2,858 results match your criteria Antithrombin Deficiency


Iron-Deficiency and Estrogen Are Associated with Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability.

Circ Res 2020 May 26. Epub 2020 May 26.

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, CHINA.

Epidemiologic studies have identified an associate between iron deficiency (ID) and the use of oral contraceptives (CC) and ischemic stroke (IS). To date, however, the underlying mechanism remains poorly understood. Both ID and CC have been demonstrated to up-regulate the level and iron-binding ability of transferrin, with our recent study showing that this up-regulation can induce hypercoagulability by potentiating FXIIa/thrombin and blocking antithrombin-coagulation proteases interactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.119.316453DOI Listing

Phenotypic and Genotypic Analysis of a Hereditary Antithrombin Deficiency Pedigree Due to a Novel SERPINC1 Mutation (p.Met281Thr).

Hamostaseologie 2020 May 25. Epub 2020 May 25.

Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1145-4224DOI Listing

Antithrombin deficiency as a still underdiagnosed thrombophilia: a primer for internists.

Pol Arch Intern Med 2020 May 19. Epub 2020 May 19.

Antithrombin is a key endogenous anticoagulant that also plays other roles in inflammation, immunity, and other systems. Congenital antithrombin deficiency is the strongest thrombophilia, but with a remarkable clinical heterogeneity. Here, as a primer for internists, we show a practical review of this disorder, focused on molecular basis, diagnostic procedures, prognostic implications and clinical management of patients suffering from this severe, and probably underdiagnosed, thrombophilia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20452/pamw.15371DOI Listing

Cerebral Venous Sinus Thrombosis in Adults with Prothrombotic Conditions: A Systematic Review and a Case from Our Institution.

Cureus 2020 Apr 12;12(4):e7654. Epub 2020 Apr 12.

Internal Medicine, Creighton University Arizona Health Education Alliance/Valleywise Health Medical Center, Phoenix, USA.

Cerebral venous sinus thrombosis (CVST) is a rare condition characterized by elevated intracranial pressure due to impaired cerebral venous drainage, potentially leading to life-threatening consequences. We searched the PubMed electronic database for 'cerebral venous sinus thrombosis' and 'prothrombotic' cases reported in adults (19+ years) and conducted a systematic review for the published literature in the English language pooled with a case from our institution. Data were analyzed regarding patient demographics, risk factors, clinical features, treatment modalities, and outcomes when available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217592PMC

What could be the most advantageous therapeutic approach to avoid both arterial and venous thrombosis in hyperhomocysteinemia?

Curr Cardiol Rev 2020 May 10. Epub 2020 May 10.

Department of Internal Medicine,"L. Vanvitelli" Campania University-Naples. Italy.

Dear Editor, Thrombophilia is the tendency to form blood clots both in arteries and veins [1]. Inherited and acquired high plasma homocysteine (HHcy) levels are judged as thrombophilic agents because can induce both arterial and venous thrombosis [2-5]. But, the association of hHHcy with Venous Thromboembolism (VTE) has been studied less extensively than that with arterial thrombosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1573403X16666200511085701DOI Listing

Clinical and laboratorial description of the differential diagnoses of hemostatic disorders in the horse.

Iran J Vet Res 2020 ;21(1):1-8

Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Córdoba, Spain.

The process of fibrin clot formation is a series of complex and well-regulated reactions involving blood vessels, platelets, procoagulant plasma proteins, natural inhibitors, and fibrinolytic enzymes. Vasculitis can be caused by a variety of different agents as bacteria, viruses, protozoal, rickettsial organisms, toxic, drugs, medications, and neoplasms. The most common cause of vasculitis is the purpura hemorrhagica, which is associated with exposure to ssp. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183377PMC
January 2020

Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis.

Proc Natl Acad Sci U S A 2020 May 4;117(20):10958-10969. Epub 2020 May 4.

Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL 33612;

Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and an orphan disease with no specific treatment. Most patients with confirmed NEC develop moderate-severe thrombocytopenia requiring one or more platelet transfusions. Here we used our neonatal murine model of NEC-related thrombocytopenia to investigate mechanisms of platelet depletion associated with this disease [K. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1912357117DOI Listing

Thrombophilia prevalence in patients seeking laparoscopic sleeve gastrectomy: extended chemoprophylaxis may decrease portal vein thrombosis rate.

Surg Obes Relat Dis 2020 Mar 18. Epub 2020 Mar 18.

Department of Surgery, NYU Langone Medical Center, Bellevue Hospital Center, New York, New York.

Background: Portomesenteric vein thrombosis (PMVT) may occur after laparoscopic sleeve gastrectomy (LSG). Previous studies have shown that PMVT patients may have undiagnosed thrombophilia. We recently changed our practice to check thrombophilia panel in every LSG patient preoperatively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.soard.2020.03.008DOI Listing

Apixaban therapy in a pregnant woman with heparin-induced thrombocytopenia and venous thromboembolic events caused by congenital antithrombin deficiency: A case report.

Case Rep Womens Health 2020 Jul 3;27:e00200. Epub 2020 Apr 3.

Department of Obstetrics and Gynecology, Toho University Omori Medical Center, Japan.

We report the case of a 35-year-old pregnant woman (gravida 3, para 1) with antithrombin deficiency who was successfully treated with apixaban. She had a history of heparin-induced thrombocytopenia and venous thromboembolic events. Pregnancy was confirmed while the patient was having anticoagulant therapy for a persistent thrombus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.crwh.2020.e00200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152699PMC

Chronic Non-cirrhotic Portal Vein Thrombosis with Cavernous Transformation Secondary to Protein C and S Deficiency.

Cureus 2020 Feb 29;12(2):e7142. Epub 2020 Feb 29.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

Hereditary thrombophilia (HT), including the mutation of factor V gene and the deficiency of proteins C, protein S, or antithrombin, is a risk factor for portal vein thrombosis (PVT). PVT in acute cases is usually asymptomatic, whereas chronic cases mostly present as variceal bleeding and splenomegaly. However, cavernous transformation of the portal vein secondary to a long-standing PVT is very rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105261PMC
February 2020

New genetic variant in the SERPINC1 gene: hereditary Antithrombin deficiency case report, familial thrombosis and considerations on genetic counseling.

BMC Med Genet 2020 04 6;21(1):73. Epub 2020 Apr 6.

Medical Genetics Laboratory, Petrovsky National Research Centre of Surgery, Abricosovsky lane, 2, Moscow, 119991, Russian Federation.

Background: Inherited deficiency of the antithrombin (hereditary antithrombin deficiency, AT deficiency, OMIM #613118) is a relatively rare (1:2000-3000) autosomal-dominant disorder with high risk of venous thromboembolism. Mutations in the serpin family C member 1 gene (SERPINC1) can lead to Quantitative (type I) and Qualitative (type II) types of antithrombin deficiency. We describe a new genetic variant in the SERPINC1 gene and our approach to variant interpretation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12881-020-01001-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137186PMC

Prevalence and Outcomes of Thrombophilia in Patients with Acute Pulmonary Embolism.

Vasc Health Risk Manag 2020 9;16:75-85. Epub 2020 Mar 9.

Department of Surgery, Hamad General Hospital (HGH), Doha, Qatar.

Background: We aimed to study the prevalence and outcomes of thrombophilia in acute pulmonary embolism.

Methods: A retrospective observational study was conducted to include patients with a radiologically confirmed diagnosis of PE screened for thrombophilia from May 2011 to February 2015. Data included patients' demographics; clinical presentation, risk factors, laboratory investigations, management, and outcome were analyzed and compared in patients with and without thrombophilia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/VHRM.S241649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082538PMC

ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.

J Cardiol Cases 2020 Mar 22;21(3):106-109. Epub 2019 Nov 22.

Department No 2, Medical Faculty of the N.I. Pirogov National Research Medical University, Moscow, Russia.

This clinical case report describes the simultaneous development of an acute myocardial infarction, stroke, and a massive pulmonary thromboembolism in a 44-year-old patient - a carrier of the thrombophilia gene polymorphisms: MTHFR C677T, А1298C, PAI-1 4G/5G, ITGA2 C807T. Multifocal thrombosis was probably due to the initial congenital deficiency of anticoagulants, accompanied by a decrease in antithrombin III and protein C, against the background of their critical consumption in cascade thrombosis, in combination with the carrier of polymorphisms of moderate and low thrombogenic risk. This case is unique in that there is usually a tendency toward clinical thrombosis when the level of antithrombin III is less than 70%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jccase.2019.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054660PMC

Seventeen novel SERPINC1 variants causing hereditary antithrombin deficiency in a Czech population.

Thromb Res 2020 May 2;189:39-41. Epub 2020 Mar 2.

NRL for Disorders in Hemostasis, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2020.02.025DOI Listing

Plasma Protein Signatures of a Murine Venous Thrombosis Model and Slc44a2 Knockout Mice Using Quantitative-Targeted Proteomics.

Thromb Haemost 2020 Mar 5;120(3):423-436. Epub 2020 Mar 5.

UVic-Genome British Columbia Proteomics Centre, Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

The plasma compartment of the blood holds important information on the risk to develop cardiovascular diseases such as venous thrombosis (VT). Mass spectrometry-based targeted proteomics with internal standards quantifies proteins in multiplex allowing generation of signatures associated with a disease or a condition. Here, to demonstrate the method, we investigate the plasma protein signatures in mice following the onset of VT, which was induced by RNA interference targeting the natural anticoagulants antithrombin and protein C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0040-1702229DOI Listing

Successful treatment with rivaroxaban of an extended deep vein thrombosis complicated by pulmonary embolism in a patient with familial antithrombin III deficiency: a case report.

Eur Heart J Case Rep 2020 Feb 23;4(1):1-5. Epub 2019 Dec 23.

Arrhythmology Unit, Heart Department, "SS. Annunziata" Hospital, Via Dei Vestini, 66100 Chieti, Italy.

Background : Patients with low levels of antithrombin III (AT III) are at an increased risk of developing arteriovenous thromboembolic disease.

Case Summary : We report a case of a 28-year-old woman who presented with a 1-week history of spontaneous right calf pain and swelling. A heterozygous AT III deficiency, phenotypically expressed as deep vein thrombosis, was reported in the patient's mother and sister. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcr/ytz235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047071PMC
February 2020

Risk of pregnancy-related venous thromboembolism and obstetrical complications in women with inherited type I antithrombin deficiency: a retrospective, single-centre, cohort study.

Lancet Haematol 2020 Apr 26;7(4):e320-e328. Epub 2020 Feb 26.

Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda-Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy. Electronic address:

Background: Inherited quantitative (type I) deficiency of plasma antithrombin is associated with a high risk of venous thromboembolism, which further increases in pregnancy. Inherited thrombophilia also increases the risk of obstetrical complications, but data on maternal and fetal outcomes in women with antithrombin deficiency are scarce. The aim of this study was to evaluate the risk of pregnancy-associated venous thromboembolism and obstetrical complications in women with type I antithrombin deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(20)30007-7DOI Listing

Antithrombin deficiency in pregnancy-the unresolved issues.

Authors:
Mirjana Kovac

Lancet Haematol 2020 04 26;7(4):e276-e278. Epub 2020 Feb 26.

Faculty of Medicine, University of Belgrade, Belgrade Serbia; and Blood Transfusion Institute of Serbia, Hemostasis Department, 11000 Belgrade, Serbia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(20)30038-7DOI Listing

Identification and characterization of a novel variant in C-terminal region of Antithrombin (Ala427Thr) associated with type II AT deficiency leading to polymer formation.

J Thromb Thrombolysis 2020 Feb 4. Epub 2020 Feb 4.

Protein Conformation and Enzymology Lab, Department of Biosciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.

Antithrombin (AT) deficiency is a rare but strong risk factor for the thrombosis development. Mutations in gene encoding AT (SERPINC1) have provided a detailed understanding of AT deficiency and subsequent development of thrombotic complications. In the present study, we describe a case of thrombotic patient with reduced AT activity and normal AT antigen levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-020-02048-0DOI Listing
February 2020

A novel mutation of SERPINC1 in a patient presenting as recurrent cerebral sinus venous and portal vein thrombosis.

Blood Coagul Fibrinolysis 2020 Apr;31(3):229-232

Department of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University, School of Medicine.

: Inherited antithrombin deficiency (OMIM 107300) is a rare autosomal dominant disorder that could increase the risk of venous thromboembolism and is usually caused by mutations of SERPINC1. Herein, we present a case of a novel mutation in the SERPINC1 gene in a Chinese patient. The patient was a 54-year-old man who presented with recurrent venous thromboembolism and was without a recent history of any precipitating factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MBC.0000000000000893DOI Listing

Supplementation with antithrombin III ex vivo optimizes enoxaparin responses in critically injured patients.

Thromb Res 2020 Mar 15;187:131-138. Epub 2020 Jan 15.

The Center for Translational Injury Research, Department of Surgery, UTHealth McGovern Medical School, Houston, TX, United States of America; Red Duke Trauma Institute, Memorial Hermann Hospital, Houston, TX, United States of America.

Background: The high incidence of venous thromboembolism (VTE) following trauma persists in spite of aggressive thromboprophylaxis strategies. Approximately half of VTE patients do not achieve the recommended anti-FXa response to enoxaparin anticoagulation (0.1-0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2020.01.014DOI Listing

Aggressive progression of Takayasu's arteritis in infancy: a case report.

Acta Clin Croat 2019 Sep;58(3):535-539

1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Department of Traumatology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3Department of Surgery, Dubrava University Hospital, Zagreb, Croatia; 4Department of Pediatric Surgery, Osijek University Hospital Centre, Osijek, Croatia; 5Department of Pathology and Forensic Medicine, Osijek University Hospital Centre, Osijek, Croatia; 6Department of Pediatrics, Osijek University Hospital Centre, Osijek, Croatia.

Takayasu's arteritis (TA) affects the aorta and its branches. Immunosuppressants are the usual course of therapy, while surgery has been used in acute cases. There is only scant information on TA in infancy, and the nonspecific symptoms in the initial stage of the disease make the diagnosis difficult and delayed, thus increasing the mortality rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20471/acc.2019.58.03.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971795PMC
September 2019
0.421 Impact Factor

Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor.

Blood Adv 2020 Jan;4(1):207-216

UNC Blood Research Center, Division of Hematology and Oncology, Department of Medicine, and.

The intrinsic tenase complex (FIXa-FVIIIa) of the intrinsic coagulation pathway and, to a lesser extent, thrombin-mediated activation of FXI, are necessary to amplify tissue factor (TF)-FVIIa-initiated thrombin generation. In this study, we determined the contribution of murine FIX and FXI to TF-dependent thrombin generation in vitro. We further investigated TF-dependent FIX activation in mice and the contribution of this pathway to hemostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/bloodadvances.2019000921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960463PMC
January 2020

Managing thromboembolic risk in patients with hereditary and acquired thrombophilias.

Blood 2020 Jan;135(5):344-350

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

While we are now able to diagnose inherited thrombophilias in a substantial number of patients with venous thromboembolism (VTE), the initial hope that their presence would inform recurrence risk and thus decisions on anticoagulation duration has largely been disappointing. Indeed, the presence or absence of transient provoking risk factors has proven to be the most important determinant of VTE recurrence risk. Thus, particular attention to transient acquired risk factors for VTE remains paramount, as they have generally been shown to carry more prognostic weight than inherited thrombophilias. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019000917DOI Listing
January 2020

Recommendations for clinical laboratory testing for antithrombin deficiency; Communication from the SSC of the ISTH.

J Thromb Haemost 2020 Jan;18(1):17-22

Department of Pathology, Special Coagulation Laboratory, TriCore Reference Laboratories, University of New Mexico, Albuquerque, NM, USA.

Hereditary deficiency of antithrombin, a natural anticoagulant, causes a thrombophilia with a high risk for venous thromboembolism. Guidance for laboratory testing to diagnose antithrombin deficiency include the use of an activity assay for initial testing, performing an antigen test and activity-to-antigen ratio when the activity level is low, using pediatric reference ranges until the age of 6 months, excluding acquired causes of low antithrombin (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jth.14648DOI Listing
January 2020

Congenital antithrombin deficiency in patients with splanchnic vein thrombosis.

Liver Int 2020 May 16;40(5):1168-1177. Epub 2020 Jan 16.

Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS and CIBERehd, Barcelona, Spain.

Background And Aims: Splanchnic vein thromboses (SVT) are a rare condition that can be life-threatening. The most severe thrombophilia associated to SVT is antithrombin (AT) deficiency, usually caused by SERPINC1 mutations. Although transitory AT deficiencies and congenital disorders of the N-glycosylation pathways (CDG) have been recently reported as causes of AT deficiency, the current AT clinical screening still only includes anti-FXa activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/liv.14342DOI Listing

A Molecular Revolution in the Treatment of Hemophilia.

Mol Ther 2020 Apr 13;28(4):997-1015. Epub 2019 Nov 13.

Department of Pediatrics, Indiana University School of Medicine, IUPUI-Wells Center for Pediatric Research, Indianapolis, IN, USA; Laboratory of Glycobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland. Electronic address:

For decades, the monogenetic bleeding disorders hemophilia A and B (coagulation factor VIII and IX deficiency) have been treated with systemic protein replacement therapy. Now, diverse molecular medicines, ranging from antibody to gene to RNA therapy, are transforming treatment. Traditional replacement therapy requires twice to thrice weekly intravenous infusions of factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2019.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132613PMC

Unexpected abnormal coagulation test results in a 2-year-old child: A case report.

Biochem Med (Zagreb) 2020 Feb 15;30(1):011002. Epub 2019 Dec 15.

Department of transfusion medicine, General Hospital Pula, Pula, Croatia.

Rejection of the sample with repeated blood withdrawal is always an unwanted consequence of sample nonconformity and preanalytical errors, especially in the most vulnerable population - children. Here is presented a case with unexpected abnormal coagulation test results in a 2-year-old child with no previously documented coagulation disorder. Child is planned for tympanostomy tubes removal under the anaesthesia driven procedure, and preoperative coagulation tests revealed prolonged prothrombin time, activated partial thromboplastin time and thrombin time, with fibrinogen and antithrombin within reference intervals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11613/BM.2020.011002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904964PMC
February 2020

[Clinical characteristics of patients with chronic thromboembolic pulmonary hypertension].

Zhonghua Yi Xue Za Zhi 2019 Nov;99(44):3461-3465

Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the clinical characteristics of patients with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH cases consecutively admitted into China-Japan Friendship Hospital from September 2015 to June 2019 were enrolled with prospective data collection. The medical histories, clinical characteristics, laboratory tests, imaging manifestation and hemodynamic parameters were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.44.003DOI Listing
November 2019

Superior mesenteric venous thrombosis as a first manifestation of Antithrombin III deficiency in the postoperative course of laparoscopic sleeve gastrectomy: a case study of 2 patients from 1211 bariatric patients.

J Surg Case Rep 2019 Nov 20;2019(11):rjz306. Epub 2019 Nov 20.

Department of Surgery, 5th Surgical Clinic, Evgenidion Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Superior mesenteric venous thrombosis (SMVT) following laparoscopic sleeve gastrectomy (LSG) is a rare, potentially life-threatening complication, which presents either isolated, or as a part of portal/mesenteric/splenic vein thrombosis. Distinction between them possibly confers an important clinical and prognostic value. Antithrombin III (ATIII) deficiency causes an hypercoagulable state which predisposes to SMVT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jscr/rjz306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865349PMC
November 2019

Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX.

Arterioscler Thromb Vasc Biol 2020 01 26;40(1):103-111. Epub 2019 Nov 26.

Laboratory for Clinical Thrombosis and Haemostasis, Departments of Biochemistry and Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands (M.V., R.v.O., H.t.C., H.M.H.S.).

Objectives: FXIa (factor XIa) induces clot formation, and human congenital FXI deficiency protects against venous thromboembolism and stroke. In contrast, the role of FXI in hemostasis is rather small, especially compared with FIX deficiency. Little is known about the cause of the difference in phenotypes associated with FIX deficiency and FXI deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.119.313503DOI Listing
January 2020
5 Reads

Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency.

Taiwan J Obstet Gynecol 2019 Nov;58(6):849-851

Department of Obstetrics & Gynecology, Sapporo Medical University, South 1 West 16, Sapporo, Hokkaido, Japan.

Objective: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency.

Case Report: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tjog.2019.09.021DOI Listing
November 2019

Exogenous supplementation of antithrombin III in adult and pediatric patients receiving extracorporeal membrane oxygenation.

Int J Artif Organs 2020 May 21;43(5):315-322. Epub 2019 Nov 21.

Department of Pharmacy, Lifespan-Rhode Island Hospital & Hasbro Children's Hospital, Providence, RI, USA.

Background: Antithrombin III deficiency can occur with heparin anticoagulation during extracorporeal membrane oxygenation leading to heparin resistance. Antithrombin III supplementation has been shown to improve anticoagulation; however, there is no consensus on appropriate administration. We described the effect of antithrombin III supplementation on coagulation parameters in adult and pediatric extracorporeal membrane oxygenation patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0391398819888932DOI Listing

Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation.

World J Crit Care Med 2019 Oct 16;8(6):87-98. Epub 2019 Oct 16.

Department of Anesthesia, Mayo Clinic, Rochester, MN 55905, United States.

Use of extracorporeal membrane oxygenation to support patients with critical cardiorespiratory illness is increasing. Systemic anticoagulation is an essential element in the care of extracorporeal membrane oxygenation patients. While unfractionated heparin is the most commonly used agent, unfractionated heparin is associated with several unique complications that can be catastrophic in critically ill patients, including heparin-induced thrombocytopenia and acquired antithrombin deficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5492/wjccm.v8.i6.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854393PMC
October 2019

Congenital disorders of glycosylation as an unusual cause of antithrombin deficiency and elevated thrombin generation.

Pediatr Blood Cancer 2020 02 17;67(2):e28069. Epub 2019 Nov 17.

Division of Hematology/Oncology, Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.28069DOI Listing
February 2020

Cavernous Transformation of Portal Vein in the Setting of Protein C and Anti-thrombin III Deficiency.

Cureus 2019 Sep 27;11(9):e5779. Epub 2019 Sep 27.

Pediatrics, Dow University of Health Sciences, Karachi, PAK.

Cavernous transformation of the portal vein (CTPV), also known as portal cavernoma, is a sequelae of thrombosis in the portal vein causing its occlusion and portal hypertension. The etiology, however, remains unknown. Gastroesophageal variceal bleeding, splenomegaly, portosystemic collaterals, and ultimate hematologic abnormalities are among the prominent clinical features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.5779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825486PMC
September 2019

Prevalence of prothrombotic factors in patients with Budd-Chiari syndrome or non-cirrhotic nonmalignant portal vein thrombosis: A hospital-based observational study.

J Gastroenterol Hepatol 2019 Nov 11. Epub 2019 Nov 11.

Department of Liver Disease and Digestive Interventional Radiology, National Clinical Research Center for Digestive Disease and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Background And Aim: Comprehensive investigations on the prothrombotic factors of splanchnic vein thrombosis (SVT), including Budd-Chiari syndrome (BCS) and non-cirrhotic nonmalignant portal vein thrombosis (PVT), in Eastern patients are scarce.

Methods: Between March 2012 and July 2017, 812 consecutive patients, including 418 BCS and 394 non-cirrhotic nonmalignant PVT patients, were admitted to Xijing Hospital (a Chinese tertiary academic hospital) and screened for prothrombotic factors. Odds ratios (ORs), 95% confidence intervals (CIs), and P-trends were calculated by using conditional logistic regression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14925DOI Listing
November 2019

Screening for paroxysmal nocturnal hemoglobinuria (PNH) in patients presenting with cerebral sinovenous thrombosis (CSVT): Results of a FLAER based flowcytometry study in Indian patients.

J Thromb Thrombolysis 2020 May;49(4):584-590

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Patients with paroxysmal nocturnal hemoglobinuria (PNH) may present with thrombosis at unusual sites, of which cerebral sinovenous thrombosis (CSVT) is one and screening for PNH is recommended in this condition. Though many patients diagnosed with PNH develop CSVT, it is unclear how many patients with PNH would present for the first time with thrombosis. We analysed the results of screening for PNH by flowcytometry in our patients with CSVT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11239-019-01982-yDOI Listing
May 2020
2.039 Impact Factor

How I treat patients with hereditary antithrombin deficiency.

Blood 2019 12;134(26):2346-2353

Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Genetic predispositions to venous thromboembolism (VTE) are relatively frequent in the general population and comprise a heterogeneous group of disorders. Whereas the most frequent congenital risk factors for thrombosis only moderately increase the risk, a deficiency in antithrombin (AT), one of the most important natural inhibitors of blood coagulation, carries a higher risk. Congenital AT deficiency is an infrequently encountered genetic risk factor for VTE, and different subtypes vary with regard to their thrombotic risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019002927DOI Listing
December 2019

Use of Antithrombin Concentrate for Acquired Antithrombin Deficiency in Acutely Unwell Children Receiving Unfractionated Heparin.

Semin Thromb Hemost 2019 11 21;45(8):859-864. Epub 2019 Oct 21.

Department of Haematology, Imperial College Healthcare NHS Trust, Imperial College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1700521DOI Listing
November 2019

Henoch-Schönlein Purpura Nephritis and Cerebral Venous Sinus Thrombosis Due to Hereditary Deficiency of Antithrombin III.

Indian J Pediatr 2020 02 17;87(2):163-164. Epub 2019 Oct 17.

Department of Pediatrics, Jinling Hospital, Southern Medical University, Nanjing, China.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12098-019-03081-5
Publisher Site
http://dx.doi.org/10.1007/s12098-019-03081-5DOI Listing
February 2020
2 Reads

Thromboprophylaxis with antithrombin gamma and unfractionated heparin for a pregnant woman complicated by hereditary antithrombin deficiency.

Int J Gynaecol Obstet 2020 02 27;148(2):263-264. Epub 2019 Oct 27.

Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijgo.12996DOI Listing
February 2020
1 Read

Association of Gene Polymorphism (rs2227589) With Pulmonary Embolism Risk in a Chinese Population.

Front Genet 2019 13;10:844. Epub 2019 Sep 13.

Key Laboratory of Shenzhen Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Disease, The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

Genetic variants in the gene have been shown to be associated with antithrombin deficiency, which subsequently contributes to the susceptibility to venous thrombosis. However, several other studies have shown conflicting results regarding the association of gene polymorphisms (rs2227589) with the risk of thrombosis. Hence, in the present study, we conducted a case-control study to further evaluate the association between the variant rs2227589 with antithrombin deficiency in pulmonary embolism (PTE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2019.00844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753222PMC
September 2019
1 Read

Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy.

Intern Med 2020 Jan 26;59(2):235-239. Epub 2019 Sep 26.

Department of Cardiology, Fukuoka University School of Medicine, Japan.

A 37-year-old woman developed deep venous thrombosis (DVT) of the left lower extremity at 8 weeks of gestation during her second pregnancy. There was no personal or family history of thrombosis. She received intravenous heparin, but heparin resistance was noted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.3268-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008054PMC
January 2020
2 Reads

MRI Diagnosis of Obesity-Related Spinal Epidural Lipomatosis.

Can J Neurol Sci 2019 Sep 24:1-2. Epub 2019 Sep 24.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

A 61-year-old male presented to our hospital complaining of claudication: bilateral leg weakness impeding mobility. Symptoms started after 100 m of walk and recede after several minutes of rest. The patient was obese, with a body mass index (BMI) of 41 kg/m2 and reported a weight gain of about 55 pounds in the last year. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/cjn.2019.301DOI Listing
September 2019
1 Read
1.599 Impact Factor

Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis.

J Am Heart Assoc 2019 10 24;8(19):e012877. Epub 2019 Sep 24.

Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA.

Background Inherited thrombophilias are well-established predisposing factors for venous thromboembolism, but their role in arterial thrombosis, such as arterial ischemic stroke, remains uncertain. We aimed to evaluate the association between inherited thrombophilia (factor V Leiden, prothrombin G20210A mutation, protein C deficiency, protein S deficiency, and antithrombin deficiency) and risk of arterial ischemic stroke in adults. Methods and Results We searched PubMed, EMBASE, and Cochrane Library Databases from inception to December 31, 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.119.012877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806047PMC
October 2019
6 Reads
2.882 Impact Factor

Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up.

PLoS One 2019 20;14(9):e0222102. Epub 2019 Sep 20.

Department of Nephrology and Rheumatology, Georg-August University, Goettingen, Germany.

Objective: Thrombophilic risk factors (TRFs) occur rather frequently in hemodialysis (HD) patients. However, little is known about their significance in HD patients, besides their potential impact on arteriovenous (AV) access failure, with varying results. We examined the effects of a wide variety of TRFs on both early AV fistula occlusion and survival among HD patients in long-term follow-up. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222102PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754127PMC
March 2020
3 Reads

Two Novel Mutations Cause Hereditary Antithrombin Deficiency in a Chinese Family.

Acta Haematol 2019 Sep 3:1-6. Epub 2019 Sep 3.

Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China,

Objective: To study the molecular basis of hereditary antithrombin (AT) deficiency in a Chinese family. It will help us understand the pathogenesis of this type of disease.

Method: AT activity (AT:A) and the AT antigen (AT:Ag) level were tested by chromogenic substrate and immunoturbidimetry, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000502109DOI Listing
September 2019
4 Reads

Plasma kallikrein contributes to ambient particulate matter-induced lung injury.

Biochem Biophys Res Commun 2019 10 23;518(3):409-415. Epub 2019 Aug 23.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China; The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, 19140, USA. Electronic address:

Particulate matter (PM) is a key component of air pollutants and is associated with mortality of cardiovascular and respiratory diseases. PM-induced tissue injury involves inflammation and coagulation. Plasma prekallikrein (pKal), along with coagulation factor XII (FXII) and high-molecular-weight kininogen (HK), form the plasma kallikrein-kinin system (KKS), a component of the innate immune response that generates proinflammatory products in response to injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.07.060DOI Listing
October 2019
3 Reads

A case report of extramedullary haematopoiesis within left ventricle myocardium and apical thrombus in acute heart failure: diagnosis, treatment, and long-term outcome.

Eur Heart J Case Rep 2019 Jun;3(2)

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, USA.

Background : Extramedullary haematopoiesis (EMH) within myocardium is a rare phenomenon, and its occurrence in left ventricle myocardium or apical thrombus of a young female has never been reported.

Case Summary : A 23-year-old active female with progressive worsening of dyspnoea. A transthoracic echocardiogram demonstrated a left ventricular ejection fraction of 10-15% and apical thrombus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcr/ytz065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601185PMC
June 2019
6 Reads