27,322 results match your criteria Aortic Regurgitation


Prognosis of functional mitral regurgitation after aortic valve replacement for pure severe aortic stenosis.

J Card Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of Cardiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, Québec, Canada.

Objective: Whether patients with severe aortic stenosis (AS) and significant functional mitral regurgitation (MR) should undergo isolated aortic (aortic valve replacement [AVR]) or double aortic-mitral valve procedure (DVP) remains controversial. We sought to determine outcomes of such patients undergoing surgical (surgical aortic valve replacement [SAVR]) and transcatheter AVR (TAVR) or DVP, identify echocardiographic parameters predictive of significant residual MR after isolated AVR, and determine its impact on long-term survival.

Methods: Data prospectively collected from 736 consecutive patients with severe AS and significant MR undergoing AVR or DVP were retrospectively analyzed. Read More

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Hospital outcome of concomitant tricuspid annuloplasty during totally endoscopic mitral valve surgery: a propensity matched study.

J Thorac Dis 2021 May;13(5):3042-3050

Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, China.

Background: This study aimed to determine how concomitant tricuspid annuloplasty (TAP) affects the clinical outcomes of patients undergoing totally endoscopic mitral valve surgery.

Methods: This was a single-centre, retrospective study. Between January 2019 and June 2020, 143 patients who underwent totally endoscopic mitral valve surgery in our institution were enrolled. Read More

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Ventricular septal defect closure using radial incision of the tricuspid valve for exposure: is it really necessary?

Cardiovasc J Afr 2021 Jun 22;32:1-5. Epub 2021 Jun 22.

Department of Pediatric Cardiac Surgery, Saglik Bilimleri University, Dr Behcet Uz Children's Training and Research Hospital, Izmir, Turkey.

Aim: To evaluate the effects of radial incision of the tricuspid valve in patients who had undergone ventricular septal defect (VSD) closure.

Methods: Overall 173 patients were included in this study between 2012 and 2019. In 44 individuals, a tricuspid valve radial incision (TVRI) was included in the surgical process. Read More

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Exercise physiology in left ventricular assist device patients: insights from hemodynamic simulations.

Ann Cardiothorac Surg 2021 May;10(3):339-352

Department of Cardiovascular Sciences, Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.

Left ventricular assist devices (LVADs) assure longer survival to patients, but exercise capacity is limited compared to normal values. Overall, LVAD patients show high wedge pressure and low cardiac output during maximal exercise, a phenomenon hinting at the need for increased LVAD support. Clinical studies investigating the hemodynamic benefits of an LVAD speed increase during exercise, ended in inhomogeneous and sometimes contradictory results. Read More

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Transcatheter Treatment of Valvular Heart Disease: A Review.

JAMA 2021 Jun;325(24):2480-2494

Bluhm Cardiovascular Institute and Departments of Medicine and Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Importance: More than 40 million people are living with either mitral or aortic valve disease worldwide, and more than 180 000 heart valve replacement surgeries are performed each year in the US. Transcatheter valve repair has emerged as an important therapeutic option for patients who are candidates for heart valve replacement.

Observations: All transcatheter valve therapies involve a multidisciplinary team of interventional cardiologists, cardiothoracic surgeons, radiologists, echocardiographers, nurses, and social workers, termed the heart team, to determine the optimal approach for managing each patient. Read More

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Infective endocarditis by a rare and fastidious agent: .

BMJ Case Rep 2021 Jun 21;14(6). Epub 2021 Jun 21.

Cardiology, Hospital de Braga, Braga, Portugal.

is a nutritional variant streptococcus, with affinity for endovascular structures that cannot be cultured on non-supplemented media, leading to a delay in diagnosis. This case describes a 36-year-old woman with a previously known bicuspid aortic valve that presented with asthenia, myalgias and anorexia with 2-month onset. On admission, we documented fever and a systolic murmur. Read More

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Case Report: Disappearance of Coronary Anastomotic Aneurysm by Steroid Therapy in Takayasu Arteritis: Pseudorepair of Pseudoaneurysm?

Front Cardiovasc Med 2021 4;8:683216. Epub 2021 Jun 4.

Department of Cardiovascular Surgery, Sapporo, Japan.

Takayasu arteritis (TA) is a large vessel vasculitis of unknown etiology characterized by chronic inflammatory changes of the aorta and its major branches. Complications such as anastomotic aneurysm and valve detachment have been reported in active TA patients who received aortic valve replacement and graft replacement of aorta. A 61-year-old man with a history of emergency aortic valve replacement and patch closure of the noncoronary sinus of Valsalva due to acute heart failure induced by acute aortic regurgitation and ruptured sinus of Valsalva 4 years ago was referred for exertional dyspnea. Read More

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Critical Limb Ischemia in a Young Patient With a Mechanical Aortic Valve Leading to Bilateral Above-Knee Amputation.

Cureus 2021 May 15;13(5):e15046. Epub 2021 May 15.

Department of Internal Medicine, Medical Center of Trinity, Trinity, USA.

This case reports a 24-year-old female with prior aortic insufficiency who underwent a mechanical aortic valve replacement with subsequent transient ischemic attacks and documented subtherapeutic international normalized ratio (INR). She presented with pain and bilateral lower extremity pulselessness. Workup showed a supratherapeutic INR, no thrombus on echocardiogram, and computed tomography angiography demonstrating no flow in the bilateral common femoral arteries. Read More

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A study of the clinical application value of ultrasound and electrocardiogram in the differential diagnosis of cardiomyopathy.

Am J Transl Res 2021 15;13(5):5200-5207. Epub 2021 May 15.

Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University Haikou 570102, Hainan, China.

Objective: To investigate the clinical application values of electrocardiogram (ECG) combined with ultrasound cardiogram (UCG) in the differential diagnosis of cardiomyopathy.

Methods: A total of 120 patients with cardiomyopathy who were admitted to our hospital were randomly divided into the dilated cardiomyopathy (DCM) group (60 cases) and the ischemic cardiomyopathy (ICM) group (60 cases). Both groups were examined using ECG combined with UCG. Read More

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Aortic valve replacement for dextrocardia with situs inversus totalis.

J Card Surg 2021 Jun 20. Epub 2021 Jun 20.

Department of Cardiovascular Surgery, St. Mary's Hospital, Kurume, Japan.

Dextrocardia is a rare congenital cardiac positional anomaly. A 74-year-old woman was referred for aortic regurgitation (AR). Chest X-ray revealed a mildly enlarged heart that directed to the right side. Read More

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The ACURATE neo2 valve system for transcatheter aortic valve implantation: 30-day and 1-year outcomes.

Clin Res Cardiol 2021 Jun 20. Epub 2021 Jun 20.

Department of Cardiology/Cardiac Surgery, Kerckhoff Heart Centre, Bad Nauheim, Germany.

Background: Transcatheter aortic valve implantation (TAVI) has become standard treatment for elderly patients with symptomatic severe aortic valve stenosis. The ACURATE neo AS study evaluates 30-day and 1-year clinical and hemodynamic outcomes in patients treated with the ACURATE neo2 valve.

Methods: The primary endpoint of this single-arm multicenter study is 30-day all-cause mortality. Read More

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Operator preference and determinants of size selection when additional intermediate-size aortic transcatheter heart valves are made available.

Int J Cardiol 2021 Jun 17. Epub 2021 Jun 17.

Department of Cardiology, National University of Ireland, Galway (NUIG), Galway, Ireland.

Background: Appropriate size selection of transcatheter heart valves (THVs) is fundamental to reduce transcatheter aortic valve implantation (TAVI) related complications, particularly paravalvular aortic regurgitation, new permanent pacemaker implantation, and annular rupture. We sought to investigate the frequency of operator selection of intermediate-size balloon-expandable Myval THVs (Meril Life Sciences Pvt. Ltd. Read More

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A Pseudocoarctation of the Aorta With a Left Subclavian Artery Aneurysm, A Case Report and A Review of the Literature.

Vasc Endovascular Surg 2021 Jun 18:15385744211022536. Epub 2021 Jun 18.

Department of Cardiovascular Surgery, Kocaeli University Medical Faculty, Kocaeli, Turkey.

Here we present a 47-year-old male diagnosed with a pseudocoarctation of the aorta and a funnel-like subclavian artery aneurysm with a large orifice and severe aortic valve insufficiency. The patient underwent a two-stage repair for both pathologies. After an aortic valve replacement, postcardiotomy pericardial effusion occurred and was medically managed. Read More

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Impact of Predilation During Transcatheter Aortic Valve Replacement: Insights From the PARTNER 3 Trial.

Circ Cardiovasc Interv 2021 Jun 18:CIRCINTERVENTIONS120010336. Epub 2021 Jun 18.

Department of Cardiology, Baylor Scott and White, The Heart Hospital Plano, TX (K.A.-A., M.S., S.P., M.H., M.J.M.).

Background: The use of predilation during transcatheter aortic valve replacement (TAVR) is variable, and its association with outcomes remains unknown. We evaluated the impact of predilation versus no predilation (direct TAVR) in the low-risk population enrolled in the PARTNER 3 trial (Placement of Aortic Transcatheter Valves).

Methods: In the PARTNER 3 trial, 495 patients with severe symptomatic aortic stenosis underwent TAVR with the SAPIEN 3 valve. Read More

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Patient-Specific Computational Fluid Dynamics Reveal Localized Flow Patterns Predictive of Post-Left Ventricular Assist Device Aortic Incompetence.

Circ Heart Fail 2021 Jun 18:CIRCHEARTFAILURE120008034. Epub 2021 Jun 18.

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford University School of Medicine. (R.S., S.K., R.F., N.Q., C.B., P.K., Y.S., J.T., Y.J.W., W.H.).

Background: Progressive aortic valve disease has remained a persistent cause of concern in patients with left ventricular assist devices. Aortic incompetence (AI) is a known predictor of both mortality and readmissions in this patient population and remains a challenging clinical problem.

Methods: Ten left ventricular assist device patients with de novo aortic regurgitation and 19 control left ventricular assist device patients were identified. Read More

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The Allegra transcatheter heart valve: Short term results from a multicenter registry.

Catheter Cardiovasc Interv 2021 Jun 17. Epub 2021 Jun 17.

Heart Center Lucerne, Luzerner Kantonsspital, Lucerne, Switzerland.

Objectives: We aimed to determine the safety and efficacy of the Allegra transcatheter heart valve (THV) for the treatment of severe aortic valve stenosis in a large patient population treated under real-world conditions.

Background: The Allegra is a novel self-expanding THV with supra-annular bovine leaflets. The valve is available in three different sizes (23, 27, and 31 mm), all are delivered through an 18F sheath. Read More

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Left Ventricular Hypertrophic Change Indicating Poor Prognosis in Patients With Normal-Flow, Low-Gradient Severe Aortic Stenosis With Preserved Left Ventricular Ejection Fraction.

Circ Rep 2021 May 26;3(6):345-353. Epub 2021 May 26.

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences Nagoya Japan.

Risk stratification of normal-flow, low-gradient (NFLG) severe aortic stenosis (SAS) with preserved left ventricular (LV) ejection fraction (EF) remains unclear. Of 289 consecutive patients diagnosed with SAS by aortic valve area <1.0 cm, 66 with NFLG-SAS (stroke volume index >35 mL/m, mean pressure gradient <40 mmHg, LVEF ≥50%) were enrolled in this study; patients with bicuspid aortic valve, acute coronary syndrome, hemodialysis, or a history of aortic valve replacement (AVR) were excluded. Read More

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Pseudoaneurysm of the mitral-aortic intervalvular fibrosa with fistulous communication to the left atrium causing congestive heart failure.

Clin Case Rep 2021 Jun 10;9(6):e04301. Epub 2021 Jun 10.

Icahn School of Medicine at Mount Sinai New York NY USA.

Pseudoaneurysms of the mitral-aortic intervalvular fibrosa can rupture and form fistulous communications between the left ventricle and left atrium. Pulmonary venous systolic flow reversal in such cases reflects elevated left atrial pressure due to shunting. This finding, particularly in the setting of endocarditis, is not specific for severe mitral regurgitation. Read More

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Mitral Regurgitation and Transcatheter Aortic Valve Replacement: Are There Any Other Prognostic Implications?

Arq Bras Cardiol 2021 Jun;116(6):1070-1071

Universidade de São Paulo Instituto do Coração - Unidade Clinica de Valvopatia , São Paulo , SP - Brasil.

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Relationship between Mitral Regurgitation and Transcatheter Aortic Valve Implantation: a Multi-Institutional Follow-up Study.

Arq Bras Cardiol 2021 Jun;116(6):1059-1069

Universidade de São Paulo Instituto do Coração , São Paulo , SP - Brasil.

Background: Mitral regurgitation (MR) is prevalent in patients undergoing transcatheter aortic valve implantation (TAVI). There are some controversies about the prognostic impact of MR in survival of TAVI patients.

Objective: To examine the relationship between TAVI and MR in a patient population from the Brazilian TAVI Registry. Read More

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Transcatheter pulmonic valve implantation: Techniques, current roles, and future implications.

World J Cardiol 2021 May;13(5):117-129

Division of Cardiology, University of Arizona College of Medicine, Tuscon, AZ 85724, United States.

Right ventricular outflow tract (RVOT) obstruction is present in a variety of congenital heart disease states including tetralogy of Fallot, pulmonary atresia/stenosis and other conotruncal abnormalities After surgical repair, these patients develop RVOT residual abnormalities of pulmonic stenosis and/or insufficiency of their native outflow tract or right ventricle to pulmonary artery conduit. There are also sequelae of other surgeries like the Ross operation for aortic valve disease that lead to right ventricle to pulmonary artery conduit dysfunction. Surgical pulmonic valve replacement (SPVR) has been the mainstay for these patients and is considered standard of care. Read More

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Incidence, Predictors, and Prognostic Impact of Immediate Improvement in Left Ventricular Systolic Function After Transcatheter Aortic Valve Implantation.

Am J Cardiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Immediate improvement in left ventricular ejection fraction (LVEF) following transcatheter aortic valve implantation (TAVI) is common; however, data on the pattern and prognostic value of this improvement are limited. To evaluate the incidence, predictors, and clinical impact of immediate improvement in LVEF, we studied 694 consecutive patient who had underwent successful TAVI for severe aortic stenosis (AS) between March 2010 and December 2019. We defined immediate improvement of LVEF as an absolute increase of ≥5% in LVEF at post-procedure echocardiogram. Read More

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[Clinical application value of transthoracic echocardiography during perioperative period in patients undergoing left ventricular assist device implantation].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):610-614

Adult Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.

To observe the changes of parameters derived from transthoracic echocardiography (TTE) before and after left ventricular assist device (LVAD) implantation, and to evaluate the clinical value of TTE in the perioperative period of LVAD implantation. This is a retrospective study. The data of patients who underwent LVAD implantation in Fuwai Hospital from January 2018 to December 2020 were analyzed retrospectively. Read More

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Polish Multicenter Registry (Pol-LAS-SE registry). Stress echocardiography in low-gradient aortic stenosis in Poland: numbers, settings, results, complications and clinical practice.

Kardiol Pol 2021 ;79(5):517-524

Department of Cardiology, Wroclaw Medical University, Wrocław, Poland.

Background: The diagnostic workup of low-gradient aortic stenosis (LG AS) is a challenge in clinical practice.

Aims: Our goal was to assess the diagnostic value of stress echocardiography (SE) performed in patients with undefined LG AS with low and preserved ejection fraction (EF) and the impact of its result on therapeutic decisions in Polish third level of reference.

Methods: All the patients with LG AS and with SE performed were recruited in 16 Polish cardiology departments between 2016 and 2019. Read More

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Dobutamine stress echocardiography in low-flow, low-gradient aortic stenosis with concomitant severe functional mitral regurgitation: a case report.

Eur Heart J Case Rep 2021 May 17;5(5):ytab150. Epub 2021 May 17.

Department of Cardiovascular Medicine, Kokura Memorial Hospital, 3-2-1 Asano, Kokurakita-ku, Kitakyushu, Fukuoka 802-8555, Japan.

Background : Dobutamine stress echocardiography (DSE) in classical low-flow, low-gradient (LFLG) aortic stenosis (AS) is recommended in recent guidelines to differentiate true-severe AS from pseudo-severe AS. However, DSE for patients with concomitant significant mitral regurgitation (MR) is often inaccurate or inconclusive.

Case Summary : A 73-year-old man with a history of coronary artery bypass grafting was referred to our institution with congestive heart failure. Read More

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A case report of cardiogenic shock from takotsubo cardiomyopathy with left ventricular outflow tract obstruction: fundamental lessons in cardiac pathophysiology.

Eur Heart J Case Rep 2021 Apr 21;5(4):ytab127. Epub 2021 Apr 21.

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, San Diego, 9452 Medical Center Drive #7411 La Jolla, CA 92037-7411, USA.

Background: A subset of patients with takotsubo cardiomyopathy will develop significant dynamic left ventricular outflow tract (LVOT) obstruction leading to cardiogenic shock. However, traditional therapies for cardiogenic shock that focus on increased inotropy and afterload reduction can be detrimental in this situation.

Case Summary: We describe a 71-year-old woman who presented to the emergency department with typical, substernal chest pain found to be hypotensive with ST-elevations in the lateral leads. Read More

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Survival of patients with mild secondary mitral regurgitation with and without mild tricuspid regurgitation.

Can J Cardiol 2021 Jun 10. Epub 2021 Jun 10.

Divison of Cardiac Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address:

Background: Mild secondary mitral regurgitation (SMR) is considered clinically benign when left ventricular ejection fraction (LVEF) is preserved, but evidence on survival associated with mild SMR in normal LVEF is limited.

Methods: We conducted a retrospective cohort study of patients who underwent echocardiogram in a healthcare network between 2013 and 2018. We compared the survival of 4 groups: no valvular abnormalities (group 1), trace SMR with trace or mild TR (group 2), mild SMR with trace or no TR (group 3), and mild SMR with mild TR (group 4). Read More

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Mechanical Circulatory Support for the Failing Sub-Aortic Right Ventricle in Adults.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:2-9

Texas Children's Hospital Heart Center, Texas Children's Hospital and Department of Surgery, Baylor College of Medicine, Houston, Texas. Electronic address:

Patients with ccTGA or d-TGA managed via atrial switch (Mustard or Senning operations) have biventricular circulations with a sub-aortic right ventricle (2V-RV). Other than in a tiny percentage of ccTGA patients, premature heart failure (HF) is common, driven by chronic RV dilatation and dysfunction and/or tricuspid regurgitation. These patients are different from the general HF population in that they are younger, more heterogeneous, are predisposed to pulmonary hypertension and present unique and complex surgical challenges. Read More

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January 2021

Simultaneous transcatheter treatment of ascending aortic aneurysm with aortic and mitral regurgitation: an in vitro study.

Interact Cardiovasc Thorac Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China.

Objectives: We sought to explore the efficacy of the endovascular repair of an ascending aortic aneurysm with aortic and mitral regurgitation by 2 novel valved stents.

Methods: We established models of ascending aortic aneurysms combined with aortic and mitral regurgitation in 10 pig hearts, then implanted self-expanding aortic fenestrated and mitral valved stents via the transapical approach. We applied a fluoroscopy-guided in vitro setting to test the approach, then analysed continuous circulating flushing at 37°C. Read More

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Traumatic aortic root rupture leading to acute aortic regurgitation and acute type A aortic dissection.

Echocardiography 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiology, SUNY Upstate Medical University, Syracuse, NY, USA.

A 17-year-old male sustained a blunt thoracic trauma after he had a dirt bike accident. He was admitted for the management of multiple fractures, was hemodynamically stable, and presented without any cardiac symptoms. The patient underwent transthoracic echocardiography and CT angiogram of the thorax as the workup of possible cardiac injury as he had a new aortic regurgitation murmur, troponin rise, and a new RBBB. Read More

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