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BMJ Case Rep 2022 Jun 28;15(6). Epub 2022 Jun 28.

Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

We review the case of an unstable gynaecological patient in the USA who presented with profuse vaginal bleeding after spontaneous miscarriage and was ultimately diagnosed with a uterine arteriovenous malformation managed with interventional radiology embolisation of her uterine artery. Her case was complicated by the presence of an ankle monitoring device which had been placed by US Immigration and Customs Enforcement as part of the Alternatives to Detention programme in which she was enrolled during her immigration proceedings. The device prompted important considerations regarding the potential use of cautery, MRI compatibility and device-related trauma, in addition to causing significant anxiety for the patient, who was concerned about how the team's actions could affect her immigration case. Read More

J Affect Disord 2022 Jun 25. Epub 2022 Jun 25.

Neuroradiology Unit, Neurosciences Department, University of Padova, Azienda Ospedale-Università Padova, Padua, Italy.

Background: COVID-19 is an infectious disease that has spread worldwide in 2020, causing a severe pandemic. In addition to respiratory symptoms, neuropsychiatric manifestations are commonly observed, including chronic fatigue, depression, and anxiety. The neural correlates of neuropsychiatric symptoms in COVID-19 are still largely unknown. Read More

Neuroscience 2022 Jun 25. Epub 2022 Jun 25.

VA Research Service, Charlie Norwood VA Medical Center, Augusta, GA, United States; Department of Pharmacology and Toxicology, Augusta University, Augusta, GA, United States. Electronic address:

Fear memories are important for survival and are implicated in the etiology of fear disorders such as Post Traumatic Stress Disorder (PTSD). Fear memories are well studied pre-clinically and sex differences in rodent fear expression have been reported: females tend to freeze less than males. Whether this is a difference in fear learning or expression is debated. Read More

Neurobiol Aging 2022 Jun 6;117:165-178. Epub 2022 Jun 6.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

Neuropsychiatric symptoms, such as anxiety and depression often appear early in patients with Alzheimer's disease (AD), and a comorbid, anxiety-like phenotype is also found in rodents with AD. However, the underlying mechanisms behind these conditions and potential therapeutic targets to treat them remain unclear. In this study, we used 5 familial AD mutations (5xFAD) mice that developed early amyloid β-amyloid deposition and related synaptic loss and memory deficits to identify a potential mechanism behind abnormally high anxiety levels observed in these subjects. Read More

Health Soc Care Community 2022 Jun 28. Epub 2022 Jun 28.

Department of Applied Pedagogy and Educational Psychology, University of the Balearic Islands, Palma de Mallorca, Spain.

Social intervention with children with disabilities and their families should be understood through the principles of family-centred practice. In Spain, early intervention is understood as interventions aimed at children from 0 to 6 years old and their families. Professionals carry out the reception, assessment and intervention. Read More

Egypt J Neurol Psychiatr Neurosurg 2022 23;58(1):78. Epub 2022 Jun 23.

Psychiatry Department, Faculty of Medicine, Zagazig University, P.O. Box 44519, Zagazig, Egypt.

Background: Epilepsy is one of the most frequent and serious brain disorders. The nature of the disorder and the unpredictability of seizures usually puts patients in a state of apprehension and anticipation, which creates a continuous condition of anxiety. COVID-19 pandemic has created a state of generalized anxiety all over the world. Read More

Nat Sci Sleep 2022 21;14:1175-1186. Epub 2022 Jun 21.

Department of Acupuncture & Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, People's Republic of China.

Background: Gender differences in hippocampal and parahippocampal gyrus (HIP/PHG) volumes have been reported in sleep disorders. Therefore, this study investigated the moderating effect of gender on the relationship between chronic insomnia disorder (CID) and the HIP/PHG functional connectivity (FC) network.

Methods: For this study, 110 patients diagnosed with CID (43 men and 67 women) and 60 matched good sleep control (GSC) (22 men and 38 women) were recruited. Read More

Ann Gen Psychiatry 2022 Jun 27;21(1):23. Epub 2022 Jun 27.

Department of Family Medicine, Semmelweis University, Budapest, Hungary.

Background: Hypertension is a major risk factor of cardiovascular mortality. Mood disorders represent a growing public health problem worldwide. A complex relationship is present between mood disorders and cardiovascular diseases. Read More

BMC Neurol 2022 Jun 27;22(1):235. Epub 2022 Jun 27.

Department of Neurology, West China Hospital, Sichuan University, Guo Xuexiang #37, Chengdu, 610041, China.

Background: Many patients with neurological disorders experience chronic fatigue, but the neural mechanisms involved are unclear.

Objective: Here we investigated whether the brain structural and functional connectivity alterations were involved in fatigue related to neuromyelitis optica spectrum disorder (NMOSD).

Methods: This prospective pilot study used structural and resting-state functional brain magnetic resonance imaging to compare total cortical thickness, cortical surface area, deep gray matter volume and functional connectivity (FC) between 33 patients with NMOSD and 20 healthy controls (HCs). Read More

BMC Psychiatry 2022 Jun 27;22(1):434. Epub 2022 Jun 27.

The Cairnmillar Institute, 391-393 Tooronga Road, Hawthorn East, VIC, 3123, Australia.

Background: The aims of this study were to conduct a cross-cultural validation of the Panic Disorder Severity Scale - Self-Report (PDSS-SR) and to examine psychometric properties of the French-Canadian version.

Methods: A sample of 256 adults were included in the validation study based on data from the baseline interview of a clinical trial on transdiagnostic cognitive-behavioral therapy for mixed anxiety disorders. Participants completed the Anxiety and Related Disorders Interview Schedule (ADIS-5), and self-report instruments including the PDSS-SR, Beck Anxiety Inventory (BAI), Mobility Inventory for Agoraphobia (MIA), Sheehan Disability Scale (SDS), Patient Health Questionnaire (PHQ-9), Social Phobia Inventory (SPIN), Insomnia Severity Index (ISI) and Penn State Worry Questionnaire (PSWQ). Read More

Cogn Affect Behav Neurosci 2022 Jun 27. Epub 2022 Jun 27.

Department of Psychology, University of Essex, Colchester, CO4 3SQ, UK.

Daily life demands that we differentiate between a multitude of emotional facial expressions (EFEs). The mirror neuron system (MNS) is becoming increasingly implicated as a neural network involved with understanding emotional body expressions. However, the specificity of the MNS's involvement in emotion recognition has remained largely unexplored. Read More

J Pediatr Health Care 2022 Jun 24. Epub 2022 Jun 24.

Introduction: We investigated the frequency and variation in three mental health diagnoses among obese or overweight children and adolescents.

Method: Logistic regression was used to examine the association between the outcome variables-anxiety, depression, and adjustment disorders-with the following covariates: overweight/obesity status, sex, age, and race.

Results: Findings show anxiety, depressive, and adjustment disorder diagnoses were significantly higher for overweight or obese youth in our sample. Read More

Biol Psychiatry Cogn Neurosci Neuroimaging 2022 Jun 24. Epub 2022 Jun 24.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address:

Background: Early identification of risk for depression and anxiety disorders is important for prevention, but real-life affective well-being and its biological underpinnings in the population remain understudied. Here, we combined methods from epidemiology, psychology, ecological momentary assessment (EMA) and functional magnetic resonance imaging (fMRI) to study real-life and neural affective functions in individuals with subclinical anxiety and depression from a population-based cohort of young adults.

Methods: We examined psychological measures, real-life affective valence, fMRI amygdala habituation to negative affective stimuli and the relevance of neural readouts for daily-life affective function in 132 non-help-seeking community individuals. Read More

J Affect Disord 2022 Jun 24. Epub 2022 Jun 24.

Amsterdam UMC location Vrije University Amsterdam, Department of Psychiatry, Amsterdam Public Health (Mental Health program) and Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress & Sleep program) research institutes, Amsterdam, the Netherlands. Electronic address:

Background: Childhood trauma (CT) is a risk factor for depressive and anxiety disorders. However, whether CT is more strongly linked to specific clinical features of these disorders remains inconclusive. The current study comprehensively examined cross-sectional and longitudinal associations between CT and depressive/anxiety symptomatology in a large adult sample with current and remitted depressive and/or anxiety disorders. Read More

J Affect Disord 2022 Jun 24. Epub 2022 Jun 24.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Background: Structural brain alterations are observed in major depressive disorder (MDD). However, MDD is a highly heterogeneous disorder and specific clinical or biological characteristics of depression might relate to specific structural brain alterations. Clinical symptom subtypes of depression, as well as immuno-metabolic dysregulation associated with subtypes of depression, have been associated with brain alterations. Read More

Arch Phys Med Rehabil 2022 Jun 24. Epub 2022 Jun 24.

Department of Physical Medicine and Rehabilitation, The University of Texas Health Sciences Center at Houston, Houston, Texas; TIRR Memorial Hermann, Houston, Texas.

Objectives: This systematic review aims to gain a comprehensive understanding of the feasibility, acceptability, and efficacy of mindfulness-based interventions (MBIs) on depression, anxiety, fatigue, and health-related quality of life among individuals with upper motor neuron disorders (UMND).

Data Sources: PubMed, PsycINFO, EMBASE, and CINAHL were searched for relevant studies published between Jan 2001 and June 2021.

Study Selection: Clinical trials published in English evaluating MBIs in adults with the four most common UMND (multiple sclerosis, brain injury including stroke, spinal cord injury, and amyotrophic lateral sclerosis) were included. Read More

Res Dev Disabil 2022 Jun 24;128:104271. Epub 2022 Jun 24.

Sleep Education and Research Laboratory, UCL Institute of Education, London, UK. Electronic address:

Background: There is a growing body of research studying the impact sleep has on attention among typically developing (TD) children, but research is lacking among autistic children.

Aims: The present study aimed to explore, for the first time, differences in (1) attention, (2) sleep parameters among primary school-aged Singaporean autistic children (N = 26) and Singaporean TD children (N = 20), and with UK autistic (N = 11) and UK TD children (N = 16), and (3) the impact of sleep on attention.

Methods And Procedures: Actigraphy was used to objectively assess sleep, and a Continuous Performance Task was used to measure attentional domains. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):48-51

Herzen State Pedagogical University of Russia, St Petersburg, Russia.

The article describes pathogenetic models for insomnia: «3P» model of insomnia, hyperarousal model, and sleep reactivity to stress model. Anxiety and stress are addressed as predisposing, precipitating and perpetuating factors of insomnia. The problem of high comorbidity of insomnia and mental disorders is highlighted. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):35-41

Moscow Institute of Physics and Technology, Moscow, Russia.

Objective: To study the effectiveness and safety of the sleep normalization medical device SONYA in the treatment of insomnia.

Material And Methods: The effectiveness and safety of the SONYA device was studied in 32 subjects randomized into two groups - those who received stimulation using this device and those who received false stimulation (placebo). The indicators of subjective sleep characteristics, polysomnography, and emotional state were evaluated. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):23-28

International Society for the Study of Stress «Stress under control», Moscow, Russia.

The pandemic of coronavirus infection, which has begun in 2019, has not ended to this day. COVID-19 adversely affects human health not only in the acute period of the disease, but also in the long-run: in a large percentage of cases, recovery takes very long, patients require and often have problems returning to their baseline. During the first wave of the pandemic in 2020, researchers noted that about 10-20% of patients didn't fully recover three weeks after the onset of the disease. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2)

In recent years, the problem of sleep disturbance has become particularly acute. The epidemic of coronavirus infection and lockdowns, the flow of contradictory information, as well as the decline in well-being have led to an almost threefold increase in the frequency of sleep disorders against the background of a surge in anxiety and depressive disorders. At the same time, the impact on sleep of foreign policy events and domestic tensions is still awaiting evaluation. Read More

PLoS One 2022 27;17(6):e0269981. Epub 2022 Jun 27.

Macquarie Centre for the Health Economy, Macquarie University, Sydney, New South Wales, Australia.

Background: Increasing both the frequency and quality of social interactions within treatments for anxiety and depressive disorders in older adults may improve their mental health outcomes and quality of life. This study aims to evaluate the clinical efficacy and cost utility of an enhanced cognitive behavioural therapy (CBT) plus social participation program in a sample of older adults with depression and/or anxiety.

Methods: A total of 172 community-dwelling adults aged 65 years or older with an anxiety and/or depressive disorder will be randomly allocated to either an enhanced CBT plus social participation program (n = 86) or standard CBT (n = 86). Read More

Soc Neurosci 2022 Jun 27. Epub 2022 Jun 27.

Social and Cognitive Neuroscience Laboratory, Developmental Disorders Program, Center for Health and Biological Sciences, Mackenzie Presbyterian University, Sao Paulo, Brazil.

Previous studies demonstrated that exposure to humor has beneficial effects on psychological well-being. In the present work, we investigated the behavioral and psychophysiological effects of different types of humor on psychological well-being and on the performance during the execution of a stressful cognitive task. To this aim, we examined the behavioral and psychophysiological effects of ToM humorous and Slapstick humorous comic strips before and after executing a stressful cognitive task. Read More

Nord J Psychiatry 2022 Jun 27:1-14. Epub 2022 Jun 27.

CHRU de Tours, Pôle de Psychiatrie-Addictologie, Tours, France.

Introduction: Psychotherapy has proved its efficacy for treating a wide range of psychological disorders. Most types of psychotherapy have been developed to treat specific disorders and validated through controlled-randomized trials. In recent years, researchers have developed a new way to conceptualize patients' difficulties, focusing on processes instead of diagnoses. Read More

Child Psychiatry Hum Dev 2022 Jun 27. Epub 2022 Jun 27.

Levvel, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.

Selective mutism (SM) is an anxiety disorder in children/adolescents, characterized by the absence of speaking in specific social situations, mostly at school. The selective mutism questionnaire (SMQ) is a parent report, internationally used to assess SM symptomatology and treatment outcomes. Since no assessment instrument for SM was available in the Netherlands, our aim was to investigate the psychometric properties of the Dutch translation of the SMQ, through reliability, confirmatory factor, and ROC analyses conducted on data obtained in 303 children (ages 3-17 years; clinical SM group n = 106, control group n = 197). Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):100-107

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences, St. Petersburg, Russia.

Objective: To study disorders of emotional regulation in different types of attention deficit hyperactivity disorder (ADHD) in children.

Material And Methods: 58 children suffering from ADHD, aged 12 to 15 years were divided into 2 subgroups (38 children with a combined form of ADHD and 20 children with ADHD with a predominance of inattention). The control group consisted of 30 children without manifestations of neuropsychiatric disorders. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):77-84

Research Center of Neurology, Moscow, Russia.

Objective: To identify clinical and laboratory indicators associated with the development of chronic musculoskeletal pain syndrome in young and middle-aged patients with degenerative changes of the spine.

Material And Methods: The study included 103 patients (59 women and 44 men) with a mean age 42 [36; 47] years with chronic musculoskeletal back pain. To verify degenerative changes of the spine, MRI was performed using Magnetom Symphony (Siemens; Germany), Magnetom Verio (Siemens; Germany) devices. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):55-62

Pirogov Russian National Research Medical University, Moscow, Russia.

Objective: Determination of the dose-dependent effect of the Teraligen for various nosological forms of disorders in psychiatric practice and general medicine.

Material And Methods: Analysis of 98 publications included in the database of the RISC (2012-2021) with the identification of disorders (according to ICD-10) in which Teraligen is prescribed or can be used (in adults and children from the age of 7).

Results: Despite a rather long and successful history use, research work on the study drug Teraligen continues. Read More