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    [Behçet's disease: Intracardiac thrombosis (a description of two cases and a review of literature)].
    Ter Arkh 2017 ;89(5):79-82
    V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
    Behçet's disease (BD) is systemic vasculitis of unknown etiology, which is more common in the countries located along the Great Silk Road. The disease is diagnosed if a patient has 4 key diagnostic signs: aphthous stomatitis, genital sores, and eye and skin lesions. Vascular diseases referred to as minor criteria for BD are characterized by the formation of aneurysms and thrombosis, predominantly in the venous bed. Read More

    Retin Cases Brief Rep 2017 May 29. Epub 2017 May 29.
    *Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah; and †Department of Pediatric Immunology and Rheumatology, University of Utah, Salt Lake City, Utah.
    Background/purpose: To report two novel cases of intermediate uveitis associated with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis syndrome.

    Methods: Observational case reports and review of the literature.

    Results: Both patients in this report had an established diagnosis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis syndrome before the onset of ocular inflammation. Read More

    Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update.
    Curr Opin Rheumatol 2017 May 26. Epub 2017 May 26.
    aNational Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland bDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee cGoryeb Children's Hospital, Morristown Medical Center, Morristown, New Jersey, USA.
    Purpose Of Review: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is considered the most common periodic fever syndrome of childhood. Although it was first described three decades ago, the pathogenesis has been poorly understood. Recent studies on the heritability and immunology of the disorder have begun to shed light into the mechanisms of this autoinflammatory disorder. Read More

    Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis.
    J Oral Pathol Med 2017 May 20. Epub 2017 May 20.
    Clinic of Stomatology, Institution Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population.

    Methods: A total of 248 subjects, 184 healthy controls, and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86 bp variable number of tandem repeats (VNTRs) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C, and IL-6R+48992A>C by polymerase chain reaction (PCR) methods. Read More

    Assessment of Oxidant-Antioxidant Status and Stress Factor in Recurrent Aphthous Stomatitis Patients: Case Control Study.
    J Clin Diagn Res 2017 Mar 1;11(3):ZC01-ZC04. Epub 2017 Mar 1.
    Professor and Head, Department of Oral Pathology, Azeezia College of Dental Science and Research, Kerala University of Health Sciences, Kollam, Kerala, India.
    Introduction: Despite its vast occurrence, the aetiology of Recurrent Aphthous Stomatitis (RAS) still remains unknown and its aetiology is multifactorial. The factors believed to be associated with the aetiology of RAS, may disturb the equilibrium of oxidant-antioxidant status of the organism and may accelerate the formation of free radicals, resulting in Oxidative Stress (OS). Psychological stress is believed to act as a triggering factor or modifying factor for RAS. Read More

    Georgian Med News 2017 Mar(264):115-119
    State Establishment "Dnipropetrovsk Medical Academy", *Kharkiv National Medical University, Ukraine.
    Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to determine the effects of ozone on the morphofunctional peculiarities of the soft tissues in modeling chronic recurrent aphthous stomatitis. We performed experimental investigation for study of the morpho-functional state of tissues of the oral mucosa in CRAS with using of previously proposed and widely used modeling scheme with ovalbumin and aluminum hydroxide. Read More

    [Everolimus in Daily Clinical Practice Focusing to Oral Mucosa Damage Issues - Single Oncology Centre Experience within the Course of the Year 2016].
    Klin Onkol 2017 ;30(Supplementum1):195-197
    Background: Oral mucositis, mTOR associated stomatitis, is a major complication in everolimus (EVE) treatment with an incidence of 44-64%. The management of it in the daily practice has not been described enough, so far.

    Patients And Methods: Retrospective analysis of patients treated with EVE in 2016 at our center, n = 42 patients (69% female), median age 66 (37-81) years, breast cancer in 20 (48%) and renal cell carcinoma in 22 (52%), starting EVE dose of 10mg/day in 34 (81%) and 5mg/day in 8 (19%) patients. Read More

    Anti-TNF Treatment for Extraintestinal Manifestations of Inflammatory Bowel Disease in the Swiss IBD Cohort Study.
    Inflamm Bowel Dis 2017 Jul;23(7):1174-1181
    1Division of Gastroenterology and Hepatology, Triemli Hospital Zurich, Zurich, Switzerland; 2Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; 3Division of Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland; 4Division of Gastroenterology and Hepatology, University Hospital Lausanne-CHUV, Lausanne, Switzerland; 5Division of Gastroenterology, Lindenhof Spital, Bern, Switzerland; 6Division of Gastroenterology and Hepatology, Spital Tiefenau, Bern, Switzerland; 7Crohn and Colitis Center, Clinique La Source-Beaulieu, Lausanne, Switzerland; 8Praxis Römerhof, Olten, Switzerland; 9Institute of Social and Preventive Medicine (IUMSP), University of Lausanne, Lausanne, Switzerland; 10Department of Gastroenterology, Clinic for Visceral Surgery and Medicine, Inselspital, University Hospital of Bern, Bern, Switzerland; 11Department of Gastroenterology, See Spital, Horgen, Switzerland; 12Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; and 13Division of Gastroenterology, The National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
    Background: Extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) are frequently observed. Little is known about the efficacy of anti-tumor necrosis factor (TNF) in EIM management. We assessed the effect of 3 anti-TNF agents (infliximab, adalimumab, and certolizumab pegol) on EIM evolution. Read More

    The efficacy of minocycline mouth rinses on the symptoms associated with recurrent aphthous stomatitis: a randomized, double-blind, crossover study assessing different doses of oral rinse.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jun 28;123(6):675-679. Epub 2017 Feb 28.
    Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
    Objective: The aim of the study was to assess the efficacy of 2 different concentrations of minocycline mouthwashes on the symptoms of recurrent aphthous stomatitis (RAS).

    Study Design: The 2-year study was designed as a randomized, double-blind, crossover study. Healthy patients with frequent RAS episodes received 2 sealed and computer-randomized marked kits containing minocycline mouthwashes (0. Read More

    Salivary Alpha-Amylase Enzyme, Psychological Disorders, and Life Quality in Patients with Recurrent Aphthous Stomatitis.
    Int J Dent 2017 19;2017:5269856. Epub 2017 Mar 19.
    São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
    Objective. The aim of this study was to evaluate stress, anxiety, and salivary alpha-amylase (SAA) activity in patients with recurrent aphthous stomatitis (RAS). The impact of this disease on the life quality was also evaluated. Read More

    Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.
    Med Oral Patol Oral Cir Bucal 2017 May 1;22(3):e297-e306. Epub 2017 May 1.
    University of Talca, Lircay Av. S/N, Talca, Chile, Zip code 3460000,
    Background: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce.

    Material And Methods: This study investigated the frequency of OD in a Chilean population. Read More

    Recurrent Aphthous Stomatitis: A Review.
    J Clin Aesthet Dermatol 2017 Mar 1;10(3):26-36. Epub 2017 Mar 1.
    Broward Health Medical Center, Fort Lauderdale, Florida.
    Aphthous stomatitis is a painful and often recurrent inflammatory process of the oral mucosa that can appear secondary to various well-defined disease processes. Idiopathic recurrent aphthous stomatitis is referred to as recurrent aphthous stomatitis. The differential diagnosis for recurrent aphthous ulcerations is extensive and ranges from idiopathic benign causes to inherited fever syndromes, to connective tissue disease, or even inflammatory bowel diseases. Read More

    Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: A randomized controlled split mouth clinical study.
    J Photochem Photobiol B 2017 May 22;170:1-5. Epub 2017 Mar 22.
    Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey.
    The present randomized controlled split mouth clinical study aimed to investigate the efficacy of Er,Cr:YSGG laser irradiation on pain reduction and healing rate of recurrent aphthous stomatitis. 40 patients with RAS were recruited for this study and RAS ulcerations of each patient were randomly assigned to the control or test group. In the test group, Er,Cr:YSGG laser with non-contact mode was used to irradiate RAS lesions. Read More

    Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review.
    Lasers Med Sci 2017 May 27;32(4):953-963. Epub 2017 Mar 27.
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.
    The aim of this systematic review was to assess a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS). The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency. A PICO approach was used as a search strategy in Medline, Embase and Cochrane databases. Read More

    Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children.
    Wiad Lek 2017;70(1):144-147
    State Higher Educational Institution "Ivano-Frankivsk National Medical University", Department Of Children Diseases Of Postgraduate Medical Education Faculty, Ivano-Frankivsk, Ukraine.
    Introduction: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome refers to a group of primary immunodeficiencies, namely autoinflammatory diseases. Most pediatricians and otolaryngologists do not suspect PFAPA syndrome when treating recurrent pharyngitis (according to Ukrainian classification - tonsillitis) and stomatitis. Therefore, patients with a given syndrome receive unnecessary treatment (antibiotic therapy or antiviral drugs) and the diagnosis is made late. Read More

    The investigation of Helicobacter pylori in the dental biofilm and saliva samples of children with dyspeptic complaints.
    BMC Oral Health 2017 Mar 21;17(1):67. Epub 2017 Mar 21.
    Faculty of Engineering, Department of Genetics and Bioengineering, Yeditepe University, İstanbul, Turkey.
    Background: The oral cavity can be an extra-gastric reservoir for Helicobacter pylori (H.pylori). This can play a role in the pathogenesis of halitosis, glossitis, recurrent aphthous stomatitis, and dental caries. Read More

    Contact Allergy to (Ingredients of) Toothpastes.
    Dermatitis 2017 Mar/Apr;28(2):95-114
    From acdegroot publishing, Wapserveen, The Netherlands.
    The literature on contact allergy to (ingredients of) toothpastes is critically reviewed. We have found 47 case reports, small case series (n = 2-5) and citations published between 1900 and 2016 describing more than 60 patients allergic to toothpastes, and in addition 3 larger case series and many descriptions of toothpaste allergy among selected groups of patients. Allergic reactions usually manifest as cheilitis with or without dermatitis around the mouth, less frequently by oral symptoms. Read More

    Clinical Evaluation of High and Low-Level Laser Treatment (CO2vsInGaAlP Diode Laser) for Recurrent Aphthous Stomatitis.
    J Dent (Shiraz) 2017 Mar;18(1):17-23
    Dept. of Oral Medicine, Dental School, Azad University, Tehran, Iran.
    Statement Of The Problem: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral cavity. Due to its multifactorial nature, there is no definitive treatment for RAS. Laser therapy is one of the suggested treatments to reduce patient's discomfort. Read More

    Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome.
    Rheumatol Int 2017 Jun 7;37(6):883-889. Epub 2017 Mar 7.
    Pediatric Rheumatology, Goryeb Children's Hospital, Atlantic Health System, Morristown Medical Center/Overlook Hospital, Morristown, NJ, USA.
    To assess the practice patterns of pediatric rheumatology and infectious diseases subspecialists in the diagnosis and treatment of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. An online survey assessing diagnostic and treatment approaches was sent to 424 members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) and 980 members of the Pediatric Infectious Disease Society (PIDS). 277 physicians (123 from CARRA and 154 from PIDS representing 21% of the total membership) completed the survey. Read More

    Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis.
    Med Clin (Barc) 2017 Feb 18. Epub 2017 Feb 18.
    Centro Odontológico M'fedal Afailal Bab Okla, Tetuán, Marruecos.
    Background And Objective: Despite the high prevalence of recurrent aphthous stomatitis (RAS), its etiology is not yet completely clear and there is no completely remedial treatment available at present. The objective of this study was to evaluate the clinical efficacy and safety of 4 treatments (silver nitrate, propolis, rhubarb and walnut) for RAS.

    Patients And Method: A randomized clinical trial was conducted with 125 patients with minor aphthae, including 25 patients per group: cauterization with silver nitrate, propolis, rhubarb extract, walnut extract and placebo. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants?
    Pediatr Int 2017 Jun 24;59(6):655-660. Epub 2017 Apr 24.
    Departments of Pediatric Immunology-Rheumatology, Uludag University Faculty of Medicine, Görükle, Bursa, Turkey.
    Background: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most frequent repetitive fever syndrome in childhood. It is characterized by fever episodes lasting for approximately 3-6 days, once every 3-8 weeks.

    Methods: Clinical and laboratory data for PFAPA syndrome patients between January 2010 and December 2014 followed up at a tertiary pediatric care hospital were reviewed. Read More

    Clinacanthus nutans: a review on ethnomedicinal uses, chemical constituents and pharmacological properties.
    Pharm Biol 2017 Dec;55(1):1093-1113
    a Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link , Gadong , Brunei Darussalam.
    Context: Medicinal plants have attracted global attention for their hidden therapeutic potential. Clinacanthus nutans (Burm.f) Lindau (Acanthaceae) (CN) is endemic in Southeast Asia. Read More

    Exploring the Molecular Mechanism and Biomarker of Recurrent Aphthous Stomatitis Based on Gene Expression Microarray.
    Clin Lab 2017 Feb;63(2):249-253
    Background: Recurrent aphthous stomatitis (RAS) is one of the most common chronic oral diseases with morbidity ranging from 5% to 20%. The pathogenesis is still not fully understood though immune dysregulation and local trauma have been implicated and the curative effect that can be achieved through current therapy is mainly to alleviate the pain. So, the understanding of its molecular mechanisms can allow the prevention and treatment of RAS at the molecular level. Read More

    An Up-to-date Approach to a Patient with a Suspected Autoinflammatory Disease.
    Rambam Maimonides Med J 2017 Jan 30;8(1). Epub 2017 Jan 30.
    Rheumatology Unit, Sheba Medical Center, Tel HaShomer Hospital, Tel Aviv, Israel.
    Autoinflammatory diseases (AID) are characterized by seemingly unprovoked self-limited attacks of fever and systemic inflammation potentially leading to amyloidosis. Familial Mediterranean fever (FMF) is the most common AID and therefore the most studied. Besides FMF, the other main hereditary AID are tumor necrosis factor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency (MKD), and cryopyrin-associated periodic fever syndrome (CAPS). Read More

    An evaluation of the efficacy of a topical gel with Triester Glycerol Oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: A randomized, double-blind, placebo-controlled clinical trial.
    Med Oral Patol Oral Cir Bucal 2017 Mar 1;22(2):e159-e166. Epub 2017 Mar 1.
    Istanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, 34093 Istanbul, Turkey,
    Background: Triester glycerol oxide gel (Protefix® Queisser Pharma, Germany) is a new topical agent that has the property of adherence to the oral mucosa by forming a lipid film which protects against mechanical trauma and may help to reduce oral tissue moisture loss and inflammation. The aim of this clinical trial was to determine the efficacy of a topical TGO gel and to also compare it with triamcinolone acetonide pomade in the treatment of minor recurrent aphthous stomatitis.

    Material And Methods: This study was a randomized, double-blind, placebo-controlled clinical trial and 180 patients with the complaint of minor aphthous ulcers were enrolled in this study. Read More

    Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome.
    J Immunol 2017 Mar 30;198(5):2063-2069. Epub 2017 Jan 30.
    Pediatric Rheumatology Unit of Western Switzerland, Pediatric Department, University Hospital Center Vaudois, University of Lausanne, 1011 Lausanne, Switzerland;
    Periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is a relatively common autoinflammatory condition that primarily affects children. Although tendencies were reported for this syndrome, genetic variations influencing risk and disease progression are poorly understood. In this study, we performed next-generation sequencing for 82 unrelated PFAPA patients and identified a frameshift variant in the CARD8 gene (CARD8-FS). Read More

    [Preparation and clinical observation of Koukuining granules in 50 patients with recurrent aphthous ulcer].
    Shanghai Kou Qiang Yi Xue 2016 Oct;25(5):579-582
    Stomatological Hospital of Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration. Jinan 250012, China
    Purpose: To prepare Koukuining granules and observe its efficiency in the treatment of recurrent aphthas ulce (RAU).

    Methods: In accordance with the theories of traditional Chinese medicine, the prescriptions of Koukuining granules were composed of rhizoma coptidis, radix scutellariae and other Chinese herbs, and the preparation procedure was conducted by means of wet granulation technology. One hundred patients with RAU were randomly divided into experimental group and control group equally. Read More

    Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review.
    Scientifica (Cairo) 2016 18;2016:9062430. Epub 2016 Dec 18.
    The Hospital of Anhui Province, Hefei 230001, China.
    Objectives. Laser therapy is a promising new treatment for patients with recurrent aphthous stomatitis (RAS). However, the clinical effect and security issue of laser therapy remain controversial. Read More

    Efficacy and safety of Chinese patent medicines in the treatment of recurrent aphthous stomatitis: A systematic review.
    J Am Dent Assoc 2017 Jan;148(1):17-25
    Background: Recurrent aphthous stomatitis (RAS) is the most common chronic oral mucosal condition of the oral cavity. Investigators in clinical trials have evaluated the effectiveness of Chinese patent medicines in the treatment of RAS. However, the results are conflicting rather than conclusive. Read More

    Enzymatic antioxidants status in patients with recurrent aphthous stomatitis.
    J Oral Pathol Med 2017 Jan 5. Epub 2017 Jan 5.
    Department of Stomatology, Bethune International Peace Hospital, Shijiazhuang, China.
    Background: Oxidative stress (OS) has been thought to play a main role in the etiopathogenesis of recurrent aphthous stomatitis (RAS), which is one of the most common oral mucosal diseases characterized by recurrent and painful oral ulcers. The aim of this investigation was to evaluate the enzymatic antioxidants status in patients with RAS in the active stage and remission stage.

    Methods: Ninety-seven patients with idiopathic minor RAS and 102 race-, age- and gender-matched healthy individuals were recruited. Read More

    Is there a role of food additives in recurrent aphthous stomatitis? A prospective study with patch testing.
    Int J Dermatol 2017 Mar 30;56(3):302-306. Epub 2016 Dec 30.
    Hacettepe University, School of Medicine, Department of Dermatology, Ankara, Turkey.
    Background: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS.

    Methods: This prospective study included 24 patients with RAS and 22 healthy controls. Read More

    Status of Neutrophils, Lymphocytes and Platelets in Patients with Recurrent Aphthous Stomatitis: A Retrospective Study.
    Iran J Otorhinolaryngol 2016 Nov;28(89):421-424
    Department of Otorhinolaryngology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
    Introduction: The aim of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in patients with recurrent aphthous stomatitis (RAS).

    Materials And Methods: Eighty patients who were diagnosed with RAS between January 2014 and January 2016 were included in this study. Eighty age- and gender-matched healthy subjects were also enrolled as a control group. Read More

    Familial Mediterranean fever with P369S/R408Q exon3 variant in pyrin presenting as symptoms of PFAPA.
    Mod Rheumatol 2017 Mar;27(2):356-359
    c Department of Infection and Host Defense, Graduate School of Medicine , Shinshu University , Matsumoto , Japan.
    Familial Mediterranean fever (FMF) can be classified into typical and incomplete/atypical types. Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome-like symptoms have been found in atypical type carrying P369S-R408Q mutations in the responsible gene MEFV. A 28-year-old female with recurrent fever and her young sisters and mother, all of whom had tonsillectomy for tonsillitis, carried heterozygous alterations involving E148Q/P369S/R408Q. Read More

    Mumps, measles and rubella vaccination in children with PFAPA syndrome.
    Vaccine 2016 Nov 27;34(48):5903-5906. Epub 2016 Oct 27.
    Department and Clinic of Paediatric Infectious Diseases, Wroc?aw Medical University, 2-2A Cha?ubi?skiego, 50-368 Wroc?aw, Poland. Electronic address:
    There is no published data regarding immunologic response to vaccinations in children with PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis). The aim of this study was to evaluate mumps, measles and rubella immunity in children with PFAPA. 31 children with PFAPA syndrome and 22 healthy children (control group - CG) were recruited to the study. Read More

    Different modalities for treatment of recurrent aphthous stomatitis. A Randomized clinical trial.
    J Clin Exp Dent 2016 Dec 1;8(5):e517-e522. Epub 2016 Dec 1.
    Professor. Department of Pharmacognosy, National Research Centre, Giza, Egypt.
    Background: The underlying etiology of recurrent aphthous stomatitis (RAS) is unclear and treatment aims to provide symptomatic and faster relief. This study compared the efficacy of diode laser, a herbal combination of Acacia nilotica and Licorice (A and L) and Amlexanox in the management of RAS.

    Material And Methods: Sixty patients with minor aphthae were selected and randomly divided into four groups of 15 each. Read More

    Clinical phenotype of recurrent aphthous stomatitis and interleukin-1β genotype in a Polish cohort of patients.
    J Oral Pathol Med 2016 Dec 9. Epub 2016 Dec 9.
    Department of Oral Mucosa Diseases, University of Medical Sciences, Poznań, Poland.
    Background: The aim of this study was to evaluate the relation between a clinical profile and the interleukin-1β (IL-1β) genotype in a Polish cohort of patients with RAS.

    Methods: One hundred and four patients with RAS were enrolled in the study and all were subject to an oral examination. The severity of RAS was assessed according to the clinical type of the disease, the number of lesions per flare-up and the length of intervals between the episodes. Read More

    HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis.
    Iran J Allergy Asthma Immunol 2016 Aug;15(4):289-295
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Universal Scientific Education and Research Network (USERN), Tehran, Iran.
    Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. Read More

    Lack of Association between Interleukin-12 Gene Polymorphisms and Recurrent Aphthous Stomatitis.
    Avicenna J Med Biotechnol 2016 Oct-Dec;8(4):200-201
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA.

    Associations among oral health-related quality of life, subjective symptoms, clinical status, and self-rated oral health in Japanese university students: a cross-sectional study.
    BMC Oral Health 2016 Nov 30;16(1):127. Epub 2016 Nov 30.
    Departments of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
    Background: The present study aimed to elucidate the associations among self-rated oral health, clinical oral health status, oral health behaviors, subjective oral symptoms, and oral health-related quality of life (OHRQoL) in a group of Japanese university students.

    Methods: Of 2051 participants, 2027 (98.83%) students received an optional oral examination and answered a questionnaire including items regarding age, sex, self-rated oral health, oral health behaviors, subjective oral symptoms, and OHRQoL [The Oral Health Impact Profile (OHIP)-14]. Read More

    On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa.
    Oral Dis 2017 Apr 13;23(3):347-352. Epub 2017 Jan 13.
    Biomodels, LLC, Watertown, MA, USA.
    Objective: mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor-associated stomatitis (mIAS) a common, significant, dose-limiting toxicity, with aphthous-like lesions. Our objective was to assess the utility of a new organotypic model in defining mIAS' pathogenesis.

    Materials And Methods: The effect of everolimus on organotypic human oral mucosa was studied. Read More

    Crohn's disease should be considered in children with inflammatory oral lesions.
    Acta Paediatr 2017 Feb;106(2):199-203
    Department of Paediatric Dentistry, Medical University of Warsaw, Warsaw, Poland.
    This systematic review presents the oral manifestations of paediatric Crohn's disease. Our review of 28 papers published from 2000 to 2015 showed that the prevalence of oral manifestations was 10-80%. Specific symptoms included mucosal tags, swelling of the lips, cheeks and gingiva, and cobblestoning mucosa. Read More

    Is Optimal Management of Recurrent Aphthous Stomatitis Possible? A Reality Check.
    J Clin Diagn Res 2016 Oct 1;10(10):ZE08-ZE13. Epub 2016 Oct 1.
    Professor and Head of Department, Department of Oral Medicine and Radiology, The Oxford Dental College , Bengaluru, Karnataka, India .
    Recurrent Aphthous Stomatitis (RAS) is a condition in which aphthous ulcers repeatedly occur in the oral cavity. It is prevalent in developed countries, occurring in all ages, geographic regions and races and about 80% of people have one episode of oral aphthous ulcers before the age of 30 years. With no laboratory procedures to confirm the diagnosis, treatment is mainly empirical in nature and focuses on short-term symptomatic management. Read More

    Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis.
    Arch Oral Biol 2017 Feb 5;74:51-54. Epub 2016 Nov 5.
    Gaziosmanpasa University, Faculty of Dentistry, Department of Prosthodontics, Tokat, Turkey.
    Objectives: Recurrent aphthous stomatitis (RAS) is a common painful disorder affecting oral health, mucosa and overall quality of life. The etiopathogenesis of RAS remains unclear. RAS shows a large genetic diversity among the patients. Read More

    Low-level Laser Therapy: A Review of Its Applications in the Management of Oral Mucosal Disorders.
    Altern Ther Health Med 2016 Nov;22(6):24-31
    Due to its analgesic, anti-inflammatory, and biostimulating effects, low-level laser therapy (LLLT) has been widely used for oral disorders, such as oral lichen planus (OLP), xerostomia, recurrent aphthous stomatitis (RAS), herpes labialis, burning mouth syndrome (BMS), and oral mucositis (OM). The research team for the present study has reviewed the literature on the subject, with an emphasis on the applicability of LLLT in general and of its various clinical protocols for the management of those oral disorders. In lesions such as the ones occurring in OM, RAS, herpes labialis, and OLP, the course of wound healing and the pain have been shown to decrease, with a few, or most often, no adverse side effects. Read More

    Marshall syndrome in a young child, a reality: Case report.
    Medicine (Baltimore) 2016 Nov;95(44):e5065
    a"Sfanta Maria" Clinical Emergency Hospital for Childrenb"Grigore T. Popa" University of Medicine and Pharmacy, IasicEndocrinology Department of Clinical County Emergency Hospital, Cluj-NapocadENT Department of Arcadia Hospital, Iasi, Romania.
    Background: Recurrent fever syndrome, known as the Marshall syndrome (MS), is a clinical entity that includes several clinical features, such as: fever (39-40°C) that occurs repeatedly at variable intervals (3-8 weeks) and in episodes of 3 to 6 days, cervical adenopathy, pharyngitis, and aphthous stomatitis. The diagnosis of MS is one of exclusions; laboratory data is nonspecific and no abnormalities correlated with MS have been detected thus far.

    Methods: The authors report the case of a 2-year-old girl admitted to a tertiary pediatric center for repeated episodes of fever with aphthous stomatitis and laterocervical adenopathy. Read More

    Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis.
    J Formos Med Assoc 2016 Dec 7;115(12):1061-1068. Epub 2016 Nov 7.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Some of recurrent aphthous stomatitis (RAS) patients had concomitant atrophic glossitis (AG). This study assessed whether RAS patients with AG (AG+/RAS patients) or without AG (AG-/RAS patients) had anemia and hematinic deficiencies and to evaluate whether RAS combined with AG or RAS itself was a significant factor causing anemia and hematinic deficiencies in AG+/RAS or AG-/RAS patients, respectively.

    Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 160 AG+/RAS patients, 195 AG-/RAS patients, and 355 healthy control subjects. Read More

    [Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].
    Hautarzt 2016 Dec;67(12):940-947
    Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.
    Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

    Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

    Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

    Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive or all autoantibodies-negative recurrent aphthous stomatitis patients.
    J Formos Med Assoc 2017 Feb 5;116(2):99-106. Epub 2016 Nov 5.
    School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs-/RAS) patients.

    Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs-/RAS patients, and 342 healthy control subjects. Read More

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