299,083 results match your criteria Aortic Stenosis


Using Aorta-Lesion-Attenuation Difference (ALAD) on Preoperative Contrast-Enhanced CT Scan to Differentiate between Malignant and Benign Renal Tumors.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Urology, University of Florida College of Medicine, Gainesville, FL.

Objectives: To evaluate the ability of Aorta-Lesion-Attenuation-Difference (ALAD) to differentiate malignant renal tumors from renal oncocytomas.

Methods: A retrospective review of preoperative CT scans and surgical pathology was performed on patients undergoing partial nephrectomy for small, solid renal masses. ALAD was calculated by measuring the difference in Hounsfield units (HU) between the aorta and the lesion of interest on the same image slice on preoperative CT scan. Read More

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December 2018

Cardio-omentopexy Reduces Cardiac Fibrosis and Heart Failure after Experimental Pressure Overload.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Electronic address:

Background: The pedicled greater omentum has been shown to offer benefit in ischemic heart disease for both animal models and human patients. The impact of cardio-omentopexy in a pressure overload model of left ventricular hypertrophy (LVH) is unknown.

Methods: LVH was created in rats by banding the ascending aorta after right thoracotomy (n=23). Read More

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December 2018

Open Thoracoabdominal Aortic Aneurysm Repair: Contemporary Outcomes for 393 Elective Cases.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Kawasaki Aortic Center, Kawasaki Saiwai Hospital, Japan.

Background: The purpose of this study was to reveal the mid- and long-term mortality rates among patients with thoracoabdominal aortic aneurysm (TAAA) following open TAAA repair (TAAAR) and to clarify the impact of aneurysm type on mortality.

Methods: We retrospectively analyzed data for 393 patients (290 males; age, 63.2 ± 12. Read More

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December 2018
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Association Between Red Blood Cell Transfusion and Clinical Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiology and Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, RI.

Background: We evaluated the association between post-procedural packed red blood cell (PRBC) transfusion and morbidity and mortality in patients undergoing transcatheter aortic valve replacement (TAVR).

Methods: We retrospectively analyzed 429 patients with severe aortic stenosis (AS), who underwent TAVR. Propensity-score adjusted multivariable logistic and Cox regression models were used to determine the association of PRBC transfusion to the composite endpoint of death, myocardial infarction (MI) or stroke at 30 days, in-hospital, and 1-year mortality. Read More

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December 2018

Middle- and long-term outcomes of hybrid technique of complicated Stanford type-B aortic dissection.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiovascular Surgery, the second Hospital of Jilin University, Changchun, Jilin, China, 130041. Electronic address:

Background: To evaluate the middle- and long- clinical outcomes of aortic implantation of stent-grafts under direct vision (hybrid surgical treatment).

Methods: From March 2009 to December 2014, 285 patients presented with type-B aortic dissection. Of these, 35 complicated patients underwent hybrid surgical treatment. Read More

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December 2018

Transforming the experience of aortic valve disease in older patients: a qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiothoracic Surgery, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Aim And Objectives: To explore patients' lived experiences of daily life and coping with recovery after Transcatheter aortic valve implantation (TAVI).

Background: TAVI is increasingly used to treat older patients with severe aortic stenosis with high surgical risk. This novel treatment has been shown to be effective in relieving symptoms, improving survival and prognosis, but its impact on patients' daily life has been sparsely explored. Read More

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December 2018

Surgical outcomes of acute type A aortic dissection in dialysis patients.

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya-ku, Saitama, 330-8503, Japan.

Background: Acute type A aortic dissection (ATAAD) is relatively uncommon in dialysis patients, and characteristics and repair outcomes are not fully understood.

Patients And Methods: Patients with ATAAD (n = 960) were divided into a dialysis group (n = 19) and non-dialysis group (n = 941), depending on whether they required dialysis for preoperative end-stage renal disease (ESRD). Hospital charts and imaging data were reviewed, and characteristics and outcomes were compared between the groups. Read More

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December 2018

Reliability of effective arterial elastance using peripheral arterial pressure as surrogate for left ventricular end-systolic pressure.

J Clin Monit Comput 2018 Dec 14. Epub 2018 Dec 14.

Department Anaesthesia and Intensive Care Units, Humanitas Research Hospital, Humanitas University, Milan, Italy.

To compare the effective arterial elastance (Ea) obtained from the arterial pressure with Ea calculated from left-ventricular (LV) pressure-volume analysis. Experimental study. LV pressure-volume data was obtained with a conductance catheter and arterial pressures were measured via a fluid-filled catheter placed in the proximal aorta, femoral and radial arteries. Read More

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December 2018

A novel software tool for semi-automatic quantification of thoracic aorta dilatation on baseline and follow-up computed tomography angiography.

Int J Cardiovasc Imaging 2018 Dec 14. Epub 2018 Dec 14.

LKEB, LUMC, Leiden, The Netherlands.

A dedicated software package that could semi-automatically assess differences in aortic maximal cross-sectional diameters from consecutive CT scans would most likely reduce the post-processing time and effort by the physicians. The aim of this study was to present and assess the quality of a new tool for the semi-automatic quantification of thoracic aorta dilation dimensions. Twenty-nine patients with two CTA scans of the thoracic aorta for which the official clinical report indicated an increase in aortic diameters were included in the study. Read More

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December 2018

Characteristics and outcomes of patients ≤ 75 years who underwent transcatheter aortic valve implantation: insights from the SOURCE 3 Registry.

Clin Res Cardiol 2018 Dec 14. Epub 2018 Dec 14.

Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.

Background: Current trials and registries of transcatheter valve implantation (TAVI) mostly include patients older than 75 years. Little is known about younger patients who undergo this treatment. We investigated comorbidities among patients < 75 years old who underwent TAVI in the SAPIEN 3™ European post-approval SOURCE 3 Registry, and analysed outcomes at 30 days and 1 year. Read More

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December 2018

[Image-based screening].

Authors:
G Layer

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Zentralinstitut für Diagnostische und Interventionelle Radiologie, Klinikum Ludwigshafen gGmbH, Bremserstraße 79, 67063, Ludwigshafen, Deutschland.

Screening is a special issue in medical questions concerning disease prevention. Preconditions for screening are clearly defined by the World Health Organization. High prevalence, effectiveness of therapy, availability of accepted test procedure and consensus concerning the economic concerns are necessary for successful implementation of a screening program. Read More

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December 2018

Serum rantes, transforming growth factor-β1 and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Interventional Cardiology, Jagiellonian University College of Medicine and the John Paul II Hospital, Cracow, Poland.

Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation and immune-cell recruitment. Interleukin -6 (IL-6) is used as a general index of severity of the chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) is an immune biomarker potentially involved in the regulation of valve fibrosis and calcification. Read More

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Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, Wash. Electronic address:

Objective: Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography.

Methods: This retrospective review included patients with TBAD presenting between 1990 and 2016. Read More

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December 2018

Survival after abdominal aortic aneurysm repair is affected by socioeconomic status.

J Vasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Division of Vascular Surgery, Henry Ford Hospital, Detroit, Mich. Electronic address:

Objective: The association between socioeconomic status (SES) and outcome after abdominal aortic aneurysm (AAA) repair is largely unknown. This study aimed to determine the influence of SES on postoperative survival after AAA repair.

Methods: Patients undergoing surgical treatment of AAA at a tertiary referral center between January 1993 and July 2013 were retrospectively collected. Read More

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December 2018

Focused Resident Education and Engagement in Quality Improvement Enhances Documentation, Shortens Hospital Length of Stay, and Creates a Culture of Continuous Improvement.

J Surg Educ 2018 Dec 12. Epub 2018 Dec 12.

Comprehensive Aortic Center, Cardiovascular Thoracic Institute, Keck Medical Center of University of Southern California, Los Angeles, California. Electronic address:

Purpose: System-based practice with an emphasis on quality improvement (QI) is a recent initiative for the American College of Surgeons and a core-competency for surgical trainees. Few surgical training programs have a curriculum for hospital-based QI.

Methods: Our vascular surgery service implemented several QI initiatives focused on decreasing length of stay (LOS) by targeting resident education and engagement. Read More

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December 2018

How Can We Ensure Vascular Surgical Trainees Become Competent in Open Aortic Surgery in the Future Training Environment?

Eur J Vasc Endovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Vascular Surgery, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:

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December 2018

Commentary Regarding "Outcomes After One Stage Versus Two Stage Open Repair of Type II Thoraco-abdominal Aortic Aneurysms".

Eur J Vasc Endovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

German Aortic Centre Hamburg, Department of Vascular Medicine, University Heart Centre, Hamburg, Germany. Electronic address:

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December 2018

Predissection-derived geometric and distensibility indices reveal increased peak longitudinal stress and stiffness in patients sustaining acute type A aortic dissection: Implications for predicting dissection.

J Thorac Cardiovasc Surg 2018 Nov 3. Epub 2018 Nov 3.

Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pa; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pa; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa; Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, Pa; Center for Thoracic Aortic Disease, University of Pittsburgh, Pittsburgh, Pa. Electronic address:

Objective: To assess ascending aortic distensibility and build geometry and distensibility-based patient-specific stress distribution maps in patients sustaining type A aortic dissection (TAAD) using predissection noninvasive imaging.

Methods: Review of charts from patients undergoing surgical repair of TAAD (n = 351) led to the selection of a subset population (n = 7) with 2 or more predissection computed tomography angiography scans and echocardiograms at least 1 year before dissection. Ascending aortic wall biomechanical properties (aortic strain, distensibility, and stiffness) were compared with age- and size-matched nondissected nonaneurysmal controls. Read More

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November 2018
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Assuring High Quality for Transcatheter Aortic Valve Replacement While Achieving Adequate Patient Access: What's the Controversy?

Cardiovasc Revasc Med 2018 Dec;19(8):907-909

Department of Medicine, Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado.

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December 2018

Insect heart rhythmicity is modulated by evolutionarily conserved neuropeptides and neurotransmitters.

Curr Opin Insect Sci 2018 Oct 11;29:41-48. Epub 2018 Jun 11.

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA. Electronic address:

Insects utilize an open circulatory system to transport nutrients, waste, hormones and immune factors throughout the hemocoel. The primary organ that drives hemolymph circulation is the dorsal vessel, which is a muscular tube that traverses the length of the body and is divided into an aorta in the head and thorax, and a heart in the abdomen. The dorsal vessel is myogenic, but its rhythmicity is modulated by neuropeptides and neurotransmitters. Read More

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October 2018

The association between natural gas well activity and specific congenital anomalies in Oklahoma, 1997-2009.

Environ Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Background: Natural gas drilling may pose multiple health risks, including congenital anomalies, through air pollutant emissions and contaminated water. Two recent studies have evaluated the relationship between natural gas activity and congenital anomalies, with both observing a positive relationship.

Objectives: We aimed to evaluate whether residence near natural gas wells is associated with critical congenital heart defects (CCHD), neural tube defects (NTD), and oral clefts in Oklahoma, the third highest natural gas producing state in the US. Read More

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December 2018

Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.

Biomed Pharmacother 2019 Jan 5;109:945-956. Epub 2018 Nov 5.

Pain Medicine Center, The Third Hospital of Hebei Medical University, 139 Ziqiang Road, Shijiazhuang 050051, China. Electronic address:

Salvianic acid A (SAA) is an active water-soluble constituent derived from Salvia miltiorrhiza Bge that is used extensively in the treatment of angiocardiopathy in China. However, few reports have investigated the therapeutic effect and the underlying mechanisms of SAA on atherosclerosis (AS). This study examines the protective mechanisms of SAA on AS in vivo and in vitro. Read More

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January 2019

mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5.

Biomed Pharmacother 2019 Jan 30;109:2409-2414. Epub 2018 Nov 30.

Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Electronic address:

Macrophages' function play a vital role in the progression of atherosclerosis (AS), and miRNAs can modulate inflammatory cytokine secretion, lipid uptake and apoptosis of macrophages. miR-152 is down-regulated in the serum samples of AS patients and inhibits the migration of human umbilical vein endothelial cell, suggesting that miR-152 exerts a role in the atherogenesis. Nevertheless, the function of miR-152 in the inflammatory reaction of macrophages remains unexplored. Read More

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January 2019
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Endothelium-dependent and endothelium-independent vasorelaxant effects of tiliacorinine 12'-O-acetate and mechanisms on isolated rat aorta.

Biomed Pharmacother 2019 Jan 26;109:2090-2099. Epub 2018 Nov 26.

Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Tiliacorinine 12'-O-acetate is a modified analog of Tiliacorinine, a major compound in Tiliacora triandra. The present study explored the vasorelaxation property of tiliacorinine 12'-O-acetate and its mechanism in isolated rat aorta using the organ bath technique. Tiliacorinine 12'-O-acetate exhibited concentration-dependent (10-10 M) vasorelaxation in endothelium-intact rings (E = 93. Read More

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January 2019
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Effects of atorvastatin and/or probucol on recovery of atherosclerosis in high-fat-diet-fed apolipoprotein E-deficient mice.

Biomed Pharmacother 2019 Jan 13;109:1445-1453. Epub 2018 Nov 13.

Department of Geratology, The Second Hospital of Tianjin Medical University, PR China. Electronic address:

Introduction: We have investigated the possible effects and mechanism of atorvastatin, a statin, and/or probucol, a powerful antioxidant used to lower cholesterol before 1995, on the atherosclerosis development.

Methods: Apolipoprotein-E-deficient (ApoE) mice fed with the high fat diet were randomly divided into 3 groups (n = 10/each group): Placebo, Atorvastatin (10 mg/ kg/d), and atorvastatin (10 mg/kg/d) plus probucol (10 mg/kg/d) groups. C57BL/6 J mice were fed with normal diet as the control group (n = 10). Read More

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January 2019

Comparison of effects of MHBFC on cardiac hypertrophy after banding of the abdominal aorta in wild-type mice and eNOS knockout mice.

Biomed Pharmacother 2019 Jan 7;109:1221-1232. Epub 2018 Nov 7.

Pharmaceutical College, Guangxi Medical University, Nanning, 530021, Guangxi, PR China. Electronic address:

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January 2019

Rhomboid intercostal and subserratus plane block for transapical transcatheter aortic valve implantation.

Authors:
Hironobu Ueshima

J Clin Anesth 2018 Dec 11;54:146. Epub 2018 Dec 11.

Department of Anesthesiology, Showa University Hospital, Hatanodai Shinagawa-ku, Tokyo, Japan. Electronic address:

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December 2018

Neutral/negative α-AR antagonists and calcium channel blockers at comparison in functional tests on guinea-pig smooth muscle and myocardium.

Pharmacol Rep 2018 Oct 11;71(1):128-132. Epub 2018 Oct 11.

Dipartimento di Farmacia e Biotecnologie, Università degli Studi di Bologna, Bologna, Italy. Electronic address:

Background: Constitutive (agonist-independent) activity is a prerogative of many G protein-coupled receptors (GPCRs) including α-adrenoceptors (α-ARs). Inhibition of such an activity at α-AR subtypes by antagonists with negative efficacy is difficult to be adequately tested.

Methods: In the present experimental approach, we compared the activity of three calcium channel blockers (nifedipine, diltiazem and verapamil) and of three potent benzodioxane-based α-AR antagonists, differing for subtype selectivity and inverse agonist properties, in producing smooth muscle relaxation and negative inotropy under the same test conditions. Read More

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October 2018

TRPC channels mediated calcium entry is required for proliferation of human airway smooth muscle cells induced by nicotine-nAChR.

Biochimie 2018 Dec 11. Epub 2018 Dec 11.

Respiratory Medicine, Hunan Provincial People's Hospital, No. 61 Jiefang Xi Road, Changsha, 410219, Hunan, PR China; Institute of Respiratory Medicine, Changsha Medical College, No. 1501 Leifeng Road, Changsha, 410219, Hunan, PR China. Electronic address:

The present study was designed to explore the role of transient receptor potential canonical 3 (TRPC3) in nicotine-induced chronic obstructive pulmonary disease (COPD) and its underlying mechanism. In this study, the expression and localization of α5 nicotinic acetylcholine receptor (α5-nAchR) in lung tissues were determined by western blotting and immunohistochemistry. The quantitative real-time PCR (qRT-PCR) analysis was performed to examine the mRNA expression levels of α5-nAchR and TRPC3 in human airway smooth muscle cells (HASMCs). Read More

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December 2018

Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia.

Physiol Behav 2018 Dec 11. Epub 2018 Dec 11.

Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey; Kocaeli University, Experimental Medical Research and Application Centre, Kocaeli, Turkey.

Diabetes is one of the risk factors for the development of vascular dementia (VD), leading to endothelial dysfunction and cognitive impairment. Resveratrol has been shown to have antioxidant, antiinflammatory, and neuroprotective effects. The previous studies have also reported that resveratrol improves cognitive and vascular endothelial functions in several pathological conditions. Read More

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December 2018
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Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

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December 2018
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Repair of Untreated Older Patients with Tetralogy of Fallot with Major Aortopulmonary Collaterals.

Ann Thorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Lucile Packard Children's Hospital Stanford, Clinical and Translational Research Program; Stanford University School of Medicine; Department of Cardiothoracic Surgery, Lucile Packard Children's Hospital Stanford, Clinical and Translational Research Program; Stanford University School of Medicine.

Background: Our programmatic approach to tetralogy of Fallot with major aortopulmonary collaterals emphasizes single-stage unifocalization with complete intracardiac repair during infancy. Little is known about suitability for complete repair in patients beyond infancy. We sought to analyze outcomes of our approach in older patients with previously untreated tetralogy of Fallot with major aortopulmonary collaterals. Read More

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December 2018

Minimally invasive triple valve surgery: The Rome approach.

Multimed Man Cardiothorac Surg 2018 Dec 4;2018. Epub 2018 Dec 4.

Department of Cardiac Surgery and Transplantation, S. Camillo Hospital, Rome, Italy.

Although the benefits of minimally invasive cardiac surgery are well recognized, most surgeons have little experience in the treatment of triple valve disease through a minithoracotomy approach. In this video tutorial, we present a case of concomitant aortic valve replacement with mitral and tricuspid valve repair through a lateral minithoracotomy. Read More

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December 2018

One-stage transmediastinal surgical approach for extensive aortic pathology.

Multimed Man Cardiothorac Surg 2018 Dec 4;2018. Epub 2018 Dec 4.

SS. Antonio e Biagio e Cesare Arrigo Hospital of Alessandria Piedmont Italy.

"One-stage" transmediastinal replacement of the thoracic aorta provides an alternative treatment to single or multiple stage hybrid procedures for patients with ascending, arch, and descending thoracic aorta aneurysm. The patient is placed on bypass and cooled. During circulatory arrest, after surgical treatment of the aortic valve and root where appropriate, the entire ascending aorta is excised and the transverse arch is opened longitudinally. Read More

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December 2018

HeartMate 3 left ventricular assist device minimally invasive off-pump implantation.

Authors:
Paolo Centofanti

Multimed Man Cardiothorac Surg 2018 Dec 4;2018. Epub 2018 Dec 4.

With advancements in mechanical circulatory support technology, and limitations in donor supply for heart transplantation, the use of left ventricular assist devices (LVADs) has increased significantly in recent years. Multiple studies have shown that minimally invasive cardiac surgery can improve outcomes, with shorter hospital stays, decreased morbidity, faster recovery and ambulation, and lower total hospital costs. The current generation of centrifugal continuous-flow pumps is miniaturized and makes minimally invasive approaches increasingly practicable. Read More

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December 2018
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Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Edwards Lifesciences, Irvine, California.

Objectives: To explore the impact of post-procedure delirium on resource utilization following transcatheter and surgical aortic valve replacement (TAVR and SAVR, respectively).

Background: Postprocedure delirium is associated with worse long-term survival after TAVR and SAVR. However, its effect on resource utilization has been understudied. Read More

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December 2018
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A novel autosomal dominant mutation in SOX18 resulting in a fatal case of hypotrichosis-lymphedema-telangiectasia syndrome.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, University of California, San Diego and Rady Children's Hospital, San Diego, California.

Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) is a rare disorder caused by autosomal recessive and autosomal dominant mutations in SOX18. This gene encodes a transcription factor involved in the regulation and development of the human vasculature, lymphatic, and integumentary systems. Individuals with HLTS develop varying degrees of hypotrichosis, lymphedema, and telangiectasias. Read More

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December 2018
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An update on the management and outcomes of cancer patients with severe aortic stenosis.

Catheter Cardiovasc Interv 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Objectives: We compared the outcomes of aortic valve replacement (AVR) by transcatheter (TAVR) and surgical (SAVR) routes with those of optimal medical management in patients with cancer and severe aortic stenosis (AS).

Background: Cancer therapy requires optimal cardiac output; however, the treatment of AS in cancer patients is not established.

Methods: Cancer patients with severe AS during January 2009 through February 2018 at a large cancer center were identified. Read More

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December 2018
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Safety outcomes of new versus old generation transcatheter aortic valves.

Catheter Cardiovasc Interv 2018 Dec 13. Epub 2018 Dec 13.

Cardiology department, Tel Aviv Sourasky Medical Center, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To compare procedural outcomes of transcatheter aortic valve implantation (TAVI) patients who were implanted with older versus newer generation valves.

Background: The current evidence base for improved safety of the newer commercially available TAVI valves is limited.

Methods: A retrospective analysis of the Israeli multicenter TAVI registry was performed. Read More

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December 2018

Conduction recovery following pacemaker implantation after transcatheter aortic valve replacement.

Pacing Clin Electrophysiol 2018 Dec 13. Epub 2018 Dec 13.

Division of Cardiology, Bluhm Cardiovascular Institute, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Background: Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis. A frequent complication of TAVR is high grade or complete atrioventricular (AV) block requiring a permanent pacemaker (PPM). There is little data on the long-term dependency on pacing after TAVR. Read More

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December 2018

Redo mitral valve surgery following prior mitral valve repair.

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: The optimal treatment strategy following a failed mitral valve repair remains unclear. This study evaluated early and long-term outcomes of redo mitral valve repair (MVr) and replacement (MVR) after prior mitral valve repair.

Methods: Patients undergoing redo mitral valve surgery after prior mitral valve repair at a single institution between 2002 and 2014 were reviewed. Read More

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December 2018
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Permanent pacemaker implantation and paravalvular leak rates following sutureless aortic valve operations.

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

University of Arizona, Banner University Medical Center, Phoenix, Arizona.

Background: Permanent pacemaker (PPM) implantation and paravalvular leak (PVL) rates after sutureless aortic valve replacement (SuAVR) vary widely. The aim of this meta-analysis was to examine the incidence of new PPM implantation and PVL after SuAVR.

Methods: Studies evaluating PPM implantation and PVL rates after SuAVR were searched in Medline/PubMed, Ovid Journals, Clinicaltrials. Read More

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December 2018

Gastric hemorrhage due to splenomegaly following repair of a type A aortic dissection.

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

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December 2018

The innominate artery-The forgotten cannulation site for thoracic aortic surgery.

Authors:
Harold L Lazar

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

From the Division of Cardiac Surgery, the Boston University School of Medicine, Boston, Massachusetts.

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December 2018

Innominate artery cannulation in aortic surgery: A systematic review.

J Card Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Aortovascular Surgery, Manchester Royal Infirmary, Manchester, UK.

Objective: The innominate artery is considered an alternative site for establishing cardiopulmonary bypass in surgical procedures involving the thoracic aorta. This systematic review examines the use of innominate artery cannulation in aortic surgery.

Methods: A systematic literature search was undertaken among the four major databases (PubMed, Embase, Scopus, and Ovid) to identify all studies that utilized innominate artery cannulation for establishing cardiopulmonary bypass and providing cerebral perfusion in thoracic aortic surgery. Read More

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December 2018
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Quantification of rheumatic mitral stenosis severity with three-dimensional vena contracta area.

Echocardiography 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Marmara University Medical Center, Istanbul, Turkey.

Introduction: Rheumatic mitral stenosis (MS) is an important health issue in developing countries. Assessment of the correct mitral valve area (MVA) is essential for the timing of intervention. Most of the parameters for the assessment of rheumatic MS are derived from Two-dimensional (2D) echocardiography. Read More

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December 2018

Abnormal fetal cerebral and vascular development in hypoplastic left heart syndrome.

Prenat Diagn 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Hospital for Sick Children, Toronto, ON.

Objective: To assess the cerebral and vascular development in fetuses with hypoplastic left heart syndrome (HLHS).

Methods: Pregnant women carrying fetuses diagnosed with HLHS who decided to interrupt their pregnancies were included in our study. Aortic size and blood flow were assessed based from fetal echocardiography. Read More

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December 2018

Transcatheter valve-in-valve for failing bioprosthetic aortic valve: Usually a good idea.

Catheter Cardiovasc Interv 2018 Dec;92(7):1412-1413

Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, New York.

Use of bioprosthetic implants for surgical aortic valve replacements (SAVR) has been increasing in the recent years Surgical redo AVRs for failed surgical aortic bioprostheses have been traditionally considered the standard practice; however, in patients with higher surgical risk scores, transcatheter valve-in-valve aortic valve replacements are being commonly performed There is scarcity of data comparing these two approaches in this complex patient cohort Available data suggest that transcatheter ViV aortic valve replacement is generally a safe approach once some caveats are accounted for. Read More

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December 2018

Right Mini-Thoracotomy Subaortic Membrane Resection.

Innovations (Phila) 2018 Nov/Dec;13(6):428-432

From the Division of Cardiac Surgery, University of Rochester Medical Center, Rochester, NY USA.

Objective: Subaortic membrane is an anatomical intracardiac anomaly that may cause discrete subaortic stenosis and aortic insufficiency. Patients requiring subaortic membrane resection may benefit from a minimally invasive approach; however, subaortic membranes are typically resected through a median sternotomy. We present our initial clinical experience of adult patients who have undergone a mini-thoracotomy subaortic membrane resection. Read More

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December 2018