118,336 results match your criteria Apocrine Hidrocystoma


Genomic characterization, phylogenetic position and in situ localization of a novel putative mononegavirus in Lepeophtheirus salmonis.

Arch Virol 2018 Dec 7. Epub 2018 Dec 7.

Sea Lice Research Centre, Department of Biological Sciences, University of Bergen, Thormøhlensgt. 55, Pb. 7803, 5020, Bergen, Norway.

The complete genome sequence of a novel mononegavirus, Lepeophtheirus salmonis negative-stranded RNA virus 1 (LsNSRV-1), obtained from a salmonid ectoparasite, Lepeophtheirus salmonis was determined. The viral genome contains five open reading frames encoding three unknown proteins (ORF I, II and III), a putative glycoprotein (G), and a large (L) protein. Phylogenetic analysis placed LsNSRV-1 in the recently established mononegaviral family Artoviridae. Read More

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December 2018

A Case of Sjögren's Syndrome Mimicking Inflammatory Myopathy.

Cureus 2018 Oct 1;10(10):e3393. Epub 2018 Oct 1.

Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.

Sjögren's syndrome (SS) is a chronic autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands and causing the decreased function of lacrimal and salivary glands. We describe a case of a 34-year-old male who presented with Sjögren's syndrome presenting as myopathy and sensorimotor neuropathy. His creatinine kinase levels were elevated with positive anti-Sjögren's syndrome-related antigen A autoantibodies and anti-Sjögren's syndrome Type B autoantibodies. Read More

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October 2018

Erector spinae block for postoperative analgesia following axillary hidradenitis suppurativa resection: a case report.

Local Reg Anesth 2018 15;11:87-90. Epub 2018 Nov 15.

Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA,

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the terminal hair follicle of the apocrine gland-bearing skin, presenting with inflamed nodules, abscesses, and sinus tracts. Autoimmune, genetic, and infectious factors have been implicated in its pathogenesis. HS can be managed medically using topical and systemic antibiotics and with tumor necrosis factor antibody therapy in severe cases. Read More

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November 2018

Apocrine papillary lesion: comparison of pathological findings from 22 years previously and the present.

Breast Cancer 2018 Dec 5. Epub 2018 Dec 5.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Apocrine papillary lesion (APL) is difficult to diagnose as benign or malignant. We experienced an APL remaining in the body for 22 years. We present a case of a 71-year-old woman who had undergone excisional biopsy 22 years previously at the first hospital that she visited. Read More

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December 2018

Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome.

Front Immunol 2018 16;9:2661. Epub 2018 Nov 16.

Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain.

Sjögren's Syndrome (SjS) is a common chronic autoimmune disease characterized by the B cell hyperactivation, lymphocyte infiltration, and tissue damage of exocrine glands. It can also present life-threatening extraglandular manifestations, such as pulmonary and hepatic involvement, renal inflammation and marginal zone (MZ) B cell lymphoma. Several biologic agents have been tested in SjS but none has shown significant efficacy. Read More

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November 2018
1 Read

Schopf-Schulz-Passarge Syndrome.

Indian Dermatol Online J 2018 Nov-Dec;9(6):448-451

Department of Dermatology, Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Schopf-Schulz-Passarge syndrome (SSPS) is a rare type of ectodermal dysplasia that has autosomal recessive inheritance. It is characterized by palmoplantar keratoderma, hypodontia, hypotrichosis, nail dystrophy, and multiple periocular and eyelid apocrine hidrocystomas. A 36-year-old male presented with multiple eyelid and periocular apocrine hidrocystomas, ichthyosis, palmoplantar keratoderma, hypodontia, nail dystrophy, and thin scalp hair. Read More

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December 2018

Expression of Three Adipokines (Adiponectin, Leptin and Resistin) in Normal Canine Skin: a Pilot Study.

J Comp Pathol 2018 Nov 28. Epub 2018 Nov 28.

Dermatology/Parasitology/Mycology Unit, School of Veterinary Medicine-ONIRIS, University of Nantes, CS 40706, Nantes, France; NP3 Unit, School of Veterinary Medicine-ONIRIS, University of Nantes, CS 40706, Nantes 44307, France. Electronic address:

Adipokines are biologically active cytokines that are mainly produced in adipose tissue. There is evidence, in man and mice, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. Moreover, modified serum levels of adipokines have been detected in people with acne vulgaris or psoriasis; it is suspected that adipokines could contribute to local and systemic inflammatory conditions. Read More

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November 2018
1 Read

Fine structure of the silk gland in the mite Ornithocheyletia sp. (Prostigmata, Cheyletidae).

J Morphol 2018 Dec 5. Epub 2018 Dec 5.

Zoological Institute, Russian Academy of Sciences, Saint-Petersburg, Russia.

Silk spinning is widely-spread in trombidiform mites, yet scarse information is available on the morphology of their silk glands. Thus this study describes the fine structure of the prosomal silk glands in a small parasitic mite, Ornithocheyletia sp. (Cheyletidae). Read More

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December 2018

Volumetric decrease of pancreas after abdominal irradiation, it is time to consider pancreas as an organ at risk for radiotherapy planning.

Radiat Oncol 2018 Dec 3;13(1):238. Epub 2018 Dec 3.

Department of Radiation Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.

Background: Volumetric shrinkage of normal tissues such as salivary glands, kidneys, hippocampus are observed after radiotherapy. We aimed to assess the alterations in pancreatic volume of patients who received abdominal radiotherapy and define pancreas as an organ at risk for radiation treatment planning.

Material-methods: Forty-nine patients operated for gastric adenocarcinoma who received adjuvant abdominal radiotherapy were in the study group, 27 patients with early stage disease who did not need adjuvant treatment after surgery comprised the control group. Read More

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December 2018
1 Read

Clinicopathological characteristics of breast sebaceous adenocarcinoma.

Pol J Pathol 2018 ;69(3):226-233

Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. Read More

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January 2018
2 Reads

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 Feb;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

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February 2019

Understanding the microbial basis of body odor in pre-pubescent children and teenagers.

Microbiome 2018 Nov 29;6(1):213. Epub 2018 Nov 29.

Computational and Systems Biology, Genome Institute of Singapore, Singapore, 138672, Singapore.

Background: Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it is believed to give rise to body odor in humans. While mechanisms of odor generation have been widely studied in adults, little is known for teenagers and pre-pubescent children who have distinct sweat composition from immature apocrine and sebaceous glands, but are arguably more susceptible to the social and psychological impact of malodor.

Results: We integrated information from whole microbiome analysis of multiple skin sites (underarm, neck, and head) and multiple time points (1 h and 8 h after bath), analyzing 180 samples in total to perform the largest metagenome-wide association study to date on malodor. Read More

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November 2018
3 Reads

Primary cutaneous apocrine carcinoma arising within a nevus sebaceus.

Cutis 2018 Oct;102(4):291-294

Nova Southeastern University College of Osteopathic Medicine/Largo Medical Center, Florida, USA.

Nevus sebaceus (NS)(organoid nevus) is a benign follicular neoplasm that commonly occurs on the scalp, face, or neck. With time, it may give rise to benign or malignant tumors such as trichoblastoma, syringocystadenoma papilliferum, and basal cell carcinoma (BCC). Rarely, other types of neoplasms may develop. Read More

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October 2018
1 Read

Overlooked adenocarcinoma of the scalp.

JAAPA 2018 Dec;31(12):27-28

Elena Elefteriou-Kokolis practices at the Hippocratic Medical Center in Tarpon Springs, Fla. Randy Danielsen is dean and a professor at the Arizona School of Health Sciences at A.T. Still University in Mesa, Ariz. Rodamanthos Nicholas Kokolis practices at the Hippocratic Medical Center. The authors have disclosed no potential conflicts of interest, financial or otherwise.

An apocrine adenocarcinoma of the scalp is a rare diagnosis in internal medicine. The article reviews the pathophysiology of the diagnosis and new, nonsurgical treatment options including radiation therapy and topical chemotherapy treatments. Read More

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December 2018

Pleomorphic and Florid Lobular Carcinoma in Situ Variants of the Breast: A Clinicopathologic Study of 85 Cases With and Without Invasive Carcinoma From a Single Academic Center.

Am J Surg Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, University of California San Francisco, San Francisco, CA.

The natural history and optimal treatment of pleomorphic (PLCIS) and florid (FLCIS) lobular carcinoma in situ variants remains uncertain. We reviewed the clinicopathologic features and management of LCIS variants at our institution over a 20-year period. Of 85 cases (61 PLCIS, 24 FLCIS), 77% were associated with invasive carcinoma (84% lobular, 13% ductal/lobular, 3% ductal) and only 17% (9 PLCIS, 5 FLCIS) were pure. Read More

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November 2018

Chi-miR-3031 regulates beta-casein via the PI3K/AKT-mTOR signaling pathway in goat mammary epithelial cells (GMECs).

BMC Vet Res 2018 Nov 27;14(1):369. Epub 2018 Nov 27.

College of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi, 712100, People's Republic of China.

Background: MicroRNAs can regulate gene expression at the posttranscriptional level through translational repression or target degradation. Our previous investigations examined the differential expression levels of chi-miR-3031 in caprine mammary gland tissues in colostrum and common milk stages.

Results: The present study detected the role of chi-miR-3031 in the lactation mechanisms of GMECs. Read More

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November 2018

Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome.

Ann Rheum Dis 2018 Nov 24. Epub 2018 Nov 24.

Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical & Dental Sciences, University of Birmingham, Research Laboratories, Queen Elizabeth Hospital, Birmingham, UK

Background: The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration and has been successfully targeted in B-cell malignancies. Primary Sjögren's syndrome (pSS) is a chronic immune-mediated inflammatory disease characterised by exocrine gland lymphocytic infiltration and B-cell hyperactivation which results in systemic manifestations, autoantibody production and loss of glandular function. Given the central role of B cells in pSS pathogenesis, we investigated PI3Kδ pathway activation in pSS and the functional consequences of blocking PI3Kδ in a murine model of focal sialoadenitis that mimics some features of pSS. Read More

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November 2018
1 Read

Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers.

Am J Otolaryngol 2019 Jan - Feb;40(1):110-114. Epub 2018 Sep 22.

Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.

Objectives: Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic factors that could impact survival. Read More

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September 2018
7 Reads

Primary Sjögren's syndrome.

Authors:
S J Bowman

Lupus 2018 Oct;27(1_suppl):32-35

Rheumatology Department, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder characterized by focal lymphocytic infiltration of the exocrine glands causing dry eyes and dry mouth. Similar glandular features can also occur as a late complication in patients with other rheumatic disorders, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and scleroderma ('secondary' Sjögren's syndrome). Anti-Ro and/or anti-La (ENA) antibodies are found in approximately 70% of pSS patients, generally with ANA positivity. Read More

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October 2018
2 Reads

Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5.

J Enzyme Inhib Med Chem 2019 Dec;34(1):179-188

a Department of Physiology , College of Medicine, Gachon University , Incheon , Republic of Korea.

Patients carrying the carbonic anhydrase12 E143K mutation showed the dry mouth phenotype. The mechanism underlying the modulation of aquaporin 5 and function in the salivary glands by carbonic anhydrase12 remains unknown. In this study, we identified the mislocalised aquaporin 5 in the salivary glands carrying the E143K. Read More

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December 2019
3 Reads

Large-Gland Proliferations of the Prostate.

Surg Pathol Clin 2018 Dec 17;11(4):687-712. Epub 2018 Oct 17.

Department of Pathology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address:

Large-gland proliferations of the prostate have gained considerable attention in the past decade. The differential diagnosis is quite broad but can be refined using histologic criteria and, sometimes, immunostains. Pathologists have come to realize that cribriform and intraductal as well as ductal carcinomas are particularly aggressive patterns, and should name them in diagnostic reporting when present. Read More

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December 2018

Sensor-Based Detection of the Severity of Hyperkeratosis in the Teats of Dairy Cows.

Sensors (Basel) 2018 Nov 14;18(11). Epub 2018 Nov 14.

Hochschule Neubrandenburg, Department of Agricultural Machinery, University of Applied Science, Brodaer Straße 2, 17033 Neubrandenburg, Germany.

The aim of this study was to evaluate whether the severity of hyperkeratosis (HK) in the teats of dairy cows can be assessed by a dielectric measurement. The study focused on surveying the occurrence of hyperkeratosis in a total of 241 teats of lactating dairy cows. A scoring system consisting of four categories was used to macroscopically assess the severity of HK. Read More

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November 2018
2 Reads

Apocrine lesions of the breast: part 2 of a two-part review. Invasive apocrine carcinoma, the molecular apocrine signature and utility of immunohistochemistry in the diagnosis of apocrine lesions of the breast.

J Clin Pathol 2018 Nov 13. Epub 2018 Nov 13.

Histopathology, Breast Check, Irish National Breast Screening Programme and St. Vincent's University Hospital, Dublin, Ireland.

Pure apocrine carcinoma of the breast is rare and has been defined by using a combination of morphologic (apocrine morphology in >90% of tumour cells) and immunohistochemical criteria (oestrogen receptor (ER) and progesterone receptor (PR) negative and androgen receptor (AR) positive). Recent advances in the molecular classification of breast tumours have uncovered a subset of breast tumours associated with high expression of androgen receptor mRNA including the so-called 'luminal androgen receptor (LAR) tumours' and 'molecular apocrine tumours' (MATs). Recognition of these tumour subsets has opened potential avenues for therapies exploiting the AR pathway in triple negative breast carcinoma (TNBC). Read More

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November 2018
2 Reads

Helicobacter pylori infection in Sjögren's syndrome:Co-incidence or causality?

Curr Rheumatol Rev 2018 Nov 12. Epub 2018 Nov 12.

Joint, bone and connective tissue research center, Golestan University of medical Sciences, Gorgan. Iran.

Background And Aim: Lymphoid cell infiltration and destruction of exocrine glands, specifically lacrimal and salivary glands are characteristics of Sjogren's syndrome (SS). An etiological role has been proposed for Helicobacter pylori (H.Pylori), interacting in the clinical course and complications of SS (including gastric cancer and lymphoma). Read More

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November 2018
5 Reads

Syringocystadenoma papilliferum of the cervix presenting as vulvar growth in an adolescent girl.

Clin Exp Dermatol 2019 Jan 11;44(1):58-61. Epub 2018 Nov 11.

Department of Dermatology, Seth G.S Medical College and KEM Hospital, Mumbai, India.

Syringocystadenoma papilliferum (SCP) is a rare, benign, adnexal tumour of apocrine or eccrine differentiation. It is commonly located on head and neck region. We report the case of an 18-year-old woman who presented with a vulvar lobulated growth that was found to arise from the posterior lip of cervix. Read More

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January 2019
1 Read

Shortening of Incision by "Pinch and Turn-Over Technique" in the Treatment of Axillary Osmidrosis.

Authors:
Eui-Tae Lee

Aesthetic Plast Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of Plastic and Reconstructive Surgery, Chungbuk National University College of Medicine, 1, Chungdae-Ro, Seowon-gu, Cheongju, Chungbuk, 28644, Korea.

Background: The pinch and turn-over technique was developed to minimize the incision in the manual subdermal excision of apocrine glands in axillary osmidrosis for the best cure and fewest complications.

Methods: Through a 2-cm-long incision, peripheral subdermal tissue was excised by the technique under direct vision using intravenous anesthesia and tumescent technique. Ninety-nine axillae in 50 patients including seven secondary cases were operated on from 2009 to 2018. Read More

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November 2018
5 Reads

Apocrine lesions of the breast: part 1 of a two-part review: benign, atypical and in situ apocrine proliferations of the breast.

J Clin Pathol 2018 Nov 8. Epub 2018 Nov 8.

Department of Histopathology, St Vincent's University Hospital, Dublin, Ireland.

Apocrine morphology is a common phenomenon encountered in everyday breast pathology practice, and is defined as cuboidal or columnar cells exhibiting abundant eosinophilic granular cytoplasm, prominent apical granules, a low nuclear-cytoplasmic ratio, and round nuclei with pale chromatin and prominent nucleoli. Apocrine morphology is recognised in benign, atypical and malignant lesions of the breast. The morphology of apocrine atypia and non-high-grade apocrine ductal carcinoma in situ (DCIS) is less well defined due to the relative rarity of these lesions. Read More

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November 2018
8 Reads

The effects of a forced-air warming system plus electric blanket for elderly patients undergoing transurethral resection of the prostate: A randomized controlled trial.

Medicine (Baltimore) 2018 Nov;97(45):e13119

Department of Operation Room, Liaocheng People's Hospital, Liaocheng, Shandong, China.

Background: Perioperative inadvertent hypothermia in elderly urology patients undergoing transurethral resection of the prostate (TURP) is a well-known serious complication, as it increases the risk of myocardial ischemia, blood loss, and surgical wound infection. We conducted this prospective randomized controlled trial to evaluate the combined effect of a forced-air warming system and electric blanket in elderly TURP patients.

Methods: Between January 2015 and October 2017, we recruited 443 elderly male patients undergoing elective TURP with subarachnoid blockade (SAB). Read More

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November 2018
8 Reads

Androgen excess in breast cancer development: implications for prevention and treatment.

Endocr Relat Cancer 2018 Nov 1. Epub 2018 Nov 1.

V Krogh, Nutritional Epidemiology Unit, Fondazione IRCSS Istituto Nazionale Tumori, Milan, 20133, Italy.

The aim of this review is to highlight the pivotal role of androgen excess in the development of breast cancer. Available evidence suggests that testosterone controls breast epithelial growth through a balanced interaction between its two active metabolites: cell proliferation is promoted by estradiol while it is inhibited by dihydrotestosterone. A chronic overproduction of testosterone (e. Read More

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November 2018
1 Read

MicroRNA-23b and microRNA-27b plus flutamide treatment enhances apoptosis rate and decreases CCNG1 expression in a castration-resistant prostate cancer cell line.

Tumour Biol 2018 Nov;40(11):1010428318803011

1 Laboratory of Medical Investigation (LIM55), Urology Department, University of Sao Paulo Medical School, Sao Paulo, Brazil.

The acquisition of a castration-resistant prostate cancer phenotype by prostate cancer cells is the alteration that has the worst prognosis for patients. The aim of this study was to evaluate the role of the microRNAs-23b/-27b as well as the possible CCNG1 target gene in tissue samples from patients with localized prostate cancer that progressed to castration-resistant prostate cancer and in a castration-resistant prostate cancer cell line (PC-3). The microRNAs and target gene expression levels of the surgical specimens were analyzed by quantitative real-time polymerase chain reaction. Read More

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November 2018
4 Reads

Integrated Epigenetic Mapping of Human and Mouse Salivary Gene Regulation.

J Dent Res 2018 Nov 4:22034518806518. Epub 2018 Nov 4.

1 Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Significant effort has been applied to identify the genome-wide gene expression profiles associated with salivary gland development and pathophysiology. However, relatively little is known about the regulators that control salivary gland gene expression. We integrated data from DNase1 digital genomic footprinting, RNA-seq, and gene expression microarrays to comprehensively characterize the cis- and trans-regulatory components controlling gene expression of the healthy submandibular salivary gland. Read More

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November 2018
5 Reads

Apocrine gland-rich skin has a non-inflammatory IL-17 related immune milieu, which turns to inflammatory IL-17 mediated disease in hidradenitis suppurativa.

J Invest Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

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October 2018
4 Reads

Mechanical Stress as a Cause of Hidradenitis Suppurativa: A Lesson from a Patient with a Monster Hernia.

Acta Dermatovenerol Croat 2018 Oct;26(3):260-261

Valerio De Vita, MD, Young Dermatologists Italian Network (YDIN) Study Center of the Italian Group for Epidemiologic Research in Dermatology (GISED), Via Clara Maffei 4, 24121 Bergamo , Italy;

We have read with great interest the case report recently published in Acta Dermatovenerologica Croatica by Boer and Mihajlovic (1), which describes a 33-year-old woman with an 18-year history of classic hidradenitis suppurativa (HS) who developed HS-like lesions at the position of the bra strap. We agree with Boer and Mihajlovic: according to our clinical experience, we are convinced that mechanical stress may contribute or, in some cases, result in the development of HS. In this regard, we will describe the case of a patient with a monster hernia who presented HS-like lesions on his abdomen corresponding to the perihernial skin area, suggesting that mechanical stress was an important pathogenic factor for HS development. Read More

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October 2018
1 Read

Different immunohistochemical localization for TMEM16A and CFTR in acinar and ductal cells of rat major salivary glands and exocrine pancreas.

Acta Histochem 2018 Oct 30. Epub 2018 Oct 30.

Department of Anatomy (Cell Biology), Iwate Medical University, Yahaba, Japan.

We investigated the mRNA expression and immunohistochemical localization of Cl channels, transmembrane member 16A (TMEM16A or anoctamin 1), and cystic fibrosis transmembrane conductance regulator (CFTR) in rat major salivary glands and exocrine pancreas. RT-PCR detected mRNA expression of TMEM16A and CFTR in the extracts of the parotid gland (PG), submandibular gland (SMG), sublingual gland (SLG), and pancreas. Immunoreactivity for TMEM16A was localized in the apical membrane of serous acinar and intercalated ductal cells in the PG and SMG as well as mucous acinar cells in the SLG; however, it was not detected in striated ductal cells of these tissues. Read More

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October 2018

Male Breast Cancer: A Rare Entity.

JNMA J Nepal Med Assoc 2018 Jul-Aug;56(212):804-807

Department of Pathology, B P Koirala Institute of Health Sciences, Dharan, Nepal.

Male breast carcinoma is a rare malignancy (<1% of all breast carcinomas, 0.2% of all male malignancies). Its common histopathological type is infiltrating carcinoma, not otherwise specified. Read More

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November 2018
2 Reads

Detection of a metallic foreign body in the Wharton duct: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e12939

Foshan Stomatology Hospital, School of Stomatology and Medicine, Foshan University, Foshan, Guangdong, P.R. China.

Rationale: Foreign bodies are rarely found in the submandibular gland and the Wharton duct, due to their physiological and anatomical features.

Patient Concerns: A 23-year-old man was referred to Foshan Stomatology Hospital in July 2016, with pain and intermittent swelling in the right submandibular area.

Diagnoses: Physical examination revealed enlarged, indurated, and painful swelling in the right submandibular area, with a normal oral cavity. Read More

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November 2018
2 Reads

Protein 14-3-3ε Regulates Cell Proliferation and Casein Synthesis via PI3K-mTOR Pathway in Dairy Cow Mammary Epithelial Cells.

J Agric Food Chem 2018 Nov 6;66(45):12000-12008. Epub 2018 Nov 6.

College of Life Science and Technology , Dalian University, Dalian Economic Technological Development Zone , Dalian , Liaoning 116622 , China.

Cell proliferation and casein synthesis of dairy cow mammary epithelial cells (DCMECs) are regulated by many factors. This research aimed to investigate the effect of 14-3-3ε on cell proliferation and casein synthesis in DCMECs and to reveal the underlying mechanism. Overexpressing or inhibiting 14-3-3ε demonstrated that cell proliferation; casein synthesis; expression of mTOR, p-mTOR, S6K1, and p-S6K1; and lysosomal localization of mTOR were all up-regulated by 14-3-3ε overexpressing and down-regulated by 14-3-3ε inhibiting. Read More

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November 2018
6 Reads

A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?

Diagn Cytopathol 2018 Oct;46(10):859-863

Unit of Molecular Pathology, IPATIMUP, Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

Background: Recently a new system for reporting salivary gland fine-needle aspiration (FNA) cytology was proposed, the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Herein, we evaluated diagnostic accuracy of salivary gland FNA, comparing the system previously used in our hospital with the Milan system.

Methods: Salivary gland specimens obtained between 2011 and 2017 were reclassified according to MSRSGC. Read More

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October 2018
7 Reads

Enhancing abiraterone acetate efficacy in androgen receptor-positive triple negative breast cancer: Chk1 as a potential target.

Clin Cancer Res 2018 Oct 23. Epub 2018 Oct 23.

UNIT U1218, Institut National de la santé et de la recherche médicale (INSERM), Institut Bergonié.

Purpose: Our aim was to identify predictive factors of abiraterone acetate (AA) efficacy and putative new druggable targets in androgen receptor (AR)-positive triple-negative breast cancer (TNBC) treated in the UCBG 2012-1 trial.

Experimental Design: We defined AA response as either complete or partial response, or stable disease at 6 months. We sequenced 91 general and breast cancer-associated genes from the tumor DNA samples. Read More

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October 2018
6 Reads

Hyaline Cell-Rich Apocrine Mixed Tumor with Cytologic Atypia.

Authors:
Chika Ohata

Dermatopathology (Basel) 2018 Jul-Sep;5(3):108-112. Epub 2018 Sep 13.

Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.

Hyaline cell-rich apocrine mixed tumor is relatively rare, and it often possesses atypical cells. Despite the presence of atypical cells, other histopathological features such as well circumscription, smooth border, predominance of bland cells, and no mitotic figures lead to classify these tumors as benign. In addition, no recurrence or metastasis has been reported even when cytologic atypia is identified. Read More

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September 2018

Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, .

Viruses 2018 10 18;10(10). Epub 2018 Oct 18.

Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.

The transmission cycle of chikungunya virus (CHIKV) requires that mosquito vectors get persistently infected with the virus, following its oral acqsuisition from a vertebrate host. The mosquito midgut is the initial organ that gets infected with orally acquired CHIKV. Following its replication in the midgut epithelium, the virus exits the midgut and infects secondary tissues including the salivary glands before being transmitted to another host. Read More

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October 2018
2 Reads

Rotationally resliced 3D prostate segmentation of MR images using Bhattacharyya similarity and active band theory.

Phys Med 2018 Oct 28;54:56-65. Epub 2018 Sep 28.

Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, China; Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Shanghai, China. Electronic address:

Purpose: In this article, we propose a novel, semi-automatic segmentation method to process 3D MR images of the prostate using the Bhattacharyya coefficient and active band theory with the goal of providing technical support for computer-aided diagnosis and surgery of the prostate.

Methods: Our method consecutively segments a stack of rotationally resectioned 2D slices of a prostate MR image by assessing the similarity of the shape and intensity distribution in neighboring slices. 2D segmentation is first performed on an initial slice by manually selecting several points on the prostate boundary, after which the segmentation results are propagated consecutively to neighboring slices. Read More

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October 2018

Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands.

Int J Mol Sci 2018 Oct 17;19(10). Epub 2018 Oct 17.

Department of Diagnostic & Biomedical Sciences, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX 77054, USA.

Every day, salivary glands produce about 0.5 to 1.5 L of saliva, which contains salivary proteins that are essential for oral health. Read More

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October 2018
4 Reads

Diagnostic performance of PCA3 and hK2 in combination with serum PSA for prostate cancer.

Medicine (Baltimore) 2018 Oct;97(42):e12806

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road.

Objectives: The prostate cancer gene 3 (PCA3), human kallikrein 2, and miRNA-141 are promising prostate cancer (Pca) specific biomarkers. Our aim was to evaluate the detection of PCA3, human glandular kallikrein 2 (hk2), and miRNA-141 mRNA in peripheral blood of patients received prostate biopsy. What's more, we want to detect the value of combination of PSA (prostate specific antigen) in the early diagnosis of PCa. Read More

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October 2018
5 Reads
5.720 Impact Factor

From Molecular Mechanism to the Etiology of Sjogren Syndrome.

Curr Pharm Des 2018 Oct 16. Epub 2018 Oct 16.

Dept. of Prosthodontics, Dental Hospital, Jilin University, Changchun, Jilin 130021. China.

Sjogren's Syndrome (SS) is a chronic, female overwhelming fundamental issue of an immune system rheumatic sickness that influences the whole body. It is described by lymphocytic invasion of the exocrine viz. salivary and lacrimal glands and by surprising B-cell hyperactivity. Read More

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October 2018
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Comparison of the histology of the skin of the Windsnyer, Kolbroek and Large White pigs.

J S Afr Vet Assoc 2018 Sep 25;89(0):e1-e10. Epub 2018 Sep 25.

School of Physiology, University of the Witwatersrand.

The skin is a protective barrier, and an endocrine, sensory and thermoregulatory organ. We investigated whether the skin of local pigs had beneficial anatomical traits compared to exotic pigs to withstand the increased heat loads predicted under future climate change scenarios. Full-thickness skin specimens were obtained from the dorsal interscapular, lateral thoraco-abdominal and ventral abdominal regions of intact boars (age 6-8 months) of two local breeds of pigs (Windsnyer [n = 5] and Kolbroek [n = 4]) and an exotic pig breed (Large White [n = 7]). Read More

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September 2018
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Outcome of Pedicled Thoracodorsal Artery Perforator Flap in the Surgical Treatment of Stage II and III Hidradenitis Suppurativa of Axilla.

Ann Plast Surg 2018 Dec;81(6):688-693

From the Faculty of Medicine, Benha University, Benha, Egypt.

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory disease affecting the apocrine glands of the axillary, groin, and mammary regions with significant physical and psychosocial sequelae. Surgical excision of the affected tissue is the criterion standard treatment. Advanced cases of axillary HS are associated with high rates of recurrence and require extensive surgical resection with challenging reconstruction associated with risk of postoperative complications. Read More

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December 2018
3 Reads