61,095 results match your criteria Aortic Stenosis


Impact of comorbidities and antiplatelet regimen on platelet reactivity levels in patients undergoing transcatheter aortic valve implantation.

J Cardiovasc Pharmacol 2021 May 31. Epub 2021 May 31.

Cardiology Department, Hospital Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain. Cardiology Department, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Murcia, Spain. Centro de Investigación en Red de Enfermedades Cardiovasculares (Network Research Center for Cardiovascular Diseases), CIBER-CV, Madrid, Spain. Interventional Cardiology. Instituto de Investigación del Hospital La Paz (IDIPAZ). University Hospital La Paz, Madrid, Spain. Cardiology Department, Hospital Alvaro Cunqueiro, University Hospital of Vigo,Vigo, Spain. Cardiovascular Research Unit, Cardiology Department, Hospital Alvaro Cunqueiro, University Hospital of Vigo, Vigo, Spain; Cardiovascular Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain. Cardiology Department, Hospital Universitario de Bellvitge, Barcelona,Spain. Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada,Spain. Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Santiago de Compostela.

Abstract: The aim of our study is to assess the impact of anemia, chronic kidney disease (CKD) and diabetes mellitus on platelet reactivity (PR) in patients with severe aortic stenosis, both at baseline and after transcatheter aortic valve implantation (TAVI). This study is a pre-specified subanalysis of the REAC-TAVI prospective, multicentre trial that included patients pre-treated with aspirin+clopidogrel before TAVI. PR was measured at baseline and at 5 different time points after TAVI with the VerifyNow assay (Accriva Diagnostics, San Diego, CA), over a 3-month follow-up period. Read More

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Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 Jun 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

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Low Relative Valve Load is Associated With Paradoxical Low-Flow Aortic Stenosis Despite Preserved Left Ventricular Ejection Fraction and Adverse Clinical Outcomes.

Heart Lung Circ 2021 Jun 8. Epub 2021 Jun 8.

Department of Cardiology, National University Heart Centre Singapore, National University Health System, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Background: Paradoxical low-flow (LF) severe aortic stenosis (AS) despite preserved left ventricular (LV) ejection fraction (LVEF) has been shown to be distinct from normal-flow (NF) AS, with a poorer prognosis. Relative valve load (RVL) is a novel echocardiographic haemodynamic index based on the ratio of transaortic mean pressure gradient to the global valvulo-arterial impedance (Zva) in order to estimate the contribution of the valvular afterload to the global LV load. We aimed to determine the usefulness of RVL in LF AS versus NF AS. Read More

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Structural abnormalities after aortic root replacement with stentless xenograft.

J Thorac Cardiovasc Surg 2021 May 12. Epub 2021 May 12.

Department of Cardiothoracic Surgery, The Heart Center, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.

Objective: In complex and high-risk aortic root disease, the porcine Freestyle stentless bioprosthesis (Medtronic Inc, Minneapolis, Minn) is an important surgical treatment option. We aimed to determine prevalence and clinical effect of structural and functional abnormalities after full-root Freestyle implantation.

Methods: Our cross-sectional 2-center study combined with clinical follow-up included 253 patients with full-root Freestyle bioprostheses implanted from 1999 to 2017. Read More

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Non-aneurysmal ascending aorta diameter changes after aortic valve replacement in patients with stenotic bicuspid and tricuspid aortic valve.

Gen Thorac Cardiovasc Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiovascular Surgery, Hiroshima University Hospital, Minami-ku, Hiroshima, 734-8551, Japan.

Objective: The appropriate timing of aortic repair in patients with bicuspid aortic valve-related aortopathy remains controversial. We describe the changes in diameter of the non-aneurysmal ascending aorta after aortic valve replacement for bicuspid or tricuspid aortic valve stenosis.

Methods: This retrospective review included 189 patients who had undergone aortic valve replacement for severe stenotic aortic valve with a non-aneurysmal ascending aorta diameter of 45 mm or less between January 2008 and December 2018. Read More

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Concept of myocardial fatigue in reversible severe left ventricular systolic dysfunction from afterload mismatch: a case series.

Eur Heart J Case Rep 2021 Mar 7;5(3):ytab089. Epub 2021 Mar 7.

Department of Cardiology, University Hospitals of Coventry & Warwickshire NHS Trust, CV2 2DX, UK.

Background : There is already extensive literature on the natural history of hypertensive heart disease (HHD) and aortic stenosis (AS). Once these patients develop severe left ventricular systolic dysfunction (LVSD) despite guideline-directed therapy for heart failure (HF), it is often thought to be end-stage from irreversible adverse remodelling. Our case series challenges this traditional paradigm. Read More

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A rare case of concomitant aortic regurgitation and coronary ostial stenosis due to cardiovascular syphilis.

Eur Heart J Case Rep 2021 Mar 2;5(3):ytab064. Epub 2021 Mar 2.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 6500017, Japan.

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Severe chronic aortic regurgitation after percutaneous coronary intervention: a case report and literature review.

Eur Heart J Case Rep 2021 Mar 3;5(3):ytab044. Epub 2021 Mar 3.

Department of Cardiothoracic Surgery and Anesthesiology, Entrance 50, 7th Floor, Uppsala University Hospital, SE-75185 Uppsala, Sweden.

Background: Severe aortic regurgitation (AR) is an extremely rare complication after coronary catheterization and percutaneous coronary intervention (PCI), where most reported cases have required relatively urgent surgical intervention due to acute-onset AR and cardiac decompensation.

Case Summary: We report a case of a 60-year-old woman that previously presented with a non-ST-elevation myocardial infarction (NSTEMI) due to an ostial right coronary artery stenosis. During the course of 2 years, she developed five recurrent NSTEMI due to in-stent thrombosis, necessitating either a new coronary stent or balloon. Read More

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Small Annulus, Hemodynamic Status, and TAVR.

JACC Cardiovasc Interv 2021 Jun;14(11):1229-1230

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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Predictors and Clinical Impact of Prosthesis-Patient Mismatch After Self-Expandable TAVR in Small Annuli.

JACC Cardiovasc Interv 2021 Jun;14(11):1218-1228

Division of Cardiology, Montefiore Medical Center, Bronx, New York, USA.

Objectives: The aim of this study was to define predictors of prosthesis-patient mismatch (PPM) and its impact on mortality after transcatheter aortic valve replacement (TAVR) with self-expandable valves (SEVs) in patients with small annuli.

Background: TAVR seems to reduce the risk for PPM compared with surgical aortic valve replacement, especially in patients with small aortic annuli. Nevertheless, predictors and impact of PPM in this population have not been clarified yet. Read More

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Transcatheter Versus Surgical Aortic Valve Replacement in Young, Low-Risk Patients With Severe Aortic Stenosis.

JACC Cardiovasc Interv 2021 Jun;14(11):1169-1180

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA. Electronic address:

Transcatheter aortic valve replacement (TAVR) is approved for all patient risk profiles and is an option for all patients irrespective of age. However, patients enrolled in the low- and intermediate-risk trials were in their 70s, and those in the high-risk trials were in their 80s. TAVR has never been systematically tested in young (<65 years), low-risk patients. Read More

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AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction.

J Am Coll Cardiol 2021 Jun;77(23):2923-2935

Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University of Munich, Munich, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address:

Background: Pathological cardiac hypertrophy is a result of afterload-increasing pathologies including untreated hypertension and aortic stenosis. It features progressive adverse cardiac remodeling, myocardial dysfunction, capillary rarefaction, and interstitial fibrosis often leading to heart failure.

Objectives: This study aimed to establish a novel porcine model of pressure-overload-induced heart failure and to determine the effect of inhibition of microribonucleic acid 132 (miR-132) on heart failure development in this model. Read More

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Safety and feasibility of retrograde INOUE-BALLOON for balloon aortic valvuloplasty without rapid ventricular pacing during transcatheter aortic valve replacement.

Cardiovasc Interv Ther 2021 Jun 10. Epub 2021 Jun 10.

Division of Cardiology, Department of Internal Medicine, Iwate Medical University, 2-1-1, Idaidori, Yahaba, Iwate, 028-3694, Japan.

Rapid ventricular pacing (RVP) is commonly employed during transcatheter aortic valve replacement (TAVR); however, frequent TAVR is associated with worse prognoses. The retrograde INOUE-BALLOON (IB) allows balloon aortic valvuloplasty (BAV) without RVP. The aim of this study was to evaluate the feasibility of retrograde IB for TAVR preparation. Read More

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Case report: iatrogenic left ventricular outflow tract to right atrium fistula after trans-femoral transcatheter aortic valve implantation associated with asymmetric septal hypertrophy.

Eur Heart J Case Rep 2021 Mar 10;5(3):ytab020. Epub 2021 Mar 10.

Department of Cardiology, University Hospital of Brest, Tanguy Prigent Boulevard, 29609 Brest Cedex, France.

Background : The transcatheter aortic valve implantation (TAVI) is becoming a leading treatment option for symptomatic aortic stenosis for patients in all surgical risk categories. Recognition and management of potential complications are essential to ensure patient life and comfort. We present here a case report of a left ventricular outflow tract (LVOT) to right atrium (RA) fistula which is an extremely rare complication after TAVI. Read More

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Repeated transcatheter aortic valve implantation for the treatment of a degenerated transcatheter aortic valve implantation valve (valve-in-valve technique): a case report.

Eur Heart J Case Rep 2020 Dec 23;4(6):1-6. Epub 2020 Oct 23.

Division of Interventional Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou av, 176 74 Athens, Greece.

Background: Valve-in-valve transcatheter aortic valve implantation (TAVI) has emerged as a competent alternative for the treatment of degenerated bioprosthetic valves after surgical aortic valve replacement, or during TAVI procedure as a bailout option. Herein, we report a rare case of a self-expandable Medtronic Evolut R valve into a failing Medtronic CoreValve, with the use of modern pre-TAVI imaging screening, suggesting the proper procedural design steps for so complicated implantations.

Case Summary: A frail 78-year-old woman with a degenerated Medtronic Core Valve 26 mm bioprosthesis, implanted in 2011 due to severe aortic stenosis, was referred to our hospital due to worsening dyspnoea New York Heart Association III. Read More

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December 2020

Cardiac Involvement in Facioscapulohumeral Muscular Dystrophy (FSHD).

Front Neurol 2021 24;12:668180. Epub 2021 May 24.

Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common muscular dystrophies and predominantly affects facial and shoulder girdle muscles. Previous case reports and cohort studies identified minor cardiac abnormalities in FSHD patients, but their nature and frequency remain incompletely characterized. We reviewed cardiac, neurological and genetic findings of 104 patients with genetically confirmed FSHD. Read More

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First-phase ejection fraction by cardiovascular magnetic resonance predicts outcomes in aortic stenosis.

J Cardiovasc Magn Reson 2021 Jun 10;23(1):73. Epub 2021 Jun 10.

British Heart Foundation Centre of Research Excellence, King's College London, London, UK.

Background: First-phase ejection fraction (EF1; the ejection fraction measured during active systole up to the time of maximal aortic flow) measured by transthoracic echocardiography (TTE) is a powerful predictor of outcomes in patients with aortic stenosis. We aimed to assess whether cardiovascular magnetic resonance (CMR) might provide more precise measurements of EF1 than TTE and to examine the correlation of CMR EF1 with measures of fibrosis.

Methods: In 141 patients with at least mild aortic stenosis, we measured CMR EF1 from a short-axis 3D stack and compared its variability with TTE EF1, and its associations with myocardial fibrosis and clinical outcome (aortic valve replacement (AVR) or death). Read More

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Endovascular interventions in main renal artery pathologies: an overview and update.

Acta Radiol 2021 Jun 9:2841851211019806. Epub 2021 Jun 9.

Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Renal arteries are involved in a wide spectrum of pathologies including atherosclerosis, fibromuscular dysplasia, Takayasu arteritis, aneurysms, and aortic type B dissections extending into main renal arteries. They manifest as renovascular hypertension, renal ischemia, and cardiovascular dysfunction. The location of the renal arteries in relation to the abdominal aortic aneurysm is a critical determinant of interventional options and long-term prognosis. Read More

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Balloon Aortic Valvuloplasty for Severe Aortic Stenosis Before Urgent Noncardiac Surgery.

EuroIntervention 2021 Jun 8. Epub 2021 Jun 8.

CHU Lille, Institut Coeur Poumon, Cardiology, Department of Interventional Cardiology for Coronary, Valves and Structural Heart Diseases, Lille, France.

Background: Balloon aortic valvuloplasty (BAV) has been proposed as a therapeutic option in patients suffering from severe aortic stenosis (SAS) who need urgent noncardiac surgery (NCS). Whether this strategy is better than medical therapy in this very peculiar population is unknown.

Aims: We evaluated the clinical benefit of an invasive strategy (IS) with preoperative BAV in patients with SAS requiring urgent NCS. Read More

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Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release.

Eur Heart J 2021 Jun 9. Epub 2021 Jun 9.

DZHK, Munich Partner Site, Ismaninger Str. 22, 81675 Munich, Germany.

Aims : Increased shedding of extracellular vesicles (EVs)-small, lipid bilayer-delimited particles with a role in paracrine signalling-has been associated with human pathologies, e.g. atherosclerosis, but whether this is true for cardiac diseases is unknown. Read More

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The relationship between aortic calcification on chest radiograph and neurocognitive impairment after coronary artery bypass grafting.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):166-173. Epub 2021 Apr 26.

Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey.

Background: In this study, we aimed to investigate the possible relationship between aortic calcification as detected by preoperative chest radiography and postoperative neurocognitive impairment in patients undergoing coronary artery bypass grafting.

Methods: A total of 124 patients (101 males, 23 females; mean age: 59.9±8. Read More

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Results of balloon and surgical valvuloplasty in congenital aortic valve stenosis: A 19-year, single-center, retrospective study.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):158-165. Epub 2021 Apr 26.

Department of Cardiovascular Surgery, Başkent University Faculty of Medicine, Ankara, Turkey.

Background: This study aims to compare the success, complications, and long-term outcomes of aortic balloon valvuloplasty and surgical aortic valvuloplasty in pediatric patients with congenital aortic valve stenosis.

Methods: Between March 2000 and October 2019, a total of 267 procedures, including 238 balloon valvuloplasties and 29 surgical valvuloplasties, in 198 children (135 males, 63 females; mean age: 57.4±62. Read More

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Rapid progression of aortic stenosis in a 3-month-old infant with bicuspid aortic valve and DeSanto-Shinawi syndrome.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):208-210. Epub 2021 Mar 26.

Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan, Wayne State University, Detroit, MI, USA.

A 3-month-old female was diagnosed at 1 month of age with DeSanto-Shinawi syndrome (DSS) and bicuspid aortic valve with trivial stenosis. The aortic valve stenosis progressed to severe within 2 months and required balloon aortic valvuloplasty. This is the first case of aortic stenosis (AS) associated with DSS, and the syndrome may be the reason for the rapid worsening of AS in this case. Read More

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Life expectancy after aortic valve replacement in young patients.

Rev Esp Cardiol (Engl Ed) 2021 Jun 5. Epub 2021 Jun 5.

Servicio de Cirugía Cardiaca, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

Introduction And Objectives: In young patients with severe aortic stenosis, it is unknown whether their life expectancy restored after aortic valve replacement (AVR) is unknown.

Methods: We analyzed all patients aged between 50 and 65 years who underwent isolated AVR in 27 Spanish centers during an 18-year period. We compared observed and expected survival at 15 years of follow-up. Read More

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Stenotic lesions of aorta: Imaging evaluation using multidetector computed tomography angiography.

Asian Cardiovasc Thorac Ann 2021 Jun 8:2184923211024094. Epub 2021 Jun 8.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

Aortic involvement can be secondary to various pathologic disease processes. These may result in stenotic or aneurysmal aortic lesions with a varied spectrum of imaging findings including intra-luminal, mural, and periaortic changes along with associated loco-regional or distal changes, depending on the etiology. Multidetector computer tomography with its recent advances has become the frontline imaging modality for the evaluation of aortic pathologies. Read More

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Deoxyribonuclease is prognostic in patients undergoing transcatheter aortic valve replacement.

Eur J Clin Invest 2021 Jun 8:e13595. Epub 2021 Jun 8.

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.

Degenerative aortic valve stenosis is an inflammatory process that resembles atherosclerosis. Neutrophils release their DNA upon activation and form neutrophil extracellular traps (NETs), which are present on degenerated aortic valves. NETs correlate with pressure gradients in severe aortic stenosis. Read More

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Sex-Specific Molecular Signatures of Fibrocalcific Aortic Valve Disease: Leveraging the Power of Artificial Intelligence?

JACC Basic Transl Sci 2021 May 24;6(5):413-415. Epub 2021 May 24.

Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany.

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Comparison of long-term mortality in patients who underwent transcatheter aortic valve replacement with or without anti-atherosclerotic therapy.

Heart Vessels 2021 Jun 8. Epub 2021 Jun 8.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Atherosclerosis is a risk factor for both aortic stenosis (AS) and coronary artery disease. This study aimed to investigate whether anti-atherosclerotic therapy (AT), defined as the simultaneous use of antiplatelet agents, statins, and renin aldosterone system inhibitors, had long-term clinical benefits for patients who underwent transcatheter aortic valve replacement (TAVR). Between October 2013 and May 2017, 2518 patients (31% men; median age, 85 years) who underwent TAVR in 14 Japanese centers were divided into two groups: patients who were prescribed anti-atherosclerotic therapy (AT, n = 567) and patients who were not (no AT, n = 1951). Read More

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Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis.

Sci Rep 2021 Jun 7;11(1):11975. Epub 2021 Jun 7.

Department of Health Policy, London School of Economics, London, UK.

Transcatheter aortic valve replacement (TAVR) has shown to reduce mortality compared to surgical aortic valve replacement (sAVR). However, it is unknown which procedure is associated with better post-procedural valvular function. We conducted a meta-analysis of randomized clinical trials that compared TAVR to sAVR for at least 2 years. Read More

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