17,030 results match your criteria Aphasia


Difficulty differentiating a case of posterior cortical atrophy from a psychogenic disturbance of vision.

Authors:
Eiji Kirino

Psychogeriatrics 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.

Differentiating posterior cortical atrophy (PCA) from other diseases can be difficult and time-consuming, and there is a particularly high possibility of misdiagnosis when psychiatrists diagnose complaints related to visual perception. Here, a case of PCA involving prominent visual perceptual disorders is reported; PCA was difficult to distinguish from psychogenic disturbance of vision in this case. For a year, a 59-year-old woman had had visual perceptual disorders, including a distorted view and prosopagnosia. Read More

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http://dx.doi.org/10.1111/psyg.12455DOI Listing

Epithelioid glioblastoma presenting as aphasia in a young adult with ovarian cancer: A case report.

Clin Case Rep 2019 Apr 18;7(4):821-825. Epub 2019 Mar 18.

Department of Neurosurgery Cooper University Hospital Camden New Jersey.

Our patient's clinical history and preoperative radiographic evaluation suggested central nervous system (CNS) metastatic disease. Ultimately, final pathology revealed epithelioid glioblastoma (eGBM), a newly classified CNS primary tumor. This reinforces the importance of direct tissue sampling and including eGBM on the differential for young patients with histories of systemic cancer presenting with new CNS lesions. Read More

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http://dx.doi.org/10.1002/ccr3.2088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452522PMC

Selection of neuropsychological tasks from a language test battery that optimally related to the function of each cortical area: Toward making a cognitive cortical map.

Authors:
Yasuhiro Suzuki

Neuroimage Clin 2019 Mar 28;22:101799. Epub 2019 Mar 28.

Department of Neurology, Shizuoka Saiseikai general hospital, 1-1-1 Oshika, Suruga-ku, Shizuoka 422-8527, Japan. Electronic address:

We developed a cortical language map from performance data on a language test battery in patients with brain lesions. The research problem was how to select the subtest that was most related to the function of each cortical area from the battery. When studied by voxel-based lesion-symptom mapping (VLSM), patients were divided into two groups: those with and without a lesion at each particular region. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101799DOI Listing

F-Flortaucipir in TDP-43 associated frontotemporal dementia.

Sci Rep 2019 Apr 15;9(1):6082. Epub 2019 Apr 15.

Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.

Retention of F-Flortaucipir is reportedly increased in the semantic variant of primary progressive aphasia (svPPA), which is dominated by TDP-43 pathology. However, it is unclear if F-Flortaucipir is also increased in other TDP-43 diseases, such as bvFTD caused by a C9orf72 gene mutation. We therefore recruited six C9orf72 expansion carriers, six svPPA patients, and 54 healthy controls. Read More

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http://dx.doi.org/10.1038/s41598-019-42625-9DOI Listing
April 2019
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Case of right hemispatial neglect and transcortical sensory aphasia following left occipitotemporoparietal glioblastoma resection.

Appl Neuropsychol Adult 2019 Apr 15:1-7. Epub 2019 Apr 15.

a Department of Psychiatry , University of Illinois College of Medicine , Chicago , Illinois , USA.

The neurobehavioral syndrome of hemispatial neglect, which can result from insults such as stroke, brain tumor, or head injury, has most frequently been described as occurring for the left-side of hemispace following lesions to the right hemisphere. While right hemispatial neglect/inattention may occur following left hemisphere lesions as well, it has received limited attention in the scientific literature. The present case describes an inpatient neuropsychological evaluation with a 67-year-old, African American man presenting with right hemispatial neglect following resection of a large glioblastoma in the left occipitotemporoparietal region. Read More

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http://dx.doi.org/10.1080/23279095.2019.1590357DOI Listing
April 2019
4 Reads

People with aphasia's perspectives of the therapeutic alliance during speech-language intervention: A Q methodological approach.

Int J Speech Lang Pathol 2019 Apr 15:1-11. Epub 2019 Apr 15.

c Faculty of Health and Wellbeing , Centre for Health and Social Care Research, Sheffield Hallam University , Sheffield , UK.

Purpose: To identify which elements of the therapeutic alliance are important to people with aphasia (PWA) attending speech-language pathology post-stroke.

Method: A Q methodology design was adopted to explore which elements of the therapeutic alliance were valued by PWA. Statements (n = 453) relevant to the research question were extrapolated from the literature and qualitative interviews. Read More

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http://dx.doi.org/10.1080/17549507.2019.1585949DOI Listing

Executive functions in aphasia: A novel aphasia screening for cognitive flexibility in everyday communication.

Neuropsychol Rehabil 2019 Apr 15:1-19. Epub 2019 Apr 15.

a Neuroscience and Aphasia Research Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre , University of Manchester , Manchester , UK.

Besides language deficits, persons with aphasia can present with impairments in executive functions such as cognitive flexibility. Since these impairments can restrict communicative abilities, diagnostics for aphasia should include their assessment. However, tests of executive functions, including symptoms expressed in everyday communication, are lacking for aphasia. Read More

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http://dx.doi.org/10.1080/09602011.2019.1601572DOI Listing

Embodied Semantics in a Second Language: Critical Review and Clinical Implications.

Front Hum Neurosci 2019 29;13:110. Epub 2019 Mar 29.

Laboratory for Cognitive and Neurological Sciences, Neurology Unit, Medicine Section, Department of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

The role of the sensorimotor system in second language (L2) semantic processing as well as its clinical implications for bilingual patients has hitherto been neglected. We offer an overview of the issues at stake in this under-investigated field, presenting the theoretical and clinical relevance of studying L2 embodiment and reviewing the few studies on this topic. We highlight that (a) the sensorimotor network is involved in L2 processing, and that (b) in most studies, L2 is differently embodied than L1, reflected in a lower degree or in a different pattern of L2 embodiment. Read More

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https://www.frontiersin.org/article/10.3389/fnhum.2019.00110
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http://dx.doi.org/10.3389/fnhum.2019.00110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449436PMC
March 2019
1 Read

The impact of aphasia on Internet and technology use.

Disabil Rehabil 2019 Apr 13:1-11. Epub 2019 Apr 13.

b Speech and Language Sciences , Newcastle University , Newcastle , UK.

Purpose: This study compared Internet use post-stroke in people with aphasia (n = 25) and without aphasia (n = 17). The purpose was to understand how people with aphasia were using the Internet and to investigate the impact of aphasia on their use.

Materials And Methods: A face-to-face supported questionnaire explored the use of technologies, types of Internet use, traditional and Internet communication, the perception of abilities, and possible barriers to acquiring or improving Internet skills. Read More

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http://dx.doi.org/10.1080/09638288.2019.1580320DOI Listing

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest.

J Neurol Neurosurg Psychiatry 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK

Background: Frontotemporal dementia (FTD) is a pathologically heterogeneous neurodegenerative disorder associated usually with tau or TDP-43 pathology, although some phenotypes such as logopenic variant primary progressive aphasia are more commonly associated with Alzheimer's disease pathology. Currently, there are no biomarkers able to diagnose the underlying pathology during life. In this study, we aimed to investigate the potential of novel tau species within cerebrospinal fluid (CSF) as biomarkers for tau pathology in FTD. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319266DOI Listing

Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease.

Neuroimage Clin 2019 Apr 3;23:101811. Epub 2019 Apr 3.

Department of Bio-convergence Engineering, Korea University, Seoul, Republic of Korea; School of Biomedical Engineering, Korea University, Seoul, Republic of Korea. Electronic address:

Background: In a clinical setting, an individual subject classification model rather than a group analysis would be more informative. Specifically, the subtlety of cortical atrophy in some frontotemporal dementia (FTD) patients and overlapping patterns of atrophy among three FTD clinical syndromes including behavioral variant FTD (bvFTD), non-fluent/agrammatic variant primary progressive aphasia (nfvPPA), and semantic variant PPA (svPPA) give rise to the need for classification models at the individual level. In this study, we aimed to classify each individual subject into one of the diagnostic categories in a hierarchical manner by employing a machine learning-based classification method. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101811DOI Listing
April 2019
1 Read

A rare case of the postoperative symptomatic cyst formation after the resection of a large convexity meningioma.

World Neurosurg 2019 Apr 8. Epub 2019 Apr 8.

Background: Symptomatic cyst formation after brain tumor resection is a rare complication of the early postoperative phase. We describe a complicated case of the postoperative symptomatic cyst formation after gross total removal of a convexity meningioma.

Case Description: A 59-years-old woman presented with recent onset motor aphasia, and magnetic resonance image revealed a left convexity tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193101
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http://dx.doi.org/10.1016/j.wneu.2019.04.022DOI Listing
April 2019
3 Reads

Analysis of population recognition of pictures from the sentence production program for aphasia.

Codas 2019 8;31(2):e20180193. Epub 2019 Apr 8.

Departamento de Fonoaudiologia, Universidade Federal de São Paulo - UNIFESP - São Paulo (SP), Brasil.

Purpose: To analyze the recognition of the pictures and contexts familiarity from the Sentence Production Program for Aphasia (SPPA) to acquire data determining its potential use in Portuguese and/or need for adaption.

Methods: The stimuli for English speakers were first translated, back-translated and adjusted without changing the syntactic structures of the phrases. The material was then tested in 39 highly literate individuals. Read More

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http://dx.doi.org/10.1590/2317-1782/20182018193DOI Listing
April 2019
1 Read

Clinical presentation of brain metastases from endometrial carcinoma: A case series.

Gynecol Oncol Rep 2019 May 20;28:79-83. Epub 2019 Mar 20.

University of Colorado Denver, Department of Obstetrics and Gynecology, Aurora, CO, United States.

Brain metastases from endometrial carcinoma are rare, however they do occur, and they are associated with an especially poor prognosis. There is evidence demonstrating improved outcomes with early diagnosis and subsequent multimodal treatment. This study therefore aims to review cases of brain metastases from endometrial carcinoma with specific focus on clinical presentation and disease history. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434091PMC
May 2019
1 Read

Progression of Aphasia Severity in the Chronic Stages of Stroke.

Am J Speech Lang Pathol 2019 Apr 8:1-11. Epub 2019 Apr 8.

Department of Communication Sciences and Disorders, University of South Carolina, Columbia.

Background and Purpose The severity of aphasic impairment in chronic stroke survivors is typically thought to be stable by 6 months postonset. However, a recent study showed that stroke survivors with aphasia experience language improvement or decline in the chronic phase, years beyond onset. Little is known about why some individuals improve whereas others remain stable or decline. Read More

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http://dx.doi.org/10.1044/2018_AJSLP-18-0123DOI Listing
April 2019
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[Rehabilitation possibilities and results after neurosurgical intervention of brain tumors].

Ideggyogy Sz 2019 Mar;72(3-4):123-129

Országos Orvosi Rehabilitációs Intézet, Agysérültek Rehabilitációs Osztálya, Budapest.

Background And Purpose: Authors examined the rehabilitation possi-bi-lities, necessities, and results of patients after operation with brain tumor, and report their experiences.

Methods: Retrospective, descriptive study at the Brain Injury Rehabilitation Unit, in National Institute for Medical Rehabilitation. Patients were admitted consecutively after rehabilitation consultation, from different hospitals, following surgical intervention of brain tumors, between 01 January 2001 and 31 December 2016. Read More

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http://dx.doi.org/10.18071/isz.72.0123DOI Listing
March 2019
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[" acupuncture" combined with speech training for post-stroke aphasia].

Zhongguo Zhen Jiu 2019 Apr;39(4):355-8

Clinical College of Acupuncture and Orthopaedics, Anhui University of TCM.

Objective: To verify the clinical efficacy of " acupuncture" combined with speech training for post-stroke aphasia.

Methods: A total of 68 patients with post-stroke aphasia were randomly divided into an observation group and a control group, 34 cases in each one. The patients in the control group were treated with basic therapy and speech rehabilitation exercises (mainly Schuell's aphasia stimulation therapy). Read More

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http://dx.doi.org/10.13703/j.0255-2930.2019.04.003DOI Listing
April 2019
3 Reads

Effects of Phonomotor Treatment on discourse production.

Aphasiology 2019 4;33(2):125-139. Epub 2018 Sep 4.

VA Puget Sound Health Care System, Seattle, and University of Washington, Seattle.

Background: Aphasia is an acquired language disorder that makes it difficult for people to produce and comprehend language, with every person with aphasia (PWA) demonstrating difficulty accessing and selecting words (anomia). While aphasia treatments typically focus on a single aspect of language, such as word retrieval, the ultimate goal of aphasia therapy is to improve communication, which is best seen at the level of discourse.

Aims: This retrospective study investigated the effects of one effective anomia therapy, Phonomotor Treatment, on discourse production. Read More

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http://dx.doi.org/10.1080/02687038.2018.1512080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448574PMC
September 2018
1 Read

Clinical Profile and Neuropsychiatric Outcome in Children with Anti-NMDAR Encephalitis.

Indian Pediatr 2019 Mar;56(3):247-249

Department of Pediatrics, Government Medical College, Thrissur, Kerala, India.

Six children with anti-NMDAR encephalitis were followed-up for 6 to 24 months. They presented with seizures, neuropsychiatric symptoms and movement disorder, particularly orofacial dyskinesia and choreoathetosis. Immunosuppressive therapy resulted in varying degrees of improvement; none relapsed. Read More

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March 2019
2 Reads

Profiling sentence repetition deficits in primary progressive aphasia and Alzheimer's disease: Error patterns and association with digit span.

Brain Lang 2019 Apr 3;194:1-11. Epub 2019 Apr 3.

School of Psychology, Curtin University, Perth, Western Australia, Australia.

The use of sentence repetition tasks to distinguish dementia syndromes, particularly variants of primary progressive aphasia (PPA), is receiving growing attention. Impaired sentence repetition is a core feature of logopenic variant PPA, although the underlying cognitive mechanisms of this impairment and its significance as a diagnostic criterion remain poorly understood. Sentence repetition abilities of 12 people with dementia, using an adapted error classification schema, were analyzed, along with digit span abilities, a measure frequently used to assess working memory capacity, to explore error patterns and correlations. Read More

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http://dx.doi.org/10.1016/j.bandl.2019.03.001DOI Listing
April 2019
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The Subjective Experience of Inner Speech in Aphasia Is a Meaningful Reflection of Lexical Retrieval.

J Speech Lang Hear Res 2019 Jan;62(1):106-122

Center for Brain Plasticity and Recovery, Georgetown University Medical Center, Washington, DC.

Purpose Individuals with aphasia often report that they feel able to say words in their heads, regardless of speech output ability. Here, we examine whether these subjective reports of successful "inner speech" (IS) are meaningful and test the hypothesis that they reflect lexical retrieval. Method Participants were 53 individuals with chronic aphasia. Read More

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http://dx.doi.org/10.1044/2018_JSLHR-L-18-0222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437698PMC
January 2019
1 Read

Patterns of Recovery From Aphasia in the First 2 Weeks After Stroke.

J Speech Lang Hear Res 2019 Mar;62(3):723-732

Department of Neurology, The University of Arizona, Tucson.

Purpose Recovery from aphasia after stroke has a decelerating trajectory, with the greatest gains taking place early and the slope of change decreasing over time. Despite its importance, little is known regarding evolution of language function in the early postonset period. The goal of this study was to characterize the dynamics and nature of recovery of language function in the acute and early subacute phases of stroke. Read More

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http://pubs.asha.org/doi/10.1044/2018_JSLHR-L-18-0254
Publisher Site
http://dx.doi.org/10.1044/2018_JSLHR-L-18-0254DOI Listing
March 2019
5 Reads

Lexical processing depends on sublexical processing: Evidence from the visual world paradigm and aphasia.

Atten Percept Psychophys 2019 Apr 3. Epub 2019 Apr 3.

Department of Psychological Sciences, Rice University, Houston, TX, USA.

Some early studies of people with aphasia reported strikingly better performance on lexical than on sublexical speech perception tasks. These findings challenged the claim that lexical processing depends on sublexical processing and suggested that acoustic information could be mapped directly to lexical representations. However, Dial and Martin (Neuropsychologia 96: 192-212, 2017) argued that these studies failed to match the discriminability of targets and distractors for the sublexical and lexical stimuli and showed that when using closely matched tasks with natural speech tokens, no patient performed substantially better at the lexical than at the sublexical processing task. Read More

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http://dx.doi.org/10.3758/s13414-019-01718-3DOI Listing
April 2019
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Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia.

Neurology 2019 Apr 3. Epub 2019 Apr 3.

From the Program in Speech and Hearing Bioscience and Technology (C.C., J.R.G.), Division of Medical Sciences, Harvard University, Cambridge; Frontotemporal Disorders Unit (C.C., M.Q., A.T., M.B., B.C.D.), Massachusetts General Hospital; Department of Communication Sciences and Disorders (C.C., J.R.G.), MGH Institute of Health Professions; and Department of Neurology (B.C.D.), Harvard Medical School, Boston, MA.

Objective: To evaluate whether a quantitative speech measure is effective in identifying and monitoring motor speech impairment (MSI) in patients with primary progressive aphasia (PPA) and to investigate the neuroanatomical basis of MSI in PPA.

Methods: Sixty-four patients with PPA were evaluated at baseline, with a subset (n = 39) evaluated longitudinally. Articulation rate (AR), a quantitative measure derived from spontaneous speech, was measured at each time point. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007367DOI Listing

Longitudinal F-FDG PET and MRI Reveal Evolving Imaging Pathology That Corresponds to Disease Progression in a Patient With ALS-FTD.

Front Neurol 2019 19;10:234. Epub 2019 Mar 19.

Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.

Single time point positron emission tomography (PET) studies of patients with amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD), have demonstrated hypometabolism or hypermetabolism in certain brain regions. To determine whether longitudinal (at baseline and 20.4 months later) PET and magnetic resonance imaging (MRI) reveal evolving brain imaging pathology corresponding to clinical progression in a patient with ALS-FTD, cerebral glucose metabolic rate, cortical thickness (CT) and cortical area (CA) were obtained and symmetric percent change (SPC) for each calculated. Read More

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http://dx.doi.org/10.3389/fneur.2019.00234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433744PMC
March 2019
3 Reads

[A Trial of Unified Management of Language Tasks Using a Tablet Device for Language Area Mapping].

No Shinkei Geka 2019 Mar;47(3):357-365

Graduate School of Education, Tohoku University.

Language tasks must be based on perioperative neuropsychological evaluation during intraoperative language area mapping for the resection of brain tumor near the language cortex under awake craniotomy. However, flexibility is needed during surgery, because actions during surgery must change based on neurological symptoms and the presence or absence of aphasia. Here, we developed software to assess patients' ability to complete language tasks during surgery by using a tablet device; these language tasks serve as indicators of changes in patient status. Read More

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http://dx.doi.org/10.11477/mf.1436203944DOI Listing
March 2019
6 Reads

Speech and Language Dysfunctions in Patients with Cerebrocortical Disorders Admitted in a Neurosurgical Unit.

Asian J Neurosurg 2019 Jan-Mar;14(1):87-89

Department of Neurosurgery, Narayana Medical College Hospital, Nellore, Andhra Pradesh, India.

Introduction: Speech and language abnormality among brain injury patients are common, especially during the acute stage. The details of same from Andhra Pradesh (AP) state are limited. The present study provides details of speech and language abnormality among brain damage patients, from a tertiary care hospital AP. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_240_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417298PMC
April 2019
1 Read

An overview of outcome measures used in neuropsychological rehabilitation research on adults with acquired brain injury.

Neuropsychol Rehabil 2019 Apr 2:1-26. Epub 2019 Apr 2.

a Department of Neuropsychology & Psychopharmacology, Faculty of Psychology & Neuroscience , Maastricht University , Maastricht , Netherlands.

Outcome measurement is the cornerstone of evidence-based health care including neuropsychological rehabilitation. A complicating factor for outcome measurement in neuropsychological rehabilitation is the enormous number of measures available and the lack of a standard set of outcome measures. As a first step towards such a set, we reviewed intervention evaluation studies of the last 20 years to get an overview of instruments used for measuring outcome. Read More

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http://dx.doi.org/10.1080/09602011.2019.1589533DOI Listing
April 2019
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Health Related Quality of Life in Adult Low and High-Grade Glioma Patients Using the National Institutes of Health Patient Reported Outcomes Measurement Information System (PROMIS) and Neuro-QOL Assessments.

Front Neurol 2019 15;10:212. Epub 2019 Mar 15.

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States.

Health related quality of life (HRQOL) measures have become increasingly important in the management of glioma patients in both research and clinical practice settings. Functional impairment is common in low-grade and high-grade glioma patients as the disease has both oncological and neurological manifestations. Natural disease history as well as medical or surgical treatment can negatively influence HRQOL. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00212
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http://dx.doi.org/10.3389/fneur.2019.00212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428723PMC
March 2019
4 Reads

Alzheimer's Disease Including Focal Presentations.

Semin Neurol 2019 Apr 29;39(2):213-226. Epub 2019 Mar 29.

Department of Neurology, Institute of Memory and Alzheimer's Disease, Assistance Publique - Hopitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Read More

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http://dx.doi.org/10.1055/s-0039-1681041DOI Listing
April 2019
2 Reads

Crossed aphasia confirmed by fMRI in a case with nonfluent variant of primary progressive aphasia carrying a GRN mutation.

J Neurol 2019 May 29;266(5):1274-1279. Epub 2019 Mar 29.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, Italy.

Objectives: To characterize patterns of language lateralization in a right-handed woman with nonfluent/agrammatic primary progressive aphasia (nfvPPA) clinical picture despite showing a prevalent right-sided brain damage.

Methods: We report a case of a 58-year-old woman with nfvPPA diagnosis (age at onset = 55) previously described as a crossed aphasia case with progranulin mutation. At 2 years from the first visit, patient underwent 3DT1-weighted and a task-based functional MRI (fMRI). Read More

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http://dx.doi.org/10.1007/s00415-019-09298-wDOI Listing
May 2019
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Adolphe Gubler (1821-1879) or Parisian neurology outside La Salpêtrière in the age of Jean-Martin Charcot.

Authors:
O Walusinski

Rev Neurol (Paris) 2019 Apr 26;175(4):207-216. Epub 2019 Mar 26.

20, rue de Chartres, 28160 Brou, France. Electronic address:

Adolphe Gubler (1821-1879) is a typical example of a 19th century hospital physician in Paris. Head of a medical unit at Beaujon hospital in 1855, he was nominated to the treatment and pharmacognosia Chair in 1868. He trained many students who became his disciples and remained very close to him. Read More

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http://dx.doi.org/10.1016/j.neurol.2018.07.010DOI Listing
April 2019
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Self-reported inner speech relates to phonological retrieval ability in people with aphasia.

Conscious Cogn 2019 Mar 25;71:18-29. Epub 2019 Mar 25.

Center for Brain Plasticity and Recovery, Georgetown University Medical Center, United States; Department of Neurology, Georgetown University Medical Center, United States; Center for Aphasia Research and Rehabilitation, Georgetown University Medical Center, United States; Research Division, MedStar National Rehabilitation Hospital, United States.

Many individuals with aphasia report the ability to say words in their heads despite spoken naming difficulty. Here, we examined individual differences in the experience of inner speech (IS) in participants with aphasia to test the hypotheses that self-reported IS reflects intact phonological retrieval and that articulatory output processing is not essential to IS. Participants (N = 53) reported their ability to name items correctly internally during a silent picture-naming task. Read More

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http://dx.doi.org/10.1016/j.concog.2019.03.005DOI Listing
March 2019
1 Read

Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.

Neuroimage Clin 2019 Mar 16;22:101751. Epub 2019 Mar 16.

University of California, Memory and Aging Center, Department of Neurology, San Francisco, United States; University of California, Department of Pathology, San Francisco, United States.

Mutations in progranulin (GRN) cause heterogeneous clinical syndromes, including behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), corticobasal syndrome (CBS) and Alzheimer-type dementia (AD-type dementia). Human studies have shown that presymptomatic GRN carriers feature reduced connectivity in the salience network, a system targeted in bvFTD. Mice with homozygous deletion of GRN, in contrast, show thalamo-cortical hypersynchrony due to aberrant pruning of inhibitory synapses onto thalamo-cortical projection neurons. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438992PMC
March 2019
4 Reads

Significance of speech production errors on cross-linguistic processing in Sepedi-English individuals with bilingual aphasia: a case series analysis.

Top Stroke Rehabil 2019 Mar 27:1-13. Epub 2019 Mar 27.

b Department of Science, Mathematics and Technology Education , University of Pretoria , Pretoria , South Africa.

Background: Bilingual aphasia forms a significant part of speech-language pathologists' (SLP) caseload, globally, and specifically in South Africa. Few tools supporting clinical decision-making are available due to limited understanding of typical and disordered cross-linguistic processing (how the languages interact). Speech errors may provide insight about "hidden" bilingual mechanisms. Read More

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http://dx.doi.org/10.1080/10749357.2019.1593612DOI Listing
March 2019
3 Reads

Augmented Dyadic Therapy Boosts Recovery of Language Function in Patients With Nonfluent Aphasia.

Stroke 2019 Mar 27:STROKEAHA118023729. Epub 2019 Mar 27.

Institute for Bioengineering of Catalonia, Barcelona Institute of Science and Technology, and Synthetic, Perceptive, Emotive and Cognitive Systems Lab Barcelona, Spain (K.G., B.R.B., P.V.).

Background and Purpose- Evidence suggests that therapy can be effective in recovering from aphasia, provided that it consists of socially embedded, intensive training of behaviorally relevant tasks. However, the resources of healthcare systems are often too limited to provide such treatment at sufficient dosage. Hence, there is a need for evidence-based, cost-effective rehabilitation methods. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023729DOI Listing
March 2019
1 Read

The Role of Word Properties in Performance on Fluency Tasks in People with Primary Progressive Aphasia.

J Alzheimers Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA.

People with primary progressive aphasia (PPA) present language difficulties that require lengthy assessments and follow-ups. Despite individual differences, people with PPA are often classified into three variants that present some distinctive language difficulties. We analyzed the data of 6 fluency tasks (i. Read More

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http://dx.doi.org/10.3233/JAD-180990DOI Listing
March 2019
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105 Inappropriate ICD Shocks in a Patient with Dilated Cardiomyopathy and Broca's Aphasia.

Case Rep Cardiol 2019 14;2019:8302591. Epub 2019 Feb 14.

Heart Center Brandenburg-Department of Cardiology and Medical School Brandenburg Theodor Fontane, Bernau bei Berlin, Germany.

With a growing number of ICD recipients, device complications are seen more frequently in the clinical setting and outpatient departments. Among the most severe are ICD infections and inappropriate therapies caused by oversensing of atrial tachycardias or lead fracture. We report on a 76-year-old female patient with dilative cardiomyopathy and Broca's aphasia after stroke, who experienced 105 consecutive inappropriate ICD shocks due to cluster missensing of her fractured ICD lead. Read More

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http://dx.doi.org/10.1155/2019/8302591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393888PMC
February 2019
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F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia.

Dement Neurocogn Disord 2018 Sep 10;17(3):110-119. Epub 2018 Dec 10.

Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea.

Background And Purpose: To analyze F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA).

Methods: Thirty-one participants, including those with Alzheimer's disease (AD, =13), navPPA (=3), and those with normal control (NC, =15) who completed 3 Tesla magnetic resonance imaging, F-THK5351 PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of F-THK5351 in navPPA patients. Read More

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http://dx.doi.org/10.12779/dnd.2018.17.3.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428011PMC
September 2018
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Early Onset Alzheimer's Disease Presenting as Logopenic Primary Progressive Aphasia.

Dement Neurocogn Disord 2018 Jun 31;17(2):66-70. Epub 2018 Jul 31.

Department of Neurology, Wonkwang University School of Medicine and Regional Cardiocerebrovascular Center, Iksan, Korea.

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http://dx.doi.org/10.12779/dnd.2018.17.2.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427970PMC
June 2018
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Insurance and Flow-Alteration Superficial Temporal Artery to Middle Cerebral Artery (STA-MCA) Bypass in Management of Complex Anterior Intracranial Circulation Aneurysms in Postendovascular Era.

World Neurosurg 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Optimal management of complex anterior circulation aneurysms is an enigmatic challenge because of frequent involvement of major vessel bifurcation, choroidal vessels, and lenticulostriate/thalamostriate perforators. Cerebral ischemia associated with prolonged clipping time is a major concern pertinent to their surgical management, especially in patients with poor cross-flow. To circumvent this hurdle, single/double-barrel low-flow superficial temporal artery (STA) to middle cerebral artery (M3/M4-MCA) can be performed, which can maintain distal cerebral perfusion while facilitating safe clip reconstruction of complex MCA and supraclinoidal internal carotid artery (ICA) aneurysms involving ICA bifurcation or supraclinoidal ICA aneurysms with poor cross-circulation-insurance bypass, as well as supplement/alter blood flow after MCA aneurysm trapping-flow-alteration bypass. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.109DOI Listing
March 2019
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Factors Influencing Quality of Life in Stroke Patients: Focus on Eating Habits.

J Stroke Cerebrovasc Dis 2019 Mar 19. Epub 2019 Mar 19.

Department of Nursing Science, Hirosaki University Graduate School of Health Science, Hirosaki, Japan. Electronic address:

Background: Adherence to healthy lifestyle factors has been shown to improve outcomes after stroke. This study aimed to identify lifestyle factors about eating habits that may affect the quality of life (QOL) in elderly stroke patients.

Methods: Fifty elderly patients with a first-ever stroke were enrolled. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.031DOI Listing
March 2019
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Perspectives of people with aphasia post-stroke towards personal recovery and living successfully: A systematic review and thematic synthesis.

PLoS One 2019 22;14(3):e0214200. Epub 2019 Mar 22.

School of Allied Health, Faculty of Education and Health Sciences, University of Limerick, Limerick, Republic of Ireland.

Background: There is increased focus on supporting people with chronic conditions to live well via person-centred, integrated care. There is a growing body of qualitative literature examining the insider perspectives of people with post-stroke aphasia (PWA) on topics relating to personal recovery and living successfully (PR-LS). To date no synthesis has been conducted examining both internal and external, structural influences on living well. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214200PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430359PMC
March 2019
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Poststroke Aphasia Rehabilitation: Why All Talk and No Action?

Neurorehabil Neural Repair 2019 Apr 22;33(4):235-244. Epub 2019 Mar 22.

3 Moss Rehabilitation Research Institute, Elkins Park, PA, USA.

There is ample agreement in the scientific literature, across diverse areas of study, that suggests that language and movement are interrelated. In particular, it is widely held that the upper limb and hand play a key role in language use. Aphasia, a common, disabling language disorder frequently associated with stroke, requires new restorative methods. Read More

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http://journals.sagepub.com/doi/10.1177/1545968319834901
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http://dx.doi.org/10.1177/1545968319834901DOI Listing
April 2019
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The clinical management and rehabilitation of post stroke aphasia in Italy: evidences from the literature and clinical experience.

Authors:
Flavia Mattioli

Neurol Sci 2019 Mar 21. Epub 2019 Mar 21.

Neuropsychology Unit, ASST Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy.

Aphasia is one of the most devastating symptoms in stroke survivors and severely affects patients' communication, quality of life, and social interactions. Several factors are critical to the prediction of aphasia recovery, including acute stroke management and subsequent language rehabilitation. A comprehensive assessment of language skills with appropriate instruments in different phases of post stroke months and years is needed in patients, in order to monitor their language improvement and to guide speech therapies over time. Read More

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http://dx.doi.org/10.1007/s10072-019-03844-0DOI Listing
March 2019
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1.495 Impact Factor

Analysing coherence of oral discourse among Cantonese speakers in Mainland China with traumatic brain injury and cerebrovascular accident.

Int J Speech Lang Pathol 2019 Mar 21:1-11. Epub 2019 Mar 21.

b Department of Chinese and Bilingual Studies , The Hong Kong Polytechnic University , Hong Kong , Hong Kong.

Purpose: Coherence can reflect subtle language deficits in individuals with traumatic brain injury (TBI) and cerebrovascular accident (CVA). This study aimed at investigating whether global and local coherence in Cantonese-speaking adults with CVA and TBI differ from non-brain-injured (NBI) speakers. Factors contributing to the coherence ratings and impacts of elicitation tasks on coherence were examined. Read More

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http://dx.doi.org/10.1080/17549507.2019.1581256DOI Listing
March 2019
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Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma: A case report.

Medicine (Baltimore) 2019 Mar;98(12):e14821

Department of Respiratory Internal Medicine, Hiroshima University Hospital, Minami-ku, Hiroshima, Japan.

Rationale: The efficacy of direct oral anticoagulants (DOACs) in the treatment and prophylaxis of cancer-related venous thromboembolism (VTE) is reportedly similar to that of heparin. However, the effect of DOACs on the prophylaxis of cancer-related arterial thromboembolism (ATE) remains unclear. To our knowledge, we present the 1st case where cerebral ATE was encountered during edoxaban administration for VTE in a patient with lung adenocarcinoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000014821DOI Listing
March 2019
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Preferential Disruption of Auditory Word Representations in Primary Progressive Aphasia With the Neuropathology of FTLD-TDP Type A.

Cogn Behav Neurol 2019 03;32(1):46-53

Mesulam Center for Cognitive Neurology and Alzheimer's Disease.

Four patients with primary progressive aphasia displayed a greater deficit in understanding words they heard than words they read, and a further deficiency in naming objects orally rather than in writing. All four had frontotemporal lobar degeneration-transactive response DNA binding protein Type A neuropathology, three determined postmortem and one surmised on the basis of granulin gene (GRN) mutation. These features of language impairment are not characteristic of any currently recognized primary progressive aphasia variant. Read More

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http://dx.doi.org/10.1097/WNN.0000000000000180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430124PMC
March 2019
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Neurotoxicity associated with cancer immunotherapy: immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy.

Curr Opin Neurol 2019 Mar 19. Epub 2019 Mar 19.

Department of Oncology.

Purpose Of Review: Immune checkpoint inhibitors (ICPI) and chimeric antigen receptor T cells (CAR-T) represent novel therapies recently approved to treat a number of human cancers. As both approaches modulate the immune system, they can generate a number of immune-related adverse events (irAEs), including a large spectrum of novel neurological toxicities. These are of special interest given their potential severity and risk of compromising further oncologic treatment. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000686DOI Listing
March 2019
2 Reads