 Apr 15. Epub 2019 Apr 15.

Department of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland.

Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17-aminogeldanamycin more potently activated caspase-3/7 in BRAF melanoma cells than geldanamycin, another inhibitor of heat shock protein 90 (HSP90). 17-aminogeldanamycin alleviated self-triggered compensatory increase in HSP70 mRNA level and induced endoplasmic reticulum (ER) stress, which was followed by selective diminution of cytoprotective IRE1α-XBP1s pathway activity of unfolded protein response (UPR), inhibition of ERK1/2 activity and induction of apoptosis. Read More

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http://dx.doi.org/10.1007/s10495-019-01542-yDOI Listing

Matrix metalloproteinase 9 induces keratinocyte apoptosis through FasL/Fas pathway in diabetic wound.

Apoptosis 2019 Apr 4. Epub 2019 Apr 4.

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Guangdong, China.

Apoptosis is a mechanism to remove unwanted cells in the tissue. In diabetic wound, which is characterized by delayed healing process, excessive apoptosis is documented and plays a crucial role. Matrix metalloproteinase 9 (MMP9), which is elevated in non-healed diabetic wound, is necessary for healing process but its abnormality resulted in a delayed healing. Read More

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http://dx.doi.org/10.1007/s10495-019-01536-wDOI Listing
April 2019
3.685 Impact Factor

Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer cells.

Apoptosis 2019 Apr 2. Epub 2019 Apr 2.

Laboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitarios s/n Nuevo Campus Universitario, C. P. 31125, Chihuahua, Mexico.

Breast cancer is the most frequently diagnosed cancer among women worldwide. Here, recombinant human lactoferrin (rhLf) expressed in Pichia pastoris was tested for its potential cytotoxic activity on a panel of six human breast cancer cell lines. The rhLf cytotoxic effect was determined via a live-cell HTS imaging assay. Read More

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http://dx.doi.org/10.1007/s10495-019-01539-7DOI Listing
April 2019
2 Reads

Potential role of anastasis in cancer initiation and progression.

Apoptosis 2019 Apr 1. Epub 2019 Apr 1.

Regenerative Medicine Laboratory, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.

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http://dx.doi.org/10.1007/s10495-019-01538-8DOI Listing
April 2019
1 Read

Calreticulin in phagocytosis and cancer: opposite roles in immune response outcomes.

Apoptosis 2019 Mar 30. Epub 2019 Mar 30.

Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Calreticulin (CRT) is a pleiotropic and highly conserved molecule that is mainly localized in the endoplasmic reticulum. Recently, CRT has gained special interest for its functions outside the endoplasmic reticulum where it has immunomodulatory properties. CRT translocation to the cell membrane serves as an "eat me" signal and promotes efferocytosis of apoptotic cells and cancer cell removal with completely opposite outcomes. Read More

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http://dx.doi.org/10.1007/s10495-019-01532-0DOI Listing
March 2019
1 Read

Correction to: Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway.

Apoptosis 2019 Mar 28. Epub 2019 Mar 28.

Department of Biotechnology and Dr. B. C. Guha Centre for Genetic Engineering and Biotechnology, University of Calcutta, 35 Ballygunge Circular Road, Ballygunge, Kolkata, West Bengal, 700 019, India.

The original version of this article unfortunately contained an error in acknowledgment text. The authors would like to include a statement: "Moumita Dasgupta is supported by Junior Research Fellowship from University Grant Commission, India." in acknowledgment section. Read More

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http://dx.doi.org/10.1007/s10495-019-01534-yDOI Listing
March 2019
3.685 Impact Factor

Effects of annexin A7 inhibitor-ABO on the expression and distribution of long noncoding RNA-CERNA1 in vascular endothelial cells apoptosis.

Apoptosis 2019 Mar 25. Epub 2019 Mar 25.

Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Qingdao, 266237, People's Republic of China.

More and more studies reported that diverse biological roles of long noncoding RNAs were usually dependent on their subcellular location. In our previous study, long noncoding RNA CERNA1 was identified both located in cytoplasm and nucleus of vascular endothelial cells (VECs). And CERNA1 in cytoplasm, which functioned as competitive endogenous RNA (ceRNA), alleviated the apoptosis of VECs. Read More

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http://dx.doi.org/10.1007/s10495-019-01537-9DOI Listing

Cell death rocks.

Apoptosis 2019 Mar 20. Epub 2019 Mar 20.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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http://dx.doi.org/10.1007/s10495-019-01516-0DOI Listing

Activator protein-1 and caspase 8 mediate p38α MAPK-dependent cardiomyocyte apoptosis induced by palmitic acid.

Apoptosis 2019 Mar 16. Epub 2019 Mar 16.

Phoenix VA Healthcare System, Phoenix, USA.

Lipoapoptosis of cardiomyocytes may underlie diabetic cardiomyopathy. Numerous forms of cardiomyopathies share a common end-pathway in which apoptotic loss of cardiomyocytes is mediated by p38α mitogen activated protein kinase (MAPK). Although we have previously shown that palmitic acid (PA), a saturated fatty acid (SFA) elevated in plasma of type 2 diabetes mellitus and morbid obesity, induces apoptosis in cardiomyocytes via p38α MAPK-dependent signaling, the downstream cascade events that cause cell death remain unknown. Read More

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http://dx.doi.org/10.1007/s10495-018-01510-yDOI Listing
March 2019
1 Read

Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.

Apoptosis 2019 Mar 16. Epub 2019 Mar 16.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.

Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56. Read More

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http://dx.doi.org/10.1007/s10495-019-01531-1DOI Listing
March 2019
3.685 Impact Factor

BDNF-mediated mitophagy alleviates high-glucose-induced brain microvascular endothelial cell injury.

Apoptosis 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, People's Republic of China.

Endothelial cell dysfunction and diabetic vascular complications are intrinsically linked. Although BDNF plays a protective role in cerebral microvascular complications caused by diabetes, the mechanisms of this activity are not fully clear. In this study, we investigated the role of BDNF in the hyperglycemic injury of BMECs and its associated intracellular signal transduction pathways. Read More

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http://dx.doi.org/10.1007/s10495-019-01535-xDOI Listing
March 2019
1 Read

Fibroblasts from patients with idiopathic pulmonary fibrosis are resistant to cisplatin-induced cell death via enhanced CK2-dependent XRCC1 activity.

Apoptosis 2019 Mar 8. Epub 2019 Mar 8.

Department of Medicine, University of Minnesota, 420 Delaware Street SE., Box 276, Minneapolis, MN, 55455, USA.

Idiopathic pulmonary fibrosis (IPF) is a deadly and progressive fibrotic lung disease, but the precise etiology remains elusive. IPF is characterized by the presence of apoptosis-resistant (myo)fibroblasts that relentlessly produce a collagen-rich extracellular matrix (ECM). Recent studies showed that an anti-cancer chemotherapy drug cisplatin is implicated in the development of pulmonary fibrosis, suggesting that the treatment of cancer patients with cisplatin may alter fibroblast viability. Read More

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http://dx.doi.org/10.1007/s10495-019-01529-9DOI Listing
March 2019
2 Reads

Inhibition of TNF-α-induced neuronal apoptosis by antidepressants acting through the lysophosphatidic acid receptor LPA.

Apoptosis 2019 Mar 6. Epub 2019 Mar 6.

Laboratory of Cellular and Molecular Pharmacology, Section of Neurosciences, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine considered to be implicated in the pathogenesis of major depressive disorder, is a critical regulator of neuronal cell fate. In the present study we found that TNF-α-induced apoptosis of HT22 hippocampal cells, a neuroblast-like cell line, was markedly attenuated by the antidepressants mianserin, mirtazapine and amitriptyline. The anti-apoptotic effect of the antidepressants was blocked by either pharmacological inhibition or gene silencing of the lysophosphatidic acid receptor LPA. Read More

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http://dx.doi.org/10.1007/s10495-019-01530-2DOI Listing

Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development.

Apoptosis 2019 Feb 22. Epub 2019 Feb 22.

Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, 150040, China.

Previous studies in several model organisms have revealed that members of the Forkhead (Fkh) transcription factor family have multiple functions. Drosophila Jumeau (Jumu), a member of this family, participates in cardiogenesis, hematopoiesis and immune system homeostasis. Here, we show that loss of jumu function positively regulates or triggers apoptosis via a JNK-dependent pathway in wing development. Read More

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http://dx.doi.org/10.1007/s10495-019-01527-xDOI Listing
February 2019

Simultaneous polychromatic flow cytometric detection of multiple forms of regulated cell death.

Apoptosis 2019 Feb 20. Epub 2019 Feb 20.

Flow Cytometry Core Facility, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, 4 Newark Street, London, E1 2AT, UK.

Currently the study of Regulated Cell Death (RCD) processes is limited to the use of lysed cell populations for Western blot analysis of each separate RCD process. We have previously shown that intracellular antigen flow cytometric analysis of RIP3, Caspase-3 and cell viability dye allowed the determination of levels of apoptosis (Caspase-3/RIP3), necroptosis (RIP3/Caspase-3) and RIP1-dependent apoptosis (Caspase-3/RIP3) in a single Jurkat cell population. The addition of more intracellular markers allows the determination of the incidence of parthanatos (PARP), DNA Damage Response (DDR, H2AX), H2AX hyper-activation of PARP (H2AX/PARP) autophagy (LC3B) and ER stress (PERK), thus allowing the identification of 124 sub-populations both within live and dead cell populations. Read More

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http://link.springer.com/10.1007/s10495-019-01528-w
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http://dx.doi.org/10.1007/s10495-019-01528-wDOI Listing
February 2019
3 Reads

The neuroprotective action of 3,3'-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling.

Apoptosis 2019 Feb 18. Epub 2019 Feb 18.

Department of Experimental Neuroendocrinology, Laboratory of Molecular Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna Street 12, 31-343, Krakow, Poland.

There are no studies examining the effects of 3,3'-diindolylmethane (DIM) in neuronal cells subjected to ischemia. Little is also known about the roles of apoptosis and autophagy as well as AhR and ERα signaling and HDACs in DIM action. We demonstrated for the first time the strong neuroprotective capacity of DIM in mouse primary hippocampal cell cultures exposed to ischemia at early and later stages of neuronal development. Read More

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http://dx.doi.org/10.1007/s10495-019-01522-2DOI Listing
February 2019

Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway.

Apoptosis 2019 Feb 14. Epub 2019 Feb 14.

Department of Biotechnology and Dr. B. C. Guha Centre for Genetic Engineering and Biotechnology, University of Calcutta, 35 Ballygunge Circular Road, Ballygunge, Kolkata, West Bengal, 700 019, India.

Paclitaxel is one of the most commonly used drugs for the treatment of nonsmall cell lung cancer (NSCLC). However acquired resistance to paclitaxel, epithelial to mesenchymal transition and cancer stem cell formation are the major obstacles for successful chemotherapy with this drug. Some of the major reasons behind chemoresistance development include increased ability of the cancer cells to survive under stress conditions by autophagy, increased expression of drug efflux pumps, tubulin mutations etc. Read More

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http://dx.doi.org/10.1007/s10495-019-01526-yDOI Listing
February 2019
1 Read
3.685 Impact Factor

Minocycline promotes cardiomyocyte mitochondrial autophagy and cardiomyocyte autophagy to prevent sepsis-induced cardiac dysfunction by Akt/mTOR signaling.

Apoptosis 2019 Feb 12. Epub 2019 Feb 12.

Department of Anesthesiology and Critical Care Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.

Myocardial damage is responsible for the high mortality of sepsis. However, the underlying mechanism is not well understood. Cardiomyocyte autophagy alleviates the cardiac injury caused by myocardial infarction. Read More

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http://dx.doi.org/10.1007/s10495-019-01521-3DOI Listing
February 2019
2 Reads

Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts.

Apoptosis 2019 Feb 8. Epub 2019 Feb 8.

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Higashi 23 bancho 35-1, Towada, Aomori, 034-8628, Japan.

During the development of cardiac hypertrophy, glucose deprivation (GD) associated with coronary microvascular rarefaction is caused, leading to cardiomyocyte death. Phosphorylation (inactivation) of eukaryotic elongation factor 2 (eEF2) by eEF2 kinase (eEF2K) inhibits protein translation, a highly energy consuming process, which plays protective roles against nutrient deprivation-induced cell death. We previously showed that eEF2 phosphorylation was increased in isolated heart from several cardiac hypertrophy models. Read More

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http://dx.doi.org/10.1007/s10495-019-01525-zDOI Listing
February 2019
1 Read

Excess active P13K rescues huntingtin-mediated neuronal cell death but has no effect on axonal transport defects.

Apoptosis 2019 Feb 6. Epub 2019 Feb 6.

Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, 14260, US.

High levels of oxidative stress is detected in neurons affected by many neurodegenerative diseases, including huntington's disease. Many of these diseases also show neuronal cell death and axonal transport defects. While nuclear inclusions/accumulations likely cause cell death, we previously showed that cytoplasmic axonal accumulations can also contribute to neuronal death. Read More

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http://dx.doi.org/10.1007/s10495-019-01520-4DOI Listing
February 2019
5 Reads

Combination treatment of podophyllotoxin and rutin promotes mouse Lgr5 intestinal stem cells survival against lethal radiation injury through Wnt signaling.

Apoptosis 2019 Feb 6. Epub 2019 Feb 6.

Division of Radioprotective Drug Development and Research, Institute of Nuclear Medicine and Allied Sciences, Brig. S. K. Majumdar Marg, Timarpur, Delhi, 110054, India.

It has been well established that radiation-induced gastrointestinal injury is manifested through loss of intestinal crypt stem cells and disruption of the mucosal layers, resulting in diarrhoea, weight loss, electrolyte imbalance, infection and mortality. Podophyllotoxin and rutin in combination (G-003M) has been reported to regulate endogenous cellular antioxidant defense systems and inflammatory response. However, the mechanism by which G-003M ameliorates radiation-induced intestinal stem cell (ISC) injury remains unclear. Read More

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http://dx.doi.org/10.1007/s10495-019-01519-xDOI Listing
February 2019
1 Read

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation.

Apoptosis 2019 Feb 1. Epub 2019 Feb 1.

Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou, China.

Gasdermin E (GSDME) has an important role in inducing secondary necrosis/pyroptosis. Upon apoptotic stimulation, it can be cleaved by activated caspase-3 to generate its N-terminal fragment (GSDME-NT), which executes pyroptosis by perforating the plasma membrane. GSDME is expressed in many human lung cancers including A549 cells. Read More

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http://dx.doi.org/10.1007/s10495-019-01515-1DOI Listing
February 2019
1 Read

Genetic and epigenetic analysis of the BAX and BCL2 in the placenta of pregnant women complicated by preeclampsia.

Apoptosis 2019 Jan 30. Epub 2019 Jan 30.

Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

The current study examined the effects of BAX and BCL2 polymorphisms and methylation as well as mRNA expression on susceptibility to PE. After delivery, the placentas were collected from 92 women with PE, as well as 106 normotensive pregnant women. The BAX rs4645878 and BCL2 rs2279115 polymorphisms were genotyped by the PCR-RFLP method. Read More

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http://link.springer.com/10.1007/s10495-018-1501-8
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http://dx.doi.org/10.1007/s10495-018-1501-8DOI Listing
January 2019
10 Reads
3.685 Impact Factor

Methods for monitoring the progression of cell death, cell disassembly and cell clearance.

Apoptosis 2019 Jan 25. Epub 2019 Jan 25.

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.

Cell death through apoptosis, necrosis, necroptosis and pyroptosis, as well as the clearance of dead cells are crucial biological processes in the human body. Likewise, disassembly of dying cells during apoptosis to generate cell fragments known as apoptotic bodies may also play important roles in regulating cell clearance and intercellular communication. Recent advances in the field have led to the development of new experimental systems to identify cells at different stages of cell death, measure the levels of apoptotic cell disassembly, and monitor the cell clearance process using a range of in vitro, ex vivo and in vivo models. Read More

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http://dx.doi.org/10.1007/s10495-018-01511-xDOI Listing
January 2019

Protective effect of dihydromyricetin on hyperthermia-induced apoptosis in human myelomonocytic lymphoma cells.

Apoptosis 2019 Jan 25. Epub 2019 Jan 25.

Department of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Dihydromyricetin (DMY) is a traditional herbal medicine, with a wide range of biological activities. Extreme hyperthermia (HT) can suppress the immune system; thus, protection of the immune system is beneficial in heat-related diseases, including heatstroke. In our study, we revealed the protective effect of DMY against HT-induced apoptosis and analysed the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1007/s10495-019-01518-yDOI Listing
January 2019
1 Read

Targeting phosphatidylserine for radionuclide-based molecular imaging of apoptosis.

Apoptosis 2019 Jan 25. Epub 2019 Jan 25.

Department of Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.

One major characteristic of programmed cell death (apoptosis) results in the increased expression of phosphatidylserine (PS) on the outer membrane of dying cells. Consequently, PS represents an excellent target for non-invasive imaging of apoptosis by single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Annexin V is a 36 kDa protein which binds with high affinity to PS in the presence of Ca ions. Read More

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http://link.springer.com/10.1007/s10495-019-01523-1
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http://dx.doi.org/10.1007/s10495-019-01523-1DOI Listing
January 2019
7 Reads

NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis.

Apoptosis 2019 Jan 24. Epub 2019 Jan 24.

Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstr. 3a, 60528, Frankfurt, Germany.

Smac mimetics that deplete cellular inhibitor of apoptosis (cIAP) proteins have been shown to activate Nuclear Factor-kappa B (NF-κB). Here, we report that Smac mimetic-mediated activation of NF-κB contributes to the rescue of cancer cells from tunicamycin (TM)-triggered apoptosis. The prototypic Smac mimetic BV6 activates non-canonical and canonical NF-κB pathways, while TM has little effect on NF-κB signaling. Read More

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http://dx.doi.org/10.1007/s10495-018-1507-2DOI Listing
January 2019

Overexpression of augmenter of liver regeneration (ALR) mitigates the effect of HO-induced endoplasmic reticulum stress in renal tubule epithelial cells.

Apoptosis 2019 Jan 24. Epub 2019 Jan 24.

Department of Nephrology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Ischemia/reperfusion is a major cause of acute kidney injury and can induce apoptosis in renal epithelial tubule (HK-2) cells. Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a major contributor to apoptosis in acute kidney injury. We previously reported that augmenter of liver regeneration (ALR) functions as an anti-apoptotic factor in HO-treated HK-2 cells although the precise mechanism underlying this action remains unclear. Read More

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http://dx.doi.org/10.1007/s10495-019-01517-zDOI Listing
January 2019
3.685 Impact Factor

Correction to: MiRNA-126 expression inhibits IL-23R mediated TNF-α or IFN-γ production in fibroblast-like synoviocytes in a mice model of collagen-induced rheumatoid arthritis.

Apoptosis 2019 Jan 12. Epub 2019 Jan 12.

Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, No. 168 Changhai Road, Shanghai, 200433, China.

The authors would like to add an article note stating that "The authors Jie Gao and Ruina Kong have equally contributed to the article". Read More

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http://link.springer.com/10.1007/s10495-018-1503-6
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http://dx.doi.org/10.1007/s10495-018-1503-6DOI Listing
January 2019
4 Reads

Ultraspiracle-independent anti-apoptotic function of ecdysone receptors is required for the survival of larval peptidergic neurons via suppression of grim expression in Drosophila melanogaster.

Apoptosis 2019 Jan 14. Epub 2019 Jan 14.

Department of Biochemistry and Cellular and Molecular Biology and NeuroNet Research Center, University of Tennessee, Knoxville, TN, 37996, USA.

In Drosophila melanogaster a significant number of heterogenous larval neurons in the central nervous system undergo metamorphosis-associated programmed cell death, termed metamorphoptosis. Interestingly distinct groups of doomed larval neurons are eliminated at different metamorphic phases. Although ecdysone hormonal signaling via nuclear ecdysone receptors (EcRs) is known to orchestrate the neuronal metamorphoptosis, little is known about how this signaling controls such diverse neuronal responses. Read More

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http://dx.doi.org/10.1007/s10495-019-01514-2DOI Listing
January 2019

Cancer therapeutics based on BCL-2 functional conversion.

Apoptosis 2019 Feb;24(1-2):1-2

Cancer Research Laboratory, Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA.

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http://dx.doi.org/10.1007/s10495-018-1504-5DOI Listing
February 2019
1 Read

Clotam enhances anti-proliferative effect of vincristine in Ewing sarcoma cells.

Apoptosis 2019 Feb;24(1-2):21-32

Department of Pediatrics and Women's Health, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.

Current therapeutic strategies used in Ewing sarcoma (ES) especially for relapsed patients have resulted in modest improvements in survival over the past 20 years. Combination therapeutic approach presents as an alternative to overcoming drug resistance in metastatic ES. This study evaluated the effect of Clotam (tolfenamic acid or TA), a small molecule and inhibitor of Specificity protein1 (Sp1) and survivin for sensitizing ES cell lines to chemotherapeutic agent, vincristine (VCR). Read More

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http://link.springer.com/10.1007/s10495-018-1508-1
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http://dx.doi.org/10.1007/s10495-018-1508-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447082PMC
February 2019
8 Reads

MicroRNA-663 antagonizes apoptosis antagonizing transcription factor to induce apoptosis in epithelial cells.

Apoptosis 2019 Feb;24(1-2):108-118

Division of Periodontology, School of Dental Medicine, University of Geneva Faculty of Medicine, Geneva, Switzerland.

MicroRNAs are small functional RNAs that modulate various biological processes in cells by interfering with gene translation. We have previously demonstrated that certain miRNAs play a crucial role in the innate immune responses of human oral epithelial cells to Porphyromonas gingivalis. While addressing the mechanisms of P. Read More

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http://dx.doi.org/10.1007/s10495-018-01513-9DOI Listing
February 2019

Oxidative stress generated by irradiation of a zinc(II) phthalocyanine induces a dual apoptotic and necrotic response in melanoma cells.

Apoptosis 2019 Feb;24(1-2):119-134

Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Universidad de Buenos Aires, CONICET-UBA, Junín 956, C1113AAD, Buenos Aires, Argentina.

Melanoma is an aggressive form of skin carcinoma, highly resistant to traditional therapies. Photodynamic therapy (PDT) is a non-invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. In this work we evaluated the effect of a cationic zinc(II) phthalocyanine (Pc13) as photosensitizer on a panel of melanoma cells. Read More

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http://dx.doi.org/10.1007/s10495-018-01512-wDOI Listing
February 2019
1 Read

Cell death in the human infant central nervous system and in sudden infant death syndrome (SIDS).

Apoptosis 2019 Feb;24(1-2):46-61

Department of Medicine, The Bosch Institute, Medical Foundations Building, The University of Sydney, Sydney, NSW, 2006, Australia.

The brainstem has been a focus of sudden infant death syndrome (SIDS) research with amassing evidence of increased neuronal apoptosis. The present study extends the scope of brain regions examined and determines associations with known SIDS risk factors. Immunohistochemical expression of cell death markers, active caspase-3 and TUNEL, was studied in 37 defined brain regions in infants (aged 1-12 months) who died suddenly and unexpectedly (SUDI). Read More

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http://dx.doi.org/10.1007/s10495-018-1509-0DOI Listing
February 2019

Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.

Apoptosis 2019 Feb;24(1-2):145-156

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

Arginase has therapeutic potential as a cytotoxic agent in some cancers, but this is unclear for precursor B acute lymphoblastic leukaemia (pre-B ALL), the commonest form of childhood leukaemia. We compared arginase cytotoxicity with asparaginase, currently used in pre-B ALL treatment, and characterised the forms of cell death induced in a pre-B ALL cell line 697. Arginase and asparaginase both efficiently killed 697 cells and mature B lymphoma cell line Ramos, but neither enzyme killed normal lymphocytes. Read More

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http://dx.doi.org/10.1007/s10495-018-1506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373273PMC
February 2019
1 Read

Cornification of nail keratinocytes requires autophagy for bulk degradation of intracellular proteins while sparing components of the cytoskeleton.

Apoptosis 2019 Feb;24(1-2):62-73

Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Lazarettgasse 14, 1090, Vienna, Austria.

Epidermal keratinocytes undergo cornification to form the cellular building blocks of hard skin appendages such as nails and the protective layer on the surface of the skin. Cornification requires the cross-linking of structural proteins and the removal of other cellular components to form mechanically rigid and inert corneocytes. Autophagy has been proposed to contribute to this intracellular remodelling process, but its molecular targets in keratinocytes, if any, have remained elusive. Read More

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http://dx.doi.org/10.1007/s10495-018-1505-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373260PMC
February 2019
3 Reads

A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-κB mediated apoptosis-to-pyroptosis switch.

Apoptosis 2019 Feb;24(1-2):74-82

Chemical Biology Research Center, College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.

Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Read More

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http://link.springer.com/10.1007/s10495-018-1499-y
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http://dx.doi.org/10.1007/s10495-018-1499-yDOI Listing
February 2019
8 Reads
3.685 Impact Factor

Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.

Apoptosis 2019 Feb;24(1-2):168-183

Chongqing Productivity Promotion Center for the Modernization of Chinese Traditional Medicine, School of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, China.

The diversity of the bacterial community in the gut is closely related to human health. Gut microbes accomplish multiple physiological and biochemical functions. Sitosterols are a series of phytochemicals that have multiple pharmacological activities and are used as cholesterol-lowering drugs in clinical practice. Read More

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http://dx.doi.org/10.1007/s10495-018-1500-9DOI Listing
February 2019
1 Read
3.685 Impact Factor

NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo.

Apoptosis 2019 Feb;24(1-2):83-94

West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

KRAS mutations are one of the most prevalent genetic alterations in colorectal cancer (CRC). Although directly targeting KRAS still is a challenge in anti-cancer therapies, alternatively inhibiting KRAS related signaling pathways has been approached effectively. Here we firstly reported that MAP kinase, transforming growth factor-β-activated kinase 1 (TAK1), commonly expressed in CRC cell lines and significantly associated with KRAS mutation status. Read More

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http://dx.doi.org/10.1007/s10495-018-1498-zDOI Listing
February 2019
4 Reads

A real-time, bioluminescent annexin V assay for the assessment of apoptosis.

Apoptosis 2019 Feb;24(1-2):184-197

Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA.

Apoptosis is an important and necessary cell death program which promotes homeostasis and organismal survival. When dysregulated, however, it can lead to a myriad of pathologies from neurodegenerative diseases to cancer. Apoptosis is therefore the subject of intense study aimed at dissecting its pathways and molecular mechanisms. Read More

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http://link.springer.com/10.1007/s10495-018-1502-7
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http://dx.doi.org/10.1007/s10495-018-1502-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373262PMC
February 2019
1 Read

Molecular mechanisms of apoptosis and autophagy elicited by combined treatment with oridonin and cetuximab in laryngeal squamous cell carcinoma.

Apoptosis 2019 Feb;24(1-2):33-45

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Tianjin, 300193, People's Republic of China.

Combined oridonin (ORI), a natural and safe kaurene diterpenoid isolated from Rabdosia rubescens, and cetuximab (Cet), an anti-EGFR monoclonal antibody, have been reported to exert synergistic anti-tumor effects against laryngeal squamous cell carcinoma (LSCC) both in vitro and in vivo by our group. In the present study, we further found that ORI/Cet treatment not only resulted in apoptosis but also induced autophagy. AMPK/mTOR signaling pathway was found to be involved in the activation of autophagy in ORI/Cet-treated LSCC cells, which is independent of p53 status. Read More

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http://link.springer.com/10.1007/s10495-018-1497-0
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http://dx.doi.org/10.1007/s10495-018-1497-0DOI Listing
February 2019
11 Reads

PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.

Apoptosis 2019 Feb;24(1-2):135-144

Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Beijing, 100044, China.

We have previously identified that PPPDE1 is a deubiquitinase (DUB) belonging to a cysteine isopeptidase family. Here we sought to explore the biological significance of PPPDE1 in hepatocellular carcinoma and its underlying molecular mechanism. In the present study, we found that amplification and overexpression of PPPDE1 were associated with poor prognosis in hepatocellular carcinoma (HCC). Read More

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http://link.springer.com/10.1007/s10495-018-1491-6
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http://dx.doi.org/10.1007/s10495-018-1491-6DOI Listing
February 2019
11 Reads

Correction to: Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers.

Apoptosis 2019 Feb;24(1-2):204

Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, China.

The below funding information was not submitted and hence not included in the original publication. The funding information is given below. Read More

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http://link.springer.com/10.1007/s10495-018-1494-3
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http://dx.doi.org/10.1007/s10495-018-1494-3DOI Listing
February 2019
13 Reads
3.685 Impact Factor

Correction to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells.

Apoptosis 2019 Feb;24(1-2):200-203

Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 130-701, Republic of Korea.

The original version of this article contained mistakes in figures. The western blot data for pro-caspase-3 and cleaved caspase-3 (Fig. 1d), β-actin (Fig. Read More

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http://link.springer.com/10.1007/s10495-018-1493-4
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http://dx.doi.org/10.1007/s10495-018-1493-4DOI Listing
February 2019
20 Reads

Correction to: Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cγ1- and Ca-dependent pathway in mouse Neuro-2a neuroblastoma cells.

Apoptosis 2019 Feb;24(1-2):198-199

Department of Biochemistry and Molecular Biology, School of Medicine, Medical Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, Kyung Hee University, Seoul, 130-701, Republic of Korea.

The original version of this article contained a mistake in the figure. The Ca2 + confocal image for the 2-APB/Apicidin-120 min in Fig. 5d is incorrect. Read More

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http://dx.doi.org/10.1007/s10495-018-1492-5DOI Listing
February 2019
1 Read

Sigma-1 receptor protects against endoplasmic reticulum stress-mediated apoptosis in mice with cerebral ischemia/reperfusion injury.

Apoptosis 2019 Feb;24(1-2):157-167

Department of Pharmacology, Life Science and Biopharmaceutics School, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, Liaoning, People's Republic of China.

Reports have showed that Sigma-1 receptor (Sig-1R) activation can protect neurons against cerebral ischemia/reperfusion (I/R) injury in mice and alleviate endoplasmic reticulum (ER) stress in cultured cells, but little known is about the protective role of Sig-1R on ER stress induced by cerebral I/R. The purpose of this study was to determine whether Sig-1R exerts a protective effect against ER stress-mediated apoptosis in cerebral I/R using a 15-min bilateral common carotid artery occlusion (BCCAO) mouse model. At 72 h after reperfusion in BCCAO mice, we found that Sig-1R knockout (Sig-1R KO) significantly increased terminal dUTP nick-end labeling (TUNEL)-positive cells and nuclear structural damage in cortical neurons. Read More

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http://link.springer.com/10.1007/s10495-018-1495-2
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http://dx.doi.org/10.1007/s10495-018-1495-2DOI Listing
February 2019
1 Read

Klotho modulates ER-mediated signaling crosstalk between prosurvival autophagy and apoptotic cell death during LPS challenge.

Apoptosis 2019 Feb;24(1-2):95-107

Department of Animal Physiology and Reproduction, Faculty of Biotechnology, University of Rzeszow, Werynia 502, 36-100, Kolbuszowa, Poland.

Bacterial endotoxins have been shown to induce prosurvival autophagy or apoptosis in fibroblasts and thus impair the wound healing process. Endoplasmic reticulum has been proposed as a molecular switch between these processes and klotho protein possessing pleiotropic characteristics seems to be involved in both processes, however the exact molecular mechanism is unknown. In this study, we have evaluated the effect of klotho silencing on human fibroblasts exposed to a non-toxic dose of lipopolysaccharide in terms of in vitro wound healing ability. Read More

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http://link.springer.com/10.1007/s10495-018-1496-1
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http://dx.doi.org/10.1007/s10495-018-1496-1DOI Listing
February 2019
7 Reads

Correction to: Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress.

Apoptosis 2018 Dec;23(11-12):707-709

Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, Biomedical Science Institute, School of Medicine, Kyung Hee University, #1 Hoegi-dong, Dongdaemoon-gu, Seoul, 130-701, South Korea.

The original version of this article contained a mistake. The bands for HA Tag and t-ERK in Figs. 2d, 2h, 3d are incorrect. Read More

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http://link.springer.com/10.1007/s10495-018-1486-3
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http://dx.doi.org/10.1007/s10495-018-1486-3DOI Listing
December 2018
17 Reads