53,467 results match your criteria Aortic Stenosis


Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta.

Physiol Genomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin.

Coarctation of the aorta (CoA) is a common congenital cardiovascular (CV) defect characterized by a stenosis of the descending thoracic aorta. Treatment exists, but many patients develop hypertension (HTN). Identifying the cause of HTN is challenging because of patient variability (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00049.2018DOI Listing

Habitual Physical Activity: Functional Assessment in Patients With Severe Aortic Stenosis Treated With TAVR.

JACC Cardiovasc Interv 2019 Apr;12(8):790-792

Center for Interventional Vascular Therapy, Columbia University Medical Center/NewYork-Presbyterian Hospital, and the Cardiovascular Research Foundation, New York, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcin.2019.03.010DOI Listing

Habitual Physical Activity in Older Adults Undergoing TAVR: Insights From the FRAILTY-AVR Study.

JACC Cardiovasc Interv 2019 Apr;12(8):781-789

Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

Objectives: The authors sought to assess the distribution and prognostic significance of habitual physical activity (HPA) in older adults undergoing transcatheter aortic valve replacement (TAVR).

Background: Low HPA is associated with mortality and disability in community-dwelling older adults. In the setting of TAVR, it is unclear whether low HPA is a risk factor for downstream morbidity or a byproduct of severe aortic stenosis that improves following its correction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19368798193063
Publisher Site
http://dx.doi.org/10.1016/j.jcin.2019.02.049DOI Listing
April 2019
1 Read

Classical and Paradoxical Low-Flow, Low-Gradient Aortic Stenosis: The Evolving Role of TAVR.

JACC Cardiovasc Interv 2019 Apr;12(8):764-766

Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19368798193055
Publisher Site
http://dx.doi.org/10.1016/j.jcin.2019.02.022DOI Listing
April 2019
1 Read

1-Year Survival After TAVR of Patients With Low-Flow, Low-Gradient and High-Gradient Aortic Valve Stenosis in Matched Study Populations.

JACC Cardiovasc Interv 2019 Apr;12(8):752-763

Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany; Medical Clinic I (Cardiology and Angiology), University Hospital of Giessen, Giessen, Germany; Department of Cardiac Surgery, Kerckhoff Heart Center, Bad Nauheim, Germany.

Objectives: This study sought to examine whether the prognosis of patients with severe aortic stenosis (AS) having high versus low transvalvular mean pressure gradients (MPGs) is intrinsically different after transcatheter aortic valve replacement (TAVR), even after strict matching of baseline parameters.

Background: Patients with low MPG are characterized by higher cardiovascular risk and more comorbidities than other AS patients are.

Methods: In this retrospective, single-center study involving 2,282 patients, 3 groups were derived according to the following criteria: 1) high-gradient AS (HG-AS) (MPG ≥40 mm Hg); 2) low-flow, low-gradient AS (LFLG-AS) (MPG <40 mm Hg, ejection fraction [EF] ≤40%, stroke volume index ≤35 ml/m); 3) paradoxical LFLG-AS (pLFLG-AS) (similar to LFLG-AS but with EF ≥50%). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcin.2019.01.233DOI Listing

Surgical versus balloon valvotomy in neonates and infants: results from the UK National Audit.

Open Heart 2019 14;6(1):e000938. Epub 2019 Feb 14.

Departments of Cardiac Surgery and Cardiology, Bristol Royal Hospital for Children, Bristol, UK.

Objective: There are conflicting data on choosing balloon aortic valvoplasty (BAV) or surgical aortic valvotomy (SAV) in neonates and infants requiring intervention for aortic valve stenosis. We aim to report the outcome of both techniques based on results from the UK national registry.

Methods: This is a retrospective study, including all patients under 1 year undergoing BAV/SAV between 2000 and 2012. Read More

View Article

Download full-text PDF

Source
http://openheart.bmj.com/lookup/doi/10.1136/openhrt-2018-000
Publisher Site
http://dx.doi.org/10.1136/openhrt-2018-000938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443132PMC
February 2019
2 Reads

Unexpected massive pleural effusion leading to discovery of left subclavian artery rupture during transcatheter aortic valve implantation.

J Cardiol Cases 2019 Apr 13;19(4):136-139. Epub 2019 Feb 13.

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

An 89-year-old woman underwent transcatheter aortic valve implantation (TAVI) for severe aortic valve stenosis, based on a logistic European System for Cardiac Operative Risk Evaluation of 59.6% and Society of Thoracic Surgeons risk score of 17.1%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jccase.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451059PMC
April 2019
1 Read

Transcatheter aortic valve replacement in a patient with anomalous origin of the left coronary artery.

J Cardiol Cases 2019 Apr 10;19(4):133-135. Epub 2019 Feb 10.

Division of Cardiology, Department of Internal Medicine, Inje University College of Medicine, Seoul Paik Hospital, Seoul, South Korea.

Transcatheter aortic valve replacement (TAVR) is widely performed in patients with severe aortic stenosis (AS), having a high surgical risk. However, reports of TAVR performed in patients with anomalous coronary arteries are rare. In existing literature, several complications including coronary obstruction are reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jccase.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451060PMC
April 2019
1 Read

Angina and left ventricular dysfunction: can we 'reduce' it?

Eur Heart J Suppl 2019 Apr 10;21(Suppl C):C28-C31. Epub 2019 Apr 10.

Department of Medical Sciences Ferrara University, Ferrara, Italy.

Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a bioprosthesis for severe aortic stenosis with subsequent transcatheter valve-in-valve implantation for bioprosthesis degeneration and single coronary artery bypass graft with left internal mammary artery on left anterior descending (LAD). After transcatheter aortic valve implantation, she started to complain angina [Canadian Cardiovascular Society (CCS) Class III], effectively treated with bisoprolol uptitration and ivabradine 5 b. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/suz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456877PMC
April 2019
3 Reads

[A strategic roadmap of the Italian Society of Interventional Cardiology (SICI-GISE) to ensure patient's access to appropriate treatment].

G Ital Cardiol (Rome) 2019 Apr;20(4):4-19

A.O. Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna.

In comparison with the international scenario, in Italy the penetration of several important scientific and technological innovations in the field of cardiovascular intervention appears to be inadequate both in terms of number of patients treated with respect to the actual need, and inhomogeneity between the different geographical areas of the country. One of the main institutional objectives of the Italian Society of Interventional Cardiology (SICI-GISE) is to develop a roadmap to guarantee homogeneous access throughout the whole national territory to treatments that are recommended by the major international guidelines. The present document focuses on four main areas of cardiovascular intervention: (i) transcatheter treatment of aortic valve stenosis, (ii) percutaneous mitral valve repair, (iii) prevention of cardioembolic stroke through percutaneous left atrial appendage occlusion in patients with non-valvular atrial fibrillation, (iv) optimization of coronary revascularization with the aid of the functional study of coronary lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1714/3146.31274DOI Listing
April 2019
2 Reads

Nutritional risk index is a better predictor of early mortality than conventional nutritional markers after trans-catheter aortic valve replacement: A prospective cohort study.

Cardiol J 2019 Apr 17. Epub 2019 Apr 17.

University Hospital Frankfurt am Main, Cardiology Department, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Background: Nutritional risk index (NRI) has been shown to better predict survival than body mass index (BMI) or albumin after several cardiovascular interventions. Under assessment herein is whether NRI can have higher predictive value than conventional parameters for short-term survival after transcatheter aortic valve replacement (TAVR).

Methods: A prospective cohort study was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5603/CJ.a2019.0038DOI Listing
April 2019
1 Read

Mid-term Clinical Outcomes in a Cohort of Asymptomatic or Mildly Symptomatic Korean Patients with Bicuspid Aortic Valve in a Tertiary Referral Hospital.

J Cardiovasc Imaging 2019 Apr;27(2):105-118

Valvular Heart Disease Center, Asan Medical Center Heart Institute, University of Ulsan College of Medicine, Seoul, Korea.

Background: Although bicuspid aortic valve (BAV) is one of the most common congenital heart diseases, clinical outcome data regarding BAV are still limited. We evaluated clinical characteristics and mid-term clinical outcomes of asymptomatic Korean patients with bicuspid aortic valve.

Methods: We initiated a prospective registry in 2014 at a tertiary referral hospital. Read More

View Article

Download full-text PDF

Source
https://synapse.koreamed.org/DOIx.php?id=10.4250/jcvi.2019.2
Publisher Site
http://dx.doi.org/10.4250/jcvi.2019.27.e19DOI Listing
April 2019
2 Reads

Hemodynamic comparison of CoreValve and SAPIEN-XT TAVI valves in Japanese patients.

Heart Vessels 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiology, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura, 247-8533, Japan.

Transcatheter aortic valve implantation (TAVI) is a viable treatment option for high-risk patients with severe aortic stenosis. In Japan, TAVI can be performed using first-generation self-expandable Medtronic CoreValve or balloon-expandable Edwards SAPIEN-XT from 2012. Since the durability and hemodynamic outcomes after transcatheter heart valve (THV) implantation in Japanese patients have not been clearly elucidated, we assessed serial changes in post-TAVI THV performances over a-3-year period by transthoracic echocardiography (TTE). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00380-019-01414-0
Publisher Site
http://dx.doi.org/10.1007/s00380-019-01414-0DOI Listing
April 2019
2 Reads

Clinical safety and efficacy of tolvaptan for acute phase therapy in patients with low-flow and normal-flow severe aortic stenosis.

Heart Vessels 2019 Apr 16. Epub 2019 Apr 16.

Division of Cardiology, Department of Internal Medicine, Teikyo University, 2-11-1 Kaga, Tokyo, 173-8606, Japan.

Conventional diuretic therapy for low-flow (LF) severe aortic stenosis (SAS) often has an inadequate effect or causes hemodynamic instability. Tolvaptan is used for acute heart failure in addition to conventional diuretics, and it does not cause intravascular dehydration. This study aimed to retrospectively investigate the safety and efficacy of tolvaptan in the acute phase in 56 consecutive patients with SAS and compared LF-SAS with normal-flow (NF) SAS. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00380-019-01411-3
Publisher Site
http://dx.doi.org/10.1007/s00380-019-01411-3DOI Listing
April 2019
5 Reads

[Post Radiotherapy Lesions of the Heart Valves. Principles of Diagnosis and Results of Treatment].

Kardiologiia 2019 Apr 12;59(3):36-42. Epub 2019 Apr 12.

A. N. Bakoulev Scientific Center for Cardiovascular Surgery.

Background: The use of radiation therapy for the treatment of tumors of the chest сan lead to the development of cardiac pathology, including that of the valves and coronary arteries.

Study Aim: to analyze the specifics of post-radiation lesions of the valvular apparatus and coronary arteries, and to assess the immediate results and risks of surgical correction of detected defects. Materials and  methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18087/cardio.2019.3.10239DOI Listing
April 2019
1 Read

Long-term outcomes in Japanese nonagenarians undergoing transcatheter aortic valve implantation: a multi-center analysis.

Clin Cardiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Background: Japan is an aging society and the number of nonagenarians with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) is increasing, but their outcomes have not been determined fully.

Methods: We prospectively enrolled 767 consecutive patients who underwent TAVI in three Japanese institutions. Clinical characteristics and outcomes of nonagenarians (n=94) were evaluated and compared with those of patients aged <90 years (n=673). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/clc.23183DOI Listing
April 2019
1 Read

One Hundred and Counting: Dr. Dwight C. McGoon's Enduring Legacy.

Ann Thorac Surg 2019 Apr 12. Epub 2019 Apr 12.

Department of Cardiovascular Surgery, Mayo Clinic, 200 First St SW, Rochester, Minnesota 55905.

Dr. Dwight C. McGoon, a prolific surgeon at the Mayo Clinic, achieved an amazing feat during the early days of cardiac surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2019.02.073DOI Listing
April 2019
2 Reads

Genetic variants in cardiac calcification in Northern Sweden.

Medicine (Baltimore) 2019 Apr;98(15):e15065

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Extensive coronary calcification without significant stenosis, described as calcific coronary artery disease (CCAD) may cause abnormal myocardial perfusion and hence generalized ischemia. There is a discrepancy in the expression pattern of CCAD compared to the well-known atherosclerotic disease which raises questions about the exact pathophysiology of coronary calcification and whether there is a genetic etiology for it.In this pilot study we studied 3 candidate genes, ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1), ATP Binding Cassette Subfamily C Member 6 (ABCC6), and 5'-Nucleotidase Ecto (NT5E) involved in pyrophosphate (PPi) and inorganic phosphate (Pi) metabolism, which may predispose to coronary arterial or valvular calcification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015065DOI Listing
April 2019
3 Reads

Clinical features and outcomes of revascularization in very old patients with left main coronary artery disease.

Coron Artery Dis 2019 Apr 10. Epub 2019 Apr 10.

Faculty of Medicine, Technion, Israel Institute of Medicine, Haifa, Israel.

Background: Coronary artery disease (CAD) is often more extensive in older adults and may involve multivessel and left main coronary artery (LMCA) disease. Elderly patients are commonly excluded from clinical trials, and limited real-world data exist on the management of LMCA disease in the very old. We aimed to investigate clinical features and outcomes of very old patients undergoing revascularization due to LMCA disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCA.0000000000000744DOI Listing
April 2019
1 Read

Rationale and design of the randomized, controlled Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis (EVOLVED) trial.

Am Heart J 2019 Mar 15;212:91-100. Epub 2019 Mar 15.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom. Electronic address:

Background: The optimal timing of aortic valve replacement in asymptomatic patients with aortic stenosis is uncertain. Replacement fibrosis, as assessed by midwall (nonischemic) late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging, is an irreversible marker of left ventricular decompensation in aortic stenosis. Once established, it progresses rapidly and is associated with poor long-term prognosis in a dose-dependent manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ahj.2019.02.018DOI Listing
March 2019
1 Read

Postoperative atrial fibrillation after aortic valve replacement is a risk factor for long-term atrial fibrillation.

Interact Cardiovasc Thorac Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Cardiology, Odense University Hospital, Odense, Denmark.

Objectives: Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. However, knowledge on the rate of long-term atrial fibrillation (LTAF) after POAF remains unclear. We investigated predictors of POAF in patients with aortic stenosis undergoing surgical aortic valve replacement, and assessed the rate of LTAF during follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/icvts/ivz094DOI Listing
April 2019
1 Read

Update on the clinical impact of mild aortic regurgitation after transcatheter aortic valve implantation: Insights from the Japanese multicenter OCEAN-TAVI registry.

Catheter Cardiovasc Interv 2019 Apr 11. Epub 2019 Apr 11.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Objectives: This study aimed to compare the clinical impact of mild postprocedural aortic regurgitation (post-AR) to that of none-trivial post-AR after transcatheter aortic valve implantation (TAVI) and to identify the vulnerability factors to mild post-AR.

Background: Moderate-severe post-AR, associated with increased mortality, is an important issue. However, the clinical impact of mild post-AR remains controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccd.28279DOI Listing
April 2019
1 Read

Reduction in thrombogenic activity and thrombocytopenia after transcatheter aortic valve implantation - The ATTRACTIVE-TTAS study.

Int J Cardiol Heart Vasc 2019 Jun 28;23:100346. Epub 2019 Mar 28.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Introduction: Bleeding complications after transcatheter aortic valve implantation (TAVI) is a major problem in clinical practice. However, there is few information on thrombogenicity after TAVI. The aim of this study was to establish a monitoring of total thrombogenicity in perioperative TAVI using the Total Thrombus-formation Analysis System (T-TAS), a microchip-based flow chamber system for analysis of thrombus formation under flow condition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcha.2019.100346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441766PMC
June 2019
1 Read

Predicted coronary occlusion and Impella salvage during valve-in-valve transcatheter aortic valve replacement.

Cardiovasc Revasc Med 2019 Mar 29. Epub 2019 Mar 29.

Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, United States of America.

We describe an interesting case of a 71 years old fragile female, with progressive shortness of breath on exertion and ankle swelling, cardiac failure NYHA class III. She also had chest irradiation due to Hodgkin's disease many years before, previous surgical aortic valve replacement using bioprosthetic stent-less Freestyle #25 mm valve (Medtronic, Inc) in 2000 for severe aortic stenosis, history of cardiac arrest in 2012 and angioplasty to ostial RCA, PCI to ostial RCA in 2014, CABG (RA graft to RCA) in 2014 (RCA intra-stent restenosis with refractory ischemia), anemia requiring regular transfusions, bronchiectasis and chronic kidney disease. Because of the great comorbidities, STS 4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carrev.2019.03.019DOI Listing
March 2019
1 Read

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload.

J Am Coll Cardiol 2019 Apr;73(14):1795-1806

School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre, London, United Kingdom. Electronic address:

Background: The mitochondrial unfolded protein response (UPR) is activated when misfolded proteins accumulate within mitochondria and leads to increased expression of mitochondrial chaperones and proteases to maintain protein quality and mitochondrial function. Cardiac mitochondria are essential for contractile function and regulation of cell viability, while mitochondrial dysfunction characterizes heart failure. The role of the UPR in the heart is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2018.12.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456800PMC
April 2019
1 Read

Aortic annulus measurement with computed tomography angiography reduces aortic regurgitation after transfemoral aortic valve replacement compared to 3-D echocardiography: a single-centre experience.

Clin Res Cardiol 2019 Apr 10. Epub 2019 Apr 10.

Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, Department of Internal Medicine I, University Hospital Jena, Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany.

Background: Accurate assessment of the aortic annulus is crucial for successful transcatheter aortic valve replacement (TAVR), in particular to prevent paravalvular regurgitation (PVR). We compared aortic annular sizing using multidetector computed tomography (MDCT) and three-dimensional transoesophageal echocardiography (3-D TEE) to determine the predictive value of MDCT.

Methods And Results: All patients admitted for transfemoral TAVR [n = 227; 48. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00392-019-01462-6
Publisher Site
http://dx.doi.org/10.1007/s00392-019-01462-6DOI Listing
April 2019
3 Reads

Comparison of grading of aortic stenosis between transthoracic and transesophageal echocardiography in adult patients undergoing elective aortic valve replacement surgeries: A prospective observational study.

Ann Card Anaesth 2019 Apr-Jun;22(2):194-198

Department of Cardiac Anesthesia, AIIMS, New Delhi, India.

Introduction: Intraoperative trans-esophageal echocardiography (TEE) has been found to underestimate severity of aortic stenosis (AS) compared to trans-thoracic echo (TTE). We conducted a prospective study comparing pre induction TTE and intra operative TEE grading of AS in patients posted for aortic valve replacement surgeries.

Methods: Sixty patients with isolated AS who were undergoing aortic valve replacement were enrolled in our study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aca.ACA_4_18DOI Listing
April 2019
1 Read

Long-term outcomes with balloon-expandable and self-expandable prostheses in patients undergoing transfemoral transcatheter aortic valve implantation for severe aortic stenosis.

Int J Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.

Background: Data on long-term outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) is scarce.

Methods: We investigated long term outcomes of consecutive patients undergoing TAVI with balloon- and self-expandable bioprostheses (Edwards SAPIEN (ESV), Edwards Lifesciences Inc., Irvine, CA, USA; Medtronic Corevalve system (MCS), Medtronic Inc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.03.050DOI Listing
March 2019
1 Read

Mixed aortic valve disease treated with transcatheter aortic valve replacement in a high risk patient presenting with acute decompensated heart failure.

Catheter Cardiovasc Interv 2019 Apr 10. Epub 2019 Apr 10.

Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California.

Mixed aortic valve disease refers to the combination of aortic regurgitation (AR) and aortic stenosis (AS). Commonly etiologies include a bicuspid aortic valve, rheumatic heart disease, and endocarditis superimposed upon a stenotic aortic valve. Treatment depends upon the severity of disease, the presence of symptoms and the size and function of the left ventricle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccd.28221DOI Listing
April 2019
1 Read

Impact of moderate to severe mitral stenosis in patients undergoing transcatheter aortic valve replacement.

Int J Cardiol 2019 Mar 28. Epub 2019 Mar 28.

Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:

Objective: In patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), the impact of concomitant mitral stenosis (MS) remains unknown. The aim of this study was to determine the incidence and impact of moderate to severe MS in patients undergoing TAVR.

Methods: The study included 2113 consecutive patients (mean age: 80 ± 9 years, mean STS: 6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.03.053DOI Listing
March 2019
1 Read

Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.

J Bone Miner Metab 2019 Apr 8. Epub 2019 Apr 8.

Department of Pharmacology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Warfarin, a vitamin K antagonist, is the most common anticoagulant used to prevent thromboembolisms associated with atrial fibrillation or following valvular surgery. Although several studies have revealed that long-term warfarin use accelerates aortic valve calcification and the development of aortic stenosis (AS), the detailed mechanism for this phenomenon remains unclear. Therefore, our aim was twofold: to establish the conditions for warfarin-induced calcification of human aortic valve interstitial cells (HAVICs) using high-inorganic phosphate (Pi) conditions and to investigate the underlying mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00774-019-01001-3DOI Listing
April 2019
1 Read

Biallelic variants in SMAD6 are associated with a complex cardiovascular phenotype.

Hum Genet 2019 Apr 8. Epub 2019 Apr 8.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Rare heterozygous variants in SMAD6 have been identified as a significant genetic contributor to bicuspid aortic valve-associated thoracic aortic aneurysm on one hand and non-syndromic midline craniosynostosis on the other. In this study, we report two individuals with biallelic missense variants in SMAD6 and a complex cardiac phenotype. Trio exome sequencing in Proband 1, a male who had aortic isthmus stenosis, revealed the homozygous SMAD6 variant p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-019-02011-xDOI Listing
April 2019
1 Read

Predicting asymptomatic coronary artery stenosis by aortic arch plaque in acute ischemic cerebrovascular disease: beyond the cervicocephalic atherosclerosis?

Chin Med J (Engl) 2019 Apr;132(8):905-913

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: Asymptomatic coronary artery stenosis (ACAS) ≥50% is common in patients with acute ischemic cerebrovascular disease (AICVD), which portends a poor cardiovascular and cerebrovascular prognosis. Identifying ACAS ≥50% early may optimize the clinical management and improve the outcomes of these high-risk AICVD patients. This study aimed to investigate whether aortic arch plaque (AAP), an early atherosclerotic manifestation of brain blood-supplying arteries, could be a predictor for ACAS ≥50% in AICVD. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00029330-201904200-0000
Publisher Site
http://dx.doi.org/10.1097/CM9.0000000000000174DOI Listing
April 2019
1 Read

Clinical outcomes in high-risk patients with a severe aortic stenosis: a seven-year follow-up analysis.

Swiss Med Wkly 2019 Feb 24;149:w20013. Epub 2019 Feb 24.

Department of Cardiology, Swiss Cardiovascular Centre Bern, University Hospital, Bern, Switzerland.

Introduction: The aim of this study was to assess the clinical outcomes of high-risk patients with severe aortic stenosis (AS) allocated to medical treatment (MT), transcatheter aortic valve replacement (TAVR), and surgical aortic valve replacement (SAVR) through extended follow-up.

Methods And Results: Consecutive patients with severe symptomatic AS included in a prospective single centre registry underwent sweep follow-up between March and August 2016. Clinical outcomes were assessed using a competing risk model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2019.20013DOI Listing
February 2019

Current Key Issues in Transcatheter Aortic Valve Replacement Undergoing a Paradigm Shift.

Circ J 2019 Apr 5. Epub 2019 Apr 5.

Cardiovascular Center, Department of Internal Medicine, Seoul National University Hospital.

As a new technology in the management of valvular heart disease, transcatheter aortic valve replacement (TAVR) has drawn much attention since its emergence. To date, numerous studies have investigated the safety and efficacy of TAVR in patients of various risk profiles with severe aortic stenosis (AS) and demonstrated comparable or superior outcomes of TAVR when compared with surgical aortic valve replacement (SAVR). The favorable outcomes of TAVR in inoperable patients, as well as in high- and intermediate-risk patients, are endorsed in current guidelines, and trials of low-risk patients have shown non-inferior or even superior results of TAVR than for SAVR, suggesting that the clinical indications of TAVR can be expanded to low-risk patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1253/circj.CJ-19-0096DOI Listing
April 2019
2 Reads

Current status and future perspective of structural heart disease intervention.

J Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Germany. Electronic address:

Valvular heart diseases are one of the most frequent causes for heart failure. Degenerative diseases of the aortic and mitral valve as well as a dysfunctional tricuspid valve disease result in a worse clinical outcome if severe. Minimal-invasive, surgical and/or catheter-based structural heart disease (SHD) interventions have recently seen a dramatic increase. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09145087193008
Publisher Site
http://dx.doi.org/10.1016/j.jjcc.2019.02.022DOI Listing
April 2019
4 Reads

Esophageal stenosis secondary to aortic dissection.

Med Intensiva 2019 Apr 4. Epub 2019 Apr 4.

Unidad de Cuidados Intensivos Cardiológica, Hospital Universitario 12 de Octubre, Madrid, España.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.medin.2019.02.003DOI Listing
April 2019
1 Read

Phenotypes of aortic valve disease according to detailed anatomical classification of patients who underwent aortic valve replacement surgery.

Cardiovasc Pathol 2019 Jan 19;41:1-7. Epub 2019 Jan 19.

National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China; Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Background: The anatomy of the aortic valves plays an important role in the progression of aortic valve disease (AVD) and determination of the appropriate treatment strategy. We described and compared AVD phenotypes according to detailed anatomical classifications and assessed the accuracy of imaging diagnostics using surgical diagnosis as the gold standard.

Methods And Results: The study enrolled 602 patients (mean age 55. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carpath.2019.01.004DOI Listing
January 2019
4 Reads
2.336 Impact Factor

CT-derived left ventricular global strain: a head-to-head comparison with speckle tracking echocardiography.

Int J Cardiovasc Imaging 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, Friedrich-Alexander-Universität, Ulmenweg 18, 91054, Erlangen-Nürnberg, Germany.

We assessed CT-derived left ventricular strain in a cohort of patients referred for transcatheter aortic valve implantation (TAVI) and validated it against 2 dimensional speckle tracking echocardiography as the gold standard. 65 consecutive patients with symptomatic aortic valve stenosis referred for CT imaging prior to TAVI were included in this analysis. For all patients, retrospectively ECG-gated multi-phase functional CT data sets acquired with identical reconstruction parameters were available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10554-019-01596-8DOI Listing
April 2019
2 Reads

Valve-sparing root replacement and composite valve graft replacement in patients with aortic regurgitation: From the Japan Cardiovascular Surgery Database.

J Thorac Cardiovasc Surg 2019 Feb 15. Epub 2019 Feb 15.

Japan Cardiovascular Surgery Database, Tokyo, Japan.

Objectives: The advantage of valve-sparing root replacement (VSRR) over aortic root replacement with a composite valve graft (CVG) remains unclear. We compared these 2 procedures with regard to early outcomes with propensity score matching using the Japan Cardiovascular Surgery Database.

Methods: Of 5303 patients from the Japan Cardiovascular Surgery Database who had undergone aortic root replacement in 2008 to 2017, emergent/urgent or redo cases and those with infective endocarditis or aortic stenosis were excluded (included n = 3841). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtcvs.2019.01.122DOI Listing
February 2019
2 Reads

NETosis is associated with the severity of aortic stenosis: Links with inflammation.

Int J Cardiol 2019 Mar 26. Epub 2019 Mar 26.

John Paul II Hospital, Kraków, Poland; Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland. Electronic address:

Background: An involvement of neutrophil extracellular traps (NETs) in the aortic stenosis (AS) pathogenesis is unknown.

Methods: We enrolled 50 patients, median age 66.5 years with isolated severe AS, after aortic valve replacement and 20 healthy sex/age-matched controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.03.047DOI Listing
March 2019
2 Reads

Effectiveness of treatment of innominate artery stenosis with retrograde supra-aortic stent using a flow reversal stent system.

Proc (Bayl Univ Med Cent) 2018 Oct 21;31(4):493-495. Epub 2018 Sep 21.

Division of Vascular Surgery, Baylor University Medical CenterDallasTexas.

We present the case of a 71-year-old man with critical stenosis of the innominate artery after previously undergoing bilateral carotid artery endarterectomies. We used an open retrograde approach of the right carotid artery to stent the innominate artery lesion employing the new ENROUTE Transcarotid Stent System with flow reversal. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
Publisher Site
http://dx.doi.org/10.1080/08998280.2018.1483154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414015PMC
October 2018
4 Reads

Validation of a low-dose contrast 64-slice cardiac computed tomography angiography protocol for aortic valve annulus sizing.

Proc (Bayl Univ Med Cent) 2018 Oct 26;31(4):414-418. Epub 2018 Sep 26.

The Heart Hospital Baylor PlanoPlanoTexas.

Cardiac computed tomography angiography (CCTA) is the gold standard for accurately sizing the aortic valve annulus prior to aortic valve replacement. A reduction of contrast volume administered for CCTA, without sacrificing image quality, is desirable. Signal-to-noise ratio represents final CCTA image quality. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
Publisher Site
http://dx.doi.org/10.1080/08998280.2018.1482515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414014PMC
October 2018
2 Reads

Moderate aortic stenosis and left ventricular dysfunction: an ominous association.

Eur Heart J Suppl 2019 Mar 29;21(Suppl B):B15-B16. Epub 2019 Mar 29.

Cardio-Neuro-Vascular Department, Azienda USL Toscana Sud-Est, Arezzo, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/suz012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439899PMC
March 2019
2 Reads

Characteristics and Outcomes of Patients With Severe Aortic Stenosis Discussed by the Multidisciplinary "Heart Team" According to Treatment Allocation.

Heart Lung Circ 2019 Mar 14. Epub 2019 Mar 14.

Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.

Background: Transcatheter aortic valve implantation (TAVI) is an alternative and effective contemporary intervention to surgical aortic valve replacement (SAVR) for patients with severe aortic valve disease at increased surgical risk. Guidelines recommend a multidisciplinary "Heart Team" (MHT) review of patients considered for a TAVI procedure, but this has been little studied. We reviewed the characteristics, treatments and outcomes of such patients reviewed by the MHT at our centre. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14439506193027
Publisher Site
http://dx.doi.org/10.1016/j.hlc.2019.02.192DOI Listing
March 2019
4 Reads

1-Year Outcomes of the CENTERA-EU Trial Assessing a Novel Self-Expanding Transcatheter Heart Valve.

JACC Cardiovasc Interv 2019 Apr;12(7):673-680

Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany.

Objectives: The purpose of this study is to report the 1-year results of the CENTERA-EU trial.

Background: The CENTERA transcatheter heart valve (THV) (Edwards Lifesciences, Irvine, California) is a low-profile (14-F eSheath compatible), self-expanding nitinol valve, with a motorized delivery system allowing for repositionability. The 30-day results of the CENTERA-EU trial demonstrated the short-term safety and effectiveness of the valve. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19368798193038
Publisher Site
http://dx.doi.org/10.1016/j.jcin.2019.01.231DOI Listing
April 2019
3 Reads