3,924 results match your criteria Aphthous Stomatitis


Diagnostic Sensitivity of Different Applications of Pathergy Test for Behçet's Disease.

Arch Rheumatol 2020 Mar 15;35(1):29-34. Epub 2019 Apr 15.

Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey.

Objectives: This study aims to compare the sensitivity of the intradermal application of the pathergy test with the "three-step pathergy test".

Patients And Methods: The study included 60 patients with Behçet's disease (BD) (23 males, 37 females; mean age 33.9±9. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322300PMC

Thalidomide use in the management of oromucosal disease: A 10-year review of safety and efficacy in 12 patients.

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jun 17. Epub 2020 Jun 17.

Consultant, Oral Medicine, Royal National ENT and Eastman Dental Hospitals, London, UK.

Objective: Thalidomide is an effective systemic agent in the management of ulcerative oromucosal conditions. However, its clinical use is limited because of its known adverse effect profile, including teratogenicity, peripheral neuropathy, and thromboembolic risk. The aim of this study was to review the efficacy and safety of thalidomide over a 10-year period in an Oral Medicine specialty clinic. Read More

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http://dx.doi.org/10.1016/j.oooo.2020.06.009DOI Listing

Helicobacter pylori and gastric hyperacidity, and their association with recurrent aphthous stomatitis.

Authors:
S H Al-Amad

Int J Oral Maxillofac Surg 2020 Jun 30. Epub 2020 Jun 30.

Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, UAE. Electronic address:

Helicobacter pylori is an established cause of gastric ulcers. Its role in causing recurrent aphthous stomatitis (RAS) remains controversial. Fifty-two RAS patients and 52 sex-matched controls were recruited in this case-control study. Read More

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http://dx.doi.org/10.1016/j.ijom.2020.05.013DOI Listing

Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.

Am J Clin Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Haematology Department, Institut Universitaire du Cancer Toulouse Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France.

The development of Bruton's tyrosine kinase (BTK) inhibitors represents a major breakthrough in the treatment of chronic lymphocytic leukemia and other B cell malignancies. The first-generation inhibitor ibrutinib works by covalent irreversible binding to BTK, a non-receptor tyrosine kinase of the TEC (transient erythroblastopenia of childhood) family that plays a critical role in the B-cell receptor signaling pathway. It also induces an 'off-target' inhibition of a range of other kinases including (but not limited to) epidermal growth factor receptor (EGFR), SRC, and other kinases of the TEC family (interleukin-2-inducible T-cell kinase [ITK], Tec, BMX). Read More

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http://dx.doi.org/10.1007/s40257-020-00535-xDOI Listing

Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis.

Braz J Med Biol Res 2020 26;53(8):e9886. Epub 2020 Jun 26.

Department of Stomatology, Jiangmen Maternal and Child Health Hospital (Jiangmen Children's Hospital), Jiangmen, Guangdong, China.

The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Read More

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http://dx.doi.org/10.1590/1414-431X20209886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326376PMC

Neutrophil Elastase and Endogenous Inhibitors in Behçet's Disease Saliva.

Clin Exp Immunol 2020 Jun 24. Epub 2020 Jun 24.

Queen Mary University of London, Centre for Oral Immunobiology and Regenerative Medicine, Barts and The London School of Medicine and Dentistry, Blizard Building, 4 Newark Street, Whitechapel London, E1 2AT, UK.

Behçet's disease (BD) is a vasculitis of unknown aetiology typified by chronic recurrent oral ulcers and systemic inflammatory manifestations. Neutrophils, and specifically their protease neutrophil elastase (NE), have been implicated in its pathology. Although NE is an effective antimicrobial, excessive NE can damage host tissue. Read More

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http://dx.doi.org/10.1111/cei.13483DOI Listing

Oral Manifestations of Inflammatory Bowel Disease and the Role of Non-Invasive Surrogate Markers of Disease Activity.

Medicines (Basel) 2020 Jun 16;7(6). Epub 2020 Jun 16.

Unit of Gastroenterology, Molinette Hospital, 10126 Turin, Italy.

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), can be associated with several extra-intestinal manifestations requiring a multidisciplinary management both in terms of work-up and therapy. Oral lesions are common in patients with IBD, with a prevalence ranging from 5% to 50%. These can represent an oral location of IBD as well as a side-effect of drugs used to treat the intestinal disease. Read More

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http://dx.doi.org/10.3390/medicines7060033DOI Listing

A family-based genome-wide association study of recurrent aphthous stomatitis.

Oral Dis 2020 Jun 18. Epub 2020 Jun 18.

Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

Objectives: The aetiology of recurrent aphthous stomatitis (RAS) remains unknown. Individuals may share features of genetic susceptibility and there may also be a hereditary component. The aim was to identify patterns of association and segregation for genetic variants and to identify the genes and signalling pathways that determine the risk of developing RAS, through a family-based genome-wide association study (GWAS). Read More

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http://dx.doi.org/10.1111/odi.13490DOI Listing

Recurrent, Severe Aphthous Stomatitis and Mucosal Ulcers as Primary Manifestations of a Novel Gain-of-Function Mutation.

Front Immunol 2020 28;11:967. Epub 2020 May 28.

Department of Infectious and Pediatric Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Chronic mucocutaneous candidiasis (CMC) characterized by persistent and recurrent Candida infection of the skin, nails, and the mucosa membranes has been proposed as the major infectious phenotype in patients with gain-of-function mutation of signal transducer and activator of transcription 1 (STAT1) 1. However, viral infections caused mostly by herpesviruses, and a broad range of autoimmune disorders may also be part of the clinical phenotype. We report here on a 31 years old female patient suffering from severe mucosal aphthous mucositis and ulcers and recurrent herpes simplex for decades. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270203PMC

The association between serum zinc levels and subjective symptoms in zinc deficiency patients with chronic liver disease.

J Clin Biochem Nutr 2020 May 6;66(3):253-261. Epub 2020 Mar 6.

Department of Hepatology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku, Sapporo 060-0033, Japan.

This study aimed to analyze the association between serum zinc levels and major subjective symptoms in zinc deficiency patients with chronic liver disease. 578 patients with chronic liver disease were enrolled. The patients, whose serum zinc level of <80 µg/dl, completed a questionnaire to determine whether they had subjective symptoms of the five conditions (taste disorder, aphthous stomatitis, dermatitis, alopecia, and anorexia). Read More

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http://dx.doi.org/10.3164/jcbn.19-99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263930PMC

Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis.

Proc Natl Acad Sci U S A 2020 Jun 9;117(25):14405-14411. Epub 2020 Jun 9.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. The disease appears to cluster in families, but the pathogenesis is unknown. We queried two European-American cohorts and one Turkish cohort (total = 231) of individuals with PFAPA for common variants previously associated with two other oropharyngeal ulcerative disorders, Behçet's disease and recurrent aphthous stomatitis. Read More

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http://dx.doi.org/10.1073/pnas.2002051117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322016PMC

Increased Prevalence of Q703K Variant Among Patients With Autoinflammatory Diseases: An International Multicentric Study.

Front Immunol 2020 14;11:877. Epub 2020 May 14.

Pediatric Rheumatology Unit of Western Switzerland, Pediatric Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

The inflammasome has been recognized as one of the key components of innate immunity. Gain-of-function mutations in the exon 3 of gene have been implicated in inflammatory diseases suggesting the presence of functionally important sites in this region. Q703K (c. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241420PMC

Recurrent Aphthous Stomatitis.

Actas Dermosifiliogr 2020 May 22. Epub 2020 May 22.

Departamento de Dermatología, Hospital Royo Villanova, Zaragoza, España. Electronic address:

Recurrent aphthous stomatitis is a chronic inflammatory disease of the oral mucosa. It is characterized by painful mouth ulcers that cannot be explained by an underlying disease. Recurrent oral mucosal ulcers require a proper differential diagnosis to rule out other possible causes before recurrent aphthous stomatitis is diagnosed. Read More

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http://dx.doi.org/10.1016/j.ad.2019.09.004DOI Listing

The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial.

Complement Ther Med 2020 May 15;50:102401. Epub 2020 Apr 15.

Pharmacology Department, Medical School, Birjand University of Medical Sciences, Birjand, 9717853577, Iran. Electronic address:

Objectives: The aim of this study was to compare the efficacy of the diphenhydramine solution (DS) and diphenhydramine-containing glycyrrhiza glabra (DSG) in the treatment of recurrent aphthous stomatitis (RAS).

Design: It was a double-blind randomized clinical trial that was conducted from July to September 2018 at the Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.

Intervention: DSG was made by adding 5% hydroethanolic extract of licorice to the diphenhydramine elixir. Read More

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http://dx.doi.org/10.1016/j.ctim.2020.102401DOI Listing

Oral bacterial diversity is inversely correlated with mucosal inflammation.

Oral Dis 2020 May 17. Epub 2020 May 17.

Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Objective: We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP).

Methods: Patients with RAS (n = 15) and LP (n = 18) and healthy controls (n = 13) were recruited using criteria to reduce the effect of factors that influence the microbiota structure independently of oral mucosal disease. Clinical severity was quantified using validated scoring methods. Read More

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http://dx.doi.org/10.1111/odi.13420DOI Listing

Post-surgical skin ulcers due to cytomegalovirus vasculopathy in a renal transplant recipient.

JAAD Case Rep 2020 May 11. Epub 2020 May 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211735PMC

Photobiomodulation therapy for the management of recurrent aphthous stomatitis in children: clinical effectiveness and parental satisfaction.

Med Oral Patol Oral Cir Bucal 2020 Jul 1;25(4):e549-e553. Epub 2020 Jul 1.

Dental Clinic, p.le Spedali Civili n.1 25133 Brescia

Background: This study aims to evaluate the effectiveness of the photobiomodulation therapy (PBMT) in the treatment of minor recurrent aphthous stomatitis (MiRAS) in children, in terms of pain relief, lesion size reduction and the parental satisfaction of the therapy.

Material And Methods: This randomized controlled study was carried out on 60 children with clinical diagnosis of MiRAS. Patients were randomized into two groups: group A receiving laser therapy and group B receiving sham therapy (placebo). Read More

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http://dx.doi.org/10.4317/medoral.23573DOI Listing

Comparison of microbiomes in ulcerative and normal mucosa of recurrent aphthous stomatitis (RAS)-affected patients.

BMC Oral Health 2020 Apr 29;20(1):128. Epub 2020 Apr 29.

State Key Laboratory of Microbial Technology, Qilu Hospital, Shandong University, Qingdao, Shandong, China.

Background: Recurrent aphthous stomatitis (RAS) is the most common form of oral ulcerative disease, whose cause is still unknown. Researchers have found the association of many factors with the occurrence of RAS, and proposed oral bacterial infection could be a cause for this disease.

Methods: To investigate whether the occurrence of RAS is associated with oral bacterial infection, we performed high throughput sequencing analysis of bacterial samples collected from the normal oral mucosa and aphthous ulcers of 24 patients. Read More

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http://dx.doi.org/10.1186/s12903-020-01115-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189554PMC

Why and How Should We Treat Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome?

Authors:
Michaël Hofer

Paediatr Drugs 2020 Jun;22(3):243-250

Unité Romande d'immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, Lausanne, and HUG, Geneva, Switzerland.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is characterized by recurrent fever flares accompanied by symptoms and signs forming the disease acronym and alternating with asymptomatic periods. Despite the disease having a generally favorable outcome, with spontaneous remission after a few years, it does have a major impact on the quality of life of the child and his or her relatives. Beside symptomatic medications during fever flares, the most used treatment consists of a single dose of corticosteroids at flare onset to interrupt the attack; fever resolves usually within a few hours, but often with a shorter interval between the attacks. Read More

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http://dx.doi.org/10.1007/s40272-020-00393-4DOI Listing

Autoinflammatory Diseases in Childhood

Balkan Med J 2020 04 27. Epub 2020 Apr 27.

Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa Cerrahpaşa School of Medicine, İstanbul, Turkey

Autoinflammatory diseases are characterized by recurrent fevers and clinical findings of impaired natural immunity and can involve various organ systems. The concept of autoinflammatory disease emerged after the definition of familial Mediterranean fever and tumor necrosis factor receptor-associated periodic syndrome. This new disease group was considered to differ from the standard concept of autoimmune diseases, which is relatively better known in terms of basic features, such as defects in innate immunity and the absence of antibodies. Read More

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http://dx.doi.org/10.4274/balkanmedj.galenos.2020.2020.4.82DOI Listing

Cryptococcal pneumonia in an adolescent with a gain-of-function variant in signal transduction and activator of transcription 1 ().

BMJ Case Rep 2020 Apr 22;13(4). Epub 2020 Apr 22.

Department of Pediatric and Adolescent Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA

An adolescent male with a history of autoimmune enteropathy, autoimmune hypothyroidism, aphthous stomatitis and recurrent oral infections only in the setting of curative antibiotic courses presented with cryptococcal pneumonia and perihilar adenitis, which was successfully treated with antifungal therapy. The patient had a complex history with several immunological anomalies. Whole exome sequencing revealed a known pathogenic variant, associated with gain of function (GOF). Read More

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http://dx.doi.org/10.1136/bcr-2019-234120DOI Listing

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group.

Pediatr Rheumatol Online J 2020 Apr 15;18(1):31. Epub 2020 Apr 15.

Joseph M Sanzari Children's Hospital, Hackensack Meridian Health, Hackensack, NJ, USA.

Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. There is considerable heterogeneity in management strategies and a lack of evidence-based treatment guidelines. Consensus treatment plans (CTPs) are standardized treatment regimens that are derived based upon best available evidence and current treatment practices that are a way to enable comparative effectiveness studies to identify optimal therapy and are less costly to execute than randomized, double blind placebo controlled trials. Read More

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http://dx.doi.org/10.1186/s12969-020-00424-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157990PMC

Substantiation of diagnosis and treatment of chronic recurrent aphthous stomatitis in crohn's disease.

Wiad Lek 2020 ;73(3):512-516

Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine.

Objective: The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn's disease.

Patients And Methods: Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn's disease (main group), mean age 31.8 + 2. Read More

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Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis

Endocr Metab Immune Disord Drug Targets 2020 04 12. Epub 2020 Apr 12.

Ondokuz Mayıs University, Faculty of Veterinary Medicine, Department of Pathology, Samsun. Turkey.

Background/aims: Recurrent aphthous stomatitis (RAS) is one of common oral inflammatory diseases. As immunological and genetic factors have been held in the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk.

Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Read More

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http://dx.doi.org/10.2174/1871530320666200413092239DOI Listing

Value of colchicine as treatment for recurrent oral ulcers: A systematic review.

J Oral Pathol Med 2020 Apr 13. Epub 2020 Apr 13.

Oral Medicine Section, Department of Surgical Sciences, CIR-Dental School, University of Turin, Turin, Italy.

Background: In oral medicine, colchicine is a therapeutic alternative for idiopathic recurrent aphthous stomatitis (RAS), Behçet disease (BD), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome, and mouth and genitals ulcers with inflamed cartilage (MAGIC) syndrome. The present review aims to evaluate reliability of colchicine against recurrent oral ulcers.

Methods: A systematic review was conducted, with the following PICO (Patient, Intervention, Control, Outcome) question: "In populations with idiopathic or secondary recurrent oral ulcers, is colchicine more effective in improving pain and accelerating healing, compared to other intervention or placebo?"

Results: Seven RCTs and 3 OCTs were considered eligible. Read More

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http://dx.doi.org/10.1111/jop.13020DOI Listing
April 2020
1.870 Impact Factor

Long-term management of patients with PFAPA syndrome.

Eur Arch Otorhinolaryngol 2020 Aug 1;277(8):2335-2339. Epub 2020 Apr 1.

Department of Otorhinolaringology, Healty Science University Hospital, Afyonkarahisar, Turkey.

Objective: To evaluate the long-term treatment results of patients with PFAPA syndrome and to determine their need for tonsillectomy.

Materials And Methods: The clinical characteristics, treatments and long-term results of 16 patients admitted to the Pediatric and Otorhinolaryngology Clinic between 2015 and 2019 were retrospectively analyzed.

Results: Twelve male and four female patients were examined between 1. Read More

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http://dx.doi.org/10.1007/s00405-020-05943-7DOI Listing

[Benign pathologies of the oral mucosa].

Rev Prat 2019 Oct;69(8):850-855

Service de stomatologie et chirurgie maxillofaciale, groupe hospitalier Pitié-Salpêtrière, Paris, France.

Benign pathologies of the oral mucosa. An overview of some common benign oral diseases whose diagnostic orientation begins and is based primarily on a precise clinical analysis. Canker sores and benign traumatic ulcers must not make a novice carcinoma go unnoticed. Read More

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October 2019

Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment.

Nanomaterials (Basel) 2020 Mar 28;10(4). Epub 2020 Mar 28.

CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1. Read More

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http://dx.doi.org/10.3390/nano10040628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221765PMC

Recurrence of Symptoms Associated with Menstruation in a Patient with a History of Periodic Fevers.

J Pediatr Adolesc Gynecol 2020 Mar 26. Epub 2020 Mar 26.

Department of Adolescent Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York. Electronic address:

Background: Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome is a cyclic autoinflammatory disease generally diagnosed in childhood. There have been studies suggesting a relationship between menstruation and other autoinflammatory syndromes such as familial Mediterranean fever (FMF), but not PFAPA specifically.

Case: This case describes a patient with a diagnosis of PFAPA who experienced complete resolution with tonsillectomy only to have recurrence of symptoms with onset of menstruation. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.03.008DOI Listing

Oral lesions as first clinical manifestations of Crohn's disease in paediatric patients: a report on 8 cases.

Eur J Paediatr Dent 2020 Mar;21(1):66-69

Department of Interdisciplinary Medicine, Aldo Moro University Bari, Italy.

Aim: Oro-facial granulomatosis is a descriptive term commonly encompassing a variety of conditions that exhibit similar clinical and microscopic features. It is generally used to describe persistent enlargement of the soft tissues of the oral and maxillofacial region.

Materials And Methods: We report on the salient clinical features of 8 cases of Crohn's disease in paediatric patients (age range from 9 to 13 years old), with oral lesions as first clinical manifestations. Read More

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http://dx.doi.org/10.23804/ejpd.2020.21.01.13DOI Listing

Mean Platelet Volume, Neutrophil-To-Lymphocyte Ratio, and Platelet-To-Lymphocyte Ratio as İnflammatory Markers in patients with Recurrent Aphthous Stomatitis.

Eurasian J Med 2020 Feb;52(1):38-40

Department of Otolaryngology, Malatya Training and Research Hospital, Malatya, Turkey.

Objective: The aim of this study is to examine the associations between white blood cell (WBC), hemoglobin (Hb), neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels in patients with recurrent aphthous stomatitis (RAS).

Materials And Methods: For this study, 137 patients with RAS and 137 healthy controls were recruited. The study participants had no systemic diseases except RAS. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2019.18486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051240PMC
February 2020

Validation of the new classification criteria for hereditary recurrent fever in an independent cohort: experience from the JIR Cohort Database.

Rheumatology (Oxford) 2020 Mar 3. Epub 2020 Mar 3.

National Referral Centre of Auto-Inflammatory Diseases and Inflammatory Amyloidosis, - CEREMAIA, Department of Pediatrics, Versailles Hospital, Le Chesnay.

Objective: The new classification criteria for the hereditary recurrent fever (HRF) syndrome [cryopyrin-associated periodic syndrome (CAPS), TNF-α receptor-associated periodic syndrome (TRAPS), FMF and mevalonate kinase deficiency] have been published recently. These criteria define two core sets of criteria for each HRF: mixed criteria, including genetic and clinical variables, and clinical criteria, relying on clinical variables only. Our aim was to validate the criteria for HRF in an independent cohort, the JIR Cohort database, an international repository of systemic inflammatory diseases. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa031DOI Listing

Primary Idiopathic Complex Aphthosis: Diagnosis and Successful Treatment with Montelukast in a 44-Year-Old Filipino Female.

Case Rep Dermatol 2020 Jan-Apr;12(1):12-18. Epub 2020 Feb 4.

Skin and Cancer Foundation, Inc., Pasig City, Philippines.

Recurrent aphthous stomatitis (RAS) is an oral condition characterized by frequent attacks of painful oral ulcers. Complex aphthosis (CA) is a severe form of RAS described as the almost constant presence of ≥3 oral ulcers with or without genital aphthosis. Management of primary CA varies, but most patients warrant the use of systemic agents. Read More

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http://dx.doi.org/10.1159/000505475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036591PMC
February 2020

Isolated brachial artery aneurysm successfully treated with a covered stent in a patient with Behçet's disease.

Turk Gogus Kalp Damar Cerrahisi Derg 2019 Oct 23;27(4):565-567. Epub 2019 Oct 23.

Department of Cardiovascular Surgery, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Behçet's disease is a vasculitic pathology characterized by skin lesions, genital ulcers, aphthous stomatitis, and uveitis. Arterial aneurysms are rare in this disease. Herein, we report a rare case of an isolated brachial artery aneurysm with a history of Behçet's disease treated with endovascular covered stenting of the brachial artery. Read More

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http://dx.doi.org/10.5606/tgkdc.dergisi.2019.17852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018166PMC
October 2019

Diagnostic Rate of Autoinflammatory Diseases Evaluated by Fever Patterns in Pediatric- and Adult-Onset Patients.

J Clin Rheumatol 2020 Mar;26(2):60-62

From the Institute of Rheumatology.

Objectives: This is a noncomparative study performed to determine if fever pattern is related to a diagnosis of autoinflammatory disease (AID) in pediatric- and adult-onset patients.

Methods: The final diagnosis of patients suspected to have AID was evaluated against gene polymorphisms known to be responsible for AID, clinical manifestations, and fever pattern, in our institute from 2005 to 2016. Genomic DNA was isolated from patients' peripheral blood, and polymerase chain reaction was used to amplify the indicated exons of 12 genes: MEFV, TNFRSF1A, MVK, NLRP3, NOD2, LI1RN, IL36RN, PSMB8, NALP12, PSTPIP1, TNFAIP3, and NLRC4. Read More

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http://dx.doi.org/10.1097/RHU.0000000000000929DOI Listing

[AN ADULT CASE OF PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND ADENITIS (PFAPA) SYNDROME DEVELOPED IN CHILDHOOD AND DIAGNOSED AFTER PROGRESS MORE THAN 30 YEARS].

Arerugi 2020 ;69(1):53-58

Department of Molecular and Cellular Immunology, School of Medicine, Shinshu University.

We report an adult case of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, who had a tonsillectomy at 10 years old and relapsed later. An early 40's-year-old man had been suffering from recurrent fever attack once in 1-2 months during childhood. He was accompanied by fever which was persist for several days, aphthous stomatitis, tongued tonsillitis with moss, pharyngitis, and submandibular lymphadenitis with tenderness. Read More

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http://dx.doi.org/10.15036/arerugi.69.53DOI Listing

Effectiveness of virtual patients in teaching clinical decision-making skills to dental students.

J Dent Educ 2020 May 10;84(5):615-623. Epub 2020 Feb 10.

Virtual School, and Center of Excellence for e-Learning in Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: The aim of this study was to investigate the effect of virtual patient-based training on the clinical decision-making ability of dental students.

Methods: This quasi-experimental study with pretest and posttest design was conducted on 76 (2015 admitted) dental students of Shiraz Dental School in 2018-2019. The study samples were randomly divided into 2 groups: intervention (web-based virtual patient training = 36) and control (face-to-face case-based training, n = 40). Read More

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http://dx.doi.org/10.1002/jdd.12045DOI Listing

Depression symptoms and recurrent aphthous stomatitis-Evidence from a population-based study in Indonesia.

Oral Dis 2020 Jul 21;26(5):948-954. Epub 2020 Feb 21.

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Objectives: This study aims to report the prevalence and distribution of recurrent aphthous stomatitis (RAS) among Indonesian adults and to test the relationship between symptom of depression and RAS.

Methods: Data from the 2007 Indonesia Family Life Survey (IFLS 2007) were analysed to assess the association between symptom of depression and RAS. The prevalence of RAS in the previous month was self-reported. Read More

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http://dx.doi.org/10.1111/odi.13303DOI Listing

Do Heavy Metals Accumulated in Saliva Involve in the Etiopathogenesis of Recurrent Aphthous Stomatitis?

Biol Trace Elem Res 2020 Feb 6. Epub 2020 Feb 6.

Faculty of Medicine, Department of Dermatology, Istanbul Medeniyet University, Istanbul, Turkey.

Recurrent aphthous stomatitis (RAS) is one of the most common diseases of oral mucosa characterized by recurrent painful ulcers. Although many factors have been implicated in its etiology, they are not fully identified. To investigate the involvement of heavy metals accumulated in saliva in the etiopathogenesis of RAS. Read More

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http://dx.doi.org/10.1007/s12011-020-02058-2DOI Listing
February 2020

[Clinical case of levamisole-induced multifocal inflammatory leukoencephalopathy].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(12):106-114

Bujanov Moscow City Clinical Hospital, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia.

Levamisole is an immunomodulatory drug which can trigger development of levamisole-induced multifocal inflammatory leukoencephalopathy (LIMIL) in patients treated for helminthic invasion, aphthous stomatitis, cancer, or cocaine users. LIMIL clinical case in patient 45 years old after single dose of levamisole (taken without any medical prescription) was described. We presented clinical history and clinical picture, MRI and laboratory data and treatment results during 1-year observation. Read More

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http://dx.doi.org/10.17116/jnevro2019119121106DOI Listing
January 2020

Mosaic Small Supernumerary Marker Chromosome Derived from Five Discontinuous Regions of Chromosome 8 in a Patient with Neutropenia and Oral Aphthous Ulcer.

Cytogenet Genome Res 2020 24;160(1):11-17. Epub 2020 Jan 24.

Small supernumerary marker chromosomes (sSMCs) are characterized as additional centric chromosome fragments which are too small to be classified by cytogenetic banding alone and smaller than or equal to the size of chromosome 20 of the same metaphase spread. Here, we report a patient who presented with slight neutropenia and oral aphthous ulcers. A mosaic de novo sSMC, which originated from 5 discontinuous regions of chromosome 8, was detected in the patient. Read More

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http://dx.doi.org/10.1159/000505805DOI Listing

Salivary levels of IgE and ECP in patients with recurrent aphthous stomatitis.

J Clin Exp Dent 2020 Jan 1;12(1):e9-e12. Epub 2020 Jan 1.

Dentist, Zahedan University of Medical Sciences, Zahedan, Iran.

Background: Recurrent aphthous stomatitis is a common oral mucosa disease, with no specific etiology. Atopy has been implicated in the development of this disease. In this study, the salivary levels of immunoglobulin E (IgE) and eosinophil cationic protein (ECP) were measured as allergy-related biomarkers in patients with aphthous stomatitis. Read More

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http://dx.doi.org/10.4317/medoral.56254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969959PMC
January 2020

Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis.

J Oral Pathol Med 2020 Mar 7;49(3):271-277. Epub 2020 Feb 7.

Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background: The development of recurrent aphthous stomatitis (RAS), inflammatory disease of oral mucosa, is influenced by both environmental and genetic factors. The aim of this study was to investigate polymorphisms located in seven genes coding different types of matrix metalloproteinases (MMPs)-collagenases (MMP1, MMP8, and MMP13), gelatinases (MMP2 and MMP9), stromelysin (MMP3), and membrane-type metalloproteinase (MMP16) in patients with RAS and healthy controls.

Methods: Totally, 223 subjects were included in this case-control study and their detailed anamnestic, clinical, and laboratory parameters were recorded. Read More

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http://dx.doi.org/10.1111/jop.12993DOI Listing

Celiac disease and hematological abnormalities in children with recurrent aphthous stomatitis.

Pediatr Int 2020 Jun 11;62(6):705-710. Epub 2020 Jun 11.

Department of Pediatrics, Turkish Republic Health Ministry, Ankara Child Health Diseases, Hematology and Oncology Training and Research Hospital, Ankara, Turkey.

Background: Recurrent aphthous stomatitis (RAS) is one of the most common diseases of the oral mucosa and may be related to vitamin deficiencies or systemic diseases such as celiac disease (CD). The aim of this study was to investigate the frequency of hematinic deficiency and CD in children with RAS.

Methods: The medical records of patients diagnosed with RAS were reviewed for the presence of hematinic deficiencies (hemoglobin, mean corpuscular volume, ferritin, vitamin B , folic acid), and CD. Read More

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http://dx.doi.org/10.1111/ped.14155DOI Listing

Probiotics for recurrent idiopathic aphthous stomatitis in adults: a placebo-controlled randomized trial.

J Eur Acad Dermatol Venereol 2020 May 16;34(5):e239-e240. Epub 2020 Feb 16.

Service de Dermatologie, Centre Hospitalier Universitaire Nice, Université Côte d'Azur, Nice, France.

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http://dx.doi.org/10.1111/jdv.16199DOI Listing

Chapter 6: Vitamins and Oral Health.

Monogr Oral Sci 2020 7;28:59-67. Epub 2019 Nov 7.

Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, Indiana, USA.

Vitamins are essential organic compounds that catalyze metabolic reactions. They also function as electron donors, antioxidants or transcription effectors. They can be extracted from food and supplements, or in some cases, synthesized by our body or gut microbiome. Read More

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http://dx.doi.org/10.1159/000455372DOI Listing
January 2020

LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence.

BMC Oral Health 2020 Jan 14;20(1):12. Epub 2020 Jan 14.

Department of Stomatology, Shanghai Baoshan Traditional Chinese Medicine-Integrated Hospital, Shanghai, 201900, People's Republic of China.

Background: Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown molecular pathogenesis. Our preliminary microarray analysis revealed the altered expression of lncRNA Cancer Susceptibility Gene 2 (CASC2) in RAS. We therefore analyzed the role of CASC2 in RAS. Read More

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http://dx.doi.org/10.1186/s12903-019-0993-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961228PMC
January 2020

Validation of the HADS and PSS-10 and a cross-sectional study of psychological status in patients with recurrent aphthous stomatitis.

J Oral Pathol Med 2020 Mar 22;49(3):260-270. Epub 2020 Jan 22.

UCL Eastman Dental Institute, London, UK.

Objectives: To validate the Hospital Anxiety and Depression Scale (HADS) and the 10-item Perceived Stress Scale (PSS-10) for use in clinical studies of recurrent aphthous stomatitis (RAS) and to provide cross-sectional assessment of anxiety, depressive, and distress symptoms and perceived stress in patients with RAS.

Methods: The validity and reliability of the HADS and PSS-10 were evaluated in 120 individuals with RAS through confirmatory factor analysis and calculation of Cronbach's alpha and omega coefficients. The prevalence of comorbid anxiety, depression, distress, and moderate-to-high perceived stress, and their association with demographics and clinical factors were assessed through cutoff scores of the HADS and PSS-10 and bivariate analyses, respectively. Read More

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http://dx.doi.org/10.1111/jop.12991DOI Listing