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Congenit Heart Dis 2019 Jan 16. Epub 2019 Jan 16.

Division of Cardiology, Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.

Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B-natriuretic peptide are biomarkers that have been associated with pathologic LV change in adult populations but their predictive value following pediatric coarctation repair are not known.

Hypothesis: Biomarker levels at coarctation repair will predict persistent left ventricular remodeling at 1-year follow up. Read More

J Cardiovasc Surg (Torino) 2019 Feb;60(1):152-154

Department of Cardiothoracic Surgery, Academic Medical Center, Amsterdam, The Netherlands -

J Paediatr Child Health 2019 Jan 12. Epub 2019 Jan 12.

Department of Paediatric Cardiology and Adult with Congenital Heart Disease, Onassis Cardiac Surgery Center, Athens, Greece.

Semin Cardiothorac Vasc Anesth 2019 Jan 7:1089253218821953. Epub 2019 Jan 7.

1 Seattle Children's Hospital, Seattle, WA, USA.

Isolated coarctation of the aorta is a relatively common form of congenital heart disease that is characterized by variable degrees of obstruction to aortic outflow. The clinical presentation varies from asymptomatic arterial hypertension to cardiogenic shock. The treatment options include surgical repair or interventional therapy with aortic balloon dilation and stent placement. Read More

Pediatr Cardiol 2019 Jan 2. Epub 2019 Jan 2.

Pediatric and Congenital Cardiology, Louis Pradel Hospital, Hospices Civils de Lyon, University Medical Center, 69677, Bron Cedex, France.

To assess the outcomes of neonates prenatally diagnosed with ventricular asymmetry and not operated on within the neonatal period and to determine the risk factors for left heart obstruction occurrence at follow-up. All neonates with prenatal asymmetry of the ventricles, diagnosed from August 1993 to July 2015, not operated on within the neonatal period, were retrospectively included in the study. Left heart echocardiographic measurements at birth and at last follow-up were collected and compared. Read More

Rev Port Cir Cardiotorac Vasc 2018 Jul-Dec;25(3-4):127-129

Cardiothoracic Surgery Department, Centro Hospitalar de Vila Nova de Gaia/Espinho - Vila Nova de Gaia, Portugal.

Aortic coarctation and bicuspid aortic valve frequently coexist. Correction frequently require an aggressive, invasive approach. Here we present a case of a two-stage minimally invasive intervention without sternotomy to correct aortic coarctation and replace the native bicuspid aortic valve. Read More

Egypt Heart J 2018 Dec 30;70(4):255-260. Epub 2018 May 30.

Section of Pediatric Cardiac Intensive Care, King Abdulaziz Medical City, Department of Cardiac Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Objectives: Coarctation of the aorta represents 5-8% of all congenital heart diseases Children with severe coarctation of the aorta may present with significant depression of myocardial function. The aim of this study is to identify short and midterm outcomes of neonates and infants with isolated coarctation of the aorta and depressed left ventricular systolic function with regard to recovery of their cardiac function.

Methods: All patients with isolated coarctation of the aorta who underwent surgical repair between December 2002 and December 2015 were retrospectively reviewed in a cohort study. Read More

J Clin Hypertens (Greenwich) 2018 Dec 25. Epub 2018 Dec 25.

Department of Pediatric and Adult Congenital Cardiology, Hôpital Haut-Lévêque, University Hospital, Bordeaux, France.

Native coarctation of the aorta (CoA) and recoarctation (reCoA) after initial surgical repair are frequently associated with hypertension (HT). Most CoA cases are amenable to transcatheter balloon angioplasty with stent implantation; however, the impact of stenting on arterial blood pressure (BP) is variable. We carried out a retrospective study to identify the predictive factors for residual HT despite optimal endovascular treatment. Read More

J Cardiovasc Magn Reson 2018 Dec 13;20(1):80. Epub 2018 Dec 13.

Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark.

Background: Women with Turner Syndrome have an increased risk for aortic dissection. Arterial stiffening is a risk factor for aortic dilatation and dissection. Here we investigate if arterial stiffening can be observed in Turner Syndrome patients and is an initial step in the development of aortic dilatation and subsequent dissection. Read More

J Anat 2019 Feb 7;234(2):193-200. Epub 2018 Dec 7.

Paediatric Cardiology, Centre de Référence Malformations Cardiaques Congénitales Complexes - M3C, Necker Hospital for Sick Children, Assistance Publique des Hôpitaux de Paris, Paris, France.

The aim of this study was to analyse the anatomy of the ventricular septal defect (VSD) in heart specimens with interruption of the aortic arch (IAA) in order to explore the hypothesis of different embryologic mechanisms for the different anatomic types of IAA. We examined 42 human heart specimens, 25 with IAA as the main disease with concordant atrioventricular and ventriculo-arterial connections and two distinct great arteries, and 17 hearts with IAA associated with other malformations [six common arterial trunk (CAT), five double-outlet right ventricle (DORV), three transposition of the great arteries (TGA), three atrioventricular septal defect (AVSD)]. The interruption was classified according to Celoria and Patton. Read More

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minn.

Objective: The objective of this study was to evaluate outcomes of endovascular treatment of aortic coarctation in adults.

Methods: Clinical data and imaging studies of 93 consecutive patients treated at nine institutions from 1999 to 2015 were reviewed. We included newly diagnosed aortic coarctation (NCO), recurrent coarctation, and aneurysmal/pseudoaneurysmal degeneration (ANE) after prior open surgical repair (OSR) of coarctation. Read More

Folia Med Cracov 2018 ;58(3):11-21

Department of Pediatric Cardiac Surgery, University Children's Hospital, Jagiellonian University Medical College, Wielicka 265, Kraków, Poland.

Background: Recoarctation (reCoA) of the aorta is a common complication afer the Norwood procedure. Untreated, it can lead to failure of the systemic ventricle and death. The main goal of the study is to define risk factors of reCoA after the Norwood procedure in hypoplastic left heart syndrome (HLHS). Read More

Acta Cardiol 2018 Dec 3:1-8. Epub 2018 Dec 3.

c Institute of Cardiology , Jagiellonian University Medical College, John Paul II Hospital , Krakow , Poland.

Objectives: The coarctation of aorta is commonly related to bicuspid aortic valve. The aim of the study was to assess arterial stiffness in adults after aortic coarctation repair and to evaluate an impact of bicuspid aortic valve concomitance on arterial stiffness results.

Methods: Fifty-eight patients after coarctation of aorta repair, 36 male, median age of 27. Read More

J Thorac Dis 2018 Oct;10(10):5842-5849

Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: To explore surgical management of complex coarctation of aorta (COA) concomitant with intracardiac abnormality, in order to provide recommendations for safe and reliable treatment.

Methods: Totally, six adult cases demonstrating complex COA concomitant with intracardiac abnormality were reviewed from our department between May 2012 and June 2017. Four patients were male and two patients were female, the age range being 43. Read More

BMC Anesthesiol 2018 Nov 30;18(1):178. Epub 2018 Nov 30.

Department of Anesthesia , Surgical Intensive Care and Pain Management, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Surgery for aortic coarctation requires special care during anesthesia due to severe pain during the lateral thoracotomy incision, intraoperative hemodynamic instability and the need for large doses of intra- and postoperative analgesics and vasodilators. Additionally, the postoperative care of patients is very important.

Aims: We aimed to compare ultrasound-guided paravertebral block performed using bupivacaine alone and bupivacaine with dexamethasone in terms of the intra- and postoperative analgesic requirements and hemodynamics, postoperative complications and ICU stay. Read More

Multimed Man Cardiothorac Surg 2018 11 7;2018. Epub 2018 Nov 7.

Cardiac Surgery Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland.

The goal of surgical treatment of aortic coarctation is to relieve the pressure gradient on the aorta and to allow for subsequent growth of the repaired aorta. In this regard, coarctation resection and extended end-to-end anastomosis has become the surgical gold standard. Early and long-term results have been reported to be excellent. Read More

Multimed Man Cardiothorac Surg 2018 Nov 9;2018. Epub 2018 Nov 9.

Medizinische Universität Innsbruck Anichstrasse 35 6020 Innsbruck Austria.

Open surgery after failed endovascular aortic repair remains an important therapy. The potential modes of stent-graft failure include: type I endoleaks; progression of the aortic disease at the landing zones or proximal/distal to them persistent false lumen perfusion in post-dissection aneurysms; retrograde aortic dissection; stent-graft infection; and stent-graft collapse, fracture, or dislocation. The mortality associated with those procedures can be up to 20% depending on the complexity of the operation and the comorbidities of the patient, especially the presence of graft infection. Read More

Radiol Clin North Am 2019 Jan;57(1):113-125

Department of Radiology, The University of Chicago, 5841 South Maryland Avenue, MC 2026, Chicago, IL 60637, USA.

Congenital abnormalities of the thoracic aorta encompass a variety of disorders with variable clinical manifestations ranging from asymptomatic to life threatening. A variety of imaging modalities are available for the evaluation of these anomalies with computed tomography (CT) commonly preferred due to its excellent spatial resolution and rapid acquisitions, avoiding the need of general anesthesia or even sedation. We review the embryology, imaging findings, and associations of multiple congenital thoracic aorta malformations with emphasis in the role of CT angiography in the evaluation of these pathologies. Read More

Interv Cardiol Clin 2019 Jan 25;8(1):47-58. Epub 2018 Oct 25.

The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

Coarctation of the aorta is a common congenital heart defect and can present at any age. Infants may carry a fetal diagnosis, or are generally diagnosed after auscultation of a murmur, although rarely present in shock. Those that escape early childhood detection typically present in adolescence and adulthood, generally with upper-extremity hypertension. Read More

JACC Cardiovasc Interv 2018 Dec 15;11(23):e191-e194. Epub 2018 Nov 15.

Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran; Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

J Pediatr Endocrinol Metab 2018 Dec;31(12):1355-1361

Pediatrics' Department, Division of Cardiology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background Turner syndrome (TS) patients have increased cardiovascular risk. This cardiovascular risk is famously attributed to structural abnormalities of the left side of the heart such as aortic stenosis and aortic coarctation. However, due to insulin resistance and subsequent pathogenic mechanisms, normotensive TS patients without structural abnormalities may develop varying degrees of myocardial dysfunction. Read More

Tunis Med 2018 Aug - Sep;96(8-09):514-519

Methods: This is a retrospective study including 47 patients with isthmic coarctation (CoA) diagnosed in ante et postnatal périod, hospitalized in pediatric cardiology departement of la Rabta Hospital-Tunisia during the period from 2000 to 2017.

Results: They were 36 girls and 11 boys with an average age of 14 days. The diagnosis of CoA was suspected during the anténatalperiod in eight cases. Read More

Future Cardiol 2018 Nov 13. Epub 2018 Nov 13.

Department of Medicine, University of Arizona, School of Medicine, Tucson, Arizona, USA.

We found a coexistence of Mahaim fibers, coarctation of aorta and bicuspid valve in a young patient presenting with palpitations and subraventricular tachycardia. This rare combination of these three congenital cardiac abnormalities occurring in the same patient has not been reported previously. Detailed cardiac studies unmasked the patient's cardiac abnormalities. Read More

Life Sci 2019 Jan 8;216:22-28. Epub 2018 Nov 8.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del IPN, D.F., México, Plan de San Luis y Díaz Mirón, Casco de Santo Tomás, México 11340 D.F., Mexico. Electronic address:

Aims: Pregnancy is a physiological stage with profound cardiovascular changes leading to hypotension. Preeclampsia (PE) reverts these normal changes inducing hypertension. Renin-angiotensin system (RAS) has been related in PE genesis. Read More

Ann Thorac Surg 2018 Nov 8. Epub 2018 Nov 8.

Division of Congenital Heart Surgery, Department of Surgery, Medical College of Wisconsin; Herma Heart Institute, Children's Hospital of Wisconsin.

Optimal management- balloon dilation versus surgical valvotomy- of neonatal critical aortic stenosis (AS) remains controversial. We describe a term neonate with critical AS and coarctation, severe left ventricular (LV) dysfunction with endocardial fibro-elastosis palliated with surgical valvotomy and hybrid as a bridge to early biventricular repair. Initial repair consisted of commissurotomy to create bicuspid morphology with placement of bilateral pulmonary artery bands and maintenance of ductal patency with prostaglandin. Read More

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):404-415. Epub 2018 Nov 6.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

The bicuspid aortic valve (BAV) condition is characterized by prominent heterogeneity of its valvular phenotypic expression, of its associated disorders, its complications and its prognosis. Echocardiography serves as the first-line imaging modality in 5 major capacities: (1) BAV diagnosis, (2) valvular phenotyping, (3) assessment of valvular function, (4) measurement of the thoracic aorta and exclusion of aortic coarctation, and (5) assessment of uncommon but serious complications such as infective endocarditis and aortic dissection. This article presents a nosological perspective on the BAV condition, discusses the critical role of echocardiography as it relates to these 5 aforementioned capacities; and makes the case for a unified standard nomenclature for the BAV condition. Read More

Congenit Heart Dis 2018 Sep 5;13(5):713-720. Epub 2018 Nov 5.

Department of Pediatric Cardiology, Mount Sinai Hospital, New York, New York.

Objective: The most accurate noninvasive parameter to predict whether a patient with aortic coarctation will meet interventional criteria at catheterization remains elusive. We aim to determine the best independent echocardiographic predictors of a coarctation peak-to-peak pressure gradient ≥20 mm Hg at catheterization, the accepted threshold for intervention.

Design: Retrospective query of our catheterization database from 1/2007 to 7/2016 for the diagnostic code of aortic coarctation was performed. Read More

Cardiol Young 2018 Nov 5. Epub 2018 Nov 5.

Ann Thorac Surg 2018 Oct 31. Epub 2018 Oct 31.

Emory University, Atlanta, GA, Department of Pediatrics and Sibley Heart Center.

Background: The Pediatric Heart Network Collaborative Learning Study (PHN CLS) successfully changed practice at 4 hospitals to increase the rate of early extubation within 6 hours after infant heart surgery. It is unknown whether this practice continued after study completion.

Methods: We linked the PHN CLS dataset to the Pediatric Cardiac Critical Care Consortium registry to compare outcomes at 4 active hospitals between the study period (post-CPG) and the first year after study completion (follow-up) after a 3-month washout. Read More

J Magn Reson Imaging 2019 Jan 3;49(1):81-89. Epub 2018 Nov 3.

Institute for Computational and Imaging Science in Cardiovascular Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.

Background: Invasive peak-to-peak pressure gradients are the current clinical reference standard for assessing aortic coarctation. To obtain them, patients need to undergo arterial heart catheterization. Unless an intervention is performed, the procedure remains purely diagnostic, while the concomitant risks remain. Read More

Climacteric 2018 Dec 1;21(6):536-541. Epub 2018 Nov 1.

a Center of Genetic and Prenatal Diagnosis, Department of Gynecology , The First Affiliated Hospital of Zhengzhou University , Henan Province , China.

Ovarian dysgenesis, short stature, and infertility are common features of Turner syndrome (TS). Endocrinopathies and cardiopathies are less common, but may induce significant complications, and are the leading cause of mortality in TS patients. Endocrine abnormality including osteoporosis occurs in up to 60% of patients, hypothyroidism at an incidence of 3. Read More

Eur J Cardiothorac Surg 2018 Oct 30. Epub 2018 Oct 30.

Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: This study aimed to explore aortic morphology and the associations between morphological features and cardiovascular function in a population of patients with bicuspid aortic valve, while further assessing differences between patients with repaired coarctation, patients with unrepaired coarctation and patients without coarctation.

Methods: This is a single-centre retrospective study that included patients with available cardiovascular magnetic resonance imaging data and native bicuspid aortic valve diagnosis (n = 525). A statistical shape analysis was performed on patients with a 3-dimensional magnetic imaging resonance (MRI) dataset (n = 108), deriving 3-dimensional aortic reconstructions and computing a mean aortic shape (template) for the whole population as well as for the 3 subgroups of interest (no coarctation, repaired coarctation and unrepaired coarctation). Read More

Circ Cardiovasc Imaging 2018 Aug;11(8):e007918

Adult Congenital Heart Disease Unit, Cardiology Department, Royal Brompton Hospital, London, United Kingdom (R.A.-G.).

Circ Genom Precis Med 2018 Oct;11(10):e000048

Girls and women with Turner syndrome face a lifelong struggle with both congenital heart disease and acquired cardiovascular conditions. Bicuspid aortic valve is common, and many have left-sided heart obstructive disease of varying severity, from hypoplastic left-sided heart syndrome to minimal aortic stenosis or coarctation of the aorta. Significant enlargement of the thoracic aorta may progress to catastrophic aortic dissection and rupture. Read More

Med J Malaysia 2018 Oct;73(5):330-331

Hospital Sungai Buloh, Department of Radiology, Sungai Buloh, Selangor, Malaysia.

Coarctation of the aorta (CoA) is present in 0.4% of live births and in 7% of patients with congenital heart disease. While there may be florid presentations of congestive heart failure in the neonatal period, the diagnosis during adulthood is often delayed. Read More

Ann Vasc Surg 2018 Oct 18. Epub 2018 Oct 18.

Department of Vascular Medicine, German Aortic Center Hamburg, University Heart Center of Hamburg, Hamburg, Germany.

Background: Thoracic endovascular aortic repair (TEVAR) with self-expanding endograft is increasingly used as a viable treatment option for adult aortic coarctation (AC).

Methods: We hereby reported a 55-year-old gentleman with late presentation of AC, treated by a novel strategy with thoracic endograft and in situ laser fenestration for left subclavian artery (LSA) revascularization.

Results: AC was incidentally discovered during coronary angiogram as an investigation for his angina pectoris. Read More

Eur Heart J Cardiovasc Imaging 2018 Oct 17. Epub 2018 Oct 17.

Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada.

Aims: The aims of this study were to provide a detailed descriptive analysis of pre-intervention morphologic and functional echocardiographic parameters in a large, unselected, multicentre cohort of neonates diagnosed with critical left heart obstruction and to compare echocardiographic features between the different subtypes of left-sided lesions.

Methods And Results: Pre-intervention echocardiograms for 651 patients from 19 Congenital Heart Surgeons' Society (CHSS) institutions were reviewed in a core lab according to a standardized protocol including >150 morphologic and functional variables. The four most common subtypes of lesions were: aortic atresia (AA)/mitral atresia (MA) (29% of patients), AA/mitral stenosis (MS) (20%), aortic stenosis (AS)/MS (26%), and isolated AS (iAS) (18%). Read More

Pediatr Neurosurg 2018 18;53(6):421-426. Epub 2018 Oct 18.

Interventional Neuroradiology, Hospital Pequeno Principe, Curitiba, Brazil.

PHACE(S) syndrome is a neurocutaneous syndrome with a wide array of presentations. The most known and present trait is facial hemangioma > 5 cm. The name is an acronym for Posterior fossa malformations, infantile Hemangiomas, Arterial anomalies, aortic Coarctation, Eye abnormalities, and middle-line malformations of the Sternum. Read More

BMJ Case Rep 2018 Oct 16;2018. Epub 2018 Oct 16.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.

Anomalous origin of left main coronary artery from non-coronary sinus (LCANCS) is an extremely rare anomaly. Aortic coarctation in association with LCANCS has not been previously described in literature. Read More

World J Pediatr Congenit Heart Surg 2018 11;9(6):659-664

3 Department of Cardiovascular Surgery, Fundación Cardioinfantil, Instituto de Cardiología, Bogotá, Colombia.

Background: The approach to coarctation of the aorta with hypoplastic aortic arch is controversial. We evaluated the outcomes in patients with coarctation of the aorta with or without hypoplastic aortic arch operated through a posterior left lateral thoracotomy.

Methods: A retrospective cohort of patients with aortic coarctation, who underwent repair between January 2009 and October 2017, was analyzed. Read More

World J Pediatr Congenit Heart Surg 2018 11;9(6):665-667

1 Cardiothoracic Surgery Department, Hospital de Santa Marta-Centro Hospitalar Lisboa Central, Lisbon, Portugal.

Angiol Sosud Khir 2018;24(3):169-175

Department of Vascular Surgery, Municipal Multimodality Hospital No2, Saint Petersburg, Russia.

Described herein is a clinical case report concerning treatment of a 32-year-old female patient with rupture of an aneurysm of the arch and descending portion of the thoracic aorta, with the bleeding having penetrated the upper lobe of the left lung. The woman was admitted to the Department of Vascular Surgery of Municipal Multimodality Hospital No 2 of Saint Petersburg, presenting with a clinical pattern of aneurysmal rupture previously diagnosed by computed tomography performed at one of the local hospitals. Studying her case history revealed that, when a child, she had endured an operation for a defect of the interventricular septum and aortic coarctation with aortoplasty using a Dacron synthetic patch. Read More

J Clin Ultrasound 2019 Jan 14;47(1):22-26. Epub 2018 Oct 14.

Department of Ultrasound, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objectives: To discuss Doppler ultrasonographic and clinical features of middle aortic syndrome (MAS).

Materials And Methods: Doppler ultrasonographic images and clinical dates of 11 patients with MAS confirmed by angiography were retrospectively analyzed from January 2004 to September 2016.

Results: The median age of 11 patients was 10 years (1-39 years). Read More

PLoS One 2018 12;13(10):e0205366. Epub 2018 Oct 12.

Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Hemodynamics may play an essential role in the initiation and progression of abdominal aortic aneurysm (AAA). We aimed to study the mechanism of self-healing process by the changes of hemodynamics and pathology in an enlarging AAA in rabbits. Seventy-two rabbits were randomly divided into three groups. Read More

Int Heart J 2018 Nov 10;59(6):1340-1345. Epub 2018 Oct 10.

Department of Child Health, Faculty of Medicine, University of Tsukuba.

Adult patients with repaired coarctation of the aorta (r-CoA) show high prevalence of late hypertension, but the exact mechanisms of this phenomenon are unknown. Endothelial dysfunction has been implicated in this paradoxical hypertension. We evaluated the endothelial function of both conduit and resistance arteries by using flow-mediated dilation (FMD) and digital peripheral artery tonometry (PAT). Read More

Korean J Pediatr 2018 Dec 19;61(12):397-402. Epub 2018 Sep 19.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Transcatheter device closure of patent ductus arteriosus (PDA) is challenging in early infancy. We evaluated PDA closure in infants less than 6 months old.

Methods: We performed a retrospective review of infants less than 6 months of age who underwent attempted transcatheter device closure in our institution since 2004. Read More

Cardiovasc Eng Technol 2018 Dec 3;9(4):582-596. Epub 2018 Oct 3.

Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Forum 4 - 0.0561, 13353, Berlin, Germany.

Purpose: Numerical assessment of the pressure drop across an aortic coarctation using CFD is a promising approach to replace invasive catheter-based measurements. The aim of this study was to investigate and quantify the uncertainty of numerical calculation of the pressure drop introduced during two essential steps of medical image processing: segmentation of the patient-specific geometry and measurement of patient-specific flow rates from 4D-flow-MRI.

Methods: Based on the baseline segmentation, geometries with different stenosis diameters were generated for a sample of ten patients. Read More

J Cardiol Cases 2018 Oct 11;18(4):138-140. Epub 2018 Jul 11.

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

A 38-year-old man underwent surgical repair of a type A aortic dissection. After aortic surgery, his left ventricular ejection fraction was progressively reduced from 65% to 15%, causing a refractory low cardiac output depending on the intravenous inotropes. There was a luminal stenosis of the descending aorta due to enlarged pseudolumen. Read More

J Cardiol Cases 2018 Sep 1;18(3):85-87. Epub 2018 Jun 1.

Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Adult aortic coarctation is often asymptomatic and this condition can be detected because of a murmur or unexplained hypertension. Here, we report an adult case of aortic coarctaion with heart failure and a characteristic finding of pulsation below the bilateral clavicle.　 A 58-year-old man with refractory heart failure due to unknown reasons was referred to our hospital. Read More