18,705 results match your criteria Aphasia

Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia.

Med Sci Monit 2021 May 10;27:e930100. Epub 2021 May 10.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

BACKGROUND Aphasia is a debilitating consequence of stroke. This study aimed to investigate the role of functional magnetic resonance imaging (fMRI) activation changes during overt language tasks in promoting language improvements following constraint-induced aphasia therapy (CIAT) primed with intermittent theta burst stimulation (iTBS) in 13 patients with aphasia following ischemic stroke. MATERIAL AND METHODS Participants with post-stroke aphasia participated in CIAT primed with iTBS on 10 consecutive weekdays. Read More

View Article and Full-Text PDF

Prognostication in post-stroke aphasia: speech pathologists' clinical insights on formulating and delivering information about recovery.

Disabil Rehabil 2021 May 8:1-14. Epub 2021 May 8.

School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Australia.

Purpose: For people with post-stroke aphasia, "Will I get better?" is a question often asked, but one that is intellectually and emotionally demanding for speech pathologists to answer. Speech pathologists' formulation and delivery of aphasia prognoses is varied and there is limited evidence for optimising practice. We aimed to understand speech pathologists' clinical experiences, reasoning, and support needs in aphasia prognostication. Read More

View Article and Full-Text PDF

Aphasia as the Initial Presentation of Acute Otomastoiditis in an Elderly Male.

Cureus 2021 Apr 5;13(4):e14293. Epub 2021 Apr 5.

Department of Pulmonary and Critical Care Medicine, Grand Strand Regional Medical Center, Myrtle Beach, USA.

Acute otomastoiditis is a potentially life-threatening condition. It is relatively uncommon in elderly patients and is usually seen as a complication of acute otitis media. Limited studies are available on this uncommon disease in the elderly, and thus the clinical course of the disease is not fully understood. Read More

View Article and Full-Text PDF

Semantic memory impairment in dementia: A cross-cultural adaptation study.

Neurol Sci 2021 May 8. Epub 2021 May 8.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India.

Background: Semantic memory deficits are frequently encountered in dementia and distinct patterns of semantic impairment characterize the subtypes of dementia. Life course and cultural experiences significantly influence semantic memory. Hence, there is a need to assess semantic memory using culturally appropriate tests, to aid accurate diagnosis of dementia and facilitate cross-cultural collaborative research. Read More

View Article and Full-Text PDF

Development of an online implementation intervention for aphasia clinicians to increase the intensity and comprehensiveness of their service.

Disabil Rehabil 2021 May 7:1-10. Epub 2021 May 7.

School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, Australia.

Purpose: To describe the process and outcome of a user and theory informed online intervention for speech pathologists targeting the implementation of intensive and comprehensive aphasia services.

Methods: The design process followed the eight steps outlined by the Behaviour Change Wheel and incorporated the principles of Integrated Knowledge Translation (IKT). Eight speech pathology researchers and clinicians from four countries (Australia, Canada, the United Kingdom and Ireland) contributed to three focus groups videoconference. Read More

View Article and Full-Text PDF

Tension pneumoventricle: Reversible cause for aphasia.

Qatar Med J 2021 23;2021(1):15. Epub 2021 Apr 23.

Department of Neurosurgery, Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.

Pneumocephalus is air in the cranium commonly seen in postcraniotomy and in head injury patients. When this air causes an increase in intracranial pressure leading to neurological deterioration, it is called tension pneumocephalus. Similarly, intraventricular air causing compression on vital centers and increasing intracranial pressure is called tension pneumoventricle, and this causes expressive aphasia, which is rarely described in the literature. Read More

View Article and Full-Text PDF

Comparing verbal and aided single sentence productions in Malayalam-speaking adults with aphasia: a preliminary investigation.

Clin Linguist Phon 2020 Dec 2:1-24. Epub 2020 Dec 2.

Department of Speech-Language Pathology, All India Institute of Speech and Hearing, Mysuru, Karnataka, India.

The primary aim of the study was to investigate the semantic and syntactic aspects of verbal and aided single sentence productions in adults with aphasia and neurotypical adults to determine which mode allowed the exchange of information more effectively. The participants of this study included 20 adults with aphasia and 20 neurotypical adults who were native speakers of Malayalam, an Indo-Dravidian language spoken in the south-western state of Kerala in India. Thirteen action picture stimuli were constructed to elicit single sentences. Read More

View Article and Full-Text PDF
December 2020

Three Cases of Aphasic Status Epilepticus: Clinical and Electrographic Characteristics.

Clin Med Insights Case Rep 2021 10;14:11795476211009241. Epub 2021 Apr 10.

Department of Neurology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea.

Aphasic status epilepticus (ASE) is unusual and has clinical characteristics similar to those of other disorders. Herein, we report 3 cases of ASE. A left-handed man (patient 1) showed continuous aphasia after the administration of flumazenil. Read More

View Article and Full-Text PDF

Hospital staff, volunteers' and patients' perceptions of barriers and facilitators to communication following stroke in an acute and a rehabilitation private hospital ward: a qualitative description study.

BMJ Open 2021 May 5;11(5):e043897. Epub 2021 May 5.

School of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, Australia.

Objectives: To explore barriers and facilitators to patient communication in an acute and rehabilitation ward setting from the perspectives of hospital staff, volunteers and patients following stroke.

Design: A qualitative descriptive study as part of a larger study which aimed to develop and test a Communication Enhanced Environment model in an acute and a rehabilitation ward.

Setting: A metropolitan Australian private hospital. Read More

View Article and Full-Text PDF

Sabina Spielrein's theory of the origin and development of language.

Fatima Caropreso

Int J Psychoanal 2020 Aug;101(4):706-723

Department of Psychology, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

In recent years, a growing acknowledgement of the importance and originality of Sabina Spielrein's theoretical and clinical work has taken place. However, few studies have been specifically devoted to a thorough analysis of her theory, so a satisfactory understanding of her thinking has not yet been fully achieved. The objective of this article is to contribute to the understanding of Spielrein's theory of language, based on the analysis of her two main papers on the subject, "The Origin of the Child's Words 'Papa' and 'Mama'" (1922) and "Some Analogies between the Thought of Children, Aphasia, and the Subconscious Thought" (1923). Read More

View Article and Full-Text PDF

Perfusion image guided mechanical thrombectomy combined with tirofiban successfully revascularize systemic lupus erythematosus related acute large vessel occlusion: A case report.

Medicine (Baltimore) 2021 May;100(18):e25779

Department of Neurological Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Rationale: Systemic lupus erythematosus (SLE) is an important cause of stroke, more than a half the cases present as acute ischemic stroke. Thrombolysis is an effective choice in most cases, but for large vessel occlusion, mechanical thrombectomy is more effective. Here we reported a case of SLE-related stroke with left middle cerebral artery (MCA) occlusion, who was successfully treated by MT and tirofiban. Read More

View Article and Full-Text PDF

EXPRESS: Treatment of post-stroke aphasia: A Narrative Review for Stroke Neurologists.

Int J Stroke 2021 May 5:17474930211017807. Epub 2021 May 5.

Johns Hopkins University School of Medicine, Neurology, Phipps 446, Baltimore, Maryland, United States.

This review is intended to help physicians guide patients to optimal management of post-stroke aphasia. We review literature on post-stroke aphasia treatment, focusing on: (1) when and for whom language therapy is most effective, (2) the variety of approaches that can be effective for different individuals, and (3) the extent to which behavioral therapy might be augmented by non-invasive brain stimulation and/or medications. Read More

View Article and Full-Text PDF

Uncrossed corticospinal tract in health and genetic disorders: Review, case report and clinical implications.

Eur J Neurol 2021 May 5. Epub 2021 May 5.

University Hospital of the LMU Munich, Department of Neurology, Marchioninistr. 15, 81377, Munich, Germany.

Background: Crossing pathologies of the corticospinal tract (CST) are rare and often associated with genetic disorders. However, they can be present in healthy humans and lead to ipsilateral motor deficits when a lesion to motor areas occurs. Here we review historical and current literature of CST crossing pathologies and present a rare case of asymmetric crossing of the CST. Read More

View Article and Full-Text PDF

Osteosarcoma of the temporal bone occurring 40 years after radiotherapy: A technical case report presenting resection of intra- and extracranial lesions followed by a one-stage reconstruction.

Surg Neurol Int 2021 14;12:152. Epub 2021 Apr 14.

Department of Pathology, Harasanshin Hospital, Hakata-ku, Fukuoka, Japan.

Background: Osteosarcoma (OS) is a malignant tumor of the bone, which rarely occurs in the head-and-neck regions as a primary or a secondary malignancy. Adequate surgical resection is currently the mainstay of treatment for head-and-neck OS; however, resection and reconstruction can be difficult because the anatomies of these regions are complex. We present a case of an OS arising from the temporal bone 40 years after radiation therapy, which was successfully treated with resection and a one-stage reconstruction using intraoperative tissue expansion technique. Read More

View Article and Full-Text PDF

Progressive apraxia of speech: delays to diagnosis and rates of alternative diagnoses.

J Neurol 2021 May 4. Epub 2021 May 4.

Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Background: Progressive apraxia of speech (PAOS) is a neurodegenerative disorder of speech programming distinct from aphasia and dysarthria, most commonly associated with a 4-repeat tauopathy. Our objective was to better understand the reasons for possible delays or diagnostic errors for patients with PAOS.

Methods: Seventy-seven consecutive PAOS research participants from the Neurodegenerative Research Group were included in this study. Read More

View Article and Full-Text PDF

Efficacy and safety of lacosamide in the treatment of status epilepticus in a patient with comorbidities.

Acta Biomed 2021 Apr 30;92(S1):e2021090. Epub 2021 Apr 30.

UOC Neurologia, Department of Systems Medicine, University of Tor Vergata.

Efficacy, safety and tolerability of lacosamide in the treatment of status epilepticus are well described. However, other evidence of its pharmacologic profile in elderly patients with other comorbidities seems warranted. We describe the case of an 80 year-old woman with an history of arterial hypertension, ischemic cardiomyopathy, COPD, CKD, previous laryngeal cancer, a stoma positioning for diverticular disease and previous surgery for a left frontal meningioma. Read More

View Article and Full-Text PDF

COVID-19-Associated Ischemic Stroke in a Patient on Therapeutic Anticoagulation.

Neurologist 2021 May 5;26(3):108-111. Epub 2021 May 5.

Medicine, University of Florida College of Medicine, Jacksonville, FL.

Introduction: The coronavirus disease 2019 (COVID-19) has been associated with a hypercoagulable state, increasing the risk for ischemic stroke. In select cases, patients are already on anticoagulation therapy. Such examples highlight the severity of COVID-19's hyperthrombotic state, and raise questions regarding optimal stroke prevention in these patients. Read More

View Article and Full-Text PDF

Motor speech disorders in the nonfluent, semantic and logopenic variants of primary progressive aphasia.

Cortex 2021 Apr 2;140:66-79. Epub 2021 Apr 2.

Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technische Universität München, München, Germany; Munich Cluster for Systems Neurology (SyNergy), München, Germany.

Objective: Motor speech disorders (MSDs) are characteristic for nonfluent primary progressive aphasia (nfvPPA). In primary progressive aphasia (PPA) of the semantic (svPPA) and of the logopenic type (lvPPA), speech motor function is considered typically intact. However, knowledge on the prevalence of MSDs in svPPA and lvPPA is mainly based on studies with a priori knowledge of PPA syndrome diagnosis. Read More

View Article and Full-Text PDF

Using concept typicality to explore semantic representation and control in healthy ageing.

Cogn Process 2021 Apr 29. Epub 2021 Apr 29.

Faculdade de Psicologia, Research Center for Psychological Science, Universidade de Lisboa, Alameda da Universidade, 1649-013, Lisboa, Portugal.

Successful use of conceptual knowledge entails the assembling of semantic representations and control processes to access the subsets of knowledge relevant in each situation. Research has suggested that representation and control mechanisms interact to support categorization. Notably, depleted representations in semantic dementia and disrupted control processes in semantic aphasia impair categorization of atypical concepts. Read More

View Article and Full-Text PDF

Lesions that do or do not impair digit span: a study of 816 stroke survivors.

Brain Commun 2021 10;3(2):fcab031. Epub 2021 Mar 10.

Wellcome Centre for Human Neuroimaging, University College London, London WC1N 3AR, UK.

Prior studies have reported inconsistency in the lesion sites associated with verbal short-term memory impairments. Here we asked: How many different lesion sites can account for selective impairments in verbal short-term memory that persist over time, and how consistently do these lesion sites impair verbal short-term memory? We assessed verbal short-term memory impairments using a forward digit span task from the Comprehensive Aphasia Test. First, we identified the incidence of digit span impairments in a sample of 816 stroke survivors (541 males/275 females; age at stroke onset 56 ± 13 years; time post-stroke 4. Read More

View Article and Full-Text PDF

Yonder: Travellers, obstructive sleep apnoea, sex workers, and post-stroke aphasia.

Ahmed Rashid

Br J Gen Pract 2021 May 29;71(706):227. Epub 2021 Apr 29.

GP and Clinical Associate Professor, UCL Medical School, UCL, London. Email:

View Article and Full-Text PDF

Defining Hypoperfusion in Chronic Aphasia: An Individualized Thresholding Approach.

Brain Sci 2021 Apr 13;11(4). Epub 2021 Apr 13.

San Diego State University and University of California San Diego Joint Doctoral Program in Language and Communicative Disorders, San Diego, CA 92182, USA.

Within the aphasia literature, it is common to link location of lesioned brain tissue to specific patterns of language impairment. This has provided valuable insight into the relationship between brain structure and function, but it does not capture important underlying alterations in function of regions that remain structurally intact. Research has demonstrated that in the chronic stage of aphasia, variable patterns of reduced cerebral blood flow (CBF; hypoperfusion) in structurally intact regions of the brain contribute to persisting language impairments. Read More

View Article and Full-Text PDF

Cerebral Toxoplasmosis, CMV and Bacterial Pneumonia with Decreasing CD4+ T-Cell Count as Results of Antiretroviral Therapy Discontinuation-A Case Report.

Pathogens 2021 Apr 20;10(4). Epub 2021 Apr 20.

The Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, Wolska 37 Street, 01-201 Warsaw, Poland.

Cerebral toxoplasmosis occurs mainly in immunocompromised hosts as a reactivation of latent infection. In the diagnostic process, magnetic resonance imaging (MRI), serum testing, and biopsy are used. We describe a case of a 43-year-old HIV-positive patient presenting with altered levels of consciousness, aphasia, and hemiparesis. Read More

View Article and Full-Text PDF

DUAL-tDCS Treatment over the Temporo-Parietal Cortex Enhances Writing Skills: First Evidence from Chronic Post-Stroke Aphasia.

Life (Basel) 2021 Apr 14;11(4). Epub 2021 Apr 14.

Department of Humanities Studies, University Federico II, 80133 Naples, Italy.

The learning of writing skills involves the re-engagement of previously established independent procedures. Indeed, the writing deficit an adult may acquire after left hemispheric brain injury is caused by either an impairment to the lexical route, which processes words as a whole, to the sublexical procedure based on phoneme-to-grapheme conversion rules, or to both procedures. To date, several approaches have been proposed for writing disorders, among which, interventions aimed at restoring the sub-lexical procedure were successful in cases of severe agraphia. Read More

View Article and Full-Text PDF

Thrombocytopenia and Intracranial Venous Sinus Thrombosis after "COVID-19 Vaccine AstraZeneca" Exposure.

J Clin Med 2021 Apr 9;10(8). Epub 2021 Apr 9.

Neuroradiologische Klinik, Klinikum Stuttgart, D-70174 Stuttgart, Germany.

Background: As of 8 April 2021, a total of 2.9 million people have died with or from the coronavirus infection causing COVID-19 (Corona Virus Disease 2019). On 29 January 2021, the European Medicines Agency (EMA) approved a COVID-19 vaccine developed by Oxford University and AstraZeneca (AZD1222, ChAdOx1 nCoV-19, COVID-19 vaccine AstraZeneca, Vaxzevria, Covishield). Read More

View Article and Full-Text PDF

German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia.

Brain Sci 2021 Apr 8;11(4). Epub 2021 Apr 8.

Department of Neurology, University Medical Center Freiburg, Breisacherstrasse 64, 79106 Freiburg, Germany.

Grammar provides the framework for understanding and producing language. In aphasia, an acquired language disorder, grammatical deficits are diversified and widespread. However, the few assessments for testing grammar in the German language do not consider current linguistic, psycholinguistic, and functional imaging data, which have been shown to be crucial for effective treatment. Read More

View Article and Full-Text PDF

F-THK-5351, Fluorodeoxyglucose, and Florbetaben PET Images in Atypical Alzheimer's Disease: A Pictorial Insight into Disease Pathophysiology.

Brain Sci 2021 Apr 6;11(4). Epub 2021 Apr 6.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

The recent advance of positron emission tomography (PET) tracers as biomarkers in Alzheimer's disease (AD) provides more insight into pathophysiology, preclinical diagnosis, and further therapeutic strategies. However, synergistic processes or interactions between amyloid and tau deposits are still poorly understood. To better understand their relationship in focal brain changes with clinical phenotypes, we focused on region-specific or atypical AD characterized by focal clinical presentations: Posterior cortical atrophy (PCA) and logopenic variant of primary progressive aphasia (lpvPPA). Read More

View Article and Full-Text PDF

Performance Evaluation of Machine Learning Frameworks for Aphasia Assessment.

Sensors (Basel) 2021 Apr 7;21(8). Epub 2021 Apr 7.

Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515041, China.

Speech assessment is an essential part of the rehabilitation procedure for patients with aphasia (PWA). It is a comprehensive and time-consuming process that aims to discriminate between healthy individuals and aphasic patients, determine the type of aphasia syndrome, and determine the patients' impairment severity levels (these are referred to here as aphasia assessment tasks). Hence, the automation of aphasia assessment tasks is essential. Read More

View Article and Full-Text PDF

Performance of Korean-English bilinguals on an adaptation of the screening bilingual aphasia test.

Int J Lang Commun Disord 2021 Apr 29. Epub 2021 Apr 29.

Department of Hearing and Speech Sciences, University of Maryland, College Park, MD, USA.

Background: The use of standardized tests specifically designed for and normed on bilingual groups is crucial for the accurate diagnosis and language profiling of bilingual speakers with aphasia. Currently, there is a dearth of norms and supporting psychometric data for the few available bilingual aphasia assessments. The only available aphasia test for Korean-English (KE) bilinguals is the Korean-English Bilingual Aphasia Test (KE-BAT). Read More

View Article and Full-Text PDF

Hypoglossal Nerve Paraganglioma Depicting as Glomus Tumor of Neck.

Iran J Otorhinolaryngol 2021 Mar;33(115):113-117

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan .

Introduction: Paraganglioma are infrequent neuroendocrine tumors that are most commonly found in the carotid body, ganglia of the vagus, jugular and tympanic nerve. Very rarely they can involve other cranial nerves outside the cranial cavity, we present one such case of hypoglossal nerve paraganglioma in neck.

Case Report: A 48 years old male presented with 1-month history of right sided stroke and aphasia. Read More

View Article and Full-Text PDF