4,058 results match your criteria Aphthous Stomatitis


Zinc supplementation for prevention and management of recurrent aphthous stomatitis: a systematic review.

J Trace Elem Med Biol 2021 Jun 12;68:126811. Epub 2021 Jun 12.

Department of Preventive and Biomedical Science, Faculty of Dentistry, University of Science and Technology, Sana'a, Yemen. Electronic address:

Background: Recurrent aphthous stomatitis (RAS) is a very common oral ulcerative disease with no definitive cure. Growing evidence suggests a significant association between zinc deficiency and RAS.

Objectives: To assess the efficacy of systemic zinc supplementations in the prevention and management of RAS. Read More

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Recent Advancements and Patents on Buccal Drug Delivery Systems: A Comprehensive Review.

Recent Pat Nanotechnol 2021 Jun 9. Epub 2021 Jun 9.

Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow, India.

The major requirement for a dosage form to be successful is its ability to penetrate the site of application and the bioavailability of the drug released from the dosage form. The buccal drug delivery is an influential route to deliver the drug into the body. Here in this context, various novel approaches that include lipoidal carriers like ethosomes, transferosomes, niosomes, etc. Read More

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Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Rare Etiology of Fever in Adults.

Cureus 2021 Apr 29;13(4):e14749. Epub 2021 Apr 29.

Internal Medicine, Hospital De Cascais Dr. José De Almeida, Lisbon, PRT.

We report the case of a 28-year-old male, with a past history of recurrent pharyngitis and tonsillectomy, who presented to the emergency department with fever, pharyngitis, and cervical adenitis. Inflammatory markers were elevated and the patient was initially started on ceftriaxone with remission after four days. However, the symptoms recurred three weeks later and an autoinflammatory disease was suspected. Read More

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Combination of Levamisole with Prednisone in Treating Recurrent Major Aphthous Ulcer in a Young Boy: A Case Report.

Clin Pract 2021 May 6;11(2):250-256. Epub 2021 May 6.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, P. O. Box 10219, Riyadh 11433, Saudi Arabia.

Recurrent aphthous stomatitis (RAS) is an oral condition characterized by painful oral ulcerations. While the clinical features of this disease are easily defined, the etiology remains unclear. Thus, existing treatments are still unsatisfactory in reducing the severity, healing, and recurrence rate; however, there is no permanent and definitive treatment. Read More

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Syndrome of Undifferentiated Recurrent Fever (SURF): An Emerging Group of Autoinflammatory Recurrent Fevers.

J Clin Med 2021 May 3;10(9). Epub 2021 May 3.

Center for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.

Syndrome of undifferentiated recurrent fever (SURF) is a heterogeneous group of autoinflammatory diseases (AID) characterized by self-limiting episodes of systemic inflammation without a confirmed molecular diagnosis, not fulfilling the criteria for periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. In this review, we focused on the studies enrolling patients suspected of AID and genotyped them with next generation sequencing technologies in order to describe the clinical manifestations and treatment response of published cohorts of patients with SURF. We also propose a preliminary set of indications for the clinical suspicion of SURF that could help in everyday clinical practice. Read More

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Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study.

J Int Med Res 2021 May;49(5):3000605211017724

Department of Oral Medicine, 144984Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Objective: Recurrent aphthous stomatitis (RAS), a common oral mucosal disorder characterized by chronic, inflammatory, and ovoid ulcers, has a complex etiology. The purpose of the study was to investigate the specific dietary factors influencing the prevalence of RAS.

Methods: A total of 754 participants aged 18 to 59 years were enrolled in this descriptive cross-sectional study. Read More

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Are Oral Mucosal Changes a Sign of COVID-19? A Cross-Sectional Study at a Field Hospital.

Actas Dermosifiliogr 2021 May 12. Epub 2021 May 12.

Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain.

Background: Coronavirus disease 19 (COVID-19) has many manifestations, including respiratory, thrombotic, neurologic, digestive, and cutaneous ones. Cutaneous manifestations have been classified into 5 clinical patterns: acro-ischemic (pseudo-chilblain), vesicular, urticarial, maculopapular, and livedoid. Oral manifestations have also been reported, but much less frequently. Read More

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PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome: an overview of genetic background.

Clin Rheumatol 2021 May 20. Epub 2021 May 20.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, 14194, Tehran, Iran.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is an autoinflammatory disorder with an uncertain origin. PFAPA manifestations occur in the form of regular attacks accompanied by a rise in inflammatory markers. Regarding the family clustering of PFAPA and its similarities with other autoinflammatory disorders such as familial Mediterranean fever, a genetic basis is suggested for the disease. Read More

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Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge.

Clin Exp Immunol 2021 May 18. Epub 2021 May 18.

Section of Clinical and Laboratory Immunology, Division of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Lymphadenopathies can be part of the clinical spectrum of several primary immunodeficiencies, including diseases with immune dysregulation and autoinflammatory disorders, as the clinical expression of benign polyclonal lymphoproliferation, granulomatous disease or lymphoid malignancy. Lymphadenopathy poses a significant diagnostic dilemma when it represents the first sign of a disorder of the immune system, leading to a consequently delayed diagnosis. Additionally, the finding of lymphadenopathy in a patient with diagnosed immunodeficiency raises the question of the differential diagnosis between benign lymphoproliferation and malignancies. Read More

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Medication-related osteonecrosis of the jaw (MRONJ) and eNOS Polymorphisms in multiple myeloma patients: a single center experience.

BMC Oral Health 2021 05 18;21(1):272. Epub 2021 May 18.

Department of Hematology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.

Background: Multiple myeloma (MM) constitutes approximately 10% of hematological malignancies. Bisphosphonates have established themselves in solid organ metastasis and multiple myeloma lytic bone lesions by inhibiting osteoclast activation. Medication-related osteonecrosis of the jaw (MRONJ) emerges as an important complication. Read More

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The Effect of Carbon Dioxide Laser on Aphthous stomatitis Treatment: A Double-Blind Randomized Clinical Trial.

J Lasers Med Sci 2020 30;11(Suppl 1):S67-S72. Epub 2020 Dec 30.

School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

This randomized clinical trial was designed to investigate the effect of carbon dioxide laser on the treatment of minor recurrent aphthous stomatitis (miRAS) as a painful and common oral ulcer. Fifteen patients with miRAS entered into this study after compliance with the inclusion and exclusion criteria. The patients were assigned to three groups of pulsed CO laser, continuous CO laser, and control. Read More

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December 2020

Are Oral Mucosal Changes a Sign of COVID-19? A Cross-Sectional Study at a Field Hospital.

Actas Dermosifiliogr (Engl Ed) 2021 May 12. Epub 2021 May 12.

Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain.

Background: Coronavirus disease 19 (COVID-19) has many manifestations, including respiratory, thrombotic, neurologic, digestive, and cutaneous ones. Cutaneous manifestations have been classified into 5 clinical patterns: acro-ischemic (pseudo-chilblain), vesicular, urticarial, maculopapular, and livedoid. Oral manifestations have also been reported, but much less frequently. Read More

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Differential cytokine profiles in pediatric patients with PFAPA syndrome and recurrent tonsillitis.

J Med Invest 2021 ;68(1.2):38-41

Department of Otolaryngology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan.

Objective : An attempt was made to identify characteristic cytokine profiles to distinguish periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPAS) from recurrent tonsillitis, of which clinical manifestations are similar to those of PFAPAS in children. Methods : Serum concentrations of IL-6, IL-4 and IFN-γ were measured during febrile episodes in pediatric patients. Results : The levels of IL-6 during febrile episodes were markedly increased above the upper limit of normal ranges in patients with both PFAPAS and recurrent tonsillitis, but there were no significant differences between groups. Read More

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January 2021

Self-case report of oral and skin lesions associated with positivity of COVID-19.

J Cosmet Dermatol 2021 May 15. Epub 2021 May 15.

Department of Prosthetic Dentistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

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Comprehensive management of major aphthous ulcer.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Oral Medicine and Radiology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

Recurrent aphthous ulcers are the most prevalent oral mucosal disease, but the subset major aphthous ulcer is a less frequent type. These ulcers are refractory, may persist for several weeks to months, and interfere with the normal state of health. The aetiology is multifactorial and so is the treatment. Read More

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Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation.

Pediatr Rheumatol Online J 2021 May 10;19(1):70. Epub 2021 May 10.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.

Background: Recurrent aphthous stomatitis with systemic signs of inflammation can be encountered in inflammatory bowel disease, Behçet's disease (BD), Systemic Lupus Erythematosus (SLE). In addition, it has been proposed that cases with very early onset in childhood can be underpinned by rare monogenic defects of immunity, which may require targeted treatments. Thus, subjects with early onset recurrent aphthous stomatitis receiving a clinical diagnosis of BD-like or SLE-like disease may deserve a further diagnostic workout, including immunologic and genetic investigations. Read More

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Clinical Features of Female Taiwanese Carriers with X-linked Chronic Granulomatous Disease from 2004 to 2019.

J Clin Immunol 2021 May 8. Epub 2021 May 8.

Division of Infection, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Purpose: Female carriers with X-linked chronic granulomatous disease (XL-CGD) who have < 10% reactive oxygen species (ROS) production due to profound X-chromosome inactivation (XCI or lyonization) are more susceptible to infections. We assessed ROS production in Taiwanese female carriers with XL-CGD to investigate whether the level of ROS correlated to their clinical features of infection, autoimmunity, and autoinflammation.

Methods: Clinical course, ROS production, flavocytochrome b558 (Cyto b558) expression, and genetic analysis in carriers were investigated after identifying their index cases between 2004 and 2019. Read More

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Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert's Syndrome.

Case Rep Dent 2021 16;2021:6648729. Epub 2021 Apr 16.

Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University, Str. Koryun 2, Yerevan 0025, Armenia.

Recurrent aphthous stomatitis is an ulcerative disease of the oral cavity and can occur in isolation or as a manifestation of many systemic diseases. It is a quite common entity and may hence often be overlooked as an isolated lesion. Gilbert's syndrome is a genetic disorder where a deficiency of an enzyme associated with the conjugation of bilirubin results in unconjugated hyperbilirubinemia. Read More

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The Impact of DNA Methylation on IL6 mRNA Levels in Hematinic Deficiency and Atopy-Associated Recurrent Aphthous Stomatitis Patients.

Int J Dent 2021 12;2021:5560695. Epub 2021 Apr 12.

Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.

Objective: To investigate the DNA methylation using pyrosequencing and its effects on the upregulation of IL6 mRNA in patients with recurrent aphthous stomatitis (RAS) in connection with hematinic deficiency and atopy. . This cross-sectional study was conducted at Dr. Read More

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Risk of cancer in patients with recurrent aphthous stomatitis in Korea: A nationwide population-based study.

Medicine (Baltimore) 2021 Apr;100(16):e25628

Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul.

Abstract: The relationship between recurrent aphthous stomatitis (RAS), a common mucosal lesion, and cancer has not been demonstrated. This study investigated the risk for developing cancer in patients with RAS, based on data from Korea's National Health Insurance Sharing Service (NHISS). Nationwide population-based cohort data from 2005 to 2009 provided by the NHISS was used. Read More

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From Simple Mouth Cavities to Complex Oral Mucosal Disorders-Curcuminoids as a Promising Therapeutic Approach.

ACS Pharmacol Transl Sci 2021 Apr 17;4(2):647-665. Epub 2021 Mar 17.

Cancer Biology Laboratory and DBT-AIST International Center for Translational and Environmental Research (DAICENTER), Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India.

Oral diseases are among the most common encountered health issues worldwide, which are usually associated with anomalies of the oral cavity, jaws, and salivary glands. Despite the availability of numerous treatment modalities for oral disorders, a limited clinical response has been observed because of the inefficacy of the drugs and countless adverse side effects. Therefore, the development of safe, efficacious, and wide-spectrum therapeutics is imperative in the battle against oral diseases. Read More

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Recurrent Aphthous Stomatitis Improved after Eradication Therapy for .

Case Rep Gastrointest Med 2021 30;2021:5543838. Epub 2021 Mar 30.

Gastroenterology Department, Loma Linda University Medical Center, Loma Linda, CA, USA.

(. ) is a Gram-negative bacterium that colonizes gastric mucosa and is often transmitted through direct contact with saliva, contaminated food or water, and vomit. The majority of the infected individuals remain asymptomatic for a long period. Read More

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TuberOus SClerosis registry to increAse disease awareness (TOSCA) Post-Authorisation Safety Study of Everolimus in Patients With Tuberous Sclerosis Complex.

Front Neurol 2021 23;12:630378. Epub 2021 Mar 23.

Pediatric Neurology Unit, Department of Paediatrics, UZ Brussel VUB, Brussels, Belgium.

This non-interventional post-authorisation safety study (PASS) assessed the long-term safety of everolimus in patients with tuberous sclerosis complex (TSC) who participated in the TuberOus SClerosis registry to increase disease Awareness (TOSCA) clinical study and received everolimus for the licensed indications in the European Union. The rate of adverse events (AEs), AEs that led to dose adjustments or treatment discontinuation, AEs of potential clinical interest, treatment-related AEs (TRAEs), serious AEs (SAEs), and deaths were documented. One hundred seventy-nine patients were included in the first 5 years of observation; 118 of 179 patients had an AE of any grade, with the most common AEs being stomatitis (7. Read More

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Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study.

PLoS One 2021 8;16(4):e0249862. Epub 2021 Apr 8.

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Aim: To evaluate the effectiveness of non-aromatic very rich in steranes (NAVS) naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Null hypothesis was that there would be no difference between NAVS and topical steroids in the treatment of OLP and RAS.

Methods: The study consisted of two sub-trials conducted as randomized, double-blind controlled studies: first included OLP patients and second patients with RAS. Read More

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Pharmacokinetic Study of Safrole and Methyl Eugenol after Oral Administration of the Essential Oil Extracts of in Rats by GC-MS.

Biomed Res Int 2021 19;2021:6699033. Epub 2021 Mar 19.

State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

is a traditional medicine and has been widely used as remedies for inflammatory diseases, toothache, headache, local anesthesia, and aphthous stomatitis in China, Japan, and Korea. Our previous research found that safrole and methyl eugenol were vital compounds that contribute to distinguish the different species and raw and its processed products apart. The pharmacokinetics of safrole and methyl eugenol after oral administration of extract has not been reported yet. Read More

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Spectrum of Systemic Auto-Inflammatory Diseases in India: A Multi-Centric Experience.

Front Immunol 2021 19;12:630691. Epub 2021 Mar 19.

Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Systemic autoinflammatory diseases (SAID) are rare inherited disorders involving genes regulating innate immune signaling and are characterized by periodic or chronic multi-systemic inflammation. To describe spectrum of clinical, immunological, molecular features, and outcomes of patients with SAID in India. Request to share data was sent to multiple centers in India that are involved in care and management of patients with Inborn Errors of Immunity. Read More

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The Temporal Relationships and Associations between Cutaneous Manifestations and Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study.

J Clin Med 2021 Mar 22;10(6). Epub 2021 Mar 22.

Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan.

The temporal relationships between inflammatory bowel disease (IBD)-associated cutaneous manifestations and IBD remain uncertain, with existing evidence mostly from separate cross-sectional studies. We sought to determine the risks of IBD-related dermatologic diseases before and after the diagnosis of IBD. We identified 2847 cases of IBD and 14,235 matched controls from the Taiwan National Health Insurance Research Database between 2003 and 2014. Read More

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Salivary irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients.

Eur Rev Med Pharmacol Sci 2021 Mar;25(5):2252-2259

Department of Nutrition and Dietetics, Ordu Unıversıty, Ordu, Turkey.

Objective: Recurrent Aphthous Stomatitis (RAS) is the most common inflammatory condition of the oral mucosa characterised by recurrent onset of single or multiple painful ulcers mainly affecting the nonkeratinized oral mucosa. RAS mostly occurs in healthy individuals with no associated systemic diseases. Irisin is a newly identified adipomyokine and research has revealed that it has anti-inflammatory effects. Read More

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Serum levels of vitamin D in patients with recurrent aphthous stomatitis.

Dent Med Probl 2021 Jan-Mar;58(1):27-30

Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Iran.

Background: Recurrent aphthous stomatitis (RAS) is one of the most common recurrent ulcerations in the oral mucosa, the etiology of which has not been elucidated; the immune system dysfunction may play an important role in the pathogenesis of RAS. The anti-inflammatory and regulatory role of vitamin D in the functioning of the immune system is well-documented.

Objectives: This study aimed to evaluate and compare the serum levels of vitamin D between patients with RAS and healthy controls. Read More

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Altered oral microbiota composition associated with recurrent aphthous stomatitis in young females.

Medicine (Baltimore) 2021 Mar;100(10):e24742

Institute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.

Abstract: Oral microbiota has been implicated in pathogenesis of recurrent aphthous stomatitis (RAS), which is a common mucosal disorder with unclear etiology. This study has explored the association between oral microbiota disorder and RAS in high-risk young female population.Forty-five young females were enrolled, including 24 RAS patients and 21 healthy individuals. Read More

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