19,676 results match your criteria Aphasia

Haploinsufficiency of PRRT2 Leading to Familial Hemiplegic Migraine in Chromosome 16p11.2 Deletion Syndrome.

Neuropediatrics 2022 May 26. Epub 2022 May 26.

Neurology, Children's National Health System, Washington, United States.

Microdeletion in the 16p11.2 loci lead to a distinct neurodevelopmental disorder with intellectual disability and autism spectrum disorder in addition to dysmorphia, macrocephaly and increased body mass index (BMI). One of the deleted genes in this region is PRRT2 which codes for Proline-rich transmembrane protein 2. Read More

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Ictal paraphasia as an atypical manifestation of temporal lobe epilepsy.

Neurocase 2022 May 24:1-4. Epub 2022 May 24.

Neurologist- Epileptologist, Hospital Universitario Fundación Santa Fe de Bogotá.

Language disturbances are common manifestations of non-convulsive seizures in focal epilepsy. Ictal aphasia and speech arrest are the most representative. On the other hand, ictal paraphasia is a rare clinical manifestation of dominant temporal lobe epilepsy, with few cases reported in the literature. Read More

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Applying linguistic demand analysis to functional multitasking assessments.

Appl Neuropsychol Adult 2022 May 24:1-10. Epub 2022 May 24.

Nova Southeastern University, Ft. Lauderdale, FL, USA.

Purpose: The linguistic demand of task instructions in cognitive assessments may mask or even invalidate cognitive testing results for individuals with language differences or impairments. The purpose of this study was to apply an analysis of linguistic demand to a sample of functional multitasking assessments.

Method: We sampled the task instructions and materials from seven functional multitasking assessments that are based on everyday activities. Read More

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Efficacy of repetitive transcranial magnetic stimulation in treating stroke aphasia: Systematic review and meta-analysis.

Clin Neurophysiol 2022 May 5. Epub 2022 May 5.

Department of Psychology, University of Arizona, AZ, USA.

Objective: This meta-analysis examined the effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) in treating post-stroke aphasia with a goal to identify parameters that are associated with successful treatment outcomes.

Methods: Following PRISMA guidelines, ten electronic databases were searched from inception till June 4th 2020. A total of 24 studies (out of 1971 records) with 567 participants met selection criteria and were included in the meta-analysis. Read More

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Transcranial Direct Current Stimulation Paired With Verb Network Strengthening Treatment Improves Verb Naming in Primary Progressive Aphasia: A Case Series.

Am J Speech Lang Pathol 2022 May 23:1-19. Epub 2022 May 23.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: There are few evidence-based treatments for language deficits in primary progressive aphasia (PPA). PPA treatments are often adopted from the poststroke aphasia literature. The poststroke aphasia literature has shown promising results using Verb Network Strengthening Treatment (VNeST), a behavioral therapy that focuses on improving naming by producing verbs and their arguments in phrases and sentences. Read More

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The efficacy of a directed rhythmic-melodic voice training in the treatment of chronic non-fluent aphasia-Behavioral and imaging results.

J Neurol 2022 May 23. Epub 2022 May 23.

Clinical Cognition Research, University Hospital Aachen, RWTH, Aachen, Germany.

The main objective of this study was to investigate the efficacy of a directed rhythmic-melodic voice training (SIPARI) compared to language therapy with the focus on improvement in expressive linguistic performance. 20 patients suffering from chronic non-fluent aphasia, allocated by coin tossing to either of the groups, participated in 32 single therapy sessions over a period of 4 months. Before and after therapy, independent testers performed a standardized language test (Aachener Aphasie Test). Read More

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Understanding, facilitating and predicting aphasia recovery after rehabilitation.

Int J Speech Lang Pathol 2022 May 23:1-12. Epub 2022 May 23.

Aphasia Research Laboratory, Department of Speech, Language & Hearing Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA, USA.

This paper reviews several studies whose aim was to understand the nature of language recovery in chronic aphasia and identify predictors of how people may recover their language functions after a brain injury. Several studies that mostly draw from data collected within the Centre for Neurobiology of Language Recovery were reviewed and categorised in four aspects of language impairment and recovery in aphasia: (a) neural markers for language impairment and recovery, (b) language and cognitive markers for language impairment and recovery, (c) effective treatments and (d) predictive modelling of treatment-induced rehabilitation. Language impairment and recovery in stroke-induced aphasia is multi-factorial, including patient-specific and treatment-specific factors. Read More

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Assessing executive functions in post-stroke aphasia-utility of verbally based tests.

Brain Commun 2022 26;4(3):fcac107. Epub 2022 Apr 26.

MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge CB2 7EF, United Kingdom.

It is increasingly acknowledged that, often, patients with post-stroke aphasia not only have language impairments but also deficits in other cognitive domains (e.g. executive functions) that influence recovery and response to therapy. Read More

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Rigorous Qualitative Research Involving Data Collected Remotely From People With Communication Disorders: Experience From a Telerehabilitation Trial.

Neurorehabil Neural Repair 2022 May 21:15459683221100489. Epub 2022 May 21.

Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, 198734Université de Sherbrooke, Longueuil, QC, Canada.

Diverse challenges arise with research involving people with communication disorders while using remote methods for data collection. Ethical and methodological issues related to the inclusion of people with communication disorders in research, specifically qualitative research, are magnified by communication challenges specific to remote communication. Avenues are discussed to ensure that remote data collection processes can include people with a communication disorder, while limiting negative impacts on the validity of the data. Read More

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Dissociable language and executive control deficits and recovery in post-stroke aphasia: An exploratory observational and case series study.

Neuropsychologia 2022 May 18:108270. Epub 2022 May 18.

Department of Neurology, USA; Physical Medicine and Rehabilitation, USA; Cognitive Science, Johns Hopkins University, Baltimore, MD, USA.

A growing body of evidence indicates many, but not all, individuals with post-stroke aphasia experience executive dysfunction. Relationships between language and executive function skills are often reported in the literature, but the degree of interdependence between these abilities remains largely unanswered. Therefore, in this study, we investigated the extent to which language and executive control deficits dissociated in 1) acute stroke and 2) longitudinal aphasia recovery. Read More

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Diffusion tractography of superior cerebellar peduncle and dentatorubrothalamic tracts in two autopsy confirmed progressive supranuclear palsy variants: Richardson syndrome and the speech-language variant.

Neuroimage Clin 2022 May 11;35:103030. Epub 2022 May 11.

Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy with neurodegeneration typically observed in the superior cerebellar peduncle (SCP) and dentatorubrothalamic tracts (DRTT). However, it is unclear how these tracts are differentially affected in different clinical variants of PSP.

Objectives: To determine whether diffusion tractography of the SCP and DRTT can differentiate autopsy-confirmed PSP with Richardson's syndrome (PSP-RS) and PSP with predominant speech/language disorder (PSP-SL). Read More

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Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration.

Mol Psychiatry 2022 May 20. Epub 2022 May 20.

Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in frontotemporal lobar degeneration (FTLD). Eighty FTLD patients (including cases with behavioral variant of frontotemporal dementia, primary progressive aphasia, progressive supranuclear palsy syndrome, motor neuron disease) and 65 healthy controls underwent rs-functional MRI. Emotion processing was tested using the Comprehensive Affect Testing System (CATS). Read More

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'Regarding the scientific viewpoint in psychiatry', lecture by Carl Wernicke (1880).

Hist Psychiatry 2022 06;33(2):236-255

Vanderbilt University Medical Center, Nashville, USA.

In 1880 Carl Wernicke gave this plenary lecture at an annual meeting of German physicians and natural scientists. He used principles from his 1874 aphasia monograph to build a neural model of mental illness. He proposed that the brain keeps a record of experiences in distinct areas of the sensory and motor cortices in the form of memory images, which allows for recognition of objects and the planning of motor acts. Read More

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Meta-synthesis of family communication patterns during post-stroke vascular aphasia: Evidence to guide practice.

Worldviews Evid Based Nurs 2022 May 19. Epub 2022 May 19.

Public Health, University of Livingstonia, Mzuzu, Malawi.

Background: Previous studies have predominantly focused on the needs of persons with aphasia (PWA), after a stroke diagnosis. However, aphasia is found to cause communication challenges in persons with stroke and their family caregivers as a unit. Evidence is inconclusive about the communication patterns of both persons with aphasia and their family caregivers after a stroke. Read More

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Sensitivity of the Social Behavior Observer Checklist to Early Symptoms of Patients With Frontotemporal Dementia.

Neurology 2022 May 18. Epub 2022 May 18.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.

Background And Objectives: Changes in social behavior are common symptoms of frontotemporal lobar degeneration (FTLD) and Alzheimer's disease syndromes. For early identification of individual patients and differential diagnosis, sensitive clinical measures are required that are able to assess patterns of behaviors and detect syndromic differences in both asymptomatic and symptomatic stages. We investigated whether the examiner-based Social Behavior Observer Checklist (SBOCL) is sensitive to early behavior changes and reflects disease severity within and between neurodegenerative syndromes. Read More

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Nineteenth- and twentieth-century brain maps relating to locations and constructions of brain functions.

J Wayne Lazar

J Hist Neurosci 2022 May 18:1-26. Epub 2022 May 18.

Neurospychologist (Retired), New York, New York, USA.

This article is an outline of the transition in "brain maps" used to illustrate locations of cortical "centers" associated with movements, sensations, and language beginning with images from Gall and Spurzheim in the nineteenth century through those of functional magnetic resonance imaging in the twenty-first century. During the intervening years, new approaches required new brain maps to illustrate them, and brain maps helped to objectify and naturalize mental processes. One approach, electrical stimulation of the cerebral cortex-exemplified by Fritsch and Hitzig in 1870, Ferrier in 1873, and Penfield by 1937-required brain maps showing functional centers with expanded and overlapping boundaries. Read More

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The FAST VAN for Field Identification of Large Vessel Occlusion in Acute Stroke.

Can J Neurol Sci 2022 May 18:1-4. Epub 2022 May 18.

Division of Neurology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Background: There is definitive evidence for effectiveness of thrombectomy for acute stroke with large vessel occlusion (LVO). A clinical tool to identify patients with LVO is therefore required for effective triage and prehospital decision making. We developed the FAST VAN tool, which follows from the Heart and Stroke Foundation FAST stroke screen, with the addition of cortical features of vision, aphasia, and neglect, to differentiate from lacunar syndromes. Read More

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Noninvasive stimulation of the unlesioned hemisphere and phonological treatment in a case of chronic anomia post-stroke.

Neurocase 2022 May 17:1-12. Epub 2022 May 17.

Neuroscience Division, Noninvasive Neurostimulation Laboratory, Research Center of CHU de Québec - Université Laval, Québec, Canada.

Chronic lexical anomia after left hemisphere (LH) stroke improves under personalized phonological treatment (PT). Cortical linking between language and hand motor areas (hand_M1) questioned whether PT-related improvement relies on the unlesioned hemisphere (UH) plasticity when LH is dysfunctional. Our 70-yo-woman case study showed that 10 sessions of excitatory stimulation of UH_hand-M1 combined with PT hastened oral picture naming improvement as compared to sham+PT and changes were maintained together with changes of untrained items andcorticomotor excitability increase. Read More

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Applying Appraisal Tools in Aphasia Systematic Reviews: A Tutorial.

Am J Speech Lang Pathol 2022 May 17:1-10. Epub 2022 May 17.

Old Dominion University, Norfolk, VA.

Purpose: A systematic review (SR) represents a rigorous process of identifying and summarizing current research to answer specific clinical questions. Not all SRs present high-quality information, because they do not adhere to established standards of conduct or reporting. This tutorial aims to (a) describe two tools developed in epidemiology for reporting (PRISMA 2020; Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and appraising (AMSTAR 2; A MeaSurement Tool to Assess Systematic Reviews) SRs and (b) exemplify the use of AMSTAR 2. Read More

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Carotid micromesh stent for the cervical carotid artery dissecting aneurysm in a patient with vascular Eagle syndrome.

J Stroke Cerebrovasc Dis 2022 May 13;31(8):106487. Epub 2022 May 13.

Department of Neurosurgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka 530-8480, Japan.

Objectives: An elongated styloid process may cause vascular Eagle syndrome that includes cervical carotid artery (CCA) dissection with stenosis and aneurysm formation. There are only four reported cases with vascular Eagle syndrome-related CCA dissecting aneurysm treated with carotid artery stenting (CAS). This is the first report of applying a dual-layer nitinol micromesh stent (CASPER) for vascular Eagle syndrome-related CCA dissecting aneurysm. Read More

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Transient Ischemic Attack Secondary to Device-Related Thrombus After Left Atrial Appendage Closure.

Cureus 2022 Apr 12;14(4):e24073. Epub 2022 Apr 12.

Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, USA.

The patient is an 84-year-old female with a significant past medical history of traumatic subarachnoid hemorrhage, bleeding peptic ulcer disease, permanent atrial fibrillation status post percutaneous left atrial appendage closure (LAAC) initially admitted to the hospital secondary to expressive aphasia. The patient was found to have a transient ischemic attack (TIA). A transesophageal echocardiogram (TEE) showed a thrombus on the watchman device (WD). Read More

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Semantic Working Memory Predicts Sentence Comprehension Performance: A Case Series Approach.

Front Psychol 2022 29;13:887586. Epub 2022 Apr 29.

T.L.L. Temple Neuroplasticity Lab, Department of Psychological Sciences, Rice University, Houston, TX, United States.

Sentence comprehension involves maintaining and continuously integrating linguistic information and, thus, makes demands on working memory (WM). Past research has demonstrated that semantic WM, but not phonological WM, is critical for integrating word meanings across some distance and resolving semantic interference in sentence comprehension. Here, we examined the relation between phonological and semantic WM and the comprehension of center-embedded relative clause sentences, often argued to make heavy demands on WM. Read More

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Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies.

Neuroimage Clin 2022 May 8;35:103038. Epub 2022 May 8.

Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea; Brain Convergence Research Center, Korea University College of Medicine, Seoul, Republic of Korea; Department of Physical Medicine and Rehabilitation, Korea University Anam Hospital, Seoul, Republic of Korea. Electronic address:

Background: Aphasia is one of the most common causes of post-stroke disabilities. As the symptoms and impact of post-stroke aphasia are heterogeneous, it is important to understand how topographical lesion heterogeneity in patients with aphasia is associated with different domains of language impairments. Here, we aim to provide a comprehensive overview of neuroanatomical basis in post-stroke aphasia through coordinate based meta-analysis of voxel-based lesion-symptom mapping studies. Read More

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Thalamic aphasia associated with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes: A case report.

Brain Dev 2022 May 10. Epub 2022 May 10.

Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan. Electronic address:

Background: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with aphasia is a rare disorder, with the associated aphasia reported as either Wernicke's or Broca's. Herein, we report a patient with MELAS complicated by thalamic aphasia.

Case: A 15-year-old right-handed girl presented with headache, nausea, right homonymous hemianopsia, and aphasia. Read More

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Electrophysiological connectivity markers of preserved language functions in post-stroke aphasia.

Neuroimage Clin 2022 7;34:103036. Epub 2022 May 7.

Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada; Department of Speech-Language Pathology, University of Toronto, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada.

Post-stroke aphasia is a consequence of localized stroke-related damage as well as global disturbances in a highly interactive and bilaterally-distributed language network. Aphasia is increasingly accepted as a network disorder and it should be treated as such when examining the reorganization and recovery mechanisms after stroke. In the current study, we sought to investigate reorganized patterns of electrophysiological connectivity, derived from resting-state magnetoencephalography (rsMEG), in post-stroke chronic (>6 months after onset) aphasia. Read More

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Biological basis and psychiatric symptoms in frontotemporal dementia.

Psychiatry Clin Neurosci 2022 May 12. Epub 2022 May 12.

Psychiatry, Osaka University Graduate School of Medicine.

Frontotemporal dementia is a neurodegenerative disease characterized by focal degeneration of the frontal and temporal lobes, clinically presenting with disinhibited behavior, personality changes, progressive non-fluent aphasia and/or impaired semantic memory. Research progress has been made in re-organizing the clinical concept of frontotemporal dementia and neuropathological classification based on multiple accumulating proteins. Alongside this progress a list of genetic mutations or variants that are causative or increase the risk of frontotemporal dementia have been identified and some of these gene products are extensively studied. Read More

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Adaptation of The Scenario Test for Greek-speaking people with aphasia: A reliability and validity study.

Int J Lang Commun Disord 2022 May 12. Epub 2022 May 12.

The Brain and Neurorehabilitation Lab, Department of Rehabilitation Sciences, Cyprus University of Technology, Limassol, Cyprus.

Background: Evidence-based assessments for people with aphasia (PWA) in Greek are predominantly impairment based. Functional communication (FC) is usually underreported and neglected by clinicians. This study explores the adaptation and psychometric testing of the Greek (GR) version of The Scenario Test. Read More

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Development of the relaxation intervention: co-design with stroke survivors with aphasia.

Disabil Rehabil 2022 May 13:1-13. Epub 2022 May 13.

Graduate School of Health, University of Technology Sydney, Sydney, Australia.

Purpose: Anxiety is common after stroke and more prevalent in survivors with aphasia. Relaxation is an effective first-line therapy. The current study aimed to obtain the perspectives of stroke survivors with aphasia to inform the development of an accessible, technology-based, relaxation intervention. Read More

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Simulated attack reveals how lesions affect network properties in post-stroke aphasia.

J Neurosci 2022 May 11. Epub 2022 May 11.

Department of Neurology, Georgetown University, Washington, DC, 20007, USA.

Aphasia is a prevalent cognitive syndrome caused by stroke. The rarity of premorbid imaging and heterogeneity of lesion obscures the links between the local effects of the lesion, global anatomical network organization, and aphasia symptoms. We applied a simulated attack approach in humans to examine the effects of 39 stroke lesions (16 females) on anatomical network topology by simulating their effects in a control sample of 36 healthy (15 females) brain networks. Read More

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Incidence of post-stroke depression symptoms and potential risk factors in adults with aphasia in a comprehensive stroke center.

Top Stroke Rehabil 2022 May 11:1-11. Epub 2022 May 11.

Departments of Neurology and Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Introduction: Depression may be a frequent sequela after stroke, however, its incidence has rarely been reported. The likelihood of post-stroke depression (PSD) may relate to individual factors including the presence of aphasia, which also complicates PSD diagnosis. The current study's purpose was to investigate the incidence of PSD symptoms in adults with aphasia, compare it to the incidence of PSD symptoms in adults without aphasia, and to identify potential risk factors for developing PSD in adults with aphasia. Read More

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