65,653 results match your criteria Aortic Stenosis


The tyrosine kinase inhibitor nilotinib targets discoidin domain receptor 2 in calcific aortic valve stenosis.

Br J Pharmacol 2022 Jun 25. Epub 2022 Jun 25.

Department of Medicine, Karolinska Institutet.

Background And Purpose: Tyrosine kinase inhibitors (TKI) used to treat chronic myeloid leukemia (CML) have been associated with cardiovascular side effects, including reports on calcific aortic valve stenosis. The aim of this study was to establish the effects of first and second generation TKIs in aortic valve stenosis, and to determine the associated molecular mechanisms EXPERIMENTAL APPROACH: Treatment of APOE*3Leiden.CETP transgenic mice with nilotinib, imatinib or vehicle. Read More

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Riociguat attenuates left ventricular proteome and microRNA profile changes after experimental aortic stenosis in mice.

Br J Pharmacol 2022 Jun 25. Epub 2022 Jun 25.

German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.

Background And Purpose: Development and progression of heart failure (HF) involve endothelial and myocardial dysfunction as well as a dysregulation of the nitric oxide - soluble guanylyl cyclase - cyclic guanosine monophosphate (NO-sGC-cGMP) signalling pathway. Recently, we reported that the sGC stimulator riociguat (RIO) has beneficial effects on cardiac remodelling and progression of HF in response to chronic pressure overload. Here, we examined if these favourable RIO effects are also reflected in alterations of the myocardial proteome and microRNA profiles. Read More

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The UK TAVI trial: an independent, pragmatic study extending the evidence for the treatment of symptomatic severe aortic stenosis.

Eur Heart J 2022 Jun 25. Epub 2022 Jun 25.

Cardiology Department, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.

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Controlled Comparison of Simulated Hemodynamics Across Tricuspid and Bicuspid Aortic Valves.

Ann Biomed Eng 2022 Jun 24. Epub 2022 Jun 24.

Institute for Computational & Mathematical Engineering, Stanford University, Stanford, CA, USA.

Bicuspid aortic valve is the most common congenital heart defect, affecting 1-2% of the global population. Patients with bicuspid valves frequently develop dilation and aneurysms of the ascending aorta. Both hemodynamic and genetic factors are believed to contribute to dilation, yet the precise mechanism underlying this progression remains under debate. Read More

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Single-stage repair for ascending aortic aneurysm, artery stenosis and occlusion of neck vessels caused by Takayasu arteritis.

Interact Cardiovasc Thorac Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Cardiovascular Surgery, Nagoya City University Graduate School of Medical Sciences.

Takayasu arteritis (TA) results in a variety of vascular symptoms, and there are some cases in which progressive vascular lesions require surgical intervention. We present a case with ascending aortic aneurysm, right common carotid artery stenosis, left common carotid artery occlusion, and left subclavian artery stenosis caused by TA that was successfully treated with total arch replacement and ascending aorta to right internal carotid artery bypass. Read More

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Durability of transcatheter aortic valve implantation in bicuspid aortic valve stenosis: the last missing piece?

EuroIntervention 2022 Jun;18(3):185-187

Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, Institut Cœur Poumon, Cardiology, CHU Lille, Lille, France.

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Real-life outcomes and readmissions after a TAVI procedure in a Glasgow population.

Br J Cardiol 2021 1;28(3):37. Epub 2021 Sep 1.

Consultant Cardiologist Department of Cardiology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, G51 4TF.

Transcatheter aortic valve implantation (TAVI) is a routine procedure for patients with symptomatic severe aortic stenosis who are deemed inoperable or high-risk surgical candidates. The aim of this study was to examine real-world data on death and readmission rates in patients following the procedure. Electronic health records for patients who underwent TAVI between April 2015 and November 2018 were reviewed. Read More

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September 2021

Minimising permanent pacemaker implantation (PPI) after TAVI.

Br J Cardiol 2021 22;28(2):20. Epub 2021 Apr 22.

Principal Healthcare Consultant Wilmington Healthcare, 5th Floor, 10 Whitechapel High Street, London, E1 8QS.

Increased demand for transcatheter aortic valve implantation (TAVI) procedures for patients with severe aortic stenosis has not been matched with a proportional increase in available resources in recent years. This article highlights the importance of developing integrated care pathways for TAVI, which incorporate standardised protocols for permanent pacemaker implantation (PPI) to ensure best practice, increase service efficiency and reduce rates of PPI post-TAVI. Read More

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TAVR for severe aortic stenosis and papillary fibroelastoma in a high-risk setting.

Br J Cardiol 2021 22;28(2):23. Epub 2021 Apr 22.

Cardiac Surgeon, and Division Head, Division of Cardiac Surgery St. Michael's Hospital and Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, M5B 1W8, Canada.

Papillary fibroelastomas (PFE) are rare benign cardiac tumours mainly originating on aortic and mitral valvular surfaces. Management is individualised, but most recommend surgical excision due to thromboembolic risk. We report a 75-year-old man with symptomatic severe aortic stenosis compounded by PFE. Read More

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Left Atrial Appendage Amputation for Atrial Fibrillation during Aortic Valve Replacement.

J Clin Med 2022 Jun 14;11(12). Epub 2022 Jun 14.

Department of Cardiac Surgery, Klinikum Nürnberg, Paracelsus Medical University Nuremberg, 90471 Nuremberg, Germany.

Background: Occluding the left atrial appendage (LAA) during cardiac surgery reduces the risk of ischemic stroke; nonetheless, it is currently only softly recommended with "may be considered" by the current guidelines. We aimed to assess thromboembolic risk after LAA amputation in patients with atrial fibrillation (AF) and aortic stenosis undergoing biological aortic valve replacement (AVR) as primary cardiac surgery.

Methods: Two cohorts were generated retrospectively: patients with AF undergoing AVR alone or combined with revascularization either with LAA amputation or without. Read More

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Implication of Lipids in Calcified Aortic Valve Pathogenesis: Why Did Statins Fail?

J Clin Med 2022 Jun 10;11(12). Epub 2022 Jun 10.

Department of Medicine, Division of Nephrology, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Calcific Aortic Valve Disease (CAVD) is a fibrocalcific disease. Lipoproteins and oxidized phospholipids play a substantial role in CAVD; the level of Lp(a) has been shown to accelerate the progression of valve calcification. Indeed, oxidized phospholipids carried by Lp(a) into the aortic valve stimulate endothelial dysfunction and promote inflammation. Read More

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Investigation of Risk Factors for Postoperative Delirium after Transcatheter Aortic Valve Implantation: A Retrospective Study.

J Clin Med 2022 Jun 9;11(12). Epub 2022 Jun 9.

Department of Anesthesiology and Perioperative Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryomachi, Aoba, Sendai 980-8575, Miyagi, Japan.

Transcatheter aortic valve implantation (TAVI) is an effective treatment for severe aortic stenosis (AS); however, postoperative delirium (POD) can worsen patient outcomes. This study aimed to examine the risk factors for POD after TAVI, including possible intervening factors. We included 87 patients (mean age: 83) who underwent TAVI between May 2014 and September 2018. Read More

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A Machine Learning Based Discharge Prediction of Cardiovascular Diseases Patients in Intensive Care Units.

Healthcare (Basel) 2022 May 24;10(6). Epub 2022 May 24.

LPRI, EMSI, Casablanca 23300, Morocco.

This paper targets a major challenge of how to effectively allocate medical resources in intensive care units (ICUs). We trained multiple regression models using the Medical Information Mart for Intensive Care III (MIMIC III) database recorded in the period between 2001 and 2012. The training and validation dataset included pneumonia, sepsis, congestive heart failure, hypotension, chest pain, coronary artery disease, fever, respiratory failure, acute coronary syndrome, shortness of breath, seizure and transient ischemic attack, and aortic stenosis patients' recorded data. Read More

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Ultrasonographic Assessment of Atherosclerotic Renal Artery Stenosis in Elderly Patients with Chronic Kidney Disease: An Italian Cohort Study.

Diagnostics (Basel) 2022 Jun 13;12(6). Epub 2022 Jun 13.

Department of Public Health, University of Naples Federico II, 80100 Naples, Italy.

Although atherosclerotic renal artery stenosis (ARAS) is strictly associated with high cardiovascular risk and mortality, it often may remain unrecognized being clinically silent and frequently masked by co-morbidities especially in elderly patients with coexisting chronic kidney disease (CKD). The present observational study was conducted in elderly CKD-patients with atherosclerosis on other arterial beds. The aims were assessment of (1) ARAS prevalence; (2) best predictor(s) of ARAS, using duplex ultrasound; and (3) cardiovascular and renal outcomes at one-year follow-up. Read More

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The Haemodynamic and Pathophysiological Mechanisms of Calcific Aortic Valve Disease.

Biomedicines 2022 Jun 3;10(6). Epub 2022 Jun 3.

Imperial Vascular Unit, St Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.

The aortic valve (AoV) is the outflow valve for the left heart [... Read More

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Oxidative Stress in Calcific Aortic Valve Stenosis: Protective Role of Natural Antioxidants.

Antioxidants (Basel) 2022 Jun 14;11(6). Epub 2022 Jun 14.

College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun 58554, Jeonnam, Korea.

Calcific aortic valve stenosis (CAVS) is the most prevalent heart valvular disease worldwide and a slowly progressive disorder characterized by thickening of the aortic valve, calcification, and subsequent heart failure. Valvular calcification is an active cell regulation process in which valvular interstitial cells involve phenotypic conversion into osteoblasts/chondrocytes-like cells. The underlying pathophysiology is complicated, and there have been no pharmacological treatments for CAVS to date. Read More

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Surgical aortic valve replacement versus conservative treatment in asymptomatic severe aortic stenosis - Can patients afford to wait?

Cardiovasc Revasc Med 2022 Jun 17. Epub 2022 Jun 17.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA, USA. Electronic address:

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Rationale and design of the Project to look for early discharge in patients undergoing TAVR with ACURATE (POLESTAR Trial).

Cardiovasc Revasc Med 2022 Jun 15. Epub 2022 Jun 15.

Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address:

Background: Transcatheter aortic valve replacement (TAVR) is now an established treatment strategy for elderly patients with symptomatic aortic stenosis (AS) across the entire operative risk spectrum. Streamlined TAVR protocols along with reduced procedure time and expedited ambulation promote early hospital discharge. Selection of patients suitable for safe early discharge after TAVR might improve healthcare efficiency. Read More

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The sweet development and progression of aortic stenosis.

Heart 2022 Jun 23. Epub 2022 Jun 23.

Department of Cardiology, Cornell University Joan and Sanford I Weill Medical College, New York, New York, USA

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Center Valve Preference and Outcomes of Transcatheter Aortic Valve Replacement: Insights From the AMTRAC Registry.

JACC Cardiovasc Interv 2022 Jun;15(12):1266-1274

Department of Cardiology, University Hospital of León, León, Spain.

Background: Data on outcomes of transcatheter aortic valve replacement (TAVR) using balloon-expandable valves (BEVs) or self-expandable valves (SEVs) as well as the impact of center valve preference on these outcomes are limited.

Objectives: The aim of this study was to compare outcomes of TAVR procedures using third-generation BEVs and SEVs stratified by center valve preference.

Methods: In a multicenter registry (n = 17), 13 centers exhibited valve preference (66. Read More

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Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes.

J Cardiovasc Dev Dis 2022 Jun 17;9(6). Epub 2022 Jun 17.

Department of Interventional Cardiology, The John Paul II Hospital, Prądnicka 80, 31-202 Krakow, Poland.

Background: Although degenerative aortic valve stenosis (DAS) is the most prevalent growth-up congestive heart valve disease, still little known about relationships between DAS severity, vascular stiffness (VS), echocardiographic parameters, and serum biomarkers in patients undergoing transcatheter (TAVR) or surgical aortic valve replacement (SAVR). The objective of this study was to identify biomarkers associated with DAS severity, and those that are associated with cardiovascular death (CVD) and episodes of chronic heart failure (CHF) exacerbation.

Methods: A total of 137 patients with initially moderate-to-severe DAS were prospectively evaluated for the relationship between DAS severity, baseline VS, and serum biomarkers (uPAR, GDF-15, Gal-3, IL-6Rα, ET-1, PCSK9, RANTES/CCL5, NT-proBNP, and hs-TnT), and were followed-up for 48 months. Read More

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Structured Allocation of Transcatheter Aortic Valve Replacement Patients during Coronavirus Disease 2019 Pandemic: Impact on Patient Selection and Clinical Results.

J Cardiovasc Dev Dis 2022 Jun 10;9(6). Epub 2022 Jun 10.

Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany.

Due to shortages of medical resources during the Coronavirus Disease 2019 (COVID-19) pandemic, an allocation algorithm for Transcatheter Aortic Valve Replacement (TAVR) was established. We investigated the impact on patient selection and procedural results. In total, 456 TAVR patients before (pre-COVID-19 group) and 456 TAVR patients after (COVID-19 group) the implementation of our allocation algorithm were compared. Read More

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Complete heart block and moderate stenosis aortic post radiation in a young woman with breast cancer.

Ann Med Surg (Lond) 2022 Jun 6;78:103505. Epub 2022 May 6.

Department of Cardiology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.

Introduction: and importance: Although radiotherapy is a well-known cancer treatment and an important part of the therapeutic strategy for achieving long-term remission or disease control, the radiation-induced heart disease rates are high and may occur years later. This article aims to raise clinician awareness of cardiac side effects that can occur years after radiation therapy. In order to develop effective prevention strategies and improve clinical outcomes. Read More

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Synchronous Type 3 EVAR Endoleaks at Multiple Sites Following Transfemoral Transcatheter Aortic Valve Replacement.

JACC Case Rep 2022 Jun 15;4(12):742-750. Epub 2022 Jun 15.

Department of Vascular Surgery, NCH Healthcare System, Naples, Florida, USA.

We describe a complication following transfemoral transcatheter aortic valve replacement in a patient who underwent remote endovascular abdominal aortic aneurysm repair. This report highlights technical complications to be vigilant of when using intravascular catheterization in patients with previous aneurysm repair while also showcasing synchronous type 3 endoleaks at multiple sites. (). Read More

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Single Ventricle and Valve-in-Valve, An Impediment or a New Horizon for TAVR?

JACC Case Rep 2022 Jun 15;4(12):710-714. Epub 2022 Jun 15.

Division of Cardiology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA.

We present a case of a 30-year-old patient with Fontan physiology and prior bioprosthetic valve replacement who developed severe bioprosthetic aortic valve stenosis. We describe the challenges and planning involved to successfully perform a transcatheter aortic valve-in-valve procedure in this especially complex subset of patients. (). Read More

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Transcatheter Aortic Valve Implantation in a Failed Perceval Sutureless Valve, Complicated by Aortic Annular Rupture.

CJC Open 2022 Jun 13;4(6):577-580. Epub 2022 Feb 13.

Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

As the use of surgically implanted sutureless aortic valves has increased over the past decade, we expect to encounter their failure increasingly in coming years. We describe a case of Perceval aortic valve failure with stent infolding and severe stenosis. This condition was treated with valve-in-valve transcatheter aortic valve implantation and complicated by aortic annular rupture at the site of infolding. Read More

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Transient ischemic attack due to multiple spontaneous calcified embolus of the cerebral arteries on a calcified mitral and aortic stenosis.

Radiol Case Rep 2022 Sep 14;17(9):2899-2901. Epub 2022 Jun 14.

Central Imaging Department, Ibn Rochd University Hospital, 1 quartier des hopitaux, Casablanca, Morocco.

We report a case of calcified mitral and aortic stenosis revealed by a reversible ischemic stroke. A 59-year-old male patient, with background of hypertension, kidney failure, diabetes, and dyslipidemia, presented with neither acute onset of right-sided hemiparesis without aphasia nor any loss of consciousness. Head computed tomography (CT) revealed multiple rounded and amorph calcified high-density calcifications within the distal segments of both sylvian and posterior cerebral arteries. Read More

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September 2022

Examination of the most cited studies on transcatheter aortic valve replacement with bibliometric analysis.

Echocardiography 2022 Jun 22. Epub 2022 Jun 22.

Department of Cardiology, Ergani State Hospital, Diyarbakır, Turkey.

Aim: The aim of this study is to analyze the studies on TAVI with the bibliometric method and to perform a scientiometric analysis of the top 100 most cited articles for researchers.

Methods: The Thomson Reuters Web of Science database was searched for all relevant articles using the terms "TAVR" and "TAVI". The results were ordered according to the number of citations. Read More

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Dissociation of early and late face-related processes in autism spectrum disorder and Williams syndrome.

Orphanet J Rare Dis 2022 Jun 22;17(1):244. Epub 2022 Jun 22.

Institut Des Sciences, Cognitives Marc Jeannerod, Centre National de La Recherche Scientifique, 67 boulevard Pinel, 69500, Bron, France.

Background: Williams syndrome (WS) and Autism Spectrum Disorders (ASD) are neurodevelopmental conditions associated with atypical but opposite face-to-face interactions patterns: WS patients overly stare at others, ASD individuals escape eye contact. Whether these behaviors result from dissociable visual processes within the occipito-temporal pathways is unknown. Using high-density electroencephalography, multivariate signal processing algorithms and a protocol designed to identify and extract evoked activities sensitive to facial cues, we investigated how WS (N = 14), ASD (N = 14) and neurotypical subjects (N = 14) decode the information content of a face stimulus. Read More

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Life expectancy after surgical aortic valve replacement for low-gradient aortic stenosis with preserved ejection fraction.

Rev Esp Cardiol (Engl Ed) 2022 Jun 19. Epub 2022 Jun 19.

Departamento de Cirugía Cardiaca, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

Introduction And Objectives: Surgical aortic valve replacement (SAVR) can modify the natural history of severe aortic stenosis (SAS). However, compared with the general population, these patients have a loss of life expectancy. The life expectancy of patients who undergo SAVR due to low-gradient SAS with preserved left ventricular ejection fraction (LVEF) is unknown. Read More

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