130,635 results match your criteria Anxiety Disorders


Man and the Microbiome: A New Theory of Everything?

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Departments of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 K8AF, Ireland; email:

The gut microbiome is implicated in the pathophysiology of a wide range of psychological disorders. Preclinical studies have provided us with key insights into the mechanisms by which the microbiome influences bidirectional gut-brain communication. There are many signaling pathways involved, including the hypothalamic-pituitary-adrenal axis, immune modulation, tryptophan and serotonin metabolism, bile acid transformation, microbial production of neuroactive compounds, and regulation of the endocannabinoid system. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095432DOI Listing
February 2019
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Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study.

J Clin Psychiatry 2019 Feb 19;80(2). Epub 2019 Feb 19.

Bipolar Disorder Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR).

Methods: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Read More

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https://www.psychiatrist.com/JCP/article/Pages/2019/v80/17m1
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http://dx.doi.org/10.4088/JCP.17m12082DOI Listing
February 2019
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Psychotropic medication use trends in a large pediatric and young adult solid organ transplant population.

Pediatr Transplant 2019 Feb 20:e13380. Epub 2019 Feb 20.

Boston Children's Hospital Department of Psychiatry, Boston, Massachusetts.

Introduction: This study describes psychotropic medication use in a pediatric and young adult solid organ transplant population.

Methods: We conducted a retrospective review of the lifetime incidence of psychotropic medication use and associated characteristics in patients seen over a 6-year period at a large pediatric transplant center utilizing univariate and multivariate statistical analyses.

Results: The lifetime incidence of psychotropic medication use was 36. Read More

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http://dx.doi.org/10.1111/petr.13380DOI Listing
February 2019

[Epidemiological study of mental health in the general population of Argentina].

Vertex 2018 Nov;XXIX(142):275-299

Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

In this paper we report the findings of the first "Epidemiological study of mental health in the general population of Argentina" in the framework of the World Mental Health Survey Initiative WHO / Harvard, in collaboration with the Faculty of Medicine of the University of Buenos Aires and the Asociación de Psiquiatras Argentinos (APSA) with funding from the Ministry of Health. Methodology: A multistage probabilistic household survey was conducted using the Composite International Diagnostic Interview (CIDI). The survey was conducted on 3,927 people aged 18 and over (no age limit), with fixed residence in one of the eight largest urban areas in the country (Buenos Aires, Córdoba, Corrientes-Resistencia, Mendoza, Neuquén, Rosario, Salta and Tucumán), representing approximately 50. Read More

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November 2018

A role for the microbiome in mother-infant interaction and perinatal depression.

Int Rev Psychiatry 2019 Feb 20:1-15. Epub 2019 Feb 20.

a Department of Psychiatry , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.

Perinatal depression is a significant public health problem, due to its negative impact on maternal well-being and long-term adverse effects for children. Mother-infant interaction and maternal responsiveness and sensitivity are a hypothesized mechanism by which perinatal depression effects child development, and increasing research in the microbiota-gut-brain axis may provide a new avenue of investigation. There is limited efficacy for treatment of perinatal depression for improving the mother-infant relationship and child outcomes. Read More

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http://dx.doi.org/10.1080/09540261.2018.1548431DOI Listing
February 2019

Prognostic Risk Models for the Development of Cardiovascular Dysfunction in Adolescents with Essential Hypertension.

Bull Exp Biol Med 2019 Feb 19. Epub 2019 Feb 19.

Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.

We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene ARA2A (-1291С>G), norepinephrine transporter NET (-1287G>A), and D2-dopamine receptor DRD2 (-141C Ins/Del) and the data of psychological testing. Read More

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http://dx.doi.org/10.1007/s10517-019-04380-9DOI Listing
February 2019

Occupational well-being in pediatricians-a survey about work-related posttraumatic stress, depression, and anxiety.

Eur J Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Obstetrics and Gynecology, OLVG, Oosterpark 9, 1091 AC, Amsterdam, The Netherlands.

The objective of this study was to study mental health, coping, and support after work-related adverse events among pediatricians. Physicians are frequently exposed to adverse events. It makes them at risk for posttraumatic stress disorder (PTSD), depression, and anxiety disorders. Read More

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http://dx.doi.org/10.1007/s00431-019-03334-7DOI Listing
February 2019

Impact of a specific training programme on the neuromodulation of pain in female patient with fibromyalgia (DouFiSport): a 24-month, controlled, randomised, double-blind protocol.

BMJ Open 2019 Jan 25;9(1):e023742. Epub 2019 Jan 25.

LIEN, EA4685, University of Western Brittany (UBO), Brest, France.

Introduction: The main symptom of fibromyalgia (FM) is diffuse pain. There is currently no aetiological treatment for FM. However, all pain associations and best practice guidelines strongly advocate the practice of aerobic physical activity to improve the symptoms of FM subjects. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023742DOI Listing
January 2019

Psychotic experiences in the context of mood and anxiety disorders and their associations with health outcomes among people of color in the United States.

J Psychosom Res 2019 Mar 17;118:27-33. Epub 2019 Jan 17.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain. Electronic address:

Background: Psychotic experiences appear to increase risk for health outcomes above and beyond mood/anxiety disorders. However, existing studies that have found this association were conducted mostly in low- and middle-income countries, calling for more studies to explore the association in other contexts, such as the U.S. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.01.004DOI Listing

A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.

Post-traumatic stress disorder (PTSD) is an acquired psychiatric disorder with functionally impairing physiological and psychological symptoms following a traumatic exposure. Genetic, epigenetic, and environmental factors act together to determine both an individual's susceptibility to PTSD and its clinical phenotype. In this literature review, we briefly review the candidate genes that have been implicated in the development and severity of the PTSD phenotype. Read More

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http://dx.doi.org/10.3390/genes10020140DOI Listing
February 2019

The Effect of the Treatment at a Pain Clinic on the Patients' Assessment of Their Pain Intensity and the Incidence of Mental Disorders in the form of Anxiety, Depression, and Aggression.

Int J Environ Res Public Health 2019 Feb 18;16(4). Epub 2019 Feb 18.

Department of Anesthesiology and Intensive Care, John Paul II Western Hospital in Grodzisk Mazowiecki, 11 Daleka St., 05-825 Grodzisk Mazowiecki, Poland.

The aim of the study was to analyze the effect of the treatment given to patients in a pain clinic on their assessment of pain intensity and the incidence of emotional disturbances in the form of anxiety, depression, and aggression. The study was conducted from January 2014 to April 2018 among patients under the care of two Warsaw pain clinics. The study tools were the Hospital Anxiety and Depression Scale-Modified Version (HADS-M) and the Numerical Rating Scale (NRS). Read More

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http://dx.doi.org/10.3390/ijerph16040586DOI Listing
February 2019
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The influence of attachment style and relationship quality on quality of life and psychological distress in carers of people with epileptic and nonepileptic seizures.

Epilepsy Behav 2019 Feb 16;93:16-21. Epub 2019 Feb 16.

Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom; Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.

Background: Seizure disorders affect not only the individual living with seizures, but also those caring for them. Carer-patient relationships may be influenced by, and have an influence on, some aspects of living with seizure disorders - with potentially different interactions seen in epilepsy and psychogenic nonepileptic seizures (PNES).

Objectives: We studied the influence of patient and carer attachment style and relationship quality on carer wellbeing and psychological distress, and explored whether these associations differ between carers for people with epilepsy and for those with PNES. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.028DOI Listing
February 2019

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene.

Pharmacol Biochem Behav 2019 Feb 16. Epub 2019 Feb 16.

Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:

In humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysfunctions of the dopamine system. Here we asked, whether the DISC1 overexpression affects locomotor activity in the open field (OF), anxiety in the elevated plus-maze (EPM), depression-related behavior in the forced swim test (FST), and attention-like/short-term working-memory in the spontaneous alternation behavior (SAB) in the T-maze in transgenic DISC1 (tgDISC1) rats and littermate controls (WT). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.005DOI Listing
February 2019

Treating comorbid depression and avoidant personality disorder: The case of Andy.

J Clin Psychol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, Institute of Psychotherapy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Major depressive disorder is among the most frequently diagnosed mental disorders and is often accompanied by other disorders such as anxiety or substance abuse. As a result of a complicated tangle of comorbidities, psychotherapy in such cases can become quite demanding. The present case study presents and discusses the challenges represented by a complex case of psychotherapy, focusing on ongoing modifications of the clinical hypotheses and therapeutic approach. Read More

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http://dx.doi.org/10.1002/jclp.22764DOI Listing
February 2019

Predictors of Adverse Alcohol Use Consequences Among Tertiary Students.

Alcohol Clin Exp Res 2019 Feb 19. Epub 2019 Feb 19.

Melbourne School of Psychological Sciences, University of Melbourne, Parkville, 3010, VIC, Australia.

Background: The alcohol consumption patterns of young adults are of concern. Critically, tertiary students consume greater quantities of alcohol, are at increased risk of injury/harm, and have higher rates of alcohol use disorders (AUD) as compared to their non-university enrolled peers. The Brief Young Adult Alcohol Consequences Questionnaire (BYAACQ) is one of several tools utilised to explore adverse alcohol-related outcomes among tertiary students. Read More

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http://doi.wiley.com/10.1111/acer.13988
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http://dx.doi.org/10.1111/acer.13988DOI Listing
February 2019
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The experience of intolerance of uncertainty for young people with a restrictive eating disorder: a pilot study.

Eat Weight Disord 2019 Feb 16. Epub 2019 Feb 16.

Maudsley Centre for Child and Adolescent Eating Disorders, South London and Maudsley NHS Foundation Trust, London, UK.

Purpose: Research is consistently reporting elevated levels of intolerance of uncertainty (IU) in individuals with an eating disorder (ED). Less is known about the phenomenology of uncertainty for this clinical group. The present study aims to advance our understanding of the relationship between IU and restrictive EDs by providing insight into young people's subjective experiences of uncertainty. Read More

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http://dx.doi.org/10.1007/s40519-019-00652-5DOI Listing
February 2019

Network Analysis of Behaviors in the Depression and Autism Realms: Inter-Relationships and Clinical Implications.

J Autism Dev Disord 2019 Feb 18. Epub 2019 Feb 18.

Child Study Center, Yale University School of Medicine, 230 S. Frontage Rd, New Haven, CT, 06519, USA.

Depression-, anxiety-, OCD- and autism-related behaviors were assessed in 118 high-functioning individuals with autism spectrum disorders (ASD) and in 2016 controls. The ASD group had a higher rate of clinical depression and markedly higher "insomnia" and "restlessness" scores. Network analysis and hierarchical cluster analysis in the ASD group revealed that depression and anxiety items clustered together, but separately from autism-related items. Read More

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http://dx.doi.org/10.1007/s10803-019-03914-4DOI Listing
February 2019

The molecular neurobiology of chronic pain-induced depression.

Cell Tissue Res 2019 Feb 19. Epub 2019 Feb 19.

Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique et Université de Strasbourg, 67000, Strasbourg, France.

The increasing number of individuals with comorbidities poses an urgent need to improve the management of patients with multiple co-existing diseases. Among these comorbidities, chronic pain and mood disorders, two long-lasting disabling conditions that significantly reduce the quality of life, could be cited first. The recent development of animal models accelerated the studies focusing on the underlying mechanisms of the chronic pain and depression/anxiety comorbidity. Read More

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http://dx.doi.org/10.1007/s00441-019-03003-zDOI Listing
February 2019

Changes in Functional Connectivity Following Treatment With Emotion Regulation Therapy.

Front Behav Neurosci 2019 4;13:10. Epub 2019 Feb 4.

Department of Counseling and Clinical Psychology, Teachers College, Columbia University, New York, NY, United States.

Emotion regulation therapy (ERT) is an efficacious treatment for distress disorders (i.e., depression and anxiety), predicated on a conceptual model wherein difficult to treat distress arises from intense emotionality (e. Read More

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http://dx.doi.org/10.3389/fnbeh.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369363PMC
February 2019

[Clinical manifestations of burnout].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):14-16

N. Bekhtereva Institute of the Human Brain Russian Academy of Sciences, St.-Petersburg, Russia.

Aim: To study clinical manifestations of burnout.

Material And Methods: The study included 131 patients (38 men and 93 women) aged from 25 to 45 years. The control group consisted of 106 age-matched healthy people. Read More

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http://dx.doi.org/10.17116/jnevro201911901114DOI Listing
January 2019

Emotion sensitivity across the lifespan: Mapping clinical risk periods to sensitivity to facial emotion intensity.

J Exp Psychol Gen 2019 Feb 18. Epub 2019 Feb 18.

Institute for Technology in Psychiatry, Department of Psychiatry, Division of Depression and Anxiety Disorders, McLean Hospital / Harvard Medical School.

Face emotion perception is important for social functioning and mental health. In addition to recognizing categories of face emotion, accurate emotion perception relies on the ability to detect subtle differences in emotion intensity. The primary aim of this study was to examine participants' ability to discriminate the intensity of facial emotions (emotion sensitivity: ES) in three psychometrically matched ES tasks (fear, anger, or happiness), to identify developmental changes in sensitivity to face emotion intensity across the lifespan. Read More

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http://dx.doi.org/10.1037/xge0000559DOI Listing
February 2019

OnabotulinumtoxinA and cognitive behavioral therapy in functional dystonia: A pilot randomized clinical trial.

Parkinsonism Relat Disord 2019 Feb 13. Epub 2019 Feb 13.

Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

Introduction: Functional dystonia (FD) is a disabling movement disorder with limited therapeutic options. We aimed to examine the efficacy and safety of chemodenervation with OnabotulinumtoxinA (BoNT) versus placebo prior to cognitive behavioral therapy (CBT) in FD patients.

Methods: FD patients with a Psychogenic Movement Disorders Rating Scale (PMDRS) score ≥ 10 and persistent dystonic posturing for ≥ 1 year were randomized to BoNT or placebo injections prior to 12 weekly individualized 1-h CBT sessions. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.009DOI Listing
February 2019

Autonomy deficits as vulnerability for anxiety: evidence from two laboratory-based studies.

Anxiety Stress Coping 2019 Feb 18:1-15. Epub 2019 Feb 18.

a Department of Medical and Clinical Psychology , Tilburg University , Tilburg , Netherlands.

Background: Autonomous individuals are characterized by self-governance; awareness of and capacity to realize one's wishes and needs, while being connected with and sensitive towards others. In line with earlier research showing consistent associations between autonomy-connectedness deficits and anxiety, we tested in two studies whether autonomy deficits predict anxious responses to acute stressors.

Methods: In Study 1, participants (N = 177) viewed an anxiety-inducing film fragment and reported anxiety before and after viewing the clip. Read More

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http://dx.doi.org/10.1080/10615806.2019.1580697DOI Listing
February 2019

[Attention deficit/hyperactivity disorder. Study habits].

Medicina (B Aires) 2019 ;79 Suppl 1:57-61

Servicio de Neurología Infantil, Hospital Universitario Quirónsalud, Madrid, España E-mail:

Attention deficit / hyperactivity disorder (ADHD) is one of the most prevalent disorders in the child-youth population, with a known impact on learning and school performance. Lack of attention, associated executive dysfunction and comorbid problems -particularly those related to learning and anxiety-, strongly determine this conceptual domain. Affected youths have more problems for taking notes, completion of homework, school programming and less motivation to study. Read More

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January 2019

[Reduction of dysfunctional self-injurious and self-stimulatory behaviors in autism disorders spectrum through occupational therapy].

Medicina (B Aires) 2019 ;79 Suppl 1:38-43

RED CENIT, Centros de Desarrollo Cognitivo (CEDECO), Centros de Integración Sensorial (CIS), Valencia, España.

Self-stimulatory and self-injurious behaviors are very frequent in neurodevelopmental disorders, being a source of anxiety and suffering for persons who have that behavior and their families. Sometimes these behaviors are so intense and frequent that it becomes a selfintegrity risk. A bibliographic review was conducted on the different approaches that have been developed until today; in addition, this article explains the methodology applied in our clinic, with a data collection on the effect of therapy on self-injurious and self-stimulatory behaviors in 20 cases, as a starting point for future research. Read More

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January 2019

Development of inhibitory control during childhood and its relations to early temperament and later social anxiety: unique insights provided by latent growth modeling and signal detection theory.

J Child Psychol Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, USA.

Background: Children with the temperament of behavioral inhibition (BI) face increased risk for social anxiety. However, not all children with BI develop anxiety symptoms. Inhibitory control (IC) has been suggested as a moderator of the pathway between BI and social anxiety. Read More

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http://dx.doi.org/10.1111/jcpp.13025DOI Listing
February 2019
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Practitioner Review: Unguided and guided self-help interventions for common mental health disorders in children and adolescents: a systematic review and meta-analysis.

J Child Psychol Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

UCL Great Ormond Street Institute of Child Health, London, UK.

Mental health problems are common in children and adolescents, yet evidence-based treatments are hard to access. Self-help interventions can increase such access. The aim of this paper was to conduct a systematic review and meta-analysis of the use of guided and unguided self-help for children and young people with symptoms of common mental health disorders. Read More

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http://dx.doi.org/10.1111/jcpp.13010DOI Listing
February 2019
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A web-based intervention for carers of individuals with anorexia nervosa (We Can): Trial protocol of a randomised controlled trial investigating the effectiveness of different levels of support.

Internet Interv 2019 Apr 22;16:76-85. Epub 2018 Feb 22.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Section of Eating Disorders, PO Box 59, 16, De Crespigny Park, London, SE5 8AF, UK.

Background: Anorexia nervosa (AN) is a life-threatening mental disorder that is associated with substantial caregiver burden. Carers of individuals with AN report high levels of distress and self-blame, and insufficient knowledge to help their loved ones. However, carers can have a very important role to play in aiding recovery from AN, and are often highly motivated to assist in the treatment process. Read More

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http://dx.doi.org/10.1016/j.invent.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364327PMC

Healthy Teens @ School: Evaluating and disseminating transdiagnostic preventive interventions for eating disorders and obesity for adolescents in school settings.

Internet Interv 2019 Apr 27;16:65-75. Epub 2018 Feb 27.

FernFH Distance Learning University of Applied Sciences, Wiener Neustadt, Austria.

Background: The worldwide prevalence of overweight and obesity is at alarming levels. Nearly one in three children in Europe is overweight or obese. Disordered eating and body image concerns are equally widespread and increase risk for more chronic and severe weight-related problems. Read More

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http://dx.doi.org/10.1016/j.invent.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364512PMC

Efficacy and cost-effectiveness of guided and unguided internet- and mobile-based indicated transdiagnostic prevention of depression and anxiety (ICare Prevent): A three-armed randomized controlled trial in four European countries.

Internet Interv 2019 Apr 15;16:52-64. Epub 2018 Apr 15.

Department of Clinical Psychology and Psychotherapy, Nägelsbachstraße 25a, Germany.

Background: Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Read More

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http://dx.doi.org/10.1016/j.invent.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364519PMC

An Internet based intervention for improving resilience and coping strategies in university students: Study protocol for a randomized controlled trial.

Internet Interv 2019 Apr 22;16:43-51. Epub 2018 Mar 22.

University Jaume, Castellón, Spain.

Background: The literature shows a high prevalence of depression and anxiety in young people. The university represents a change in the lives of students, and is considered a stress factor. Therefore, it is particularly relevant to develop interventions specifically addressed to students and foster supportive environments and resilient communities. Read More

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http://dx.doi.org/10.1016/j.invent.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364440PMC
April 2019
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Web-based indicated prevention of common mental disorders in university students in four European countries - Study protocol for a randomised controlled trial.

Internet Interv 2019 Apr 15;16:35-42. Epub 2018 Mar 15.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Section of Eating Disorders, PO59, 16 De Crespigny Park, London SE5 8AF, United Kingdom.

Background: Mental disorders and their symptoms are highly prevalent in the university student population, and the transition from secondary to tertiary education is associated with a rise in mental health problems. Existing web-based interventions for the prevention of common mental disorders in student populations often focus on just one disorder and have not been designed specifically for students. There is thus a need for transdiagnostic, student-specific preventative interventions that can be widely disseminated. Read More

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http://dx.doi.org/10.1016/j.invent.2018.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364328PMC
April 2019
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Migraine, tension-type headache, and depression among Saudi female students in Taif University.

J Egypt Public Health Assoc 2019 29;94(1). Epub 2019 Jan 29.

1Department of Family and Community Medicine, College of Medicine, Taif University, Alsalama street, Taif city, Saudi Arabia.

Background: Studies done in Saudi Arabia showed a high prevalence of headache among university students. Limited research was done to assess the relationship between headache and psychiatric disorders. The aim of this study was to assess the prevalence and association between migraine, tension-type headache, and depression among Saudi female students in Taif University. Read More

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http://dx.doi.org/10.1186/s42506-019-0008-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351506PMC
January 2019

Demographics and Risk Factors for Non-Accidental Orthopedic Trauma.

Clin Pediatr (Phila) 2019 Feb 16:9922819829045. Epub 2019 Feb 16.

1 Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Childhood non-accidental trauma (NAT) is the second most common cause of death in children. Despite its prevalence, NAT is frequently unreported due to provider misdiagnosis or unawareness. The purpose of this study was to determine current risk factors and injury patterns associated with NAT. Read More

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http://dx.doi.org/10.1177/0009922819829045DOI Listing
February 2019

Early intervention for obsessive compulsive disorder: An expert consensus statement.

Eur Neuropsychopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Sackler Medical School, Tel Aviv University, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.

Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.002DOI Listing
February 2019

Health-related quality of life and psychological wellbeing of children with Specific Learning Disorders and their mothers.

Res Dev Disabil 2019 Feb 14;87:43-53. Epub 2019 Feb 14.

Department of Psychology, University of Bologna, Piazza Aldo Moro, 90, I-47521 Cesena (FC), Italy. Electronic address:

Background: Literature suggests that Specific Learning Disorders (SpLD) can cause impairment of Health-Related Quality of Life (HRQoL) and psychological well-being of children, and that this condition potentially affects parents' quality of life and well-being too.

Aims: This study aims first to explore HRQoL and psychological well-being among children with SpLD and second among mothers of children with SpLD.

Methods And Procedures: Thirty children aged 8-14 years diagnosed as having SpLD and their mothers completed a battery of scales to assess children's HRQoL and psychological well-being. Read More

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http://dx.doi.org/10.1016/j.ridd.2019.02.003DOI Listing
February 2019
2 Reads

Effects of sodium nitroprusside in the acute dizocilpine (MK-801) animal model of schizophrenia.

Brain Res Bull 2019 Feb 14. Epub 2019 Feb 14.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No.388, Jianshe Middle Road, Xinxiang, 453002, Henan, People's Republic of China; Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang, People's Republic of China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, People's Republic of China. Electronic address:

Schizophrenia treatment remains a major challenge, especially the associated cognitive impairments, as these are not consistently alleviated by conventional antipsychotics. Recent animal and clinical studies suggest that the nitric oxide (NO) donor sodium nitroprusside (SNP) reduces the psychiatric symptoms and cognitive deficits of schizophrenia.The present study was designed to investigate the efficacy of SNP against schizophrenia-like behavioral and cognitive deficits in the dizocilpine (MK-801) rat model. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.008DOI Listing
February 2019
2 Reads

Depression is associated with diabetes status of family members: NHANES (1999-2016).

J Affect Disord 2019 Feb 6;249:121-126. Epub 2019 Feb 6.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Background: The majority of the studies in this area focus on the psychological impact of having diabetic children or adolescents on parents, while a limited number of studies have investigated the effect of diabetes on the mental health status of family members in the general population. Thus, the aim of the current study is to explore the possible association between mental health disorders (depression, anxiety and panic) and diabetes status of family members among a national sample of adults in the United States.

Methods: Our analysis included 1,787 and 25,574 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2016, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183302
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http://dx.doi.org/10.1016/j.jad.2019.02.019DOI Listing
February 2019
5 Reads

Kainate receptor auxiliary subunit NETO2 is required for normal fear expression and extinction.

Neuropsychopharmacology 2019 Feb 15. Epub 2019 Feb 15.

Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.

NETO1 and NETO2 are auxiliary subunits of kainate receptors (KARs). They interact with native KAR subunits to modulate multiple aspects of receptor function. Variation in KAR genes has been associated with psychiatric disorders in humans, and in mice, knockouts of the Grik1 gene have increased, while Grik2 and Grik4 knockouts have reduced anxiety-like behavior. Read More

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http://dx.doi.org/10.1038/s41386-019-0344-5DOI Listing
February 2019
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Ultra-high field MRI reveals mood-related circuit disturbances in depression: a comparison between 3-Tesla and 7-Tesla.

Transl Psychiatry 2019 Feb 15;9(1):94. Epub 2019 Feb 15.

The Mood and Anxiety Disorders Program, Department of Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Ultra-high field 7-Tesla (7 T) MRI has the potential to advance our understanding of neuropsychiatric disorders, including major depressive disorder (MDD). To date, few studies have quantified the advantage of resting state functional MRI (fMRI) at 7 T compared to 3-Tesla (3 T). We conducted a series of experiments that demonstrate the improvement in temporal signal-to-noise ratio (TSNR) of a multi-echo multi-band fMRI protocol with ultra-high field 7 T MRI, compared to a similar protocol using 3 T MRI in healthy controls (HC). Read More

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http://dx.doi.org/10.1038/s41398-019-0425-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377652PMC
February 2019
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The Impact of Axial Spondyloarthritis on Mental Health: Results from the Atlas.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From Universidad de Sevilla, Spanish Coordinator of Spondyloarthritis Associations (CEADE), Novartis Spain, Hospital La Paz IdiPAZ. This study was funded by Novartis, Spain. Address Correspondence to: Prof Marco Garrido-Cumbrera, PhD, Health & Territory Research (HTR). Centro de Investigación, Tecnología e Innovación Manuel Losada Villasante. Universidad de Sevilla. C/ Doctor Rafael Martínez Domínguez, s/n. Seville 41013, Spain. E-mail:

Objective: To assess the risk for mental disorders in patients with axSpA and to examine the associated factors with this.

Methods: In 2016, a sample of 680 axSpA patients was interviewed as part of the development process for the Atlas of Axial Spondyloarthritis in Spain. The risk of mental disorders in these patients was assessed using the General Health Questionnaire (GHQ-12) scale. Read More

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http://dx.doi.org/10.3899/jrheum.180868DOI Listing
February 2019
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Open-label trial of anterior limb of internal capsule-nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: insights gained.

J Neurol Neurosurg Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Cologne, Germany.

Background: For more than 15 years, deep brain stimulation (DBS) has served as a last-resort treatment for severe treatment-resistant obsessive-compulsive disorder (OCD).

Methods: From 2010 to 2016, 20 patients with OCD (10 men/10 women) were included in a single-centre trial with a naturalistic open-label design over 1 year to evaluate the effects of DBS in the anterior limb of the internal capsule and nucleus accumbens region (ALIC-NAcc) on OCD symptoms, executive functions, and personality traits.

Results: ALIC-NAcc-DBS significantly decreased OCD symptoms (mean Yale-Brown Obsessive Compulsive Scale reduction 33%, 40% full responders) and improves global functioning without loss of efficacy over 1 year. Read More

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http://dx.doi.org/10.1136/jnnp-2018-318996DOI Listing
February 2019
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Integrated cognitive behavioral therapy for ADHD in adult substance use disorder patients: Results of a randomized clinical trial.

Drug Alcohol Depend 2019 Feb 5;197:28-36. Epub 2019 Feb 5.

Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Background: Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occurs with Substance Use Disorders (SUDs). Standard ADHD pharmacotherapies are not effective in patients with this comorbidity and cognitive behavioral therapy (CBT) has not been tested in this population. This RCT aimed to compare the efficacy of Integrated CBT (CBT/Integrated) directed at adult ADHD and SUD with CBT directed at SUD only (CBT/SUD) in patients with SUD and ADHD (SUD + ADHD). Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.023DOI Listing
February 2019
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Extrinsic and default mode networks in psychiatric conditions: Relationship to excitatory-inhibitory transmitter balance and early trauma.

Neurosci Biobehav Rev 2019 Feb 12;99:90-100. Epub 2019 Feb 12.

Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway.

Over the last three decades there has been an accumulation of Magnetic Resonance Imaging (MRI) studies reporting that aberrant functional networks may underlie cognitive deficits and other symptoms across a range of psychiatric diagnoses. The use of pharmacological MRI and H-Magnetic Resonance Spectroscopy (H-MRS) has allowed researchers to investigate how changes in network dynamics are related to perturbed excitatory and inhibitory neurotransmission in individuals with psychiatric conditions. More recently, changes in functional network dynamics and excitatory/inhibitory (E/I) neurotransmission have been linked to early childhood trauma, a major antecedents for psychiatric illness in adulthood. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.02.004DOI Listing
February 2019
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A Longitudinal Follow-Up Study Examining Adolescent Depressive Symptoms as a Function of Prior Anxiety Treatment.

J Am Acad Child Adolesc Psychiatry 2019 Jan 16. Epub 2019 Jan 16.

Objective: Children who are fearful and anxious are at heightened risk for developing depression in adolescence. Treating anxiety disorders in pre/early adolescence may be one mechanism through which depressive symptoms later in adolescence can be prevented. We hypothesized that anxious youth who responded positively to cognitive behavioral therapy (CBT) for anxiety would show reduced onset of depressive symptoms 2 years later compared to treatment non-responders, and that this effect would be specific to youth treated with CBT compared to an active supportive comparison treatment. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.10.012DOI Listing
January 2019
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Factors involved in sleep efficiency: a population-based study of community-dwelling elderly persons.

Sleep 2019 Feb 15. Epub 2019 Feb 15.

Department of Mathematics, Université du Québec à Montréal, Québec, Canada.

Study Objectives: Research indicates that sleep efficiency below 80% substantially increases mortality risk in elderly persons. The aim of this study was to identify factors that would best predict poor sleep efficiency in the elderly, and to determine whether associations between these factors and sleep efficiency were similar for men and women and for younger and older elderly persons.

Methods: A total of 2,468 individuals aged 65-96 years (40. Read More

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http://dx.doi.org/10.1093/sleep/zsz038DOI Listing
February 2019
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Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease.

J Int Neuropsychol Soc 2019 Feb 15:1-9. Epub 2019 Feb 15.

2Monash Institute of Cognitive and Clinical Neurosciences,School of Psychological Sciences,Monash University,Melbourne,Australia.

Objectives: Previous research has demonstrated an association between emotion recognition and apathy in several neurological conditions involving fronto-striatal pathology, including Parkinson's disease and brain injury. In line with these findings, we aimed to determine whether apathetic participants with early Huntington's disease (HD) were more impaired on an emotion recognition task compared to non-apathetic participants and healthy controls.

Methods: We included 43 participants from the TRACK-HD study who reported apathy on the Problem Behaviours Assessment - short version (PBA-S), 67 participants who reported no apathy, and 107 controls matched for age, sex, and level of education. Read More

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http://dx.doi.org/10.1017/S1355617718001224DOI Listing
February 2019
2 Reads