Search Our Scientific Publications & Authors

J Card Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Cardiac, Thoracic and Vascular Sciences, Section of Pediatric and Congenital Cardiac Surgery, Medical School, University of Padua, Padua, Italy.

Background: To evaluate early and long-term results of surgical treatment of aortic coarctation (CoAo) in infants and children.

Methods: A retrospective clinical review of patients less than 18 years with CoAo, undergoing surgery between 1995 and 2015. Data were retrieved from our institutional database, to identify preoperative and postoperative characteristics. Read More

PPAR Res 2019 3;2019:1371758. Epub 2019 Feb 3.

Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico.

Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPAR) ligand, has been reported to act as insulin sensitizer and exert cardiovascular actions. In this work, we hypothesized that RGZ exerts a PPAR-dependent regulation of blood pressure through modulation of angiotensin-converting enzyme (ACE)-type 2 (ACE2)/angiotensin-(1-7)/angiotensin II type-2 receptor (ATR) axis in an experimental model of high blood pressure. We carried on experiments in normotensive (Sham) and aortic coarctation (AoCo)-induced hypertensive male Wistar rats. Read More

Children (Basel) 2019 Mar 8;6(3). Epub 2019 Mar 8.

McGovern Medical School, University of Texas-Houston, Children's Memorial Hermann Hospital, Houston, TX 77030, USA.

Since the description of surgery for patent ductus arteriosus in late 1930s, an innumerable number of advances have taken place in the management of congenital heart defects (CHDs). In this review the current status of treatment of seven of the most common acyanotic CHDs was reviewed. The discussion included indications for, and timing of, intervention and methods of intervention. Read More

Mol Genet Genomic Med 2019 Mar 4:e612. Epub 2019 Mar 4.

Histology Department, Benha Faculty of Medicine, Benha University, Benha, Egypt.

Background: Several genes encoding transcription factors are known to be the primary cause of congenital heart disease. NKX2-5 and GATA4 were the first congenital heart disease-causing genes identified by linkage analysis. This study designed to study the association of five single-nucleotide variants of NKX2-5, GATA4, and TBX5 genes with sporadic nonsyndromic cases of a congenital cardiac septal defect in Egyptian children. Read More

Ann Thorac Surg 2019 Mar 1. Epub 2019 Mar 1.

Department of Surgery and Clinical Science, Division of Cardiac Surgery.

Georgian Med News 2019 Jan(286):7-13

A.N Bakulev National Medical Reseach Center for Cardiovascular Surgery, Ministry of Health of Russian Federation, MoscowRussian Federation.

The goal of the research was to elaborate a model for prognosticating the probability of the development of long-term coronogenic complications after the arterial switch operation. A single-center retrospective cohort study of the outcomes of treating 248 patients with TGA has been conducted. All the patients underwent an AS operation at the clinic of Bakulev National Medical Research Center of Cardiovascular Surgery. Read More

Eur Heart J 2019 Feb 25. Epub 2019 Feb 25.

Department of Cardiovascular Surgery, University Hospital Zürich, Rämistrasse 100, Zurich, Switzerland.

World J Pediatr Congenit Heart Surg 2019 01;10(1):72-80

3 Division of Pediatric Cardiology, Children's Healthcare of Atlanta-Emory University, Atlanta, GA, USA.

The IMproving Pediatric and Adult Congenital Treatments (IMPACT) Registry and the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) are two efforts initiated to improve outcomes in the congenital heart disease field. The IMPACT Registry is focused on evaluating the use, risks, adverse events (AEs), and outcomes associated with diagnostic and common interventional catheterization procedures in all children and adults with congenital heart disease. Utilizing a modular approach, the common procedures include diagnostic cardiac catheterization, atrial septal defect device closure, patent ductus arteriosus device closure, pulmonary valvuloplasty, aortic valvuloplasty, balloon and stent angioplasty of coarctation of the aorta, pulmonary artery balloon stent angioplasty, transcatheter pulmonary valve replacement, and electrophysiology procedures including radiofrequency ablation. Read More

World J Pediatr Congenit Heart Surg 2019 01;10(1):105-108

2 Department of Heart Valve Disease, National Medical Research Center, Novosibirsk, Russia.

The neonatal management of critical aortic arch obstruction in association with an arterial duct that remains closed or significantly constricted requires urgent surgical repair, with a postoperative focus on resolving the impaired function of compromised organs. Here, we present two neonatal cases illustrating the use of the dual arterial cannulation perfusion method in the complete repair of interrupted aortic arch and critical coarctation of the aorta with nonfunctional ductus arteriosus. We suggest that dual arterial cannulation, which provides total body perfusion (with the exception of cardiac perfusion during cardioplegic arrest of the heart), may be a good alternative to other perfusion strategies in cases of absent ductal blood flow, as this method allowed us to avoid the further development of severe multiple organ failure. Read More

Asian Cardiovasc Thorac Ann 2019 Feb 24:218492319833268. Epub 2019 Feb 24.

3 Department of Pediatric Cardiology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Okinawa Prefecture, Japan.

A neonate was diagnosed with ventricular septal defect and aortic coarctation. Bilateral pulmonary artery banding was performed at 9 days of age (weight 1472 g). Because of ductal shock, emergency extracorporeal membrane oxygenation was initiated after surgery. Read More

Eur J Hum Genet 2019 Feb 22. Epub 2019 Feb 22.

Center of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.

Progressive dilatation of the thoracic aorta leads to thoracic aortic aneurysm (TAA), which is often asymptomatic but predisposes to lethal aortic dissections and ruptures. TAA is a common complication in patients with bicuspid aortic valve (BAV). Recently, rare loss-of-function SMAD6 variants were shown to contribute significantly to the genetic aetiology of BAV/TAA. Read More

Surg Neurol Int 2019 18;10. Epub 2019 Jan 18.

Neurology and Neurosurgery Institute, Zambrano Hellion Hospital, Tecnologico de Monterrey, San Pedro Garza Garcia, Mexico.

Cureus 2018 Dec 5;10(12):e3690. Epub 2018 Dec 5.

Pediatric Cardiology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, USA.

Coarctation of aorta (CoA) is a discrete narrowing in aorta causing obstruction to the flow of blood. It accounts for 6-8% of all congenital heart diseases. With advances in fetal echocardiography rate of prenatal diagnosis of coarctation of aorta has improved but it still remains a challenging diagnosis to make prenatally. Read More

Asian Cardiovasc Thorac Ann 2019 Feb 12:218492318804948. Epub 2019 Feb 12.

1 Department of Pediatric Cardiac Surgery, Vall d'Hebron University Hospital Barcelona, Spain.

The case of a newborn with a post-ductal interrupted aortic arch combined with severe hypoplasia of the thoracic descending aorta and intracardiac defects is described. Extraanatomic bypass surgery was performed in the neonatal period to connect the ascending and descending parts of the aorta. Closure of a ventricular septal defect and excision of hypertrophied bands in the right ventricle with subsequent ventriculotomy were delayed beyond neonatal age. Read More

J Thorac Dis 2018 Dec;10(12):6578-6584

Department of Surgery, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450018, China.

Background: Based on CT image data, a computational fluid dynamics (CFD) model of the aortic arch was established. We aimed to investigate the hemodynamic features associated with end-to-side anastomosis (ESA) surgery for coarctation of the aorta (CoA) by CFD model.

Methods: The data of enhanced CT two-dimensional medical images obtained through clinical practice were processed using medical image post-processing software. Read More

Cardiovasc Diagn Ther 2018 Dec;8(6):780-788

Department of Cardiac and Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.

Prevalence of congenital heart disease (CHD) is constantly increasing during the last decades in line with the treatment options for patients ranging from the surgical as well to the interventional spectrum. This mini-review addresses two of the most common defects with bicuspid aortic valve (BAV) and coarctation of the aorta (CoA). Both diseases are connected to aortic vasculopathy which is one of the most common reasons for morbidity and mortality in young patients with CHD. Read More

Cardiovasc Diagn Ther 2018 Dec;8(6):725-738

Department of Cardiology, Cardiovascular Center, St Luke's International Hospital, Tokyo, Japan.

A bicuspid aortic valve and/or coarctation of the aorta (COA) are often associated with dilatation of the ascending aorta and para-coarctation. Congenital heart diseases (CHD), such as truncus arteriosus, transposition of the great arteries (TGA), tetralogy of Fallot (TOF), hypoplastic left heart syndrome (HLHS), single ventricle with pulmonary stenosis/atresia and the Fontan procedure, are also associated with aortic root dilatation, aneurysm and rarely, dissection, which can be fatal and require aortic valve and root surgery. A significant subset of adults with complex CHD exhibit progressive dilatation of the aortic root even after repair due to aortic medial degeneration. Read More

Eur Heart J Cardiovasc Imaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, No. 37 GuoXue Xiang, Chengdu, Sichuan, People's Republic of China.

J Cardiol 2019 Jan 29. Epub 2019 Jan 29.

Mathematics and Modeling in Medicine Group, Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK; Insigneo Institute for in silico Medicine, Sheffield, UK. Electronic address:

Background: Non-invasive estimation of the pressure gradient in aortic coarctation has much clinical importance in assisting the diagnosis and treatment of the disease. Previous researchers applied computational fluid dynamics for the prediction of the pressure gradient in aortic coarctation. The accuracy of the prediction was satisfactory but the procedure was time-consuming and resource-demanding. Read More

J Biomech 2019 Mar 19;85:108-117. Epub 2019 Jan 19.

Department of Management and Engineering (IEI), Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.

Disturbed, turbulent-like blood flow promotes chaotic wall shear stress (WSS) environments, impairing essential endothelial functions and increasing the susceptibility and progression of vascular diseases. These flow characteristics are today frequently detected at various anatomical, lesion and intervention-related sites, while their role as a pathological determinant is less understood. To present-day, numerous WSS-based descriptors have been proposed to characterize the spatiotemporal nature of the WSS disturbances, however, without differentiation between physiological laminar oscillations and turbulence-related WSS (tWSS) fluctuations. Read More

Artif Organs 2019 Jan 30. Epub 2019 Jan 30.

Pediatric Cardiac Surgery Unit, University of Bologna, Bologna, Italy.

The results of neonatal aortic arch surgery using cerebro-myocardial perfusion were analyzed. Selective cerebral and myocardial perfusion, using two separate pump rotors, was compared with standard perfusion, using a single pump rotor with an arterial line Y-connector. Between May 2008 and May 2016, 69 consecutive neonates underwent arch repair using either selective cerebro-myocardial perfusion (Group A, n = 34) or standard perfusion (Group B, n = 35). Read More

Cardiol Young 2019 Jan 30:1-3. Epub 2019 Jan 30.

Division of Cardiology,Department of Pediatrics,Children's Hospital of Michigan,Detroit,MI,USA.

Congenital complete tracheal rings are usually associated with pulmonary slings. We report a rare association of congenital complete tracheal rings with hypoplastic left heart variant. A term infant with diagnosis of a mildly hypoplastic mitral valve, unicuspid aortic valve, and moderately hypoplastic aortic arch with severe coarctation underwent a hybrid procedure initially. Read More

J Thorac Cardiovasc Surg 2019 Feb 22;157(2):684-695.e8. Epub 2018 Nov 22.

Division of Pediatric Cardiac Surgery, Rady Children's Hospital, San Diego, Calif.

Objective: Arch obstruction after the Norwood procedure is common and contributes to mortality. We determined the prevalence, associated factors, and practice variability of arch reintervention and assessed whether arch reintervention is associated with mortality.

Methods: From 2005 to 2017, 593 neonates in the Congenital Heart Surgeons' Society Critical Left Heart Obstruction cohort underwent a Norwood procedure. Read More

Congenit Heart Dis 2019 Jan 16. Epub 2019 Jan 16.

Division of Cardiology, Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.

Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B-natriuretic peptide are biomarkers that have been associated with pathologic LV change in adult populations but their predictive value following pediatric coarctation repair are not known.

Hypothesis: Biomarker levels at coarctation repair will predict persistent left ventricular remodeling at 1-year follow up. Read More

J Cardiovasc Surg (Torino) 2019 Feb;60(1):152-154

Department of Cardiothoracic Surgery, Academic Medical Center, Amsterdam, The Netherlands -

J Paediatr Child Health 2019 Jan 12. Epub 2019 Jan 12.

Department of Paediatric Cardiology and Adult with Congenital Heart Disease, Onassis Cardiac Surgery Center, Athens, Greece.

Semin Cardiothorac Vasc Anesth 2019 Jan 7:1089253218821953. Epub 2019 Jan 7.

1 Seattle Children's Hospital, Seattle, WA, USA.

Isolated coarctation of the aorta is a relatively common form of congenital heart disease that is characterized by variable degrees of obstruction to aortic outflow. The clinical presentation varies from asymptomatic arterial hypertension to cardiogenic shock. The treatment options include surgical repair or interventional therapy with aortic balloon dilation and stent placement. Read More

Pediatr Cardiol 2019 Feb 2;40(2):276-282. Epub 2019 Jan 2.

Pediatric and Congenital Cardiology, Louis Pradel Hospital, Hospices Civils de Lyon, University Medical Center, 69677, Bron Cedex, France.

To assess the outcomes of neonates prenatally diagnosed with ventricular asymmetry and not operated on within the neonatal period and to determine the risk factors for left heart obstruction occurrence at follow-up. All neonates with prenatal asymmetry of the ventricles, diagnosed from August 1993 to July 2015, not operated on within the neonatal period, were retrospectively included in the study. Left heart echocardiographic measurements at birth and at last follow-up were collected and compared. Read More

Rev Port Cir Cardiotorac Vasc 2018 Jul-Dec;25(3-4):127-129

Cardiothoracic Surgery Department, Centro Hospitalar de Vila Nova de Gaia/Espinho - Vila Nova de Gaia, Portugal.

Aortic coarctation and bicuspid aortic valve frequently coexist. Correction frequently require an aggressive, invasive approach. Here we present a case of a two-stage minimally invasive intervention without sternotomy to correct aortic coarctation and replace the native bicuspid aortic valve. Read More

Egypt Heart J 2018 Dec 30;70(4):255-260. Epub 2018 May 30.

Section of Pediatric Cardiac Intensive Care, King Abdulaziz Medical City, Department of Cardiac Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Objectives: Coarctation of the aorta represents 5-8% of all congenital heart diseases Children with severe coarctation of the aorta may present with significant depression of myocardial function. The aim of this study is to identify short and midterm outcomes of neonates and infants with isolated coarctation of the aorta and depressed left ventricular systolic function with regard to recovery of their cardiac function.

Methods: All patients with isolated coarctation of the aorta who underwent surgical repair between December 2002 and December 2015 were retrospectively reviewed in a cohort study. Read More

J Clin Hypertens (Greenwich) 2019 Feb 25;21(2):291-298. Epub 2018 Dec 25.

Department of Pediatric and Adult Congenital Cardiology, Hôpital Haut-Lévêque, University Hospital, Bordeaux, France.

Native coarctation of the aorta (CoA) and recoarctation (reCoA) after initial surgical repair are frequently associated with hypertension (HT). Most CoA cases are amenable to transcatheter balloon angioplasty with stent implantation; however, the impact of stenting on arterial blood pressure (BP) is variable. We carried out a retrospective study to identify the predictive factors for residual HT despite optimal endovascular treatment. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):885-889

Taiji Clinic, Taipei, Taiwan. Electronic address:

Objective: To present an accurate prenatal diagnosis of coarctation of the aorta with ventricular septal defect and to illustrate how early diagnosis in prenatal period with proper referral and counseling can optimize management.

Case Report: A case with coarctation of the aorta with ventricle septal defect was found to have an abnormal three vessel view at 12 weeks, and with close follow-ups, coarctation of the aorta with ventricle septal defect was diagnosed at 24 weeks. Following the support from a multidisciplinary team that provided counseling, diagnosis, and follow-ups, the pregnant woman decided to continue with the pregnancy and had a vaginal delivery at a medical center. Read More

J Cardiovasc Magn Reson 2018 12 13;20(1):80. Epub 2018 Dec 13.

Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark.

Background: Women with Turner Syndrome have an increased risk for aortic dissection. Arterial stiffening is a risk factor for aortic dilatation and dissection. Here we investigate if arterial stiffening can be observed in Turner Syndrome patients and is an initial step in the development of aortic dilatation and subsequent dissection. Read More

J Anat 2019 Feb 7;234(2):193-200. Epub 2018 Dec 7.

Paediatric Cardiology, Centre de Référence Malformations Cardiaques Congénitales Complexes - M3C, Necker Hospital for Sick Children, Assistance Publique des Hôpitaux de Paris, Paris, France.

The aim of this study was to analyse the anatomy of the ventricular septal defect (VSD) in heart specimens with interruption of the aortic arch (IAA) in order to explore the hypothesis of different embryologic mechanisms for the different anatomic types of IAA. We examined 42 human heart specimens, 25 with IAA as the main disease with concordant atrioventricular and ventriculo-arterial connections and two distinct great arteries, and 17 hearts with IAA associated with other malformations [six common arterial trunk (CAT), five double-outlet right ventricle (DORV), three transposition of the great arteries (TGA), three atrioventricular septal defect (AVSD)]. The interruption was classified according to Celoria and Patton. Read More

J Vasc Surg 2019 Mar 24;69(3):671-679.e1. Epub 2018 Oct 24.

Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minn.

Objective: The objective of this study was to evaluate outcomes of endovascular treatment of aortic coarctation in adults.

Methods: Clinical data and imaging studies of 93 consecutive patients treated at nine institutions from 1999 to 2015 were reviewed. We included newly diagnosed aortic coarctation (NCO), recurrent coarctation, and aneurysmal/pseudoaneurysmal degeneration (ANE) after prior open surgical repair (OSR) of coarctation. Read More

Folia Med Cracov 2018 ;58(3):11-21

Department of Pediatric Cardiac Surgery, University Children's Hospital, Jagiellonian University Medical College, Wielicka 265, Kraków, Poland.

Background: Recoarctation (reCoA) of the aorta is a common complication afer the Norwood procedure. Untreated, it can lead to failure of the systemic ventricle and death. The main goal of the study is to define risk factors of reCoA after the Norwood procedure in hypoplastic left heart syndrome (HLHS). Read More

Acta Cardiol 2018 Dec 3:1-8. Epub 2018 Dec 3.

c Institute of Cardiology , Jagiellonian University Medical College, John Paul II Hospital , Krakow , Poland.

Objectives: The coarctation of aorta is commonly related to bicuspid aortic valve. The aim of the study was to assess arterial stiffness in adults after aortic coarctation repair and to evaluate an impact of bicuspid aortic valve concomitance on arterial stiffness results.

Methods: Fifty-eight patients after coarctation of aorta repair, 36 male, median age of 27. Read More

J Thorac Dis 2018 Oct;10(10):5842-5849

Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: To explore surgical management of complex coarctation of aorta (COA) concomitant with intracardiac abnormality, in order to provide recommendations for safe and reliable treatment.

Methods: Totally, six adult cases demonstrating complex COA concomitant with intracardiac abnormality were reviewed from our department between May 2012 and June 2017. Four patients were male and two patients were female, the age range being 43. Read More

BMC Anesthesiol 2018 Nov 30;18(1):178. Epub 2018 Nov 30.

Department of Anesthesia , Surgical Intensive Care and Pain Management, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Surgery for aortic coarctation requires special care during anesthesia due to severe pain during the lateral thoracotomy incision, intraoperative hemodynamic instability and the need for large doses of intra- and postoperative analgesics and vasodilators. Additionally, the postoperative care of patients is very important.

Aims: We aimed to compare ultrasound-guided paravertebral block performed using bupivacaine alone and bupivacaine with dexamethasone in terms of the intra- and postoperative analgesic requirements and hemodynamics, postoperative complications and ICU stay. Read More

Multimed Man Cardiothorac Surg 2018 11 7;2018. Epub 2018 Nov 7.

Cardiac Surgery Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland.

The goal of surgical treatment of aortic coarctation is to relieve the pressure gradient on the aorta and to allow for subsequent growth of the repaired aorta. In this regard, coarctation resection and extended end-to-end anastomosis has become the surgical gold standard. Early and long-term results have been reported to be excellent. Read More

Multimed Man Cardiothorac Surg 2018 Nov 9;2018. Epub 2018 Nov 9.

Medizinische Universität Innsbruck Anichstrasse 35 6020 Innsbruck Austria.

Open surgery after failed endovascular aortic repair remains an important therapy. The potential modes of stent-graft failure include: type I endoleaks; progression of the aortic disease at the landing zones or proximal/distal to them persistent false lumen perfusion in post-dissection aneurysms; retrograde aortic dissection; stent-graft infection; and stent-graft collapse, fracture, or dislocation. The mortality associated with those procedures can be up to 20% depending on the complexity of the operation and the comorbidities of the patient, especially the presence of graft infection. Read More

Radiol Clin North Am 2019 Jan;57(1):113-125

Department of Radiology, The University of Chicago, 5841 South Maryland Avenue, MC 2026, Chicago, IL 60637, USA.

Congenital abnormalities of the thoracic aorta encompass a variety of disorders with variable clinical manifestations ranging from asymptomatic to life threatening. A variety of imaging modalities are available for the evaluation of these anomalies with computed tomography (CT) commonly preferred due to its excellent spatial resolution and rapid acquisitions, avoiding the need of general anesthesia or even sedation. We review the embryology, imaging findings, and associations of multiple congenital thoracic aorta malformations with emphasis in the role of CT angiography in the evaluation of these pathologies. Read More

Interv Cardiol Clin 2019 Jan 25;8(1):47-58. Epub 2018 Oct 25.

The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

Coarctation of the aorta is a common congenital heart defect and can present at any age. Infants may carry a fetal diagnosis, or are generally diagnosed after auscultation of a murmur, although rarely present in shock. Those that escape early childhood detection typically present in adolescence and adulthood, generally with upper-extremity hypertension. Read More

JACC Cardiovasc Interv 2018 Dec 15;11(23):e191-e194. Epub 2018 Nov 15.

Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran; Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

J Pediatr Endocrinol Metab 2018 Dec;31(12):1355-1361

Pediatrics' Department, Division of Cardiology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background Turner syndrome (TS) patients have increased cardiovascular risk. This cardiovascular risk is famously attributed to structural abnormalities of the left side of the heart such as aortic stenosis and aortic coarctation. However, due to insulin resistance and subsequent pathogenic mechanisms, normotensive TS patients without structural abnormalities may develop varying degrees of myocardial dysfunction. Read More

Tunis Med 2018 Aug - Sep;96(8-09):514-519

Methods: This is a retrospective study including 47 patients with isthmic coarctation (CoA) diagnosed in ante et postnatal périod, hospitalized in pediatric cardiology departement of la Rabta Hospital-Tunisia during the period from 2000 to 2017.

Results: They were 36 girls and 11 boys with an average age of 14 days. The diagnosis of CoA was suspected during the anténatalperiod in eight cases. Read More

Future Cardiol 2018 11 13;14(6):483-489. Epub 2018 Nov 13.

Department of Medicine, University of Arizona, School of Medicine, Tucson, Arizona, USA.

We found a coexistence of Mahaim fibers, coarctation of aorta and bicuspid valve in a young patient presenting with palpitations and subraventricular tachycardia. This rare combination of these three congenital cardiac abnormalities occurring in the same patient has not been reported previously. Detailed cardiac studies unmasked the patient's cardiac abnormalities. Read More

Life Sci 2019 Jan 8;216:22-28. Epub 2018 Nov 8.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del IPN, D.F., México, Plan de San Luis y Díaz Mirón, Casco de Santo Tomás, México 11340 D.F., Mexico. Electronic address:

Aims: Pregnancy is a physiological stage with profound cardiovascular changes leading to hypotension. Preeclampsia (PE) reverts these normal changes inducing hypertension. Renin-angiotensin system (RAS) has been related in PE genesis. Read More