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    Impact of right ventricular function on outcome of severe aortic stenosis patients undergoing transcatheter aortic valve replacement.
    Am Heart J 2017 Feb 29;184:141-147. Epub 2016 Oct 29.
    Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC. Electronic address:
    Background: Right ventricular (RV) dysfunction was shown to be associated with adverse outcomes in a variety of cardiac patients and is considered a risk factor for adverse outcome according to the updated Valve Academic Research Consortium criteria.

    Objective: Our goal was to assess the impact of RV function at baseline on 1-year mortality among patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).

    Methods: All patients with severe AS treated with TAVR from May 2007 to March 2015 at our center were included in the present study, and baseline and procedural characteristics were recorded for each patient. Read More

    A Potential Oligogenic Etiology of Hypertrophic Cardiomyopathy, A Classic Single Gene Disorder.
    Circ Res 2017 Feb 21. Epub 2017 Feb 21.
    Center for Cardiovascular Genetics, University of Texas Health Sciences Center at Houston
    Rationale: Hypertrophic cardiomyopathy (HCM) is a prototypic single gene disease caused mainly by mutations in genes encoding sarcomere proteins. Despite the remarkable advances, the causal genes in about 40% of the HCM cases remain unknown, typically in small families and sporadic cases, wherein co-segregation could not be established. Objective: To test the hypothesis that the "missing causal genes" in HCM is, in part, because of an oligogenic etiology, wherein the pathogenic variants do not co-segregate with the phenotype. Read More

    The neurologic protection of unilateral versus bilateral antegrade cerebral perfusion in aortic arch surgery with deep hypothermic circulatory arrest: A study of 77 cases.
    Int J Surg 2017 Feb 20;40:8-13. Epub 2017 Feb 20.
    Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, PR China. Electronic address:
    Backgroud: Unilateral and bilateral antegrade cerebral perfusions (ACP) are recognized methods of cerebral protection in aortic arch surgery. However, the adequacy of cerebral protection in aortic arch surgery with deep hypothermic circulatory arrest is controversial. In this study, we compared unilateral and bilateral ACP of cerebral protection in aortic arch surgery by assessing the patient's intraoperative and postoperative brain function. Read More

    Transcatheter Aortic Valve-in-Valve Implantation Using Lotus Valve for Failed Surgical Bioprostheses.
    Ann Thorac Surg 2017 Feb 18. Epub 2017 Feb 18.
    Cardiovascular Unit, Maria Cecilia Hospital, GVM Care and Research, Cotignola, Ravenna, Italy.
    Background: Patients with failed bioprostheses are an increasing population at high risk for redo surgery. Valve-in-valve transcatheter aortic valve implantation is a promising alternative but a limited number of first-generation devices have proven efficacy in all cases.

    Methods: Patients with degenerated bioprostheses at high risk for redo surgery were included in the registry after being assigned to valve-in-valve intervention by a local heart team. Read More

    The impact of trans-catheter aortic valve replacement induced left-bundle branch block on cardiac reverse remodeling.
    J Cardiovasc Magn Reson 2017 Feb 22;19(1):22. Epub 2017 Feb 22.
    Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK.
    Background: Left bundle branch block (LBBB) is common following trans-catheter aortic valve replacement (TAVR) and has been linked to increased mortality, although whether this is related to less favourable cardiac reverse remodeling is unclear. The aim of the study was to investigate the impact of TAVR induced LBBB on cardiac reverse remodeling.

    Methods: 48 patients undergoing TAVR for severe aortic stenosis were evaluated. Read More

    Impact of Coronary Artery Disease Severity Assessed With the SYNTAX Score on Outcomes Following Transcatheter Aortic Valve Replacement.
    J Am Heart Assoc 2017 Feb 20;6(2). Epub 2017 Feb 20.
    Cardiovascular Research Foundation, New-York, NY
    Background: The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR.

    Methods And Results: A total of 377 patients who underwent TAVR in 2 high-volume centers in North America were included in our retrospective analysis. Read More

    IgG4-Related Disease Causing Rapid Evolution of a Severe Aortic Valvular Stenosis.
    Ann Thorac Surg 2017 Mar;103(3):e239-e240
    Department of Cardiovascular and Thoracic Surgery, University Hospital of Liège, Liège, Belgium; Surgical Research Center, GIGA-R, University of Liège, Liège, Belgium. Electronic address:
    Immunoglobulin G4-related systemic disease (IgG4-RSD) is a recognized emerging entity characterized by chronic fibroinflammation that can affect every organ but rarely affects the cardiovascular system. We report a rare case of IgG4-RSD involving an aortic valve that resulted in rapid progression of an aortic valvular stenosis and was successfully treated by aortic valve replacement and corticosteroids. Read More

    Concomitant Endografting of a Type B Aortic Dissection During Transfemoral Aortic Valve Replacement.
    Ann Thorac Surg 2017 Mar;103(3):e223-e224
    Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
    An 87-year-old woman with severe aortic stenosis underwent a transfemoral transcatheter aortic valve replacement (TAVR). Intraoperative transesophageal echocardiography demonstrated a well-seated valve with no paravalvular leak; however, a new acute type B aortic dissection was identified. Endografts were delivered through the TAVR sheath and deployed, effectively treating the dissection. Read More

    Renal artery revascularization by using the Riolan anastomosis as feeding vessel in a patient with abdominal aortic coarctation due to fibromuscular dysplasia.
    Vasa 2017 Feb 20:1-6. Epub 2017 Feb 20.
    1 Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Germany.
    Fibromuscular dysplasia is a non-inflammatory, non-atherosclerotic vascular disease, occurring predominantly in younger females. A histologically heterogeneous group of fibroplasia without an inflammatory component causes arterial narrowing. It affects mostly one or both renal arteries, cervicocranial or visceral arteries, leading to hypertension, renal failure/renal infarction or stroke/transient ischaemic attack. Read More

    Gastric antral vascular ectasia in systemic sclerosis: Where do we stand?
    Int J Rheum Dis 2017 Feb 20. Epub 2017 Feb 20.
    Rheumatology & Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Gastric antral vascular ectasia (GAVE) continues to be a challenge in both diagnosis and treatment. GAVE has a diverse group of associations and presumed causes, including cirrhosis, chronic renal failure and autoimmune connective tissue diseases. However, in most occasions, the management plan of GAVE itself is the same whatever the underlying disease by using Argon plasma coagulation (APC). Read More

    First reported case of fetal aortic valvuloplasty in Asia.
    Obstet Gynecol Sci 2017 Jan 19;60(1):106-109. Epub 2017 Jan 19.
    Department of Pediatric Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    Prenatal intervention of severe fetal aortic valve stenosis by ultrasound-guided percutaneous balloon valvuloplasty has been performed to prevent the progression to hypoplastic left heart syndrome, and achieve biventricular circulation in neonates. Here we report a case of fetal aortic valvuloplasty prenatally diagnosed with aortic stenosis at 24 weeks of gestation and showed worsening features on a follow-up echocardiography. Prenatal aortic valvuloplasty was performed at 29 weeks of gestation, and was a technical success. Read More

    The fate of endovascular aortic aneurysm repair after 5 years monitored with duplex ultrasound imaging.
    J Vasc Surg 2017 Feb 16. Epub 2017 Feb 16.
    Section of Vascular Surgery, Danbury Hospital, Danbury, Conn.
    Background: Interventions for aortic aneurysm sac growth have been reported across multiple time points after endovascular aortic aneurysm repair (EVAR). We report the long-term outcomes of patients after EVAR monitored with duplex ultrasound (DUS) imaging with respect to the need for and type of intervention after 5 years.

    Methods: We report a series of patients who were monitored with DUS imaging for a minimum of 5 years after EVAR. Read More

    Role of Myocardial Collagen in Severe Aortic Stenosis With Preserved Ejection Fraction and Symptoms of Heart Failure.
    Rev Esp Cardiol (Engl Ed) 2017 Feb 16. Epub 2017 Feb 16.
    Servicio de Cardiología, Hospital Universitario Donostia, Universidad del País Vasco, San Sebastián, Guipúzcoa, Spain; Área de Enfermedades Sistémicas, Instituto de Investigación Biodonostia, San Sebastián, Guipúzcoa, Spain. Electronic address:
    Introduction And Objectives: We investigated the anatomical localization, biomechanical properties, and molecular phenotype of myocardial collagen tissue in 40 patients with severe aortic stenosis with preserved ejection fraction and symptoms of heart failure.

    Methods: Two transmural biopsies were taken from the left ventricular free wall. Mysial and nonmysial regions of the collagen network were analyzed. Read More

    Outcome of patients undergoing TAVR with and without the attendance of an anesthesiologist.
    Int J Cardiol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Cardiology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
    Background: During the last few years there is a shift from performing Transcatheter Aortic Valve Replacement (TAVR) under general anesthesia towards conscious sedation and local anesthesia only. In the vast majority of centers, sedation is guided by a qualified anesthesiologist. In our center, all TAVR procedures are being performed under local anesthesia and mild sedation, however, since September 2014, a large portion of TAVR procedures are being performed under local anesthesia without the presence of an anesthesiologist. Read More

    INNOVATION: Four-year safety and effectiveness of the INCRAFT® AAA Stent Graft for endovascular repair of abdominal aortic aneurysms.
    J Cardiovasc Surg (Torino) 2017 Feb 17. Epub 2017 Feb 17.
    St. Franziskus Hospital and University Clinic of Muenster, Muenster, Germany.
    Background: This paper reports the 4-year safety and effectiveness of the INCRAFT® AAA Stent Graft system (Cordis Corp, Milpitas, CA), an ultra-low-profile device for the treatment of abdominal aortic aneurysms.

    Methods: The INNOVATION Trial is the prospective, first-in-human, multicenter trial to evaluate the safety and effectiveness of the INCRAFT® System. Patients underwent annual clinical and CTA examination as part of the study protocol. Read More

    Pre-Implantation Balloon Aortic Valvuloplasty and Clinical Outcomes Following Transcatheter Aortic Valve Implantation: A Propensity Score Analysis of the UK Registry.
    J Am Heart Assoc 2017 Feb 18;6(2). Epub 2017 Feb 18.
    Health e-Research Centre, University of Manchester, Manchester, United Kingdom
    Background: Aortic valve predilation with balloon aortic valvuloplasty (BAV) is recommended before transcatheter aortic valve implantation (TAVI), despite limited data around the requirement of this preprocedural step and the potential risks of embolization. This study aimed to investigate the trends in practice and associations of BAV on short-term outcomes in the UK TAVI registry.

    Methods And Results: Eleven clinical endpoints were investigated, including 30-day mortality, myocardial infarction, aortic regurgitation, valve dysfunction, and composite early safety. Read More

    Association of warfarin with congestive heart failure and peripheral artery occlusive disease in hemodialysis patients with atrial fibrillation.
    J Chin Med Assoc 2017 Feb 14. Epub 2017 Feb 14.
    Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Institutes of Physiology and Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address:
    Background: The effect of warfarin on the risk of cardiovascular (CV) disease is unknown among chronic hemodialysis patients with atrial fibrillation (HD-AF).

    Methods: Population-based propensity score and prescription time-distribution matched cohort study including 6719 HD-AF patients with CHA2DS2-VASc score ≥ 2 were divided into warfarin users and nonusers and followed-up for CV events and death.

    Results: Warfarin treatment in HD-AF patients with AF preceding HD was associated with higher risks of developing congestive heart failure [hazard ratio (HR)=1. Read More

    Temporal Dissociation between Minimal Distal-to-Aortic Pressure Ratio and Peak Hyperemia during Intravenous Adenosine Infusion.
    Am J Physiol Heart Circ Physiol 2017 Feb 17:ajpheart.00632.2016. Epub 2017 Feb 17.
    Academic Medical Center, University of Amsterdam
    The present study sought to compare the temporal relation between maximal coronary flow (peak hyperemia) and minimal coronary/aortic (Pd/Pa) pressure ratio for intracoronary (IC) and intravenous (IV) adenosine administration. Peak hyperemia is assumed to coincide with the minimal Pd/Pa value. However, this has not been confirmed for systemic hemodynamic variations during IV adenosine infusion. Read More

    [Reintervention with percutaneous balloon angioplasty in patients with congenital heart disease with left-sided obstructions].
    Rev Med Inst Mex Seguro Soc 2017 ;55 Suppl 1:S86-S91
    Servicio de Cardiopatías Congénitas, Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.
    Background: Left-sided cardiac obstructions represent 15% of congenital heart disease (CHD). The treatment in adults is surgical; however, balloon dilation by interventional catheterization can alleviate the symptoms in pediatric patients to allow them to reach the target height. The aim was to determine the survival and the factors associated with reintervention in patients with CHD with left-sided obstruction treated with balloon angioplasty. Read More

    End-stage renal disease and severe aortic stenosis: Does valve replacement improve one-year outcomes?
    Catheter Cardiovasc Interv 2017 Feb 17. Epub 2017 Feb 17.
    Structural Heart and Valve Center, Divisions of Cardiology, Emory University School of Medicine, Atlanta, Georgia.
    Background: Treatment for patients with end-stage renal disease (ESRD) and severe aortic stenosis (AS) includes balloon aortic valvuloplasty (BAV), surgical (SAVR), or transcatheter (TAVR) aortic valve replacement. We compared outcomes among these strategies.

    Methods: A retrospective review of patients with ESRD undergoing treatment for severe AS between 07/2007 and 06/2015 was performed at our center. Read More

    Quantifying Aortic Valve Calcification using Coronary Computed Tomography Angiography.
    J Cardiovasc Comput Tomogr 2017 Jan 30. Epub 2017 Jan 30.
    Division of Cardiology, University of Ottawa Heart Institute, Canada; Department of Radiology, University of Ottawa, Canada. Electronic address:
    Introduction: Aortic valve calcification (AVC) has been associated with major adverse cardiovascular events and all-cause mortality. We sought to develop and validate a method to quantify AVC using coronary CT angiography (CTA).

    Methods: Of 59 patients who underwent both non-contrast and contrast enhanced coronary CTA, 25 patients served as the derivation cohort and 34 patients served as the validation cohort. Read More

    The feasibility of transcatheter aortic valve implantation using the Edwards SAPIEN 3 for patients with severe bicuspid aortic stenosis.
    J Cardiol 2017 Feb 10. Epub 2017 Feb 10.
    Ramsay Générale de Santé, Institut Cardiovasculaire Paris Sud, Hôpital Privé Jacques Cartier, Massy, France.
    Background: There are currently only limited data focusing on transcatheter aortic valve implantation (TAVI) for bicuspid aortic valves (BAV) patients using the Edwards SAPIEN (Irvine, CA, USA) 3 (S3) valve. The aim of this study was to evaluate the feasibility and efficacy of TAVI using the S3 in patients with BAV.

    Methods: A total of 153 TAVI cases performed with the S3 were included. Read More

    Percutaneous Transcatheter Therapies for the Management of Left Ventricular Assist Device Complications.
    J Invasive Cardiol 2017 Feb 15. Epub 2017 Feb 15.
    The University of Chicago Medicine, 5841 S. Maryland Ave, MC 6080, Chicago, IL 60637 USA.
    Heart failure is a growing epidemic in the United States and throughout the world. The utilization of continuous-flow left ventricular assist devices (LVADs) has greatly increased over the last decade. In addition, a limited supply of organ donors has led to a rise in the use, and duration, of LVADs for destination therapy. Read More

    Robotic trans-atrial and trans-mitral ventricular septal resection.
    Ann Cardiothorac Surg 2017 Jan;6(1):54-59
    Department of Cardiovascular Sciences, East Carolina Heart Institute, East Carolina University & Vidant Medical Center, Greenville, North Carolina, USA.
    Localized ventricular septal hypertrophy, also known as idiopathic hypertrophic subaortic stenosis or idiopathic hypertrophic subaortic septal obstruction (IHSS), can create severe ventricular outflow obstruction. This often results in a high sub-aortic pressure gradient with potentially lethal symptoms. In 1960, Braunwald described the hemodynamic characteristics of IHSS, and thereafter, Morrow developed a trans-aortic approach to resect a large part of the ventricular septum, enlarging the outflow tract. Read More

    Morphotype-Dependent Flow Characteristics in Bicuspid Aortic Valve Ascending Aortas: A Benchtop Particle Image Velocimetry Study.
    Front Physiol 2017 1;8:44. Epub 2017 Feb 1.
    Department of Mechanical and Materials Engineering, Wright State University Dayton, OH, USA.
    The bicuspid aortic valve (BAV) is a major risk factor for secondary aortopathy such as aortic dilation. The heterogeneous BAV morphotypes [left-right-coronary cusp fusion (LR), right-non-coronary cusp fusion (RN), and left-non-coronary cusp fusion (LN)] are associated with different dilation patterns, suggesting a role for hemodynamics in BAV aortopathogenesis. However, assessment of this theory is still hampered by the limited knowledge of the hemodynamic abnormalities generated by the distinct BAV morphotypes. Read More

    Left intraventricular pressure gradients improvement after aortic valve replacement in aortic stenosis patients.
    Exp Physiol 2017 Feb 14. Epub 2017 Feb 14.
    Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Unit, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
    The present study was conducted to characterize left intraventicular pressure gradients, a marker of normal cardiac function, in patients with severe aortic stenosis, a condition which interferes with ventricular filling and emptying. In 10 patients (4 male; mean age 71.3 ± 4. Read More

    Local anaesthesia with analgosedation in patients qualified for transcatheter aortic valve implantation (TAVI): first institute's results and experiments.
    Anaesthesiol Intensive Ther 2017 Feb 14. Epub 2017 Feb 14.
    Department of Anaesthesiology and Intensive Therapy, John Paul II Hospital, Cracow, Poland.
    Background: The authors present their own experience of the treatment of patients qualified for transcatheter aortic valve implantation (TAVI) carried out in a modern hybrid operating room. The objective of the present study was to demonstrate the initial results of conducting anaesthesia in high-risk patients qualified for the TAVI procedure (transcatheter aortic valve implantation). In addition, the authors' aim was also to point out to the special challenges of an anaesthesiologist conducting local anaesthesia in such a type of procedures and to evaluate the safety and efficacy of the TAVI procedure conducted under remifentanil analgosedation. Read More

    Impact of Pulmonary Hypertension on Outcome in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.
    Clin Res Cardiol 2017 Feb 14. Epub 2017 Feb 14.
    Service Cardiologie, CHU Limoges, Hôpital Dupuytren, Limoges, 87042, France.
    Aims: The prognostic impact of elevated pulmonary arterial pressure (PAP) remains controversial in aortic stenosis (AS) and few studies focused on patients with preserved left ventricular ejection fraction (LVEF). We aimed to investigate the impact of pulmonary hypertension (PH), invasively derived, on survival in severe AS with preserved LVEF.

    Methods And Results: Between 2000 and 2010, 749 patients (74 ± 8 years, 57% males) with preserved LVEF and severe AS without other valvular heart disease underwent cardiac catheterization. Read More

    Deletion of CD73 in mice leads to Aortic Valve Dysfunction.
    Biochim Biophys Acta 2017 Feb 10. Epub 2017 Feb 10.
    Department of Biochemistry, Medical University of Gdansk. Electronic address:
    Aortic stenosis is known to involve inflammation and thrombosis. Changes in activity of extracellular enzyme - ecto-5'-nucleotidase (referred also as CD73) can alter inflammatory and thrombotic responses. This study aimed to evaluate the effect of CD73 deletion in mice on development of aortic valve dysfunction and to compare it to the effect of high-fat diet. Read More

    Patient-specific assessment of hemodynamics by computational fluid dynamics in patients with bicuspid aortopathy.
    J Thorac Cardiovasc Surg 2017 Jan 11. Epub 2017 Jan 11.
    Division of Cardiovascular Surgery, Department of Surgery, Jichi Medical University, Saitama, Japan.
    Objective: Hemodynamics related to eccentric blood flow may factor into the development of bicuspid aortic valve aortopathy. We investigated wall shear stress distribution by means of magnetic resonance imaging-based computational fluid dynamics in patients with a bicuspid aortic valve.

    Methods: Included were 12 patients with a bicuspid aortic valve (aortic stenosis, n = 11; root enlargement, n = 1). Read More

    A pathological complete response after combined chemotherapy of gemcitabine and S-1 in advanced biliary tract cancer with para-aortic lymph nodes metastasis: a case report.
    Surg Case Rep 2017 Dec 12;3(1):26. Epub 2017 Feb 12.
    Department of Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
    Background: Biliary tract cancer is a rare malignancy that carries poor prognosis. Complete surgical resection is the only curable treatment. However, biliary tract cancer patients are often diagnosed with advanced stages and treated in systemic chemotherapy or palliative treatment settings rather than curative surgery. Read More

    Does pre-existing aortic regurgitation protect from death in patients who develop paravalvular leak after TAVI?
    Int J Cardiol 2017 Apr 4;233:52-60. Epub 2017 Feb 4.
    Division of Cardiac Surgery, San Giovanni Battista Hospital 'Molinette', University of Turin, Turin, Italy.
    Objective: The aim of this study was to investigate interactions among pre-procedural aortic regurgitation (AR), post-procedural paravalvular leak (PVL) and long-term clinical outcomes.

    Methods And Results: We analyzed data prospectively collected in the Italian Transcatheter balloon-Expandable Registry (ITER) on aortic stenosis (AS) patients. The degree of pre-procedural AR and post-procedural PVL was stratified as: absent/trivial, mild, and moderate/severe. Read More

    Bicuspid Aortic Valve Morphotype Correlates With Regional Antioxidant Gene Expression Profiles in the Proximal Ascending Aorta.
    Ann Thorac Surg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Bioengineering, McGowan Institute for Regenerative Medicine, and Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:
    Background: Bicuspid aortic valve (BAV) is associated with asymmetric dilatation of the proximal ascending aorta. We previously demonstrated increased susceptibility of smooth muscle cells to oxidative stress in the BAV-aneurysmal aorta and hypothesized that antioxidant expression is regionally defined and influenced by the BAV morphotype.

    Methods: BAV valve morphology was defined according to number of raphes: type 0 (0 raphes), type 1 (1 raphe), or type 2 (2 raphes) and by the raphe location among the left (L), right (R) or non (N) coronary cusps. Read More

    The role of adjunctive procedures in reducing postoperative tracheobronchial obstruction in single lung patients with congenital tracheal stenosis undergoing slide tracheoplasty.
    J Pediatr Surg 2017 Jan 27. Epub 2017 Jan 27.
    Takatsuki General Hospital, Takatsuki, Japan.
    Purpose: Congenital tracheal stenosis (CTS) and a single right lung treated with slide tracheoplasty (ST) has relatively high rates of mortality and morbidity. We report a single institution's experience with adjunctive procedures at the time of ST to reduce postoperative tracheal obstruction in patients with a single right lung and CTS.

    Methods: With IRB approval, 8 patients with a single right lung and CTS who underwent ST in our institution between 2008 and 2016 were reviewed. Read More

    Clinical information has low sensitivity for postmortem diagnosis of heart valve disease.
    Heart 2017 Feb 9. Epub 2017 Feb 9.
    Department of Cardiology, St Thomas' Hospital, London, UK
    Background: Accuracy of routinely collected information concerning cause of death is essential for public health and health systems planning. Since clinical examination has relatively low sensitivity for detection of valvular heart disease (VHD), mortality data based on clinical information alone might routinely underestimate the number of deaths due to VHD.

    Methods: We compared autopsy findings against premortem clinical information for 8198 consecutive adult postmortems (mean age 69. Read More

    A Test in Context: Lipoprotein(a): Diagnosis, Prognosis, Controversies, and Emerging Therapies.
    J Am Coll Cardiol 2017 Feb;69(6):692-711
    Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, California. Electronic address:
    Evidence that elevated lipoprotein(a) (Lp[a]) levels contribute to cardiovascular disease (CVD) and calcific aortic valve stenosis (CAVS) is substantial. Development of isoform-independent assays, in concert with genetic, epidemiological, translational, and pathophysiological insights, have established Lp(a) as an independent, genetic, and likely causal risk factor for CVD and CAVS. These observations are consistent across a broad spectrum of patients, risk factors, and concomitant therapies, including patients with low-density lipoprotein cholesterol <70 mg/dl. Read More

    Initial Experience of a Second-Generation Self-Expanding Transcatheter Aortic Valve: The UK & Ireland Evolut R Implanters' Registry.
    JACC Cardiovasc Interv 2017 Feb;10(3):276-282
    Cardiology Clinical Academic Group, St. George's University Hospitals NHS Foundation Trust & St. George's University of London, London, United Kingdom. Electronic address:
    Objectives: The authors present the UK and Irish real-world learning curve experience of the Evolut R transcatheter heart valve.

    Background: The Evolut R is a self-expanding, repositionable, and fully recapturable second-generation transcatheter heart valve with several novel design features to improve outcomes and reduce complications.

    Methods: Clinical, procedural, and 30-day outcome data were prospectively collected for the first 264 patients to receive the Evolut R valve in the United Kingdom and Ireland. Read More

    Early Clinical Outcomes After Transcatheter Aortic Valve Replacement Using a Novel Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis Who Are Suboptimal for Surgery: Results of the Evolut R U.S. Study.
    JACC Cardiovasc Interv 2017 Feb;10(3):268-275
    Departments of Medicine (Cardiology) and Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York.
    Objectives: This study sought to evaluate this transcatheter aortic valve (TAV) bioprosthesis in patients who are poorly suitable for surgical aortic valve (AV) replacement.

    Background: A novel self-expandable TAV bioprosthesis was designed to provide a low-profile delivery system, conformable annular sealing, and the ability to resheath and reposition during deployment.

    Methods: The Evolut R U. Read More

    Cardiac Imaging for Assessing Low-Gradient Severe Aortic Stenosis.
    JACC Cardiovasc Imaging 2017 Feb;10(2):185-202
    Institut Universitaire de Cardiologie et de Pneumologie de Québec (Québec Heart and Lung Institute), Laval University, Québec, Québec, Canada. Electronic address:
    Up to 40% of patients with aortic stenosis (AS) harbor discordant Doppler-echocardiographic findings, the most common of which is the presence of a small aortic valve area (≤1.0 cm(2)) suggesting severe AS, but a low gradient (<40 mm Hg) suggesting nonsevere AS. The purpose of this paper is to present the role of multimodality imaging in the diagnostic and therapeutic management of this challenging entity referred to as low-gradient AS. Read More

    Bicuspid aortic valve aortopathy: mechanistic and clinical insights from recent studies.
    Curr Opin Cardiol 2017 Mar;32(2):111-116
    aSection of Cardiac Surgery, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, AlbertabDivision of Cardiac Surgery, Li Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, CanadacMartha and Richard Melman Family Bicuspid Aortic Valve Program, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois, USA.
    Purpose Of Review: This focused review summarizes key insights from the past 12 months of basic science and clinical research on bicuspid aortic valve (BAV)-associated aortopathy.

    Recent Findings: Recent studies in BAV-associated aortopathy support a heterogeneous spectrum of disease with distinct phenotypes. Basic science studies provide further support for the concept of regional differences in the severity of aortopathy within the aorta of BAV patients. Read More

    Management of iatrogenic aortal dissection as a complication of coronary intervention: wait and watch.
    Future Cardiol 2017 Mar 9;13(2):125-129. Epub 2017 Feb 9.
    Department of Cardiology, Evangelisches Krankenhaus, Mülheim (Ruhr), Germany.
    Iatrogenic aortic dissection (AD) is quite a rare complication during percutaneous coronary intervention (PCI). The exact mechanism of iatrogenic AD during PCI is unknown. A standard of care in the management of iatrogenic AD is still lacking. Read More

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