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    Analysis of Dietary Related Factors of Recurrent Aphthous Stomatitis among College Students.
    Evid Based Complement Alternat Med 2018 27;2018:2907812. Epub 2018 Feb 27.
    Wenzhou Traditional Chinese Medicine Hospital, Zhejiang 325000, China.
    Objective: We investigated the occurrence of recurrent aphthous stomatitis (RAS) among college students and its potential influence by dietary habits.

    Methods: Study of dietary habits and RAS among students in Beijing University of Chinese Medicine was carried by homemade questionnaire. Multivariate binary logistic regression analysis was used to identify RAS risk factors and explore their relations. Read More

    An international delphi survey for the definition of the variables for the development of new classification criteria for periodic fever aphtous stomatitis pharingitis cervical adenitis (PFAPA).
    Pediatr Rheumatol Online J 2018 Apr 18;16(1):27. Epub 2018 Apr 18.
    Unité Romande d'Immuno-rhumatologie Pédiatrique, CHUV, University of Lausanne, Lausanne, and HUG, Geneva, Switzerland.
    Background: Diagnosis of Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) is currently based on a set of criteria proposed in 1999 modified from Marshall's criteria. Nevertheless no validated evidence based set of classification criteria for PFAPA has been established so far. The aim of this study was to identify candidate classification criteria PFAPA syndrome using international consensus formation through a Delphi questionnaire survey. Read More

    Extraintestinal Manifestations in Vedolizumab and Anti-TNF-Treated Patients With Inflammatory Bowel Disease.
    Inflamm Bowel Dis 2018 Apr 13. Epub 2018 Apr 13.
    AbbVie Inc., North Chicago, Illinois.
    Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies.

    Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016. Read More

    Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis.
    J Formos Med Assoc 2018 Apr 10. Epub 2018 Apr 10.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AGRAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients.

    Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AGRAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Read More

    The association between minor recurrent aphthous stomatitis (RAS), children's poor oral condition, and underlying negative psychosocial habits and attitudes towards oral hygiene.
    BMC Pediatr 2018 Apr 13;18(1):136. Epub 2018 Apr 13.
    Dental School, Vita-Salute San Raffaele University and IRCCS San Raffaele, Via Olgettina 58, I-20132, Milan, Italy.
    Background: Minor Recurrent Aphthous Stomatitis (RAS) represents a disease which is very difficult to prevent. This case-control study focused on possible associations between minor Recurrent Aphthous Stomatitis in children, their oral health, and underlying behavioral indexes of children's attitudes and habits pertaining to (home) oral hygiene, with the further goal of enabling the dentist to prevent these specific kind of lesions, both from a clinical and a broader psychosocial perspective.

    Methods: Four hundred one school-children (5-10 years old) in Milan (Italy) were submitted to an intra-oral examination, and interviewed with the aid of a brief psychosocial questionnaire. Read More

    Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis.
    Genet Test Mol Biomarkers 2018 Apr 12;22(4):237-245. Epub 2018 Mar 12.
    1 Department of Orthodontics, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School & Hospital of Stomatology, Tongji University , Shanghai, China .
    Aim: To determine if there are significant associations between polymorphisms of the IL-1, IL-6, and IL-10 genes and susceptibility to recurrent aphthous stomatitis (RAS).

    Methods: The PubMed, Embase, and Web of Science databases were searched for all eligible studies using both medical subheadings and free terms through December 2016. A total of 226 citations were retrieved. Read More

    Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis.
    Carbohydr Polym 2018 Jun 6;190:339-345. Epub 2018 Mar 6.
    Pharmacy Department, Federal University of Sergipe, São Cristóvão, SE, Brazil. Electronic address:
    Mucoadhesive membranes were proposed in this study as drug delivery system for betamethasone-17-valerate (BMV) in the treatment of recurrent aphthous stomatitis (RAS). The membranes were obtained by using the polymers chitosan (CHI) in both presence and absence of polyvinilpyrrolidone (PVP), following the solvent evaporation method. The presence of PVP in the membranes causes significant modifications in its thermal properties. Read More

    Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis.
    J Formos Med Assoc 2018 Mar 20. Epub 2018 Mar 20.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AGRAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects.

    Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AGRAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects. Read More

    Treatment of severe generalized chronic periodontitis in a patient with Behçet's disease: A case report.
    J Int Med Res 2018 Jan 1:300060518762267. Epub 2018 Jan 1.
    Department of Dentistry and Oral Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.
    Behçet's disease is a systemic disorder of unknown etiology. It involves multiple organ systems and is characterized by recurring episodes of oral ulcers as well as ocular, genital, and skin lesions. Oral ulcers can affect tooth brushing and impair proper oral hygiene. Read More

    Association between interleukin family gene polymorphisms and recurrent aphthous stomatitis risk.
    Genes Immun 2018 Mar 18. Epub 2018 Mar 18.
    Department of Clinical Laboratory, Longquanyi District of Chengdu Maternity and Child Health Care Hospital, Chengdu, 610100, Sichuan Province, China.
    The present study was aimed at identifying the association between interleukin family gene polymorphisms and recurrent aphthous stomatitis (RAS) risk using a meta-analysis. We searched the PubMed, web of science, Embase and ScienceDirect-Elsevier databases for research on the interleukin polymorphism and RAS risk. In total 12 studies were included to investigate the relationships between RAS risk and six polymorphisms by calculating pooled odds ratios (ORs) and 95% confidence intervals (CIs). Read More

    Gastric parietal cell and thyroid autoantibodies in patients with Behcet's disease.
    J Formos Med Assoc 2018 Mar 14. Epub 2018 Mar 14.
    Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan. Electronic address:
    Background/purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) were rarely examined in Behcet's disease (BD) patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients.

    Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 63 BD patients, 19 major-typed recurrent aphthous stomatitis (RAS)/BD (major RAS/BD) patients, 44 minor-typed RAS/BD (minor RAS/BD) patients, 520 RAS patients, and 126 healthy control subjects were calculated and compared. Read More

    Comorbidity of PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) patients: a case control study.
    Clin Exp Rheumatol 2018 Feb 27. Epub 2018 Feb 27.
    PEDEGO Research Unit, Medical Research Centre, University of Oulu; Tampere Centre for Child Health Research, University of Tampere; and Department of Children and Adolescents, Tampere University Hospital, Finland.
    Objectives: To compare the long-term morbidity of patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome treated by tonsillectomy (TE) in childhood to that of matched controls.

    Methods: We identified 132 PFAPA patients from the medical records treated by TE in 1987-2007 in Oulu University Hospital, Finland. Altogether 119 patients participated the follow-up study and 94 were clinically examined on average 9. Read More

    Relationship between salivary calprotectin levels and recurrent aphthous stomatitis: A preliminary study.
    Niger J Clin Pract 2018 Mar;21(3):271-275
    Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul University, Capa, Fatih, Istanbul, Turkey.
    Aim: Recurrent aphthous stomatitis (RAS) is an inflammatory condition of the oral mucosa. The etiology of RAS remains unclear. Calprotectin is a major cytoplasmic protein contained in granulocytes, monocytes/macrophages and epithelial cells, and its level is increased body fluids in some inflammatory diseases. Read More

    Familial Mediterranean fever mimicking Crohn disease: A case report.
    Medicine (Baltimore) 2018 Jan;97(1):e9547
    Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University.
    Rationale: Familial Mediterranean fever (FMF) is the most common form of autoinflammatory disease. We report a rare case of FMF with gastrointestinal lesions mimicking Crohn disease.

    Patient Concerns: A 21-year-old Japanese man was referred to our institution, complaining of refractory diarrhea and weight loss of 14 kg during the past two years. Read More

    Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (RAS).
    J Oral Pathol Med 2018 Mar 2. Epub 2018 Mar 2.
    Department of Oral Mucosa Diseases, University of Medical Sciences, Poznań, Poland.
    Background: Recurrent aphthous stomatitis is a common ulcerative disorder of the oral mucosa, where the immune impairment may develop in genetically predisposed subjects exposed to certain environmental factors. The aim of the study was to investigate the frequency of anaemia, iron and vitamin B12 deficiency in recurrent aphthous stomatitis (RAS) and to explore its impact on the clinical presentation of RAS.

    Methods: A total of 141 adults including the following: 71 subjects with RAS and 70 controls were enrolled in the study. Read More

    The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review.
    BMC Ear Nose Throat Disord 2018 22;18. Epub 2018 Feb 22.
    1Department of Paediatrics, Stavanger University Hospital, PO BOX 8100, 4068 Stavanger, Norway.
    Background: Tonsillectomy (TE) or adenotonsillectomy (ATE) may have a beneficial effect on the clinical course in children with the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome. However, an immunological reason for this effect remains unknown. This literature review summarizes the current knowledge of the effect of TE or ATE in the PFAPA syndrome. Read More

    Hematinic deficiencies in patients with recurrent aphthous stomatitis: variations by gender and age.
    Med Oral Patol Oral Cir Bucal 2018 Mar 1;23(2):e161-e167. Epub 2018 Mar 1.
    Department of Gastroenterology and Hepatology, The First Clinical Hospital of Shanxi Medical University, Mailbox 427, 85 Jiefang South Road, Taiyuan, Shanxi Province, China 030001,
    Background: The aim of this study was to evaluate the association between hematinic deficiencies and recurrent aphthous stomatitis (RAS).

    Material And Methods: 517 RAS patients and 187 healthy controls were enrolled in the present study. Hematinic deficiencies, including serum ferritin, folic acid, and vitamin B12 deficiencies were assessed for each participant. Read More

    How social media meet patients’ questions: YouTube™ review for mouth sores in children.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):117-121
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    Recurrent aphthous stomatitis (RAS) is one of the most common causes of mouth sores in children so the management of this condition is a matter of great importance. YouTube™ is increasingly being used by patients to obtain health-related information. The aim of this work is to examine the quality of information offered by YouTube™ about mouth sores in children (MSC). Read More

    Autosomal dominant deficiency of the interleukin-17F in recurrent aphthous stomatitis: Possible novel mutation in a new entity.
    Gene 2018 May 16;654:64-68. Epub 2018 Feb 16.
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    Recurrent Aphthous Stomatitis (RAS) is a common oral inflammatory disease with unknown pathogenesis. Although the immune system alterations could be involved in predisposition of individuals to oral candidiasis, precise etiologies of RAS have not been understood yet. A recent study showed that autosomal dominant IL17F deficiency could cause chronic mucocutaneous candidiasis. Read More

    Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center.
    World J Clin Pediatr 2018 Feb 8;7(1):49-55. Epub 2018 Feb 8.
    Department of Medicine, Surgery and Health, University of Trieste, Trieste 34142, Italy.
    Aim: To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever (UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.

    Methods: Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever (HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis (PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: (NM_000243. Read More

    Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report.
    Open Dent J 2018 29;12:19-23. Epub 2018 Jan 29.
    Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, SP. Brazil.
    Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman.

    Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. Read More

    Stomatitis associated with mammalian target of rapamycin inhibition: A review of pathogenesis, prevention, treatment, and clinical implications for oral practice in metastatic breast cancer.
    J Am Dent Assoc 2018 Apr 10;149(4):291-298. Epub 2018 Feb 10.
    Background: Patients with metastatic breast cancer may develop oral morbidities that result from therapeutic interventions. Mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis (mIAS) is a common adverse event (AE), secondary to mTOR inhibitor therapy, that can have a negative impact on treatment adherence, quality of life, and health care costs. A multidisciplinary team approach is important to minimize mIAS and to maximize treatment benefits to patients with breast cancer. Read More

    CD70 Deficiency due to a Novel Mutation in a Patient with Severe Chronic EBV Infection Presenting As a Periodic Fever.
    Front Immunol 2017 29;8:2015. Epub 2018 Jan 29.
    Clinica Pediatria e Reumatologia, Istituto Giannina Gaslini, Genova, Italy.
    Primary immunodeficiencies with selective susceptibility to EBV infection are rare conditions associated with severe lymphoproliferation. We followed a patient, son of consanguineous parents, referred to our center for recurrent periodic episodes of fever associated with tonsillitis and adenitis started after an infectious mononucleosis and responsive to oral steroid. An initial diagnosis of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome was done. Read More

    Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population.
    J Oral Pathol Med 2018 Apr 2;47(4):434-439. Epub 2018 Mar 2.
    Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymorphisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population.

    Methods: A total of 207 subjects were included in this case-control study. Read More

    Vitamin D status in recurrent aphthous stomatitis.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):612-617. Epub 2017 Dec 31.
    Department of Oral Mucosa Diseases, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease.

    Aim: To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism. Read More

    Association of IL-6-174 G/C and IL10-1082 G/A polymorphisms with recurrent aphthous stomatitis risk: A meta-analysis.
    Medicine (Baltimore) 2017 Dec;96(52):e9533
    Institute of Stomatology, Chinese PLA General Hospital, Beijing, China.
    Background: Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown etiology. The association between IL-6-174 G/C and IL10-1082 G/A polymorphisms and the risk of RAS remains controversial. Therefore, we conducted this meta-analysis to gain more evidence-based information. Read More

    Systemic bioinformatics analysis of recurrent aphthous stomatitis gene expression profiles.
    Oncotarget 2017 Dec 10;8(67):111064-111072. Epub 2017 Nov 10.
    Department of Laboratory Medicine, The First People's Hospital of Yancheng City, Yancheng 224006, Jiangsu, China.
    Recurrent aphthous stomatitis (RAS) represents the most common chronic oral diseases with the prevalence ranges from 5% to 25% for different populations. Its pathogenesis remains poorly understood, which limits the development of effective drugs and treatment methods. In this study, we conducted systemic bioinformatics analysis of gene expression profiles from the Gene Expression Omnibus (GEO) to identify potential drug targets for RAS. Read More

    Examination of serum hematinics and autoantibodies is important for treatment of recurrent aphthous stomatitis.
    J Formos Med Assoc 2018 Apr 12;117(4):258-260. Epub 2018 Jan 12.
    Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

    The role of colchicine in the treatment of autoinflammatory diseases.
    Curr Pharm Des 2018 Jan 15. Epub 2018 Jan 15.
    Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens. Greece.
    Colchicine has been longstanding and widely used for the treatment of acute gout flares and prevention of gout relapses. Its use has been extended to a series of autoinflammatory diseases, such as familial Mediterranean fever and more recently to periodic fever with aphthous stomatitis, pharyngitis and adenitis, Behcet's disease and idiopathic recurrent acute pericarditis. In this review, we summarize current indications of colchicine use, discuss its pharmacokinetics and mechanism of action and examine its use in the treatment of autoinflammatory diseases. Read More

    Healthy lifestyle habits benefit remission of recurrent aphthous stomatitis and RAS type ulceration.
    Br Dent J 2018 Jan 12;224(2):70-71. Epub 2018 Jan 12.
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China School of Stomatology, Sichuan University Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University.
    In a clinical setting, it is not practical to separate recurrent aphthous stomatitis (RAS) from RAS-type ulceration in every case, so both conditions have been considered together for the purpose of this article. Due to the lack of consistently effective therapeutic options for RAS, other approaches to treat the disease are considered here, beginning with an analysis of possible aetiological factors. The aetiology of RAS, the most common mucosal disease, remains undefined thus far. Read More

    Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis.
    Acta Med Iran 2017 Nov;55(11):672-675
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
    This study has been conducted to evaluate the allele, genotype and haplotype frequencies of the polymorphic gene coding TGF-β in recurrent aphthous stomatitis (RAS). TGF-β gene typing was done by polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. Allele frequencies were estimated by direct gene counting. Read More

    Association of Serotonin Transporter Gene Polymorphism with Recurrent Aphthous Stomatitis.
    Avicenna J Med Biotechnol 2018 Jan-Mar;10(1):56-60
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Recurrent Aphthous Stomatitis (RAS) is one of the most common diseases of the oral cavity all over the world (5-66%). RAS has a multifactorial etiology, while psychological factors such as stress and anger play a role in its manifestation. The serotonergic mechanisms particularly the serotonin-transporter gene () may affect the risk of psychological alterations and stress response. Read More

    Psychological factors in oral mucosal and orofacial pain conditions.
    Eur J Dent 2017 Oct-Dec;11(4):548-552
    Department of Oral Medicine and Oral Surgery, Faculty of Dentistry,University of Science and Technology, Irbid, Jordan.
    The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions (namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders) with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients. A literature search restricted to reports with highest relevance to the selected mucosal and orofacial pain conditions was carried out to retrieve data. Read More

    A case of adult-onset periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome in Japan.
    J Gen Fam Med 2017 Oct 2;18(5):261-264. Epub 2017 May 2.
    Department of Internal MedicineNagano Chuo HospitalNaganoJapan.
    Adult-onset periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is rare. We report the case of a 23-year-old woman with PFAPA syndrome in Japan. Her symptoms lasted for approximately 5 days in each period regardless of nonsteroidal anti-inflammatory drug or antibiotic treatment. Read More

    Evaluation of serum zinc levels in patients with recurrent aphthous stomatitis (RAS).
    BMC Oral Health 2017 Dec 20;17(1):158. Epub 2017 Dec 20.
    Department of Gerodontology and Oral Pathology, University of Medical Sciences, ul. Bukowska 70, 60-812, Poznań, Poland.
    Background: Recurrent aphthous stomatitis (RAS) is an ulcerative disease of the oral mucosa without a clearly defined etiology. The aim of the study was to evaluate the serum zinc levels in patients with RAS in comparison to healthy controls and to validate the association between zinc levels and the course of RAS.

    Methods: Seventy-five patients with RAS and 72 controls underwent full dental examination. Read More

    Relative Efficacy of Quercetin Compared with Benzydamine Hydrochloride in Minor Aphthae: A Prospective, Parallel, Double Blind, Active Control, Preliminary Study.
    Int J Dent 2017 13;2017:7034390. Epub 2017 Nov 13.
    Oral Medicine and Radiology, A. J. Institute of Dental Sciences, Mangalore, India.
    Background And Objectives: Recurrent aphthous stomatitis is an inflammatory condition present since ancient era wherein numerous treatment modalities have been tried. But complete eradication of the disease has not been possible and hence newer agents are being introduced. One such agent is a flavonoid named quercetin with proven antioxidant, anti-inflammatory, and ulcer healing properties. Read More

    Miscellaneous skin disease and the metabolic syndrome.
    Clin Dermatol 2018 Jan - Feb;36(1):94-100. Epub 2017 Sep 8.
    Department of Dermatology, Istanbul Medeniyet University, Medical School, Istanbul, Turkey. Electronic address:
    The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. Read More

    Oral Manifestations in Pediatric Patients with Coeliac Disease - A Review Article.
    Open Dent J 2017 24;11:539-545. Epub 2017 Oct 24.
    Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University, of Porto, Porto, Portugal.
    Background: Coeliac disease is a chronic enteropathy that remains a challenge for the clinician, due to its atypical manifestations and etiopathogenic complexity.

    Objective: This article intends to describe the oral characteristics of Coeliac Disease in children in order to facilitate their management in the dental office.

    Methods: A review of the literature was performed electronically in PubMed (PubMed Central, and MEDLINE) for articles published in English from 2000 to April of 2017. Read More

    Characteristics and Disease Course in a Cohort of Children With PFAPA Syndrome in the Community of Madrid, Spain.
    Reumatol Clin 2017 Dec 8. Epub 2017 Dec 8.
    Servicio de Enfermedades Infecciosas Pediátricas, Hospital General Universitario Gregorio Marañón, Madrid, España.
    Introduction: PFAPA syndrome is an autoinflammatory disease whose diagnosis is mainly clinical. Several treatments have been proposed; among them, tonsillectomy could be an effective one.

    Material And Methods: Retrospective multicenter study. Read More

    A Clinical and Microbiological Evaluation of Helicobacter pylori in Recurrent Aphthous Stomatitis.
    J Contemp Dent Pract 2017 Dec 1;18(12):1194-1197. Epub 2017 Dec 1.
    Department of Public Health Dentistry, Institute of Dental Education & Advance Studies (IDEAS), Gwalior, Madhya Pradesh, India.
    Aim: The aim of this study is to evaluate the association of Helicobacter pylori in recurrent aphthous stomatitis (RAS) with or without peptic ulcer.

    Materials And Methods: A total of 42 patients were selected for the present study from outpatient Department of Oral Medicine, and divided into control (group I) and test groups (groups II, III). A total number of 15 patients suffering from RAS based on history and clinical examination was selected as group II. Read More

    Recurrent Aphthous Stomatitis: An Assessment of Antioxidant Levels in Plasma and Saliva.
    J Clin Diagn Res 2017 Sep 1;11(9):ZC64-ZC67. Epub 2017 Sep 1.
    Manager, Department of Development Office, Christian Medical College, Vellore, Tamil Nadu, India.
    Introduction: Recurrent Aphthous Stomatitis (RAS) is a common oral mucosal disorder that affects 20% of the population worldwide. Factors such as trauma, stress, genetic, hypersensitivity, nutrition, immune disturbance and hormonal imbalance may disturb the oxidant and antioxidant balance of an organism and precipitate RAS, but the relationships are poorly understood.

    Aim: The purpose of this study was to evaluate the antioxidant status in plasma and saliva of patients with RAS. Read More

    Tooth Wear Is Frequent in Adult Patients with Celiac Disease.
    Nutrients 2017 Dec 4;9(12). Epub 2017 Dec 4.
    Department of Medicine, Surgery and Dentistry, Medical School of Salerno, 84131 Salerno, Italy.
    (1) Background: Celiac disease (CD) patients can be affected by mouth and tooth disorders, which are influenced by their gluten-free diet. The aim of our research was to evaluate the pathological conditions of the stomatognathic system observed in celiac patients on a gluten-free diet. (2) Methods: we consecutively recruited celiac patients on a gluten-free diet at our celiac center, as well as healthy volunteers. Read More

    Long-term follow-up of tonsillectomy efficacy in children with PFAPA syndrome.
    Braz J Otorhinolaryngol 2017 Nov 21. Epub 2017 Nov 21.
    Umraniye Training and Research Hospital, Department of Otolaryngology, Istanbul, Turkey.
    Introduction: The role of tonsillectomy in the periodic fever, aphthous stomatitis, pharyngitis, and adenitis, PFAPA syndrome, is controversial. Although some studies reported high success rates with tonsillectomy, further investigations are needed with larger numbers of patients.

    Objective: To seek the long-term outcomes of tonsillectomy in PFAPA syndrome. Read More

    Clinical evaluation of a toothpaste containing lysozyme for the treatment of recurrent aphthous stomatitis: A 3-month, double-blind, randomized study.
    Am J Dent 2016 Dec;29(6):303-306
    Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
    Purpose: To assess the efficacy and safety of a toothpaste containing lysozyme for the treatment of minor recurrent aphthous stomatitis (MiRAS) in a 3-month clinical trial.

    Methods: 71 participants with MiRAS were recruited to this randomized, parallel-controlled, double-blind clinical trial. Participants were allocated randomly to the test group or the control group. Read More

    Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study.
    An Bras Dermatol 2017 Sep-Oct;92(5):626-629
    Post-Graduation Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL)- Pelotas (RS), Brazil.
    Background: Recurrent aphthous stomatitis is a painful disorder of unknown etiology. It is among the most common oral mucosal lesions with high prevalence among young adults.

    Objectives: To conduct a population-based study with 18-year-old army recruiters to assess its prevalence and associated factors in male adolescents. Read More

    Exacerbation of Behçet's syndrome and familial Mediterranean fever with menstruation.
    Clin Exp Rheumatol 2017 Nov-Dec;35 Suppl 108(6):95-99. Epub 2017 Oct 24.
    Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Turkey.
    Obectives: Menstruation triggers several conditions such as migraine, recurrent aphthous stomatitis and acne vulgaris in healthy individuals. There is evidence that Behçet's syndrome (BS) and familial Mediterranean fever (FMF) may exacerbate during menstruation. The aim is to assess whether BS and FMF patients experience menstrual flares. Read More

    A Dramatic Case of Odynophagia.
    Dysphagia 2018 Feb 11;33(1):133-135. Epub 2017 Nov 11.
    Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
    We report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. The severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ENT, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). During this time, the patient received central parenteral nutrition with an episode of catheter-related septicemia, and he came to require psychiatric assistance for autolytic ideation. Read More

    Atypical Afta Major Healing after Photodynamic Therapy.
    Case Rep Dent 2017 20;2017:8517470. Epub 2017 Sep 20.
    Diabetology, San Michele Hospital, Cagliari, Italy.
    The aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity clinical examination showed several major symptomatic ulcers, previously treated with topical and systemic therapies without any benefit. Read More

    Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design.
    Adv Pharm Bull 2017 Sep 25;7(3):441-450. Epub 2017 Sep 25.
    Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
    Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Read More

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