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Dermatol Online J 2021 01 15;27(1). Epub 2021 Jan 15.

Epiphany Dermatology, Dallas, TX,

Apocrine hidrocystoma is a benign, cystic proliferation of the apocrine sweat gland that may present commonly on sun-exposed areas of the head and neck. However, given its location and features, apocrine hidrocystomas may often be confused with malignant tumors such as basal cell carcinomas or primary cutaneous mucinous carcinomas. Herein, we present an unusual case of an apocrine hidrocystoma presenting in the postauricular region and highlight the importance of histopathological examination of cystic tumors on the periauricular area. Read More

J Craniofac Surg 2020 Nov 23. Epub 2020 Nov 23.

Ocular Tissue Engineering Research Center.

Intraconal orbital hidrocystoma is a very rare entity. Herein, a 6-month old boy with an intraconal apocrine hidrocystoma will be reported. The patient presented with a left-sided mild proptosis and significant anisometropic hypermetropia. Read More

Dermatol Online J 2020 Aug 15;26(8). Epub 2020 Aug 15.

Department of Dermatology, Emory School of Medicine, Atlanta, GA.

Hidrocystomas are benign cysts of sweat duct epithelium that can present as single or multiple lesions, with or without pigmentation. The size is typically 1-3mm in diameter. Although hidrocystomas commonly occur in most parts of the head and neck region, occurrence on the scalp is rare. Read More

Laser Ther 2020 Jul;29(1):73-75

Department of Dermatology, John Hunter Hospital, New Lambton, Australia.

Apocrine hidrocystomas are benign, cystic tumours arising from the apocrine sweat gland. They usually present as a solitary papule or nodule in the periorbital area and it is uncommon for multiple lesions to appear. We present a case of multiple apocrine hidrocystomas on the nasal dorsum which became apparent after ablative laser treatment. Read More

Chin Med J (Engl) 2020 Sep;133(17):2107-2108

Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

JBJS Case Connect 2020 Jul-Sep;10(3):e1900608

1Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, New York.

Case: A 26-year-old woman developed a painful enlarging mass in her left leg over the course of 4 years. Marginal resection and local adjuvant therapy was undertaken, and pathology confirmed the mass to be an apocrine hidrocystoma.

Conclusion: Giant apocrine hidrocystomas with osseous involvement outside of the head and neck are extremely rare. Read More

Iran J Public Health 2020 Feb;49(2):403-405

Department of Pediatric Surgery, Hedi-Chaker Hospital, Sfax, Tunisia.

Ann Dermatol Venereol 2020 May 9;147(5):361-365. Epub 2020 Mar 9.

Service de dermatologie, grand hôpital de Charleroi, rue de Villers 1, 6280 Loverval, Belgique.

Background: Apocrine hidrocystomas are benign cystic tumors that develop from apocrine gland proliferation. In most cases, they are translucent solitary lesions of the face, generally found in the periorbital region, on the scalp or on the neck. More rarely, apocrine hidrocystomas may be multiple and appear on the ears, trunk, shoulders and genital area. Read More

Indian J Otolaryngol Head Neck Surg 2019 Oct 19;71(Suppl 1):59-61. Epub 2016 Jul 19.

1Department of ENT and Head and Neck Surgery, KLE University's Jawaharlal Nehru Medical College, Belagavi, Karnataka 590010 India.

Hidrocystoma is a cystic tumor originating from a dilated sweat gland. The tumor is typically small and located predominantly on the face, particularly in the eyelid margins. They are two classical types of hidrocystomas i. Read More

Dermatol Online J 2019 Oct 15;25(10). Epub 2019 Oct 15.

Department of Dermatology, Consorcio Hospital General Universitario de Valencia.

Apocrine hidrocystoma is a rare, benign, cystic tumor of the apocrine sweat glands. They are most commonly located around the eyes and may also be found on the scalp and neck. However, despite the fact that the nipple and areola contain numerous apocrine sweet glands, apocrine hydrocystomas have not been described previously in this area to the best of our knowledge. Read More

BMJ Case Rep 2019 Aug 30;12(8). Epub 2019 Aug 30.

LV Prasad Eye Institute, Hyderabad, Telangana, India.

Pan Afr Med J 2019 30;33:70. Epub 2019 May 30.

Hôpital Civil Tétouan Maroc, Centre Hospitalier Régional Tétouan, Maroc.

Palpebral hidrocystomas are benign tumors also known as cystic apocrine adenoma, cyst of sweat gland, apocrine retention cyst or cyst of Moll. They originate from eccrine or apocrine sweat glands and often occur on the face and the eyelids. Other atypical locations such as the chest, the shoulders and the foreskin have been reported. Read More

J Med Case Rep 2019 Aug 1;13(1):237. Epub 2019 Aug 1.

Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, 710-8602, Japan.

Background: Serum carcinoembryonic antigen levels are often elevated in patients with malignant diseases. However, the etiology of elevated serum carcinoembryonic antigen levels may be extremely difficult to determine considering that this finding may occasionally occur in patients with benign diseases. Apocrine hidrocystomas, which are typically small and found on the face, are benign cystic lesions of apocrine sweat glands. Read More

Ann Dermatol 2019 Aug 1;31(4):442-445. Epub 2019 Jul 1.

Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, South Korea.

Apocrine hidrocystoma, also called apocrine cystadenoma, is a benign cystic tumor-like lesion that arises from the proliferation of apocrine glands. Clinically, it usually occurs singly as a unilocular or multilocular, dome-shaped translucent cyst. Histologically, it appears as unilocular or multilocular cysts composed of an inner layer of single or double layer of secretory columnar epithelium with decapitation secretion lying above an outer myoepithelial cell layer. Read More

Dermatol Online J 2019 Jun 15;25(6). Epub 2019 Jun 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Weill Cornell Medicine, New York, NY.

Apocrine hidrocystoma is a benign, cystic lesion often presenting in the periorbital region. Apocrine adenocarcinoma is the rare, malignant counterpart occurring mainly in the axilla and anogenital region. There is a paucity of literature on both entities and co-occurrence has been reported in only 5 cases. Read More

J Low Genit Tract Dis 2019 Jul;23(3):235-240

Department of Pathology, Immunology, University Hospital and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ.

Objectives: The aim of the study was to review uncommon foreskin dermatopathology conditions clinically and pathologically.

Methods: A database search of PubMed and Google Scholar were extracted between March 1, 2009, and March 1, 2019, using the search terms "foreskin," "prepuce," "penis," "pathology," "dermatology," and "rare." The search was limited to "humans" and "dermatopathology. Read More

An Bras Dermatol 2019 Mar-Apr;94(2):247-248. Epub 2019 May 9.

Discipline of Dermatology, Department of Medicine, Universidade de Taubaté, Taubaté (SP), Brazil.

Ophthalmic Plast Reconstr Surg 2019 May/Jun;35(3):e72-e74

Departments of Ophthalmology.

A cystic lesion of the eyelid margin in a 37-year-old man was diagnosed clinically as an apocrine hidrocystoma, a common lesion in that location. Histopathologic examination confirmed the presence of a hidrocystoma but also disclosed an extensive proliferation of bland epithelial cells arising from the inner layer of the cyst. The authors further characterized this unique occurrence on the spectrum of Moll gland eyelid tumors by immunohistochemical analysis. Read More

Dermatol Online J 2019 Feb 15;25(2). Epub 2019 Feb 15.

Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad.

Eccrine hidrocystoma is a benign cystic tumor. Such benign cystic lesions may be a cosmetic concern, or when large, can cause eyelid malpositions. We report a patient with a peri-punctal hidrocystoma of the eyelid. Read More

JAMA Ophthalmol 2019 Feb 14;137(2):e183975. Epub 2019 Feb 14.

Department of Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Am J Otolaryngol 2019 Mar - Apr;40(2):312-313. Epub 2019 Jan 28.

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA; Department of Biomedical Engineering, University of California, Irvine, USA. Electronic address:

Biomed Rep 2019 Feb 7;10(2):92-96. Epub 2018 Dec 7.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.

The aim of the present study was to investigate the clinicopathological features of cystic lesions in the eyelid. Clinicopathological profiles were retrospectively searched based on medical records of 35 patients with cystic lesions of the eyelids, which were surgically resected from January 2003 to June 2016. The cohort consisted of 16 men and 19 women. Read More

Indian Dermatol Online J 2018 Nov-Dec;9(6):448-451

Department of Dermatology, Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Schopf-Schulz-Passarge syndrome (SSPS) is a rare type of ectodermal dysplasia that has autosomal recessive inheritance. It is characterized by palmoplantar keratoderma, hypodontia, hypotrichosis, nail dystrophy, and multiple periocular and eyelid apocrine hidrocystomas. A 36-year-old male presented with multiple eyelid and periocular apocrine hidrocystomas, ichthyosis, palmoplantar keratoderma, hypodontia, nail dystrophy, and thin scalp hair. Read More

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

Case Rep Pathol 2018 26;2018:4263104. Epub 2018 Jul 26.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Thailand.

We report a case of vulvar clear cell adenocarcinoma in a woman presenting with a lump and pain in the right side of the labia majora. Three years prior to this visit, she underwent a total abdominal hysterectomy with bilateral salpingooophorectomy and excision of a labial mass. Pathological examination revealed adenomyosis and multiple leiomyomas in the uterus, endometriotic cysts in both ovaries, and foci of atypical endometriosis in the labial mass. Read More

Dermatopathology (Basel) 2018 Apr-Jun;5(2):79-85. Epub 2018 Jun 7.

Department of Pharmacology and Toxicology, University of Geneva, Geneva, Switzerland.

Cutaneous cysts have been classified by dermatopathologists in many different ways. Here, we propose a novel classification of cutaneous adnexal cysts according to their origin in the folliculosebaceous unit and the sweat glands. By examining the lining of the cystic structure, its origin can be easily identified. Read More

Pediatr Dermatol 2018 Jul 6;35(4):e231-e232. Epub 2018 Apr 6.

Department of Dermatology, School of Medicine, Tokai University, Kanagawa, Japan.

Apocrine hidrocystomas are mostly found on the cheeks and eyelids but also on the scalp and neck. The age distribution is from 30 to 70 years old. We report a case of an apocrine hidrocystoma on the genitalia of a 9-year-old girl. Read More

Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.

Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

Hidrocystomas are benign cysts that typically present as translucent, bluish dermal nodules on the face and are rarely > 1 cm in size. They are classically categorized as eccrine or apocrine based on histologic features. We present a rare case of a giant apocrine hidrocystoma of the trunk, demonstrating that, although a rare variant, apocrine hidrocystomas can present both off the head and neck, and can be significantly larger in size than previously reported. Read More

Ophthalmic Plast Reconstr Surg 2018 May/Jun;34(3):e83-e85

Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA and Associate Eye Physicians and Surgeons, Quincy, Massachusetts, U.S.A.

A 53-year-old man presented with smooth-domed, variegated cysts (polycystic disease) of all 4 eyelids, worse on the left side. Some of the cysts were clear, while others were creamy-white colored. In addition, multiple, very fine vesicopapules were noted along the eyelid margins. Read More

J Dtsch Dermatol Ges 2018 Jan;16(1):66-69

Department of Dermatology and Allergology, University Hospital of RWTH Aachen, Aachen, Germany.