Search Our Scientific Publications & Authors

SAGE Open Med Case Rep 2022 11;10:2050313X221097770. Epub 2022 May 11.

Department of Ophthalmology, General Hospital G. Papanikolaou, Thessaloniki, Greece.

Hidrocystomas are benign lesions with frequent localization on the eyelids and common appearance as isolated translucent cystic lesions. The multiple and bilateral localization has been associated with systemic diseases or epidermodysplasia. The histological and ultrastructural study contributes to the distinction in eccrine or apocrine. Read More

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA.

Apocrine hidrocystoma (AH) is a benign cystic proliferation of apocrine sweat glands that classically presents as a slow-growing nodule on the face, especially in the periorbital region. Histopathological evaluation is required to definitively diagnose an apocrine hidrocystoma. Previous studies have described apocrine hidrocystomas in unusual locations. Read More

Top Companion Anim Med 2022 Jan-Feb;46:100594. Epub 2021 Oct 26.

Department of Animal Medicine, Faculty of Veterinary Sciences, Federal University of Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.

Apocrine hidrocystoma (AH) is a benign cystic lesion infrequently reported in the eyelids of cats. There are several reports of application of trichloroacetic acid (TCA) for treatment of eyelid apocrine hidrocystomas with high success rates in humans. This is the first report of intralesional injection of TCA for the treatment of eyelid AH in a feline. Read More

J Cutan Pathol 2022 Feb 8;49(2):172-175. Epub 2021 Oct 8.

Department of Pathology and Laboratory Medicine, Saskatchewan Health Authority, Saskatoon, Canada.

A 20-year-old female presented to a gynecologist with an irregular, darkly pigmented, vulvar lesion. Histopathologic sections of a biopsy specimen showed cystically dilated glands with apical snouts, pigmented secretion, and numerous dendritic melanocytes. The lesion was diagnosed as a pigmented apocrine hamartoma of the vulva. Read More

Dermatopathology (Basel) 2021 Sep 1;8(3):442-445. Epub 2021 Sep 1.

Department of Pathology, University Hospital of Geneva, 1205 Geneva, Switzerland.

We described a new case of a hybrid epidermoid and apocrine cyst, known to be a rare histopathological entity. The cyst was located in the axillary region and completely excised, without complication. The diagnosis was made at the histological analysis, where we found a cystic lesion in the dermis, lined with both epidermoid and apocrine epithelium. Read More

Pathol Int 2021 Nov 2;71(11):783-788. Epub 2021 Sep 2.

Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.

Some skin adnexal tumors display both epithelial and myoepithelial cell populations and can be broadly categorized as biphasic tumors. These include apocrine hidrocystoma, mixed tumor, adenomyoepithelioma (AME), and adenoid cystic carcinoma (ACC). Myoepithelioma is the myoepithelial cell-predominant type in this category. Read More

Ophthalmic Plast Reconstr Surg 2021 Nov-Dec 01;37(6):e208-e209

Department of Ophthalmology.

Apocrine hidrocystomas are benign cystic tumors derived from apocrine sweat glands; they are most commonly located in the skin of the head and neck regions. Ophthalmic occurrences characteristically appear at the lash line and canthi of the eyelid, although rare instances have been described in the conjunctiva, caruncle, and orbit. The authors describe an exceptional instance of a mobile epibulbar subconjunctival apocrine hidrocystoma in a 57-year-old woman without a history of previous ocular injury or surgery. Read More

Ear Nose Throat J 2021 Jul 5:1455613211031028. Epub 2021 Jul 5.

Department of Otorhinolaryngology, Habib Bourguiba hospital, Sfax, Tunisia.

Apocrine hidrocystoma is a cystic tumor originating from apocrine sweat glands. It is predominantly located in the eyelid margins. Here, we report a case of apocrine hidrocystoma of the parotid gland in a 19-year-old man who was referred to our outpatient clinic with a 5-year history of a gradual swelling in the left parotid region. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2021 06;30(2):53-56

Department of Plastic Surgery, University Hospital of Heraklion, Crete, Greece.

Introduction: Eccrine and apocrine hidrocystomas are uncommon, benign, cystic proliferations of the sweat glands usually located on the head and neck area.

Objectives: To describe the key clinical and histopathological characteristics of a large series of hidrocystomas in Greece to improve diagnostic accuracy, and to perform a historical review of the medical term hidrocystoma.

Methods: A case series of 22 hidrocystomas from 20 consecutive patients treated with surgery at University Hospital of Heraklion in Crete, Greece, from January 1, 1998 to January 1, 2020 was performed along with a comprehensive historical literature review of the term hidrocystoma and its corresponding term hydatis from ancient Greek literature to the present. Read More

Otol Neurotol 2021 09;42(8):e1181-e1183

Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Am J Dermatopathol 2022 Feb;44(2):92-97

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Abstract: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade adnexal malignancy with a predilection for the eyelids of elderly White women, which is associated with invasive mucinous carcinoma with endocrine features in one-third of cases. EMPSGC is characterized by the presence of neuroendocrine differentiation and mucin production. However, EMPSGC displays a variety of architectural patterns including solid, cribriform, papillary, and cystic growth. Read More

Dermatol Online J 2021 01 15;27(1). Epub 2021 Jan 15.

Epiphany Dermatology, Dallas, TX,

Apocrine hidrocystoma is a benign, cystic proliferation of the apocrine sweat gland that may present commonly on sun-exposed areas of the head and neck. However, given its location and features, apocrine hidrocystomas may often be confused with malignant tumors such as basal cell carcinomas or primary cutaneous mucinous carcinomas. Herein, we present an unusual case of an apocrine hidrocystoma presenting in the postauricular region and highlight the importance of histopathological examination of cystic tumors on the periauricular area. Read More

J Dtsch Dermatol Ges 2021 04 14;19(4):605-607. Epub 2021 Jan 14.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Acta Derm Venereol 2020 Dec 14;100(19):adv00350. Epub 2020 Dec 14.

Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, POB 12000, Jerusalem 9112001, Israel.

J Craniofac Surg 2021 Jul-Aug 01;32(5):e444-e446

Ocular Tissue Engineering Research Center.

Abstract: Intraconal orbital hidrocystoma is a very rare entity. Herein, a 6-month old boy with an intraconal apocrine hidrocystoma will be reported. The patient presented with a left-sided mild proptosis and significant anisometropic hypermetropia. Read More

Dermatol Online J 2020 Aug 15;26(8). Epub 2020 Aug 15.

Department of Dermatology, Emory School of Medicine, Atlanta, GA.

Hidrocystomas are benign cysts of sweat duct epithelium that can present as single or multiple lesions, with or without pigmentation. The size is typically 1-3mm in diameter. Although hidrocystomas commonly occur in most parts of the head and neck region, occurrence on the scalp is rare. Read More

Laser Ther 2020 Jul;29(1):73-75

Department of Dermatology, John Hunter Hospital, New Lambton, Australia.

Apocrine hidrocystomas are benign, cystic tumours arising from the apocrine sweat gland. They usually present as a solitary papule or nodule in the periorbital area and it is uncommon for multiple lesions to appear. We present a case of multiple apocrine hidrocystomas on the nasal dorsum which became apparent after ablative laser treatment. Read More

Chin Med J (Engl) 2020 Sep;133(17):2107-2108

Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

JBJS Case Connect 2020 Jul-Sep;10(3):e1900608

1Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, New York.

Case: A 26-year-old woman developed a painful enlarging mass in her left leg over the course of 4 years. Marginal resection and local adjuvant therapy was undertaken, and pathology confirmed the mass to be an apocrine hidrocystoma.

Conclusion: Giant apocrine hidrocystomas with osseous involvement outside of the head and neck are extremely rare. Read More

Am J Clin Dermatol 2020 Dec;21(6):855-880

Washington Institute of Dermatologic Laser Surgery, 1430 K St NW, Suite 200, Washington, DC, 20005, USA.

Botulinum toxin type A (BoNTA) is a powerful neurotoxin that inhibits acetylcholine release from presynaptic vesicles. The potency and safety profile of BoNTA grant the toxin vast therapeutic potential. It has been used off-label for a variety of dermatologic conditions. Read More

Iran J Public Health 2020 Feb;49(2):403-405

Department of Pediatric Surgery, Hedi-Chaker Hospital, Sfax, Tunisia.

Ann Dermatol Venereol 2020 May 9;147(5):361-365. Epub 2020 Mar 9.

Service de dermatologie, grand hôpital de Charleroi, rue de Villers 1, 6280 Loverval, Belgique.

Background: Apocrine hidrocystomas are benign cystic tumors that develop from apocrine gland proliferation. In most cases, they are translucent solitary lesions of the face, generally found in the periorbital region, on the scalp or on the neck. More rarely, apocrine hidrocystomas may be multiple and appear on the ears, trunk, shoulders and genital area. Read More

J Dermatolog Treat 2021 Dec 23;32(8):997-998. Epub 2020 Jan 23.

Department of Dermatology, National Skin Centre, Singapore.

Eccrine hidrocystomas (EH) are benign cystic tumors of the eccrine glands with no established treatment yet. Eccrine glands are activated by acetylcholine released from innervating sympathetic nerve fibers. Use of oral anti-cholinergic agents is rare due to the possibility of systemic side effects while topical atropine and scopolamine have been found to be ineffective. Read More

Indian J Otolaryngol Head Neck Surg 2019 Oct 19;71(Suppl 1):59-61. Epub 2016 Jul 19.

1Department of ENT and Head and Neck Surgery, KLE University's Jawaharlal Nehru Medical College, Belagavi, Karnataka 590010 India.

Hidrocystoma is a cystic tumor originating from a dilated sweat gland. The tumor is typically small and located predominantly on the face, particularly in the eyelid margins. They are two classical types of hidrocystomas i. Read More

Dermatol Online J 2019 Oct 15;25(10). Epub 2019 Oct 15.

Department of Dermatology, Consorcio Hospital General Universitario de Valencia.

Apocrine hidrocystoma is a rare, benign, cystic tumor of the apocrine sweat glands. They are most commonly located around the eyes and may also be found on the scalp and neck. However, despite the fact that the nipple and areola contain numerous apocrine sweet glands, apocrine hydrocystomas have not been described previously in this area to the best of our knowledge. Read More

BMJ Case Rep 2019 Aug 30;12(8). Epub 2019 Aug 30.

LV Prasad Eye Institute, Hyderabad, Telangana, India.

Pan Afr Med J 2019 30;33:70. Epub 2019 May 30.

Hôpital Civil Tétouan Maroc, Centre Hospitalier Régional Tétouan, Maroc.

Palpebral hidrocystomas are benign tumors also known as cystic apocrine adenoma, cyst of sweat gland, apocrine retention cyst or cyst of Moll. They originate from eccrine or apocrine sweat glands and often occur on the face and the eyelids. Other atypical locations such as the chest, the shoulders and the foreskin have been reported. Read More

J Med Case Rep 2019 Aug 1;13(1):237. Epub 2019 Aug 1.

Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, 710-8602, Japan.

Background: Serum carcinoembryonic antigen levels are often elevated in patients with malignant diseases. However, the etiology of elevated serum carcinoembryonic antigen levels may be extremely difficult to determine considering that this finding may occasionally occur in patients with benign diseases. Apocrine hidrocystomas, which are typically small and found on the face, are benign cystic lesions of apocrine sweat glands. Read More

Ann Dermatol 2019 Aug 1;31(4):442-445. Epub 2019 Jul 1.

Department of Dermatology, Gyeongsang National University School of Medicine, Jinju, South Korea.

Apocrine hidrocystoma, also called apocrine cystadenoma, is a benign cystic tumor-like lesion that arises from the proliferation of apocrine glands. Clinically, it usually occurs singly as a unilocular or multilocular, dome-shaped translucent cyst. Histologically, it appears as unilocular or multilocular cysts composed of an inner layer of single or double layer of secretory columnar epithelium with decapitation secretion lying above an outer myoepithelial cell layer. Read More

Dermatol Online J 2019 Jun 15;25(6). Epub 2019 Jun 15.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Weill Cornell Medicine, New York, NY.

Apocrine hidrocystoma is a benign, cystic lesion often presenting in the periorbital region. Apocrine adenocarcinoma is the rare, malignant counterpart occurring mainly in the axilla and anogenital region. There is a paucity of literature on both entities and co-occurrence has been reported in only 5 cases. Read More