24,645 results match your criteria Aortic Regurgitation


Does Coronary Reimplantation After Neoaortic Reconstruction Increase Aortic Regurgitation?

Pediatr Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatrics, Dong-A University Hospital, Busan, South Korea.

Coronary reimplantation after neoaortic reconstruction (CRANR) in the arterial switch operation (ASO) allows easy selection of accurate coronary transfer sites in the distended neoaorta. However, neoaortic valve injury may occur during coronary reimplantation. We determined whether the CRANR procedure increased the incidence of aortic valve regurgitation (AR) after ASO. Read More

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http://dx.doi.org/10.1007/s00246-019-02075-6DOI Listing
February 2019

Transcatheter Aortic Valve-in-Valve Implantation in Degenerative Rapid Deployment Surgical Bioprosthesis.

EuroIntervention 2019 Feb 19. Epub 2019 Feb 19.

Rabin Medical Center, Petah Tikva, Israel.

Aims: To evaluate transcatheter aortic valve-in-valve implantation performance in rapid deployment (ViVr) vs. conventional (ViVc) surgical heart valve (SHV).

Methods And Results: A multicenter registry was developed as part of the VIVID international registry. Read More

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http://dx.doi.org/10.4244/EIJ-D-18-00752DOI Listing
February 2019

A case of aortic valve leaflet tear and perforations after neocuspidization.

ESC Heart Fail 2019 Feb 18. Epub 2019 Feb 18.

Department of Cardiovascular Surgery, Chiba-Nishi General Hospital, Matsudo, Japan.

Although aortic valve (AV) replacement is a curative procedure for severe aortic stenosis, prosthetic heart valves have many disadvantages and cause serious complications. A new promising surgical procedure-aortic valve neocuspidization (AVNeo)-has recently been developed; it is an original method of AV reconstruction with autologous pericardium. It has been reported to yield excellent medium-term results with respect to durability and complications. Read More

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http://dx.doi.org/10.1002/ehf2.12415DOI Listing
February 2019

New onset aortic regurgitation.

J Anaesthesiol Clin Pharmacol 2018 Oct-Dec;34(4):557-559

Department of Cardiac Anesthesiology, Sir Ganga Ram Hospital, New Delhi, India.

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http://dx.doi.org/10.4103/joacp.JOACP_8_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360907PMC
February 2019

Clinical outcomes of the Lotus Valve in patients with bicuspid aortic valve stenosis: An analysis from the RESPOND study.

Catheter Cardiovasc Interv 2019 Feb 17. Epub 2019 Feb 17.

Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, CE, Rotterdam, The Netherlands.

Aims: Patients with bicuspid valves represent a challenging anatomical subgroup for transcatheter aortic valve implantation (TAVI). This analysis evaluated the clinical outcomes of the fully repositionable and retrievable Lotus Valve System in patients with bicuspid aortic valves enrolled in the RESPOND post-market registry.

Methods And Results: The prospective, open-label RESPOND study enrolled 1,014 patients at 41 centers in Europe, New Zealand, and Latin America, 31 (3. Read More

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http://dx.doi.org/10.1002/ccd.28120DOI Listing
February 2019

Transfemoral transcatheter aortic valve implantation after aortic valve repair with HAART 300 device.

Catheter Cardiovasc Interv 2019 Feb 17. Epub 2019 Feb 17.

Department of Cardiovascular Surgery, Sana-Herzzentrum Cottbus, Cottbus, Germany.

We report the first successful case, to our knowledge, of CoreValve Evolut R (Medtronic, Minneapolis, MN) implantation into a failed HAART 300 aortic annuloplasty device (BioStable Science & Engineering, TX). An 81-year-old man presented with severe symptomatic aortic regurgitation secondary to failure of the 21 mm HAART 300 device, which had been implanted 45 days previously. Transthoracic echocardiography (TTE) revealed grade 3 aortic regurgitation with central jet, without aortic valve stenosis. Read More

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http://dx.doi.org/10.1002/ccd.28129DOI Listing
February 2019

[Infective Endocarditis in Right Ventricle( RV)-Pulmonary Artery( PA) Conduit Late after the Ross Procedure;Report of a Case].

Kyobu Geka 2019 Feb;72(2):156-159

Department of Cardiovascular Surgery, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.

Ross procedure has been found to have a lower incidence of infective endocarditis compared to other aortic replacement procedure using prosthetic valves. We report a case of 25-year-old man who underwent Ross procedure for congenital aortic stenosis and regurgitation when he was 7 years old. He presented with fever and was highly suspected of infective endocarditis. Read More

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February 2019

[Giant Aneurysm of the Left Sinus of Valsalva Accompanied by Left Main Coronary Artery Compression, Myocardial Ischemia, Pericardial Tamponade].

Kyobu Geka 2019 Feb;72(2):99-103

Department of Cardiovascular Surgery, Yokkaichi Municipal Hospital, Yokkaichi, Japan.

Left sinus of Valsalva aneurysm(SVAn)is a very rare clinical entity. We present a 68-year-old female with left SVAn, 5 cm in diameter, compressing the left main coronary artery and causing antero-septal asynergy. She also had massive pericardial effusion, moderate to severe(grade Ⅲ)aortic regurgitation, and mitral regurgitation. Read More

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February 2019

Valve area and the risk of overestimating aortic stenosis.

Heart 2019 Feb 16. Epub 2019 Feb 16.

Department of Cardiology, Hospital General Universitario Gregorio Maranon, Madrid, Spain.

Objective: To obtain reference values of aortic valve area (AVA) in a large population and to infer the risk of overestimating aortic stenosis (AS) when focusing on flow-corrected indices of severity.

Methods: We prospectively measured indices of AS in all consecutive echocardiograms performed in a large referral cardiac imaging laboratory for 1 year. We specifically analysed the distribution of AVA, indexed AVA and velocity ratio (Vratio) in patients with and without AS, the latter defined as the coexistence of valvular outflow obstruction (Vmax ≥2. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314482DOI Listing
February 2019

Ten-year follow-up of unreplaced Valsalva sinuses after aortic valve replacement in bicuspid aortic valve disease.

Arch Cardiovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiovascular Surgery, Georges Pompidou European Hospital, AP-HP, 75015 Paris, France; School of Medicine, Paris Descartes University, Sorbonne Paris Cité, 75006 Paris, France.

Background: Aortopathy is common in patients with bicuspid aortic valve (BAV).

Aim: To evaluate the fate of unreplaced Valsalva sinuses in patients with BAV, 10 years after aortic valve replacement (AVR) with or without replacement of the ascending aorta (RAA).

Methods: We retrospectively reviewed all surgical patients with BAV who were operated on between January 2005 and December 2007. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.11.014DOI Listing
February 2019

Straining for New Prognostic Predictors in Asymptomatic Severe Aortic Regurgitation.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Division of Cardiology, Cook County Health and Hospitals System, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.jcmg.2019.01.004DOI Listing
February 2019

Long-Term Outcomes After Aortic Valve Surgery in Patients With Asymptomatic Chronic Aortic Regurgitation and Preserved LVEF: Impact of Baseline and Follow-Up Global Longitudinal Strain.

JACC Cardiovasc Imaging 2019 Feb 11. Epub 2019 Feb 11.

Valve Center, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: This study sought to determine whether baseline left ventricular global longitudinal strain (LV-GLS) and changes in left ventricular ejection fraction (LVEF) in a subgroup of subjects at post-operative follow-up added prognostic value in patients undergoing aortic valve (AV) surgery.

Background: In patients with chronic severe aortic regurgitation (AR) and preserved LVEF, sensitive markers are needed to decide timing of AV surgery.

Methods: This was an observational study in 865 patients (asymptomatic/mildly symptomatic, 52 ± 15 years of age, 79% men) with ≥3+ chronic AR and preserved LVEF of ≥50% who underwent AV surgery between 2003 and 2015. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.12.021DOI Listing
February 2019

Self-expanding transcatheter aortic valve implantation for degenerated Mitroflow bioprosthesis: Early outcomes.

Int J Cardiol 2019 Feb 1. Epub 2019 Feb 1.

Heart Area, Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; University of Oviedo, Spain.

Background: The aim of this study was to assess the safety and effectiveness of valve in valve (VIV) TAVI with the autoexpandable valve, specifically in patients with failed Mitroflow (MF) bioprosthetic aortic valves.

Methods: Pilot, single center, observational and prospective study that included 45 consecutive patients with symptomatic failed MF bioprosthetic aortic valve, referred for VIV TAVI. The safety primary endpoint was a composite of early events at 30 days, defined by VARC-2 criteria. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.094DOI Listing
February 2019

Cannulation strategies in acute type A dissection repair: A systematic axillary artery approach.

J Thorac Cardiovasc Surg 2018 Dec 19. Epub 2018 Dec 19.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; Aorta Center, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objectives: Consensus regarding initial cannulation site for acute type A dissection repair is lacking. Objectives were to review our experience with systematic initial axillary artery cannulation, characterize patients on the basis of cannulation site, and assess outcomes.

Methods: From January 2000 to January 2017, 775 patients underwent emergency acute type A dissection repair. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.11.137DOI Listing
December 2018

A novel transcatheter aortic valve with a form-fitting anchor for self-alignment: feasibility in a chronic preclinical model.

Interact Cardiovasc Thorac Surg 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiovascular Surgery, German Heart Centre Munich, Munich, Germany.

Objectives: Our goal was to assess the viability of an alternative anchoring design for a transcatheter aortic valve based on a form-fitting principle with a self-expanding nitinol frame to reduce issues related to excess radial force.

Methods: A 26-mm outer diameter prototype of a self-expanding nitinol frame was developed to reduce the amount of necessary radial force by utilizing additional anchoring via protruding arms in each aortic sinus, thus allowing for a form-fitting principle as well as the coaxial self-alignment of the valve inside the native anatomy. The prototype valve was implanted via a transapical approach in the orthotopic position in 2 sheep. Read More

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http://dx.doi.org/10.1093/icvts/ivz005DOI Listing
February 2019

Graded murine wire-induced aortic valve stenosis model mimics human functional and morphological disease phenotype.

Clin Res Cardiol 2019 Feb 14. Epub 2019 Feb 14.

Cardiovascular Research Laboratory, Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treatments have been identified that can modify disease progression. This unmet medical need is likely attributed to an incomplete understanding of the molecular mechanism driving disease development. Read More

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http://dx.doi.org/10.1007/s00392-019-01413-1DOI Listing
February 2019

[Valve Sparing Aortic Root Replacement].

Authors:
Hitoshi Ogino

Kyobu Geka 2019 Jan;72(1):63-77

Department of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan.

The preservation and repair of the aortic valve, since its valve annulus and leaflets have anatomically complicated 3-dimensional structures, is technically demanding with challenging aspects, and has not been a general surgical treatment, yet. However, in the recent trend of sparing and repair of the native valves in the cardiac surgical field, for aortic root diseases in relatively younger patients, valve sparing aortic root replacement has been attempted with the favorable outcome. In terms of its indication, such technically demanding surgeries had previously been indicated predominantly for patients without any valve deformities and significant aortic valve regurgitation, however in recent years, through the expanding indication with technical advances, they have been performed even for cases with some valve deformities including regurgitant bicuspid aortic valves. Read More

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January 2019

Extracranial and Intracranial Vasculopathy With "Moyamoya Phenomenon" in Association With Alagille Syndrome.

Front Neurol 2018 29;9:1194. Epub 2019 Jan 29.

Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating The National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Alagille syndrome (AGS) is an autosomal-dominant, multisystem disorder caused by mutations in the JAG1 gene. A 34-year-old man was referred to our service 10 years ago with focal seizures with impaired awareness and transient slurred speech. He had a 5-year history of intermittent left monocular low-flow retinopathy. Read More

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http://dx.doi.org/10.3389/fneur.2018.01194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362309PMC
January 2019
1 Read

Bicuspid Aortic Valve: An Update in Morphology, Genetics, Biomarker, Complications, Imaging Diagnosis and Treatment.

Front Physiol 2018 30;9:1921. Epub 2019 Jan 30.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The bicuspid aortic valve, a kind of heart disease that comes from parents, has been paid attention around the world. Although most bicuspid aortic valve (BAV) patients will suffer from some complications including aortic stenosis, aortic regurgitation, endocarditis, and heart dysfunction in the late stage of the disease, there is none symptom in the childhood, which restrains us to diagnose and treatment in the onset phase of BAV. Hemodynamic abnormalities induced by the malformations of the valves in BAV patients for a long time will cause BAV-associated aortopathy: including progress aortic dilation, aneurysm, dissection and rupture, cardiac cyst and even sudden death. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01921
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http://dx.doi.org/10.3389/fphys.2018.01921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363677PMC
January 2019
9 Reads

Cardiac Manifestations in Systemic Lupus Erythematosus: Clinical Correlates of Subclinical Echocardiographic Features.

Biomed Res Int 2019 10;2019:2437105. Epub 2019 Jan 10.

Rheumatology Department, Faculty of Medicine, Cairo University, Giza, Egypt.

Objectives: This study aims to correlate subclinical echocardiographic features with the clinical, laboratory, and therapeutic profiles of the patients to characterize risks for systemic lupus erythematosus (SLE) cardiac diseases.

Methods: The study included 59 SLE patients. Demographic data, disease characteristics, and current therapies were recorded, and the anthropometric measurements and routine laboratory tests were performed. Read More

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http://dx.doi.org/10.1155/2019/2437105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348873PMC
January 2019
1 Read

Use of Intravenous Immunoglobulin Therapy at Unconventional Doses in Refractory Fulminant Systemic Lupus Erythematosus.

Eur J Case Rep Intern Med 2018 27;5(9):000934. Epub 2018 Sep 27.

Rare Diseases and Periodic Fevers Research Centre, Department of Internal Medicine, Agostino Gemelli University Hospital Foundation, Catholic University of the Sacred Heart, Rome, Italy.

The use of human intravenous immunoglobulins (IVIg) in systemic lupus erythematosus (SLE) currently relies on evidence from small case series and is mainly regarded as an off-label strategy in cases that are refractory to conventional therapies or poorly controlled with high doses of corticosteroids. Standard dosage regimens typically entail the administration of a total amount of 2 g/kg of IVIg divided into five consecutive days in order to minimize the risk of severe adverse events. We herein describe the case of a 28-year-old woman with a known history of antiphospholipid syndrome (APS) who was admitted to our hospital following fulminant onset of SLE in spite of ongoing immunosuppressive therapy. Read More

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http://dx.doi.org/10.12890/2018_000934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346821PMC
September 2018

Can complex mitral valve repair be performed with robotics? An institution's experience utilizing a dedicated team approach in 500 patients.

Eur J Cardiothorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Cardiothoracic Surgery, Division of Cardiac Surgery, NYU Langone Health, New York, NY, USA.

Objectives: The full potential of robotics has not been achieved in terms of addressing the most challenging mitral valve (MV) cases. We outline our technique and report our early results with totally endoscopic robotic MV repair in a wide range of pathologies.

Methods: From May 2011 to August 2017, a dedicated team attempted totally endoscopic robotic MV repair in 500 MV regurgitation patients. Read More

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http://dx.doi.org/10.1093/ejcts/ezz029DOI Listing
February 2019
2 Reads

Outcomes of Transcatheter Aortic Valve Implantation in Patients with Cirrhosis.

Int Heart J 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiology, Sakakibara Heart Institute.

Cirrhosis is a significant adverse factor of cardiac surgeries. Transcatheter aortic valve implantation (TAVI) has evolved as a less invasive therapy for aortic stenosis, whereas detailed case analysis of TAVI in cirrhotic patients is limited.Among 444 consecutive patients who underwent TAVI in the Sakakibara Heart Institute between October 2013 and January 2018, we retrospectively reviewed 11 patients (2. Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_18-
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http://dx.doi.org/10.1536/ihj.18-339DOI Listing
February 2019
2 Reads

Concomitant Valve-sparing Aortic Root Replacement with Repair of Tetralogy of Fallot.

Ann Thorac Surg 2019 Feb 8. Epub 2019 Feb 8.

Division of Cardiovascular Surgery. Electronic address:

Valve-sparing aortic root replacement is one of the effective repairs for aortic regurgitation resulting from progressive dilatation of the aortic root late after surgical correction of conotruncal anomaly. However, feasibility and effectiveness of this procedure are unknown for unrepaired physiology. A 32 year-old man presented with unrepaired Tetralogy of Fallot (TOF) and moderate aortic regurgitation with severe left ventricular dysfunction. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.010DOI Listing
February 2019
1 Read

Survival in aortic regurgitation and preoperative ejection fraction.

Ann Thorac Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiovascular Surgery Izmir Katip Celebi University, Ataturk Education and Training Hospital, Karabaglar, Izmir.

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.061DOI Listing
February 2019
1 Read

Bicuspid aortic valve and aortic coarctation in congenital heart disease-important aspects for treatment with focus on aortic vasculopathy.

Cardiovasc Diagn Ther 2018 Dec;8(6):780-788

Department of Cardiac and Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.

Prevalence of congenital heart disease (CHD) is constantly increasing during the last decades in line with the treatment options for patients ranging from the surgical as well to the interventional spectrum. This mini-review addresses two of the most common defects with bicuspid aortic valve (BAV) and coarctation of the aorta (CoA). Both diseases are connected to aortic vasculopathy which is one of the most common reasons for morbidity and mortality in young patients with CHD. Read More

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http://dx.doi.org/10.21037/cdt.2018.09.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331380PMC
December 2018
4 Reads

Cluster analysis of preoperative echocardiographic findings and outcomes following left ventricular device implantation.

J Thorac Cardiovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiac Surgery, University of Michigan Frankel Cardiovascular Center, Ann Arbor, Mich.

Objective: To investigate whether preoperative echocardiography findings determine postoperative continuous-flow left ventricular assist device outcomes.

Methods: From January 2003 to June 2017, 490 patients received a durable, continuous-flow left ventricular assist device. Two-step clustering of parameters including heart rate and preoperative echocardiographic findings (ie, left ventricular [LV] ejection fraction, right ventricular [RV] function, aortic insufficiency, mitral regurgitation [MR], tricuspid regurgitation [TR]) was performed and identified 5 distinct clusters associated with LV failure: group 1: moderate right ventricular dysfunction (RVD), severe MR and mild TR (n = 110); group 2: severe RVD, severe MR and TR (n = 64); group 3: moderate RVD and severe aortic insufficiency (n = 16); group 4: mild RVD and mild valvular pathology (n = 163); and group 5: moderate-severe RVD and mild valvular pathology (n = 137). Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.11.099DOI Listing
December 2018
1 Read

Transcatheter aortic valve replacement for pure aortic valve regurgitation: "on-label" versus "off-label" use of TAVR devices.

Clin Res Cardiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Cardiology, University Heart Center Berlin and Charité University Medicine Berlin, Campus Benjamin-Franklin, Berlin, Germany.

Introduction: Transcatheter aortic valve replacement (TAVR) has become the mainstay of treatment for aortic stenosis in patients with high surgical risk. Pure aortic regurgitation (PAR) is considered a relative contraindication for TAVR; however, TAVR is increasingly performed in PAR patients with unfavorable risk profile. Herein, we aim to summarize available data on TAVR for PAR with special emphasis on "on-label" versus "off-label" TAVR devices. Read More

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http://dx.doi.org/10.1007/s00392-019-01422-0DOI Listing
February 2019
1 Read

Short- and long-term outcomes of aortic root repair and replacement in patients undergoing acute type A aortic dissection repair: Twenty-year experience.

J Thorac Cardiovasc Surg 2018 Dec 21. Epub 2018 Dec 21.

Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.

Objective: The study objective was to evaluate the perioperative and long-term outcomes of aortic root repair and aortic root replacement and provide evidence for root management in acute type A aortic dissection.

Methods: From 1996 to 2017, 491 patients underwent aortic root repair (n = 307) or aortic root replacement (n = 184) (62% bioprosthesis) for acute type A aortic dissection. Indications for aortic root replacement were intimal tear at the aortic root, root measuring 4. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2018.09.129DOI Listing
December 2018
2 Reads

Comprehensive Nursing Management for Valvular Disease.

Authors:
Susan Lee

Crit Care Nurs Clin North Am 2019 Mar 22;31(1):31-38. Epub 2018 Dec 22.

School of Nursing, Louisiana State University Health, 1900 Gravier Street, Room 328, New Orleans, LA 70112, USA. Electronic address:

Valvular heart dysfunction (VHD) affects up to 7% of adults up to age 44 year, whereas up to 13% of individuals older than 75 years are affected. The broad term of valvular heart disease includes dysfunction of one or more of the 4 heart valves, including the pulmonary valve, tricuspid valve, mitral valve, or aortic valve. Specifically the more frequent anomalies, implication, assessment, and treatment that will be described more extensively include aortic regurgitation, aortic stenosis, mitral regurgitation, or tricuspid regurgitation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08995885183100
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http://dx.doi.org/10.1016/j.cnc.2018.11.002DOI Listing
March 2019
3 Reads

Durability of Transcatheter and Surgical Bioprosthetic Aortic Valves in Patients at Lower Surgical Risk.

J Am Coll Cardiol 2019 Feb;73(5):546-553

Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Transcatheter aortic valve replacement (TAVR) is an alternative to surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis and intermediate or high surgical risk.

Objectives: The aim of this study was to compare the durability of transcatheter and surgical bioprosthetic aortic valves using standardized criteria.

Methods: In the NOTION (Nordic Aortic Valve Intervention) trial, all-comer patients with severe aortic stenosis and lower surgical risk for mortality were randomized 1:1 to TAVR (n = 139) or SAVR (n = 135). Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.083DOI Listing
February 2019
1 Read

Long-Term Durability of Transcatheter Aortic Valve Prostheses.

J Am Coll Cardiol 2019 Feb;73(5):537-545

Department of Cardiology, Royal Sussex County Hospital, Brighton, United Kingdom.

Background: Very little is known about long-term valve durability after transcatheter aortic valve replacement (TAVR).

Objectives: This study sought to evaluate the incidence of structural valve degeneration (SVD) 5 to 10 years post-procedure.

Methods: Demographic, procedural, and in-hospital outcome data on patients who underwent TAVR from 2007 to 2011 were obtained from the U. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.10.078DOI Listing
February 2019
2 Reads

Outcomes after Aortic Valve Replacement for Asymptomatic Severe Aortic Regurgitation and Normal Ejection Fraction.

Semin Thorac Cardiovasc Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Electronic address:

Objectives: We investigated long-term outcomes following aortic valve replacement (AVR) in asymptomatic patients with severe aortic regurgitation (AR) and normal left ventricular (LV) function.

Methods: We reviewed 268 patients who underwent isolated AVR for chronic severe AR from 1991-2010 and enrolled 162 asymptomatic patients with normal LV ejection fraction (LVEF) (≥50%) preoperatively. They were divided into 2 groups according to LV dimension at surgery, the early stage C group (indexed LV end-systolic diameter ≤25 mm/m and LV end-diastolic diameter ≤65 mm, n=61), and late stage C group (indexed LV end-systolic diameter >25 mm/m and/or LV end-diastolic diameter >65 mm, n=101). Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.02.005DOI Listing
February 2019
1 Read

Transprosthetic cuff leakage of a bovine pericardial aortic bioprosthesis.

Semin Thorac Cardiovasc Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, Japan.

Objective: The Carpentier-Edwards PERIMOUNT Magna aortic heart valve is the most frequently implanted bioprosthesis. However, the existence of transvalvular cuff leakage necessitating a second cross clamp has been recently reported. The aim of this study is to seek the mechanism, occurrence rate, and influence of cuff leakage on the clinical course. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.02.007DOI Listing
February 2019
1 Read

Cardiac Remodeling in Aortic and Mitral Valve Disease - a Simulation Study with Clinical Validation.

J Appl Physiol (1985) 2019 Feb 7. Epub 2019 Feb 7.

ECMO Department, Karolinska University Hospital, Stockholm, Sweden.

Background: Remodeling is an important long-term determinant of cardiac function throughout the progression of heart disease. Numerous biomolecular pathways for mechanosensing and transduction are involved. However, we hypothesize that biomechanical factors alone can explain changes in myocardial volume and chamber size in valve disease. Read More

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https://www.physiology.org/doi/10.1152/japplphysiol.00791.20
Publisher Site
http://dx.doi.org/10.1152/japplphysiol.00791.2018DOI Listing
February 2019
12 Reads

Association of Structural and Functional Cardiac Changes With Transcatheter Aortic Valve Replacement Outcomes in Patients With Aortic Stenosis.

JAMA Cardiol 2019 Feb 6. Epub 2019 Feb 6.

Division of Cardiovascular Diseases, Department of Internal Medicine, Heart & Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Importance: Severe aortic stenosis causes pressure overload of the left ventricle, resulting in progressive cardiac dysfunction that can extend beyond the left ventricle. A staging system for aortic stenosis has been recently proposed that quantifies the extent of structural and functional cardiac changes in aortic stenosis.

Objectives: To confirm the reproducibility of a proposed staging system and expand the study findings by performing a survival analysis and to evaluate the association of aortic stenosis staging with both cardiac and noncardiac post-transcatheter aortic valve replacement (TAVR) readmissions. Read More

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http://dx.doi.org/10.1001/jamacardio.2018.4830DOI Listing
February 2019
1 Read

Comparison of transcatheter aortic valve implantation with other approaches to treat aortic valve stenosis: a systematic review and meta-analysis.

Syst Rev 2019 Feb 5;8(1):44. Epub 2019 Feb 5.

Department of Internal Medicine 3, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Dunant-Platz 1, 3100, St. Poelten, Austria.

Background: Transcatheter aortic valve replacement (TAVI) is an alternative treatment for patients with symptomatic severe aortic stenosis ineligible for surgical aortic valve replacement (SAVR) or at increased perioperative risk. Due to continually emerging evidence, we performed a systematic review and meta-analysis comparing benefits and harms of TAVI, SAVR, medical therapy, and balloon aortic valvuloplasty.

Methods: We searched MEDLINE, Embase, and Cochrane CENTRAL from 2002 to June 6, 2017. Read More

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http://dx.doi.org/10.1186/s13643-019-0954-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362570PMC
February 2019
2 Reads

TAVR for aortic valve regurgitation: Ready for a randomized trial?

Catheter Cardiovasc Interv 2019 Feb;93(2):354-355

Department of Interventional Cardiology and Endovascular Therapeutics, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.

Transcatheter aortic valve replacement has been used successfully to treat native aortic valve regurgitation. Current observational evidence shows promising results in terms of procedural success while outcome data are difficult to interpret given the observational nature of the evidence. We are ready for a randomized trial, which will be very challenging to run. Read More

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http://dx.doi.org/10.1002/ccd.28079DOI Listing
February 2019
2 Reads

Left Atrial Dysfunction as an Independent Correlate of Heart Failure Symptoms in Patients With Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction.

J Am Soc Echocardiogr 2019 Feb;32(2):257-266

University of Medicine and Pharmacy "Carol Davila," Euroecolab, Bucharest, Romania; Emergency Institute of Cardiovascular Diseases "Prof. Dr. C. C. Iliescu", Bucharest, Romania. Electronic address:

Background: Data regarding the contribution of left atrial (LA) dysfunction to the occurrence of heart failure in patients with severe aortic stenosis (AS) are scarce. The aim of this study was to assess the relationship between LA deformation and symptomatic status in this clinical setting.

Methods: A total of 361 consecutive patients with severe AS (aortic valve area [AVA] index ≤ 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08947317183064
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http://dx.doi.org/10.1016/j.echo.2018.11.007DOI Listing
February 2019
7 Reads

Bicuspid aortic valve behaviour in elite athletes.

Eur Heart J Cardiovasc Imaging 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, Hospital Universitario Fundación Jiménez Díaz, Av. de los Reyes Católicos, 2, 28040 Madrid, Spain.

Aims: To determine the prevalence and characteristics of bicuspid aortic valve (BAV) among elite athletes and to analyse the effect of long-term exercise training on their aortas.

Methods And Results: Consecutive BAV and tricuspid aortic valve (TAV) elite athletes from a population of 5136 athletes evaluated at the Sports Medicine Center of the Spanish National Sports Council were identified using echocardiography. A total of 41 BAV elite athletes were matched with 41 TAV elite athletes, and 41 BAV non-athletic patients from three Spanish tertiary hospitals. Read More

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http://dx.doi.org/10.1093/ehjci/jez001DOI Listing
January 2019
3 Reads
3.669 Impact Factor

Elevated diastolic wall shear stress in regurgitant semilunar valvular lesions.

J Magn Reson Imaging 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology and Congenital Heart Disease, German Heart Center at Technical University of Munich, Munich, Germany.

Background: Alterations in wall shear stress (WSS) assessed using 4D flow MRI have been shown to play a role in various vascular pathologies, such as bicuspid aortic valve aortopathy. Most studies have focused on systolic WSS, whereas altered diastolic hemodynamics in regurgitant semilunar valvular lesions have not so far been well characterized.

Purpose: To investigate diastolic WSS in aortic and pulmonary regurgitation. Read More

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http://dx.doi.org/10.1002/jmri.26680DOI Listing
February 2019
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Impact of predilation before transcatheter aortic valve implantation with new-generation devices.

Cardiovasc Revasc Med 2019 Jan 23. Epub 2019 Jan 23.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; IRCCS NEUROMED, Pozzilli, Italy. Electronic address:

Background: Significant aortic stenosis can be effectively treated with transcatheter aortic valve implantation (TAVI) in patients at high or intermediate surgical risk. Predilation is often performed to facilitate TAVI implantation, but its risk-benefit balance with new-generation devices is detabed. We aimed to appraise whether predilation is still needed with new-generation devices for TAVI. Read More

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http://dx.doi.org/10.1016/j.carrev.2019.01.017DOI Listing
January 2019
1 Read

Five-Year Clinical and Echocardiographic Outcomes from the Nordic Aortic Valve Intervention (NOTION) Randomized Clinical Trial in Lower Surgical Risk Patients.

Circulation 2019 Feb 1. Epub 2019 Feb 1.

Cardiology, Rigshospitalet, Denmark.

Background: The Nordic Aortic Valve Intervention (NOTION) was designed to compare transcatheter aortic valve replacement (TAVR) to surgical aortic valve replacement (SAVR) in patients 70 years or older with isolated severe aortic valve stenosis. Clinical and echocardiographic outcomes are presented after 5 years.

Methods: Patients were enrolled at three Nordic centers and randomized 1:1 to TAVR using the self-expanding CoreValve prosthesis (n=145) or SAVR using any stented bio-prostheses (n=135). Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036606DOI Listing
February 2019
2 Reads

Simplified Echocardiography Screening Criteria for Diagnosing and Predicting Progression of Latent Rheumatic Heart Disease.

Circ Cardiovasc Imaging 2019 Feb;12(2):e007928

The Heart Institute, Cincinnati Children's Hospital Medical Center, OH (A.Z.B.).

Background: The 2012 World Heart Federation Criteria are the current gold standard for the diagnosis of latent rheumatic heart disease (RHD). Because data and experience using these criteria have grown, there is opportunity to simplify and develop outcome prediction tools. We aimed to develop a simple echocardiographic score applicable for RHD screening with potential to predict disease progression. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.007928DOI Listing
February 2019
1 Read

Clinical Outcomes of Transcatheter Aortic Valve Implantation in Patients With Extremely Large Annulus and SAPIEN 3 Dimensions Based on Post-Procedural Computed Tomography.

Circ J 2019 Jan 30. Epub 2019 Jan 30.

Cedars-Sinai Medical Center, Heart Institute.

Background: Patients with severe aortic stenosis (AS) and an extra-large annulus (ELA) area (>683 mm) can rarely be treated by transcatheter aortic valve replacement (TAVR) because of the size limitation of the transcatheter heart valves. This study aimed to evaluate the feasibility of TAVR using a 29-mm SAPIEN3 (S3) valve in patients with ELA and S3-dimensions by post-procedural computed tomography (post-CT). Methods and Results: We included 261 patients undergoing TAVR using a 29-mm S3: 30 patients with ELA and 231 with non-ELA were identified. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-1059DOI Listing
January 2019
2 Reads

[Clinical analysis of transcatheter closure of ventricular septal defect with right coronary cusp bulge].

Zhonghua Er Ke Za Zhi 2019 Feb;57(2):103-107

Department of Cardiology, Shanghai Children's Medical Center, Shanghai JiaoTong University School of Medicine, Shanghai 200127, China.

To access the feasibility, effectiveness and safety of transcatheter closure of ventricular septal defect (VSD) with right coronary cusp bulge. The study population consisted of 40 children (22 boys and 18 girls) undergoing transcatheter intervention for VSD with right coronary cusp bulge in Shanghai Children's Medical Center from August 2013 to June 2017. All patients were examined using transthoracic echocardiography and cardiovascular angiography before occlusion and received transcatheter closure of VSD by placing an occlude. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.02.008DOI Listing
February 2019
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Excessive pannus overgrowth on the aortic side of Trifecta valve determining severe regurgitation.

Ann Thorac Surg 2019 Jan 23. Epub 2019 Jan 23.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Structural valve deterioration represents the most important concern regarding the implantation of a biological heart valve in young patients. Several strategies have been proposed to improve prosthesis design in order to optimize performance and durability. Here we describe an early and specific mode for valve degeneration of prosthesis with outwards mounted pericardial leaflets due to pannus overgrowth on the aortic side. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.12.036DOI Listing
January 2019
2 Reads

Evaluation of relationship between bicuspid aortic valve phenotype with valve dysfunction and associated aortopathy.

J Cardiovasc Thorac Res 2018 13;10(4):236-242. Epub 2018 Dec 13.

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Morphology of bicuspid aortic valve (BAV) may have implication in the associated pathologies including aortic stenosis (AS), aortic insufficiency (AI) and aortic dilation. The aim of this study is to investigate the frequency and patterns of valvular dysfunction and aortopathy associated with different phenotypes of BAV in a referral center in northwest of Iran. In this prospective study patients who presented to our echocardiography lab between January 2014 and December 2015 and were diagnosed with BAV were assessed. Read More

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http://dx.doi.org/10.15171/jcvtr.2018.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335981PMC
December 2018
1 Read

Surface biofunctionalization of the decellularized porcine aortic valve with VEGF-loaded nanoparticles for accelerating endothelialization.

Mater Sci Eng C Mater Biol Appl 2019 Apr 26;97:632-643. Epub 2018 Dec 26.

Department of cardiovascular surgery, the Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.

The original intention for building a tissue-engineered heart valve (TEHV) was to simulate a normal heart valve and overcome the insufficiency of the commonly used heart valve replacement in the clinic. The endothelialization of the TEHV is very important as the endothelialized TEHV can decrease platelet adhesion and delay the valvular calcification decline process. In this work, we encapsulated vascular endothelial growth factor (VEGF) into polycaprolactone (PCL) nanoparticles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09284931183236
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http://dx.doi.org/10.1016/j.msec.2018.12.079DOI Listing
April 2019
4 Reads