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    How social media meet patients’ questions: YouTube™ review for mouth sores in children.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):117-121
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    Recurrent aphthous stomatitis (RAS) is one of the most common causes of mouth sores in children so the management of this condition is a matter of great importance. YouTube™ is increasingly being used by patients to obtain health-related information. The aim of this work is to examine the quality of information offered by YouTube™ about mouth sores in children (MSC). Read More

    Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity.
    Gene 2018 Feb 16. Epub 2018 Feb 16.
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    Recurrent Aphthous Stomatitis (RAS) is a common oral inflammatory disease with unknown pathogenesis. Although the immune system alterations could be involved in predisposition of individuals to oral candidiasis, precise etiologies of RAS have not been understood yet. A recent study showed that autosomal dominant IL17F deficiency could cause chronic mucocutaneous candidiasis. Read More

    Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center.
    World J Clin Pediatr 2018 Feb 8;7(1):49-55. Epub 2018 Feb 8.
    Department of Medicine, Surgery and Health, University of Trieste, Trieste 34142, Italy.
    Aim: To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever (UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.

    Methods: Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever (HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis (PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes:(NM_000243. Read More

    Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report.
    Open Dent J 2018 29;12:19-23. Epub 2018 Jan 29.
    Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, SP. Brazil.
    Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman.

    Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. Read More

    Stomatitis associated with mammalian target of rapamycin inhibition: A review of pathogenesis, prevention, treatment, and clinical implications for oral practice in metastatic breast cancer.
    J Am Dent Assoc 2018 Feb 10. Epub 2018 Feb 10.
    Background: Patients with metastatic breast cancer may develop oral morbidities that result from therapeutic interventions. Mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis (mIAS) is a common adverse event (AE), secondary to mTOR inhibitor therapy, that can have a negative impact on treatment adherence, quality of life, and health care costs. A multidisciplinary team approach is important to minimize mIAS and to maximize treatment benefits to patients with breast cancer. Read More

    CD70 Deficiency due to a Novel Mutation in a Patient with Severe Chronic EBV Infection Presenting As a Periodic Fever.
    Front Immunol 2017 29;8:2015. Epub 2018 Jan 29.
    Clinica Pediatria e Reumatologia, Istituto Giannina Gaslini, Genova, Italy.
    Primary immunodeficiencies with selective susceptibility to EBV infection are rare conditions associated with severe lymphoproliferation. We followed a patient, son of consanguineous parents, referred to our center for recurrent periodic episodes of fever associated with tonsillitis and adenitis started after an infectious mononucleosis and responsive to oral steroid. An initial diagnosis of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome was done. Read More

    Association of the nod-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population.
    J Oral Pathol Med 2018 Feb 12. Epub 2018 Feb 12.
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes maybe involved. The aim of our study was to investigate three single nucleotide polymorphisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population.

    Methods: A total of 207 subjects were included in this case-control study. Read More

    Vitamin D status in recurrent aphthous stomatitis.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):612-617. Epub 2017 Dec 31.
    Department of Oral Mucosa Diseases, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease.

    Aim: To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism. Read More

    Association of IL-6-174 G/C and IL10-1082 G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis.
    Medicine (Baltimore) 2017 Dec;96(52):e9533
    Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
    Background: Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown etiology. The association between IL-6-174 G/C and IL10-1082 G/A polymorphisms and the risk of RAS remains controversial. Therefore, we conducted this meta-analysis to gain more evidence-based information. Read More

    Systemic bioinformatics analysis of recurrent aphthous stomatitis gene expression profiles.
    Oncotarget 2017 Dec 10;8(67):111064-111072. Epub 2017 Nov 10.
    Department of Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng 224006, Jiangsu, China.
    Recurrent aphthous stomatitis (RAS) represents the most common chronic oral diseases with the prevalence ranges from 5% to 25% for different populations. Its pathogenesis remains poorly understood, which limits the development of effective drugs and treatment methods. In this study, we conducted systemic bioinformatics analysis of gene expression profiles from the Gene Expression Omnibus (GEO) to identify potential drug targets for RAS. Read More

    Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis.
    J Formos Med Assoc 2018 Jan 12. Epub 2018 Jan 12.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

    The role of colchicine in the treatment of autoinflammatory diseases.
    Curr Pharm Des 2018 Jan 15. Epub 2018 Jan 15.
    Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens. Greece.
    Colchicine has been longstanding and widely used for the treatment of acute gout flares and prevention of gout relapses. Its use has been extended to a series of autoinflammatory diseases, such as familial Mediterranean fever and more recently to periodic fever with aphthous stomatitis, pharyngitis and adenitis, Behcet's disease and idiopathic recurrent acute pericarditis. In this review, we summarize current indications of colchicine use, discuss its pharmacokinetics and mechanism of action and examine its use in the treatment of autoinflammatory diseases. Read More

    Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration.
    Br Dent J 2018 Jan 12;224(2):70-71. Epub 2018 Jan 12.
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China School of Stomatology, Sichuan University Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University.
    In a clinical setting, it is not practical to separate recurrent aphthous stomatitis (RAS) from RAS-type ulceration in every case, so both conditions have been considered together for the purpose of this article. Due to the lack of consistently effective therapeutic options for RAS, other approaches to treat the disease are considered here, beginning with an analysis of possible aetiological factors. The aetiology of RAS, the most common mucosal disease, remains undefined thus far. Read More

    Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis.
    Acta Med Iran 2017 Nov;55(11):672-675
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
    This study has been conducted to evaluate the allele, genotype and haplotype frequencies of the polymorphic gene coding TGF-β in recurrent aphthous stomatitis (RAS). TGF-β gene typing was done by polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. Allele frequencies were estimated by direct gene counting. Read More

    Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis.
    Avicenna J Med Biotechnol 2018 Jan-Mar;10(1):56-60
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Recurrent Aphthous Stomatitis (RAS) is one of the most common diseases of the oral cavity all over the world (5-66%). RAS has a multifactorial etiology, while psychological factors such as stress and anger play a role in its manifestation. The serotonergic mechanisms particularly the serotonin-transporter gene () may affect the risk of psychological alterations and stress response. Read More

    Psychological factors in oral mucosal and orofacial pain conditions.
    Eur J Dent 2017 Oct-Dec;11(4):548-552
    Department of Oral Medicine and Oral Surgery, Faculty of Dentistry,University of Science and Technology, Irbid, Jordan.
    The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions (namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders) with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients. A literature search restricted to reports with highest relevance to the selected mucosal and orofacial pain conditions was carried out to retrieve data. Read More

    A case of adult-onset periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome in Japan.
    J Gen Fam Med 2017 Oct 2;18(5):261-264. Epub 2017 May 2.
    Department of Internal MedicineNagano Chuo HospitalNaganoJapan.
    Adult-onset periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is rare. We report the case of a 23-year-old woman with PFAPA syndrome in Japan. Her symptoms lasted for approximately 5 days in each period regardless of nonsteroidal anti-inflammatory drug or antibiotic treatment. Read More

    Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS).
    BMC Oral Health 2017 Dec 20;17(1):158. Epub 2017 Dec 20.
    Department of Gerodontology and Oral Pathology, University of Medical Sciences, ul. Bukowska 70, 60-812, Poznań, Poland.
    Background: Recurrent aphthous stomatitis (RAS) is an ulcerative disease of the oral mucosa without a clearly defined etiology. The aim of the study was to evaluate the serum zinc levels in patients with RAS in comparison to healthy controls and to validate the association between zinc levels and the course of RAS.

    Methods: Seventy-five patients with RAS and 72 controls underwent full dental examination. Read More

    Relative Efficacy of Quercetin Compared with Benzydamine Hydrochloride in Minor Aphthae: A Prospective, Parallel, Double Blind, Active Control, Preliminary Study.
    Int J Dent 2017 13;2017:7034390. Epub 2017 Nov 13.
    Oral Medicine and Radiology, A. J. Institute of Dental Sciences, Mangalore, India.
    Background And Objectives: Recurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. But complete eradication of the disease has not been possible and hence newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Read More

    Miscellaneous skin disease and the metabolic syndrome.
    Clin Dermatol 2018 Jan - Feb;36(1):94-100. Epub 2017 Sep 8.
    Department of Dermatology, Istanbul Medeniyet University, Medical School, Istanbul, Turkey. Electronic address:
    The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. Read More

    Oral Manifestations in Pediatric Patients with Coeliac Disease - A Review Article.
    Open Dent J 2017 24;11:539-545. Epub 2017 Oct 24.
    Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University, of Porto, Porto, Portugal.
    Background: Coeliac disease is a chronic enteropathy that remains a challenge for the clinician, due to its atypical manifestations and etiopathogenic complexity.

    Objective: This article intends to describe the oral characteristics of Coeliac Disease in children in order to facilitate their management in the dental office.

    Methods: A review of the literature was performed electronically in PubMed (PubMed Central, and MEDLINE) for articles published in English from 2000 to April of 2017. Read More

    Characteristics and Disease Course in a Cohort of Children With PFAPA Syndrome in the Community of Madrid, Spain.
    Reumatol Clin 2017 Dec 8. Epub 2017 Dec 8.
    Servicio de Enfermedades Infecciosas Pediátricas, Hospital General Universitario Gregorio Marañón, Madrid, España.
    Introduction: PFAPA syndrome is an autoinflammatory disease whose diagnosis is mainly clinical. Several treatments have been proposed; among them, tonsillectomy could be an effective one.

    Material And Methods: Retrospective multicenter study. Read More

    A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis.
    J Contemp Dent Pract 2017 Dec 1;18(12):1194-1197. Epub 2017 Dec 1.
    Department of Public Health Dentistry, Institute of Dental Education & Advance Studies (IDEAS), Gwalior, Madhya Pradesh, India.
    Aim: The aim of this study is to evaluate the association of Helicobacter pylori in recurrent aphthous stomatitis (RAS) with or without peptic ulcer.

    Materials And Methods: A total of 42 patients were selected for the present study from outpatient Department of Oral Medicine, and divided into control (group I) and test groups (groups II, III). A total number of 15 patients suffering from RAS based on history and clinical examination was selected as group II. Read More

    Recurrent Aphthous Stomatitis: An Assessment of Antioxidant Levels in Plasma and Saliva.
    J Clin Diagn Res 2017 Sep 1;11(9):ZC64-ZC67. Epub 2017 Sep 1.
    Manager, Department of Development Office, Christian Medical College, Vellore, Tamil Nadu, India.
    Introduction: Recurrent Aphthous Stomatitis (RAS) is a common oral mucosal disorder that affects 20% of the population worldwide. Factors such as trauma, stress, genetic, hypersensitivity, nutrition, immune disturbance and hormonal imbalance may disturb the oxidant and antioxidant balance of an organism and precipitate RAS, but the relationships are poorly understood.

    Aim: The purpose of this study was to evaluate the antioxidant status in plasma and saliva of patients with RAS. Read More

    Tooth Wear Is Frequent in Adult Patients with Celiac Disease.
    Nutrients 2017 Dec 4;9(12). Epub 2017 Dec 4.
    Department of Medicine, Surgery and Dentistry, Medical School of Salerno, 84131 Salerno, Italy.
    (1) Background: Celiac disease (CD) patients can be affected by mouth and tooth disorders, which are influenced by their gluten-free diet. The aim of our research was to evaluate the pathological conditions of the stomatognathic system observed in celiac patients on a gluten-free diet. (2) Methods: we consecutively recruited celiac patients on a gluten-free diet at our celiac center, as well as healthy volunteers. Read More

    Long-term follow-up of tonsillectomy efficacy in children with PFAPA syndrome.
    Braz J Otorhinolaryngol 2017 Nov 21. Epub 2017 Nov 21.
    Umraniye Training and Research Hospital, Department of Otolaryngology, Istanbul, Turkey.
    Introduction: The role of tonsillectomy in the periodic fever, aphthous stomatitis, pharyngitis, and adenitis, PFAPA syndrome, is controversial. Although some studies reported high success rates with tonsillectomy, further investigations are needed with larger numbers of patients.

    Objective: To seek the long-term outcomes of tonsillectomy in PFAPA syndrome. Read More

    Clinical evaluation of a toothpaste containing lysozyme for the treatment of recurrent aphthous stomatitis: A 3-month, double-blind, randomized study.
    Am J Dent 2016 Dec;29(6):303-306
    Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
    Purpose: To assess the efficacy and safety of a toothpaste containing lysozyme for the treatment of minor recurrent aphthous stomatitis (MiRAS) in a 3-month clinical trial.

    Methods: 71 participants with MiRAS were recruited to this randomized, parallel-controlled, double-blind clinical trial. Participants were allocated randomly to the test group or the control group. Read More

    Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study.
    An Bras Dermatol 2017 Sep-Oct;92(5):626-629
    Post-Graduation Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL)- Pelotas (RS), Brazil.
    Background: Recurrent aphthous stomatitis is a painful disorder of unknown etiology. It is among the most common oral mucosal lesions with high prevalence among young adults.

    Objectives: To conduct a population-based study with 18-year-old army recruiters to assess its prevalence and associated factors in male adolescents. Read More

    Exacerbation of Behçet's syndrome and familial Mediterranean fever with menstruation.
    Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):95-99. Epub 2017 Oct 24.
    Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Turkey.
    Obectives: Menstruation triggers several conditions such as migraine, recurrent aphthous stomatitis and acne vulgaris in healthy individuals. There is evidence that Behçet's syndrome (BS) and familial Mediterranean fever (FMF) may exacerbate during menstruation. The aim is to assess whether BS and FMF patients experience menstrual flares. Read More

    A Dramatic Case of Odynophagia.
    Dysphagia 2018 Feb 11;33(1):133-135. Epub 2017 Nov 11.
    Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
    We report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. The severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ENT, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). During this time, the patient received central parenteral nutrition with an episode of catheter-related septicemia, and he came to require psychiatric assistance for autolytic ideation. Read More

    Atypical Afta Major Healing after Photodynamic Therapy.
    Case Rep Dent 2017 20;2017:8517470. Epub 2017 Sep 20.
    Diabetology, San Michele Hospital, Cagliari, Italy.
    The aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity clinical examination showed several major symptomatic ulcers, previously treated with topical and systemic therapies without any benefit. Read More

    Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design.
    Adv Pharm Bull 2017 Sep 25;7(3):441-450. Epub 2017 Sep 25.
    Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
    Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Read More

    Investigation of dissolved cellulose in development of buccal discs for oromucosal drug delivery.
    Pharm Dev Technol 2017 Nov 9:1-10. Epub 2017 Nov 9.
    a Pharmaceutical Science Laboratory, Department of Biosciences, Faculty of Science and Engineering , Åbo Akademi University , Turku , FI , Finland.
    Mucoadhesive formulations have a wide scope of application for both systemic and local treatment of various diseases. In the case of recurrent aphthous stomatitis, to ensure effective therapy, the concentration of corticosteroids, and/or anesthetics at the mouth ulcer side should be maintained with minimal systemic absorption. Therefore, the aim of the study was to investigate cellulose-based formulations, in achieving suitable hardness, mucoadhesiveness, and sustained release of the active ingredients directed towards the mucosa for an extended period of time (∼4 h). Read More

    PFAPA Syndrome in a Population with Endemic Familial Mediterranean Fever.
    J Pediatr 2018 Jan 12;192:253-255. Epub 2017 Oct 12.
    Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey. Electronic address:
    We reviewed the medical records of patients with periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) to investigate the clinical course, treatment response, and association with MEFV gene mutation. Familial Mediterranean fever should be considered in patients with PFAPA who do not respond to adenotonsillectomy. Read More

    Approach to recurrent fever in childhood.
    Can Fam Physician 2017 Oct;63(10):756-762
    Professor in the Department of Paediatrics and the Department of Medicine at the University of Toronto and a staff rheumatologist in the Division of Rheumatology at The Hospital for Sick Children.
    Objective: To provide an approach to recurrent fever in childhood, explain when infections, malignancies, and immunodeficiencies can be excluded, and describe the features of periodic fever and other autoinflammatory syndromes.

    Sources Of Information: PubMed was searched for relevant articles regarding the pathogenesis, clinical findings, diagnosis, prognosis, and treatment of periodic fever and autoinflammatory syndromes.

    Main Message: Fever is a common sign of illness in children and is most frequently due to infection. Read More

    Diagnostic Criteria for Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome.
    Front Immunol 2017 24;8:1018. Epub 2017 Aug 24.
    Periodic Fevers Research Center, Institute of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica Sacro Cuore, Rome, Italy.
    Objective: To identify a set of variables that could discriminate patients with adult-onset periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome from subjects with fever of unknown origin (FUO).

    Methods: We enrolled 74 adults diagnosed with PFAPA syndrome according to the currently used pediatric diagnostic criteria and 62 additional patients with FUO. After having collected clinical and laboratory data from both groups, univariate and multivariate analyses were performed to identify the variables associated with PFAPA diagnosis. Read More

    Oral manifestations of inflammatory bowel disease.
    J Biol Regul Homeost Agents 2017 Jul-Sep;31(3):817-821
    Department of Experimental Biomedicine and Clinical Neuroscience, Section of Histology, (BIONEC), University of Palermo, Italy
    Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, have important extraintestinal manifestations, notably in the oral cavity. These oral manifestations can constitute important clinical clues in the diagnosis and management of IBD, and include changes at the immune and bacterial levels. Aphthous ulcers, pyostomatitis vegetans, cobblestoning and gingivitis are important oral findings frequently observed in IBD patients. Read More

    The absence of an association between Interleukin 1β gene polymorphisms and recurrent aphthous stomatitis (RAS).
    Arch Oral Biol 2017 Dec 19;84:45-49. Epub 2017 Sep 19.
    Department of Oral Mucosa Diseases, University of Medical Sciences, Poznań, Poland.
    Objectives: Recurrent aphthous stomatitis (RAS) is a chronic, ulcerative disease with a probable polygenic mode of inheritance and complex etiology with a strong immunological background. The aim of the present study was to determine the possible association between two single nucleotide polymorphisms (SNPs) of the IL-1β gene: IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) and RAS susceptibility in a moderately large group of patients.

    Design: One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach. Read More

    Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis.
    Prague Med Rep 2017;118(2-3):81-86
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology. IL-2 and IFN-γ are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of IL-2 and IFN-γ genes could alter the cytokine production. Read More

    Behçet disease: New aspects.
    Clin Dermatol 2017 Sep - Oct;35(5):421-434. Epub 2017 Jun 27.
    Gazi University Faculty of Medicine, Department of Dermatology Emeritus Prof, Ankara, Turkey; Dermatology and Laser Center, Reduitstrasse 13, Landau, Germany. Electronic address:
    Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. Read More

    Measles Lymphadenopathy in a Child With PFAPA Syndrome.
    Pediatr Dev Pathol 2017 Jan 1:1093526617727970. Epub 2017 Jan 1.
    2 Division of Pediatric Rheumatology, Department of Pediatrics, University of British Columbia and 37210 British Columbia Children's Hospital , Vancouver, British Columbia, Canada.
    Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a common cause of periodic fever in children. The pathogenesis of PFAPA is unknown but likely involves immune system dysregulation and may be initiated by an environmental trigger. Tonsillectomy resolves or improves symptoms in some patients, but the reason for this is unknown; moreover, specific abnormalities in tonsillectomy specimens from PFAPA patients have not been described. Read More

    Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets.
    Nat Prod Res 2017 Sep 5:1-6. Epub 2017 Sep 5.
    a College of Pharmacy and College (Institute) of Integrative Medicine , Dalian Medical University , Dalian , PR China.
    Shuanghua Baihe tablet is a traditional Chinese patent medicine which showed special advantages in the treatment of recurrent aphthous stomatitis. Scientists have improved and implemented the LC-MS/MS method, which is specific and sensitive, for comparative pharmacokinetics study of five alkaloids, including palmatine, berberine, epiberberine, jatrorrhizine and coptisine in rat plasma after oral administration of Rhizoma Coptidis extract and Shuanghua Baihe tablets. The results showed that Shuanghua Baihe tablets could promote the absorption of these five alkaloids and improved their bioavailability compared with R. Read More

    Stress as a Cause of Recurrent Aphthous Stomatitis and Its Correlation with Salivary Stress Markers.
    Chin J Physiol 2017 08;60(4):226-230
    Department of Physiology, International Medical School, MSR Nagar, MSRIT Post, Bangalore, Karanataka 560054, India.
    Stress causes an increase in cortisol and amylase. Recurrent aphthous stomatitis (RAS) results due to a multitude of causes, amongst which stress is one of the most important. Aim of the study was to estimate the level of stress, serum cortisol, salivary cortisol, amylase and electrolytes in subjects with RAS. Read More

    Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis.
    Contemp Clin Dent 2017 Apr-Jun;8(2):259-263
    Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background And Objective: Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS.

    Materials And Methods: Twenty-seven patients (13 males and 14 females, mean age of 32. Read More

    Colchicine: an ancient drug with novel applications.
    Br J Dermatol 2018 Feb 3;178(2):350-356. Epub 2018 Jan 3.
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.
    Colchicine is a treatment for gout that has been used for more than a millennium. It is the treatment of choice for familial Mediterranean fever and its associated complication, amyloidosis. The 2009 U. Read More

    Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study.
    PLoS One 2017 9;12(8):e0180939. Epub 2017 Aug 9.
    Department of Nephrology, Charité Universitätsmedizin, Berlin, Germany.
    Objectives: We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

    Methods: Following favorable results from the double-blind core phase of EXIST-2 (NCT00790400), patients were allowed to receive open-label everolimus (extension phase). Patients initially randomly assigned to everolimus continued on the same dose; those who were receiving placebo crossed over to everolimus 10 mg/day. Read More

    Evolving Frontiers in the Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Syndrome.
    Isr Med Assoc J 2017 Jul;19(7):444-447
    Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases Behçet's Disease Clinic, University of Siena, Siena, Italy.
    Background: Fevers recurring at a nearly predictable rate every 3-8 weeks are the signature symptom of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome, an acquired autoinflammatory disorder which recurs in association with at least one sign among aphthous stomatitis, pharyngitis, and/or cervical lymph node enlargement without clinical signs related to upper respiratory airways or other localized infections. The disease usually has a rather benign course, although it might relapse during adulthood after a spontaneous or treatment-induced resolution in childhood. The number of treatment choices currently available for PFAPA syndrome has grown in recent years, but data from clinical trials dedicated to this disorder are limited to small cohorts of patients or single case reports. Read More

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