160,139 results match your criteria Aorta Stamford Conn.[Journal]


Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta.

Physiol Genomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin.

Coarctation of the aorta (CoA) is a common congenital cardiovascular (CV) defect characterized by a stenosis of the descending thoracic aorta. Treatment exists, but many patients develop hypertension (HTN). Identifying the cause of HTN is challenging because of patient variability (e. Read More

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http://dx.doi.org/10.1152/physiolgenomics.00049.2018DOI Listing

Lysyl oxidase-like 2 (LOXL2) depletion is protective in age-associated vascular stiffening.

Am J Physiol Heart Circ Physiol 2019 Apr 19. Epub 2019 Apr 19.

ACCM, Johns Hopkins University, United States.

Vascular stiffening and its sequelae are major causes of morbidity and mortality in the elderly. The increasingly accepted concept of "smooth muscle cell (SMC) stiffness syndrome" along with matrix deposition has emerged in vascular biology to account for the mechanical phenotype of arterial aging, but the molecular targets remain elusive. In this study, using an unbiased proteomic analysis, we identified lysyl oxidase-like 2 (LOXL2) as a critical SMC mediator for age-associated vascular stiffening. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00670.2018
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http://dx.doi.org/10.1152/ajpheart.00670.2018DOI Listing
April 2019
1 Read

Feasibility of pulmonary valve imaging using transesophageal echocardiography upper esophageal view.

Echocardiography 2019 Apr 19. Epub 2019 Apr 19.

Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado.

Background: The present study designed to evaluate feasibility of transesophageal echocardiographic (TEE) imaging of the pulmonary valve (PV) at the transaortic upper esophageal (TAUE) window. We hypothesized that patients with larger aorta would be more likely to have visualization of the PV from this TAUE window.

Methods: 2D TEE images of the PV were prospectively acquired by one operator at the TAUE window looking through the aortic arch. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/echo.14332
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http://dx.doi.org/10.1111/echo.14332DOI Listing
April 2019
1 Read

MiR-181b regulates atherosclerotic inflammation and vascular endothelial function through Notch1 signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3051-3057

Department of Cadre Health Protection, Liaocheng People's Hospital, Liaocheng, China.

Objective: To explore the influences of micro ribonucleic acid (miR)-181b on the inflammation and vascular endothelial function in atherosclerosis (AS), and its specific molecular regulatory mechanism.

Materials And Methods: 44 apolipoprotein E (ApoE)-/- 7 weeks old male rats were randomly divided into normal diet group (NC group) and AS model group (high-fat diet feeding). Rat aorta was dissected and the serum sample was collected in both groups. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17587DOI Listing

Relationship between systolic hypertension assessed by 24-h ambulatory blood pressure monitoring and aortic diameters in young women with Turner syndrome.

Clin Endocrinol (Oxf) 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Objective: Patients with Turner syndrome (TS) are at high risk for cardiovascular morbidity and mortality due to aortic dilation. We evaluated the prevalence of hypertension and its risk factors, and investigated the relationship between systolic hypertension and aortic diameter in young TS patients.

Design: Observational, cross-sectional study. Read More

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http://dx.doi.org/10.1111/cen.13995DOI Listing

Simplified Methods for Quantification of F-DCFPyL Uptake in Patients with Prostate Cancer.

J Nucl Med 2019 Apr 18. Epub 2019 Apr 18.

Amsterdam University Medical Centers, Netherlands.

Radiolabeled Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) has demonstrated promising results for prostate cancer (PCa) imaging. Quantification of PSMA radiotracer uptake is desired as it enables reliable interpretation of PET-images, the use of PSMA uptake as an imaging biomarker for tumor characterization, and evaluation of treatment effects. The aim of this study was to perform a full pharmacokinetic analysis of F-DCFPyL, a second generation F-labeled PSMA ligand. Read More

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http://dx.doi.org/10.2967/jnumed.119.227520DOI Listing

Comparison of resting and adenosine-free pressure indices with adenosine-induced hyperemic fractional flow reserve in intermediate coronary lesions.

Indian Heart J 2019 Jan - Feb;71(1):74-79. Epub 2018 Dec 10.

Department of Cardiology, Institute of Cardio-Vascular Diseases, Madras Medical Mission, Chennai, Tamilnadu, India. Electronic address:

Objective: Fractional flow reserve (FFR) using adenosine has been the gold standard in the functional assessment of intermediate coronary stenoses in the catheterization laboratory. We aim to study the correlation of adenosine-free indices such as whole cycle Pd/Pa [the ratio of mean distal coronary pressure (Pd) to the mean pressure observed in the aorta (Pa)], instantaneous wave-free ratio (iFR), and contrast-induced submaximal hyperemia (cFFR) with FFR.

Methods: This multicenter, prospective, observational study included patients with stable angina or acute coronary syndrome (>48 h since onset) with discrete intermediate coronary lesions (40-70% diameter stenosis). Read More

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http://dx.doi.org/10.1016/j.ihj.2018.11.016DOI Listing
December 2018

Prognostic impact of the ratio of the main pulmonary artery to that of the aorta on chest computed tomography in patients with idiopathic pulmonary fibrosis.

BMC Pulm Med 2019 Apr 18;19(1):81. Epub 2019 Apr 18.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: In many clinical disorders, there is a relationship between the ratio of the diameter of the main pulmonary artery (mPA) to that of the aorta (Ao) on chest computed tomography (CT). The aim of this study was to determine if the mPA/Ao ratio at diagnosis is associated with the clinical characteristics and outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods: We retrospectively reviewed the diameters of the pulmonary artery and aorta on chest CT, clinical characteristics, and results of other examinations in 303 patients at the time of initial diagnosis of IPF at our tertiary care center between 2011 and 2015. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-019-0843-5DOI Listing
April 2019
1 Read

Identification of circumferential regional heterogeneity of ascending thoracic aneurysmal aorta by biaxial mechanical testing.

J Mol Cell Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT, Via Tricomi n.5, 90127 Palermo, Italy.

Ascending thoracic aortic aneurysm (ATAA) in patients with bicuspid aortic valve (BAV) can present an asymmetrical aortic dilatation compared with patients with tricuspid aortic valve (TAV). This pattern of aneurysm dilatation led us to hypothesize that biomechanical differences likely induced by regional heterogeneity of material properties can underlie the observed asymmetric enlargement discrepancies between BAV ATAA and TAV ATAA. This study aimed to characterize the mechanical properties and associated aortic tissue stiffness changes along the circumferential direction of aortic rings collected from surgically-repaired patients with ATAA. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.010DOI Listing
April 2019
1 Read

Spatial Patterning of Molecular Cues and Vascular Cells in Fully Integrated Hydrogel Channels via Interfacial Bioorthogonal Crosslinking.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

Fully integrated hydrogel channels were fabricated via interfacial bioorthogonal crosslinking - a diffusion-controlled method for the creation and patterning of synthetic matrices based on the rapid bioorthogonal reaction between s-tetrazines (Tz) and trans-cyclooctene (TCO) dienophiles. Injecting an aqueous solution of a bisTCO crosslinker into a reservoir of tetrazine-modified hyaluronic acid (HA-Tz), while simultaneously drawing the syringe needle through the reservoir, yielded a crosslinked hydrogel channel that was mechanically robust. Fluorescent tags and biochemical signals were spatially patterned in the channel wall through time-dependent perfusion of TCO-conjugated molecules into the lumen of the channel. Read More

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http://dx.doi.org/10.1021/acsami.9b04383DOI Listing

Acute exposure to glycated proteins reduces cardiomyocyte contractile capacity.

Exp Physiol 2019 Apr 17. Epub 2019 Apr 17.

Biomedical Research Institute (BIOMED), Hasselt University, Martelarenlaan 42, 3500, Hasselt, Belgium.

New Findings: What is the central question of this research? Does acute exposure to HMW-AGEs alter cardiomyocyte contractile function? What is the main finding and its importance? Ventricular cardiomyocytes display reduced Ca influx, resulting in reduced contractile capacity after acute exposure to HMW-AGEs, independent of RAGE activation. Since HMW-AGEs are abundantly present in our Western diet, a better understanding of underlying mechanisms, in particular in patients displaying already altered cardiac function, should be given to such compounds.

Abstract: Background : Sustained elevated levels of high molecular weight advanced glycation end products (HMW-AGEs) are known to promote cardiac dysfunction. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1113/EP087127
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http://dx.doi.org/10.1113/EP087127DOI Listing
April 2019
1 Read

Left Main Stenting Induced Flow Disturbances on Ascending Aorta and Aortic Arch.

J Transl Int Med 2019 Mar 29;7(1):22-28. Epub 2019 Mar 29.

Director of Cardiovascular Research, Methodist Hospital, Merrillville, IN 46410, USA; Tan Tao University School of Medicine, Long An, Vietnam.

Background And Objective: Ostial LM stenting potentially induces turbulence in the aortic wall near the LM ostium, which might be correlated with aorta dilation and dissection. We investigated through a computational fluid dynamic analysis (CFD), the presence and potential consequences of flow turbulences both in the ascending aorta and arch after a stenting left main (LM) mid shaft or distal disease.

Methods: The model of the ascending aorta and left coronary artery was reconstructed reviewing both angiographic and echocardiographic measurements of 80 consecutive patients (43 males, mean age 75. Read More

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http://dx.doi.org/10.2478/jtim-2019-0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463829PMC
March 2019
1 Read

Are optical trocars free of complications?

Clin Case Rep 2019 Apr 9;7(4):851. Epub 2019 Mar 9.

Division of General, Minimally Invasive and Robotic Surgery, Department of Surgery University of Illinois at Chicago Chicago Illinois.

Optical view trocars provide an acceptable level of safety for port entry during minimally invasive surgery. Nevertheless, this technique is not exempt from potential complications. These can range from a minor subcutaneous insufflation that will not require any further treatment to abdominal aorta injuries. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2091
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http://dx.doi.org/10.1002/ccr3.2091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452478PMC
April 2019
1 Read

Five-Year Patency and its Predictors after Endovascular Therapy for Aortoiliac Occlusive Disease.

J Atheroscler Thromb 2019 Apr 16. Epub 2019 Apr 16.

Cardiovascular Center, Kansai Rosai Hospital.

Aim: Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of the abdominal aorta (Leriche syndrome), endovascular therapy (EVT) has been increasingly utilized because of the development of new technologies and techniques. EVT has demonstrated durable midterm outcomes for aortoiliac occlusive disease (AIOD). Nonetheless, little is known regarding their long-term outcomes and predictors of restenosis. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_456
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http://dx.doi.org/10.5551/jat.45617DOI Listing
April 2019
2 Reads

A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan.

The number of Takayasu arteritis (TAK) cases being diagnosed at an advanced age has increased, including some who develop ischemic lesions without inflammation of the involved arteries long after the onset of TAK. However, few histopathological analyses of such patients without immunosuppressive therapy have been reported. We herein report a 92-year-old woman with atypical aortic coarctation complicating TAK who underwent bypass graft surgery and survived for 23 years without immunosuppressive therapy. Read More

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http://dx.doi.org/10.2169/internalmedicine.2483-18DOI Listing
April 2019
1 Read

Diffusion Weighted Whole Body Imaging with Background Body Signal Suppression (DWIBS) Was Useful for the Diagnosis and Follow-Up of Giant Cell Arteritis.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Research, National Hospital Organization Osaka Minami Medical Center, Japan.

A 66-year-old woman with symptoms of fatigue and headache was diagnosed with giant cell arteritis (GCA). Fluorodeoxyglucose (FDG)-PET/computed tomography (CT) revealed the strong accumulation of FDG in the descending aorta, abdominal aorta, bilateral subclavian artery, and total iliac artery. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) showed signal enhancement at the descending aorta and abdominal aorta. Read More

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http://dx.doi.org/10.2169/internalmedicine.2479-18DOI Listing

Possibility of Cardio-renal Protection by Long-term Cardiac Rehabilitation in Elderly Patients with Cardiovascular Diseases.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, Fukuoka University School of Medicine, Japan.

Objective Cardiac rehabilitation (CR) improves the mortality in patients with cardiovascular disease (CVD). Even in elderly patients with CVD, CR may improve the activities of daily living (ADL). Methods Eighty-eight outpatients over 65 years of age at the beginning of a CR program (baseline) at Fukuoka University Hospital who had CVD and could be followed-up for up to 5 years were enrolled. Read More

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http://dx.doi.org/10.2169/internalmedicine.2281-18DOI Listing
April 2019
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Bicuspid Aortic Valve Alters Aortic Protein Expression Profile in Neonatal Coarctation Patients.

J Clin Med 2019 Apr 16;8(4). Epub 2019 Apr 16.

Bristol Heart Institute, Research Floor Level 7, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8HW, UK.

Coarctation of the aorta is a form of left ventricular outflow tract obstruction in paediatric patients that can be presented with either bicuspid (BAV) or normal tricuspid (TAV) aortic valve. The congenital BAV is associated with hemodynamic changes and can therefore trigger different molecular remodelling in the coarctation area. This study investigated the proteomic and phosphoproteomic changes associated with BAV for the first time in neonatal coarctation patients. Read More

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https://www.mdpi.com/2077-0383/8/4/517
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http://dx.doi.org/10.3390/jcm8040517DOI Listing
April 2019
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Synthesis and biological evaluation of pyrazolo[3,4-b]pyridine-3-yl pyrimidine derivatives as sGC stimulators for the treatment of pulmonary hypertension.

Eur J Med Chem 2019 Apr 10;173:107-116. Epub 2019 Apr 10.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China.

A series of new pyrazolo[3,4-b]pyridin-3-yl pyrimidine derivatives were synthesized and evaluated for the activation of sGC. Compared with riociguat, compound 13a exhibited equivalent in vitro activity on preconstricted rat thoracic aorta rings and in Rat heart Langendorff preparation. Compound 13a also showed acceptable PK profiles, which might become a promising candidate for the treatment of pulmonary hypertension. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.014DOI Listing

Study on neuroendocrine-immune function of Phenylethanoid Glycosides of Desertliving Cistanche herb in perimenopausal rat model.

J Ethnopharmacol 2019 Apr 14:111884. Epub 2019 Apr 14.

Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, 450008, China.

Ethnopharmacological Relevance: Desertliving Cistanche herb was first recorded in "Shen Nong'Herbal Classic" and listed as the top grade herbal medicine in it. Phenylethanoid glycosides are indicative components for identification and content determination of Desertliving Cistanche herb in Chinese pharmacopoeia, which is also one of the main active components. In this research, we explored the mechanism of phenylethanoid glycosides of Desertliving Cistanche herb to the perimenopausal model rats. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111884DOI Listing

Early results of a modified biological valved conduit for the Bentall procedure.

J Card Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Cardiac Surgery, The McGill University Health Center, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

Introduction: Few bioprosthetic valved conduits for aortic root surgery are commercially available. Long-term Warfarin therapy (mechanical), potential root calcification (xeno- or homograft valves), and the need for additional ascending aorta grafts are concerns associated with currently used valved conduits. A simplified, self-assembled bioroot conduit comprising currently available materials that facilitates future intervention and exhibits advantages of a bioprosthesis was used. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocs.14046
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http://dx.doi.org/10.1111/jocs.14046DOI Listing
April 2019
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Cardiovascular Disease: Cardioverter-Defibrillators and Left Ventricular Assist Devices.

FP Essent 2019 Apr;479:30-34

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Sudden cardiac death (SCD) is an abrupt and unexpected death presumed to be due to cardiac causes. The primary etiologic mechanism is cardiac arrest due to an arrhythmia. Cardioverter-defibrillators detect abnormal arrhythmia and abort the rhythm with an electrical shock. Read More

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April 2019
2 Reads

[Extra-anatomical bypass grafting of the thoracic aorta in a female patient with an infected pseudoaneurysm].

Angiol Sosud Khir 2019 ;25(1):169-174

Department of Aorta and Coronary Arteries Surgery, National Medical Research Centre named after Academician E.N. Meshalkin under the RF Ministry of Public Health, Novosibirsk, Russia.

Presented herein is the remote (more than 15-year follow up) result of successful surgical treatment of aortic coarctation complicated by septic aortitis and a false aneurysm of the anastomosis between the graft and the aortic arch. In 2002, after correction of aortic coarctation the woman was admitted to our Clinic with an incompetent proximal anastomosis and an infected aortic pseudoaneurysm. Taking into consideration the general and local septic process, repeat reconstruction of the thoracic aorta was impossible due to the risk for generalization of the infectious process and fatal complications. Read More

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http://dx.doi.org/10.33529/angio2019123DOI Listing
January 2019
1 Read

[Bleedings after reconstructive operations on the aorta, its branches, and peripheral arteries (on materials of the Department of Vascular Surgery A.N. Bakulev ICVS of the Academy of Medical Sciences of the USSR, 1961-1983)].

Angiol Sosud Khir 2019 ;25(1):143-150

A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Moscow, Russia.

The authors retrospectively analysed episodes of bleeding after reconstructive operations on the aorta, its branches, and peripheral arteries. The sources of information were the archival medical records of the Department of Vascular Surgery of formerly the Institute of Cardiovascular Surgery named after A.N. Read More

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http://dx.doi.org/10.33529/angio2019119DOI Listing
January 2019

[Use of topical haemostatic agents in cardiovascular surgery].

Angiol Sosud Khir 2019 ;25(1):131-142

Federal Centre of Cardiovascular Surgery under the RF Ministry of Public Health, Khabarovsk, Russia.

The problem of haemostasis in cardiovascular surgery is of current concern. Recent trends are towards increased use of topical haemostatic agents. Tachocomb has been used for more than 30 years in abdominal surgery and oncology. Read More

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https://elibrary.ru/item.asp?id=37004675
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http://dx.doi.org/10.33529/angio2019118DOI Listing
January 2019
2 Reads

[Choice of optimal treatment policy in patients with descending aortic dissection].

Angiol Sosud Khir 2019 ;25(1):115-119

Research Institute of Emergency Medicine named after N.V. Sklifosovsky under the Moscow Health Care Department, Moscow, Russia.

Contemporary approaches to treatment of patients with dissection of the descending aorta (DA), as well as the data of international registries and guidelines are contradictory. The endovascular method of treatment of patients with descending aortic dissection has been recognized to be revolutionary. However, there seems to be no commonly accepted concept concerning appropriate use of currently available techniques of treating patients with DA dissection. Read More

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http://dx.doi.org/10.33529/angio2019116DOI Listing
January 2019
2 Reads

A minimally invasive alternative for the treatment of nutcracker syndrome using individualized three-dimensional printed extravascular titanium stents.

Chin Med J (Engl) 2019 Apr 10. Epub 2019 Apr 10.

Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, China.

Background: This study was designed to evaluate the clinical and radiographic outcomes of patients with nutcracker syndrome (NCS) who were treated with three-dimensional printing (3DP) extravascular titanium stents (EVTSs). The 3DP EVTS was expected to release the hypertension of the left renal vein (LRV) produced by its compression between the superior mesenteric artery (SMA) and the aorta without causing any complications.

Method: The pre-operative kidney model of each patient was printed out to enable surgical planning. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000255DOI Listing

Dual-Source Computed Tomography of the Chest in Blunt Thoracic Trauma: Reduced Aortic Motion Using a Novel Temporal Resolution Optimization Method.

J Thorac Imaging 2019 Apr 15. Epub 2019 Apr 15.

Department of Radiology, Vancouver General Hospital, Vancouver, BC, Canada.

Purpose: The purpose of this study was to evaluate the clinical utility of temporal resolution optimization (TR-Opt), a computed tomography (CT) postprocessing technique, in reducing aortic motion artifacts in blunt thoracic trauma patients.

Materials And Methods: This was an IRB-approved study of 61 patients with blunt thoracic trauma carried out between February 18 and September 6, 2014; the patients had been imaged using a standardized dual-source high-pitch (DSHP) CT protocol. Image raw data were retrospectively postprocessed using the TR-Opt algorithm (DSHP-TR-Opt) and compared with conventional images (DSHP). Read More

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http://dx.doi.org/10.1097/RTI.0000000000000412DOI Listing

Microbiomes of Inflammatory Thoracic Aortic Aneurysms Due to Giant Cell Arteritis and Clinically Isolated Aortitis Differ From Those of Non-Inflammatory Aneurysms.

Pathog Immun 2019 15;4(1):105-123. Epub 2019 Mar 15.

Genomic Medicine Institute; Lerner Research Institute; Cleveland Clinic; Cleveland, Ohio.

Objective: We sought to characterize microbiomes of thoracic aortas from patients with non-infectious aortitis due to giant cell arteritis (GCA) and clinically isolated aortitis (CIA) and to compare them to non-inflammatory aorta aneurysm controls. We also compared microbiomes from concurrently processed and separately reported temporal arteries (TA) and aortas.

Methods: From 220 prospectively enrolled patients undergoing surgery for thoracic aorta aneurysm, 49 were selected. Read More

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http://dx.doi.org/10.20411/pai.v4i1.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438704PMC

Fracture of the Bare Spring of a Thoracic Endograft for Type A Aortic Dissection: A Case Report.

Vasc Specialist Int 2019 Mar;35(1):39-43

Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.

Retrograde type A aortic dissection (RTAD) following thoracic endovascular aortic repair is a devastating complication associated with high mortality rates. In particular, a deployed endograft in a bird-beak formation in an acute curve of the aortic arch can induce injury to the fragile aortic wall, with the subsequent development of RTAD. Here, we describe an extremely rare case of RTAD caused by fracture of the bare spring of the thoracic endograft for type A aortic dissection. Read More

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http://www.vsijournal.org/journal/DOIx.php?id=10.5758/vsi.20
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http://dx.doi.org/10.5758/vsi.2019.35.1.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453602PMC
March 2019
1 Read

Safety of EndoAnchors in real-world use: A report from the Manufacturer and User Facility Device Experience database.

Vascular 2019 Apr 16:1708538119844041. Epub 2019 Apr 16.

1 Division of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City, KS, USA.

Objectives: A hostile proximal neck anatomy is the most common cause of abdominal aorta endovascular aneurysm repair failure leading to a higher risk of device migration, proximal type I endoleak, and subsequent open surgical repair. Endostapling is a technique to attain better fixation of the endograft to the aortic wall, and the only available device in the USA is Aptus Heli-FX EndoAnchor system (Medtronic Vascular, Santa Rosa, CA, USA). Preliminary data have shown efficacy and safety of its use, and the aim of this study is to assess device-related adverse events in real-world clinical use. Read More

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http://dx.doi.org/10.1177/1708538119844041DOI Listing

Correlation between Aortic Calcification Score and Biochemical Parameters in Hemodialysis Patients.

Contrib Nephrol 2019 16;198:40-51. Epub 2019 Apr 16.

Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan,

Background: The purpose of this study was to determine the correlation between aortic calcification and demographic and biochemical parameters in hemodialysis patients.

Summary: Calcification scores of the aortic arch and abdominal aorta were determined from multi-slice computed tomography scans and evaluated according to the Agatston score. The associations between demographic and biochemical parameters and aortic calcification score were determined. Read More

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https://www.karger.com/Article/FullText/496717
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http://dx.doi.org/10.1159/000496717DOI Listing
April 2019
1 Read

Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?

Clin Sci (Lond) 2019 Apr 2;133(7):805-819. Epub 2019 Apr 2.

Department of Translational Medical Sciences, Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy.

Autophagy is a conserved process by which cytoplasmatic elements are sequestered in vesicles and degraded after their fusion with lysosomes, thus recycling the precursor molecules. The autophagy-mediated removal of redundant/harmful/damaged organelles and biomolecules plays not only a replenishing function, but protects against stressful conditions through an adaptive mechanism. Autophagy, known to play a role in several pathological conditions, is now gaining increasing attention also in the perspective of the identification of the pathogenetic mechanisms at the basis of ascending thoracic aortic aneurysm (TAA), a localized or diffused dilatation of the aorta with an abnormal widening greater than 50 percent of the vessel's normal diameter. Read More

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http://dx.doi.org/10.1042/CS20181092DOI Listing

Surgical correction of anomalous origin of the right coronary artery from the left sinus of Valsalva: How, where, and when.

Multimed Man Cardiothorac Surg 2019 Mar 5;2019. Epub 2019 Mar 5.

Cardiac Surgery Department San Raffaele University Hospital Milan, Italy.

Anomalous origin of the right coronary artery from the left sinus of Valsalva has a very low prevalence in the general population. Although the vast majority of patients are asymptomatic, the clinical consequence of this heart disorder can be sudden death. In many of these sudden death cases the right coronary artery is running between the anterior aspect of the aorta and behind the common trunk of the pulmonary artery, where systolic compression may have an impact on myocardial perfusion. Read More

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https://mmcts.org/tutorial/1199
Publisher Site
http://dx.doi.org/10.1510/mmcts.2019.005DOI Listing
March 2019
1 Read

[Preventive effect and mechanism of puerarin on rat models of disuse osteoporosis].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):535-540

Gansu University of Chinese Medicine Lanzhou 730000, China Department of Orthopedics, People's Liberation Army Joint Service Secuity Forces.No.940 Hospital Lanzhou 730050, China.

To investigate the preventive effect and possible mechanism of puerarin(Pur) in rat model of disuse osteoporosis(DOP),thirty healthy Wistar female rats of 2 months old were randomly divided into control group(Control), hindlimb suspension group(HLS), and puerarin group(HLS+Pur) in hindlimb suspension, with 10 rats in each group. A disuse osteoporosis model was established by tail suspension method, and 15.4 mg·kg~(-1) puerarin suspension was administered to HLS+Pur group every day, and the same volume of distilled water was administered to Control group and HLS group respectively. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181012.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181012.003DOI Listing
February 2019
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[Mechanism of inhibitory effect of catalpol on TNF-α induced HAECs cell damage].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(4):796-802

the Second Affiliated Hospital of Dalian Medical University Dalian 116023,China.

Catalpol is an iridoid glycoside extracted from the root of Rehmannia glutinosa. It has been reported to have antioxidant stress effects. Adenosine 5' monophosphate-activated protein kinase( AMPK) plays an important role in inhibiting oxidative stress. Read More

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http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181109.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181109.001DOI Listing
February 2019
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Large saccular aneurysm of the distal ascending aorta.

ANZ J Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiothoracic Surgery, The Prince Charles Hospital, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1111/ans.15137DOI Listing

Three-dimensional modeling of a Marfan syndrome with elastic and hyperelastic materials assumptions using fluid-structure interaction.

Biomed Mater Eng 2019 Apr 10. Epub 2019 Apr 10.

School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran.

Background: Marfan Syndrome (MFS) is a genetic disorder of the connective tissue. It most prominently influences the skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected as well.

Objective: This study aims to investigate a realistic three-dimensional model of an aorta of a specific patient suffering from MFS by considering elastic and hyperelastic materials for the tissue using fluid-structure interaction (FSI). Read More

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http://dx.doi.org/10.3233/BME-191049DOI Listing

Sphingosine-1-phosphate in Endothelial Cell Recellularization Improves Patency and Endothelialization of Decellularized Vascular Grafts In Vivo.

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Department of Pediatrics, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Background: S1P has been shown to improve the endothelialization of decellularized vascular grafts in vitro. Here, we evaluated the potential of tissue-engineered vascular grafts (TEVGs) constructed by ECs and S1P on decellularized vascular scaffolds in a rat model.

Methods: Rat aorta was decellularized mainly by 0. Read More

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http://dx.doi.org/10.3390/ijms20071641DOI Listing

Acute myocardial infarction as the first manifestation of Takayasu arteritis: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15143

Department of Cardiology, Zigong First People's Hospital, Zigong, Sichuan, PR China.

Rationale: Takayasu arteritis (TA) is a chronic inflammatory disease involving the aorta and its major branches. Initial diagnosis is usually difficult due to the highly variable symptoms. Acute myocardial infarction (AMI) is a very rare presentation in patients with TA. Read More

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http://dx.doi.org/10.1097/MD.0000000000015143DOI Listing
April 2019
2 Reads

Two episodes of remote ischemia preconditioning improve motor and sensory function of hind limbs after spinal cord ischemic injury.

J Spinal Cord Med 2019 Apr 15:1-10. Epub 2019 Apr 15.

b Department of Physiology, College of Medicine , Menoufia University , Shebeen Alkoom , Egypt.

Objectives: To investigate the effect of one and two remote ischemia preconditioning episodes (1-RIPC or 2-RIPC, respectively) on neuro-protection after spinal cord ischemic injury (SCI) in rats.

Design: Experimental animal study.

Setting: College of Medicine, King Khalid University, Abha, KSA. Read More

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http://dx.doi.org/10.1080/10790268.2019.1600829DOI Listing

Unique variation of the left testicular artery passing through a vascular hiatus in renal vein.

Anat Cell Biol 2019 Mar 29;52(1):105-107. Epub 2019 Mar 29.

Department of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, India.

Surgeons should have a thorough knowledge regarding the morphologic variations of the testicular arteries as any injury to this artery during surgery might cause testicular atrophy. We report in here an unusual course of left testicular artery and discuss its embryological basis and its clinical implications. The left testicular artery had a high origin from the anterior aspect of the abdominal aorta at the level of origin of renal artery. Read More

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http://dx.doi.org/10.5115/acb.2019.52.1.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449590PMC

Nerve distribution in myocardium including the atrial and ventricular septa in late stage human fetuses.

Anat Cell Biol 2019 Mar 29;52(1):48-56. Epub 2019 Mar 29.

Department of Anatomy and Institute of Medical Sciences, Chonbuk National University Medical School, Jeonju, Korea.

Few information had been reported on deep intracardiac nerves in the myocardium of late human fetuses such as nerves at the atrial-pulmonary vein junction and in the atrial and ventricular septa. We examined histological sections of the heart obtained from 12 human fetuses at 25-33 weeks. A high density of intracardiac nerves was evident around the mitral valve annulus in contrast to few nerves around the tricuspid annulus. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5115/acb.2019.52
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http://dx.doi.org/10.5115/acb.2019.52.1.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449578PMC
March 2019
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Unicentric Castleman's disease located between the aorta and inferior vena cava: A case report.

SAGE Open Med Case Rep 2019 3;7:2050313X19839532. Epub 2019 Apr 3.

Departments of Urology and Molecular Oncology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

We report a 70-year-old woman diagnosed with unicentric Castleman's disease with a contrast well-enhanced retroperitoneal tumor of 25 mm in diameter that located between the aorta and inferior vena cava. The imaging finding did not suggest any specific features, and no other lesion was detected. Laboratory examinations indicating malignant lymphoma such as soluble interleukin-2 were all negative. Read More

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http://dx.doi.org/10.1177/2050313X19839532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448118PMC
April 2019
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Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia.

Front Physiol 2019 28;10:277. Epub 2019 Mar 28.

Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States.

Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion. The main metabolite of FA, formate, was increased significantly in murine urine (∼3×) after overnight feeding. Because feeding increases mesenteric blood flow, we explored the direct effects of FA in isolated murine superior mesenteric artery (SMA). Read More

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http://dx.doi.org/10.3389/fphys.2019.00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448550PMC
March 2019
3 Reads

In-situ tissue classification during laser ablation using acoustic signals.

J Biophotonics 2019 Apr 14:e201800405. Epub 2019 Apr 14.

Department of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

We suggest a novel method to classify the type of tissue that is being ablated, using the recorded acoustic sound waves during pulsed UV laser ablation. The motivation of the current research is tissue classification during vascular interventions, where the identification of the ablated tissue is vital. We classify the acoustic signatures using Mel-frequency cepstral coefficients (MFCCs) feature extraction with a Support Vector Machine (SVM) algorithm, and in addition, use a fully connected deep neural network (FC-DNN) algorithm. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.2018004
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http://dx.doi.org/10.1002/jbio.201800405DOI Listing
April 2019
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Outcomes and Predictors of Endovascular Treatment for Type B Aortic Dissection Complicated by Unilateral Renal Ischemia.

J Vasc Interv Radiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, 180 Fenglin Road, 200032, Shanghai, China. Electronic address:

Purpose: This study investigated the outcomes of endovascular treatment for type B aortic dissection (TBAD) complicated by unilateral renal ischemia and determined the associated predictors.

Materials And Methods: From January 2010 to December 2016, 44 patients (mean : 54 years of age) with TBAD complicated by a clearly involved unilateral renal artery and a decreased mean density of the unilateral renal parenchyma were enrolled. The volumes and mean densities of each kidney were generated with postprocessing software based on computed tomography angiography. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.12.029DOI Listing

The Buffalo Trunk Technique for Aortic Arch Reconstruction.

Ann Thorac Surg 2019 Apr 11. Epub 2019 Apr 11.

Cardiothoracic Surgery Division, Department of Surgery, University of Colorado School of Medicine.

Background: The frozen elephant trunk technique facilitates repair of aortic arch and proximal descending aortic pathologies. Commercially available hybrid grafts may simplify this approach by allowing for a single suture line, potentially streamlining the distal anastomosis and improving operative times. However, these devices are currently not readily available in United States. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193051
Publisher Site
http://dx.doi.org/10.1016/j.athoracsur.2019.03.034DOI Listing
April 2019
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Vasodilatory effect of kaempferol-7-O-α-L-rhamnopyranoside via NO-cGMP-PKG signaling.

Arch Biochem Biophys 2019 Apr 11;667:1-5. Epub 2019 Apr 11.

Department of Physiology, College of Korean Medicine, Dongguk University, Gyeongju, South Korea; National Development Institute of Korean Medicine, Gyeongsan, Gyeongbuk, 712-210, South Korea. Electronic address:

Hypertension is one of the major causes of mortality. Though a host of drugs are available for the treatment of hypertension, majority have been linked to adverse side effects, necessitating the need for research into natural compounds with fewer side effects. Kaempferol-7-O-α-L-rhamnopyroside (KR) is a glycosylated flavone with neuroprotective and anti-inflammatory effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039861183096
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http://dx.doi.org/10.1016/j.abb.2019.04.001DOI Listing
April 2019
2 Reads