57,554 results match your criteria Aortic Stenosis


Cardiac Damage Staging in Aortic Stenosis: A Perspective From the Cardiac Catheterization Laboratory.

Can J Cardiol 2020 Mar 30. Epub 2020 Mar 30.

Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval/Québec Heart & Lung Institute-Laval University, Québec City, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2020.03.033DOI Listing

[Cardiac scintigraphy-centered diagnostic process in transthyretin cardiac amyloidosis].

Turk Kardiyol Dern Ars 2020 Jul;48(5):514-521

Department of Cardiology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.

Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy. Amyloid fibrils in the form of misfolded endogenous proteins accumulate in the heart, as well as the kidneys, liver, and gastrointestinal tract. The most common forms of CA are transthyretin (TTR) and immunoglobulin light chain amyloidosis (AL). Read More

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http://dx.doi.org/10.5543/tkda.2020.90914DOI Listing

Bioprosthetic valve oversizing is associated with increased risk of valve thrombosis following TAVR.

Catheter Cardiovasc Interv 2020 Jul 6. Epub 2020 Jul 6.

Division of Cardiovascular Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.

Background: Hypoattenuating leaflet thickening (HALT), the radiographic manifestation of transcatheter heart valve thrombosis, is commonly identified following transcatheter aortic valve replacement (TAVR) and associated with increased risk of stroke and structural valve deterioration. While anticoagulation effectively resolves HALT, routine use remains controversial. We aimed to identify hemodynamic, anatomic, and comorbid predictors of HALT. Read More

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http://dx.doi.org/10.1002/ccd.29104DOI Listing

Antithrombotic treatment in patients with stroke and supracardiac atherosclerosis.

Neurology 2020 Jul 6. Epub 2020 Jul 6.

From the Department of Internal Medicine (D.S., I.L., K.M., G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece; School of Biomedical Engineering and Imaging Sciences (G.G.), King's College, London, UK; Department of Biostatistics and Research Support (K.P.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands; biostatistics consultant (L.A.P.), Minot, ND; Department of Clinical Therapeutics (E.K., K.V.), Alexandra Hospital, University of Athens, Greece; Imperial College London (E.K.), UK; and Department of Internal Medicine, School of Medicine (H.M.), University of Ioannina, Greece.

Objective: To compare the efficacy and safety of oral anticoagulants vs antiplatelets in patients with stroke and atherosclerotic plaques in the aortic arch or cervical or intracranial arteries, collectively described as supracardiac atherosclerosis.

Methods: We searched PubMed and Scopus until August 28, 2019, for randomized trials comparing oral anticoagulants vs antiplatelets in patients with stroke and supracardiac atherosclerosis using the terms "anticoagulant or anticoagulation" and "antiplatelet or aspirin" and "randomized controlled trial or RCT" and "stroke or cerebral ischemia" and "aortic or carotid or vertebrobasilar or intracranial or atherosclerosis or stenosis or arterial." Four outcomes were assessed: recurrent ischemic stroke, major ischemic event or death, major bleeding, and intracranial bleeding. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009823DOI Listing

Impaired Fibrinolysis in Patients with Isolated Aortic Stenosis is Associated with Enhanced Oxidative Stress.

J Clin Med 2020 Jun 25;9(6). Epub 2020 Jun 25.

Institute of Cardiology, Jagiellonian University Medical College, 31-202 Krakow, Poland.

Aortic stenosis (AS) has been associated with impaired fibrinolysis and increased oxidative stress. This study aimed to investigate whether oxidative stress could alter fibrin clot properties in AS. We studied 173 non-diabetic patients, aged 51-79 years, with isolated AS. Read More

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http://dx.doi.org/10.3390/jcm9062002DOI Listing

Emergency treatment of acute decompensated critical aortic stenosis with transcatheter aortic valve implantation.

Future Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiothoracic Surgery, Gold Coast University Hospital, 1 Hospital Blvd, Southport, QLD 4215, Australia.

Transcatheter aortic valve implantation (TAVI) is relatively contraindicated in the bicuspid aortic valve, and to our knowledge has not been tried where the true native annulus is of a size far in excess of current device capabilities. We present here a case of a successful emergency TAVI of a 73-year-old previously healthy man, who presented with cardiogenic shock, ventricular tachycardia storm and severe left ventricular dysfunction because of the underlying critical bicuspid aortic stenosis with aortic annulus area of 991.9 mm and associated moderate aortic incompetence (the Society of Thoracic Surgeons (STS) risk score; score mortality of 40. Read More

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http://dx.doi.org/10.2217/fca-2020-0092DOI Listing

Myval transcatheter heart valve system in the treatment of severe symptomatic aortic stenosis.

Future Cardiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Cardiology, Apollo Hospital Enterprise Limited, Chennai, Tamil Nadu 600006, India.

The transcatheter aortic valve replacement (TAVR) is an established treatment for patients with severe symptomatic aortic stenosis (AS) at prohibitive risk for surgery. It is an alternative treatment to surgical aortic valve replacement in patients with AS at intermediate- and high-surgical risk. Although regulatory authorities extend the indications of TAVR to treat patients at low-surgical risk, the limitations of earlier-generation transcatheter heart valve (THV) systems accelerate the development of improved newer generation of THV systems. Read More

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http://dx.doi.org/10.2217/fca-2020-0020DOI Listing

Transcatheter aortic valve implantation (TAVI) in cardiogenic shock: TAVI-shock registry results.

Catheter Cardiovasc Interv 2020 Jul 6. Epub 2020 Jul 6.

Interventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Objectives: Aim of this study is to evaluate safety, feasibility, and mid-term outcome of transcatheter aortic valve implantation (TAVI) in cardiogenic shock (CS).

Background: Balloon aortic valvuloplasty in patients with severe aortic valve stenosis (SAS) complicated by CS is indicated but associated with a grim prognosis. TAVI might be a more reasonable treatment option in this setting but data are scant. Read More

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http://dx.doi.org/10.1002/ccd.29112DOI Listing

Mendelian randomization of plasma lipids and aortic valve stenosis: the importance of outlier variants and population stratification.

Eur Heart J 2020 Jul 6. Epub 2020 Jul 6.

Deep Medicine, Oxford Martin School, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/eurheartj/ehaa476DOI Listing

The midterm results of thoracic endovascular aortic repair with a precurved fenestrated endograft in zone 0-1.

Eur J Cardiothorac Surg 2020 Jul 5. Epub 2020 Jul 5.

Department of Cardiovascular Surgery, Tokyo Women's Medical University, The Heart Institute of Japan, Shinjukuku, Tokyo, Japan.

Objectives: Thoracic endovascular aortic repair (TEVAR) for the treatment of aortic arch disease remains challenging due to certain anatomical and haemodynamic features. The purpose of this study was to evaluate the midterm results of TEVAR with a second-generation fenestrated endograft for aortic arch disease.

Methods: This non-randomized, interventional study was part of a multicentre clinical trial conducted between 2010 and 2011 and was designed to assess the effectiveness of a second-generation precurved fenestrated endograft for aortic arch disease. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa165DOI Listing

Lp(a) and Calcific Aortic Valve Stenosis: Direct LPA Targeting or PCSK9-Lowering Therapy?

Trends Cardiovasc Med 2020 Jul 2. Epub 2020 Jul 2.

Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.

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http://dx.doi.org/10.1016/j.tcm.2020.06.009DOI Listing

Effectiveness and Safety of the ACURATE Neo Prosthesis in 1,000 Patients With Aortic Stenosis.

Am J Cardiol 2020 Jun 7. Epub 2020 Jun 7.

Kerckhoff Heart Center, Department of Cardiology, Bad Nauheim, Germany; Department of Cardiology, Justus-Liebig University of Giessen, Giessen, Germany.

The ACURATE neo transcatheter heart valve has demonstrated a balanced profile with low rates of permanent pacemaker implantation, low risk of coronary obstruction, and favorable hemodynamic properties whilst having an acceptable rate of ≥moderate paravalvular leakage (PVL). Here, we report in-hospital results and assess the learning curve for implantation of the ACURATE neo device in a large, single-center cohort. The cohort of this retrospective, observational study comprised 1,000 consecutive patients with severe aortic stenosis who underwent transfemoral transcatheter aortic valve implantation using the ACURATE neo prosthesis between May 2012 and December 2019. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.05.044DOI Listing

Risk Factors of Cerebellar Microembolic Infarctions Following Carotid Artery Stenting.

World Neurosurg 2020 Jul 1. Epub 2020 Jul 1.

Department of Neurosurgery, St. Marianna University School of Medicine.

This study analyzes the incidence of microembolic infarctions (MIs) in the cerebellum following carotid artery stenting (CAS) to determine the risk factors. From 2012 to 2019, 162 CASs in 155 patients were performed at our hospital. Fifty-seven (35. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.207DOI Listing

Impact of aortic annulus enlargement on the outcomes of aortic valve replacement: a meta-analysis.

Semin Thorac Cardiovasc Surg 2020 Jul 1. Epub 2020 Jul 1.

Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco - PROCAPE, Recife, Brazil; University of Pernambuco - UPE, Recife, Brazil; Nucleus of Postgraduate and Research in Health Sciences of Faculty of Medical Sciences and Biological Sciences Instituite - FCM/ICB, Recife, Brazil.

We sought to evaluate the impact of surgical aortic annulus enlargement (ARE) on the perioperative outcomes of surgical aortic valve replacement (SAVR). Databases were searched for for articles published by October 2019 in order to carry out a systematic review followed by meta-analysis. Thirteen studies with 40,447 patients (AVR with AAE: 4,686 patients; AVR without AAE: 35,761 patients) were included. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.046DOI Listing

Corrected QT interval in Severe Aortic Stenosis: Clinical and Hemodynamic Correlates and Prognostic Impact.

Am J Med 2020 Jul 1. Epub 2020 Jul 1.

Cardiology Division, Kantonsspital St. Gallen, Switzerland. Electronic address:

Background: The role of the ECG for risk stratification in patients with severe aortic stenosis is not established. We assessed the hemodynamic correlates and the prognostic value of the corrected QT interval (QTc) in patients with severe AS undergoing aortic valve replacement.

Methods: The QT interval was measured in a 12-lead ECG in 485 patients (age 74±10 years, 57% males) with severe aortic stenosis [indexed aortic valve area 0. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.05.035DOI Listing

Spontaneous thrombosis of a transcatheter aortic valve replacement-induced aortic root pseudoaneurysm.

Catheter Cardiovasc Interv 2020 Jul 4. Epub 2020 Jul 4.

The Heart Center - Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Aortic annulus rupture or aortic root perforation is a rare complication of transcatheter aortic valve replacement (TAVR), requiring emergent cardiac surgery and carrying a high intraoperative mortality. Few cases can be managed conservatively, provided a strict clinical follow-up. This study describes the case of a 78-year-old patient with a degenerated bicuspid aortic valve stenosis who presented with a late aortic root perforation following TAVR, which was successfully managed applying a "watchful waiting" approach. Read More

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http://dx.doi.org/10.1002/ccd.29108DOI Listing

Fetal aortic valvuloplasty may rescue fetuses with critical aortic stenosis and hydrops.

Ultrasound Obstet Gynecol 2020 Jul 4. Epub 2020 Jul 4.

Children's Heart Center Linz, Department of Paediatric Cardiology, Kepler University Hospital, Medical Faculty of the Johannes Kepler University, Linz, Austria.

Objectives: Critical aortic stenosis (CAS) with a restrictive interatrial septum may lead to fetal congestive heart failure and hydrops, usually leading to fetal demise if left untreated. The aim of this study was to assess the effects of fetal aortic valvuloplasty on hemodynamics and outcome in these patients.

Methods: A retrospective review for fetuses with CAS and signs of hydrops undergoing fetal aortic valvuloplasty (FAV) in our center since 2000 was performed. Read More

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http://dx.doi.org/10.1002/uog.22138DOI Listing

Potential impact of dynamic automated CT aortic annular measurements on outcomes for transcatheter aortic valve replacement sizing.

Int J Cardiovasc Imaging 2020 Jul 3. Epub 2020 Jul 3.

Division of Cardiology, Department of Medicine, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, NY, USA.

To determine the potential impact of automated computed tomography (CT) software used for aortic annular sizing for transcatheter aortic valve replacement (TAVR) on paravalvular leak (PVL) and major adverse cardiovascular events (MACE) as compared to standard CT manual measurement. In 60 TAVR patients (84 ± 7 years, 60% male), we evaluated the preprocedural CT scans. For the standard manual measurement, we measured the perimeter and area from a single cardiac phase deemed to be of maximum systolic opening. Read More

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http://dx.doi.org/10.1007/s10554-020-01928-zDOI Listing

The Effects of Transcatheter Aortic Valve Replacement on Mitral Valve Function.

Cardiol Rev 2020 Jun 18. Epub 2020 Jun 18.

Department of Medicine New York Medical College/Westchester Medical Center, Valhalla, NY 10595.

The transcatheter aortic valve replacement (TAVR) procedure provides a way to treat severe aortic stenosis in the large population of patients who are not candidates for surgical aortic valve replacement (SAVR). Mitral regurgitation is often concomitant to aortic stenosis in these patients due to the high pressure of the left ventricle and long-term damage to the mitral valve. Due to the proximity of the aortic valve to the mitral valve, TAVR can impact the functional status of the mitral valve by affecting left ventricular outlet obstruction and the mitral valve annular shape. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000315DOI Listing

Atrial pacing and administration of nifekalant hydrochloride for unstable atrial fibrillation: a case report.

Eur Heart J Case Rep 2020 Jun 14;4(3):1-5. Epub 2020 May 14.

Department of Cardiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, Fukuoka 810-8563, Japan.

Background: Atrial fibrillation (AF) is a common arrhythmia in patients with hypertrophic cardiomyopathy (HCM) and can deteriorate haemodynamic status.

Case Summary: We report a case of a 77-year-old woman with cardiogenic shock due to paroxysmal AF, complicated with HCM and aortic stenosis. Atrial fibrillation was successfully managed with temporary atrial pacing and administration of nifekalant hydrochloride without invasive mechanical circulatory support until surgery. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319856PMC

Aortic root rupture during balloon-expandable transcatheter aortic valve replacement in a patient without recognized risk factors for aortic root rupture: a case report.

Eur Heart J Case Rep 2020 Jun 26;4(3):1-4. Epub 2020 May 26.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan.

Background: Aortic root rupture is a severe complication of balloon-expandable transcatheter aortic valve replacement (TAVR). Although previous studies have revealed several risk factors for this complication, predicting this complication is occasionally difficult.

Case Summary: A 78-year-old male patient underwent TAVR via a transfemoral approach using a 29-mm balloon-expandable valve. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319835PMC

Aortic stenosis of a bicuspid aortic valve in a patient with Klippel-Feil syndrome: a case report.

Eur Heart J Case Rep 2020 Jun 24;4(3):1-4. Epub 2020 Mar 24.

Department of Cardiothoracic Surgery, Barts Heart Centre, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.

Background: Klippel-Feil syndrome (KFS) is a rare congenital anomaly of the cervical spine, which is associated with a number of cardiovascular malformations, including coarctation of the aorta, bicuspid aortic valve (BAoV), and aortic aneurysm. Operative management of aortic stenosis of a BAoV in a patient with KFS has not been previously reported.

Case Summary: A 54-year-old Caucasian woman with known KFS presented to her local hospital for elective cholecystectomy. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319826PMC

A case report of a coronary myocardial bridge with impaired full-cycle ratio during dobutamine challenge.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Division of Cardiology, Department of Medicine, New York-Presbyterian Hospital/Columbia University Irving Medical Center, 161 Fort Washington Ave, New York, NY 10032, USA.

Background: A myocardial bridge (MB) is a coronary variant in which an epicardial coronary artery tunnels through the myocardial band. Although MBs have been reported to cause ischaemia, physiological assessment of an MB has not been fully established.

Case Summary: We encountered a case with exertional chest pain who underwent coronary angiography showing an MB at the mid-left anterior descending artery with systolic compression. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319821PMC

'Minimalist approach' for transcatheter mitral valve replacement using intracardiac echocardiography and conscious sedation: a case series.

Eur Heart J Case Rep 2020 Jun 24;4(3):1-5. Epub 2020 Apr 24.

Department of Cardiology, Heart & Vascular Institute, Cleveland Clinic Florida, 2590 Cleveland Clinic Blvd, Weston, FL 33331, USA.

Background: Transcatheter aortic valve implantation operators have adapted to a less invasive technique by foregoing the use of general anaesthesia and transoesophageal echocardiography. This is known as a 'minimalist approach'. This approach has yet to be explored in transcatheter mitral valve replacement (TMVR). Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319820PMC

Mechanical tricuspid balloon 'valvuloplasty' in a prohibitive risk patient with cardiogenic shock: a case report.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-4. Epub 2020 May 3.

Cleveland Clinic Florida, 2590 Cleveland Clinic Boulevard, Desk 23/24, Weston, FL 33331, USA.

Background: We present a complex case of a failing tricuspid mechanical valve prosthesis in a patient with refractory cardiogenic shock at prohibitive risk for surgery in whom balloon 'valvuloplasty' resulted in immediate haemodynamic improvement in valve function.

Case Summary: A 67-year-old woman with remote history of endocarditis s/p tricuspid valve repair and mechanical aortic valve replacement was referred for second opinion and management of new severe symptomatic tricuspid valve stenosis resulting in progressive debilitating congestive heart failure (HF). The patient was approved by the heart team to undergo redo open heart for surgical repair of the tricuspid valve. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319815PMC

Transverse Pericardial Sinus Hematoma From Type A Aortic Dissection: A Diagnostic Challenge.

Cureus 2020 May 27;12(5):e8322. Epub 2020 May 27.

Division of Cardiovascular Disease, Saint Luke's Mid America Heart Institute, Kansas City, USA.

Ascending (type A) aortic dissection can rarely result in contained transverse pericardial sinus hematoma that compresses adjacent structures making diagnosis more challenging. We present a rare case of a 77-year-old man who presented with sudden-onset chest pain and was admitted for a presumed acute coronary syndrome. Coronary angiography did not show significant stenosis and ruled out acute coronary syndrome. Read More

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http://dx.doi.org/10.7759/cureus.8322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325413PMC

Early and Intermediate-Term Outcome of Balloon Aortic Valvuloplasty in Children With Aortic Stenosis and Left Ventricular Dysfunction at Tertiary Care Hospital.

Cureus 2020 May 27;12(5):e8321. Epub 2020 May 27.

Paediatric Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.

Background Left ventricular (LV) dysfunction in patients with aortic valve stenosis (AVS) is seen in two scenarios: in neonates and in elderly patients. Neonatal AVS may present as a congestive cardiac failure (CCF), while older children rarely present with CCF if they have not been diagnosed early. Only a few reports of LV dysfunction with AVS have been described in the literature. Read More

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http://dx.doi.org/10.7759/cureus.8321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325342PMC

Aortic uncrossing and tracheobronchopexy corrects tracheal compression and tracheobronchomalacia associated with circumflex aortic arch.

J Thorac Cardiovasc Surg 2020 May 6. Epub 2020 May 6.

Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

Objective: Aortic uncrossing is an effective procedure for relieving the external airway compression from a circumflex aortic arch by transferring the aortic arch to the same side as the descending aorta. However, patients frequently have residual tracheobronchomalacia (TBM), which may result in persistent postoperative symptoms. We review a series of patients who underwent an aortic uncrossing and concomitant tracheobronchopexy to correct the airway compression and residual TBM. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.03.158DOI Listing

Cardiac sympathetic dysfunction in left ventricular hypertrophy caused by arterial hypertension and degenerative aortic stenosis.

J Nucl Cardiol 2020 Jul 1. Epub 2020 Jul 1.

Cardiac, Thoracic and Vascular Department, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Background: To evaluate cardiac sympathetic innervation in hypertensive patients with left ventricular (LV) hypertrophy (H) and aortic stenosis (AS) submitted to transcatheter aortic valve implantation (TAVI).

Methods And Results: Twenty-two hypertensive elders (82 ± 5 years) with severe AS and significant LVH (> 122 g·m in women and > 149 g·m in men) were compared with 14 patients with uncomplicated essential hypertension (HT) with similar degree of LVH and 10 controls. I-metaiodobenzylguanidine (MIBG) and Tc-tetrofosmin SPECT acquisitions were obtained to assess sympathetic innervation and LV perfusion. Read More

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http://dx.doi.org/10.1007/s12350-020-02250-wDOI Listing

Surgical Aortic Valve Replacement for Aortic Stenosis in Dialysis Patients - Analysis of Japan Cardiovascular Surgery Database.

Circ J 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiovascular Surgery, Toho University, Sakura Medical Center.

Background: Perioperative risk during surgical aortic valve replacement (SAVR) is reportedly high in dialysis patients. We aimed to determine the postoperative mortality and morbidity and identify the perioperative risk factors of mortality during SAVR in dialysis-dependent patients.Methods and Results:From the Japan Adult Cardiovascular Surgery Database, we compared 2,875 dialysis-dependent patients with 18,839 non-dialysis patients who all underwent SAVR between January 2013 and December 2016. Read More

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http://dx.doi.org/10.1253/circj.CJ-20-0042DOI Listing

TAVR in a 65-Year-Old Man With a Bicuspid Aortic Valve With Extremely Large Annulus and Severe Left Ventricular Dysfunction.

J Invasive Cardiol 2020 Jul;32(7):E199

Transcatheter Aortic Valve Replacement Program, Stony Brook University Medical Center, Health Sciences Center T16-080, Stony Brook, NY 11794-8160 USA.

This case illustrates that transfemoral transcatheter aortic valve replacement is safe and feasible in patients with bicuspid aortic stenosis with extremely large annulus and concomitant severe left ventricular dysfunction. Read More

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"Avulsion Injury" of the Artery by a Suture-Mediated Closure System During Transcatheter Aortic Valve Implantation.

J Invasive Cardiol 2020 Jul;32(7):E193

Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Japan.

We describe a cut-down method that is useful in cases with calcification restricted to the region surrounding the puncture site in transcatheter aortic valve implantation patients with severe aortic stenosis. Read More

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Neighborhood socioeconomic status and aortic stenosis: A Swedish study based on nationwide registries and an echocardiographic screening cohort.

Int J Cardiol 2020 Jun 28. Epub 2020 Jun 28.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Background: Aortic stenosis (AS) is the most common valvular heart disease in developed countries, confers high mortality in advanced cases, but can effectively be reversed using endovascular or open-heart surgery. We evaluated the association between AS and neighborhood socioeconomic status (NSES).

Methods: We used Swedish population-based nationwide registers and an echocardiography screening cohort during the study period 1997-2014. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.034DOI Listing

Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis. Reply.

N Engl J Med 2020 07;383(1):92-93

Samsung Medical Center, Seoul, South Korea.

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http://dx.doi.org/10.1056/NEJMc2016167DOI Listing

Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis.

N Engl J Med 2020 07;383(1):92

Munson Medical Center, Traverse City, MI.

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http://dx.doi.org/10.1056/NEJMc2016167DOI Listing

Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis.

N Engl J Med 2020 07;383(1):91-92

University of California, San Francisco, San Francisco, CA

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http://dx.doi.org/10.1056/NEJMc2016167DOI Listing

3D transesophageal echocardiography in TAVR.

Echocardiography 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology, Kings College Hospital, London, UK.

Recently, there has been an increasingly minimalistic approach to transcatheter aortic valve replacement (TAVR), with most procedures now performed under conscious sedation without real time transesophageal echocardiography (TEE) guidance. Proponents of echo should not feel discouraged by this; it is the initial insights that were gained with procedural TEE during the early years of TAVR that have allowed the procedure's gradual maturation and sophistication. Experienced centers that have promoted extensive TAVR TEE programs continue to maximize the benefits of echocardiography in both procedural planning and execution. Read More

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http://dx.doi.org/10.1111/echo.14777DOI Listing

Assessing causality in associations of lipid levels with aortic valve stenosis.

Eur Heart J 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

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http://dx.doi.org/10.1093/eurheartj/ehaa371DOI Listing

Bone Morphogenetic Protein-2 and Osteopontin Gene Expression in Epicardial Adipose Tissue from Patients with Coronary Artery Disease Is Associated with the Presence of Calcified Atherosclerotic Plaques.

Diabetes Metab Syndr Obes 2020 11;13:1943-1951. Epub 2020 Jun 11.

Molecular Biology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.

Purpose: It has been proposed that the cardiovascular effects of obesity are related to epicardial adipose tissue (EAT), which seems to play an active role on the development and calcification of atherosclerotic plaques, but the mechanisms are still unknown. Therefore, the aim of this study was to determine whether the EAT expresses the genes of calcifying factors and whether such expression is associated with the body mass index (BMI) and with the presence of coronary artery calcium (CAC) in patients with coronary artery disease (CAD).

Patients And Methods: Forty-three patients with CAD were enrolled specifically for this study, and their CAC score and EAT volume were determined by computed tomography. Read More

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http://dx.doi.org/10.2147/DMSO.S253632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295210PMC

An unusual presentation of developmental anomalies of the cardiovascular system including tetralogy of fallot, double outlet right ventricle, patent foramen ovale and persistent right aortic arch in a Friesian calf.

BMC Vet Res 2020 Jun 30;16(1):224. Epub 2020 Jun 30.

Section of Herd Health and Animal Husbandry, School of Veterinary Medicine, Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Congenital heart diseases are occasionally encountered in the bovine species. Ventricular septal defects (VSD) and atrial septal defects (ASD) are reported to be the most common; however, a vast collection have been reported [1, 2]. Congenital heart diseases is thought to represent less than 3% of all congenital abnormalities in calves [3]. Read More

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http://dx.doi.org/10.1186/s12917-020-02439-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325375PMC

Aortic valve: anatomy and structure and the role of vasculature in the degenerative process.

Acta Cardiol 2020 Jun 30:1-14. Epub 2020 Jun 30.

First Department of Cardiology, 'Hippokration' Hospital, Medical School, University of Athens, Athens, Greece.

Aortic valve stenosis is a degenerative disease affecting increasing number of individuals and characterised by thickening, calcification and fibrosis of the valve resulting in restricted valve motion. Degeneration of the aortic valve is no longer considered a passive deposition of calcium, but an active process that involves certain mechanisms, that is endothelial dysfunction, inflammation, increased oxidative stress, calcification, bone formation, lipid deposition, extracellular matrix (ECM) remodelling and neoangiogenesis. Accumulating evidence indicates an important role for neoangiogenesis (i. Read More

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http://dx.doi.org/10.1080/00015385.2020.1746053DOI Listing

Implication of urine aquaporin-2 levels following cardiac surgery.

Authors:
Teruhiko Imamura

Heart Vessels 2020 Jun 29. Epub 2020 Jun 29.

Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1007/s00380-020-01661-6DOI Listing

Heyde's Syndrome Complicating Management in a Patient With High Bleeding and Thrombotic Risks.

Cureus 2020 May 25;12(5):e8280. Epub 2020 May 25.

Internal Medicine/Cardiovascular Medicine/Interventional Cardiology, University of Maryland School of Medicine, Baltimore, USA.

The association of severe aortic stenosis and gastrointestinal (GI) bleeding is a well-known phenomenon. The pathogenesis involves an acquired deficiency of von Willebrand factor (vWF) due to shear stress resulting in alteration of vWF morphology. This results in in-appropriate cleavage of vWF multimers into smaller dysfunctional fragments. Read More

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http://dx.doi.org/10.7759/cureus.8280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317131PMC

Validation of four-dimensional flow cardiovascular magnetic resonance for aortic stenosis assessment.

Sci Rep 2020 Jun 29;10(1):10569. Epub 2020 Jun 29.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.

The management of patients with aortic stenosis (AS) crucially depends on accurate diagnosis. The main aim of this study were to validate the four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR) methods for AS assessment. Eighteen patients with clinically severe AS were recruited. Read More

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http://dx.doi.org/10.1038/s41598-020-66659-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324609PMC

Mid-term outcomes of Sapien 3 versus Perimount Magna Ease for treatment of severe aortic stenosis.

J Cardiothorac Surg 2020 Jun 29;15(1):157. Epub 2020 Jun 29.

Heart Center, Turku University Hospital, and Department of Surgery, University of Turku, Turku, Finland.

Background: There is limited information on the longer-term outcome after transcatheter aortic valve replacement (TAVR) with new-generation prostheses compared to surgical aortic valve replacement (SAVR). The aim of this study was to compare the mid-term outcomes after TAVR with Sapien 3 and SAVR with Perimount Magna Ease bioprostheses for severe aortic stenosis.

Methods: In a retrospective study, we included patients who underwent transfemoral TAVR with Sapien 3 or SAVR with Perimount Magna Ease bioprosthesis between January 2008 and October 2017 from the nationwide FinnValve registry. Read More

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http://dx.doi.org/10.1186/s13019-020-01203-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325109PMC

Calcific Plug Obstructing the Thoracic Aorta.

Aorta (Stamford) 2020 Feb 29;8(1):23-24. Epub 2020 Jun 29.

Section of Cardiac Surgery, Department of Cardiac Thoracic and Vascular Surgery, University Hospital, Pisa, Italy.

We describe a case of a 57-year-old woman with occlusion of the thoracic aorta due to a calcific plug as an unusual cause of refractory hypertension. Middle aortic syndrome, also known as "," defined as a clinical condition caused by thoracic and/or abdominal aortic stenosis, requires peculiar treatment strategies representing a complex surgical challenge. Read More

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http://dx.doi.org/10.1055/s-0039-1701000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324252PMC
February 2020

Management of atrial fibrillation after transcatheter aortic valve replacement: Challenges and therapeutic considerations.

Trends Cardiovasc Med 2020 Jun 27. Epub 2020 Jun 27.

Barts Heart Centre, St Bartholomew's Hospital, London, UK.

Atrial Fibrillation (AF) is very common among patients with severe aortic stenosis. Moreover, new onset AF (NOAF) is a frequent finding after Transcatheter Aortic Valve Replacement (TAVR). There is a significant impact of AF on outcomes in patients undergoing TAVR including mortality, thrombo-embolic and bleeding events. Read More

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http://dx.doi.org/10.1016/j.tcm.2020.06.007DOI Listing

Impact of Adding Carotid Endarterectomy to Supra-Aortic Trunk Surgical Reconstruction.

Ann Vasc Surg 2020 Jun 26. Epub 2020 Jun 26.

Division of Vascular and Endovascular Surgery, University of Virginia, Charlottesville, VA. Electronic address:

Objectives: Up to 20% of patients requiring open supra-aortic trunk reconstruction (SAT) have significant carotid artery stenosis. The addition of carotid endarterectomy (CEA) to SAT has been described. Yet, additive risks are not well defined and controversy remains as to whether concomitant CEA increases stroke risk. Read More

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http://dx.doi.org/10.1016/j.avsg.2020.06.037DOI Listing

Sex differences in bicuspid aortic valve disease.

Prog Cardiovasc Dis 2020 Jun 26. Epub 2020 Jun 26.

Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Bicuspid aortic valve (BAV), the most frequent congenital heart disease, is characterized by an uneven distribution between sexes. BAV is three to four times more frequent in men than in women which could be associated with a reduced dosage of X chromosome genes. In addition, BAV has a multifactorial inheritance, low penetrance and variable phenotypes that may lead to different form of valve degeneration and dysfunction over time as well as different incidence of aortic valve and vascular complications between men and women. Read More

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http://dx.doi.org/10.1016/j.pcad.2020.06.004DOI Listing

How valvular calcification can affect the outcomes of transcatheter aortic valve implantation.

Expert Rev Med Devices 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiology, Leiden University Medical Center , Leiden, The Netherlands.

Introduction: In transcatheter aortic valve implantation (TAVI), assessment of aortic valve calcification is not as standardized as aortic annulus measurement. Aortic valve calcification is important for stable anchoring of the prosthesis to the aortic annulus. However, excessive aortic valve calcification is related to procedural complications. Read More

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http://dx.doi.org/10.1080/17434440.2020.1789456DOI Listing