3,782 results match your criteria Aphthous Stomatitis


Recurrent Aphthous Stomatitis Caused by Cytomegalovirus, Herpes Simplex Virus, and Candida Species in a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2019 Apr 26;51(3):993-997. Epub 2019 Jan 26.

Department of Urology, Kyoto University Hospital, Kyoto, Japan.

Recipients of organ transplants are immunosuppressed and at high risk of oral infection. Oral diseases are often neglected compared with infections of other organs that typically confer higher morbidity. However, severe local symptoms hinder oral intake, decrease quality of life, and are sometimes lethal. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.058DOI Listing

Adalimumab in the treatment of pediatric Behçet's disease: case-based review.

Rheumatol Int 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatric Rheumatology, National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan.

Behçet's disease (BD) is a systemic vasculitis affecting prominently the veins, which is usually diagnosed in adulthood, but can occur in children younger than 16 years in about 4-26% of cases. The therapy is based on several immune-suppressive drugs; in case of inadequate control and/or complications, the biologic therapy with anti-TNF drugs has been successfully used in adults. Here, we reported one pediatric case of BD with systemic (persistent/recurrent high fever), skin and mucosal manifestations (recurrent aphthous stomatitis, anal/penile ulcers, erythema nodosum and papulo-pustules), that were unresponsive to the conventional treatment with steroids and colchicine; however, he was successfully treated with adalimumab. Read More

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http://dx.doi.org/10.1007/s00296-019-04300-0DOI Listing
April 2019
2 Reads

Adhesive alginate for buccal delivery in aphthous stomatitis.

Carbohydr Res 2019 Mar 29;477:51-57. Epub 2019 Mar 29.

Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.

Background: Recurrent aphthous stomatitis being the most common chronic disease of the oral cavity affects 5-25% of the population.

Aim: This study goals to develop a novel polymeric excipient based on alginate with enhanced mucoadhesion and controlled release for buccal therapy of aphthae.

Methods: Sulfhydryl groups of amino acid cysteine (SH) was anchored on the polymeric backbone of alginate (AL). Read More

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http://dx.doi.org/10.1016/j.carres.2019.03.009DOI Listing

From uncertainty to gradually managing and awaiting recovery of a periodic condition- a qualitative study of parents´ experiences of PFAPA syndrome.

BMC Pediatr 2019 Apr 8;19(1):99. Epub 2019 Apr 8.

Department of Pediatrics, NU-Hospital Group, Uddevalla, Sweden.

Background: The prevalence of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is unknown. Although an uncommon condition, it is considered to be the most common autoinflammatory disease among children in many parts of the world. The knowledge of the consequences of the recurrent fever episodes for the child and its family are limited. Read More

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http://dx.doi.org/10.1186/s12887-019-1458-yDOI Listing

Periodic Fever with Pharyngitis, Aphthous Stomatitis and Cervical Adenitis Syndrome: A Rare Cause of Fever in Adults.

Eur J Case Rep Intern Med 2019 8;6(3):001041. Epub 2019 Mar 8.

Internal Medicine Department, Hospital de Egas Moniz, Lisbon, Portugal.

Periodic fever with pharyngitis, aphthous stomatitis and cervical adenitis (PFAPA syndrome) is a common cause of periodic fever in children and usually manifests as episodes of fever recurring with a clockwork periodicity. Although rare after adolescence, adult patients with PFAPA syndrome may present with a wider range of symptoms and may lack the clockwork periodicity of fever. A 24-year-old patient presented with a 4-year history of periodic fever with pharyngitis and cervical adenitis. Read More

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http://dx.doi.org/10.12890/2019_001041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438113PMC

Beta-defensin 1 gene polymorphisms at 5' untranslated region are not associated with a susceptibility to recurrent aphthous stomatitis.

Arch Oral Biol 2019 May 25;101:130-134. Epub 2019 Mar 25.

Department of Gerodontology and Oral Pathology, University of Medical Sciences, Poznan, Poland.

Objective: The purpose of this study was to evaluate the possible association between two single nucleotide polymorphisms of the β-defensin 1 gene: -20 G > A and -44 C > G at 5 untranslated region and recurrent aphthous stomatitis in a cohort of Polish patients.

Design: One hundred and six patients suffering from recurrent aphthous stomatitis and 96 healthy volunteers were genotyped at β-defensin 1-20 G > A and -44 C > G using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The results were statistically analysed with the difference test between two proportion and chi-square tests with p < 0. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.03.016DOI Listing
May 2019
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Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.

Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205

15 Department of Research and Quality, American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

Objective: This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation provides evidence-based recommendations on the pre-, intra-, and postoperative care and management of children 1 to 18 years of age under consideration for tonsillectomy. Tonsillectomy is defined as a surgical procedure performed with or without adenoidectomy that completely removes the tonsil, including its capsule, by dissecting the peritonsillar space between the tonsil capsule and the muscular wall. Tonsillectomy is one of the most common surgical procedures in the United States, with 289,000 ambulatory procedures performed annually in children <15 years of age, based on the most recent published data. Read More

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http://dx.doi.org/10.1177/0194599818807917DOI Listing
February 2019
1 Read

Diagnostic Value of Neutrophil-Lymphocyte Ratios and Mean Platelet Volumes in the Activation of Recurrent Aphthous Stomatitis.

Indian J Otolaryngol Head Neck Surg 2019 Mar 12;71(1):120-123. Epub 2017 Jan 12.

Department of Otorhinolaryngology, Van Training and Research Hospital, Van, Turkey.

Recurrent aphthous stomatitis (RAS) is associated with endothelial dysfunction and chronic inflammation. The neutrophil-to-lymphocyte ratio (NLR) and mean platelet voume (MPV) are markers of inflammation and endothelial dysfunction, respectively. In the present report, we discuss the NLR and MPV values of patients with active and inactive RAS. Read More

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http://link.springer.com/10.1007/s12070-017-1059-8
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http://dx.doi.org/10.1007/s12070-017-1059-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401059PMC
March 2019
4 Reads

Towards better diagnostic criteria for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome.

Acta Paediatr 2019 Mar 22. Epub 2019 Mar 22.

PEDEGO Research Unit, University of Oulu, Oulu, Finland.

Aim: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most common cause of a periodic fever in childhood. The exact pathogenesis and the aetiology of PFAPA are still unknown.

Methods: We conducted a non-systematic review of published articles about PFAPA syndrome and summarised the evidence for diagnostic criteria and treatment options for PFAPA. Read More

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http://dx.doi.org/10.1111/apa.14792DOI Listing

Serum thyroid autoantibodies are not associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in patients with Behcet's disease.

J Dent Sci 2018 Sep 7;13(3):256-262. Epub 2018 Jun 7.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.

Background/purpose: Our previous study found that 13 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity (TGA/TMA positivity) but without gastric parietal cell antibody positivity. This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in TGA/TMA-positive RAS/BD patients.

Materials And Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 13 TGA/TMA-positive RAS/BD patients and 41 gastric and thyroid antibodies-negative RAS/BD patients (Abs־RAS/BD patients) or 126 healthy control subjects. Read More

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http://dx.doi.org/10.1016/j.jds.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388837PMC
September 2018
3 Reads

Frequencies of abnormal humoral and cellular immune component levels in peripheral blood of patients with recurrent aphthous ulceration.

J Dent Sci 2018 Jun 10;13(2):124-130. Epub 2017 Nov 10.

Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background/purpose: Recurrent aphthous ulceration (RAU) has an incidence of approximately 20% in general population. However, its exact cause remains unknown. Increasing evidence suggests that immunologic mechanisms may play crucial roles in the etiology of this disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19917902173013
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http://dx.doi.org/10.1016/j.jds.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388805PMC
June 2018
3 Reads

Mediterranean fever gene variants and colchicine therapy in periodic fever, aphthous stomatitis pharyngitis, adenitis syndrome in a Mediterranean region.

Expert Rev Clin Immunol 2019 May 19;15(5):571-575. Epub 2019 Mar 19.

b Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Disease , Cukurova University , Adana , Turkey.

Objectives: Periodic fever, aphthous stomatitis, pharyngitis, adenitis syndrome is characterized by recurrent episodes of fever. Attenuated disease severity was considered in patients with Mediterranean fever (MEFV) gene variations. Corticosteroids are highly effective in controlling the symptoms but usually cause more frequent episodes. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1591275DOI Listing
May 2019
2 Reads

Vitamin D deficiency as a risk factor for PFAPA syndrome.

Int J Pediatr Otorhinolaryngol 2019 Mar 4;121:55-57. Epub 2019 Mar 4.

Namık Kemal University Department of Pediatrics, Tekirdağ, Turkey. Electronic address:

Objective: The periodic fever, aphthous stomatitis, pharangytis and cervical adenitis (PFAPA) syndrome, is an idiopathic chronic disease of non-hereditary origin, primarily affecting pre-school children and is the most common periodic fever disorder in children. Rapid response to corticosteroid treatment suggest an immune dysregulation. Recently, emerging evidence suggest that vitamin D plays an important role in immunity regulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193011
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http://dx.doi.org/10.1016/j.ijporl.2019.02.047DOI Listing
March 2019
14 Reads

Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: A systematic review.

J Oral Pathol Med 2019 Mar 6. Epub 2019 Mar 6.

Department of Oral and Maxillofacial Pathology/Biology, Lagos University Teaching Hospital, Lagos, Nigeria.

The present systematic review sought to evaluate the effects of Sodium Lauryl Sulfate (SLS)-free compared to SLS-containing dentifrices on (Recurrent) aphthous stomatitis (RAS) in patients with this condition. Cochrane, Medline (PubMed) and Embase databases, and some trial registries were searched through December 2017. There was no language, nor publication year restrictions. Read More

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http://dx.doi.org/10.1111/jop.12845DOI Listing
March 2019
2 Reads

Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.

Nat Commun 2019 03 5;10(1):1052. Epub 2019 Mar 5.

Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461,106) heritability is estimated at 8. Read More

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http://www.nature.com/articles/s41467-019-08923-6
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http://dx.doi.org/10.1038/s41467-019-08923-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400940PMC
March 2019
6 Reads

Pediatric Celiac Disease - A Review.

S D Med 2018 Dec;71(12):559-564

Sanford Children's Hospital, Sioux Falls, South Dakota.

Our understanding of celiac disease is rapidly expanding. Previously thought to be a rare food intolerance, celiac disease is now recognized as a multifactorial autoimmune disorder with a vast array of presentations. Symptoms range from classic diarrhea, weight loss, and abdominal pain to constipation and extra-intestinal manifestations including anemia, elevated transaminase levels, osteoporosis, or aphthous stomatitis. Read More

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December 2018
2 Reads

Azithromycin-induced aphthous stomatitis: a case series.

Curr Clin Pharmacol 2019 Mar 1. Epub 2019 Mar 1.

Clinical Pharmacy Department, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Background: Azithromycin is one the most popular antibiotics in current clinical practice. This medication generally considered to be safe and well-tolerated in different demographic populations. Like any other drug, azithromycin use is not without risk and adverse effects. Read More

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http://dx.doi.org/10.2174/1574884714666190301153040DOI Listing
March 2019
1 Read

Oxidative Stress and Oral Mucosal Diseases: An Overview.

In Vivo 2019 Mar-Apr;33(2):289-296

Section of Dentistry, Interdisciplinary Department of Medicine, School of Medicine, Aldo Moro University of Bari, Bari, Italy

Background: Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. Read More

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http://dx.doi.org/10.21873/invivo.11474DOI Listing
November 2018
1 Read

Clinical Practice Guideline: Tonsillectomy in Children (Update).

Otolaryngol Head Neck Surg 2019 Feb;160(1_suppl):S1-S42

15 Department of Research and Quality, American Academy of Otolaryngology-Head and Neck Surgery Foundation, Alexandria, Virginia, USA.

Objective: This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and Neck Surgery Foundation provides evidence-based recommendations on the pre-, intra-, and postoperative care and management of children 1 to 18 years of age under consideration for tonsillectomy. Tonsillectomy is defined as a surgical procedure performed with or without adenoidectomy that completely removes the tonsil, including its capsule, by dissecting the peritonsillar space between the tonsil capsule and the muscular wall. Tonsillectomy is one of the most common surgical procedures in the United States, with 289,000 ambulatory procedures performed annually in children <15 years of age based on the most recent published data. Read More

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http://dx.doi.org/10.1177/0194599818801757DOI Listing
February 2019
2 Reads

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: main features and an algorithm for clinical practice.

Authors:
Ezgi Deniz Batu

Rheumatol Int 2019 Feb 23. Epub 2019 Feb 23.

Division of Rheumatology, Department of Pediatrics, Ankara Training and Research Hospital, University of Health Sciences, 06100, Ankara, Turkey.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a recurrent fever syndrome of early childhood with increasing number of adult-onset cases. Although it is a self-limited disease, it may negatively affect the quality of life. The aim of this review is to present a detailed analysis of PFAPA syndrome and an algorithm for diagnosis, therapeutic options, and evaluation of outcome. Read More

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http://link.springer.com/10.1007/s00296-019-04257-0
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http://dx.doi.org/10.1007/s00296-019-04257-0DOI Listing
February 2019
1 Read

Evaluation of salivary tumour necrosis factor-alpha in patients with recurrent aphthous stomatitis.

Eur Oral Res 2018 Sep 1;52(3):157-161. Epub 2018 Sep 1.

Department of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, India.

Purpose: Present study was undertaken to evaluate and compare the salivary levels of tumour necrosis factor alpha (TNF-α) in subjects with RAS, traumatic ulcers (TUs) in the oral mucosa and in healthy controls.

Materials And Methods: Present study involved 90 participants of which 30 subjects were diagnosed with RAS, 30 subjects with TUs and 30 healthy controls grouped as group 1, group 2 and group 3 respectively. Unstimulated saliva was collected from the subjects through 'Spit Technique' and the estimation of TNF-α was done by enzyme linked immunosorbent assay. Read More

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http://dx.doi.org/10.26650/eor.2018.543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365135PMC
September 2018
1 Read

Clinical evaluation of dental enamel defects and oral findings in coeliac children.

Eur Oral Res 2018 Sep 1;52(3):150-156. Epub 2018 Sep 1.

Department of Basic Medical Sciences, Division of Biochemistry, Marmara University, Faculty of Dentistry, İstanbul, Turkey.

Purpose: To examine dental hard and soft tissue changes of coeliac children in order to increase the awareness of the pediatric dentists in prediagnosis of especially undiagnosed coeliac disease.

Materials And Methods: Sixty children, 28 (46.7%) boys and 32 (53. Read More

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http://eor.istanbul.edu.tr/en/yazi/10-26650-eor-2018-525-510
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http://dx.doi.org/10.26650/eor.2018.525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365134PMC
September 2018
5 Reads

Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients.

Pediatr Int 2019 Jan;61(1):104-106

Second Department of Paediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.

The aim of this study was to compare the immunogenicity and side-effects of hepatitis A virus (HAV) vaccination between periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) patients and healthy controls who have not been previously exposed to HAV. A prospective observational study was carried out of 28 PFAPA patients and 76 controls who received two doses of the vaccine. Immunogenicity was expressed as seroconversion and seroprotection rates; mean HAV-immunoglobulin G concentration was measured at 0, 1, 7 and 18 months. Read More

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http://dx.doi.org/10.1111/ped.13719DOI Listing
January 2019
2 Reads

Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis.

Recent Pat Drug Deliv Formul 2018 ;12(4):277-294

Department of Pharmaceutics, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial (ASBASJSM) College of Pharmacy, Bela, Ropar, Punjab 140111, India

Background: During the recent two decades, the development of mucoadhesive drug delivery system has been gained tremendous importance to cure many recurrent diseases of the oral cavity. The drug delivery through the buccal route is quite challenging due to limited absorption area, movements of the target region and regular flow of saliva lead to the sub-therapeutic drug level in the buccal region.

Objective: The aim is to develop unidirectional release mucoadhesive buccal film for the mucosal delivery of Benzydamine Hydrochloride (WO2016126217Al, EP0812193B1) and evaluate the effects of a different grade of HPMC polymer (US5980942A) with the presumption to prolong the residence time and therapeutic effectiveness at the target site. Read More

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http://dx.doi.org/10.2174/1872211313666190128151038DOI Listing
January 2018
6 Reads

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review.

Head Neck Pathol 2019 Mar 7;13(1):91-102. Epub 2019 Mar 7.

Department of Diagnostic and Biomedical Sciences, University of Texas at Houston Health Science Center School of Dentistry, Houston, TX, USA.

Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Read More

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http://dx.doi.org/10.1007/s12105-018-0981-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405793PMC
March 2019
2 Reads

Search for Drugs Used in Hospitals to Treat Stomatitis.

Medicines (Basel) 2019 Jan 29;6(1). Epub 2019 Jan 29.

Meikai University Research Institute of Odontology (M-RIO), 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan.

Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Read More

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http://dx.doi.org/10.3390/medicines6010019DOI Listing
January 2019
2 Reads

Imerslund-Gräsbeck Syndrome in an Infant with a Novel Intronic Variant in the Gene: A Case Report.

Int J Mol Sci 2019 Jan 27;20(3). Epub 2019 Jan 27.

Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129 Perugia, Italy.

Imerslund-Gräsbeck syndrome (IGS) is a rare autosomal recessive disorder clinically characterized by megaloblastic anemia, benign mild proteinuria, and other nonspecific symptoms. Several pathogenetic variants in the amnionless () or cubilin () genes have been described in IGS. We describe a case of IGS with urinary tract infection and mild but persistent proteinuria at onset in an 11-month-old female child. Read More

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http://dx.doi.org/10.3390/ijms20030527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387074PMC
January 2019
3 Reads

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome - PFAPA syndrome.

Authors:
Per Wekell

Presse Med 2019 Feb 22;48(1 Pt 2):e77-e87. Epub 2019 Jan 22.

Department of Pediatrics, NU-Hospital Group, 45180 Uddevalla, Sweden; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a complex autoinflammatory disease with a clinical phenotype characterised by recurrent episodes of fever, systemic inflammation and symptoms and signs depicted in disease acronym. Although PFAPA is the most common autoinflammatory disease among children in many parts of the world, the condition is still an enigma, which include the regular episodes, the prompt responses to corticosteroids, the genetic bases for the familial clustering and therapeutic effects of tonsillectomy. This review explores PFAPA syndrome with the aim of describing the current clinical and scientific understanding of the condition. Read More

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http://dx.doi.org/10.1016/j.lpm.2018.08.016DOI Listing
February 2019
2 Reads

[Relationship between nuclear factor-κB signaling pathway and susceptibility of recurrent aphthous ulcer].

Shanghai Kou Qiang Yi Xue 2018 Oct;27(5):513-517

Department of Endodontics, Stomatological Hospital of Ningxia Medical University General Hospital. Yinchuan 750004, Ningxia Hui Autonomous Region, China.

Purpose: To explore the possible relationship between recurrent aphthous ulcer (RAU) and nuclear factor-κB signaling pathway.

Methods: A total of 124 RAU patients were recruited for this study. The control group consisted of 133 healthy subjects. Read More

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October 2018
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Comparing Serum and Salivary Levels of Vitamin D in Patients with Recurrent Aphthous Stomatitis and Healthy Individuals.

J Dent (Shiraz) 2018 Dec;19(4):295-300

Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Statement Of The Problem: Recurrent aphthous stomatitis (RAS) is the most prevalent ulcerative condition of the oral mucosa. Many studies have emphasized on immunologic factors as the reason of inducing RAS; however, the exact etiologic cause of RAS has not been identified yet. Vitamin D has an endocrine function and regulatory effects on the immune system. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338692PMC
December 2018
18 Reads

Serum levels of total antioxidant status, nitric oxide and nitric oxide synthase in minor recurrent aphthous stomatitis patients.

Medicine (Baltimore) 2019 Jan;98(3):e14039

Department of Stomatology, the 980th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Shijiazhuang.

Background: Recurrent aphthous stomatitis (RAS) is one of the most common inflammatory ulcerative conditions of oral cavity with uncertain etiology. Several studies have reported that oxidative stress may be associated with RAS. The aim of this study was to compare the serum levels of total antioxidant status (TAS), nitric oxide (NO) and nitric oxide synthase (NOS) in minor RAS (MiRAS) patients with healthy individuals and determine the possible association of MiRAS with the 3 physiological parameters mentioned above. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0002
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http://dx.doi.org/10.1097/MD.0000000000014039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370179PMC
January 2019
19 Reads

Psychometric analysis of stress, anxiety and depression in patients with recurrent aphthous Stomatitis-A cross-sectional survey based study.

J Clin Exp Dent 2018 Nov 1;10(11):e1109-e1114. Epub 2018 Nov 1.

Assistant Professor, Department of Oral Medicine and Radiology.

Background: Recurrent Aphthous Stomatitis is a chronic inflammatory immune mediated condition associated with single or multiple, painful recurring ulcers of the oral mucosa. Psychological stress is a common trigger factor identified for the onset and progression of this condition. The study aimed to evaluate stress, anxiety and depression using the Hospital Anxiety and Depression scale and stress by the General Health Questionnaire in subjects with Recurrent Aphthous Stomatitis (RAS). Read More

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http://dx.doi.org/10.4317/jced.55012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311397PMC
November 2018

Applications of Propolis in Dentistry: A Review.

Ethiop J Health Sci 2018 Jul;28(4):505-512

Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran; Oral and Maxillofacial Surgery Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Background: Propolis is a resinous substance obtained from the beehives that has antioxidant, anti-bacteria, anti-virus, anti-fungal, anti-tumor and anti-inflammatory activity. The aim of this study was to review the studies about the role of propolis in improving dental and oral health.

Methods: This study reviewed the published articles regarding the applications of propolis in dentistry. Read More

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http://dx.doi.org/10.4314/ejhs.v28i4.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308739PMC
July 2018
2 Reads

Use of Apremilast for Aphthous Ulcers in a Patient With Behçet’s Syndrome

J Drugs Dermatol 2018 12;17(12):1328-1329

Behçet’s syndrome is an inflammatory disease characterized by aphthous oral ulcers and several systemic manifestations, which include genital ulcers, ocular disease, skin lesions, arthritis, and vascular disease Read More

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December 2018
8 Reads

High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome.

J Med Biochem 2018 Dec 1;37(4):507-509. Epub 2018 Dec 1.

Department and Clinic of Paediatric Infectious Diseases, Wrocław Medical University, Wrocław, Poland.

PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). Read More

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http://dx.doi.org/10.1515/jomb-2017-0066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298472PMC
December 2018
1 Read

Low laser therapy as an effective treatment of recurrent aphtous ulcers: a clinical case reporting two locations.

Pan Afr Med J 2018 10;30:205. Epub 2018 Jul 10.

Department of Oral Surgery, Faculty of Dentistry, Mohamed V University, Rabat, Morocco.

Apthous ulcers, commonly referred to as canker sores, are the most common ulcerative lesions of the oral mucosa. These are usually painful and are associated with redness and occasional bleeding from the affected area(s). Low Level Laser Therapy (LLLT) has shown excellent results in relieving the pain and complete remission of the oral ulcers. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.205.15779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294968PMC
January 2019
11 Reads

Brainstem astrocytoma as a neuro-Behçet's disease mimic.

BMJ Case Rep 2018 Dec 7;11(1). Epub 2018 Dec 7.

Internal Medicine, Division of Rheumatology, New York University, New York City, New York, USA.

A 58-year-old man with a history of recurrent aphthous ulcers since childhood was admitted to the hospital with acute neurological decline characterised by loss of motor dexterity, dysarthria, dysphagia and unsteady gait. MRI brain was significant for symmetrical hyperintense T2 fluid attenuated inversion recovery (FLAIR) in the corticospinal tracts, including parts of the pons and the mesodiencephalic junction. Though initial concern was for neuro-Behçet's disease, brain biopsy ultimately revealed a diagnosis of astrocytoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-226945DOI Listing
December 2018

Chinese herbal medicine for recurrent aphthous stomatitis: a protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(50):e13681

Graduate School, Zhejiang Chinese Medical University, Hangzhou.

Background: Recurrent aphthous stomatitis (RAS) is the most frequent form of oral ulceration, characterized by recurrent oral mucosal ulceration in an otherwise healthy individual. This study was designed to evaluate the efficacy and safety of Chinese herbal medicine for recurrent aphthous stomatitis.

Methods: Five databases will be searched from inception to date, including PubMed, Cochrane Library, EMBASE,CNKI, and CBM. Read More

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http://dx.doi.org/10.1097/MD.0000000000013681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320145PMC
December 2018
1 Read

Kampo (Traditional Japanese Herbal) Formulae for Treatment of Stomatitis and Oral Mucositis.

Medicines (Basel) 2018 Dec 10;5(4). Epub 2018 Dec 10.

Department of physiology, School of medicine, Showa University, Tokyo 142-8555, Japan.

Stomatitis is occasionally multiple, recurrent, and refractory. Currently, mucositis induced by chemotherapy and radiation therapy in patients with cancer has become a significant clinical problem. Effective treatments have not been established and the treatment of numerous cases remains a challenge for physicians. Read More

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http://www.mdpi.com/2305-6320/5/4/130
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http://dx.doi.org/10.3390/medicines5040130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313652PMC
December 2018
15 Reads

Severe HIV-associated aphthous stomatitis treated with etanercept.

Med Mal Infect 2019 May 6;49(3):219-220. Epub 2018 Dec 6.

Inserm U1175, maladies infectieuses, CHU de Montpellier, 34295 Montpellier cedex 5, France. Electronic address:

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http://dx.doi.org/10.1016/j.medmal.2018.11.005DOI Listing
May 2019
1 Read

Establishment of Role of IL-2, IL-10 and IL-12 in Patients with Recurrent Aphthous Stomatitis-A Clinical Study.

J Contemp Dent Pract 2018 Oct 1;19(10):1242-1245. Epub 2018 Oct 1.

Department of Periodontics, DY Patil Dental School, Lohegaon, Pune, Maharashtra, India.

Background: Recurrent aphthous stomatitis is a vesiculobul-lous disease characterized by painful ulcers in the oral cavity. The role of interleukins such as IL-2, IL-10 and IL-12 in initiating disease demands careful assessment. The present study was conducted to determine the level of IL-2, IL-10 and IL-12 in patients with recurrent aphthous stomatitis. Read More

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October 2018
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Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review.

Clin Rheumatol 2019 Jan 28;38(1):11-17. Epub 2018 Nov 28.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most frequent non-hereditary autoinflammatory disorder in childhood: Its onset is usually observed before 5 years, though reports regarding adulthood are increasing. The pathogenesis of the syndrome is not completely understood, but a multifactorial origin, probably based on a polygenic pattern of susceptibility, is the most probable rational pathogenetic hypothesis. Treatment of PFAPA syndrome relies on the administration of low-dose corticosteroids, which promptly abort flares but cannot prevent subsequent disease episodes over time. Read More

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http://link.springer.com/10.1007/s10067-018-4361-2
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http://dx.doi.org/10.1007/s10067-018-4361-2DOI Listing
January 2019
20 Reads

Soft Tissue Disorders of the Mouth.

Emerg Med Clin North Am 2019 Feb;37(1):55-68

Department of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA. Electronic address:

Soft tissue disorders of the mouth encompass a wide expanse of pathophysiology. This article focuses on the identification, etiology, management, and complications of common infectious processes (candidiasis, dental caries, and herpes labialis), inflammatory lesions (sialolithiasis, oral lichen planus, and aphthous ulcer), and benign entities (bony tori and mucocele). Read More

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http://dx.doi.org/10.1016/j.emc.2018.09.006DOI Listing
February 2019
15 Reads

Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis.

Immunobiology 2019 Jan 2;224(1):75-79. Epub 2018 Nov 2.

Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade 11000, Serbia.

The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183017
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http://dx.doi.org/10.1016/j.imbio.2018.10.006DOI Listing
January 2019
15 Reads

Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management.

J Formos Med Assoc 2018 Nov 14. Epub 2018 Nov 14.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae. Clinically, three types of RAS, namely minor, major, and herpetiform types, can be identified. RAS more commonly affects labial mucosa, buccal mucosa, and tongue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183074
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http://dx.doi.org/10.1016/j.jfma.2018.10.023DOI Listing
November 2018
11 Reads

The Broad-Ranging Panorama of Systemic Autoinflammatory Disorders with Specific Focus on Acute Painful Symptoms and Hematologic Manifestations in Children.

Authors:
Donato Rigante

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018067. Epub 2018 Nov 1.

Institute of Pediatrics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal membranes, gastrointestinal tube, and other tissues, which recur with variable rhythmicity and display reactive amyloidosis as a potential long-term complication. Dysregulated inflammasome activity leading to overproduction of many proinflammatory cytokines, such as interleukin-1 (IL-1), and delayed shutdown of inflammation are considered crucial pathogenic keys in the vast majority of SAIDs. Progress of cellular biology has partially clarified the mechanisms behind monogenic SAIDs, such as familial Mediterranean fever, tumor necrosis factor receptor-associated periodic syndrome, cryopyrin-associated periodic syndrome, mevalonate kinase deficiency, hereditary pyogenic diseases, idiopathic granulomatous diseases and defects of the ubiquitin-proteasome pathway. Read More

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http://dx.doi.org/10.4084/MJHID.2018.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223578PMC
November 2018
4 Reads

Vitamin D levels in patients with recurrent aphthous stomatitis.

BMC Oral Health 2018 Nov 9;18(1):186. Epub 2018 Nov 9.

Department of Family Medicine, Hitit University Medical School, Çorum, Turkey.

Background: Lower serum vitamin D levels, a major public health problem worldwide, has been found to be associated with various infectious diseases, cancers, autoimmune and dermatological diseases. The serum levels of vitamin D in patients with recurrent aphthous stomatitis are not clear. We investigated the vitamin D levels in patients with recurrent aphthous stomatitis. Read More

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https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12903-018-0653-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230238PMC
November 2018
11 Reads

Incidence of indications for tonsillectomy and frequency of evidence-based surgery: a 12-year retrospective cohort study of primary care electronic records.

Br J Gen Pract 2019 Jan 5;69(678):e33-e41. Epub 2018 Nov 5.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: Neither the incidence of indications for childhood tonsillectomy nor the proportion of tonsillectomies that are evidence-based is known.

Aim: To determine the incidence of indications for tonsillectomy in UK children, and the proportion of tonsillectomies meeting evidence-based criteria.

Design And Setting: A retrospective cohort study of electronic medical records of children aged 0-15 years registered with 739 UK general practices contributing to a research database. Read More

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http://dx.doi.org/10.3399/bjgp18X699833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301361PMC
January 2019
2 Reads

New Functions of Classical Compounds against Orofacial Inflammatory Lesions.

Medicines (Basel) 2018 Nov 1;5(4). Epub 2018 Nov 1.

Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Anti-inflammatory agents have been widely used to ameliorate severe inflammatory symptoms of a number of diseases, and such therapeutics are particularly useful for diseases with intolerable pain without significant mortality. A typical example of this is a disease known as stomatitis; although stomatitis itself is not a life-threatening disease, it severely impairs the individual's quality of life, and thus a standard therapeutic strategy for it has already been established. The topical application of a bioactive agent is quite easy, and a strong anti-inflammatory agent can be used without significant adverse effects. Read More

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http://dx.doi.org/10.3390/medicines5040118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313344PMC
November 2018
14 Reads

[Aphthous mouth ulcers as an initial manifestation of sécukinumab-induced inflammatory bowel disease].

Ann Dermatol Venereol 2018 Nov 23;145(11):676-682. Epub 2018 Oct 23.

Université François-Rabelais, 37000 Tours, France; Service de dermatologie, CHU, hôpital Trousseau, 37044 Tours cedex, France; Équipe BIP, ISP 1282 INRA-Université de Tours, 37000 Tours, France. Electronic address:

Background: Secukinumab, a humanized monoclonal antibody targeting interleukin 17A, has been associated with the development of inflammatory bowel diseases. We report a case of a female patient developing recurrent oral ulcers prior to inflammatory bowel disease induced by secukinumab. The patient had developed similar oral ulcers 6 years earlier while on tocilizumab (targeting IL6R), suggesting an immunological link between the two episodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638183049
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http://dx.doi.org/10.1016/j.annder.2018.07.009DOI Listing
November 2018
9 Reads