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    1 OF 468

    Outcomes for the Commercial Use of Self-Expanding Prostheses in Transcatheter Aortic Valve Replacement: A Report From the STS/ACC TVT Registry.
    JACC Cardiovasc Interv 2017 Oct;10(20):2090-2098
    Beth Israel Deaconess Medical Center, Boston, Massachusetts.
    Objectives: The authors sought to compare the outcomes of commercial transcatheter aortic valve replacement (TAVR) with the repositionable Evolut R platform to those observed with the CoreValve device in the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry.

    Background: TAVR continues to evolve, with rapid adoption of iterative changes for commercial practice. Insight into the outcomes of this adoption is needed. Read More

    Treatment of a degenerated sutureless Sorin Perceval® valve using an Edwards SAPIEN 3.
    Interact Cardiovasc Thorac Surg 2017 Oct 10. Epub 2017 Oct 10.
    Department of Cardiology, Heart Center Leipzig, University Hospital, Leipzig, Germany.
    Valve-in-valve implantation is an alternative to reoperation for patients with degenerated bioprostheses. This case report presents a 75-year-old woman presenting with worsening dyspnoea according New York Heart Association (NYHA) Class III after she had received a Sorin Perceval® S sutureless valve due to severe aortic valve stenosis 5 years ago. Echocardiography revealed a degenerated Perceval valve with severe valvular aortic regurgitation and stenosis. Read More

    Surgical strategy for aortic arch reconstruction after the Norwood procedure based on numerical flow analysis.
    Interact Cardiovasc Thorac Surg 2017 Oct 17. Epub 2017 Oct 17.
    Department of Surgery I, Toyama University School of Medicine, Toyama City, Toyama, Japan.
    Objectives: Inefficient aortic flow after the Norwood procedure is known to lead to the deterioration of ventricular function due to an increased cardiac workload. To prevent the progression of aortic arch obstruction, arch reconstruction concomitant with second-stage surgery is recommended. The aim of this study was to determine the indications for reconstruction based on numerical simulation and to reveal the morphology that affects the haemodynamic parameters. Read More

    Sinus of Valsalva aneurysms with concomitant aortic insufficiency: how should the aortic valve be managed?
    Interact Cardiovasc Thorac Surg 2017 Sep 14. Epub 2017 Sep 14.
    Department of Cardiac Surgery, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
    Objectives: Sinus of Valsalva aneurysms (SVAs) are rare and are often complicated by aortic insufficiency (AI). Treating AI is important for achieving good long-term results in patients with SVA. Here, we have summarized our experience with the surgical management of patients with SVA with concomitant AI. Read More

    Full metal jacket: transfemoral aortic valve implantation for regurgitant valve after endovascular aortic repair†.
    Interact Cardiovasc Thorac Surg 2017 Jul 25. Epub 2017 Jul 25.
    Department of Cardiology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
    Transfemoral aortic valve implantation has become an almost routine interventional procedure for severe aortic stenosis in high-risk patients. Over time an increased number of experiences has led to unusual procedures. In this report, we present a successful valve-in-valve transfemoral aortic valve implantation in a patient with aortic regurgitation, who previously had debranching and thoracic endovascular aortic repair operations. Read More

    Sutureless aortic valve replacement versus transcatheter aortic valve implantation: a meta-analysis of comparative matched studies using propensity score matching.
    Interact Cardiovasc Thorac Surg 2017 Sep 11. Epub 2017 Sep 11.
    Cardiothoracic Center, Istituto Clinico Sant'Ambrogio, Gruppo Ospedaliero San Donato, Milan, Italy.
    Objectives: The aim of this meta-analysis was to compare outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) with those undergoing surgical aortic valve replacement using sutureless valves.

    Methods: A systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was performed.

    Results: No randomized controlled trials were identified. Read More

    Does mitral valve repair matter in infants with ventricular septal defect combined with mitral regurgitation?
    Interact Cardiovasc Thorac Surg 2017 Aug 14. Epub 2017 Aug 14.
    Department of Heart Valves Surgery, Siberian Biomedical Research Center, Ministry of Health Russian Federation, Novosibirsk, Russian Federation.
    Objectives: This study aimed to assess mitral valve function after repair of ventricular septal defect (VSD) combined with mitral regurgitation (MR) in the mid-term follow-up period, to evaluate the clinical utility of simultaneous mitral valve repair (MVR).

    Methods: From June 2005 to March 2014, 60 patients with VSD and MR underwent surgical treatment. After performing propensity score analysis (1:1) for the entire sample, 46 patients were selected and divided into 2 groups: those with VSD closure and MVR (VSD + MVR, 23 patients) and those with VSD closure without mitral valve intervention (VSD only, 23 patients). Read More

    One-stage definitive repair of complete atrioventricular septal defect and pulmonary atresia with major aortopulmonary collateral arteries.
    Interact Cardiovasc Thorac Surg 2017 Oct 11. Epub 2017 Oct 11.
    Department of Cardiovascular Surgery, Mt. Fuji Shizuoka Children's Hospital, Shizuoka, Japan.
    Pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries is considered the most severe end of the tetralogy of Fallot spectrum, whereas complete atrioventricular septal defect associated with tetralogy of Fallot is a rare congenital defect. However, the combination of pulmonary atresia, major aortopulmonary collateral artery and complete atrioventricular septal defect is extremely rare, and surgical repair has not been reported. We describe a successful, 1-stage correction in a 7-month-old boy with this condition, who had an additional complication of a single aortic outlet from the right ventricle and significant atrioventricular valve regurgitation. Read More

    A new technique to implant a transcatheter inflatable, fully repositionable prosthesis in aortic stenosis with severe asymmetric calcification.
    Interact Cardiovasc Thorac Surg 2017 Aug 1. Epub 2017 Aug 1.
    Department of Cardiac Surgery, University Hospital Rostock, Rostock, Germany.
    Objectives: In contrast to stented transcatheter aortic valves, the Direct Flow Medical (DFM) valve is a stentless bovine aortic bioprosthesis mounted in a non-metallic inflatable frame. Hence, severe asymmetric annular calcification may result in residually elevated transaortic pressure gradients after DFM implantation. We present a novel intraprocedural dilatation (IDIL) technique for successful implantation of the DFM valve in the presence of complex annular calcification. Read More

    Reliability of transcardiopulmonary thermodilution cardiac output measurement in experimental aortic valve insufficiency.
    PLoS One 2017 19;12(10):e0186481. Epub 2017 Oct 19.
    Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Background: Monitoring cardiac output (CO) is important to optimize hemodynamic function in critically ill patients. The prevalence of aortic valve insufficiency (AI) is rising in the aging population. However, reliability of CO monitoring techniques in AI is unknown. Read More

    Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene.
    BMC Med Genet 2017 Oct 18;18(1):116. Epub 2017 Oct 18.
    Center for Cardiovascular Genetics, Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, 6770 Bertner Street, DAC900, Houston, TX, 77030, USA.
    Background: Mutations in LMNA gene, encoding Lamin A/C, cause a diverse array of phenotypes, collectively referred to as laminopathies. The most common manifestation is dilated cardiomyopathy (DCM), occurring in conjunction with variable skeletal muscle involvement but without involvement of the coronary arteries. Much less commonly, LMNA mutations cause progeroid syndromes, whereby an early-onset coronary artery disease (CAD) is the hallmark of the disease. Read More

    Root aneurysm following aortic valve replacement 20 years after an arterial switch operation.
    J Card Surg 2017 Oct 18. Epub 2017 Oct 18.
    Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan.
    Late development of annuloaortic ectasia (AAE) and progression of aortic regurgitation (AR) are widely recognized outcomes following an arterial switch operation (ASO). We treated a 29-year-old male with AAE and rapid aortic root expansion, who underwent ASO as a neonate and aortic valve replacement (AVR) as an adult. He was diagnosed as having dextro-(D-loop) transposition of the great arteries after birth and underwent ASO at the age of 13 months. Read More

    Preliminary investigation of orally administered benazepril in horses with left-sided valvular regurgitation.
    Equine Vet J 2017 Oct 17. Epub 2017 Oct 17.
    Department of Small Animal Medicine and Surgery, College of Medicine, University of Georgia, Athens, Georgia, USA.
    Background: Despite the paucity of data available, orally administered angiotensin-converting enzyme (ACE) inhibitors are empirically used in horses with valvular regurgitation.

    Objective: Evaluate the echocardiographic and hormonal changes in response to oral benazepril in horses with left-sided valvular regurgitation.

    Study Design: Prospective, randomised double-blind, placebo-controlled trial. Read More

    [Acute aortic regurgitation due to infective endocarditis].
    Medicina (B Aires) 2017 ;77(5):373-381
    Instituto de Cardiología y Cirugía Cardiovascular, Hospital Universitario Fundación Favaloro.
    Acute aortic regurgitation (AAR) due to infective endocarditis (IE) is a serious disease and usually requires surgical treatment. Our study aims to compare the clinical, echocardiographic, and microbiological characteristics as well as in-hospital outcome of patients with AAR according to the severity of heart failure (HF) and to evaluate predictors of in-hospital mortality in a tertiary centre. In a prospective analysis, we compared patients with NYHA functional class I-II HF (G1) vs. Read More

    Machine-learning phenotypic classification of bicuspid aortopathy.
    J Thorac Cardiovasc Surg 2017 Sep 14. Epub 2017 Sep 14.
    Department of Thoracic and Cardiovascular Surgery, Miller Family Heart and Vascular Institute, Cleveland, Ohio.
    Background: Bicuspid aortic valves (BAV) are associated with incompletely characterized aortopathy. Our objectives were to identify distinct patterns of aortopathy using machine-learning methods and characterize their association with valve morphology and patient characteristics.

    Methods: We analyzed preoperative 3-dimensional computed tomography reconstructions for 656 patients with BAV undergoing ascending aorta surgery between January 2002 and January 2014. Read More

    A Case of Infective Endocarditis and Spinal Epidural Abscess Caused by Streptococcus mitis Bacteremia.
    Case Rep Infect Dis 2017 5;2017:7289032. Epub 2017 Sep 5.
    Case Western Reserve University School of Medicine, Cleveland, OH, USA.
    A 57-year-old man presented with abdominal pain, hematemesis, and melena. He reported taking high-dose ibuprofen for back pain and drinking several 24-ounce beers daily. Examination was remarkable for icteric sclera, poor dentition, tachycardia, and crescendo-decrescendo murmur at right upper sternal border, radiating to the carotids. Read More

    Two Reports of Quadricuspid Aortic Valve With Aortic Insufficiency.
    Rev Cardiovasc Med 2017 ;18(2):88-91
    Department of Cardiology, Cork University Hospital, Cork, Ireland.
    We report two cases of a quadricuspid aortic valve with severe aortic incompetence. Both patients presented with dyspnea on exertion. Their physical examinations demonstrated wide pulse pressures with diastolic murmurs. Read More

    [Aortitis Syndrome Requiring Redo Bentall Procedure with Coronary Artery Bypass Grafting due to Graft Detachment;Report of a Case].
    Kyobu Geka 2017 Oct;70(11):948-951
    Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan.
    A 53-year-old woman was referred to us for reoperation of aortic root. Twenty-three years ago, she was diagnosed with aortitis and suffered from annuloaortic ectasia, aortic regurgitation, severe stenosis of left carotid and subclavian arteries and occulusion of the main trunk of left coronary artery. The left coronary system was perfused by collateral arteries from right coronary artery. Read More

    [Safety and feasibility of sheathless transfemoral aortic valve implantation].
    Zhonghua Xin Xue Guan Bing Za Zhi 2017 Sep;45(9):782-785
    Coronary Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
    Objective: To investigate the safety and feasibility of sheathless transfemoral aortic valve replacement (TAVR). Methods: In this prospective study, we enrolled 23 patients with severe aortic stenosis (AS) who were inoperable or at high-risk for surgical aortic valve replacement operation in Fuwai hospital From September 2012 to June 2015. Multislice spiral CT and angiography of femoral artery showed that all patients had minimal femoral artery diameters (<6. Read More

    Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve.
    Eur Heart J 2017 Oct 6. Epub 2017 Oct 6.
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.
    Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may have important implications for TAVR. Read More

    Large-scale assessment of aortic stenosis: facing the next cardiac epidemic?
    Eur Heart J Cardiovasc Imaging 2017 Sep 28. Epub 2017 Sep 28.
    Department of Cardiology, CIBERCV. University Alcala de Henares, Hospital Ramon y Cajal, Carretera de Colmenar Km 9.100, Madrid 28034, Spain.
    Aims: Aortic stenosis (AS) is the most frequent valvular disease in developed countries. As society grows older, the prevalence of AS increases. However, the real burden, current aetiology, severity distribution, and echocardiographic patterns of AS are not fully clear. Read More

    Randomized comparison of balloon aortic valvuloplasty performed with or without rapid cardiac pacing: The pacing versus no pacing (PNP) study.
    J Interv Cardiol 2017 Oct 11. Epub 2017 Oct 11.
    Cardiology Unit, Cardio-Thoraco-Vascular Department, University Hospital of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
    Objectives: To compare the effectiveness and safety of balloon aortic valvuloplasty (BAV) performed with or without rapid ventricular pacing (RP).

    Background: BAV technique is poorly standardized.

    Methods: One hundred consecutive patients were randomly assigned 1:1 between BAV performed with or without RP. Read More

    Prevalence and Outcomes of Left-Sided Valvular Heart Disease Associated With Chronic Kidney Disease.
    J Am Heart Assoc 2017 Oct 11;6(10). Epub 2017 Oct 11.
    Division of Cardiology, Department of Medicine, Duke University, Durham, NC.
    Background: Chronic kidney disease (CKD) is an adverse prognostic marker for valve intervention patients; however, the prevalence and related outcomes of valvular heart disease in CKD patients is unknown.

    Methods And Results: Included patients underwent echocardiography (1999-2013), had serum creatinine values within 6 months before index echocardiogram, and had no history of valve surgery. CKD was defined as diagnosis based on the International Classification of Diseases, Ninth Revision or an estimated glomerular filtration rate <60 mL/min per 1. Read More

    Transcatheter Aortic Valve Implantation In Patients With a Large Aortic Annulus.
    Heart Lung Circ 2017 Sep 28. Epub 2017 Sep 28.
    Green Lane Cardiovascular Service (Cardiology), Auckland Hospital, Auckland, New Zealand.
    Background: As the indications for transcatheter aortic valve implantation (TAVI) have expanded, so to have the demands on interventionists to allow as many patients to access this technology as possible.

    Methods: We retrospectively reviewed our TAVI database for patients who had received a 29mm SAPIEN 3 valve despite having an annular area greater than the manufacturer-recommended upper limit of 683mm(2), as determined by multi-detector computed tomography (MDCT). Procedural and inpatient outcome data were collected. Read More

    Videodensitometric quantification of paravalvular regurgitation of a transcatheter aortic valve: in-vitro validation.
    EuroIntervention 2017 Oct 10. Epub 2017 Oct 10.
    Department of Cardiology, the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
    Aims: Videodensitometric assessment of aortography provides a periprocedural quantitation of prosthetic valve regurgitation (PVR) after transcatheter aortic valve implantation. We sought to compare the videodensitometric parameters of PVR severity to the regurgitation fraction (RF) in a controlled in-vitro setting.

    Methods And Results: In a mock circulation system, a transcatheter balloon-expandable valve inserted at the aortic valve position was gradually deformed to induce different grades of paravalvular leakage and the RF was measured with a transonic flow probe. Read More

    Impact of Concomitant Mitral Regurgitation on Transvalvular Gradient and Flow in Severe Aortic Stenosis - A Systematic ex-vivo Analysis of a Subentity of Low-Flow Low-Gradient Aortic Stenosis.
    EuroIntervention 2017 10 10. Epub 2017 Oct 10.
    University Heart Center Jena, Jena, Germany.
    Aims: Evaluation of aortic stenosis(AS) is based on measurement of mean transvalvular gradient(MPG), flow velocity(vmax) and aortic valve area(AVA). Objective of the present study was to analyse the impact of systemic hemodynamic variables and concomitant mitral regurgitation(MR) on aortic MPG, vmax and AVA in severe AS.

    Methods And Results: A pulsatile circulatory model was designed to study function and interdependence of stenotic aortic and insufficient mitral prosthetic valves (n=8; effective regurgitation orifice (EROA)<0. Read More

    Congenital unruptured aneurysm of sinus of Valsalva, quadricuspid aortic valve, and ascending aortic aneurysm associated with genetic leukoencephalopathy in an infant: A new syndrome?
    Echocardiography 2017 Oct 10. Epub 2017 Oct 10.
    Rajaee Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
    We report a 15-month-old female with unruptured noncoronary sinus of Valsalva anreurysm (SOVA) associated with quadricuspid aortic valve, ascending aortic aneurysm (AAA), moderate aortic insufficiency, mild mitral insufficiency, genetic leukoencepaholpathy, developmental delay and mild mixed aminoaciduria. She was referred for evaluation of a cardiac murmur. Initial echocardiographic examination showed the aneurysm as a round cyst in the right atrium which changed in size during systole and diastole. Read More

    Transapical transcatheter aortic valve replacement with a novel transcatheter aortic valve replacement system in high-risk patients with severe aortic valve diseases.
    J Thorac Cardiovasc Surg 2017 Sep 15. Epub 2017 Sep 15.
    Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
    Objectives: The clinical experience of a novel transapical transcatheter aortic valve replacement system, the J-Valve (JC Medical Inc, Burlingame, Calif), in high-risk patients with severe aortic valve diseases is limited.

    Methods: A total of 107 high-risk patients (mean age, 74.4 ± 5. Read More

    Hospital outcomes of transcatheter versus surgical aortic valve replacement in female in the United States.
    Catheter Cardiovasc Interv 2017 Oct 9. Epub 2017 Oct 9.
    North Shore University Hospital, Northwell Health System, Department of Internal Medicine, Division of Cardiology, Manhasset, New York, United States.
    Objectives: To assess the in-hospital mortality and complications in female between transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR).

    Background: Female is one of the risk factors for increased adverse events in cardiac surgery.

    Methods And Results: Nationwide Inpatient Sample database was queried from 2011 to 2014 for patients who underwent TAVR or SAVR in female patients. Read More

    Post-TAVR aortogram: Transform it into a modern tool for prognosis and efficiency.
    Catheter Cardiovasc Interv 2017 Oct;90(4):660-661
    Penn State University, College of Medicine, Heart & Vascular Institute, MS Hershey Medical Center, Hershey, Pennsylvania, 17033.
    Video densitometry after aortography can provide objective assessment of aortic regurgitation post-transcatheter aortic valve replacement (TAVR) Contrast density ratio between the left ventricular outflow track and proximal aorta (LVOT-AR) of >0.17 suggests greater than mild aortic insufficiency and correlates with echo findings LVOT-AR of >0.17 is associated with higher 30-day and 1-year mortality. Read More

    Maintenance of valvular integrity with Impella left heart support: Results from the multicenter PROTECT II randomized study.
    Catheter Cardiovasc Interv 2017 Oct 8. Epub 2017 Oct 8.
    Henry Ford Hospital, Detroit, Michigan.
    Background: The Impella 2.5 axial flow pump, which is positioned across the aortic valve, is widely employed for hemodynamic support. The present study compared structural and functional integrity of the left heart valves in patients undergoing Impella vs intra-aortic balloon pump in the randomized PROTECT II trial. Read More

    Long-Term Evaluation of the Ross Procedure in Acute Infective Endocarditis.
    Semin Thorac Cardiovasc Surg 2017 Oct 5. Epub 2017 Oct 5.
    Department of Cardiothoracic and Vascular Surgery, Kepler University Hospital, Linz, Austria; Division of Pediatric Cardiac Surgery, Children's Hospital Linz, Austria.
    Objective: Optimal valve substitute for young patients with aortic valve endocarditis remains controversial. Given its better resistance to infection, the Ross procedure is an attractive alternative to prosthetic valve replacement or homograft implantation. The objective of this study was to assess long-term outcomes of the Ross procedure in this indication. Read More

    Left ventricular outflow tract closure during LVAD implantation: 2 cases of patients supported for over 6 years.
    J Artif Organs 2017 Oct 5. Epub 2017 Oct 5.
    Division of Cardiothoracic Transplant and Assist Devices, Baylor College of Medicine, Houston, TX, USA.
    We previously reported a series of 5 patients with advanced heart failure and aortic insufficiency (AI) who underwent concomitant left ventricular outflow tract (LVOT) closure at the time of continuous-flow left ventricular assist device (CF-LVAD) implantation. Although this technique of treating AI has been shown to be effective in the short term, its long-term durability has not been well studied. Here, we report the long-term outcomes of two patients with severe AI who underwent LVOT closure at the time of CF-LVAD implantation. Read More

    Bentall operation in a patient with an anomalous left circumflex artery: Case report and review.
    J Saudi Heart Assoc 2017 Oct 14;29(4):305-307. Epub 2017 Mar 14.
    Medical Faculty of the Slovak Medical University, National Institute of Cardiovascular Diseases, Clinic of Cardiac Surgery, Bratislava, Slovakia.
    Anomalous origin of a left circumflex artery from the right coronary sinus represents a technical challenge in patients who require aortic valve/root procedures. This case report describes a patient who presented with bicuspid aortic valve, anomalous origin of the circumflex artery, severe aortic regurgitation, and aneurysm of the ascending aorta as well as aortic root that was safely managed following the Bentall procedure with the combined button technique. Read More

    Left side approach for aortic valve replacement in patient with dextrocardia and situs inversus totalis.
    J Saudi Heart Assoc 2017 Oct 24;29(4):297-299. Epub 2017 Mar 24.
    Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
    Aortic valve replacement in patients with dextrocardia and situs inversus totalis is technically challenging due to anatomical considerations. Modifications of the cannulation strategy and operative tool sets are helpful. We report a 47-year-old man who had dextrocardia with situs inversus totalis with severe aortic regurgitation. Read More

    Clinical Outcomes Following the Ross Procedure in Adults: A 25-Year Longitudinal Study.
    J Am Coll Cardiol 2017 Oct;70(15):1890-1899
    Division of Cardiac Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Université Laval, Quebec City, Quebec, Canada. Electronic address:
    Background: Very few reports of long-term outcomes of patients who underwent the Ross procedure have been published.

    Objectives: The authors reviewed their 25-year experience with the Ross procedure with the aim of defining very-long-term survival and factors associated with Ross-related failure.

    Methods: Between January 1990 and December 2014, the Ross procedure was performed in 310 adults (mean age 40. Read More

    Prosthetic mitral inflow mimicking severe aortic regurgitation (revisited). An echocardiographic challenge.
    Echocardiography 2017 Oct;34(10):1500-1502
    Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
    Assessing aortic regurgitation (AR) severity in patients with mitral valve prosthesis may pose an echocardiographic challenge. We present a case of mild AR in whom difficulty occurred in judging its severity due to eccentric mitral prosthetic inflow signals filling practically completely the proximal left ventricular outflow tract in diastole mimicking severe AR. Frame-by-frame analysis of two-dimensional transthoracic echocardiographic images using a small sector depth and width was helpful in clarifying the true severity of AR. Read More

    Isolated aortic root dilation in homocystinuria.
    J Inherit Metab Dis 2017 Oct 4. Epub 2017 Oct 4.
    Charles Dent Metabolic Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
    Background: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta.

    Methods: We conducted a cross-sectional study of patients with homocystinuria, known to a single metabolic centre, and evaluated in 2016 with a transthoracic echocardiogram. Aortic root dilation was defined as Z-score ≥ 2. Read More

    [Approach to aortic aortic valve diseases in the elderly].
    Turk Kardiyol Dern Ars 2017 Sep;45(Suppl 5):47-51
    Department of Cardiology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.
    Aortic valve diseases are the most common among the valvular heart diseases. Significant increases in the frequency of degenerative aortic sclerosis and aortic stenosis (AS) are observed, particularly with aging of the population and diminished rheumatic heart disease. Aortic regurgitation (AR) is less common in the elderly and is accompanied by AS rather than pure AR. Read More

    Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the PARTNER Trial.
    JAMA Cardiol 2017 Sep 27. Epub 2017 Sep 27.
    Cleveland Clinic, Cleveland, Ohio.
    Importance: Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined.

    Objective: To determine the midterm hemodynamic performance of balloon-expandable transcatheter heart valves. Read More

    Association of Paravalvular Regurgitation With 1-Year Outcomes After Transcatheter Aortic Valve Replacement With the SAPIEN 3 Valve.
    JAMA Cardiol 2017 Sep 27. Epub 2017 Sep 27.
    Columbia University Medical Center/New York Presbyterian Hospital, New York, New York.
    Importance: Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves.

    Objective: To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve.

    Design, Setting, And Participants: Prespecified analysis of PVR in the Placement of Aortic Transcatheter Valves (PARTNER) II SAPIEN 3 trial, conducted between October 1, 2013, and September 3, 2014. Read More

    Development of quality metrics for ambulatory pediatric cardiology: Transposition of the great arteries after arterial switch operation.
    Congenit Heart Dis 2017 Oct 2. Epub 2017 Oct 2.
    Department of Pediatrics/Division of Pediatric Cardiology, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA.
    Objective: To develop quality metrics (QMs) for the ambulatory care of patients with transposition of the great arteries following arterial switch operation (TGA/ASO).

    Design: Under the auspices of the American College of Cardiology Adult Congenital and Pediatric Cardiology (ACPC) Steering committee, the TGA/ASO team generated candidate QMs related to TGA/ASO ambulatory care. Candidate QMs were submitted to the ACPC Steering Committee and were reviewed for validity and feasibility using individual expert panel member scoring according to the RAND-UCLA methodology. Read More

    Valvular heart disease and anaesthesia.
    Indian J Anaesth 2017 Sep;61(9):721-727
    Department of Cardiac Anaesthesiology, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.
    Valvular heart disease presents as mixed spectrum lesion in healthcare settings in the third-world and developing countries. Rheumatic heart disease still forms the bulk of the aetiopathology of valve lesions. Mitral and aortic valve lesions top the list of valvular pathology. Read More

    Outcomes of persistent pulmonary hypertension following transcatheter aortic valve replacement.
    Heart 2017 Sep 29. Epub 2017 Sep 29.
    Department of Medicine, Division of Cardiovascular Diseases, University of Pittsburgh, UPMC-Heart and Vascular Institute, Pittsburgh, Pennsylvania, USA.
    Objectives: To determine the prevalence and factors associated with persistent pulmonary hypertension (PH) following transcatheter aortic valve replacement (TAVR) and its relationship with long-term mortality.

    Methods: Consecutive patients who underwent TAVR from July 2011 through January 2016 were studied. The prevalence of baseline PH (mean pulmonary artery pressure ≥25 mm Hg on right heart catheterisation) and the prevalence and the predictors of persistent≥moderate PH (pulmonary artery systolic pressure (PASP)>45 mm Hg on 1 month post-TAVR transthoracic Doppler echocardiography) were collected. Read More

    Triad of infective endocarditis, splenic abscess, and septicemia caused by Brucella melitensis.
    J Lab Physicians 2017 Oct-Dec;9(4):340-342
    Department of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
    A 40-year-old farmer from the district of North Karnataka who had received treatment for high fever of 8 days duration was admitted with fever, dyspnea, and poor general condition. Ultrasonography and echocardiogram revealed multiple splenic abscesses, vegetation on atrioventricular valve, aortic regurgitation (Grade I-II), and mitral valve regurgitation (Grade II-III), respectively. Brucella melitensis was detected in blood culture, and high titers of IgM and IgG anti-Brucella antibodies were observed in Brucella specific serological tests. Read More

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