131,872 results match your criteria Anxiety Disorders


A relationship between weak attentional control and cognitive distortions, explained by negative affect.

PLoS One 2019 18;14(4):e0215399. Epub 2019 Apr 18.

Sabancı University, Istanbul, Turkey.

People high in negative affect (anxiety or depression) show cognitive distortions, specific thinking errors which contribute to the maintenance of their condition. It is thought that weak attentional control is a risk factor for negative affect and emotional disorders, because weak attentional control exaggerates the expression of attentional bias, another cognitive feature of emotional disorders. We wondered whether weak attentional control might similarly exaggerate the expression of cognitive distortions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215399PLOS

Disordered eating and the perinatal period: A systematic review and best evidence synthesis of mental health and psychosocial correlates.

Eur Eat Disord Rev 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychological Sciences, Swinburne University, Hawthorn, Melbourne, Australia.

Objective: This paper systematically reviews the literature to date on the relationship between disordered eating and mental health, psychological and social factors during pregnancy and the post-partum period, as well as the direction of associations.

Methods: Peer reviewed articles were sourced from seven databases: PsycINFO, CINAHL, Psychology and Behavioural Sciences Collection, Academic Search Complete, Scopus (MEDLINE), Web of Science, and Proquest. A quality review and best evidence synthesis was conducted. Read More

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http://dx.doi.org/10.1002/erv.2675DOI Listing

Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease.

J Neurol 2019 Apr 17. Epub 2019 Apr 17.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neurosciences, De Crespigny Park, London, SE5 8AF, UK.

Objective: To identify associated (non-)motor profiles of Parkinson's disease (PD) patients with hyperhidrosis as a dominant problem.

Methods: This is a cross-sectional, exploratory, analysis of participants enrolled in the Non-motor Longitudinal International Study (NILS; UKCRN No: 10084) at the Parkinson's Centre at King's College Hospital (London, UK). Hyperhidrosis scores (yes/no) on question 28 of the Non-Motor Symptom Questionnaire were used to classify patients with normal sweat function (n = 172) and excessive sweating (n = 56) (Analysis 1; n = 228). Read More

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http://dx.doi.org/10.1007/s00415-019-09325-wDOI Listing

Evaluation of affective temperament and anxiety-depression levels in fibromyalgia patients: a pilot study.

Braz J Psychiatry 2019 Apr 15. Epub 2019 Apr 15.

Başkent University School of Medicine, Psychiatry Department, Konya, Turkey.

Objective: Fibromyalgia (FM) patients have higher rates of depression and anxiety disorders than healthy controls. Affective temperament features are subclinical manifestations of mood disorders. Our aim was to evaluate the affective temperaments of FM patients and investigate their association with depression and anxiety levels and clinical findings. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1516-4446-2018-0057DOI Listing
April 2019
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The role of long-term psychodynamic psychotherapy in improving attachment patterns, defense styles, and alexithymia in patients with depressive/anxiety disorders.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):43-50. Epub 2019 Apr 11.

Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran.

Introduction: Long-term psychodynamic psychotherapy (LTPP) emphasizes the centrality of intrapsychic and unconscious conflicts and their relation to development. Although there is evidence supporting the efficacy of LTPP in mental disorders, little research has been published on the efficacy of LTPP for depressive and anxiety disorders.

Objective: To examine whether patients with anxiety and depressive disorders demonstrate improvement in their attachment styles, defense styles, psychiatric symptoms, anxiety/depressive symptoms, and alexithymia with LTPP. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/2237-6089-2017-0144DOI Listing
April 2019
1 Read

Dependency, mood instability, and inconsequence traits for discriminating borderline personality disorder.

Trends Psychiatry Psychother 2019 Jan-Mar;41(1):78-82. Epub 2019 Feb 28.

Programa de Pós-Graduação Stricto Sensu em Psicologia , Universidade São Francisco (USF), Campinas , SP , Brazil .

Introduction: Borderline personality disorder (BPD) is one of the most widely studied personality disorders (PDs). It recurrently shows traits of emotional lability, anxiety, separation insecurity, depressiveness, impulsiveness, risk exposure, and hostility, mainly affecting the domains of negative affectivity and antagonism.

Objectives: To investigate the most discriminant dimensions of the Dimensional Clinical Personality Inventory (Inventário Dimensional Clínico da Personalidade 2 [IDCP-2]) to distinguish people diagnosed with BPD from people without this diagnosis. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/2237-6089-2018-0010DOI Listing
February 2019
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Internet-Delivered Cognitive Behavioral Therapy for Anxiety Disorders in Open Community Versus Clinical Service Recruitment: Meta-Analysis.

J Med Internet Res 2019 Apr 17;21(4):e11706. Epub 2019 Apr 17.

Department of Clinical, Neuro and Developmental Psychology, VU University, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.

Background: Ample studies have shown the effectiveness of internet-delivered cognitive behavioral therapy (iCBT) for anxiety disorders. These studies recruited their participants mainly from the community and, to a lesser extent, from within routine care services. Little is known about whether different recruitment strategies lead to different treatment effects. Read More

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http://www.jmir.org/2019/4/e11706/
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http://dx.doi.org/10.2196/11706DOI Listing
April 2019
4 Reads

Emotion sensitivity and self-reported symptoms of generalized anxiety disorder across the lifespan: A population-based sample approach.

Brain Behav 2019 Apr 16:e01282. Epub 2019 Apr 16.

Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts.

Background: Individuals with generalized anxiety disorder (GAD) symptoms show deficits in emotion processing, but results of prior studies have been conflicting, and little is known about developmental trajectories of emotion processing over time. We examined the association between GAD symptoms and sensitivity to recognizing emotional facial expressions (emotion sensitivity: ES) for three emotions (happiness, anger, fear) in a large, diverse, population-based sample. We hypothesized that higher anxiety scores would be associated with poorer performance, and expected that ES performance and anxiety scores would decline across the lifespan. Read More

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http://dx.doi.org/10.1002/brb3.1282DOI Listing

Psychological disorders and quality of life in oral lichen planus patients and a control group.

Oral Dis 2019 Apr 16. Epub 2019 Apr 16.

Oral Medicine, Oral Surgery and Implantology Unit. Faculty of Medicine and Dentistry., Santiago de Compostela, Spain.

Objectives: oral lichen planus (OLP) is a common disease whose aetiopathogenesis is linked to psychological disorders. This study aims to determine the influence of anxiety and depression in OLP patients, define the perception of quality of life in these patients and check for potential differences between atrophic/ ulcerative and reticular lesions.

Material And Methods: a group of 48 OLP patients and a control group of 40 patients were selected. Read More

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http://dx.doi.org/10.1111/odi.13106DOI Listing

A study of psychiatric morbidity among school going adolescents.

Indian J Psychiatry 2019 Mar-Apr;61(2):198-203

Department of Community Medicine, GMC, Patiala, Punjab, India.

Aim: This study aims to study the prevalence of psychiatric morbidity among adolescents and compare its distribution in the urban and rural areas.

Study Design: This was a cross-sectional study.

Materials And Methods: One thousand adolescents aged 11 to 16 years studying in various private and government schools in urban and rural areas in district Patiala, Punjab were studied. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_35_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425794PMC
April 2019
1 Read

Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human.

Mol Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

Sackler Institute for Developmental Psychobiology, Weill Cornell Medicine, New York, NY, USA.

Social deficits are common in many psychiatric disorders. However, due to inadequate tools for manipulating circuit activity in humans and unspecific paradigms for modeling social behaviors in rodents, our understanding of the molecular and circuit mechanisms mediating social behaviors remains relatively limited. Using human functional neuroimaging and rodent fiber photometry, we identified a mOFC-BLA projection that modulates social approach behavior and influences susceptibility to social anxiety. Read More

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http://dx.doi.org/10.1038/s41380-019-0422-4DOI Listing

Low Zinc, Copper, and Manganese Intake is Associated with Depression and Anxiety Symptoms in the Japanese Working Population: Findings from the Eating Habit and Well-Being Study.

Nutrients 2019 Apr 15;11(4). Epub 2019 Apr 15.

Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

Epidemiological studies have suggested that there is an association between diet and mental health. The aim of this study was to investigate the association between the intake of six minerals and mental disorders in a cross-sectional study. We used data from the Eating Habit and Well-being study in Japanese workers. Read More

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http://dx.doi.org/10.3390/nu11040847DOI Listing

Assessing Costs Using the Treatment Inventory Cost in Psychiatric Patients (TIC-P), TIC-P Mini and TIC-P Midi.

J Ment Health Policy Econ 2019 Mar;22(1):15-24

Institute for Medical Technology Assessment (iMTA), Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, the Netherlands,

Background: The Treatment Inventory Cost in Psychiatric patients (TIC-P) instrument is designed to measure societal costs in patients with psychiatric disorders and to be applied in economic evaluations. Efforts have been made to minimize respondents' burden by reducing the number of questions and meanwhile retaining the comprehensiveness of the instrument. Previously, a TIC-P Mini version and a TIC-P Midi version were developed and tested in a predominantly inpatient patient population. Read More

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The impact of attention deficit hyperactivity disorder in obsessive-compulsive disorder subjects.

Depress Anxiety 2019 Apr 16. Epub 2019 Apr 16.

Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Background: Recent findings suggest an association between attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Thus, we evaluated the clinical associated features of ADHD in a large sample of adult OCD patients.

Methods: A cross-sectional study including 955 adult patients with OCD from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (C-TOC). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22898
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http://dx.doi.org/10.1002/da.22898DOI Listing
April 2019
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"Just keep pushing": parents' experiences of accessing child and adolescent mental health services for child anxiety problems.

Child Care Health Dev 2019 Apr 16. Epub 2019 Apr 16.

School of Psychology and Clinical Language Sciences, University of Reading, UK.

Background: Anxiety disorders are among the most common psychopathologies in childhood, however a high proportion of children with anxiety disorders do not access effective treatments. The aim of the present qualitative study was to understand families' experiences of seeking help and accessing specialist treatment for difficulties with childhood anxiety.

Methods: Parents of 16 children (aged 7-12 years) referred to a child mental health service for difficulties with anxiety, were interviewed about their experiences of seeking and accessing treatment within CAMHS. Read More

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http://dx.doi.org/10.1111/cch.12672DOI Listing
April 2019
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Work hazards and workers' mental health: an investigation based on the fifth European Working Conditions Survey.

Med Lav 2019 Apr 19;110(2):115-129. Epub 2019 Apr 19.

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Background: Workplace hazards are a significant source of health impairment for workers and of financial losses for firms. EU directives on workers' health and safety standards significantly contributed to reduce reported occupational injuries, yet the incidence and prevalence of work-related mental illness is still very high.

Objectives: We investigated the association between work-related hazards and individuals' perceived mental health. Read More

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http://dx.doi.org/10.23749/mdl.v110i2.7640DOI Listing

[Determinants of the quality of life of the hearing-impaired elderly].

Sante Publique 2019 November December;30(6):811-820

Aim: The aim of this paper is to assess the relationships between psycho-behavioral determinants and quality of life in individuals with age-related hearing loss.

Methods: This is a cross-sectional study performed in a French preventive health center, Marseille, France (Institut Régional d'Information et de Prévention de la Sénescence). The patients had a bilateral (mild to moderately severe) age-related hearing loss. Read More

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http://dx.doi.org/10.3917/spub.187.0811DOI Listing
April 2019
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Comorbidity in social anxiety disorder: diagnostic and therapeutic challenges.

Drugs Context 2019 2;8:212573. Epub 2019 Apr 2.

Department of Psychiatry, Istanbul Medical School, Istanbul University, Istanbul, Turkey.

Comorbid disorders are highly prevalent in patients with social anxiety disorder, occurring in as many as 90% of patients. The presence of comorbidity may affect the course of the disease in several ways such as comorbidity in patients with social anxiety disorder (SAD) is related to earlier treatment-seeking behavior, increased symptom severity, treatment resistance and decreased functioning. Moreover, comorbidities cause significant difficulties in nosology and diagnosis, and may cause treatment challenges. Read More

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http://dx.doi.org/10.7573/dic.212573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448478PMC

Psychiatric Disorders and Quality of Life in Egyptian Patients with Chronic Immune Thrombocytopenic Purpura: A Single Center Study.

Indian J Hematol Blood Transfus 2019 Apr 11;35(2):347-351. Epub 2018 Oct 11.

1Pediatrics Department, Faculty of Medicine, Mansoura University, Mansoura, 35516 Egypt.

The impact of chronic immune thrombocytopenic purpura (ITP) on the psychological health and quality of life is evident among children and adolescents. We aimed to describe psychological disorders and assess quality of life in children with chronic ITP and compared their results with their healthy peers. A cross-sectional comparative study was carried out in a tertiary care university-affiliated hospital during a period from November, 2015 till April, 2018. Read More

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http://dx.doi.org/10.1007/s12288-018-1031-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439116PMC

Pathogenesis and clinical features of the acute hepatic porphyrias (AHPs).

Mol Genet Metab 2019 Mar 6. Epub 2019 Mar 6.

Section on Gastroenterology & Hepatology, Wake Forest University School of Medicine/NC Baptist Hospital, Winston-Salem, NC 27157, United States of America.

The acute hepatic porphyrias include four disorders: acute intermittent porphyria [AIP], hereditary coproporphyria [HCP], variegate porphyria [VP], and the rare porphyria due to severe deficiency of ALA dehydratase [ADP]. In the USA, AIP is the most severe and most often symptomatic. AIP, HCP, and VP are due to autosomal dominant genetic abnormalities, in which missense, nonsense, or other mutations of genes of normal hepatic heme biosynthesis, in concert with other environmental, nutritional, hormonal and genetic factors, may lead to a critical deficiency of heme, the end-product of the pathway, in a small but critical 'regulatory pool' within hepatocytes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192193008
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http://dx.doi.org/10.1016/j.ymgme.2019.03.002DOI Listing
March 2019
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Efficacy and mechanisms of non-invasive brain stimulation to enhance exposure therapy: A review.

Clin Psychol Rev 2019 Apr 6;70:64-78. Epub 2019 Apr 6.

Northwestern University, United States.

Though cognitive behavioral techniques are generally effective in the treatment of anxiety disorders, some people fail to benefit from exposure therapy or experience a return of fear after terminating exposure therapy. The burgeoning field of non-invasive brain stimulation provides a potential method of augmenting exposure therapy so that it is more effective. Successful exposure therapy is hypothesized to occur due to inhibition, and research suggests that brain stimulation can alter inhibitory learning and related processes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02727358183049
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http://dx.doi.org/10.1016/j.cpr.2019.04.001DOI Listing
April 2019
1 Read

Comparison and change of defense mechanisms over the course of psychotherapy in patients with depression or anxiety disorder: Evidence from a randomized controlled trial.

J Affect Disord 2019 Apr 8;252:212-220. Epub 2019 Apr 8.

Department of Clinical Psychology and Psychotherapy, University of Bern, Fabrikstrasse 8, 3012 Bern, Switzerland.

Background: Defense mechanisms play an important role in the development and maintenance of both health and psychopathology. Research is still in the early stages of investigating the specific relationships among diagnostic groups and defense mechanisms along with their response to different treatment types.

Methods: For the present study a total of 47 outpatients diagnosed with depression or anxiety disorders were randomized to receive 25±3 sessions of cognitive-behavioral therapy with integrated elements of either emotion-focused therapy (CBT + EFT) or treatment components based on self-regulation theory (CBT + SR). Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.021DOI Listing

Childhood maltreatment, vulnerability characteristics and adult incident common mental disorders: 3-year longitudinal data among >10,000 adults in the general population.

J Psychiatr Res 2019 Mar 30;113:199-207. Epub 2019 Mar 30.

Department of Psychiatry and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands.

Childhood maltreatment (CM) is a strong predictor of incident (first-onset and recurrent) mental disorders in adulthood. However, less is known about underlying mechanisms and moderators of these associations. This study examines to what extent vulnerability characteristics (low social support, negative life events, parental psychopathology, neuroticism, history and comorbidity of mental and physical health) contribute to the impact of CM on adult psychopathology. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.03.029DOI Listing

Measuring treatment outcome in patients with anxiety disorders: A comparison of the responsiveness of generic and disorder-specific instruments.

J Anxiety Disord 2019 Apr 6;64:55-63. Epub 2019 Apr 6.

Institute of Psychology, Faculty of Social Sciences, Leiden University, Pieter De La Court Building, P.O. Box 9555, 2300 RB Leiden, the Netherlands; Stichting Benchmark GGZ, Rembrandtlaan 46, 3723 BK Bilthoven, the Netherlands. Electronic address:

Background: For routine outcome monitoring, generic (i.e., broad-based) and disorder-specific instruments are used to monitor patient progress. Read More

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http://dx.doi.org/10.1016/j.janxdis.2019.04.001DOI Listing

Prospects for reconsolidation-focused treatments of substance use and anxiety-related disorders.

Curr Opin Psychol 2019 Mar 13;30:80-86. Epub 2019 Mar 13.

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina Charleston, SC, USA. Electronic address:

Memories are often conceptualized as permanent entities; however, retrieval of memories via stimulus prompts can return them to an active state, which initiates a period of lability before the memories are reconsolidated into long-term storage. Importantly, during this period, memories can be disrupted/altered. A growing body of work has focused on translating animal and experimental science into reconsolidation-based interventions for clinical disorders maintained by maladaptive memories. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2352250X183027
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http://dx.doi.org/10.1016/j.copsyc.2019.03.001DOI Listing
March 2019
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The effect of transcutaneous vagus nerve stimulation on fear generalization and subsequent fear extinction.

Neurobiol Learn Mem 2019 Apr 12. Epub 2019 Apr 12.

Institute of Psychology, Leiden University, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands.

Fear overgeneralization is thought to be one of the cardinal processes underlying anxiety disorders, and a determinant of the onset, maintenance and recurrence of these disorders. Animal studies have shown that stimulating the vagus nerve (VNS) affects neuronal pathways implicated in pattern separation and completion, suggesting it may reduce the generalization of a fear memory to novel situations. In a one-day study, 58 healthy students were subjected to a fear conditioning, fear generalization, and fear extinction paradigm. Read More

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http://dx.doi.org/10.1016/j.nlm.2019.04.006DOI Listing

Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

School of Life Sciences, Guangzhou University, Guangzhou, 510006, China. Electronic address:

Citalopram (CTM), a selective serotonin reuptake inhibitor (SSRI), has been widely used to treat panic disorders, such as depression which is one of the most disabling, yet common, psychiatric disorders. Although prenatal antidepressant exposure has a major impact on the neurobehavioral development of the offspring, such as anxiety, depression- and autism-like behaviors, the brain alterations of SSRI influence remained largely unknown. We show here, using electrophysiological recordings, that CTM exposure during the last 7 d of gestation can alter theta- and gamma-band oscillation and synchronization in the corticostriatal loop of 2-3 month-old mouse offspring. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.008DOI Listing

ADHD in adults: clinical subtypes and associated characteristics.

Riv Psichiatr 2019 Mar-Apr;54(2):84-89

Dipartimento di Salute Mentale e Dipendenze, ASST Fatebenefratelli-Sacco, Milan, Italy.

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is an early onset clinical condition characterized by attention difficulties, hyperactivity and impulsivity which can persist across the lifespan, significantly influencing the evolutionary course and facilitating the rise of psychiatric comorbidities. The presence of different ADHD subtypes in adults is a heterogeneity factor to be recognized in order to orient prognosis and treatment, as indicated by studies that described differences in the characterization of different subtypes in relation to both severity and comorbidities.

Materials And Methods: In the present study we evaluated the socio-demographic and clinical characteristics of a sample of adults with ADHD and the characteristics associated with the different disorder subtypes. Read More

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http://www.rivistadipsichiatria.it/articoli.php?archivio=yes
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http://dx.doi.org/10.1708/3142.31249DOI Listing
April 2019
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The central role of psychopathology and its association with disease severity in inflammatory bowel disease and irritable bowel syndrome.

Riv Psichiatr 2019 Mar-Apr;54(2):75-83

Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, Sapienza University of Rome, Italy - Department of Gastroenterology, Humanitas Clinical Institute, Rozzano (Milan), Italy.

Background: Biopsychosocial models for both organic and functional gastrointestinal (GI) disorders can be found in the literature. To clarify the role of psychopathological factors and their relationship with GI symptom severity, several studies have examined them in inflammatory bowel disease (IBD) - occasionally distinguishing between ulcerative colitis (UC) and Crohn's disease (CD) - and in irritable bowel syndrome (IBS), leading to unclear results.

Aims: We aimed to evaluate the psychopathological features of IBD and IBS patients in comparison with healthy individuals and assess the association with disease severity. Read More

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http://dx.doi.org/10.1708/3142.31248DOI Listing

Novel Risk Factors for Posttraumatic Stress Disorder Symptoms in Family Members of Acute Respiratory Distress Syndrome Survivors.

Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA.

Objectives: Family members of ICU survivors report long-term psychologic symptoms of posttraumatic stress disorder. We describe patient- and family-member risk factors for posttraumatic stress disorder symptoms among family members of survivors of acute respiratory distress syndrome.

Design: Prospective cohort study of family members of acute respiratory distress syndrome survivors. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003774DOI Listing

Hypertensive Disorders of Pregnancy and Symptoms of Depression and Anxiety as Related to Gestational Age at Birth: Findings from the All Our Families Study.

Psychosom Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychology, Faculty of Science, McGill University (Kristin Horsley and Blaine Ditto); Department of Psychology, Faculty of Arts, University of Calgary (Lianne Tomfohr-Madsen); Department of Pediatrics and Community Health Sciences, Cumming School of Medicine (Suzanne Tough).

Objective: To investigate whether symptoms of depression or state anxiety changed the strength or nature of the association between hypertensive disorders of pregnancy (HDP) and gestational age at birth.

Methods: We conducted a secondary analysis of data from the All Our Families Cohort, a prospective pregnancy cohort study based in Calgary, Alberta, Canada. Self-reported depressive symptoms and state anxiety were assessed between three- and five-months' gestation, and obstetrical information including diagnosis of HDP, parity, type of delivery, and gestational age at birth was retrieved from the maternal discharge abstract. Read More

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http://dx.doi.org/10.1097/PSY.0000000000000695DOI Listing

Understanding User Experience: Exploring Participants' Messages With a Web-Based Behavioral Health Intervention for Adolescents With Chronic Pain.

J Med Internet Res 2019 Apr 15;21(4):e11756. Epub 2019 Apr 15.

Department of Anesthesiology and Pain Medicine, School of Medicine, University of Washington, Seattle, WA, United States.

Background: Delivery of behavioral health interventions on the internet offers many benefits, including accessibility, cost-effectiveness, convenience, and anonymity. In recent years, an increased number of internet interventions have been developed, targeting a range of conditions and behaviors, including depression, pain, anxiety, sleep disturbance, and eating disorders. Human support (coaching) is a common component of internet interventions that is intended to boost engagement; however, little is known about how participants interact with coaches and how this may relate to their experience with the intervention. Read More

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http://dx.doi.org/10.2196/11756DOI Listing
April 2019
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Symptom shifting and associations with mental illness: A transdiagnostic approach applied to eating disorders.

J Abnorm Psychol 2019 Apr 15. Epub 2019 Apr 15.

Centre for Psychiatry Research.

Diagnostic comorbidity is common among psychiatric patients. One approach to obtain an improved understanding of this phenomenon is to explore diagnostic transitions, across time. In the present study, we aim to take this methodology further within the specific context of eating disorders by investigating whether there are individuals who shift not only between different eating disorder symptoms, but also shift to deliberate self-harm and substance use over time, and relations of this to other indicators of mental illness. Read More

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http://dx.doi.org/10.1037/abn0000425DOI Listing

Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.

Genes Brain Behav 2019 Apr 15:e12570. Epub 2019 Apr 15.

Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, North Carolina.

Genome-wide association studies linked diacylglycerol kinase eta (DGKH) and iota (DGKI) to mood disorders, including bipolar disorder and schizophrenia, and both genes are expressed throughout the brain. Here, we generated and behaviorally characterized female mice lacking Dgkh alone, Dgki alone, and double Dgkh/Dgki knockout (dKO) mice. We found that fewer than 30% of newborn pups raised by dKO females survived to weaning, while over 85% of pups survive to weaning when raised by wild type (WT) females. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gbb.12570
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http://dx.doi.org/10.1111/gbb.12570DOI Listing
April 2019
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Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation.

Biomed Res Int 2019 11;2019:3102414. Epub 2019 Mar 11.

Department of Nursing, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan.

Etifoxine, an 18 kDa translocator protein (TSPO) agonist for the treatment of anxiety disorders in clinic, may be able to cause acute liver injury or cytolytic hepatitis. TSPO has been demonstrated to participate in inflammatory responses in infective diseases as well as to modulate glucose and lipid homeostasis. Hepatitis C virus (HCV) infection disrupts glucose and lipid homoeostasis, leading to insulin resistance (IR). Read More

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https://www.hindawi.com/journals/bmri/2019/3102414/
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http://dx.doi.org/10.1155/2019/3102414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432734PMC
March 2019
1 Read

The Vessels Shaping Mental Health or Illness.

Open Neurol J 2019 15;13:1-9. Epub 2019 Feb 15.

Department of Psychiatry, Harvard Medical School, Boston, MA-02215, USA.

The mammalian brain receives the lion's share of the body's blood supply and is a highly vascularized organ. The vascular and nervous systems arise at two distinct time points of embryogenesis; however, their functions tend to overlap or complement each other in the growth promoting milieu of the embryonic Central Nervous System (CNS). The pre-existing idea that mental disorders are a direct result from defects solely in neuronal populations and networks is gradually changing. Read More

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http://dx.doi.org/10.2174/1874205X01913010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460472PMC
February 2019

Identification of a Functional Non-coding Variant in the GABA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research.

Front Genet 2019 29;10:188. Epub 2019 Mar 29.

Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. expression varies as a function of genotype and is modulated by sequence variants in several brain structures and populations, including F2 crosses originating from C57BL/6J (B6J) and the BXD recombinant inbred family derived from B6J and DBA/2J. Read More

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http://dx.doi.org/10.3389/fgene.2019.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449455PMC

In the Absence of Effects: An Individual Patient Data Meta-Analysis of Non-response and Its Predictors in Internet-Based Cognitive Behavior Therapy.

Front Psychol 2019 29;10:589. Epub 2019 Mar 29.

Department of Psychology, Stockholm University, Stockholm, Sweden.

Negative effects of psychological treatments have recently received increased attention in both research and clinical practice. Most investigations have focused on determining the occurrence and characteristics of deterioration and other adverse and unwanted events, such as interpersonal issues, indicating that patients quite frequently experience such incidents in treatment. However, non-response is also negative if it might have prolonged an ongoing condition and caused unnecessary suffering. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450428PMC

Editorial: Brain and Somatization Symptoms in Psychiatric Disorders.

Front Psychiatry 2019 28;10:146. Epub 2019 Mar 28.

Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China.

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00146
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http://dx.doi.org/10.3389/fpsyt.2019.00146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447705PMC
March 2019
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The Role of the Rodent Insula in Anxiety.

Front Physiol 2019 29;10:330. Epub 2019 Mar 29.

Laboratorio de Neurobiología, Instituto de Ciencias Biomédicas, Facultad de Medicina y Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.

The human insula has been consistently reported to be overactivated in all anxiety disorders, activation which has been suggested to be proportional to the level of anxiety and shown to decrease with effective anxiolytic treatment. Nonetheless, studies evaluating the direct role of the insula in anxiety are lacking. Here, we set out to investigate the role of the rodent insula in anxiety by either inactivating different insular regions via microinjections of glutamatergic AMPA receptor antagonist CNQX or activating them by microinjection of GABA receptor antagonist bicuculline in rats, before measuring anxiety-like behavior using the elevated plus maze. Read More

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http://dx.doi.org/10.3389/fphys.2019.00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450210PMC

Hypochondriasis: Clinical Profile in a Tertiary Care Psychiatry and Neurosciences Hospital in Southern India - A Retrospective Chart Review.

Indian J Psychol Med 2019 Mar-Apr;41(2):178-181

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background: Hypochondriasis is a complex disorder in the realm of psychosomatic medicine, yet understudied in India. The aim of this study was to assess the clinical profile of patients diagnosed with hypochondriasis.

Materials And Methods: Retrospective chart review was done in a tertiary care psychiatry and neurosciences hospital in southern India. Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_177_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436408PMC

"I'm scared": Journaling Uncovers Student Perceptions Prior to a Psychiatric Clinical Rotation.

J Am Psychiatr Nurses Assoc 2019 Apr 15:1078390319844002. Epub 2019 Apr 15.

3 Johnny R. Tice, DNP, MA, CRNP, FNP-C, PMHNP-BC, The University of Alabama, Tuscaloosa, AL, USA.

Background: The United States is experiencing a shortage of mental health practitioners. A growing body of evidence shows that nursing students state that mental health is among the least desirable specialties, citing anxiety as a prominent factor. This study builds on existing knowledge and seeks to understand undergraduate nursing students' goals and perceptions about mental health prior to a mental health course utilizing a semistructured clinical journal. Read More

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http://dx.doi.org/10.1177/1078390319844002DOI Listing
April 2019
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The relationship of hyperemesis gravidarum with sleep disorders, anxiety and depression.

J Obstet Gynaecol 2019 Apr 15:1-6. Epub 2019 Apr 15.

b Department of Biostatistics, Faculty of Medicine , Hitit University , Çorum , Turkey.

The purpose of this study was to compare patients who were diagnosed with hyperemesis gravidarum (HG) with the control group by identifying anxiety, depression, sleep disorder levels and the relationship between them. This study involved 98 first-trimester pregnant women (46 HG patients and 52 control group patients) who applied to the Hitit University Medicine Faculty Obstetrics and Gynecology clinic. Statistically significant differences were found between HG patients and the control group according to the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores (p < . Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1572725DOI Listing
April 2019
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[Syndrome de l'intestin irritable : de la comorbidité anxiodépressive au microbiote].

Authors:
Guillaume Fond

Rev Prat 2019 Feb;69(2):219-220

Université Aix- Marseille, faculté de médecine, secteur La Timone, EA 3279 : CEReSS (Centre d'étude et de recherche sur les services de santé et la qualité de vie), Marseille, France.

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February 2019
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Revalidation of Adjustment Disorder-New Module-4 screening of adjustment disorder in a non-clinical sample: Psychometric reevaluation and correlates with other ICD-11 mental disorders.

Psych J 2019 Apr 15. Epub 2019 Apr 15.

School of Social Work, Ariel University, Ariel, Israel.

In line with the new conceptualization of adjustment disorder (AjD) in the 11th revision of the International Classification of Diseases (ICD-11), a new 20-item self-report questionnaire was developed and validated - the Adjustment Disorder-New Module (ADNM). However, such a long research tool has the potential to become problematic for use in epidemiological and clinical settings. Therefore, an ultra-brief measure for AjD (ADNM-4) was established and validated in a recent study conducted with a representative national sample. Read More

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http://dx.doi.org/10.1002/pchj.286DOI Listing

Predictive Associations Among the Repeated Measurements of Anxiety, Depression, and Craving in a Dual Diagnosis Program.

J Dual Diagn 2019 Apr 14:1-7. Epub 2019 Apr 14.

b Department of Psychiatry and Biobehavioral Sciences , University of California-Los Angeles, The Camden Center , Los Angeles , California , USA.

Objective: Anxiety and depression commonly co-occur with substance use disorders. Conceptual models would presume that changes in anxiety and depression should lead to changes in drug and alcohol craving during treatment for co-occurring disorders, but no longitudinal investigation has explored this assumption. This study examined the associations among craving, anxiety, and depression in a dual diagnosis program. Read More

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http://dx.doi.org/10.1080/15504263.2019.1589660DOI Listing

Headaches and sleep problems in US adolescents: Findings from the National Comorbidity Survey - Adolescent Supplement (NCS-A).

Cephalalgia 2019 Apr 13:333102419835466. Epub 2019 Apr 13.

1 Genetic Epidemiology Branch, National Institute of Mental Health, Bethesda, MD, USA.

Background: There is limited research on the association of sleep problems with International Classification of Headache Disorders (ICHD-II)-defined headache subtypes in youth, particularly from community-based samples. This cross-sectional study examines the associations of sleep patterns, symptoms and disorders with specific headache subtypes among adolescents from the general population of the United States.

Methods: The sample includes 10,123 adolescents in the National Comorbidity Survey - Adolescent Supplement, a face-to-face survey of adolescents aged 13-18 years in the continental USA. Read More

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http://dx.doi.org/10.1177/0333102419835466DOI Listing
April 2019
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Effectiveness of mindfulness-based cognitive therapy for comorbid depression and anxiety in pregnancy: a randomized controlled trial.

Arch Womens Ment Health 2019 Apr 13. Epub 2019 Apr 13.

Department of Clinical Psychology, University of Kurdistan, Sanandaj, Iran.

Pregnant women are at high risk of mood and anxiety disorders, and options for non-pharmacological treatment are limited. Mindfulness-based cognitive therapy (MBCT) has strong evidence among people with mood and anxiety disorders, but limited studies reported the effectiveness of MBCT on perinatal comorbid conditions. This study aimed to examine the effects of an 8-week MBCT intervention on pregnant women with comorbid depression and anxiety. Read More

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http://dx.doi.org/10.1007/s00737-019-00962-8DOI Listing

HPA axis regulation and stress response is subject to intergenerational modification by paternal trauma and stress.

Gen Comp Endocrinol 2019 Apr 11. Epub 2019 Apr 11.

Department of Anatomy & Neuroscience, University of Melbourne, VIC 3010, Australia; Florey Institute of Neurosciences and Mental Health, University of Melbourne, VIC 3010, Australia. Electronic address:

There is increasing evidence that one's risk for psychiatric disturbances and metabolic syndromes is influenced by their parents' own health history, lifestyle and living environment. For example, paternal high fat diet is strongly linked to neuroendocrine dysregulation in offspring and increased risk for diabetes. The potential intergenerational impact of paternal stress has only just begun to emerge, with the initial evidence suggestive of greater risk for anxiety-related disorders. Read More

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http://dx.doi.org/10.1016/j.ygcen.2019.04.010DOI Listing
April 2019
1 Read