4,311 results match your criteria Apmis[Journal]


BRAF mutation, TERT promoter mutation, and HER2 amplification in sporadic or Neurofibromatosis related neurofibromas and malignant peripheral nerve sheath tumors: Do these molecules have a signature in malignant transformation?

APMIS 2020 Jun 24. Epub 2020 Jun 24.

Departments of Pathology and Cytology, Duzce University, Konuralp Campus, Duzce, Turkey.

Benign (BPNSTs) and malignant peripheral nerve sheath tumors (MPNSTs) can occur either sporadically or related to neurofibromatosis (NF) syndromes (1). While sporadic neurofibromas are benign, some neurofibromas related to neurofibromatosis can transform to MPNSTs. It suggests that the biological behaviour of both neurofibromas may change due to different genetic mutations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13063DOI Listing

Subtyping of male breast cancer by PAM50 and immunohistochemistry; a pilot study of a consecutive Danish cohort.

APMIS 2020 Jun 24. Epub 2020 Jun 24.

Research Unit of Pathology, Department of Clinical Research, University of South, Sonderborg, Denmark.

Male breast cancer (MBC) is a rare disease that is still to be fully understood. In female breast cancer molecular subtyping by gene expression has proven its significance. In this study we characterize a consecutive cohort of MBC patients surgically treated from 1997-2017, identified at our institution (N=37), and report the association between molecular subtypes found by a surrogate panel of immunohistochemical (IHC) markers, and the PAM50 signature, as well as Risk-Of-Recurrence score and overall survival for the different subtypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13068DOI Listing

IgG4-positive plasma cells in Hashimoto thyroiditis: IgG4-related disease or inflammation-related IgG4-positivity?

APMIS 2020 Jun 23. Epub 2020 Jun 23.

Pathology, Fimlab Laboratories, Tampere, Finland.

Despite the interest of researchers in IgG4-related disease (IgG4-RD), many questions still remain unanswered regarding the thyroid gland. We aimed to clarify the relationship between IgG4-positive plasma cells and the histopathological pattern in the Hashimoto thyroiditis (HT) in a Finnish series. HT specimens (n = 280) were retrieved from the Department of Pathology, Fimlab Laboratories. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13067DOI Listing

A case of false-positive pneumococcal urinary antigen test in a bacteremic Streptococcus agalactiae infection.

APMIS 2020 Jun 21. Epub 2020 Jun 21.

Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.

Pneumonia due to Streptococcus pneumoniae is a major cause of disease requiring treatment and hospitalization (1,2). The standard procedure for confirming pneumococcal pneumonia is positive culture of S. pneumoniae from blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13066DOI Listing

Nephrotic syndrome and pulmonary hypertension as complications of intravenous drug abuse.

APMIS 2020 Jun 21. Epub 2020 Jun 21.

Departments of Internal Medicine, Ålesund Hospital, Ålesund, Norway.

This case report discusses a patient with nephrotic syndrome, pulmonary hypertension and repeated episodes of infections. He had a history of intravenous drug abuse. Kidney biopsy revealed the rare finding of numerous foam cells, mainly in glomeruli. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13065DOI Listing

Thyroid cancer metastasis is associated with an overabundance of defective follicular helper T cells.

APMIS 2020 Jun 20. Epub 2020 Jun 20.

Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Metastatic thyroid cancers are more difficult to treat and have a significantly worse prognosis than localized thyroid cancers. Previous studies have shown that follicular helper T cells (Tfh) may participate in antitumor immune responses. Here, we investigated the characteristics of Tfh cells in patients with differentiated thyroid cancer (DTC) at various severities, including patients with localized disease, cervical metastasis, and distant metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13062DOI Listing

Performance analysis of high-throughput HPV testing on three automated workflows.

APMIS 2020 Jun 19. Epub 2020 Jun 19.

Pathologie-DNA, Location Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.

Primary high risk human papillomavirus (hrHPV) DNA testing has been introduced in several countries worldwide, including The Netherlands. The objective of this study was to compare 3 automated workflow procedures for hrHPV testing of which the hrHPV detection assays meet the international guidelines for HPV testing. To mimic a realistic screening situation, we aimed to process 15,000 residual PreservCyt cervical samples in a period of 3 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13064DOI Listing

Prevention of nosocomial Acinetobacter baumannii infections with a conserved immunogenic fimbrial protein.

APMIS 2020 Jul 9;128(7):476-483. Epub 2020 Jun 9.

Department of Biotechnology, Semnan University, Semnan, Iran.

Acinetobacter baumannii, one of the most life-threatening nosocomial drug-resistant pathogens, imposes high morbidity and mortality rates, thus highlighting immunization-based treatments or prevention measures. The selection of appropriate antigens can elicit protective immunity. The gene encoding a fimbrial protein introduced via reverse vaccinology was cloned, expressed and evaluated for immunogenicity in a murine model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13061DOI Listing

Genomic epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates from Ukraine, 2013-2018.

APMIS 2020 Jul;128(7):465-475

WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major health threat compromising the gonorrhoea treatment globally. AMR surveillance including whole genome sequencing (WGS)-based epidemiology provides ideal resolution to identify and describe AMR gonococcal clones, AMR determinants and populations, which can inform management guidelines and antimicrobial stewardship policies. Our aims were to, for the first time, elucidate the WGS-based epidemiology and characterize AMR determinants of gonococcal strains spreading in Ukraine, 2013-2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13060DOI Listing
July 2020
1.922 Impact Factor

Studies on viral pneumonia related to novel coronavirus SARS-CoV-2, SARS-CoV, and MERS-CoV: a literature review.

APMIS 2020 Jun;128(6):423-432

Department of Respiratory, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.

Coronaviruses are a class of RNA viruses that can cause respiratory and intestinal infections in animals and humans. SARS-CoV, MERS-CoV, and a novel coronavirus (SARS-CoV-2 [2019-nCoV]) belong to the family Coronaviridae and the genus Betacoronavirus. At present, the understanding of SARS-CoV-2 is getting deeper and deeper. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13047DOI Listing
June 2020
1.922 Impact Factor

Epidemiology of bacteria and viruses in the respiratory tract of humans and domestic pigs.

APMIS 2020 Jun;128(6):451-462

Institute for Infection Medicine, Christian-Albrecht University of Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

Bacteria and viruses were analysed in the upper respiratory tract of symptomatic pig farmers and their domestic pigs. Eighty six human nasal and 495 (50 pools) porcine snout swabs were collected in Schleswig-Holstein, Germany. Staphylococcus (S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13046DOI Listing

Epidemiology and role of Helicobacter pylori virulence factors in gastric cancer carcinogenesis.

APMIS 2020 Feb;128(2):150-161

Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Infection with Helicobacter pylori is associated with the development of gastric cancer. Although the prevalence of gastric cancer has declined throughout years due to improvement in early screening strategy, mortality due to gastric cancer has not changed. Incidence and mortality due to gastric cancer are higher in developing countries as compared to developed countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13034DOI Listing
February 2020

Programmed cell death protein 1 (PD-1) in infection.

APMIS 2020 Feb;128(2):177-187

Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Exhausted and dysfunctional T cells triggered by infection and cancer render the immune system unable to eliminate these pathogens. Pharmacologic blockade of the surface receptors that inhibit T-cell function has shown remarkable success in patients with various malignancies. In this Review, we discuss the emerging evidence of inhibiting checkpoint pathways as a potential role in controlling or clearing infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13045DOI Listing
February 2020

Eradication of biofilms on tympanostomy tubes with acetic acid treatment: an in vitro study.

APMIS 2020 Jun 4;128(6):445-450. Epub 2020 May 4.

Costerton Biofilm Center, University of Copenhagen, Copenhagen N, Denmark.

The purpose was to evaluate the eradicative effect of acetic acid on bacterial biofilm grown on tympanostomy tubes by an in vitro experiment. Biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown on sterile tympanostomy tubes for 24 h. The tubes were treated with acetic acid solutions at various concentrations for 24 h. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13044DOI Listing

A Chlamydia trachomatis 23S rRNA G1523A variant escaping detection in the Aptima Combo 2 assay (Hologic) was widespread across Denmark in July-September 2019.

APMIS 2020 Jun 4;128(6):440-444. Epub 2020 May 4.

Department for Bacteria, Parasites and Fungi, Infectious Diseases Preparedness, Statens Serum Institut, Copenhagen, Denmark.

Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection globally, and nucleic acid amplification tests (NAATs) are recommended for highly sensitive and specific diagnosis. In early 2019, the Finnish new variant of Chlamydia trachomatis (FI-nvCT) was identified. The FI-nvCT has a C1515T mutation in the 23S rRNA gene, making it escaping detection in the Aptima Combo 2 (AC2; Hologic) NAAT, and the FI-nvCT has been subsequently reported in Sweden and Norway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13043DOI Listing

The contribution of HERV-E clone 4-1 and other HERV-E members to the pathogenesis of rheumatic autoimmune diseases.

APMIS 2020 May 30;128(5):367-377. Epub 2020 Apr 30.

Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.

Human endogenous retroviruses (HERV)-E consist of a family of more than 1300 elements, stably integrated in the human genome. Some of them are full-length proviruses able to synthesize the viral proteins gag, pol and env. The reactivation of HERV-E elements has been associated to placentation, cancer and autoimmunity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13039DOI Listing

Putative anoikis-resistant subpopulations in colorectal carcinoma: a marker of adverse prognosis.

APMIS 2020 May 27;128(5):390-400. Epub 2020 Apr 27.

Department of Pathology, Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.

Anoikis is a form of apoptosis induced when a cell loses contact with the extracellular matrix (ECM). Anoikis resistance is essential for metastasis formation, yet only detectable by in vitro experiments. We present a method for quantitation of putative anoikis-resistant (AR) subpopulations in colorectal carcinoma (CRC) and evaluate their prognostic significance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13041DOI Listing

Evaluation of a semi-automated Seegene PCR workflow with MTB, MDR, and NTM detection for rapid screening of tuberculosis in a low-prevalence setting.

APMIS 2020 May 27;128(5):406-413. Epub 2020 Apr 27.

Department of Clinical Microbiology, Fimlab Laboratories, Tampere, Finland.

In areas of low tuberculosis (TB) prevalence, laboratory diagnosis of TB may essentially cover non-tuberculous mycobacteria (NTM) in addition to Mycobacterium tuberculosis (MTB). In this study, a semi-automated PCR workflow distinguishing MTB and NTM (Anyplex™ MTB/NTMe, Seegene) and subsequently detecting MTB isoniazid/rifampicin resistance (Allplex™ MTB/MDRe, Seegene) was evaluated for replacing smear microscopy of acid-fast bacilli as the rapid screening method for TB. With 279 clinical samples, 47 cultures positive for MTB and 76 for NTM, the Anyplex™ MTB/NTMe assay and smear microscopy showed equal sensitivities (49. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13040DOI Listing

Oral symptoms and pathologies in Danish patients with chronic kidney disease- a pilot study.

APMIS 2020 May 27;128(5):401-405. Epub 2020 Apr 27.

Oral Pathology and Medicine, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

The aim was to investigate oral health in randomly selected patients with chronic kidney disease (CKD). Data obtained by structured interview (self-reported lifestyle, oral symptoms and regularity of dental visits) and oral examination of patients with CKD from the Copenhagen University Hospital. Fourteen patients with CKD were screened. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13042DOI Listing

Endemic Burkitt lymphoma - an aggressive childhood cancer linked to Plasmodium falciparum exposure, but not to exposure to other malaria parasites.

APMIS 2020 Feb 4;128(2):129-135. Epub 2020 Mar 4.

Centre for Medical Parasitology at Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma. The prevalence of BL is ten-fold higher in areas with stable transmission of Plasmodium falciparum malaria, where it is the most common childhood cancer, and is referred to as endemic BL (eBL). In addition to its association with exposure to P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13018DOI Listing
February 2020

Minimal residual disease monitoring cannot fully replace bone marrow morphology in assessing disease status in pediatric acute lymphoblastic leukemia.

APMIS 2020 May 25;128(5):414-419. Epub 2020 Mar 25.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.

Minimal residual disease (MRD) monitoring has a strong prognostic value in childhood lymphoblastic leukemia (ALL) and is currently utilized in all major pediatric ALL protocols. MRD monitoring is done by multiparameter flow cytometry, IG/TCR quantitative PCR or reverse transcriptase quantitative PCR of leukemic fusion transcripts providing a reliable measurement of treatment response. However, occasionally bone marrow (BM) aspirates may not yield representative material or be misinterpreted due to treatment-induced changes in MRD marker profile, undetected subclones at diagnosis, contamination with peripheral blood or cell adhesion and stroma cell interactions posing a risk for underestimating MRD levels and misclassifying resistant disease that may be detected by traditional BM morphology methods, immunohistochemistry, karyotyping and FISH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13037DOI Listing

Gut microbiota in atherosclerosis: focus on trimethylamine N-oxide.

APMIS 2020 May 30;128(5):353-366. Epub 2020 Mar 30.

Department of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

The increasing prevalence of cardiovascular diseases cannot adequately be explained by traditional risk factors. Recently, accumulating evidence has suggested that gut microbiota-derived numerous metabolites are contributors to atherosclerotic events. Among them, the role of trimethylamine N-oxide (TMAO) in promoting atherosclerosis has gained attention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318354PMC

Antisecretory factor AF-16 improves vascular access to a rat mammary tumour.

APMIS 2020 May;128(5):387-389

Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Tumor tissue often has an insufficient nutritional supply, in part due to compression of the vascular network from an increased interstitial fluid pressure. We have shown that the antisecretory factor peptide AF-16 can reduce this pressure in experimental rat breast tumors. In this work we studied if AF-16 administration opened up to an increased vascular volume in these tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13036DOI Listing

Clinicopathologic features and prognostic factors in patients with renal cell carcinoma with sarcomatoid differentiation.

APMIS 2020 May 27;128(5):378-386. Epub 2020 Apr 27.

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Renal cell carcinoma with sarcomatoid differentiation (RCCs) is rare, accounting for 1-8% of all RCC histological subtypes. In this study, we examined 139 patients with RCCs and aimed to explore their clinicopathologic features and prognostic factors. From January 2007 to January 2019, patients who were pathologically diagnosed with RCCs were included in this retrospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13035DOI Listing

The impact of the gut microbiota on prognosis after surgery for colorectal cancer - a systematic review and meta-analysis.

APMIS 2020 Feb;128(2):162-176

Center for Surgical Science, Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.

The aim of this study was to conduct a systematic review of the association between gut microbiota and prognosis after colorectal cancer surgery. The review was conducted according to the PRISMA guidelines. A systematic literature search was conducted in PubMed, Embase, and Scopus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13032DOI Listing
February 2020

Can vancomycin lock therapy extend the retention time of infected long-term catheters?

APMIS 2020 Jun 4;128(6):433-439. Epub 2020 May 4.

Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

We assessed the success rate of vancomycin catheter lock therapy (VLT) in combination with systemic antimicrobials in patients with staphylococcal catheter-related bloodstream infection (C-RBSI). Over a 6-year period, we retrospectively collected clinical and microbiological data from patients with long-term central venous catheters and staphylococcal C-RBSI who were treated with systemic antimicrobials and VLT. We then assessed the success rate of VLT based on two criteria: 1) catheter retention time> 3 months and 2) catheter in place until end of use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13033DOI Listing

The role of infectious agents in cancer of the ocular region.

APMIS 2020 Feb 30;128(2):136-149. Epub 2020 Jan 30.

Eye Pathology Section, Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13017DOI Listing
February 2020

Tumour angiogenesis and c-Met pathway activation - implications in breast cancer.

APMIS 2020 Apr 27;128(4):316-325. Epub 2020 Feb 27.

Department of General Surgery, PGIMER, Chandigarh, India.

Breast cancer is a heterogeneous disease with wide range of clinical behaviour. Tumour angiogenesis and metastasis have been considered as prognostic markers of the breast carcinoma, and c-Met, a transmembrane receptor tyrosine kinase has been implicated in both these processes of tumour progression. This study was conducted to elucidate c-Met and downstream signalling pathways in breast cancer and correlate with angiogenesis as assessed by microvessel density (MVD) and other prognostic parameters including lymph node metastases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13031DOI Listing
April 2020
1.922 Impact Factor

Infection and the role in cancer development.

APMIS 2020 02 18;128(2):71. Epub 2020 Mar 18.

Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13030DOI Listing
February 2020

EZH2 expression is dependent on MYC and TP53 regulation in diffuse large B-cell lymphoma.

APMIS 2020 Apr 27;128(4):308-315. Epub 2020 Feb 27.

LABGEM, Departamento de Patologia e Medicina Legal, Universidade Federal Do Ceará, Fortaleza, Brazil.

EZH2 is an important epigenetic regulator, but its role in diffuse large B-cell lymphoma (DLBCL) pathogenesis and its relationship with MYC, BCL2, and TP53 expression, chromosomal rearrangements, and clinical features are still poorly understood. So, we investigated EZH2 expression and its associations with the immunophenotypic presentations, including MYC, BCL2, and TP53 expression, MYC, BCL2, and BCL6 translocation status, clinicopathological features, and therapeutic response to R-CHOP in a series of 139 DLBCL cases. EZH2 positivity was associated with MYC and TP53 expression (p = 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13029DOI Listing

Human papillomavirus and urinary bladder cancer revisited.

APMIS 2020 Feb 28;128(2):72-79. Epub 2020 Jan 28.

Department of Urology, Aarhus University Hospital, Aarhus, Denmark.

This review aims to present data on the association between human papillomavirus (HPV) and urinary bladder cancer (BC), especially of the subtype squamous cell carcinoma (SCC). Furthermore, the current data on the relation between p16, HPV, and BC are reviewed. PubMed was searched for 'Humans' [MESH] AND 'Papillomaviridae' [MESH] AND 'Urinary Bladder Neoplasms' [MESH], resulting in 157 potential articles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13016DOI Listing
February 2020

Bacterial signatures and their inflammatory potentials associated with prostate cancer.

APMIS 2020 Feb 28;128(2):80-91. Epub 2020 Jan 28.

Institute of Biotechnology, Department of Applied Biochemistry, Technical University of Berlin, Berlin, Germany.

Chronic inflammation can create a microenvironment that can contribute to the formation of prostate pathologies. Far less well understood is the origin of inflammation in the prostate. One potential source is microbial infections of the prostate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13021DOI Listing
February 2020

Merkel cell polyomavirus and non-Merkel cell carcinomas: guilty or circumstantial evidence?

APMIS 2020 Feb 28;128(2):104-120. Epub 2020 Jan 28.

Molecular Inflammation Research Group, Department of Medical Biology, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.

Merkel cell polyomavirus (MCPyV) is the major causative factor of the rare but aggressive cancer, Merkel cell carcinoma (MCC). Two characteristics of MCPyV-positive MCCs are integration of the viral genome and expression of a truncated version of one of its oncogenic proteins, namely large T antigen. The strong association of MCPyV with MCC development has incited researchers to further investigate a possible role of this virus in other cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13019DOI Listing
February 2020
1.922 Impact Factor

Cancer during HIV infection.

APMIS 2020 Feb 28;128(2):121-128. Epub 2020 Jan 28.

Department of Infectious Diseases Immunology, Statens Serum Institut, Copenhagen, Denmark.

HIV+ persons have a significantly increased risk of cancer when compared to the general population. The excess cancer risk observed during HIV infection is particularly higher for infection-related malignancies. Mechanisms underlying this remain unclear, but both HIV-related and HIV-unrelated factors have been postulated to play a role. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13020DOI Listing
February 2020

The inflammatory response to bone infection - a review based on animal models and human patients.

APMIS 2020 Apr 14;128(4):275-286. Epub 2020 Feb 14.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.

Bone infections are difficult to diagnose and treat, especially when a prosthetic joint replacement or implant is involved. Bone loss is a major complication of osteomyelitis, but the mechanism behind has mainly been investigated in cell cultures and has not been confirmed in human settings. Inflammation is important in initiating an appropriate immune response to invading pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13027DOI Listing

Hierarchical clustering of PI3K and MAPK pathway proteins in breast cancer intrinsic subtypes.

APMIS 2020 Apr 27;128(4):298-307. Epub 2020 Feb 27.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

The phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways are frequently activated in breast cancer. We recently demonstrated the importance of analyzing multiple proteins as read-out for pathway activation in ER+/HER2- breast cancer, since single proteins are known to provide insufficient information. Here, we determined pathway activation in other primary breast cancer intrinsic subtypes derived from postmenopausal patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317370PMC

Association of toll-like receptor 10 polymorphisms with pediatric pneumococcal meningitis.

APMIS 2020 Apr 27;128(4):335-342. Epub 2020 Feb 27.

Department of Medical Microbiology, Capital Medical University, Beijing, China.

We aimed to investigate whether the gene polymorphisms of TLR10 were associated with risk and severity of pneumococcal meningitis (PM) and serum cytokine levels in children. Three single nucleotide polymorphisms (SNPs) of TLR10 rs4129009 (2676A > G), rs10004195 (1018T > A) and rs11466617 (40735A > G) were studied in 95 laboratory-confirmed PM pediatric patients and 330 healthy controls by PCR-based sequencing. Ten serum cytokines were determined by multiplex immunoassay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13028DOI Listing

Comparative evaluation of CLIA and EIA for Quantiferon-TB Gold Plus.

APMIS 2020 Apr 2;128(4):343-349. Epub 2020 Mar 2.

Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.

The purpose of this study was to compare the Quantiferon-TB Gold Plus test analysed with chemiluminescence immunoassay (CLIA) to immunoassay (EIA). One hundred and twenty-five clinical specimens submitted to Karolinska University Hospital for Quantiferon-TB Gold Plus analysis were used to analyse agreement of the CLIA and EIA assays. The imprecision on CLIA was determined by analysis of pooled clinical samples of antigen tubes (TB1 and TB2), a reference material from National Institute for Biological Standards and Control (NIBSC 82/587) and two controls of the test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13025DOI Listing

Expression of TRIM22 mRNA in chronic hepatitis C patients treated with direct-acting antiviral drugs.

APMIS 2020 Apr 28;128(4):326-334. Epub 2020 Jan 28.

Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan.

Hepatitis C is a global public health problem, and Pakistan is the second largest country in the globe with highest prevalence rate of hepatitis C virus (HCV). Until 2014, pegylated interferon (PEG-IFN) plus ribavirin (RBV) has been the standard therapy for HCV, however, owing to its adverse side effects and very low sustained virologic response (SVR) rates therapeutics trend is shifted toward direct-acting antivirals. Tripartite motif containing 22 (TRIM22) is a dynamic antiviral protein that can inhibit multiple viruses in vivo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13024DOI Listing
April 2020
1.922 Impact Factor

Expression and prognostic utility of SSX2IP in patients with nasopharyngeal carcinoma.

APMIS 2020 Apr 29;128(4):287-297. Epub 2020 Jan 29.

Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Cell adhesion affects carcinogenesis, tumor progression, and metastasis. We datamined a published transcriptome (GSE12452) of nasopharyngeal carcinoma (NPC) and identified SSX2IP as a significantly upregulated gene in NPC carcinogenesis among genes associated with cell adhesion (GO:0007155). Consequently, we assessed SSX2IP protein expression and its prognostic significance in 124 patients with NPC using immunohistochemistry and the H-score method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13023DOI Listing

The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs.

APMIS 2020 Mar 28;128(3):242-250. Epub 2020 Jan 28.

WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Treatment options for gonorrhoea are scarce. Drug repurposing of bioactive molecules approved for other conditions might therefore be of value. We developed a method for wide-scale, systematic drug repurposing screen to identify molecules with activity against Neisseria gonorrhoeae and screened the Prestwick Chemical Library (1200 FDA-approved drugs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13014DOI Listing

Composition and plasticity of triple-negative breast carcinoma-infiltrating regulatory T cells.

APMIS 2020 Mar 28;128(3):260-269. Epub 2020 Jan 28.

Breast-Thyroid Surgery Department, Shengli Oilfield Central Hospital, Dongying, China.

Low Foxp3 regulatory T-cell (Treg) presence in the tumor-infiltrating lymphocytes (TILs) is considered favorable in breast cancer, and numerous CD25-targeting agents have been applied in the attempt to remove Foxp3 Treg cells, which typically present CD4 CD25 surface phenotype. However, CD25 is not Treg-exclusive and can be upregulated by effector T cells. Hence, CD25 depletion may cause the elimination of activated T cells that are responding to tumor-specific antigens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13022DOI Listing

Quercetin inhibits carbapenemase and efflux pump activities among carbapenem-resistant Gram-negative bacteria.

APMIS 2020 Mar 3;128(3):251-259. Epub 2020 Jan 3.

Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, India.

Rapid dissemination of carbapenem-resistant Gram-negative bacteria (CRGNB) is a global threat. Quercetin is known for its antimicrobial activity. In this study, carbapenemase and efflux pump inhibitory activities of quercetin were demonstrated against carbapenem-resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13015DOI Listing

Microbial risk factors for treatment failure of pivmecillinam in community-acquired urinary tract infections caused by ESBL-producing Escherichia coli.

APMIS 2020 Mar 3;128(3):232-241. Epub 2020 Jan 3.

Department of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway.

The aim of this study was to identify microbial risk factors for treatment failure of pivmecillinam in community-acquired urinary tract infections (ca-UTIs) caused by ESBL-producing Escherichia coli. Eighty-nine ESBL-producing E. coli isolated from women suffering from ca-UTIs were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13013DOI Listing

Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study.

APMIS 2020 Mar 28;128(3):201-210. Epub 2020 Jan 28.

Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.

Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation and invasion, its increased activation is associated with cancer development as well. To get deeper insight into the behavior of Dishevelled proteins in cancer, we studied their expression in serous ovarian carcinomas [both low- (LGSC) and high-grade (HGSC)], and HGSC cell lines OVCAR5, OVCAR8, and OVSAHO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13012DOI Listing
March 2020
1.922 Impact Factor

Bacillus Calmette-Guérin immunotherapy for bladder cancer: a review of immunological aspects, clinical effects and BCG infections.

APMIS 2020 Feb 28;128(2):92-103. Epub 2020 Jan 28.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer has been used since 1976 when the first evidence of its ability to lower recurrence and progression rates was published. Today, BCG immunotherapy is the choice of care for high-grade non-muscle invasive bladder cancer (NMIBC) after transurethral resection. This article presents indications and procedure of BCG instillations, and outlines the effects on recurrence and progression of NMIBC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13011DOI Listing
February 2020

The environmental occurrence of Pseudomonas aeruginosa.

APMIS 2020 Mar 18;128(3):220-231. Epub 2019 Dec 18.

Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Pseudomonas aeruginosa is generally described as ubiquitous in natural settings, such as soil and water. However, because anecdotal observations and published reports have questioned whether or not this description is true, we undertook a rigorous study using three methods to investigate the occurrence of P. aeruginosa: We investigated environmental samples, analyzed 16S rRNA data, and undertook a systematic review and meta-analysis of published data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13010DOI Listing
March 2020
1.922 Impact Factor

Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.

Authors:
Andrea Palicelli

APMIS 2020 Mar 3;128(3):191-200. Epub 2020 Jan 3.

Pathology Unit, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.

Intraductal carcinomas (IDCs) are rare, not well-characterized salivary gland tumors. A systematic literature review of pure IDCs (without stromal invasion) of low-grade (LG-IDCs) or high-grade (HG-IDCs) was performed: IDCs were classified using the apocrine (AR+/S100-) vs intercalated (S100+/AR-) classification. Eighty-two LG-IDCs and 11 HG-IDCs were identified (84% parotid; 11% oral; 3% submandibular; 1% lacrimal; and 1% unknown). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13009DOI Listing

spoT-mediated stringent response influences environmental and nutritional stress tolerance, biofilm formation and antimicrobial resistance in Klebsiella pneumoniae.

APMIS 2020 Jan;128(1):48-60

Department of Basic Medical Sciences, The University of the West Indies, Mona, Jamaica.

Klebsiella pneumoniae is an important opportunistic pathogen with significant potential for virulence and multidrug resistance. Treatment failure often occurs because the pathogen may couple virulence and drug resistance with the stringent response. This study assessed the role of the spoT gene in environmental and nutritional stress tolerance, exopolysaccharide capsule production and biofilm formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13006DOI Listing
January 2020

Molecular and phenotypical investigation of ciprofloxacin resistance among Campylobacter jejuni strains of human origin: high prevalence of resistance in Turkey.

APMIS 2020 Jan;128(1):41-47

Microbiology and Infectious Disease Group, Swansea University Medical School, Swansea University, Swansea, UK.

Campylobacteriosis is one of the most frequently reported zoonoses worldwide. The well-documented increase in the ciprofloxacin resistance has increased the importance of rapid detection of the resistance. The incidence of ciprofloxacin resistance was investigated using real-time PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apm.13005DOI Listing
January 2020