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    Doppler assessment of aortic stenosis: a 25-operator study demonstrating why reading the peak velocity is superior to velocity time integral.
    Eur Heart J Cardiovasc Imaging 2018 Jan 15. Epub 2018 Jan 15.
    Imperial College London, NHLI-Cardiovascular Science, Du Cane Road, London W12?0NN, UK.
    Aims: Measurements with superior reproducibility are useful clinically and research purposes. Previous reproducibility studies of Doppler assessment of aortic stenosis (AS) have compared only a pair of observers and have not explored the mechanism by which disagreement between operators occurs. Using custom-designed software which stored operators' traces, we investigated the reproducibility of peak and velocity time integral (VTI) measurements across a much larger group of operators and explored the mechanisms by which disagreement arose. Read More

    Echocardiographic criteria to detect unicuspid aortic valve morphology.
    Eur Heart J Cardiovasc Imaging 2018 Jan 15. Epub 2018 Jan 15.
    Klinik für Herz- und Thorax-Gefäß-Chirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str., Geb. 57, 66421 Homburg/Saar, Germany.
    Aims: Unicuspid aortic valve (UAV) is a rare congenital malformation associated with severe aortic stenosis or regurgitation. This study aimed to systematically determine echocardiographic criteria to identify UAV.

    Methods And Results: All patients underwent a preoperative baseline examination, including echocardiography. Read More

    Antithrombotic therapy after TAVR.
    Curr Vasc Pharmacol 2018 Jan 17. Epub 2018 Jan 17.
    University Hospital Tubingen - Department of Cardiology Tubingen. Germany.
    Transvascular aortic valve replacement (TAVR) has emerged as a treatment option in patients with severe aortic stenosis who are inoperable and has recently been evaluated in patients with intermediate surgical risk. The number of procedures is increasing worldwide in parallel with the demographic changes in industrial countries. The risk for cerebral embolism is of main concern and represents a major determinant for prognosis and quality of live after TAVR. Read More

    Aortic versus carotid intima-media thickness and impact of aortic valve disease.
    Clin Physiol Funct Imaging 2018 Jan 17. Epub 2018 Jan 17.
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
    Background And Aims: Intima-media thickness is a marker for atherosclerosis but is also influenced by shear stress and flow. We evaluated the relation between intima-media thickness of the descending aorta (AoIMT) and the common carotid artery (CIMT) in patients with and without severe aortic valve disease (sAVD).

    Methods: A total of 310 patients (233 with sAVD, 77 without) were examined with regard to AoIMT and CIMT using transesophageal echocardiography and carotid ultrasound, respectively, before valvular and/or aortic surgery. Read More

    Tissue expander-stimulated lengthening of arteries for the treatment of midaortic syndrome in children.
    J Vasc Surg 2018 Jan 13. Epub 2018 Jan 13.
    Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Mass.
    Background: Midaortic syndrome (MAS) is a rare condition characterized by stenosis of the abdominal aorta. Patients with disease refractory to medical management will usually require either endovascular therapy or surgery with use of prosthetic graft material for bypass or patch angioplasty. We report our early experience with a novel approach using a tissue expander (TE) to lengthen the normal native arteries in children with MAS, allowing primary aortic repair without the need for prosthetic graft material. Read More

    Subclinical left ventricular systolic dysfunction in patients with severe aortic stenosis: A speckle-tracking echocardiography study.
    Turk Kardiyol Dern Ars 2018 Jan;46(1):18-24
    Department of Cardiology, İstanbul Florence Nightingale Hospital, İstanbul, Turkey.
    Objective: In patients with aortic stenosis (AS), the left ventricular (LV) geometry changes due to the increased LV afterload. However, subclinical myocardial dysfunction can develop despite a normal LV ejection fraction (EF). This study was an investigation of subclinical LV systolic dysfunction in patients with severe AS with a normal LV EF using a strain imaging method, speckle-tracking echocardiography (STE), and an evaluation of its correlation with novel indices to assess the severity of AS. Read More

    General Anesthesia for Transcatheter Aortic Valve Replacement: Total Intravenous Anesthesia is Associated with Less Delirium as Compared to Volatile Agent Technique.
    J Cardiothorac Vasc Anesth 2017 Dec 11. Epub 2017 Dec 11.
    University of North Carolina, Department of Anesthesiology, Chapel Hill, NC.
    Objective: Investigate the effect of volatile anesthesia versus total intravenous anesthesia on the incidence of postoperative delirium and length of stay in patients undergoing transcatheter aortic valve replacement under general anesthesia.

    Design: Retrospective study.

    Setting: Single institution, academic medical center. Read More

    Transesophageal echocardiography evaluation of the aortic arch branches.
    Ann Card Anaesth 2018 Jan-Mar;21(1):53-56
    Department of Cardiac Anesthesiology, Fortis Hospitals, Bengaluru, Karnataka, India.
    Visualization of aortic arch branches by transesophageal echocardiography has been technically challenging. Visualizing these vessels helps in identifying the extent of dissection of the aorta, assessing the severity of carotid artery stenosis, presence of atheromatous plaques, patency of the left internal mammary artery graft, confirmation of subclavian artery cannulation, confirming holodiastolic flow reversal in the left subclavian artery by spectral Doppler imaging in case of severe aortic regurgitation, and confirming the optimal position of the intraaortic balloon perioperatively. The information obtained is helpful for diagnosis, monitoring, and decision-making during aortic surgery. Read More

    Reoperation for a giant arch anastomotic pseudoaneurysm eleven years after total arch replacement with island reconstruction.
    J Cardiothorac Surg 2018 Jan 15;13(1). Epub 2018 Jan 15.
    Department of Cardiovascular Surgery, Fukui Cardiovascular Center, 2-228 Shinbo, Fukui, 910-0833, Japan.
    Background: The long-term effects of some surgical treatment procedures of arch replacement for aortic dissection or aortic aneurysm are unknown.

    Case Presentation: The present study reports the case of a 68-year-old man admitted to our hospital for aortic arch anastomotic pseudoaneurysm with concomitant aortic root enlargement and coronary artery stenosis. Eleven years ago, at the age of 56 years, he underwent total arch replacement with island reconstruction for chronic aortic dissection. Read More

    Transcatheter aortic valve replacement in bicuspid aortic valve stenosis where do we stand?
    J Cardiovasc Surg (Torino) 2018 Jan 11. Epub 2018 Jan 11.
    Cedars-Sinai Heart Institute, Los Angeles, CA, USA -
    Bicuspid aortic valve is the most common congenital cardiac defect in adults, and symptom typically develops in adulthood. In the majority of cases, bicuspid aortic valve disease progress with ages and surgical aortic valve replacement is performed with excellent operative outcomes. However, with the relatively slow progression of disease, surgical aortic valve replacement is required in elderly patients but the surgical risk often deemed extremely high due to old age and multiple comorbidities. Read More

    Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
    Sci Rep 2018 Jan 12;8(1):595. Epub 2018 Jan 12.
    Research Center for Hypertension Management and Prevention in Community, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
    Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship. The stenosis of intracranial and extracranial arteries were evaluated in a total of 929 subjects through computerized tomographic angiography (CTA) from aortic arch to the skull base. Read More

    Frequency and Prognostic Significance of Acute Kidney Recovery in Patients Who Underwent Transcatheter Aortic Valve Implantation.
    Am J Cardiol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Medicine, Division of Cardiology, University of Vermont Larner College of Medicine, Burlington, Vermont.
    Acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) is associated with increased mortality. As significant hemodynamic improvement may occur with relief of aortic stenosis, we hypothesized that TAVI patients may demonstrate the opposite phenomena: acute kidney recovery (AKR). We studied the incidence and predictors of AKR in post-TAVI patients. Read More

    Effectiveness and Safety of Transcatheter Aortic Valve Implantation in Patients With Pure Aortic Regurgitation and Advanced Heart Failure.
    Am J Cardiol 2017 Dec 11. Epub 2017 Dec 11.
    Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy. Electronic address:
    Results of transcatheter aortic valve implantation (TAVI) for treatment of severe noncalcific isolated aortic regurgitation (AR) complicated by advanced heart failure or cardiogenic shock has been previously reported only in isolated case reports. Current self-expanding transcatheter aortic valves are designed to treat aortic valve stenosis, and have also been implanted in cases of severe AR due to degenerated bioprosthesis and in very few cases of native aortic valves. We report 13 consecutive inoperable patients with noncalcific, pure AR, and advanced heart failure treated with emergency percutaneous transfemoral implantation with self-expandable CoreValves at our institution between July 2012 and September 2017. Read More

    Myocardial Injury in Fetal Aortic Stenosis: Insights from Amniotic Fluid Analysis.
    Prenat Diagn 2018 Jan 11. Epub 2018 Jan 11.
    Boston Children's Hospital, Department of Obstetrics and Gynecology, Harvard Medical School, Boston, MA.
    Objective: Fetal aortic stenosis (AS) imposes pressure load on the developing left ventricle (LV) and leads to derangements in myocardial structure and function via mechanisms that are not well characterized.

    Methods: We compared amniotic fluid NT-BNP and troponin levels in fetuses with AS prior to fetal valvuloplasty and controls. We estimated correlations between NT-BNP and fetal echo parameters and identify NT-BNP cutoff associated with biventricular outcome RESULTS: Median NT-BNP level was higher in fetal AS than controls (3858 vs 1737 pg/ml, p<0. Read More

    Mid-term Outcome of 100 Consecutive Ross Procedures: Excellent Survival, But Yet to Be a Cure.
    Pediatr Cardiol 2018 Jan 12. Epub 2018 Jan 12.
    Pediatric Heart Centre, University Children's Hospital Zurich, Zurich, Switzerland.
    The Ross procedure offers excellent short-term outcome but the long-term durability is under debate. Reinterventions and follow-up of 100 consecutive patients undergoing Ross Procedure at our centre (1993-2011) were analysed. Follow-up was available for 96 patients (97%) with a median duration of 5. Read More

    Aorto-right Ventricular Fistula Following Percutaneous Transcatheter Aortic Valve Replacement: Case Report and Literature Review.
    Heart Views 2017 Oct-Dec;18(4):133-136
    Department of Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
    An 88-year-old woman with a prior history of aortic stenosis and history of valvuloplasty presented with worsening symptoms of heart failure and dizziness. She underwent successful transcatheter aortic valve replacement (TAVR) without complications. Follow-up echocardiograms revealed a small fistula connecting aorta to the right ventricle. Read More

    Preoperative Intra-Aortic Counterpulsation in Cardiac Surgery: Insights From a Retrospective Series of 588 Consecutive High-Risk Patients.
    J Cardiothorac Vasc Anesth 2017 Dec 6. Epub 2017 Dec 6.
    Cardio-Thoracic and Vascular Department, University Hospital of Trieste, Trieste, Italy.
    Objective: To support a rational use of preoperative intra-aortic balloon pump (IABP) in cardiac surgery.

    Design: Retrospective, observational study.

    Setting: Single university hospital. Read More

    NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis.
    J Am Coll Cardiol 2018 Jan;71(2):177-192
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
    Pathophysiological, epidemiological, and genetic studies provide strong evidence that lipoprotein(a) [Lp(a)] is a causal mediator of cardiovascular disease (CVD) and calcific aortic valve disease (CAVD). Specific therapies to address Lp(a)-mediated CVD and CAVD are in clinical development. Due to knowledge gaps, the National Heart, Lung, and Blood Institute organized a working group that identified challenges in fully understanding the role of Lp(a) in CVD/CAVD. Read More

    Systematic Review of the Cost-effectiveness of Transcatheter Interventions for Valvular Heart Disease.
    Eur Heart J Qual Care Clin Outcomes 2018 Jan 9. Epub 2018 Jan 9.
    Department of health services management, National School of Public health, Athens, Greece.
    Objectives: Transcatheter aortic valve implantation (TAVI) and transcatheter mitral valve repair (TMVR) are increasingly used for managing patients with valvular heart disease to whom surgery presents a high-risk. As these are costly procedures, a systematic review of studies concerned with their economic assessment was undertaken.

    Methods: The search was performed in PubMed and the Cochrane Library and followed recommended methodological steps. Read More

    Extracellular Vesicles As Mediators of Cardiovascular Calcification.
    Front Cardiovasc Med 2017 11;4:78. Epub 2017 Dec 11.
    Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Boston, MA, United States.
    Involvement of cell-derived extracellular particles, coined as matrix vesicles (MVs), in biological bone formation was introduced by Bonucci and Anderson in mid-1960s. In 1983, Anderson et al. observed similar structures in atherosclerotic lesion calcification using electron microscopy. Read More

    Acquired von Willebrand Syndrome Due to Aortic Valve Stenosis in a Case with Antiphospholipid Antibody.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Cardiovascular Surgery, Asahi General Hospital, Japan.
    Acquired von Willebrand syndrome (AVWS) is a bleeding disorder caused by an acquired deficiency of von Willebrand factor (vWF). Some patients with AVWS show a low bleeding tendency and are diagnosed by the presence of a mild prolongation of activated partial thromboplastin time (APTT) preoperatively. Another cause of APTT prolongation is the presence of antiphospholipid antibody (aPL). Read More

    Acute aortoiliac occlusive disease during percutaneous transluminal angioplasty in the setting of ST-elevation myocardial infarction: a case report.
    J Med Case Rep 2018 Jan 11;12(1). Epub 2018 Jan 11.
    Department of Cardiology, Wilson Regional Medical Center, United Health Services Hospitals, 30 Harrison St #250, Johnson City, NY, 13790, USA.
    Background: Aortoiliac occlusive disease, which is also referred to as Leriche syndrome, is a chronic atherosclerotic occlusive disease that occurs at the level of the aortic bifurcation. It is often thought to present with a triad of clinical symptoms: (1) intermittent lower extremity vascular claudication, (2) impotence, and (3) weak/absent femoral pulses.

    Case Presentation: We report a case of a 47-year-old Caucasian woman who presented with an acute inferior ST-elevation myocardial infarction. Read More

    Transcatheter aortic valve implantation operators - get involved in imaging!
    World J Cardiol 2017 Dec;9(12):853-857
    Heart Center Lucerne, Luzerner Kantonsspital, Lucerne 6000, Switzerland.
    Pre-procedural planning is the key element of transcatheter aortic valve implantation (TAVI). Multislice computed tomography of the chest, abdomen and pelvis with the ability to perform a 3-dimensional reconstruction has become the cornerstone of pre-procedural planning. We would like to encourage TAVI operators (interventional cardiologist and surgeons) to get involved in imaging. Read More

    Post-procedural N-terminal pro-brain natriuretic peptide predicts one-year mortality after transcatheter aortic valve implantation.
    Rev Port Cardiol 2018 Jan 6. Epub 2018 Jan 6.
    Cardiology Department, Santa Cruz Hospital, Carnaxide, Portugal.
    Introduction: Natriuretic peptides are ubiquitously used for diagnosis, follow-up and prognostic assessment in various heart conditions. N-terminal pro-brain natriuretic peptide (NT-proBNP) correlates with aortic stenosis severity, however its significance after transcatheter aortic valve implantation (TAVI) is not well established.

    Aim: We aimed to assess the prognostic value of NT-proBNP at one year in patients undergoing TAVI. Read More

    Improving the interoperability of biomedical ontologies with compound alignments.
    J Biomed Semantics 2018 Jan 9;9(1). Epub 2018 Jan 9.
    LaSIGE, Faculdade de Ciências, Universidade de Lisboa, Lisboa, 1749-016, Portugal.
    Background: Ontologies are commonly used to annotate and help process life sciences data. Although their original goal is to facilitate integration and interoperability among heterogeneous data sources, when these sources are annotated with distinct ontologies, bridging this gap can be challenging. In the last decade, ontology matching systems have been evolving and are now capable of producing high-quality mappings for life sciences ontologies, usually limited to the equivalence between two ontologies. Read More

    Colonic ischemia developed after laparoscopic colectomy for rectosigmoid cancer with focal infrarenal aortic stenosis.
    Asian J Endosc Surg 2018 Jan 8. Epub 2018 Jan 8.
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
    A 69-year-old woman with focal infrarenal aortic stenosis was diagnosed with rectosigmoid cancer. Because radical resection for colon cancer required dissection of vessels that supplied blood flow to the legs, revascularization by aortic stent placement was performed before the colectomy. We subsequently performed laparoscopic low anterior resection without any complications. Read More

    Computed tomography characteristics of the aortic valve and the geometry of SAPIEN 3 transcatheter heart valve in patients with bicuspid aortic valve disease.
    Eur Heart J Cardiovasc Imaging 2018 Jan 5. Epub 2018 Jan 5.
    Cedars-Sinai Medical Center, Heart Institute, 127 S.San Vincente Boulevard, Los Angeles, CA 90048, USA.
    Aims: We assessed the geometry of transcatheter heart valve (THV) and valve function associated with SAPIEN 3 implantation in patients with bicuspid aortic valve (BAV) stenosis.

    Methods And Results: We included 280 consecutive patients who had a contrast computed tomography (CT) before and after transcatheter aortic valve implantation (TAVI) in our institution. Each THV was assessed by CT at five cross-sectional levels: inflow, annulus, mid, sinus, and outflow. Read More

    Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve.
    Catheter Cardiovasc Interv 2018 Jan 4. Epub 2018 Jan 4.
    Monash Cardiovascular Research Centre, MonashHeart, Monash Medical Centre and Monash University, Melbourne, Australia.
    Objectives: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus™ valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality.

    Background: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. Read More

    Transubclavian approach: A competitive access for transcatheter aortic valve implantation as compared to transfemoral.
    Catheter Cardiovasc Interv 2018 Jan 3. Epub 2018 Jan 3.
    CIBER CV, Cardiology Department, Hospital Clínico Universitario, Valladolid, Spain.
    Aims: Empirically, transfemoral (TF) approach is the first choice for transcatheter aortic valve implantation (TAVI). We aimed to investigate whether transubclavian (TSc) and TF approaches present comparable major outcomes according to current evidence.

    Methods: We systematically searched PubMed, EMBASE, and Cochrane database for studies with symptomatic aortic stenosis patients who underwent TAVI through TF or TSc/axillary access from January/2006 to January/2017. Read More

    Clinical presentation, surgical management and outcomes of patients treated for aortic stenosis and coronary artery disease. Does age matter?
    Kardiol Pol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland, Długa 1/ 2, 61-848 Poznan, Poland.
    Background: Aortic stenosis and coronary artery disease (CAD) sharing similar risk factors are associated with aging of human population.

    Aim: The purpose of this study was to examine if age affects clinical presentation, intraoperative management and outcomes of patients that undergo simultaneous operations of aortic valve replacement (AVR) and coronary artery bypass grafting (CABG).

    Methods: The study involved 452 consecutive patients with the age of 64. Read More

    Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation - A Systematic Review.
    Circ J 2017 Dec 28. Epub 2017 Dec 28.
    CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute.
    Background: Transcatheter aortic valve implantation (TAVI) has become the standard of care for management of high-risk patients with aortic stenosis. Limited data is available regarding the performance of TAVI in patients with native aortic valve regurgitation (NAVR).Methods and Results:We performed a systematic review from 2002 to 2016. Read More

    Evaluation of Factors Associated With Achievement of Biventricular Repair After Bilateral Pulmonary Artery Banding in Patients With Interrupted Aortic Arch.
    World J Pediatr Congenit Heart Surg 2018 Jan;9(1):54-59
    3 Department of Cardiovascular Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
    Background: At our institution, we perform bilateral pulmonary artery banding (BPAB) as the first-stage palliation for interrupted aortic arch (IAA) with low birth weight or severe subaortic stenosis (SAS). The present study aimed to identify factors that may influence the decision regarding the type of second-stage operation, that is, univentricular palliation or biventricular repair, in these patients.

    Methods: Cardiac catheterization and angiographic data of nine patients with IAA who underwent initial BPAB and subsequent univentricular or biventricular repair were retrospectively analyzed. Read More

    The safety of concomitant transcatheter aortic valve replacement and percutaneous coronary intervention: A systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Dec;96(48):e8919
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Background: TAVR is a rapidly spreading treatment option for severe aortic valve stenosis. Significant coronary artery disease (CAD) is present in 40% to 75% of patients undergoing TAVR. However, when to treat the concomitant coronary artery lesions is controversial. Read More

    Genetic polymorphism of angiotensin-converting enzyme and hypertrophic cardiomyopathy risk: A systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Dec;96(48):e8639
    Department of Pediatrics, the First Hospital of Jilin University, Changchun, Jilin, China.
    Background: Genetic factors in the pathogenesis of cardiomyopathies have received a lot of attention during the past 2 decades. Some studies have reported that angiotensin-converting enzyme (ACE) gene has been associated with hypertrophic cardiomyopathy (HCM). However, there have been inconsonant results among different studies. Read More

    Two-stage hybrid treatment strategy for an adult patient with aortic arch coarctation, poststenotic aneurysm, and hypoplastic left subclavian artery: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8618
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Rationale: Coarctation of aorta in adulthood is usually complicated by other cardiovascular anomalies, posing great technical challenge for intervention.

    Patient Concerns: Here, we report an extremely rare case of aortic arch coarctation combined with a poststenotic biloculated calcified aneurysm and hypoplastic left subclavian artery.

    Interventions: First, an extra-anatomic bypass was established, along with narrowing of aorta just proximal and distal to the aneurysm. Read More

    Cellular Mechanisms of Aortic Valve Calcification.
    Bull Exp Biol Med 2018 Jan 8;164(3):371-375. Epub 2018 Jan 8.
    V. A. Almazov National Medical Research Center, St. Petersburg, Russia.
    Comparative in vitro study examined the osteogenic potential of interstitial cells of aortic valve obtained from the patients with aortic stenosis and from control recipients of orthotopic heart transplantation with intact aortic valve. The osteogenic inductors augmented mineralization of aortic valve interstitial cells (AVIC) in patients with aortic stenosis in comparison with the control level. Native AVIC culture of aortic stenosis patients demonstrated overexpression of osteopontin gene (OPN) and underexpression of osteoprotegerin gene (OPG) in comparison with control levels. Read More

    Multidetector computed tomography sizing of aortic annulus prior to transcatheter aortic valve replacement (TAVR): Variability and impact of observer experience.
    Diagn Interv Imaging 2018 Jan 4. Epub 2018 Jan 4.
    Department of Radiology, Cardiac MR/CT Unit, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, France; Department of Cardiology, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex, France. Electronic address:
    Purpose: To evaluate intra- and inter-observer variability of multidetector computed tomography (MDCT) sizing of the aortic annulus before transcatheter aortic valve replacement (TAVR) and the effect of observer experience, aortic valve calcification and image quality.

    Methods: MDCT examinations of 52 consecutive patients with tricuspid aortic valve (30 women, 22 men) with a mean age of 83±7 (SD) years (range: 64-93 years) were evaluated retrospectively. The maximum and minimum diameters, area and circumference of the aortic annulus were measured twice at diastole and systole with a standardized approach by three independent observers with different levels of experience (expert [observer 1]; resident with intensive 6 months practice [observer 2]; trained resident with starting experience [observer 3]). Read More

    Calculation of Mitral Valve Area in Mitral Stenosis: Comparison of Continuity Equation and Pressure Half Time With Two-Dimensional Planimetry in Patients With and Without Associated Aortic or Mitral Regurgitation or Atrial Fibrillation.
    Acta Med Iran 2017 Nov;55(11):696-704
    Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Accurate measurement of Mitral Valve Area (MVA) is essential to determining the Mitral Stenosis (MS) severity and to achieving the best management strategies for this disease. The goal of the present study is to compare mitral valve area (MVA) measurement by Continuity Equation (CE) and Pressure Half-Time (PHT) methods with that of 2D-Planimetry (PL) in patients with moderate to severe mitral stenosis (MS). This comparison also was performed in subgroups of patients with significant Aortic Insufficiency (AI), Mitral Regurgitation (MR) and Atrial Fibrillation (AF). Read More

    Clinical Significance of Ejection Dynamics Parameters in Patients with Aortic Stenosis: An Outcome Study.
    J Am Soc Echocardiogr 2018 Jan 3. Epub 2018 Jan 3.
    GCS-Groupement des Hôpitaux de l'Institut Catholique de Lille, Cardiology Department and Heart Valve Center, Faculté Libre de Médecine/Université Catholique de Lille, and Centre Hospitalier Régional Universitaire de Lille, Service de Chirurgie Cardiaque, Lille; INSERM U 1088, Université de Picardie. Electronic address:
    Background: Ejection dynamics parameters are useful in assessing prosthetic valve obstruction, but very limited data are available in the setting of native aortic stenosis (AS). The aim of this study was to evaluate and compare the prognostic value of acceleration time (AT) and the ratio of AT to ejection time (ET) in patients with AS.

    Methods: AT and AT/ET were prospectively measured in 456 patients with AS (aortic valve area < 1. Read More

    Antithrombotic Treatment after Transcatheter Heart Valves Implant.
    Semin Thromb Hemost 2018 Jan 5. Epub 2018 Jan 5.
    The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
    Transcatheter heart valve replacement technology was introduced as alternative to surgery for the growing high-risk profile population. Developed first, aortic valve replacement (TAVR) became a standard of care for patients with severe aortic stenosis at high operative risk, with a potential future use also for low-risk subjects. In the last decade, a multitude of transcatheter mitral valve replacement (TMVR) devices have been developed for the treatment of severe mitral regurgitation, with encouraging results coming from first-in-man and feasibility studies. Read More

    Use of Impella 5.0 Prior to Transcatheter Aortic Valve Replacement in a Patient with Severe Aortic Stenosis and Cardiogenic Shock.
    J Heart Valve Dis 2017 Jul;26(4):485-487
    Texas A&M Health Science Center College of Medicine/Scott and White Medical Center, Temple, TX, USA.
    The use of transcatheter aortic valve replacement (TAVR) has risen dramatically during the past decade. Notably, the procedure can reduce symptoms and improve prognosis in patients who would otherwise be excluded from intervention due to prohibitive surgical risk. During the same time period, the use of percutaneous mechanical circulatory support devices for patients with severe left ventricular dysfunction, including the Impella System (Abiomed, Inc. Read More

    Simultaneous Transcatheter Intervention for Coarctation of the Aorta and Bicuspid Aortic Valve.
    J Heart Valve Dis 2017 Jul;26(4):481-484
    Department of Cardiac Surgery, Sendai Konsei Hospital, Sendai, Japan.
    Coarctation of the aorta (CoA) is a relatively common congenital heart anomaly, and bicuspid aortic valve (BAV) is a common congenital heart disease that coexists with CoA. In larger children and adults with CoA, transcatheter intervention has gained acceptance, but for surgical high-risk patients with aortic stenosis, the use of transcatheter aortic valve implantation (TAVI) has been established. Recently, although favorable data have been reported for TAVI when treating BAV, simultaneous transcatheter intervention for CoA and BAV will prove to be a challenge because of the unique anatomy involved requires multiple procedural steps and also has problems of site access. Read More

    Pathophysiological Factors Associated with Left Ventricular Perforation in Transcatheter Aortic Valve Implantation by Transfemoral Approach.
    J Heart Valve Dis 2017 Jul;26(4):430-436
    Department of Cardiac Surgery, Central Hospital Bad Berka, Bad Berka, Germany.
    Background: Left ventricular (LV) perforation is one of the rare and most serious complications of transcatheter aortic valve implantation (TAVI). The study aim was to determine the pathophysiological factors associated with this serious complication.

    Methods: A retrospective study was conducted of pathophysiological factors shown in echocardiograms and computed tomography angiograms performed preoperatively in patients who developed LV perforation during transfemoral TAVI (study group) with regards to anatomic and functional variables. Read More

    Determinants and Outcome of Decision Making Among Patients with Severe Aortic Stenosis.
    J Heart Valve Dis 2017 Jul;26(4):413-422
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway.
    Background: Aortic valve replacement (AVR) improves survival and quality of life in patients with severe aortic stenosis (AS), but despite clear indications for surgical treatment a significant proportion of patients do not undergo AVR. The study aim was to identify clinical variables associated with the decision to perform AVR, and to assess the prognostic effect of surgery versus medical treatment in patients with severe AS adjusted for significant confounders and effect modifiers.

    Methods: A prospective observational study of consenting patients aged >18 years who were under consideration for AVR at the authors' tertiary teaching hospital was conducted. Read More

    Radiofrequency catheter ablation of atrioventricular nodal reentry tachycardia in children and adolescents: a single center experience.
    Korean J Pediatr 2017 Dec 22;60(12):390-394. Epub 2017 Dec 22.
    Department of Pediatrics, Kyungpook National University Hospital, Daegu, Korea.
    Purpose: Atrioventricular nodal reentry tachycardia (AVNRT) is less common in pediatric patients than in adult patients. Thus, data for pediatric AVNRT patients are insufficient. Hence, we aimed to analyze the patient characteristics, treatment, and any recurrences in pediatric AVNRT patients. Read More

    The effect of demographic features on aortic arch anatomy and its role in the etiology of cerebrovascular disease.
    Neuropsychiatr Dis Treat 2018 20;14:29-35. Epub 2017 Dec 20.
    Department of Neurology, Faculty of Medicine, Harran University, Harran, Turkey.
    Purpose: The aim of this study was to retrospectively evaluate the distribution of aortic arches, the relationship with demographic characteristics, and the results of carotid and vertebral artery stenting procedures in patients diagnosed with cerebrovascular disease through the intra-arterial digital subtraction angiography (DSA) technique.

    Methods: A retrospective examination was performed on 288 patients diagnosed with cerebrovascular disease, who underwent DSA in the Department of Neurology of Gaziantep University Medical Faculty and Kahramanmaraş¸ Sütçü Imam University Medical Faculty. The patients were examined in respect of demographic features and aortic arch anatomic structure characteristics. Read More

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