16,914 results match your criteria Aphasia


Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (svPPA).

eNeuro 2018 Nov-Dec;5(6). Epub 2018 Jan 10.

Department of Neurology and Penn Frontotemporal Degeneration Center.

This study examines longitudinal changes in the concreteness of nouns produced by human patients with semantic variant primary progressive aphasia (svPPA). Cross-sectional studies show that patients with svPPA demonstrate severe loss of concrete noun knowledge linked to atrophy of the left ventral temporal lobe. It is unknown how disease spread and duration affect the magnitude of the concreteness impairment in svPPA. Read More

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http://dx.doi.org/10.1523/ENEURO.0197-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377408PMC
January 2018

Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Associated With Adenoviral Pneumonia.

Child Neurol Open 2019 5;6:2329048X19826288. Epub 2019 Feb 5.

Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Acute encephalopathy with biphasic seizures and late reduced diffusion is a subtype of acute encephalopathy described in a cohort of Japanese children. Few cases have been reported in countries other than Japan. It is characterized clinically by biphasic seizures and late reduced subcortical diffusion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1177/2329048X19826288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365989PMC
February 2019

Atrial standstill presenting as cerebral infarction in a 7-year-old girl.

SAGE Open Med Case Rep 2019 4;7:2050313X19827735. Epub 2019 Feb 4.

Department of Pediatrics, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Atrial standstill is a rare arrhythmia defined by the absence of mechanical and electrical activity in the atria. Few cases of atrial standstill have been described in children, none of which have presented with cerebral infarction confirmed by imaging. We report a unique case of a 7-year-old girl presenting with expressive aphasia, central facial palsy and irregular pulse with cerebral infarction secondary to atrial standstill. Read More

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http://dx.doi.org/10.1177/2050313X19827735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366293PMC
February 2019

Emergence of artistic talent in progressive nonfluent aphasia: a case report.

Psychogeriatrics 2019 Feb 19. Epub 2019 Feb 19.

Department of Neuropsychiatry, Faculty of Life sciences, Kumamoto University, Kumamoto, Japan.

Some patients with frontotemporal lobar degeneration have developed artistic skills after the onset mainly in painting and music. Most of these cases have semantic dementia (SD), one of the frontotemporal lobar degeneration subtypes. In previously reported cases, the paintings made by patients with SD were usually hyper realistic, without a significant symbolic or abstract component. Read More

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http://dx.doi.org/10.1111/psyg.12437DOI Listing
February 2019

Humour in clinical-educational interactions between graduate student clinicians and people with aphasia.

Int J Lang Commun Disord 2019 Feb 19. Epub 2019 Feb 19.

Department of Speech and Hearing Sciences, Lamar University, Beaumont, TX, USA.

Background: During clinical interactions, clinicians and people with aphasia (PWA) use humour and laughter for a range of purposes, most of which contribute to friendly interactions in which the participants appear to develop a positive regard for one another. Moreover, humour is a vital component of facework, or the processes interactants engage in to protect their own and one another's well-respected, public personas.

Aims: To examine the ways in which speech-language pathology graduate student clinicians enlist humour during one-on-one therapy sessions for PWA. Read More

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http://dx.doi.org/10.1111/1460-6984.12461DOI Listing
February 2019

When Words Fail: Providing Effective Psychological Treatment for Depression in Persons with Aphasia.

J Clin Psychol Med Settings 2019 Feb 18. Epub 2019 Feb 18.

Advanced Studies in Psychology, Kean University, 1000 Morris Ave., Union, NJ, 07083, USA.

More than 2 million people in the United States are living with some form of aphasia, a communication disorder that has been associated with high incidence of clinical depression. Despite their large numbers, persons with aphasia have received little clinical attention from psychologists and other mental health providers. The life participation interventions and supported communication methods developed and routinely employed by speech-language pathologists could assist mental health professionals in addressing the needs of this underserved population. Read More

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http://dx.doi.org/10.1007/s10880-019-09608-4DOI Listing
February 2019

Combining rTMS With Intensive Language-Action Therapy in Chronic Aphasia: A Randomized Controlled Trial.

Front Neurosci 2018 4;12:1036. Epub 2019 Feb 4.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al. Read More

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http://dx.doi.org/10.3389/fnins.2018.01036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369187PMC
February 2019

TARDBP mutation associated with semantic variant primary progressive aphasia, case report and review of the literature.

Neurocase 2019 Feb 16:1-5. Epub 2019 Feb 16.

a Department of Neurology , Hospital Universitario 12 de Octubre , Madrid , Spain.

Semantic variant primary progressive aphasia (svPPA) is a clinical syndrome included in the frontotemporal dementia (FTD) spectrum. Unlike other forms of FTD, it is sporadic in the majority of cases and not commonly associated with motor neuron disease (MND). We describe a case of svPPA associated with MND in the same family, due to a mutation of the transactive response DNA binding protein (TARDBP) gene, and review the literature. Read More

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http://dx.doi.org/10.1080/13554794.2019.1581225DOI Listing
February 2019

"Looks familiar, but I do not know who she is": The role of the anterior right temporal lobe in famous face recognition.

Cortex 2019 Jan 23;115:72-85. Epub 2019 Jan 23.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA; Department of Neurology, Dyslexia Center, University of California, San Francisco, CA, USA.

Processing a famous face involves a cascade of steps including detecting the presence of a face, recognizing it as familiar, accessing semantic/biographical information about the person, and finally, if required, production of the proper name. Decades of neuropsychological and neuroimaging studies have identified a network of occipital and temporal brain regions ostensibly comprising the 'core' system for face processing. Recent research has also begun to elucidate upon an 'extended' network, including anterior temporal and frontal regions. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.006DOI Listing
January 2019
2 Reads

The first case report of bilateral spontaneous otogenic pneumocephalus.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Dep. of Neurosurgery and Neurooncology, Charles University in Prague, 1st Medical Faculty, Central Military Hospital Stresovice, Czech Republic. Electronic address:

Background: Pneumocephalus is commonly associated with cranial trauma including surgical interventions. Spontaneous pneumocephalus on the other hand is a rare diagnosis. Reported cases were predominantly unilateral. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.232DOI Listing
February 2019
1 Read

The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Brain and Mind Centre and Central Clinical School (R.H.T., B.G., C.D.-S., J.B.J.K., M.C.K., J.R.H., G.M.H.) and School of Medical Sciences (J.J.K.), Faculty of Medicine and Health, and Brain and Mind Centre and School of Psychology (O.P.), The University of Sydney; School of Medical Sciences (R.H.T., C.D.-S., G.M.H.), University of New South Wales & Neuroscience Research Australia; Department of Neurology (M.C.K.), Royal Prince Alfred Hospital; ARC Centre of Excellence in Cognition and its Disorders (J.R.H., O.P.); and Division of Neuroscience (B.G.), Garvan Institute of Medical Research and St Vincent's Clinical School, UNSW Sydney, New South Wales, Australia.

Objective: To assess the incidence, heritability, and neuropathology of primary progressive aphasia (PPA) with amyotrophic lateral sclerosis (ALS) in a large Australian cohort.

Methods: A total of 130 patients with a primary nonfluent variant of PPA (nfvPPA) or semantic variant of PPA (svPPA) were assessed for concomitant ALS and a strong family history of neurodegenerative diseases (Goldman score ≤3). Neuropathologic examination was carried out in 28% (n = 36) of these PPA and PPA-ALS cases that had come to autopsy. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007146DOI Listing
February 2019
2 Reads

A walk through tau therapeutic strategies.

Acta Neuropathol Commun 2019 Feb 15;7(1):22. Epub 2019 Feb 15.

AXON Neuroscience R&D Services SE, Dvorakovo nabrezie 10, 811 02, Bratislava, Slovakia.

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel from cell to cell and spread the pathology through the brain. Throughout the last decade, physiological and pathological tau have become attractive targets for AD therapies. Read More

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0664-zDOI Listing
February 2019
3 Reads

Clinical and cortical decline in the aphasic variant of Alzheimer's disease.

Alzheimers Dement 2019 Feb 11. Epub 2019 Feb 11.

NU Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, USA.

Introduction: Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation.

Methods: Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPA and PPA), an imaging biomarker of underlying Alzheimer's disease.

Results: Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPA. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.12.003DOI Listing
February 2019
1 Read

Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial.

Cerebrovasc Dis 2019 Feb 14;47(1-2):24-31. Epub 2019 Feb 14.

Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial.

Methods: Subjects in the SAMMPRIS trial were included in this study. Read More

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http://dx.doi.org/10.1159/000497245DOI Listing
February 2019

Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging.

Neural Regen Res 2019 Jun;14(6):1004-1012

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. Read More

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http://dx.doi.org/10.4103/1673-5374.250580DOI Listing
June 2019
1 Read

Counselling training for speech-language therapists working with people affected by post-stroke aphasia: a systematic review.

Int J Lang Commun Disord 2019 Feb 13. Epub 2019 Feb 13.

Discipline of Speech Pathology, School of Allied Health, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC, Australia.

Background: Speech-language therapists use counselling to address the psychological well-being of people affected by post-stroke aphasia. Speech-language therapists report low counselling knowledge, skill and confidence for working in post-stroke aphasia which may be related to a lack of counselling training specific to the needs of this client group.

Aims: To identify current training in counselling for speech-language therapists to address psychological well-being in people affected by post-stroke aphasia. Read More

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http://dx.doi.org/10.1111/1460-6984.12455DOI Listing
February 2019
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Language as a Predictor of Motor Recovery: The Case for a More Global Approach to Stroke Rehabilitation.

Neurorehabil Neural Repair 2019 Feb 13:1545968319829454. Epub 2019 Feb 13.

3 Curtin University, Perth, Western Australia, Australia.

Stroke is the third leading cause of death in the developed world and the primary cause of adult disability. The most common site of stroke is the middle cerebral artery (MCA), an artery that supplies a range of areas involved in both language and motor function. As a consequence, many stroke patients experience a combination of language and motor deficits. Read More

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http://dx.doi.org/10.1177/1545968319829454DOI Listing
February 2019
1 Read

Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia.

J Neuropathol Exp Neurol 2019 Feb 8. Epub 2019 Feb 8.

Feinberg School of Medicine, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, Illinois.

Diffusely stained phosphorylated 43-kDa TAR DNA-binding protein (TDP-43)-positive "pre-inclusions" have been described. This experiment investigated morphological subtypes of pre-inclusions and their relationship with TDP-43 inclusions in primary progressive aphasia (PPA), a dementia characterized by gradual dissolution of language. Brain sections from 5 PPA participants with postmortem diagnoses of frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) were immunohistochemically stained using an antibody to phosphorylated TDP-43 and quantitatively examined for regional and hemispheric distribution using unbiased stereology. Read More

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http://dx.doi.org/10.1093/jnen/nlz005DOI Listing
February 2019
2 Reads

Validation of Stroke Network of Wisconsin Scale at Aurora Health Care System.

J Vasc Interv Neurol 2018 Nov;10(2):69-73

Aurora Neuroscience Innovation Institute.

Background: The Stroke Network of Wisconsin (SNOW) scale, previously called the Pomona scale, was developed to predict large-vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS). The original study showed a high accuracy of this scale. We sought to externally validate the SNOW scale in an independent cohort. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350874PMC
November 2018
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Thrombolysis in Acute Ischemic Stroke after Idarucizumab for Dabigatran Etexilate Reversal in Elderly: A Case Report.

J Vasc Interv Neurol 2018 Nov;10(2):15-17

Stroke Unit, Department of Neuroscience, AOU Sassari, Italy.

Introduction: Dabigatran is one of the nonvitamin K antagonist oral anticoagulants. Thrombolytic treatment with intravenous recombinant tissue plasminogen activator is contraindicated in patients taking a DOAC. Idarucizumab was recently approved for dabigatran-activity reversing in severe bleeding, emergency surgery, or urgent procedures, but many attempts have been made to use idarucizumab in patients presenting with acute ischemic stroke in order to be eligible for thrombolysis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350876PMC
November 2018
7 Reads

Detecting frontotemporal dementia syndromes using MRI biomarkers.

Neuroimage Clin 2019 Feb 4;22:101711. Epub 2019 Feb 4.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.

Background: Diagnosing frontotemporal dementia may be challenging. New methods for analysis of regional brain atrophy patterns on magnetic resonance imaging (MRI) could add to the diagnostic assessment. Therefore, we aimed to develop automated imaging biomarkers for differentiating frontotemporal dementia subtypes from other diagnostic groups, and from one another. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369219PMC
February 2019
1 Read

Findings of Impaired Hearing in Patients With Nonfluent/Agrammatic Variant Primary Progressive Aphasia.

JAMA Neurol 2019 Feb 11. Epub 2019 Feb 11.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London, United Kingdom.

Importance: Despite being characterized as a disorder of language production, nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) is frequently associated with auditory symptoms. However, to our knowledge, peripheral auditory function has not been defined in this condition.

Objective: To assess peripheral hearing function in individuals with nfvPPA compared with healthy older individuals and patients with Alzheimer disease (AD). Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.4799DOI Listing
February 2019

Multifocal Stroke From Ozone Gas Emboli.

J Neuroophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology and Vision Sciences (PRF, EAM), University of Toronto, Toronto, Canada; and Department of Medical Imaging (LA), University of Toronto, Toronto, Canada.

A 34-year-old man with chronic neck pain was treated with regular cervical paravertebral ozone injections. After his last injection, he experienced a syncopal episode and, upon awakening, was found to have ataxia, aphasia, hemiparesis, and left sixth nerve palsy. Computed tomographic angiography demonstrated intra-arterial gas in the right vertebral artery; multiple posterior circulation infarcts were seen on brain MRI. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000754DOI Listing
February 2019
1 Read

[An assessment of the effectiveness of comprehensive neurorehabilitation in patients after ischemic stroke].

Wiad Lek 2018 ;71(9):1701-1706

Klinika Rehabilitacji i Medycyny Fizykalnej USK im. Wam, Kierunek Fizjoterapii Wydziału Wojskowo-Lekarskiego Uniwersytetu Medycznego w Łodzi, Łódź, Polska.

Objective: Introduction: Comprehensive rehabilitation after stroke is to help the patient recover optimal physical and mental condition. The multidirectional approach to the patient implemented by a multidisciplinary team: physicians, physiotherapists, neurologopedians and neuropsychologists allows the best use of the patient's potential. The aim: To evaluate the effectiveness of comprehensive neurological rehabilitation of patients after ischemic stroke. Read More

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January 2018
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Progressive Cerebral Ischemia and Intracerebral Hemorrhage after Indirect Revascularization for a Patient with Cerebral Proliferative Angiopathy.

J Stroke Cerebrovasc Dis 2019 Feb 6. Epub 2019 Feb 6.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

We previously reported a patient with cerebral proliferative angiopathy (CPA) who showed cerebral ischemia in resting and acetazolamide-stressed N-isopropyl-p-[I] iodoamphetamine single-photon emission computed tomography (I-IMP-SPECT). At onset, the patient was treated conservatively. However, during the 2 years following initial onset, his hemiparesis and aphasia had gradually aggravated and his IQ scores were markedly decreased. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.021DOI Listing
February 2019
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The "Artery of Aphasia," A Uniquely Sensitive Posterior Temporal Middle Cerebral Artery Branch that Supplies Language Areas in the Brain: Anatomy and Report of Four Cases.

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Prince of Wales Private Hospital, Sydney, Australia. Electronic address:

Background: Arterial disruption during brain surgery can cause devastating injuries to wide expanses of white and grey matter far beyond the tumor resection cavity. Such damage may occur as a result of disrupting blood flow through "en passage" arteries. Identification of these arteries is critical to prevent unforeseen neurologic sequelae during brain tumor resection. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.159DOI Listing
February 2019
3 Reads

Language Mapping of Hindi and English in A Bilingual Patient During Resection of A Right Frontal Glioma - A Case Report.

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Division of Neurosurgery, University Surgical Cluster, National University Health System (NUHS), 1E, Kent Ridge Road, Singapore 119228.

Background: Recent advancements in understanding the molecular basis of gliomas as well as new concepts of neuronal plasticity have shown importance of maximal resection in gliomas to improve progression free overall survival. Awake craniotomies with intra-operative cortical and subcortical mapping has helped to achieve this aim while allowing us to preserve executive function including language. Language mapping becomes a daunting task in individuals who are bilingual due to complexity of varied cortical representation of different languages. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.153DOI Listing
February 2019
1 Read
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Validity of an eyetracking method for capturing auditory-visual cross-format semantic priming.

J Clin Exp Neuropsychol 2019 Feb 6:1-21. Epub 2019 Feb 6.

b Springfield College , Springfield, Massachusetts , MA , USA.

Introduction: Semantic priming paradigms are important for understanding lexical-semantic processing and the nature of linguistic deficits accompanying language performance in neurologically impaired individuals such as people with aphasia. Reaction-time-(RT)-based traditional semantic priming tasks entail potential confounds, especially problematic when applied to people with aphasia, who may have concomitant neurocognitive challenges that limit task performance. Some of these confounds include requirements of following complex instructions, making metalinguistic judgments, and using speech or limb-based motor actions to indicate overt responses. Read More

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http://dx.doi.org/10.1080/13803395.2019.1567692DOI Listing
February 2019
1 Read

Exploring distinct default mode and semantic networks using a systematic ICA approach.

Cortex 2019 Jan 14;113:279-297. Epub 2019 Jan 14.

MRC Cognition & Brain Sciences Unit, University of Cambridge, Cambridge, UK. Electronic address:

Resting-state networks (RSNs; groups of regions consistently co-activated without an explicit task) are hugely influential in modern brain research. Despite this popularity, the link between specific RSNs and their functions remains elusive, limiting the impact on cognitive neuroscience (where the goal is to link cognition to neural systems). Here we present a series of logical steps to formally test the relationship between a coherent RSN with a cognitive domain. Read More

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http://dx.doi.org/10.1016/j.cortex.2018.12.019DOI Listing
January 2019
2 Reads

Urgent Middle Cerebral Artery Embolectomy of Calcified Embolus After Intravenous Thrombolysis: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurosurgery, Hospital Ceske Budejovice, Czech Republic.

This video shows an urgent microsurgical embolectomy of the inferior division of the left middle cerebral artery in a patient treated by intravenous thrombolysis (IVT). Patient was eligible for endovascular mechanical thrombectomy1; however, the interventional radiologist was not comfortable performing the procedure given prior unsuccessful attempts to remove a calcified cerebral embolus.2 A 75-yr-old female presented with an acute ischemic stroke with isolated aphasia (NIHSS 9). Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy404DOI Listing
February 2019
5 Reads

Double-Barrel Extracranial-Intracranial Bypass and Trapping of Dolichoectatic Middle Cerebral Artery Aneurysms: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona.

A dolichoectatic intracranial vessel with multiple fusiform aneurysms on the same vessel segment is rare, and usually managed with a bypass with aneurysm trapping. This video demonstrates trapping and a double-barrel superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass to treat two fusiform aneurysms in a left dolichoectatic superior MCA trunk. A 46-year-old man with AIDS presented with aphasia and hemiparesis. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy311DOI Listing
January 2019
4 Reads

The contribution of semantic memory to the recognition of basic emotions and emotional valence: Evidence from the semantic variant of primary progressive aphasia.

Soc Neurosci 2019 Feb 4:1-12. Epub 2019 Feb 4.

a Faculté de médecine, Département de réadaptation , Université Laval , Québec , QC , Canada.

There is compelling evidence that semantic memory is involved in emotion recognition. However, its contribution to the recognition of emotional valence and basic emotions remains unclear. We compared the performance of 10 participants with the semantic variant of primary progressive aphasia (svPPA), a clinical model of semantic memory impairment, to that of 33 healthy participants using three experimental tasks assessing the recognition of: 1) emotional valence conveyed by photographic scenes, 2) basic emotions conveyed by facial expressions, and 3) basic emotions conveyed by prosody sounds. Read More

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http://dx.doi.org/10.1080/17470919.2019.1577295DOI Listing
February 2019
1 Read

Improvement in functional vocabulary and generalization to conversation following a self-administered treatment using a smart tablet in primary progressive aphasia.

Neuropsychol Rehabil 2019 Feb 4:1-31. Epub 2019 Feb 4.

a Département de réadaptation , Université Laval , Québec , QC , Canada.

Currently, public services in speech-language pathology for primary progressive aphasia (PPA) are very limited, although several interventions have been shown to be effective. In this context, new technologies have the potential to enable people with PPA to improve their communication skills. The main aim of this study was to investigate the efficacy of a self-administered therapy using a smart tablet to improve naming of functional words and to assess generalization to an ecological conversation task. Read More

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http://dx.doi.org/10.1080/09602011.2019.1570943DOI Listing
February 2019
1 Read

Temporal Changes on I-Iomazenil and Cerebral Blood Flow Single-photon Emission Computed Tomography in a Patient with Anti-N-methyl-D-aspartate Receptor Encephalitis.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurology, Gunma University Graduate School of Medicine, Japan.

A 45-year-old man was admitted due to tonic seizures, aphasia, disturbance of consciousness, and abnormal behavior. Because cerebral magnetic resonance imaging findings were normal and mild cerebrospinal fluid (CSF) pleocytosis was observed, autoimmune encephalitis was suspected. The presence of anti-N-methyl-D-aspartate (NMDA) receptor antibodies in the CSF was subsequently confirmed. Read More

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http://dx.doi.org/10.2169/internalmedicine.0987-18DOI Listing
February 2019
1 Read

Progression of logopenic aphasia to frontotemporal dementia in an amyloid β-negative and F-THK-5351-positive patient.

Psychogeriatrics 2019 Feb 3. Epub 2019 Feb 3.

Department of Neuropsychiatry, Faculty of Medicine, Kindai University, Osaka, Japan.

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http://dx.doi.org/10.1111/psyg.12396DOI Listing
February 2019
1 Read

Intracranial stenting after tumor exeresis complicated by delayed kinking of the middle cerebral artery.

Acta Neurochir (Wien) 2019 Feb 2. Epub 2019 Feb 2.

Neuroradiology Unit, University Hospital of Padova, Padua, Italy.

During intracranial tumor resection, the delayed kinking of a major encased vessel has never been described in literature. We present a case which required urgent endovascular treatment performed through a stent positioning. A patient was hospitalized with symptomatic sphenoid meningioma in the left middle cranial fossa. Read More

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http://dx.doi.org/10.1007/s00701-019-03822-7DOI Listing
February 2019
1 Read

Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients.

J Neurol 2019 Feb 1. Epub 2019 Feb 1.

Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.

This study systematically investigated the neuropsychological profile of language disturbance in frontotemporal dementia-motor neuron disease (FTD-MND) using a data-driven approach. Neuroanatomical correlates of language profiles were also examined. Patients with FTD-MND (N = 26), pure motor neuron disease (N = 34), progressive non-fluent aphasia (N = 30), semantic dementia (N = 17), and controls (N = 31) underwent comprehensive language assessments. Read More

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http://dx.doi.org/10.1007/s00415-019-09216-0DOI Listing
February 2019
1 Read

F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.

Alzheimers Res Ther 2019 Jan 31;11(1):13. Epub 2019 Jan 31.

Memory and Aging Center, University of California at San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, USA.

Background: The tau positron emission tomography (PET) ligand F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer's disease (AD), but its utility in detecting tau aggregates in frontotemporal dementia (FTD) is uncertain.

Methods: We performed F-flortaucipir imaging in patients with the FTD syndromes (n = 45): nonfluent variant primary progressive aphasia (nfvPPA) (n = 11), corticobasal syndrome (CBS) (n = 10), behavioral variant frontotemporal dementia (bvFTD) (n = 10), semantic variant primary progressive aphasia (svPPA) (n = 2) and FTD associated pathogenic genetic mutations microtubule-associated protein tau (MAPT) (n = 6), chromosome 9 open reading frame 72 (C9ORF72) (n = 5), and progranulin (GRN) (n = 1). All patients underwent MRI and β-amyloid biomarker testing via C-PiB or cerebrospinal fluid. Read More

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https://alzres.biomedcentral.com/articles/10.1186/s13195-019
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http://dx.doi.org/10.1186/s13195-019-0470-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357510PMC
January 2019
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Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials.

Brain 2019 Feb;142(2):443-459

Department of Neurology, Memory and Aging Center, University of California at San Francisco (UCSF), San Francisco, CA, USA.

Frontotemporal dementia refers to a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or TDP-43 proteins. The effects of these proteins in the brain are complex, and each can present with several different clinical syndromes. Clinical efficacy trials of drugs targeting these proteins must use endpoints that are meaningful to all participants despite the variability in symptoms across patients. Read More

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https://academic.oup.com/brain/article/142/2/443/5303707
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http://dx.doi.org/10.1093/brain/awy319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351779PMC
February 2019
7 Reads

Language recovery following stroke.

Clin Neuropsychol 2019 Jan 30:1-20. Epub 2019 Jan 30.

a Department of Neurology , University of Alabama at Birmingham , Birmingham , AL, USA.

Objective: To review the research literature pertaining to post-stroke language recovery, and to discuss neurocognitive assessment in patients in the context of aphasia, time course of language recovery, factors associated with language recovery, and therapeutic techniques designed to facilitate language recovery.

Method: Articles were identified through PubMed, MEDLINE, PsychINFO, and Google Scholar searches. Examples of utilized keywords include "post-stroke aphasia," "post-stroke language recovery," "post-stroke neurocognitive assessment," and "neuropsychology and aphasia. Read More

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http://dx.doi.org/10.1080/13854046.2018.1562093DOI Listing
January 2019
1 Read

Successful Intravenous Alteplase for a Centenarian Woman with Acute Ischaemic Stroke.

Clin Exp Pharmacol Physiol 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

We report a case of a 105-year-old woman who was treated with Alteplase for acute ischaemic stroke (AIS). On arrival, this centenarian Woman had sudden-onset aphasia and right-sided hemiparesis, her baseline National Institutes of Health Stroke Scale (NIHSS) score was 21. An acute noncontrast brain CT scan showed only mild white matter disease. Read More

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http://dx.doi.org/10.1111/1440-1681.13067DOI Listing
January 2019
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[Possible Segmental Arterial Mediolysis Associated with Intraperitoneal Hemorrhage in the Acute Stage of Subarachnoid Hemorrhage:A Case Report].

No Shinkei Geka 2019 Jan;47(1):97-103

Department of Neurosurgery, Kyoto University Graduate School of Medicine.

Segmental arterial mediolysis(SAM)is a rare non-inflammatory and non-atherosclerotic arteriopathy associated with the occurrence of multiple aneurysms such as intracranial and intraperitoneal aneurysms. We report a case of intraperitoneal hemorrhage that occurred during the acute stage of subarachnoid hemorrhage(SAH). An 82-year-old woman presented with a sudden onset of loss of consciousness with a diagnosis of SAH. Read More

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http://dx.doi.org/10.11477/mf.1436203902DOI Listing
January 2019
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Acute alcohol intoxication may cause delay in stroke treatment - case reports.

BMC Neurol 2019 Jan 29;19(1):14. Epub 2019 Jan 29.

Department of Neurology, Faculty of Medicine, University of Debrecen, Moricz Zs. krt 22, Debrecen, 4032, Hungary.

Background: The signs and symptoms of acute alcohol intoxication resemble those of vertebrobasilar stroke. Due to their shared symptoms including double vision, nystagmus, dysarthria, and ataxia, the differential diagnosis of alcohol intoxication and vertebrobasilar stroke may pose a challenge. Moreover, if alcohol intoxication and stroke occur simultaneously, the signs and symptoms of stroke may be attributed to the effects of alcohol, leading to delayed stroke diagnosis and failure to perform reperfusion therapy. Read More

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http://dx.doi.org/10.1186/s12883-019-1241-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350361PMC
January 2019
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Primary progressive aphasia: a model for neurodegenerative disease.

Curr Opin Neurol 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurology, Memory and Aging Center.

Purpose Of Review: Knowledge on primary progressive aphasia (PPA) has expanded rapidly in the past few decades. Clinical characteristics, neuroimaging correlates, and neuropathological features of PPA are better delineated. This facilitates scientific studies on the disease pathophysiology and allows speech and language therapy to be more precisely targeted. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000673DOI Listing
January 2019
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Adjustment with aphasia after stroke: study protocol for a pilot feasibility randomised controlled trial for SUpporting wellbeing through PEeR Befriending (SUPERB).

Pilot Feasibility Stud 2019 22;5:14. Epub 2019 Jan 22.

6Biostatistics & Health Informatics Department, Division of Psychology and Systems Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.

Background: Despite the high prevalence of mood problems after stroke, evidence on effective interventions particularly for those with aphasia is limited. There is a pressing need to systematically evaluate interventions aiming to improve wellbeing for people with stroke and aphasia. This study aims to evaluate the feasibility of a peer-befriending intervention. Read More

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http://dx.doi.org/10.1186/s40814-019-0397-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341752PMC
January 2019
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Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report.

J Med Case Rep 2019 Jan 29;13(1):26. Epub 2019 Jan 29.

Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Background: Trousseau syndrome is known as a variant of cancer-associated thrombosis. Trousseau syndrome commonly occurs in patients with lung or prostate cancer. Hypercoagulability is thought to be initiated by mucins produced by the adenocarcinoma, which react with leukocyte and platelet selectins to form platelet-rich microthrombi. Read More

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http://dx.doi.org/10.1186/s13256-018-1833-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350311PMC
January 2019
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Neural networks for sentence comprehension and production: An ALE-based meta-analysis of neuroimaging studies.

Hum Brain Mapp 2019 Jan 28. Epub 2019 Jan 28.

Center for the Neurobiology of Language Recovery, Northwestern University, Evanston, Illinois.

Comprehending and producing sentences is a complex endeavor requiring the coordinated activity of multiple brain regions. We examined three issues related to the brain networks underlying sentence comprehension and production in healthy individuals: First, which regions are recruited for sentence comprehension and sentence production? Second, are there differences for auditory sentence comprehension vs. visual sentence comprehension? Third, which regions are specifically recruited for the comprehension of syntactically complex sentences? Results from activation likelihood estimation (ALE) analyses (from 45 studies) implicated a sentence comprehension network occupying bilateral frontal and temporal lobe regions. Read More

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http://dx.doi.org/10.1002/hbm.24523DOI Listing
January 2019
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Sentence Processing in Aphasia: An Examination of Material-Specific and General Cognitive Factors.

Authors:
Laura L Murray

J Neurolinguistics 2018 Nov 4;48:26-46. Epub 2018 Apr 4.

School of Communication Sciences and Disorders Western University.

The purpose of this study was to characterize further the nature of sentence processing deficits in acquired aphasia. Adults with aphasia and age-and education-matched adults with no brain damage completed a battery of formal cognitive-linguistic tests and an experimental sentence judgment task, which was performed alone and during focused attention and divided attention or dual-task conditions. The specific aims were to determine whether (a) increased extra-linguistic cognitive demands (i. Read More

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http://dx.doi.org/10.1016/j.jneuroling.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345386PMC
November 2018
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Recovery of Severe Aphasia After Cranioplasty: Considerations on a Case Study.

Rehabil Nurs 2019 Jan 23. Epub 2019 Jan 23.

IRCCS Centro Neurolesi "Bonino-Pulejo," Messina, Italy.

Cranioplasty is the main surgical intervention for repairing cranial defects performed in about 80% of the patients following cancer surgery or decompressive craniectomy. Although some works have shown recovery of motor and cognitive function, including memory, attention, and executive functions, until today no studies have focused on language recovery after cranioplasty. A 68-year-old woman came to the Neurorehabilitation Unit of the IRCCS Neurolesi (Messina, Italy) because of a fluent aphasia due to a severe left nucleocapsular hemorrhage and greatly improved her motor and neuropsychological status after cranioplasty. Read More

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http://dx.doi.org/10.1097/rnj.0000000000000212DOI Listing
January 2019
2 Reads