16,783 results match your criteria Aphasia


Distal Thrombectomy for Acute Anterior Circulation Stroke with Chronic Large Vessel Occlusion.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, Shandong, China. Electronic address:

Background: Endovascular therapy has been increasingly recommended for the treatment of acute ischemic stroke with large vessel occlusion of the anterior circulation. However, occlusions of the distal cerebral artery are not uncommon and may cause clinical deficits, especially when combined with ipsilateral chronic large vessel occlusion. Therefore, in this patient population, the recognition of chronic occlusion and recanalization of the distal occlusive artery might be of great value for flow compensation. Read More

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December 2018

[Speech and Language Disorders in the Elderly].

Authors:
Arno Olthoff

Laryngorhinootologie 2018 Dec 10;97(12):846-851. Epub 2018 Dec 10.

Phoniatrie und Pädaudiologie Göttingen, Klinik für Hals-, Nasen- und Ohrenheilkunde.

Cerebrovascular insults and neurodegenerative diseases are the main causes of acquired speech and language disorders. A massive increase in the prevalence of both is evident from the age of 65 years. By the age of 90 years, more than 10 % of the population would have experienced a stroke and 30 % would have suffered from neurodegenerative diseases. Read More

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December 2018

Spontaneously remitting insulin autoimmune syndrome in a patient taking alpha-lipoic acid.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Insulin autoimmune syndrome (IAS), or Hirata disease, is a rare hypoglycaemic disorder caused by the presence of high titer of insulin autoantibodies (IAA) in patients without previous exposure to exogenous insulin. Even though its pathogenesis is not fully understood, striking evidences link IAS to previous exposure to sulphydryl-containing medications, like alpha-lipoic acid, a widely used nutritional supplement. Although challenging, a careful differential diagnosis from other causes of hyperinsulinaemic hypoglycaemia (such as insulinoma) is mandatory, since these conditions require different therapeutic approaches. Read More

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December 2018
1 Read

Quality of Communication Life in Individuals with Broca's Aphasia and Normal Individuals: A Comparative Study.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):285-289

Department of Speech, Language and Hearing Sciences, Sri Ramachandra Medical College and Research Institute (Deemed University), Chennai, Tamil Nadu, India.

Background: Aphasia is a neurogenic communication disorder with significant deficits in various domains of language and communication. One such type of aphasia, which impacts the quality of life significantly is Broca's aphasia, where the individual is aware of the communication difficulty.

Objective: To compare the Quality of Communication Life (QoCL) between individuals with Broca's aphasia and normal individuals. Read More

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December 2018

Posterior reversible encephalopathy syndrome.

Curr Opin Neurol 2018 Dec 10. Epub 2018 Dec 10.

Center for Stroke Research Berlin (CSB).

Purpose Of Review: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterized by acute cerebral endotheliopathy with consecutive disruption of the blood-brain barrier and vasogenic edema. Since its first description in 1996, PRES is increasingly recognized. However, many aspects of this syndrome with its wide spectrum of clinical and radiological features are still incompletely understood. Read More

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December 2018

Prepositions and pronouns in connected discourse of individuals with aphasia.

Clin Linguist Phon 2018 Dec 11:1-21. Epub 2018 Dec 11.

a Department of Nordic Studies and Linguistics , University of Copenhagen , Copenhagen , Denmark.

The lexical-grammatical divide has been a widely addressed topic in aphasia. Speech parts are generally classified as either belonging to a lexical or a grammatical category based on the frequency of acquisition of new members in their paradigms (open vs. closed classes), thus neglecting heterogeneity within categories. Read More

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December 2018

A meta-analysis of neuropsychological, social cognitive, and olfactory functioning in the behavioral and language variants of frontotemporal dementia.

Psychol Med 2018 Dec 6:1-12. Epub 2018 Dec 6.

Department of Psychiatry and Behavioral Sciences,Baltimore, MD,USA.

Background: Though meta-analyses of neuropsychological and social cognitive deficits in behavioral variant frontotemporal dementia (bvFTD) have been conducted, no study has comprehensively characterized and compared the neuropsychological, social cognitive, and olfactory profiles in the behavioral and language variants of FTD.

Methods: Our search yielded 470 publications meeting inclusion criteria representing 11 782 FTD patients and 19 451 controls. For each domain, we calculated Hedges' g effect sizes, which represent the mean difference between the patient and control group divided by the pooled standard deviation. Read More

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December 2018
1 Read

The applause sign in frontotemporal lobar degeneration and related conditions.

J Neurol 2018 Dec 1. Epub 2018 Dec 1.

Neurologische Klinik und Poliklinik, Ludwig Maximilians Universität München, Munich, Germany.

The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP). Read More

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December 2018

Value-Based Stroke Rehabilitation: Feasibility and Results of Patient-Reported Outcome Measures in the First Year After Stroke.

J Stroke Cerebrovasc Dis 2018 Nov 29. Epub 2018 Nov 29.

Rijnlands Rehabilitation Centre, Leiden, The Netherlands; Sophia Rehabilitation Centre, The Hague, The Netherlands; Department of Orthopaedics, Leiden University Medical Center, Rehabilitation, and Physical Therapy, Leiden, The Netherlands.

Purpose: Structured application of patient-reported outcome measures (PROMs) is a key element in Value Based Healthcare. This study aimed to evaluate the feasibility of a broad set of PROMs reflecting similar patient reported health domains as proposed within the International Standard Set of Patient-Centered Outcome Measures After Stroke within the first year after stroke.

Methods: The study included consecutive stroke patients admitted to inpatient or outpatient specialized rehabilitation. Read More

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November 2018

The Relationship Between Non-Orthographic Language Abilities and Reading Performance in Chronic Aphasia: An Exploration of the Primary Systems Hypothesis.

J Speech Lang Hear Res 2018 Dec;61(12):3038-3054

Department of Speech & Hearing Sciences, University of Washington, Seattle.

Purpose: This study investigated the relationship between non-orthographic language abilities and reading in order to examine assumptions of the primary systems hypothesis and further our understanding of language processing poststroke.

Method: Performance on non-orthographic semantic, phonologic, and syntactic tasks, as well as oral reading and reading comprehension tasks, was assessed in 43 individuals with aphasia. Correlation and regression analyses were conducted to determine the relationship between these measures. Read More

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December 2018

Modifying and Validating a Measure of Chronic Stress for People With Aphasia.

J Speech Lang Hear Res 2018 Dec;61(12):2934-2949

Department of Speech and Hearing Sciences, University of Washington, Seattle.

Purpose: Chronic stress is likely a common experience among people with the language impairment of aphasia. Importantly, chronic stress reportedly alters the neural networks central to learning and memory-essential ingredients of aphasia rehabilitation. Before we can explore the influence of chronic stress on rehabilitation outcomes, we must be able to measure chronic stress in this population. Read More

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December 2018
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Accessibility and Applicability of Currently Available e-Mental Health Programs for Depression for People With Poststroke Aphasia: Scoping Review.

J Med Internet Res 2018 Dec 4;20(12):e291. Epub 2018 Dec 4.

Discipline of Clinical Psychology, Graduate School of Health, University of Technology, Sydney, Ultimo, Australia.

Background: Depression affects approximately 60% of people with aphasia 1 year post stroke and is associated with disability, lower quality of life, and mortality. Web-delivered mental health (e-mental health) programs are effective, convenient, and cost-effective for the general population and thus are increasingly used in the management of depression. However, it is unknown if such services are applicable and communicatively accessible to people with poststroke aphasia. Read More

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December 2018
1 Read

HaNDL Syndrome: Case Report and Literature Review.

J Child Neurol 2018 Dec 5:883073818811546. Epub 2018 Dec 5.

1 Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.

Headache and Neurologic Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome is a rare stroke mimicker characterized by moderate to severe headache temporally associated with transient neurologic deficits, typically hemiparesis, hemisensory disturbance, and/or aphasia. Cerebrospinal fluid studies reveal a lymphocytosis and elevated protein. Episodes recur over a period no longer than 3 months. Read More

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December 2018

Understanding spoken language through TalkBank.

Authors:
Brian MacWhinney

Behav Res Methods 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.

Ongoing advances in computer technology have opened up a deluge of new datasets for understanding human behavior (Goldstone & Lupyan, 2016). Many of these datasets provide information on the use of written language. However, data on naturally occurring spoken-language conversations are much more difficult to obtain. Read More

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December 2018
4 Reads

Identification of a novel mutation in gene in a Thai subject with early-onset Alzheimer's disease.

Neuropsychiatr Dis Treat 2018 8;14:3015-3023. Epub 2018 Nov 8.

Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam, South Korea,

Introduction: Early-onset Alzheimer's disease (AD) accounts for than less 1% of all AD cases, with large variation in the reported genetic contributions of known dementia genes. Mutations in the amyloid precursor protein () gene were the first to be recognized as the cause of AD.

Methods: Here, a male patient with probable early-onset AD at the age of 55 years from Thailand was investigated by next-generation sequencing. Read More

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November 2018

Blood-Based Kinase Assessments in Alzheimer's Disease.

Front Aging Neurosci 2018 14;10:338. Epub 2018 Nov 14.

Center of Cognitive Neurology, Lariboisiere Fernand-Widal Hospital, APHP, University Paris Diderot, Paris, France.

Alzheimer's disease (AD) is marked by memory disturbances followed by aphasia, apraxia and agnosia. Brain lesions include the accumulation of the amyloid peptide in extracellular plaques, neurofibrillary tangles with abnormally phosphorylated tau protein and synaptic and neuronal loss. New findings have suggested that brain lesions could occur one or two decades before the first clinical signs. Read More

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November 2018

[Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody].

Rinsho Shinkeigaku 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.

A 27-year-old man developed acute encephalitis with headache, fever, seizures, and aphasia. Analysis of cerebrospinal fluid showed elevated levels of cell counts and protein. A brain MRI demonstrated increased FLAIR signals in the left cerebral cortex with cortical swelling. Read More

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November 2018
1 Read

Word-level prosodic measures and the differential diagnosis of apraxia of speech.

Clin Linguist Phon 2018 Nov 28:1-17. Epub 2018 Nov 28.

a Department of Allied Health Sciences , University of North Carolina at Chapel Hill School of Medicine , Chapel Hill , NC , USA.

Impaired production of prosody is considered a primary diagnostic criterion for apraxia of speech. In this study, we examined diagnostic relevance for five word-level prosody measures. Seven speakers with AOS, nine with aphasia and no AOS, and 19 age-matched neurotypical controls produced nine words consisting of three or four syllables. Read More

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November 2018

Clinical presentation, risk factors and outcome of central nervous system metastasis vs stroke in cancer patients.

Curr Probl Cancer 2018 Nov 16. Epub 2018 Nov 16.

Neuro-oncology Unit, Research Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.

Background And Purpose: Cancer and stroke are the second and third causes of death worldwide; brain metastases (BM) occur in one third of patients with cancer, any neurologic deficit in these population always prompts the clinician to discard metastases for their presence carries a bad outcome. Both might share clinical presentation and differences in their outcome are not entirely known. The aim was to compare risk factors, clinical presentation, and outcome of cancer patients with BM vs stroke. Read More

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November 2018
1 Read

Identification of Affective State Change in Adults With Aphasia Using Speech Acoustics.

J Speech Lang Hear Res 2018 Dec;61(12):2906-2916

Department of Population Health Sciences, University of Utah, Salt Lake City.

Purpose: The current study aimed to identify objective acoustic measures related to affective state change in the speech of adults with post-stroke aphasia.

Method: The speech of 20 post-stroke adults with aphasia was recorded during picture description and administration of the Western Aphasia Battery-Revised (Kertesz, 2006). In addition, participants completed the Self-Assessment Manikin (Bradley & Lang, 1994) and the Stress Scale (Tobii Dynavox, 1981-2016) before and after the language tasks. Read More

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December 2018
1 Read

The Dépistage Cognitif de Québec: A New Clinician's Tool for Early Recognition of Atypical Dementia.

Dement Geriatr Cogn Disord 2018 Nov 27;46(5-6):310-321. Epub 2018 Nov 27.

Clinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, CHU de Québec, Faculté de médecine, Université Laval, Québec, Québec,

Introduction: Early recognition of atypical dementia remains challenging partly because of lack of cognitive screening instruments precisely tailored for this purpose.

Methods: We assessed the validity and reliability of the Dépistage Cognitif de Québec (DCQ; www.dcqtest. Read More

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November 2018
2 Reads

Deciphering the mechanisms of phonological therapy in jargon aphasia.

Int J Lang Commun Disord 2018 Nov 26. Epub 2018 Nov 26.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK.

Background: Severe word production difficulties remain one of the most challenging clinical symptoms to treat in individuals with jargon aphasia. Clinically, it is important to determine why some individuals with jargon aphasia improve following therapy when others do not. We report a therapy study with AM, an individual with severe neologistic jargon aphasia, and provide a subsequent comparison with previous cases, with the purpose of informing both our theoretical and clinical understanding of jargon aphasia. Read More

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November 2018

Early Detection of Cerebral Infarction With Middle Cerebral Artery Occlusion With Functional Near-Infrared Spectroscopy: A Pilot Study.

Front Neurol 2018 8;9:898. Epub 2018 Nov 8.

Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea.

NIRSIT, a functional near-infrared spectroscopy (fNIRS) device with 204 channels, can measure oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) in non-pulsatile blood flow non-invasively using the absorption difference between HbO2 and HbR at a wavelength of 700-1,000 nm and can display the perfusion status in real time. We applied NIRSIT to patients with stroke to evaluate the usefulness of NIRSIT as an fNIRS device for the early detection of stroke. We performed a prospective pilot study in an emergency department (ED). Read More

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November 2018
5 Reads

Discourse recovery after severe traumatic brain injury: exploring the first year.

Brain Inj 2018 Nov 22:1-17. Epub 2018 Nov 22.

a Faculty of Health Sciences , The University of Sydney , Lidcombe , Australia.

Objectives: Although much is known about discourse impairment, little is known about discourse recovery after severe traumatic brain injury (TBI). This paper explores discourse recovery across the critical first year, controlling for pre-injury, injury and post-injury variables.

Design And Methods: An inception cohort comprising 57 participants with severe TBI was examined at 3, 6, 9 and 12 months post-injury and compared to a cross-section of matched healthy control participants. Read More

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November 2018
3 Reads

Role of Diffusion-weighted Imaging in Detecting Early Ischemic Brain Injury Following Aneurysmal Subarachnoid Hemorrhage.

Asian J Neurosurg 2018 Oct-Dec;13(4):1074-1077

Department of Neurosurgery, SMS Hospital, Jaipur, Rajasthan, India.

Background: Aneurysmal SAH is the significant cause of morbidity and mortality in stroke patients. Early brain injury and delayed cerebral ischemia are the two main responsible pathophysiologic processes. Cerebral ischemia needs to be detected early so that early aggressive therapy could be started. Read More

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November 2018
2 Reads

Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech.

Am J Speech Lang Pathol 2018 Nov;27(4):1303-1318

Department of Neurology, Mayo Clinic, Rochester, MN.

Purpose: This case series details the clinical progression of patients with primary progressive apraxia of speech (PPAOS) to illustrate, using several methods and supplemental material examples, the changes that occur in speech and language functioning in this patient population.

Method: Four patients who presented with PPAOS were followed between 5 and 6 years. Two patients had predominant articulatory abnormalities (termed phonetic PPAOS), 1 had predominant prosodic abnormalities (prosodic PPAOS), and 1 had relatively equal articulatory and prosodic abnormalities (mixed PPAOS). Read More

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November 2018
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An Integrative Analysis of Spontaneous Storytelling Discourse in Aphasia: Relationship With Listeners' Rating and Prediction of Severity and Fluency Status of Aphasia.

Am J Speech Lang Pathol 2018 Nov;27(4):1491-1505

Department of Special Education and Counselling, The Education University of Hong Kong.

Purpose: This study investigated which of the three analytic approaches of oral discourse, including linguistically based measures, proposition-based measures, and story grammar, best correlated with aphasia severity and with naïve listeners' ratings on aphasic productions. The predictive power of these analytic approaches to aphasia severity and fluency status of people with aphasia (PWA) was examined. Finally, which approach best discriminated fluent versus nonfluent PWA was determined. Read More

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November 2018
7 Reads

Prospective assessment of patients with stroke in Tikur Anbessa Specialised Hospital, Addis Ababa, Ethiopia.

Afr J Emerg Med 2018 Mar 16;8(1):21-24. Epub 2017 Dec 16.

NYMC, Metropolitan Hospital Center, Department of Emergency Medicine, United States.

Introduction: The burden of stroke is increasing in many low- and middle-income countries. In Ethiopia, stroke has become a major cause of morbidity, long-term disability, and mortality. Time from stroke onset to hospital presentation is a critical factor in acute stroke care. Read More

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March 2018
5 Reads

Short-term memory span in aphasia: Insights from speech-timing measures.

J Neurolinguistics 2018 Nov 4;48:176-189. Epub 2018 May 4.

Temple University, Department of Communication Sciences & Disorders, Ritter Annex, 1301 Cecil B Moore Avenue, Philadelphia, PA 19122, USA, +1 215 204 1870.

Auditory-verbal short-term memory impairments are part and parcel of aphasia and interfere with linguistic processing. To date, the science about short-term memory impairments in aphasia has been generated and dominated by studying measures of accuracy, that is, span length. Because accuracy is expressed through speech, examining the speech-timing characteristics of persons with aphasia as they engage in spoken recall could reveal insights about the manner in which accuracy is achieved. Read More

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November 2018
1 Read

The Intensive Cognitive-Communication Rehabilitation Program for Young Adults With Acquired Brain Injury.

Am J Speech Lang Pathol 2018 Nov 16:1-18. Epub 2018 Nov 16.

Aphasia Research Laboratory, Speech and Hearing Sciences, Boston University, MA.

Purpose: This study investigated the effects of an intensive cognitive-communication rehabilitation (ICCR) program for young individuals with chronic acquired brain injury.

Method: ICCR included classroom lectures; metacognitive instruction, modeling, and application; technology skills training; and individual cognitive-linguistic therapy. Four individuals participated in the intensive program (6 hr with 1-hr lunch break × 4 days × 12 weeks of treatment): 3 participants completed 3 consecutive semesters, and 1 participant completed 1 semester. Read More

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November 2018
1 Read

Enriching Communicative Environments: Leveraging Advances in Neuroplasticity for Improving Outcomes in Neurogenic Communication Disorders.

Am J Speech Lang Pathol 2018 Nov 16:1-14. Epub 2018 Nov 16.

Department of Psychology, The University of Texas at Austin.

Purpose: Research manipulating the complexity of housing environments for healthy and brain-damaged animals has offered strong, well-replicated evidence for the positive impacts in animal models of enriched environments on neuroplasticity and behavioral outcomes across the lifespan. This article reviews foundational work on environmental enrichment from the animal literature and considers how it relates to a line of research examining rich communicative environments among adults with aphasia, amnesia, and related cognitive-communication disorders.

Method: Drawing on the authors' own research and the broader literature, this article first presents a critical review of environmental complexity from the animal literature. Read More

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November 2018
2 Reads

Psychometric properties of the Chinese-version Stroke and Aphasia Quality of Life Scale 39-generic version (SAQOL-39g).

Top Stroke Rehabil 2018 Nov 19:1-7. Epub 2018 Nov 19.

c Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine , The Chinese University of Hong Kong , Shatin , Hong Kong.

Background And Purpose: Aphasia is a common outcome of stroke affecting one-third of the post-stroke population in China. While the quality of life (QOL) may be affected, care is often inadequately guided due to lack of validated measure for Chinese population with stroke-induced aphasia. This study aimed to develop a Chinese-version of the Stroke and Aphasia Quality of Life-39 generic version (SAQOL-39g) and evaluate its feasibility, reliability, and validity in Chinese patients with stroke-induced aphasia. Read More

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November 2018
4 Reads

The Brain Donation Program in South Korea.

Yonsei Med J 2018 Dec;59(10):1197-1204

Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.

Purpose: Obtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. Read More

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December 2018
8 Reads

Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead.

Front Neurosci 2018 2;12:798. Epub 2018 Nov 2.

Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.

Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer's disease. While they are individually rarer, a range of other disorders, the tauopathies (including Pick's disease, progressive supranuclear palsy, corticobasal degeneration, primary progressive aphasia, and ∼50% of behavioral variant frontotemporal dementia cases) display pronounced underlying tau pathology. In all cases, the distribution and amount of tau pathology closely correlates with the severity and phenotype of cognitive impairment, and with the pattern and degree of brain atrophy. Read More

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November 2018
3 Reads

Surgical Management of Brainstem Cavernous Malformation: Report of 67 Patients.

World Neurosurg 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China. Electronic address:

Background: Brainstem CMs are benign lesions, often show an acute onset, and result in a high rate of morbidity. Surgical resection could inhibit the progressive deterioration of the neurological function caused by repetitive hemorrhage. This study aimed to summarize the timing, approaches, and techniques of surgery, and to evaluate the outcomes of treatment. Read More

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November 2018
6 Reads

Chronic subdural hematoma - review article.

Rozhl Chir 2018 ;97(6):253-257

Introduction: Chronic subdural hematoma (ChSDH) is, by definition, a subdural collection of blood older than 21 days. It is not exceptional that ChSDH is diagnosed in regional hospitals and thus we believe that basic knowledge on this topic is relevant for every general surgeon. Below, we summarize information on ChSDH and present simple clinical management guidelines. Read More

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January 2018
7 Reads

Efficacy of a self-administered treatment using a smart tablet to improve functional vocabulary in post-stroke aphasia: a case-series study.

Int J Lang Commun Disord 2018 Nov 14. Epub 2018 Nov 14.

Département de réadaptation, Université Laval, Quebec, QC, Canada.

Background: Aphasia is an acquired language disorder that occurs secondary to brain injury, such as stroke. It causes communication difficulties that have a significant impact on quality of life and social relationships. Although the efficacy of speech-language therapy has been clearly demonstrated in this population, long-term services are currently limited due to logistical and financial constraints. Read More

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November 2018
2 Reads

Measuring word retrieval in narrative discourse: core lexicon in aphasia.

Int J Lang Commun Disord 2018 Nov 14. Epub 2018 Nov 14.

Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC, USA.

Background: Discourse analysis procedures are time consuming and impractical in a clinical setting. Critical to clinicians are simple and informative discourse measures that require minimal time and labour to complete. Many studies, however, have overlooked difficulties that clinicians face. Read More

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November 2018
10 Reads

The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia.

Front Aging Neurosci 2018 30;10:346. Epub 2018 Oct 30.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Despite the common assumption that atrophy in a certain brain area would compromise the function that it subserves, this is not always the case, especially in complex clinical syndromes such as primary progressive aphasia (PPA). Clinical and demographic information may contribute to PPA phenotypes and explain the manifested impairments better than atrophy. In the present study, we asked how much variance of the object and action naming impairments observed in PPA may be attributed to atrophy in the language network alone vs. Read More

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October 2018
3 Reads

A Review: Mealtime Difficulties following Frontotemporal Lobar Degeneration.

Dement Geriatr Cogn Disord 2018 Nov 13;46(5-6):285-297. Epub 2018 Nov 13.

Centre for Neuroscience of Speech, The University of Melbourne, Melbourne, Victoria,

Background: Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common and significant outcome of FTLD. Disturbances during mealtimes can arise from dysphagia or may occur secondary to behavioral changes such as rapid eating, mealtime rigidity, and altered diet preferences. Read More

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November 2018
2 Reads

Fluid biomarkers for frontotemporal dementias.

Neuropathol Appl Neurobiol 2018 Nov 13. Epub 2018 Nov 13.

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Frontotemporal dementias (FTDs) are clinically, genetically and pathologically heterogeneous neurodegenerative disorders that affect the frontal and anterior temporal lobes of the brain. They are relatively common causes of young-onset dementia and usually present with behavioural disturbance (behavioural variant FTD) or language impairment (primary progressive aphasia), but there is also overlap with motor neurone disease and the atypical parkinsonian disorders, corticobasal syndrome and progressive supranuclear palsy. At post mortem, neuronal inclusions containing tau, TDP-43 or infrequently FUS protein are seen in most cases. Read More

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November 2018
6 Reads

Spontaneous oscillatory markers of cognitive status in two forms of dementia.

Hum Brain Mapp 2018 Nov 12. Epub 2018 Nov 12.

Rotman Research Institute, Baycrest Health Sciences Centre, Toronto, Ontario, Canada.

Abnormal oscillatory brain activity in dementia may indicate incipient neuronal/synaptic dysfunction, rather than frank structural atrophy. Leveraging a potential link between the degree of abnormal oscillatory activity and cognitive symptom severity, one could localize brain regions in a diseased but pre-atrophic state, which may be more amenable to interventions. In the current study, we evaluated the relationships among cognitive deficits, regional volumetric changes, and resting-state magnetoencephalography abnormalities in patients with mild cognitive impairment (MCI; N = 10; age: 75. Read More

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November 2018
4 Reads

Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias.

Front Neurol 2018 29;9:894. Epub 2018 Oct 29.

Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

Delayed auditory feedback (DAF) is a classical paradigm for probing sensori-motor interactions in speech output and has been studied in various disorders associated with speech dysfluency and aphasia. However, little information is available concerning the effects of DAF on degenerating language networks in primary progressive aphasia: the paradigmatic "language-led dementias." Here we studied two forms of speech output (reading aloud and propositional speech) under natural listening conditions (no feedback delay) and under DAF at 200 ms, in a cohort of 19 patients representing all major primary progressive aphasia syndromes vs. Read More

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October 2018
4 Reads

Left Transsylvian-Transinsular Approach for Radiation-Induced Cavernous Malformation: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 8. Epub 2018 Nov 8.

Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona.

De novo cavernous malformation (CM) formation after radiation therapy for brain tumors is well known, but CM formation adjacent to a radiosurgically treated arteriovenous malformation (AVM) is rare.1 This video demonstrates the microsurgical resection of a de novo CM adjacent to a previously treated high-grade AVM and clipping of a middle cerebral artery (MCA) aneurysm. A 70-yr-old male with history of radiosurgery for AVM presented with aphasia and confusion. Read More

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November 2018
4 Reads

Factors associated with long-term mortality for stroke unit patients in Latvia.

Brain Behav 2018 Nov 12:e01152. Epub 2018 Nov 12.

Riga Stradiņš University, Riga, Latvia.

Aim: The aim of this study was to evaluate how pre-stroke risk factors, neurological symptoms, and the level of disability shortly after stroke are associated with poststroke mortality during a 7-year period after stroke, for persons treated in a stroke unit.

Methods: The data of 231 patients were included in the study. Patients who were treated in the stroke unit at the Riga East University Hospital between February 1, 2009, and July 20, 2009, were included in this study. Read More

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November 2018
7 Reads

Impairments of auditory-verbal short-term memory: Do selective deficits of the input phonological buffer exist?

Cortex 2018 Oct 11. Epub 2018 Oct 11.

CIMEC, University of Trento, Italy; Psychology Department, University of Milan-Bicocca, Italy.

The existence of the functional syndrome of auditory-verbal short-term storage impairment was used as strong supporting evidence for the presence of a phonological buffer in the first version of the Baddeley-Hitch working memory model. In later versions the syndrome corresponded to the selective impairment of the phonological input buffer. The present paper considers whether the correspondence between the functional syndrome, represented by 20 published cases, and a Baddeley-Hitch model component is still of value to memory theory. Read More

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October 2018
1 Read

[Intraoperative mapping of long association fibers in surgery of gliomas of the speech-dominant frontal lobe].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(5):5-20

Burdenko Neurosurgical Institute, Moscow, Russia.

Surgery of intracerebral tumors involving long association fibers is a challenge. In this study, we analyze the results of intraoperative mapping of the superior longitudinal, arcuate, and frontal aslant tracts in surgery of brain gliomas.

Purpose: The study purpose was to compare the results of intraoperative mapping and the postoperative speech function in patients with gliomas of the premotor area of the speech-dominant frontal lobe, which involved the superior longitudinal, arcuate, and frontal aslant tracts, who were operated on using awake craniotomy. Read More

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January 2018
11 Reads

Mild encephalitis/encephalopathy with a reversible splenial lesion due to malaria: a case report.

Trop Med Health 2018 6;46:37. Epub 2018 Nov 6.

1Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.

Background: Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. Read More

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November 2018
3 Reads