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    The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints.
    BMC Oral Health 2017 Mar 21;17(1):67. Epub 2017 Mar 21.
    Faculty of Engineering, Department of Genetics and Bioengineering, Yeditepe University, İstanbul, Turkey.
    Background: The oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. Read More

    Contact Allergy to (Ingredients of) Toothpastes.
    Dermatitis 2017 Mar/Apr;28(2):95-114
    From acdegroot publishing, Wapserveen, The Netherlands.
    The literature on contact allergy to (ingredients of) toothpastes is critically reviewed. We have found 47 case reports, small case series (n = 2-5) and citations published between 1900 and 2016 describing more than 60 patients allergic to toothpastes, and in addition 3 larger case series and many descriptions of toothpaste allergy among selected groups of patients. Allergic reactions usually manifest as cheilitis with or without dermatitis around the mouth, less frequently by oral symptoms. Read More

    Clinical Evaluation of High and Low-Level Laser Treatment (CO2vsInGaAlP Diode Laser) for Recurrent Aphthous Stomatitis.
    J Dent (Shiraz) 2017 Mar;18(1):17-23
    Dept. of Oral Medicine, Dental School, Azad University, Tehran, Iran.
    Statement Of The Problem: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral cavity. Due to its multifactorial nature, there is no definitive treatment for RAS. Laser therapy is one of the suggested treatments to reduce patient's discomfort. Read More

    Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome.
    Rheumatol Int 2017 Mar 7. Epub 2017 Mar 7.
    Pediatric Rheumatology, Goryeb Children's Hospital, Atlantic Health System, Morristown Medical Center/Overlook Hospital, Morristown, NJ, USA.
    To assess the practice patterns of pediatric rheumatology and infectious diseases subspecialists in the diagnosis and treatment of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. An online survey assessing diagnostic and treatment approaches was sent to 424 members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) and 980 members of the Pediatric Infectious Disease Society (PIDS). 277 physicians (123 from CARRA and 154 from PIDS representing 21% of the total membership) completed the survey. Read More

    Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis.
    Med Clin (Barc) 2017 Feb 18. Epub 2017 Feb 18.
    Centro Odontológico M'fedal Afailal Bab Okla, Tetuán, Marruecos.
    Background And Objective: Despite the high prevalence of recurrent aphthous stomatitis (RAS), its etiology is not yet completely clear and there is no completely remedial treatment available at present. The objective of this study was to evaluate the clinical efficacy and safety of 4 treatments (silver nitrate, propolis, rhubarb and walnut) for RAS.

    Patients And Method: A randomized clinical trial was conducted with 125 patients with minor aphthae, including 25 patients per group: cauterization with silver nitrate, propolis, rhubarb extract, walnut extract and placebo. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    Is colchicine more effective to prevent PFAPA episodes in MEFV variants ?
    Pediatr Int 2017 Feb 16. Epub 2017 Feb 16.
    Pediarics, Uludag University Faculty of Medicine, Division of Pediatric Immunology. Uludag University Faculty of Medicine, Görükle- Bursa, 16059, Turkey.
    Background: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most frequent repetitive fever syndrome in childhood. It is characterized with fever episodes lasting for about three to six days, once every three to eight weeks.

    Methods: Clinical and laboratory data of patients with PFAPA syndrome between January 2010 and December 2014 followed up at a tertiary pediatric care hospital were reviewed. Read More

    Clinacanthus nutans: a review on ethnomedicinal uses, chemical constituents and pharmacological properties.
    Pharm Biol 2017 Dec;55(1):1093-1113
    a Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link , Gadong , Brunei Darussalam.
    Context: Medicinal plants have attracted global attention for their hidden therapeutic potential. Clinacanthus nutans (Burm.f) Lindau (Acanthaceae) (CN) is endemic in Southeast Asia. Read More

    Exploring the Molecular Mechanism and Biomarker of Recurrent Aphthous Stomatitis Based on Gene Expression Microarray.
    Clin Lab 2017 Feb;63(2):249-253
    Background: Recurrent aphthous stomatitis (RAS) is one of the most common chronic oral diseases with morbidity ranging from 5% to 20%. The pathogenesis is still not fully understood though immune dysregulation and local trauma have been implicated and the curative effect that can be achieved through current therapy is mainly to alleviate the pain. So, the understanding of its molecular mechanisms can allow the prevention and treatment of RAS at the molecular level. Read More

    An Up-to-date Approach to a Patient with a Suspected Autoinflammatory Disease.
    Rambam Maimonides Med J 2017 Jan 30;8(1). Epub 2017 Jan 30.
    Rheumatology Unit, Sheba Medical Center, Tel HaShomer Hospital, Tel Aviv, Israel.
    Autoinflammatory diseases (AID) are characterized by seemingly unprovoked self-limited attacks of fever and systemic inflammation potentially leading to amyloidosis. Familial Mediterranean fever (FMF) is the most common AID and therefore the most studied. Besides FMF, the other main hereditary AID are tumor necrosis factor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency (MKD), and cryopyrin-associated periodic fever syndrome (CAPS). Read More

    An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial.
    Med Oral Patol Oral Cir Bucal 2017 Mar 1;22(2):e159-e166. Epub 2017 Mar 1.
    Istanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, 34093 Istanbul, Turkey,
    Background: Triester glycerol oxide gel (Protefix® Queisser Pharma, Germany) is a new topical agent that has the property of adherence to the oral mucosa by forming a lipid film which protects against mechanical trauma and may help to reduce oral tissue moisture loss and inflammation. The aim of this clinical trial was to determine the efficacy of a topical TGO gel and to also compare it with triamcinolone acetonide pomade in the treatment of minor recurrent aphthous stomatitis.

    Material And Methods: This study was a randomized, double-blind, placebo-controlled clinical trial and 180 patients with the complaint of minor aphthous ulcers were enrolled in this study. Read More

    Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.
    J Immunol 2017 Mar 30;198(5):2063-2069. Epub 2017 Jan 30.
    Pediatric Rheumatology Unit of Western Switzerland, Pediatric Department, University Hospital Center Vaudois, University of Lausanne, 1011 Lausanne, Switzerland;
    Periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is a relatively common autoinflammatory condition that primarily affects children. Although tendencies were reported for this syndrome, genetic variations influencing risk and disease progression are poorly understood. In this study, we performed next-generation sequencing for 82 unrelated PFAPA patients and identified a frameshift variant in the CARD8 gene (CARD8-FS). Read More

    Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review.
    Scientifica (Cairo) 2016 18;2016:9062430. Epub 2016 Dec 18.
    The Hospital of Anhui Province, Hefei 230001, China.
    Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. Read More

    Efficacy and safety of Chinese patent medicines in the treatment of recurrent aphthous stomatitis: A systematic review.
    J Am Dent Assoc 2017 Jan;148(1):17-25
    Background: Recurrent aphthous stomatitis (RAS) is the most common chronic oral mucosal condition of the oral cavity. Investigators in clinical trials have evaluated the effectiveness of Chinese patent medicines in the treatment of RAS. However, the results are conflicting rather than conclusive. Read More

    Enzymatic antioxidants status in patients with recurrent aphthous stomatitis.
    J Oral Pathol Med 2017 Jan 5. Epub 2017 Jan 5.
    Department of Stomatology, Bethune International Peace Hospital, Shijiazhuang, China.
    Background: Oxidative stress (OS) has been thought to play a main role in the etiopathogenesis of recurrent aphthous stomatitis (RAS), which is one of the most common oral mucosal diseases characterized by recurrent and painful oral ulcers. The aim of this investigation was to evaluate the enzymatic antioxidants status in patients with RAS in the active stage and remission stage.

    Methods: Ninety-seven patients with idiopathic minor RAS and 102 race-, age- and gender-matched healthy individuals were recruited. Read More

    Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing.
    Int J Dermatol 2017 Mar 30;56(3):302-306. Epub 2016 Dec 30.
    Hacettepe University, School of Medicine, Department of Dermatology, Ankara, Turkey.
    Background: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS.

    Methods: This prospective study included 24 patients with RAS and 22 healthy controls. Read More

    Status of Neutrophils, Lymphocytes and Platelets in Patients with Recurrent Aphthous Stomatitis: A Retrospective Study.
    Iran J Otorhinolaryngol 2016 Nov;28(89):421-424
    Department of Otorhinolaryngology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
    Introduction: The aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in patients with recurrent aphthous stomatitis (RAS).

    Materials And Methods: Eighty patients who were diagnosed with RAS between January 2014 and January 2016 were included in this study. Eighty age- and gender-matched healthy subjects were also enrolled as a control group. Read More

    Familial Mediterranean fever with P369S/R408Q exon3 variant in pyrin presenting as symptoms of PFAPA.
    Mod Rheumatol 2017 Mar;27(2):356-359
    c Department of Infection and Host Defense, Graduate School of Medicine , Shinshu University , Matsumoto , Japan.
    Familial Mediterranean fever (FMF) can be classified into typical and incomplete/atypical types. Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome-like symptoms have been found in atypical type carrying P369S-R408Q mutations in the responsible gene MEFV. A 28-year-old female with recurrent fever and her young sisters and mother, all of whom had tonsillectomy for tonsillitis, carried heterozygous alterations involving E148Q/P369S/R408Q. Read More

    Mumps, measles and rubella vaccination in children with PFAPA syndrome.
    Vaccine 2016 Nov 27;34(48):5903-5906. Epub 2016 Oct 27.
    Department and Clinic of Paediatric Infectious Diseases, Wroc?aw Medical University, 2-2A Cha?ubi?skiego, 50-368 Wroc?aw, Poland. Electronic address:
    There is no published data regarding immunologic response to vaccinations in children with PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis). The aim of this study was to evaluate mumps, measles and rubella immunity in children with PFAPA. 31 children with PFAPA syndrome and 22 healthy children (control group - CG) were recruited to the study. Read More

    Different modalities for treatment of recurrent aphthous stomatitis. A Randomized clinical trial.
    J Clin Exp Dent 2016 Dec 1;8(5):e517-e522. Epub 2016 Dec 1.
    Professor. Department of Pharmacognosy, National Research Centre, Giza, Egypt.
    Background: The underlying etiology of recurrent aphthous stomatitis (RAS) is unclear and treatment aims to provide symptomatic and faster relief. This study compared the efficacy of diode laser, a herbal combination of Acacia nilotica and Licorice (A and L) and Amlexanox in the management of RAS.

    Material And Methods: Sixty patients with minor aphthae were selected and randomly divided into four groups of 15 each. Read More

    Clinical phenotype of recurrent aphthous stomatitis and interleukin-1β genotype in a Polish cohort of patients.
    J Oral Pathol Med 2016 Dec 9. Epub 2016 Dec 9.
    Department of Oral Mucosa Diseases, University of Medical Sciences, Poznań, Poland.
    Background: The aim of this study was to evaluate the relation between a clinical profile and the interleukin-1β (IL-1β) genotype in a Polish cohort of patients with RAS.

    Methods: One hundred and four patients with RAS were enrolled in the study and all were subject to an oral examination. The severity of RAS was assessed according to the clinical type of the disease, the number of lesions per flare-up and the length of intervals between the episodes. Read More

    HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis.
    Iran J Allergy Asthma Immunol 2016 Aug;15(4):289-295
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Universal Scientific Education and Research Network (USERN), Tehran, Iran.
    Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. Read More

    Lack of Association between Interleukin-12 Gene Polymorphisms and Recurrent Aphthous Stomatitis.
    Avicenna J Med Biotechnol 2016 Oct-Dec;8(4):200-201
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA.

    Associations among oral health-related quality of life, subjective symptoms, clinical status, and self-rated oral health in Japanese university students: a cross-sectional study.
    BMC Oral Health 2016 Nov 30;16(1):127. Epub 2016 Nov 30.
    Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: The present study aimed to elucidate the associations among self-rated oral health, clinical oral health status, oral health behaviors, subjective oral symptoms, and oral health-related quality of life (OHRQoL) in a group of Japanese university students.

    Methods: Of 2051 participants, 2027 (98.83%) students received an optional oral examination and answered a questionnaire including items regarding age, sex, self-rated oral health, oral health behaviors, subjective oral symptoms, and OHRQoL [The Oral Health Impact Profile (OHIP)-14]. Read More

    On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa.
    Oral Dis 2017 Apr 13;23(3):347-352. Epub 2017 Jan 13.
    Biomodels, LLC, Watertown, MA, USA.
    Objective: mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor-associated stomatitis (mIAS) a common, significant, dose-limiting toxicity, with aphthous-like lesions. Our objective was to assess the utility of a new organotypic model in defining mIAS' pathogenesis.

    Materials And Methods: The effect of everolimus on organotypic human oral mucosa was studied. Read More

    Is Optimal Management of Recurrent Aphthous Stomatitis Possible? A Reality Check.
    J Clin Diagn Res 2016 Oct 1;10(10):ZE08-ZE13. Epub 2016 Oct 1.
    Professor and Head of Department, Department of Oral Medicine and Radiology, The Oxford Dental College , Bengaluru, Karnataka, India .
    Recurrent Aphthous Stomatitis (RAS) is a condition in which aphthous ulcers repeatedly occur in the oral cavity. It is prevalent in developed countries, occurring in all ages, geographic regions and races and about 80% of people have one episode of oral aphthous ulcers before the age of 30 years. With no laboratory procedures to confirm the diagnosis, treatment is mainly empirical in nature and focuses on short-term symptomatic management. Read More

    Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis.
    Arch Oral Biol 2017 Feb 5;74:51-54. Epub 2016 Nov 5.
    Gaziosmanpasa University, Faculty of Dentistry, Department of Prosthodontics, Tokat, Turkey.
    Objectives: Recurrent aphthous stomatitis (RAS) is a common painful disorder affecting oral health, mucosa and overall quality of life. The etiopathogenesis of RAS remains unclear. RAS shows a large genetic diversity among the patients. Read More

    Low-level Laser Therapy: A Review of Its Applications in the Management of Oral Mucosal Disorders.
    Altern Ther Health Med 2016 Nov;22(6):24-31
    Due to its analgesic, anti-inflammatory, and biostimulating effects, low-level laser therapy (LLLT) has been widely used for oral disorders, such as oral lichen planus (OLP), xerostomia, recurrent aphthous stomatitis (RAS), herpes labialis, burning mouth syndrome (BMS), and oral mucositis (OM). The research team for the present study has reviewed the literature on the subject, with an emphasis on the applicability of LLLT in general and of its various clinical protocols for the management of those oral disorders. In lesions such as the ones occurring in OM, RAS, herpes labialis, and OLP, the course of wound healing and the pain have been shown to decrease, with a few, or most often, no adverse side effects. Read More

    Marshall syndrome in a young child, a reality: Case report.
    Medicine (Baltimore) 2016 Nov;95(44):e5065
    a"Sfanta Maria" Clinical Emergency Hospital for Childrenb"Grigore T. Popa" University of Medicine and Pharmacy, IasicEndocrinology Department of Clinical County Emergency Hospital, Cluj-NapocadENT Department of Arcadia Hospital, Iasi, Romania.
    Background: Recurrent fever syndrome, known as the Marshall syndrome (MS), is a clinical entity that includes several clinical features, such as: fever (39-40°C) that occurs repeatedly at variable intervals (3-8 weeks) and in episodes of 3 to 6 days, cervical adenopathy, pharyngitis, and aphthous stomatitis. The diagnosis of MS is one of exclusions; laboratory data is nonspecific and no abnormalities correlated with MS have been detected thus far.

    Methods: The authors report the case of a 2-year-old girl admitted to a tertiary pediatric center for repeated episodes of fever with aphthous stomatitis and laterocervical adenopathy. Read More

    Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis.
    J Formos Med Assoc 2016 Dec 7;115(12):1061-1068. Epub 2016 Nov 7.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG-/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG-/RAS patients, respectively.

    Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Read More

    [Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].
    Hautarzt 2016 Dec;67(12):940-947
    Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.
    Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

    Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

    Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

    Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients.
    J Formos Med Assoc 2017 Feb 5;116(2):99-106. Epub 2016 Nov 5.
    School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs-/RAS) patients.

    Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs-/RAS patients, and 342 healthy control subjects. Read More

    Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients with anti-thyroid antibody positivity.
    J Formos Med Assoc 2017 Mar 5;116(3):145-152. Epub 2016 Nov 5.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA-/TGA/TMA/RAS patients).

    Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA-/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs-/RAS patients), and 342 healthy control subjects. Read More

    Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease: Prevalence, Presentation and anti-TNF Treatment.
    J Pediatr Gastroenterol Nutr 2016 Oct 31. Epub 2016 Oct 31.
    *Division of Gastroenterology and Hepatology, University Hospital Zurich, Switzerland †Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Switzerland ‡Praxis Römerhof, Olten, Switzerland §Institute for Social and Preventive Medicine, University of Bern, Switzerland ||Division of Gastroenterology, The National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia ¶Division of Gastroenterology and Nutrition and Children's Research Center, University Children's Hospital Zurich, Switzerland #Department of Pediatrics, Kantonsspital Winterthur, Switzerland **Division of Gastroenterology and Hepatology, Kinderspital St. Gallen, Switzerland ††Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Hospital Lausanne - CHUV, Switzerland ‡‡Department of Pediatrics, University Hospital Geneva - HCUG, Switzerland §§Division of Gastroenterology and Hepatology, University Children's Hospital Bern, Switzerland ||||Division of Gastroenterology and Nutrition, University Children's Hospital Basel - UKBB, Switzerland ¶¶Department of Pediatrics, Kantonsspital Luzern - LUKS, Switzerland ##Private Practice, Pediatric Unit, Clinique des Grangettes, Geneva, Switzerland ***Private Practice, Onex, Switzerland †††Division of Gastroenterology and Hepatology, University Hospital Basel, Switzerland ‡‡‡Department of Pediatrics, Hopital Cantonal de Fribourg, Switzerland §§§Division of Gastroenterology and Hepatology, University Hospital Lausanne - CHUV, Switzerland.
    Background: There is a paucity of data on extraintestinal manifestations (EIM) and their treatment in pediatric patients with inflammatory bowel disease (IBD).

    Methods: Since 2008, the Pediatric Swiss IBD Cohort Study has collected data on the pediatric IBD population in Switzerland. Data on 329 patients were analyzed retrospectively. Read More

    Antigastric parietal cell and antithyroid autoantibodies in patients with recurrent aphthous stomatitis.
    J Formos Med Assoc 2017 Jan 25;116(1):4-9. Epub 2016 Oct 25.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Anti-gastric parietal cell antibody (GPCA), anti-thyroglobulin antibody (TGA), and anti-thyroid microsomal antibody (TMA) have not yet been reported in patients with recurrent aphthous stomatitis (RAS). This study mainly assessed the frequencies of the presence of serum GPCA, TGA, and TMA in different types of RAS patients.

    Methods: Serum GPCA, TGA, and TMA levels were measured in 355 RAS patients of different subtypes and in 355 age- and sex-matched healthy control individuals. Read More

    Demographic, clinical and therapeutic findings in a monocentric cohort of adult patients with suspected PFAPA syndrome.
    Clin Exp Rheumatol 2016 Sep-Oct;34(6 Suppl 102):77-81. Epub 2016 Oct 25.
    Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.
    Objectives: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenopathy (PFAPA) syndrome is a non-Mendelian autoinflammatory disorder until now considered to be specifically limited to paediatric age. Recently, an increasing number of reports seems to suggest that PFAPA syndrome, diagnosed by the Marshall criteria revised by Thomas et al., can also affect adults. Read More

    Design, Formulation and Evaluation of an Oral Gel from Punica Granatum Flower Extract for the Treatment of Recurrent Aphthous Stomatitis.
    Adv Pharm Bull 2016 Sep 25;6(3):391-398. Epub 2016 Sep 25.
    Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Purpose: Recurrent aphthous stomatitis is a disease with unknown etiology that's mostly treated symptomatically and has no definite cure. Pomegranate (Punica granatum) flowers have been used as medicinal herb that due to its antimicrobial, antioxidant, anti-inflammatory, analgesic and healing effects, has been useful in treatment of oral aphthous. Therefore, we decided to formulate a mucoadhesive gel with pomegranate flower extract to reduce the need for corticosteroid therapy in patients. Read More

    Efficacy of alum for treatment of recurrent aphthous stomatitis.
    Caspian J Intern Med 2016 ;7(3):201-205
    Faculty of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran.
    Background: Recurrent aphthous stomatitis (RAS) is the most common painful ulcers of oral mucosal which can cause many sufferings. Treatment of RAS often includes administration of corticosteroids, analgesics and regulators of the immune system. However, considering the side effects of these medications, even their topical application must be done with caution. Read More

    The relationship between recurrent aphthous stomatitis, and periodontal disease and Helicobacter Pylori infection.
    Clin Oral Investig 2016 Nov 6;20(8):2055-2060. Epub 2016 Jan 6.
    Faculty of Dentistry, Department of Periodontology, Hacettepe University, Ankara, Turkey.
    Objective: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease with unknown etiology. This cross-sectional study aimed to test the hypothesis that Helicobacter pylori and periodontal disease might play an etiological role in RAS.

    Methods: Dental plaque samples obtained from 38 patients with RAS and 43 healthy individuals via periodontal examinations were examined for H. Read More

    Management of recurrent aphthous ulcers using low-level lasers: A systematic review.
    Medicina (Kaunas) 2016 15;52(5):263-268. Epub 2016 Sep 15.
    Restorative Dentistry Department, College of Dentistry, Taibah University, Madinah Munawarrah, Saudi Arabia. Electronic address:
    Background And Objective: The exact etiology of recurrent aphthous ulcers (RAS) is unknown. The management of RAS is not always straightforward. The aim of this review is to critically analyze and summarize the clinical literature focusing on the management of aphthous ulcers using low-level lasers. Read More

    Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers.
    J Clin Exp Dent 2016 Oct 1;8(4):e368-e372. Epub 2016 Oct 1.
    Postgraduate Student of Endodontics. School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
    Background: Recurrent aphthous stomatitis (RAS) is a common condition that affects approximately 20% of the general population. The ulcers can interfere with speech and eating and cause significant pain and discomfort. This study aimed to evaluate the efficacy of Amlexanox and Adcortyl in the treatment of aphthous ulcers. Read More

    Myrtus communis L. and its application in treatment of Recurrent Aphthous Stomatitis.
    J Ethnopharmacol 2016 Dec 30;193:481-489. Epub 2016 Sep 30.
    Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran. Electronic address:
    Ethnopharmacological Relevance: In Iranian Traditional Medicine, M. communis is a famous plant in treatment of oral ulcers and "Gholaa"- the ancient name of aphthous.

    Objective: The aim of this review is to create a bridge between the traditional claims about the application of M. Read More

    Long-Term Outcome of Classic and Incomplete PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome after Tonsillectomy.
    J Pediatr 2016 Dec 28;179:172-177.e1. Epub 2016 Sep 28.
    PEDEGO Research Unit, Department of Pediatrics, Medical Research Center, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland.
    Objective: To compare the effectiveness of tonsillectomy and the long-term outcome of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome in patients fulfilling the classic diagnostic criteria and in those with regularly recurring fever as the only symptom or with onset of symptoms after age 5 years or both.

    Study Design: We reviewed the medical records of 3852 children who underwent tonsillectomy between 1990 and 2007 and identified 108 children who did so because of regularly recurring fevers. The patients were invited to an outpatient visit and were classified into 2 groups: those who met (N = 58) and those who did not meet (N = 50) Thomas diagnostic criteria. Read More

    Discontinuing colchicine in symptomatic carriers for MEFV (Mediterranean FeVer) variants.
    Clin Rheumatol 2017 Feb 27;36(2):421-425. Epub 2016 Sep 27.
    Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey.
    Familial Mediterranean fever (FMF) is inherited autosomal recessively; however, heterozygotes may express FMF phenotype. We aimed to define the characteristics of FMF patients heterozygous for MEFV (MEditerranean FeVer) mutations in whom colchicine was stopped after a period of treatment, with close follow-up. We reviewed the charts of 182 children who were heterozygous for MEFV variants. Read More

    Everolimus safety and efficacy for renal angiomyolipomas associated with tuberous sclerosis complex: a Spanish expanded access trial.
    Orphanet J Rare Dis 2016 Sep 26;11(1):128. Epub 2016 Sep 26.
    Inherited Renal Diseases, Department of Nephrology, Fundació Puigvert, REDINREN, IIB Sant Pau, Universitat Autónoma de Barcelona, Cartagena, 340-350, 08025, Barcelona, Spain.
    Background: Renal angiomyolipomas (AML) are usual manifestations of tuberous sclerosis complex (TSC) that may cause aneurism-related haemorrhages and renal impairment. Everolimus has emerged as an alternative to surgery/embolization. We provide further insight into everolimus safety and efficacy for TSC-related AML. Read More

    Periodic fevers and autoinflammatory syndromes in childhood.
    J Paediatr Child Health 2016 Sep;52(9):865-71
    General Medicine, The Sydney Children's Hospitals Network, New South Wales, Australia.
    Recurrent fever is a common presentation in paediatric practice and can be caused by a wide variety of diseases including autoinflammatory conditions. The innate immune system plays an essential role in the 'first line' response to infection through mediation of inflammatory responses. Inflammasomes are part of the regulatory process for this system and result in the production of the powerful pro-inflammatory cytokine interleukin-1B. Read More

    Efficacy of Omega-3 in Treatment of Recurrent Aphthous Stomatitis: A Randomised, Double-blind, Placebo-controlled Study.
    Chin J Dent Res 2016;19(3):159-64
    Objective: To evaluate the potential of omega-3 polyunsaturated fatty acid supplement as an effective, safe and inexpensive medicine for the treatment of recurrent aphthous stomatitis.

    Methods: In this double-blind clinical trial, 50 patients with recurrent aphthous stomatitis were randomly divided into the omega-3 group and placebo group. Patients in the omega-3 group received 1000 mg omega-3 group capsules (Daroupakhsh Company, Tehran, Iran) for 6 months; while those in the placebo group received placebo capsules with the same instructions. Read More

    Investigation of Behçet's Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey.
    Balkan Med J 2016 Jul 1;33(4):390-5. Epub 2016 Jul 1.
    Department of Internal Medicine, Gaziosmanpaşa University School of Medicine, Tokat, Turkey.
    Background: The Recurrent Aphthous Stomatitis (RAS) is the most frequently observed painful pathology of the oral mucosa in the society. It appears mostly in idiopathic form; however, it may also be related with systemic diseases like Behçet's Disease (BD).

    Aims: Determining the prevalence of RAS and BD in the Northern Anatolian Region, which is one of the important routes on the Antique Silk Road. Read More

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