3,754 results match your criteria Aphthous Stomatitis


Evaluation of salivary tumour necrosis factor-alpha in patients with recurrent aphthous stomatitis.

Eur Oral Res 2018 Sep 1;52(3):157-161. Epub 2018 Sep 1.

Department of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.

Purpose: Present study was undertaken to evaluate and compare the salivary levels of tumour necrosis factor alpha (TNF-α) in subjects with RAS, traumatic ulcers (TUs) in the oral mucosa and in healthy controls.

Materials And Methods: Present study involved 90 participants of which 30 subjects were diagnosed with RAS, 30 subjects with TUs and 30 healthy controls grouped as group 1, group 2 and group 3 respectively. Unstimulated saliva was collected from the subjects through 'Spit Technique' and the estimation of TNF-α was done by enzyme linked immunosorbent assay. Read More

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http://dx.doi.org/10.26650/eor.2018.543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365135PMC
September 2018

Clinical evaluation of dental enamel defects and oral findings in coeliac children.

Eur Oral Res 2018 Sep 1;52(3):150-156. Epub 2018 Sep 1.

Department of Basic Medical Sciences, Division of Biochemistry, Marmara University, Faculty of Dentistry, İstanbul, Turkey.

Purpose: To examine dental hard and soft tissue changes of coeliac children in order to increase the awareness of the pediatric dentists in prediagnosis of especially undiagnosed coeliac disease.

Materials And Methods: Sixty children, 28 (46.7%) boys and 32 (53. Read More

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http://eor.istanbul.edu.tr/en/yazi/10-26650-eor-2018-525-510
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http://dx.doi.org/10.26650/eor.2018.525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365134PMC
September 2018
1 Read

Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients.

Pediatr Int 2019 Jan;61(1):104-106

Second Department of Paediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.

The aim of this study was to compare the immunogenicity and side-effects of hepatitis A virus (HAV) vaccination between periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) patients and healthy controls who have not been previously exposed to HAV. A prospective observational study was carried out of 28 PFAPA patients and 76 controls who received two doses of the vaccine. Immunogenicity was expressed as seroconversion and seroprotection rates; mean HAV-immunoglobulin G concentration was measured at 0, 1, 7 and 18 months. Read More

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http://dx.doi.org/10.1111/ped.13719DOI Listing
January 2019
1 Read

Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis.

Recent Pat Drug Deliv Formul 2019 Jan 28. Epub 2019 Jan 28.

Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela, Ropar, Punjab. India.

Background: During the recent two decades the development of mucoadhesive drug delivery system has been gained tremendous importance to cure many recurrent diseases of oral cavity. The drug delivery through the buccal route is quite challenging due to limited absorption area, movements of the target region and regular flow of saliva leads to the sub-therapeutic drug level in the buccal region.

Objective: The aim is to develop unidirectional release mucoadhesive buccal film for the transmucosal delivery of Benzydamine Hydrochloride (WO2016126217Al, EP0812193B1) and evaluate the effects of different grade of HPMC polymer (US5980942A) with presumption to prolong the residence time and therapeutic effectiveness at the target site. Read More

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http://dx.doi.org/10.2174/1872211313666190128151038DOI Listing
January 2019
3 Reads

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review.

Head Neck Pathol 2019 Jan 31. Epub 2019 Jan 31.

Department of Diagnostic and Biomedical Sciences, University of Texas at Houston Health Science Center School of Dentistry, Houston, TX, USA.

Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Read More

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http://dx.doi.org/10.1007/s12105-018-0981-8DOI Listing
January 2019
1 Read

Search for Drugs Used in Hospitals to Treat Stomatitis.

Medicines (Basel) 2019 Jan 29;6(1). Epub 2019 Jan 29.

Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.

Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Read More

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http://dx.doi.org/10.3390/medicines6010019DOI Listing
January 2019
1 Read

Imerslund-Gräsbeck Syndrome in an Infant with a Novel Intronic Variant in the Gene: A Case Report.

Int J Mol Sci 2019 Jan 27;20(3). Epub 2019 Jan 27.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129 Perugia, Italy.

Imerslund-Gräsbeck syndrome (IGS) is a rare autosomal recessive disorder clinically characterized by megaloblastic anemia, benign mild proteinuria, and other nonspecific symptoms. Several pathogenetic variants in the amnionless () or cubilin () genes have been described in IGS. We describe a case of IGS with urinary tract infection and mild but persistent proteinuria at onset in an 11-month-old female child. Read More

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http://dx.doi.org/10.3390/ijms20030527DOI Listing
January 2019
1 Read

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome - PFAPA syndrome.

Authors:
Per Wekell

Presse Med 2019 Feb 22;48(1 Pt 2):e77-e87. Epub 2019 Jan 22.

Department of Pediatrics, NU-Hospital Group, 45180 Uddevalla, Sweden; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a complex autoinflammatory disease with a clinical phenotype characterised by recurrent episodes of fever, systemic inflammation and symptoms and signs depicted in disease acronym. Although PFAPA is the most common autoinflammatory disease among children in many parts of the world, the condition is still an enigma, which include the regular episodes, the prompt responses to corticosteroids, the genetic bases for the familial clustering and therapeutic effects of tonsillectomy. This review explores PFAPA syndrome with the aim of describing the current clinical and scientific understanding of the condition. Read More

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http://dx.doi.org/10.1016/j.lpm.2018.08.016DOI Listing
February 2019

Comparing Serum and Salivary Levels of Vitamin D in Patients with Recurrent Aphthous Stomatitis and Healthy Individuals.

J Dent (Shiraz) 2018 Dec;19(4):295-300

Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Statement Of The Problem: Recurrent aphthous stomatitis (RAS) is the most prevalent ulcerative condition of the oral mucosa. Many studies have emphasized on immunologic factors as the reason of inducing RAS; however, the exact etiologic cause of RAS has not been identified yet. Vitamin D has an endocrine function and regulatory effects on the immune system. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338692PMC
December 2018
5 Reads

Serum levels of total antioxidant status, nitric oxide and nitric oxide synthase in minor recurrent aphthous stomatitis patients.

Medicine (Baltimore) 2019 Jan;98(3):e14039

Department of Stomatology, the 980th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Shijiazhuang.

Background: Recurrent aphthous stomatitis (RAS) is one of the most common inflammatory ulcerative conditions of oral cavity with uncertain etiology. Several studies have reported that oxidative stress may be associated with RAS. The aim of this study was to compare the serum levels of total antioxidant status (TAS), nitric oxide (NO) and nitric oxide synthase (NOS) in minor RAS (MiRAS) patients with healthy individuals and determine the possible association of MiRAS with the 3 physiological parameters mentioned above. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0002
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http://dx.doi.org/10.1097/MD.0000000000014039DOI Listing
January 2019
8 Reads

Psychometric analysis of stress, anxiety and depression in patients with recurrent aphthous Stomatitis-A cross-sectional survey based study.

J Clin Exp Dent 2018 Nov 1;10(11):e1109-e1114. Epub 2018 Nov 1.

Assistant Professor, Department of Oral Medicine and Radiology.

Background: Recurrent Aphthous Stomatitis is a chronic inflammatory immune mediated condition associated with single or multiple, painful recurring ulcers of the oral mucosa. Psychological stress is a common trigger factor identified for the onset and progression of this condition. The study aimed to evaluate stress, anxiety and depression using the Hospital Anxiety and Depression scale and stress by the General Health Questionnaire in subjects with Recurrent Aphthous Stomatitis (RAS). Read More

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http://dx.doi.org/10.4317/jced.55012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311397PMC
November 2018

Use of Apremilast for Aphthous Ulcers in a Patient With Behçet’s Syndrome

J Drugs Dermatol 2018 Dec;17(12):1328-1329

Behçet’s syndrome is an inflammatory disease characterized by aphthous oral ulcers and several systemic manifestations, which include genital ulcers, ocular disease, skin lesions, arthritis, and vascular disease Read More

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December 2018
5 Reads

High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome.

J Med Biochem 2018 Dec 1;37(4):507-509. Epub 2018 Dec 1.

Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, Wrocław, Poland.

PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). Read More

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http://dx.doi.org/10.1515/jomb-2017-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298472PMC
December 2018
1 Read

Low laser therapy as an effective treatment of recurrent aphtous ulcers: a clinical case reporting two locations.

Pan Afr Med J 2018 10;30:205. Epub 2018 Jul 10.

Department of Oral Surgery, Faculty of Dentistry, Mohamed V University, Rabat, Morocco.

Apthous ulcers, commonly referred to as canker sores, are the most common ulcerative lesions of the oral mucosa. These are usually painful and are associated with redness and occasional bleeding from the affected area(s). Low Level Laser Therapy (LLLT) has shown excellent results in relieving the pain and complete remission of the oral ulcers. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.205.15779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294968PMC
January 2019
6 Reads

Chinese herbal medicine for recurrent aphthous stomatitis: a protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(50):e13681

Graduate School, Zhejiang Chinese Medical University, Hangzhou.

Background: Recurrent aphthous stomatitis (RAS) is the most frequent form of oral ulceration, characterized by recurrent oral mucosal ulceration in an otherwise healthy individual. This study was designed to evaluate the efficacy and safety of Chinese herbal medicine for recurrent aphthous stomatitis.

Methods: Five databases will be searched from inception to date, including PubMed, Cochrane Library, EMBASE,CNKI, and CBM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320145PMC
December 2018

Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis.

Medicines (Basel) 2018 Dec 10;5(4). Epub 2018 Dec 10.

Department of physiology, School of medicine, Showa University, Tokyo 142-8555, Japan.

Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Read More

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http://www.mdpi.com/2305-6320/5/4/130
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http://dx.doi.org/10.3390/medicines5040130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313652PMC
December 2018
9 Reads

Severe HIV-associated aphthous stomatitis treated with etanercept.

Med Mal Infect 2018 Dec 6. Epub 2018 Dec 6.

Inserm U1175, maladies infectieuses, CHU de Montpellier, 34295 Montpellier cedex 5, France. Electronic address:

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http://dx.doi.org/10.1016/j.medmal.2018.11.005DOI Listing
December 2018

Establishment of Role of IL-2, IL-10 and IL-12 in Patients with Recurrent Aphthous Stomatitis-A Clinical Study.

J Contemp Dent Pract 2018 Oct 1;19(10):1242-1245. Epub 2018 Oct 1.

Department of Periodontics, DY Patil Dental School, Lohegaon, Pune, Maharashtra, India.

Background: Recurrent aphthous stomatitis is a vesiculobul-lous disease characterized by painful ulcers in the oral cavity. The role of interleukins such as IL-2, IL-10 and IL-12 in initiating disease demands careful assessment. The present study was conducted to determine the level of IL-2, IL-10 and IL-12 in patients with recurrent aphthous stomatitis. Read More

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October 2018

Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review.

Clin Rheumatol 2019 Jan 28;38(1):11-17. Epub 2018 Nov 28.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most frequent non-hereditary autoinflammatory disorder in childhood: Its onset is usually observed before 5 years, though reports regarding adulthood are increasing. The pathogenesis of the syndrome is not completely understood, but a multifactorial origin, probably based on a polygenic pattern of susceptibility, is the most probable rational pathogenetic hypothesis. Treatment of PFAPA syndrome relies on the administration of low-dose corticosteroids, which promptly abort flares but cannot prevent subsequent disease episodes over time. Read More

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http://link.springer.com/10.1007/s10067-018-4361-2
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http://dx.doi.org/10.1007/s10067-018-4361-2DOI Listing
January 2019
14 Reads

Soft Tissue Disorders of the Mouth.

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

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http://dx.doi.org/10.1016/j.emc.2018.09.006DOI Listing
February 2019
14 Reads

Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis.

Immunobiology 2018 Nov 2. Epub 2018 Nov 2.

Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade 11000, Serbia.

The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183017
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http://dx.doi.org/10.1016/j.imbio.2018.10.006DOI Listing
November 2018
12 Reads

Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management.

J Formos Med Assoc 2018 Nov 14. Epub 2018 Nov 14.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae. Clinically, three types of RAS, namely minor, major, and herpetiform types, can be identified. RAS more commonly affects labial mucosa, buccal mucosa, and tongue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183074
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http://dx.doi.org/10.1016/j.jfma.2018.10.023DOI Listing
November 2018
8 Reads

The Broad-Ranging Panorama of Systemic Autoinflammatory Disorders with Specific Focus on Acute Painful Symptoms and Hematologic Manifestations in Children.

Authors:
Donato Rigante

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018067. Epub 2018 Nov 1.

Institute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal membranes, gastrointestinal tube, and other tissues, which recur with variable rhythmicity and display reactive amyloidosis as a potential long-term complication. Dysregulated inflammasome activity leading to overproduction of many proinflammatory cytokines, such as interleukin-1 (IL-1), and delayed shutdown of inflammation are considered crucial pathogenic keys in the vast majority of SAIDs. Progress of cellular biology has partially clarified the mechanisms behind monogenic SAIDs, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome, mevalonate kinase deficiency, hereditary pyogenic diseases, idiopathic granulomatous diseases and defects of the ubiquitin-proteasome pathway. Read More

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http://dx.doi.org/10.4084/MJHID.2018.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223578PMC
November 2018
1 Read

Vitamin D levels in patients with recurrent aphthous stomatitis.

BMC Oral Health 2018 Nov 9;18(1):186. Epub 2018 Nov 9.

Department of Family Medicine, Hitit University Medical School, Çorum, Turkey.

Background: Lower serum vitamin D levels, a major public health problem worldwide, has been found to be associated with various infectious diseases, cancers, autoimmune and dermatological diseases. The serum levels of vitamin D in patients with recurrent aphthous stomatitis are not clear. We investigated the vitamin D levels in patients with recurrent aphthous stomatitis. Read More

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https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12903-018-0653-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230238PMC
November 2018
6 Reads

Incidence of indications for tonsillectomy and frequency of evidence-based surgery: a 12-year retrospective cohort study of primary care electronic records.

Br J Gen Pract 2019 Jan 5;69(678):e33-e41. Epub 2018 Nov 5.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: Neither the incidence of indications for childhood tonsillectomy nor the proportion of tonsillectomies that are evidence-based is known.

Aim: To determine the incidence of indications for tonsillectomy in UK children, and the proportion of tonsillectomies meeting evidence-based criteria.

Design And Setting: A retrospective cohort study of electronic medical records of children aged 0-15 years registered with 739 UK general practices contributing to a research database. Read More

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http://dx.doi.org/10.3399/bjgp18X699833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301361PMC
January 2019
2 Reads

New Functions of Classical Compounds against Orofacial Inflammatory Lesions.

Medicines (Basel) 2018 Nov 1;5(4). Epub 2018 Nov 1.

Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of this is a disease known as stomatitis; although stomatitis itself is not a life-threatening disease, it severely impairs the individual's quality of life, and thus a standard therapeutic strategy for it has already been established. The topical application of a bioactive agent is quite easy, and a strong anti-inflammatory agent can be used without significant adverse effects. Read More

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http://dx.doi.org/10.3390/medicines5040118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313344PMC
November 2018
8 Reads

[Aphthous mouth ulcers as an initial manifestation of sécukinumab-induced inflammatory bowel disease].

Ann Dermatol Venereol 2018 Nov 23;145(11):676-682. Epub 2018 Oct 23.

Université François-Rabelais, 37000 Tours, France; Service de dermatologie, CHU, hôpital Trousseau, 37044 Tours cedex, France; Équipe BIP, ISP 1282 INRA-Université de Tours, 37000 Tours, France. Electronic address:

Background: Secukinumab, a humanized monoclonal antibody targeting interleukin 17A, has been associated with the development of inflammatory bowel diseases. We report a case of a female patient developing recurrent oral ulcers prior to inflammatory bowel disease induced by secukinumab. The patient had developed similar oral ulcers 6 years earlier while on tocilizumab (targeting IL6R), suggesting an immunological link between the two episodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183049
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http://dx.doi.org/10.1016/j.annder.2018.07.009DOI Listing
November 2018
8 Reads

Familial Mediterranean Fever Is Commonly Diagnosed in Children in Israel with Periodic Fever Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome.

J Pediatr 2019 Jan 22;204:270-274. Epub 2018 Oct 22.

Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel; Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Objectives: To describe a cohort of pediatric patients diagnosed with periodic fever aphthous stomatitis, pharyngitis and adenitis (PFAPA) and familial Mediterranean fever (FMF) and compare them with children diagnosed solely with PFAPA (sPFAPA).

Study Design: Clinical, laboratory, and genetic data of all pediatric patients diagnosed with sPFAPA or PFAPA/FMF were retrospectively collected from 2 primary Israeli medical referral centers and compared.

Results: Of 270 patients with PFAPA, more than one-half were of Mediterranean ancestry. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.08.080DOI Listing
January 2019
6 Reads

Comorbidity profiles among patients with recurrent aphthous stomatitis: A case-control study.

J Formos Med Assoc 2018 Oct 19. Epub 2018 Oct 19.

Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Radiation Oncology, Wanfang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background/purpose: Recurrent aphthous stomatitis (RAS) is common and associated with certain comorbidities. The aim of this study was to investigate the prevalence of selected comorbidities in patients with RAUs and to compare the risks of comorbidity between the two cohorts of patients with or without RAUs based on the Taiwanese National Health Insurance Research Database.

Methods: This case-control study included patients with recurrent aphthous stomatitis (the RAS cohort) and patients without recurrent aphthous stomatitis using 1:1 matching for year of index date, age, sex, monthly income, geographical location, and urbanization level (the non-RAS cohort). Read More

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http://dx.doi.org/10.1016/j.jfma.2018.10.002DOI Listing
October 2018
2 Reads

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study.

Eur J Oral Sci 2018 12 20;126(6):485-492. Epub 2018 Oct 20.

Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor α, IL4Rα), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case-control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Read More

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http://dx.doi.org/10.1111/eos.12577DOI Listing
December 2018
1 Read

Association Between Anxiety, Depression, and Salivary Cortisol Levels in Patients with Recurrent Aphthous Stomatitis.

Turk Arch Otorhinolaryngol 2018 Sep 1;56(3):166-169. Epub 2018 Sep 1.

Department of Otorhinolaryngology, Elazığ Training and Research Hospital, Elazığ, Turkey.

Objective: Recurrent aphthous stomatitis (RAS) is the most common ulcerative disease of the oral mucosa that commonly affects the general population. The objective of this study was to conduct a research in assesing the relationship between psychological disorders including anxiety, depression and salivary cortisol levels in patients with RAS.

Methods: Thirty-nine patients suffering from minor RAS were enrolled in the study after obtaining an informed consent. Read More

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http://www.turkarchotolaryngol.net/eng/makale/737/78/Full-Te
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http://dx.doi.org/10.5152/tao.2018.3242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177496PMC
September 2018
5 Reads

The Antimicrobial Peptide Nal-P-113 Exerts a Reparative Effect by Promoting Cell Proliferation, Migration, and Cell Cycle Progression.

Biomed Res Int 2018 12;2018:7349351. Epub 2018 Sep 12.

Department of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, China.

Objective: The primary purpose of this study was to evaluate the reparative efficacy of a novel antimicrobial peptide, Nal-P-113, in shortening the healing time of oral mucosal ulcers by promoting cell proliferation and migration and accelerating the cell cycle.

Methods: Cell counting kit-8 (CCK-8) and wound-healing assays were used to evaluate the proliferation and migration of human immortalized oral epithelial cells (HIOECs). The cell cycle distribution of HIOECs was analyzed by flow cytometry. Read More

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https://www.hindawi.com/journals/bmri/2018/7349351/
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http://dx.doi.org/10.1155/2018/7349351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157167PMC
January 2019
2 Reads

Aphthous Stomatitis and Laryngitis, Another Form of Presentation of an IgG4-Related Disease?

Reumatol Clin 2018 Oct 5. Epub 2018 Oct 5.

Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas (UEAS), Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

IgG4-related disease is characterized by a lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis. It can present as parotid gland enlargement, tubulointerstitial nephritis, retroperitoneal fibrosis or pancreatitis, although nearly any organ can be affected. We report the case of a 37-year-old woman who presented with severe dysphonia and recurrent painful aphthous ulcers, with histopathological findings at the level of the larynx that revealed a lymphoplasmacytic infiltrate and IgG4 positivity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1699258X183019
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http://dx.doi.org/10.1016/j.reuma.2018.08.011DOI Listing
October 2018
8 Reads

Aphthous Stomatitis Major in a 4-Month-Old Infant.

J Emerg Med 2018 Dec 5;55(6):e157-e158. Epub 2018 Oct 5.

Department of Dentistry, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jemermed.2018.09.018DOI Listing
December 2018
4 Reads

Case 2: Headaches with Recurrent Rash and Mucosal Ulcerations.

Pediatr Rev 2018 Oct;39(10):519-522

Department of Pediatrics, CMC Myers Park Pediatrics/CHS-Levine Children's, Charlotte, NC.

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http://dx.doi.org/10.1542/pir.2017-0231DOI Listing
October 2018
3 Reads

Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison.

J Photochem Photobiol B 2018 Dec 20;189:1-4. Epub 2018 Sep 20.

2(nd) Hospital, International Department of Stomatology, Shijiazhuang, Hebei Province, China; University of Côte d'Azur, Micoralis Research Laboratory EA 7354, 24 Avenue des Diables bleus, 06357 Nice, Cedex 4, France; Micoralis Laboratory EA7354, Faculty of Dentistry, University of Côte d'Azur, 24 Avenue des Diables bleus, 06357 Nice, Cedex 4, France. Electronic address:

Recurrent Aphthous Stomatitis (RAS) is an oral condition characterized by painful ulcerations of the mucosa, healing spontaneously in 10-14 days but sometimes, due to their number, size and frequency of recurrence, lesions may be the cause of a severe disconfort with an impact on the quality of life of the patients due to the increased difficulty to eat, swallow and speak. For RAS, different protocols and treatments have been proposed as standard topical treatment to provide symptomatic relief, immunomodulating drugs as thalidomide, colchicine and steroids have been also proposed with the outcome to relief the pain, accelerating the healing process and increase the duration of ulcer-free period but without definitive results and without side effects. In this study we analysed the effect of laser treatment of aphthous lesions with four devices available on the market, two with wavelength in the infra-red region (2940 nm 808 nm) and two with a wavelength in the visible region (450 nm and 635 nm). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10111344183086
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http://dx.doi.org/10.1016/j.jphotobiol.2018.09.016DOI Listing
December 2018
5 Reads

Towards a new set of classification criteria for PFAPA syndrome.

Pediatr Rheumatol Online J 2018 Sep 21;16(1):60. Epub 2018 Sep 21.

Unité Romande d'Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, Lausanne and HUG, Geneva, Switzerland.

Background: Diagnosis of Periodic Fever, Aphthous stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) syndrome is currently based on the modified Marshall's criteria, but no validated evidence based classification criteria for PFAPA has been established so far.

Methods: A multistep process, based on the Delphi and Nominal Group Technique was conducted. After 2 rounds of e-mail Delphi survey involving 21 experts in autoinflammation we obtained a list of variables that were discussed in an International Consensus Conference. Read More

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http://dx.doi.org/10.1186/s12969-018-0277-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151014PMC
September 2018
2 Reads

Epidemiology of oral mucosal lesions in Slovenia.

Radiol Oncol 2018 Sep 11;52(3):263-266. Epub 2018 Sep 11.

Private Dental Practice, Ljubljana, Slovenia.

Background Among the diseases of oral mucosa, malignant tumors are the most dangerous, but not the most common lesions that might appear in the oral cavity. Since most of the studies are focused on the detection of cancer in the oral cavity, we were interested in detecting the frequency of benign changes of the oral mucosa in Slovene population. Oral mucosal lesions are important pointer of oral health and quality of life, especially in elderly. Read More

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http://dx.doi.org/10.2478/raon-2018-0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137360PMC
September 2018
1 Read

Painful Oral Lesions.

Dent Clin North Am 2018 10 14;62(4):597-609. Epub 2018 Aug 14.

Naval Postgraduate Dental School, Bethesda, MD, USA. Electronic address:

Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. Read More

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http://dx.doi.org/10.1016/j.cden.2018.06.002DOI Listing
October 2018
11 Reads

Evaluation of the effect of pre-operative oral midazolam on post-operative oral fluid intake after tonsillectomy.

Int J Pediatr Otorhinolaryngol 2018 Oct 10;113:248-251. Epub 2018 Aug 10.

Department of Otolaryngology, Nationwide Children's Hospital, USA. Electronic address:

Introduction: The objective of this study was to determine if pre-operative oral midazolam administration decreased postoperative oral fluid intake after tonsillectomy with or without adenoidectomy.

Methods: A retrospective chart review identified 104 patients who were undergoing tonsillectomy with and without adenoidectomy who were not given midazolam preoperatively and 182 who were given midazolam preoperatively. Indications for tonsillectomy with or without adenoidectomy included obstructive sleep apnea, recurrent acute streptococcal pharyngotonsillitis, and, in selected cases, periodic fever with aphthous stomatitis, pharyngitis and adenopathy. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.08.011DOI Listing
October 2018
1 Read

The influence of oral health and psycho-social well-being on clinical outcomes in Behçet's disease.

Rheumatol Int 2018 Oct 27;38(10):1873-1883. Epub 2018 Aug 27.

Centre for Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, 4 Newark Street, London, E1 2AT, UK.

This study was designed to investigate the association of oral ulceration and oral health factors, together with psycho-social well-being in Behçet's disease (BD), and to clarify the importance of psycho-social support of patients in the overall management of BD. The study comprised of a cohort of 146 BD patients (mean age ± SD = 39.65 ± 13. Read More

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http://dx.doi.org/10.1007/s00296-018-4117-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132727PMC
October 2018
3 Reads

[Clinical analysis for oral mucosal disease in 21 972 cases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Jul;43(7):779-783

Department of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment.
 Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.07.013DOI Listing
July 2018
1 Read

Adamantiades-Behçet Disease at the Beginning of the Silk Route: North-East Italian Experience.

Acta Dermatovenerol Croat 2017 Dec;25(4):295-297

Nicola di Meo, MD, Dermatology Department, University of Trieste, Ospedale Maggiore di Trieste, Piazza Ospedale 1, IV Piano Palazzina Infettivi, 34100 Trieste, Italy;

Dear Editor, Adamantiades-Behçet's disease (ABD) is an inflammatory disease classified as vasculitis, which was originally diagnosed in patients with aphthous stomatitis, genital ulcerations, and ocular manifestations. However, any organ or system may be involved, particularly the central and peripheral nervous systems, joints, as well as the gastrointestinal tract. The etiology of ABD is still not fully understood, but some evidence indicates that an autoimmune process could be triggered by an infectious or environmental agent specific for the geographic region (1). Read More

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December 2017
6 Reads

Comment on "Mean Platelet Volume: A Reliable Marker of Inflammation in Recurrent Aphthous Stomatitis and Behçet's Disease?"

Authors:
Esin Avsar

Indian Dermatol Online J 2018 Jul-Aug;9(4):281

Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey.

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http://dx.doi.org/10.4103/idoj.IDOJ_59_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042179PMC
July 2018
9 Reads

Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial.

Electron Physician 2018 Jun 25;10(6):6912-6919. Epub 2018 Jun 25.

DDS of Oral and Maxillofacial Medicine, Professor, Faculty of Dentistry, Oral Health Research Center, Babol University of Medical Sciences, Babol, Iran.

Background: Recurrent aphthous stomatitis (RAS) is one of the most common painful oral lesions of which there is no certain treatment.

Objective: The aim of this study was to determine the effect of Chitosan mouthwash 0.5% on RAS. Read More

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http://dx.doi.org/10.19082/6912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049970PMC

Familial Mediterranean fever and periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: shared features and main differences.

Rheumatol Int 2019 Jan 17;39(1):29-36. Epub 2018 Jul 17.

Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.

Autoinflammatory diseases are characterized by fever attacks of varying durations, associated with variety of symptoms including abdominal pain, lymphadenopathy, polyserositis, arthritis, etc. Despite the diversity of the clinical presentation, there are some common features that make the differential diagnosis of the autoinflammatory diseases challenging. Familial Mediterranean fever (FMF) is the most commonly seen autoinflammatory conditions, followed by syndrome associated with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA). Read More

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http://dx.doi.org/10.1007/s00296-018-4105-2DOI Listing
January 2019
2 Reads

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study.

Cancer Med 2018 Aug 15;7(8):4104-4114. Epub 2018 Jul 15.

Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population-based database in Taiwan.

Materials And Methods: We selected study participants from the National Health Insurance Research Database from January 2000 to December 2008. Read More

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http://dx.doi.org/10.1002/cam4.1685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089185PMC
August 2018
2 Reads

[Clinical and genetic analysis of 11 cases with periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome].

Zhonghua Er Ke Za Zhi 2018 Jul;56(7):524-528

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the clinical, inflammatory and genetic characteristics of cases with periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. Clinical and inflammatory manifestations and gene sequencing of 11 cases with PFAPA were retrospectively analyzed. Inflammatory markers including white blood cell (WBC) , C reactive protein (CRP) , and serum amyloid A (SAA) were compared between febrile period and intermittent period. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.07.010DOI Listing
July 2018
3 Reads

Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients.

PLoS One 2018 10;13(7):e0200363. Epub 2018 Jul 10.

School of Medicine, Inha University, Incheon, Republic of Korea.

Background: The prevalence of inflammatory bowel disease (IBD) in South Korea is increasing. Although extraintestinal manifestations (EIMs) are an important factor in the clinical outcomes of IBD patients, EIMs have not yet been investigated in Korea. Thus, we conducted a cross-sectional study to assess the prevalence of EIMs in Korean IBD patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039042PMC
January 2019
11 Reads