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    Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study.
    An Bras Dermatol 2017 Sep-Oct;92(5):626-629
    Post-Graduation Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL)- Pelotas (RS), Brazil.
    Background: Recurrent aphthous stomatitis is a painful disorder of unknown etiology. It is among the most common oral mucosal lesions with high prevalence among young adults.

    Objectives: To conduct a population-based study with 18-year-old army recruiters to assess its prevalence and associated factors in male adolescents. Read More

    Exacerbation of Behçet's syndrome and familial Mediterranean fever with menstruation.
    Clin Exp Rheumatol 2017 Oct 24. Epub 2017 Oct 24.
    Istanbul University, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.
    Obectives: Menstruation triggers several conditions such as migraine, recurrent aphthous stomatitis and acne vulgaris in healthy individuals. There is evidence that Behçet's syndrome (BS) and familial Mediterranean fever (FMF) may exacerbate during menstruation. The aim is to assess whether BS and FMF patients experience menstrual flares. Read More

    A Dramatic Case of Odynophagia.
    Dysphagia 2017 Nov 11. Epub 2017 Nov 11.
    Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
    We report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. The severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ENT, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). During this time, the patient received central parenteral nutrition with an episode of catheter-related septicemia, and he came to require psychiatric assistance for autolytic ideation. Read More

    Atypical Afta Major Healing after Photodynamic Therapy.
    Case Rep Dent 2017 20;2017:8517470. Epub 2017 Sep 20.
    Diabetology, San Michele Hospital, Cagliari, Italy.
    The aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity clinical examination showed several major symptomatic ulcers, previously treated with topical and systemic therapies without any benefit. Read More

    Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design.
    Adv Pharm Bull 2017 Sep 25;7(3):441-450. Epub 2017 Sep 25.
    Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
    Purpose: Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Read More

    Investigation of dissolved cellulose in development of buccal discs for oromucosal drug delivery.
    Pharm Dev Technol 2017 Nov 9:1-10. Epub 2017 Nov 9.
    a Pharmaceutical Science Laboratory, Department of Biosciences, Faculty of Science and Engineering , Åbo Akademi University , Turku , FI , Finland.
    Mucoadhesive formulations have a wide scope of application for both systemic and local treatment of various diseases. In the case of recurrent aphthous stomatitis, to ensure effective therapy, the concentration of corticosteroids, and/or anesthetics at the mouth ulcer side should be maintained with minimal systemic absorption. Therefore, the aim of the study was to investigate cellulose-based formulations, in achieving suitable hardness, mucoadhesiveness, and sustained release of the active ingredients directed towards the mucosa for an extended period of time (∼4 h). Read More

    Approach to recurrent fever in childhood.
    Can Fam Physician 2017 Oct;63(10):756-762
    Professor in the Department of Paediatrics and the Department of Medicine at the University of Toronto and a staff rheumatologist in the Division of Rheumatology at The Hospital for Sick Children.
    Objective: To provide an approach to recurrent fever in childhood, explain when infections, malignancies, and immunodeficiencies can be excluded, and describe the features of periodic fever and other autoinflammatory syndromes.

    Sources Of Information: PubMed was searched for relevant articles regarding the pathogenesis, clinical findings, diagnosis, prognosis, and treatment of periodic fever and autoinflammatory syndromes.

    Main Message: Fever is a common sign of illness in children and is most frequently due to infection. Read More

    Diagnostic Criteria for Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome.
    Front Immunol 2017 24;8:1018. Epub 2017 Aug 24.
    Periodic Fevers Research Center, Institute of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica Sacro Cuore, Rome, Italy.
    Objective: To identify a set of variables that could discriminate patients with adult-onset periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome from subjects with fever of unknown origin (FUO).

    Methods: We enrolled 74 adults diagnosed with PFAPA syndrome according to the currently used pediatric diagnostic criteria and 62 additional patients with FUO. After having collected clinical and laboratory data from both groups, univariate and multivariate analyses were performed to identify the variables associated with PFAPA diagnosis. Read More

    The absence of an association between Interleukin 1β gene polymorphisms and recurrent aphthous stomatitis (RAS).
    Arch Oral Biol 2017 Dec 19;84:45-49. Epub 2017 Sep 19.
    Department of Oral Mucosa Diseases, University of Medical Sciences, Poznań, Poland.
    Objectives: Recurrent aphthous stomatitis (RAS) is a chronic, ulcerative disease with a probable polygenic mode of inheritance and complex etiology with a strong immunological background. The aim of the present study was to determine the possible association between two single nucleotide polymorphisms (SNPs) of the IL-1β gene: IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) and RAS susceptibility in a moderately large group of patients.

    Design: One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach. Read More

    Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis.
    Prague Med Rep 2017 ;118(2-3):81-86
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology. IL-2 and IFN-γ are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of IL-2 and IFN-γ genes could alter the cytokine production. Read More

    Measles Lymphadenopathy in a Child With PFAPA Syndrome.
    Pediatr Dev Pathol 2017 Jan 1:1093526617727970. Epub 2017 Jan 1.
    2 Division of Pediatric Rheumatology, Department of Pediatrics, University of British Columbia and 37210 British Columbia Children's Hospital , Vancouver, British Columbia, Canada.
    Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a common cause of periodic fever in children. The pathogenesis of PFAPA is unknown but likely involves immune system dysregulation and may be initiated by an environmental trigger. Tonsillectomy resolves or improves symptoms in some patients, but the reason for this is unknown; moreover, specific abnormalities in tonsillectomy specimens from PFAPA patients have not been described. Read More

    Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets.
    Nat Prod Res 2017 Sep 5:1-6. Epub 2017 Sep 5.
    a College of Pharmacy and College (Institute) of Integrative Medicine , Dalian Medical University , Dalian , PR China.
    Shuanghua Baihe tablet is a traditional Chinese patent medicine which showed special advantages in the treatment of recurrent aphthous stomatitis. Scientists have improved and implemented the LC-MS/MS method, which is specific and sensitive, for comparative pharmacokinetics study of five alkaloids, including palmatine, berberine, epiberberine, jatrorrhizine and coptisine in rat plasma after oral administration of Rhizoma Coptidis extract and Shuanghua Baihe tablets. The results showed that Shuanghua Baihe tablets could promote the absorption of these five alkaloids and improved their bioavailability compared with R. Read More

    Stress as a Cause of Recurrent Aphthous Stomatitis and Its Correlation with Salivary Stress Markers.
    Chin J Physiol 2017 08;60(4):226-230
    Department of Physiology, International Medical School, MSR Nagar, MSRIT Post, Bangalore, Karanataka 560054, India.
    Stress causes an increase in cortisol and amylase. Recurrent aphthous stomatitis (RAS) results due to a multitude of causes, amongst which stress is one of the most important. Aim of the study was to estimate the level of stress, serum cortisol, salivary cortisol, amylase and electrolytes in subjects with RAS. Read More

    Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis.
    Contemp Clin Dent 2017 Apr-Jun;8(2):259-263
    Department of Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    Background And Objective: Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS.

    Materials And Methods: Twenty-seven patients (13 males and 14 females, mean age of 32. Read More

    Colchicine: an ancient drug with novel applications.
    Br J Dermatol 2017 Aug 18. Epub 2017 Aug 18.
    Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD.
    Colchicine is a historic treatment for gout that has been used for more than a millennium. It is the treatment of choice for Familial Mediterranean Fever and its associated complication, amyloidosis. The 2009 FDA approval of colchicine as a new drug had research consequences. Read More

    Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study.
    PLoS One 2017 9;12(8):e0180939. Epub 2017 Aug 9.
    Department of Nephrology, Charité Universitätsmedizin, Berlin, Germany.
    Objectives: We examined the long-term effects of everolimus in patients with renal angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis.

    Methods: Following favorable results from the double-blind core phase of EXIST-2 (NCT00790400), patients were allowed to receive open-label everolimus (extension phase). Patients initially randomly assigned to everolimus continued on the same dose; those who were receiving placebo crossed over to everolimus 10 mg/day. Read More

    Evolving Frontiers in the Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Syndrome.
    Isr Med Assoc J 2017 Jul;19(7):444-447
    Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases Behçet's Disease Clinic, University of Siena, Siena, Italy.
    Background: Fevers recurring at a nearly predictable rate every 3-8 weeks are the signature symptom of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome, an acquired autoinflammatory disorder which recurs in association with at least one sign among aphthous stomatitis, pharyngitis, and/or cervical lymph node enlargement without clinical signs related to upper respiratory airways or other localized infections. The disease usually has a rather benign course, although it might relapse during adulthood after a spontaneous or treatment-induced resolution in childhood. The number of treatment choices currently available for PFAPA syndrome has grown in recent years, but data from clinical trials dedicated to this disorder are limited to small cohorts of patients or single case reports. Read More

    Patient-reported outcome measures in recurrent aphthous stomatitis: A critical assessment of quality properties.
    Oral Dis 2017 Nov 30;23(8):1168-1179. Epub 2017 Aug 30.
    UCL Eastman Dental Institute, London, UK.
    Objectives: To analyse the range of existing patient-reported outcome measures (PROMs) used in studies of recurrent aphthous stomatitis (RAS) and to evaluate their quality properties via the assessment of psychometric properties and interpretability.

    Materials And Methods: Electronic databases were searched to identify relevant publications related to PROMs used in RAS. Publications were selected based on predefined criteria. Read More

    Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic.
    J Oral Pathol Med 2017 Oct 4;46(9):821-828. Epub 2017 Sep 4.
    Department of Otorhinolaryngology, Head and Neck Surgery, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP-EPM), Sao Paulo, Brazil.
    Background: There are indications that Th1 polarization of immune response plays an important role in the pathogenesis of recurrent aphthous stomatitis (RAS), and that the use of probiotics can stimulate immune regulatory activity, influencing the course of the disease. The aim of this study was to characterize the initial immune profile of RAS patients and evaluate clinical and serological response following a challenge with symbiotic treatment containing fructooligosaccharide, Lactobacillus, and Bifidobacterium.

    Methods: The immune responses of the 45 patients with RAS, submitted to symbiotic or placebo for 120 days, in relation to 30 RAS-free controls, were evaluated over a period of 6 months. Read More

    Self-reported oral health and xerostomia in adult patients with celiac disease versus a comparison group.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Aug 23;124(2):152-156. Epub 2017 May 23.
    Department of Oral Biochemistry, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
    Objectives: This study aimed to assess the impact of celiac disease (CD) on oral health and xerostomia.

    Study Design: Members of the Dutch Celiac Society (n = 5522) were invited to complete an online questionnaire based on the Oral Health Impact Profile 14 (OHIP-14) and Xerostomia Inventory (XI). Acquaintances and partners of the CD respondents served as the comparison group. Read More

    Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome.
    Clin Rheumatol 2017 Jul 26. Epub 2017 Jul 26.
    Division of Pediatric Infectious Diseases, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.
    The objective of this study is to compare the histology and immune cell composition of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome to those from patients with obstructive sleep apnea (OSA). Patients with PFAPA and age-matched controls with OSA who had undergone tonsillectomy at Vanderbilt Children's Hospital were recruited. After informed consent, archival paraffin-embedded, formalin-fixed tonsil tissues were obtained. Read More

    Delivering resveratrol on the buccal mucosa using mucoadhesive tablets: a potential treatment strategy for inflammatory oral lesions.
    Curr Drug Deliv 2017 Jul 26. Epub 2017 Jul 26.
    Faculty of Dentistry, Federal University of Juiz de Fora, 36036-900, Juiz de Fora, MG. Brazil.
    Resveratrol is a polyphenol which has been gaining momentum in therapeutics in the last years. In this work, we hypothesized that it could act in the prophylaxis and/or treatment of inflammatory lesions of the oral cavity through its delivery from two different formulations of buccal mucoadhesive tablets. This was assessed through permeation studies, in order to verify the drug diffusivity through the buccal mucosa, using a porcine model to predict the human in vivo behavior. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Enamel defects and aphthous stomatitis in celiac and healthy subjects: Systematic review and meta-analysis of controlled studies.
    J Dent 2017 Oct 5;65:1-10. Epub 2017 Jul 5.
    Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. Electronic address:
    Objectives: The aim of this systematic review was to compare the presence of enamel defects and aphthous stomatitis between celiac patients and healthy controls.

    Data Sources: A systematic review of articles selected from MEDLINE, EMBASE and Google Scholar was performed by two independent operators. Additional studies hand-searched and found in the principal dental and gastroenterology journals were included. Read More

    [Soluble programmed death-1 and soluble programmed death ligand 1 protein expression and immune status in patients with recurrent aphthous ulcer].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Jun;35(3):286-290
    Dept. of Periodontal and Oral Mucosal Diseases, The Affiliated Stomatological Hospital of Guizhou Medical University, Guiyang 550004, China.
    Objective: This study aims to investigate the possible role and significance of soluble programmed death-1 (sPD-1)  /soluble programmed death ligand 1 (sPD-L1) in the immune pathogeneses of recurrent aphthous ulcer (RAU).

    Methods: A total of 30 RAU cases (18 cases of minor RAU, 5 cases of major RAU, and 7 cases of herpetiform ulcers) were enrolled in this study. A total of 18 healthy people served as controls. Read More

    [Behçet's disease: Intracardiac thrombosis (a description of two cases and a review of literature)].
    Ter Arkh 2017;89(5):79-82
    V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
    Behçet's disease (BD) is systemic vasculitis of unknown etiology, which is more common in the countries located along the Great Silk Road. The disease is diagnosed if a patient has 4 key diagnostic signs: aphthous stomatitis, genital sores, and eye and skin lesions. Vascular diseases referred to as minor criteria for BD are characterized by the formation of aneurysms and thrombosis, predominantly in the venous bed. Read More

    Afr J Tradit Complement Altern Med 2017 13;14(2):311-318. Epub 2017 Jan 13.
    Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, P.O. Box 98615-538, Zabol, 9861335856 Iran.
    Background: Nowadays, the demand for antibacterial fabrics has increased. White alum is used for oral aphthous ulcers treatment in traditional medicine of Sistan city, Sistan and Baluchistan Province, Iran, and also as a flocculent for water purification. This study is aimed to evaluate the effect of concentration and time on antibacterial activity of white alum on Escherichia coli O157:H7. Read More

    Retin Cases Brief Rep 2017 May 29. Epub 2017 May 29.
    *Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah; and †Department of Pediatric Immunology and Rheumatology, University of Utah, Salt Lake City, Utah.
    Background/purpose: To report two novel cases of intermediate uveitis associated with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis syndrome.

    Methods: Observational case reports and review of the literature.

    Results: Both patients in this report had an established diagnosis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis syndrome before the onset of ocular inflammation. Read More

    Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update.
    Curr Opin Rheumatol 2017 Sep;29(5):493-499
    aNational Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland bDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee cGoryeb Children's Hospital, Morristown Medical Center, Morristown, New Jersey, USA.
    Purpose Of Review: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is considered the most common periodic fever syndrome of childhood. Although it was first described three decades ago, the pathogenesis has been poorly understood. Recent studies on the heritability and immunology of the disorder have begun to shed light into the mechanisms of this autoinflammatory disorder. Read More

    Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis.
    J Oral Pathol Med 2017 Nov 11;46(10):1030-1035. Epub 2017 Jun 11.
    Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population.

    Methods: A total of 248 subjects, 184 healthy controls, and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTRs) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C, and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Read More

    Assessment of Oxidant-Antioxidant Status and Stress Factor in Recurrent Aphthous Stomatitis Patients: Case Control Study.
    J Clin Diagn Res 2017 Mar 1;11(3):ZC01-ZC04. Epub 2017 Mar 1.
    Professor and Head, Department of Oral Pathology, Azeezia College of Dental Science and Research, Kerala University of Health Sciences, Kollam, Kerala, India.
    Introduction: Despite its vast occurrence, the aetiology of Recurrent Aphthous Stomatitis (RAS) still remains unknown and its aetiology is multifactorial. The factors believed to be associated with the aetiology of RAS, may disturb the equilibrium of oxidant-antioxidant status of the organism and may accelerate the formation of free radicals, resulting in Oxidative Stress (OS). Psychological stress is believed to act as a triggering factor or modifying factor for RAS. Read More

    Georgian Med News 2017 Mar(264):115-119
    State Establishment "Dnipropetrovsk Medical Academy", *Kharkiv National Medical University, Ukraine.
    Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to determine the effects of ozone on the morphofunctional peculiarities of the soft tissues in modeling chronic recurrent aphthous stomatitis. We performed experimental investigation for study of the morpho-functional state of tissues of the oral mucosa in CRAS with using of previously proposed and widely used modeling scheme with ovalbumin and aluminum hydroxide. Read More

    [Everolimus in Daily Clinical Practice Focusing to Oral Mucosa Damage Issues - Single Oncology Centre Experience within the Course of the Year 2016].
    Klin Onkol 2017 ;30(Supplementum1):195-197
    Background: Oral mucositis, mTOR associated stomatitis, is a major complication in everolimus (EVE) treatment with an incidence of 44-64%. The management of it in the daily practice has not been described enough, so far.

    Patients And Methods: Retrospective analysis of patients treated with EVE in 2016 at our center, n = 42 patients (69% female), median age 66 (37-81) years, breast cancer in 20 (48%) and renal cell carcinoma in 22 (52%), starting EVE dose of 10mg/day in 34 (81%) and 5mg/day in 8 (19%) patients. Read More

    Anti-TNF Treatment for Extraintestinal Manifestations of Inflammatory Bowel Disease in the Swiss IBD Cohort Study.
    Inflamm Bowel Dis 2017 Jul;23(7):1174-1181
    1Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland; 2Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; 3Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland; 4Division of Gastroenterology and Hepatology, University Hospital Lausanne-CHUV, Lausanne, Switzerland; 5Division of Gastroenterology, Lindenhof Spital, Bern, Switzerland; 6Division of Gastroenterology and Hepatology, Spital Tiefenau, Bern, Switzerland; 7Crohn and Colitis Center, Clinique La Source-Beaulieu, Lausanne, Switzerland; 8Praxis Römerhof, Olten, Switzerland; 9Institute of Social and Preventive Medicine (IUMSP), University of Lausanne, Lausanne, Switzerland; 10Department of Gastroenterology, Clinic for Visceral Surgery and Medicine, Inselspital, University Hospital of Bern, Bern, Switzerland; 11Department of Gastroenterology, See Spital, Horgen, Switzerland; 12Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; and 13Division of Gastroenterology, The National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
    Background: Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) in EIM management. We assessed the effect of 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on EIM evolution. Read More

    The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 28;123(6):675-679. Epub 2017 Feb 28.
    Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
    Objective: The aim of the study was to assess the efficacy of 2 different concentrations of minocycline mouthwashes on the symptoms of recurrent aphthous stomatitis (RAS).

    Study Design: The 2-year study was designed as a randomized, double-blind, crossover study. Healthy patients with frequent RAS episodes received 2 sealed and computer-randomized marked kits containing minocycline mouthwashes (0. Read More

    Salivary Alpha-Amylase Enzyme, Psychological Disorders, and Life Quality in Patients with Recurrent Aphthous Stomatitis.
    Int J Dent 2017 19;2017:5269856. Epub 2017 Mar 19.
    São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
    Objective. The aim of this study was to evaluate stress, anxiety, and salivary alpha-amylase (SAA) activity in patients with recurrent aphthous stomatitis (RAS). The impact of this disease on the life quality was also evaluated. Read More

    Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.
    Med Oral Patol Oral Cir Bucal 2017 May 1;22(3):e297-e306. Epub 2017 May 1.
    University of Talca, Lircay Av. S/N, Talca, Chile, Zip code 3460000,
    Background: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce.

    Material And Methods: This study investigated the frequency of OD in a Chilean population. Read More

    Recurrent Aphthous Stomatitis: A Review.
    J Clin Aesthet Dermatol 2017 Mar 1;10(3):26-36. Epub 2017 Mar 1.
    Broward Health Medical Center, Fort Lauderdale, Florida.
    Aphthous stomatitis is a painful and often recurrent inflammatory process of the oral mucosa that can appear secondary to various well-defined disease processes. Idiopathic recurrent aphthous stomatitis is referred to as recurrent aphthous stomatitis. The differential diagnosis for recurrent aphthous ulcerations is extensive and ranges from idiopathic benign causes to inherited fever syndromes, to connective tissue disease, or even inflammatory bowel diseases. Read More

    Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: A randomized controlled split mouth clinical study.
    J Photochem Photobiol B 2017 May 22;170:1-5. Epub 2017 Mar 22.
    Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey.
    The present randomized controlled split mouth clinical study aimed to investigate the efficacy of Er,Cr:YSGG laser irradiation on pain reduction and healing rate of recurrent aphthous stomatitis. 40 patients with RAS were recruited for this study and RAS ulcerations of each patient were randomly assigned to the control or test group. In the test group, Er,Cr:YSGG laser with non-contact mode was used to irradiate RAS lesions. Read More

    Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review.
    Lasers Med Sci 2017 May 27;32(4):953-963. Epub 2017 Mar 27.
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.
    The aim of this systematic review was to assess a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS). The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency. A PICO approach was used as a search strategy in Medline, Embase and Cochrane databases. Read More

    Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children.
    Wiad Lek 2017;70(1):144-147
    State Higher Educational Institution "Ivano-Frankivsk National Medical University", Department Of Children Diseases Of Postgraduate Medical Education Faculty, Ivano-Frankivsk, Ukraine.
    Introduction: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome refers to a group of primary immunodeficiencies, namely autoinflammatory diseases. Most pediatricians and otolaryngologists do not suspect PFAPA syndrome when treating recurrent pharyngitis (according to Ukrainian classification - tonsillitis) and stomatitis. Therefore, patients with a given syndrome receive unnecessary treatment (antibiotic therapy or antiviral drugs) and the diagnosis is made late. Read More

    Unique clinical presentations of pityriasis rosea: aphthous ulcers, vesicles and inverse distribution of lesions.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Pityriasis Rosea (PR) is a common skin disorderencountered in daily practice. Although its etiologyhas not been established, there has been widespreadresearch into possibilities. The lack of its characteristicmanifestations, specifically the herald patch andtruncal involvement, can lead to pitfalls in diagnosis. Read More

    The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints.
    BMC Oral Health 2017 Mar 21;17(1):67. Epub 2017 Mar 21.
    Faculty of Engineering, Department of Genetics and Bioengineering, Yeditepe University, İstanbul, Turkey.
    Background: The oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. Read More

    Essential Oils of Myrtaceae Species Growing Wild in Tunisia: Chemical Variability and Antifungal Activity Against Biscogniauxia mediterranea, the Causative Agent of Charcoal Canker.
    Chem Biodivers 2017 Jul 23;14(7). Epub 2017 Jun 23.
    Laboratory of Nanobiotechnology and Medicinal Plants, Department of Biology, National Institute of Applied Science and Technology (INSAT), University of Carthage, BP 676, 1080, Tunis Cedex, Tunisia.
    The chemical composition of five Eucalyptus species and five Myrtus communis L. populations was investigated using GC/MS and GC-FID. For Eucalyptus essential oils, 32 compounds, representing 88. Read More

    Contact Allergy to (Ingredients of) Toothpastes.
    Dermatitis 2017 Mar/Apr;28(2):95-114
    From acdegroot publishing, Wapserveen, The Netherlands.
    The literature on contact allergy to (ingredients of) toothpastes is critically reviewed. We have found 47 case reports, small case series (n = 2-5) and citations published between 1900 and 2016 describing more than 60 patients allergic to toothpastes, and in addition 3 larger case series and many descriptions of toothpaste allergy among selected groups of patients. Allergic reactions usually manifest as cheilitis with or without dermatitis around the mouth, less frequently by oral symptoms. Read More

    Clinical Evaluation of High and Low-Level Laser Treatment (CO2vsInGaAlP Diode Laser) for Recurrent Aphthous Stomatitis.
    J Dent (Shiraz) 2017 Mar;18(1):17-23
    Dept. of Oral Medicine, Dental School, Azad University, Tehran, Iran.
    Statement Of The Problem: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral cavity. Due to its multifactorial nature, there is no definitive treatment for RAS. Laser therapy is one of the suggested treatments to reduce patient's discomfort. Read More

    Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome.
    Rheumatol Int 2017 Jun 7;37(6):883-889. Epub 2017 Mar 7.
    Pediatric Rheumatology, Goryeb Children's Hospital, Atlantic Health System, Morristown Medical Center/Overlook Hospital, Morristown, NJ, USA.
    To assess the practice patterns of pediatric rheumatology and infectious diseases subspecialists in the diagnosis and treatment of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. An online survey assessing diagnostic and treatment approaches was sent to 424 members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) and 980 members of the Pediatric Infectious Disease Society (PIDS). 277 physicians (123 from CARRA and 154 from PIDS representing 21% of the total membership) completed the survey. Read More

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