10,614 results match your criteria Antiphospholipid Syndrome


An Unusual Case of Antiphospholipid Syndrome Presenting as Chorea.

Cureus 2018 Oct 29;10(10):e3508. Epub 2018 Oct 29.

Neurology, University of Missouri, Columbia, USA.

Movement disorders are rarely reported in association with antiphospholipid syndrome (APS). Although it is a rare manifestation in APS, chorea is the most common movement disorder. We report a case of APS in a patient who presented with hyperkinesia, tics, choreiform movements, and other dyskinetic movements involving the mouth and tongue along with behavioral changes. Read More

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http://dx.doi.org/10.7759/cureus.3508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318103PMC
October 2018

Near-complete recanalization of jugular vein and multiple dural sinus thromboses with warfarin in a case of antiphospholipid syndrome.

Reumatologia 2018 23;56(6):406-408. Epub 2018 Dec 23.

Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey.

Antiphospholipid syndrome is a cause of arterial and venous thrombosis especially in the young adult population. Although dural sinus thrombosis is a relatively rare complication of antiphospholipid syndrome, it may be a cause of morbidity and mortality. Extension of thrombosis and involvement of deep venous structures are poor prognostic factors in patients with dural sinus thrombosis, but the rate of near-complete recanalization is not known in antiphospholipid syndrome-related dural sinus thrombosis. Read More

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http://dx.doi.org/10.5114/reum.2018.80720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330675PMC
December 2018

Thromboinflammation: Challenges of Therapeutically Targeting Coagulation and other Host Defence Mechanisms.

Blood 2019 Jan 14. Epub 2019 Jan 14.

Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a broad range of human disorders. It is well recognized clinically in the context of superficial thrombophlebitis (thrombosis and inflammation of superficial veins), however it is more dangerous when it develops in the microvasculature of injured tissues and organs. Microvascular thrombosis with associated inflammation is well recognized in the context of sepsis and ischemia-reperfusion injury, however it also occurs in organ transplant rejection, major trauma, severe burns, the antiphospholipid syndrome, preeclampsia, sickle cell disease and biomaterial-induced thromboinflammation. Read More

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http://dx.doi.org/10.1182/blood-2018-11-882993DOI Listing
January 2019

Autoimmune myelofibrosis: a rare haematological involvement in systemic lupus erythematosus.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Internal Medicine and Infectious Disease Department, Centre Hospitalier Sud Ile de France, Melun, France.

Autoimmune myelofibrosis is a distinct clinicopathological entity that occurs with autoimmune disorders. We report the case of a 44-year-old woman admitted with pancytopenia and clinical features of systemic lupus erythematosus, Sjogren's syndrome and antiphospholipid antibodies syndrome. Bone marrow biopsy showed decreased global cells and an increase of reticulin fibres on argentic coloration, consistent with myelofibrosis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22752
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http://dx.doi.org/10.1136/bcr-2018-227520DOI Listing
January 2019
1 Read

BISPHOSPHONATE-INDUCED BILATERAL ANTERIOR UVEITIS AND CHOROIDAL EFFUSIONS WITH SECONDARY ANGLE CLOSURE.

Retin Cases Brief Rep 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology, National Healthgroup Eye Institute, Tan Tock Seng Hospital, Singapore.

Purpose: To report a case of bisphosphonate-induced bilateral anterior uveitis and choroidal effusions with secondary angle closure in a 64-year-old female patient.

Methods: Observational case report.

Results: A 64-year-old woman with history of scleroderma and antiphospholipid syndrome, presented with bilateral painless blurring of vision after commencement of alendronate. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000850DOI Listing
January 2019

Recurrent venous thromboembolism after discontinuation of rivaroxaban therapy in a patient with antiphospholipid syndrome.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Cardiovascular Medicine, Tokushima University Graduate School of BiomedicalSciences, Tokushima, Japan.

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by thromboembolic events including venous thromboembolism (VTE) in association with the presence of antiphospholipid antibodies. The standard treatment of VTE historically consists of anticoagulation therapy with warfarin, a vitamin K antagonist. Recently, direct oral anticoagulants, including rivaroxaban have become available for the treatment of VTE. Read More

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http://dx.doi.org/10.1136/bcr-2018-227663DOI Listing
January 2019
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Catastrophic antiphospholipid syndrome causing ST-segment elevation myocardial infarction with non-obstructive coronary arteries.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Cardiology, West Suffolk NHS Foundation Trust, Bury Saint Edmunds, UK.

A 51-year-old woman with known primary antiphospholipid syndrome presented with a 4-day history of chest and abdominal pain, inferior ST-segment elevation on a 12-lead ECG and a subtherapeutic international normalised ratio. In view of a significantly raised high-sensitivity troponin I assay, inferior wall hypokinesis on transthoracic echocardiography and despite unobstructed epicardial vessels on emergency coronary angiography, a diagnosis of myocardial infarction was made. Furthermore, the patient also developed both bilateral adrenal haemorrhages leading to acute adrenal insufficiency and microvascular thrombotic renal disease concurrently. Read More

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http://dx.doi.org/10.1136/bcr-2018-225495DOI Listing
January 2019

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018

Mechanisms of Endothelial Dysfunction in Antiphospholipid Syndrome: Association With Clinical Manifestations.

Front Physiol 2018 21;9:1840. Epub 2018 Dec 21.

Grupo Reproducción, Departamento de Microbiología y Parasitología, Escuela de Medicina, Universidad de Antioquia, Medellín, Colombia.

The endothelium is a monolayer of cells that covers the inner surface of blood vessels and its integrity is essential for the maintenance of vascular health. Endothelial dysfunction is a key pathological component of antiphospholipid syndrome (APS). Its systemic complications include thrombotic endocarditis, valvular dysfunction, cerebrovascular occlusions, proliferative nephritis, deep vein thrombosis, and pulmonary embolism. Read More

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http://dx.doi.org/10.3389/fphys.2018.01840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309735PMC
December 2018

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
1 Read

Connective Tissue Disorders in Childhood: Are They All the Same?

Radiographics 2019 Jan-Feb;39(1):229-250

From the Departments of Radiology (M.N., E.J.I.C., M.R.P.) and Rheumatology (E.I., J.A.), Hospital Sant Joan de Déu, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada (M.N., O.M.N.); and Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada (M.N., O.M.N.).

Systemic connective tissue disorders are characterized by the presence of autoantibodies and multiorgan system involvement. Juvenile systemic lupus erythematosus with or without associated antiphospholipid syndrome; juvenile dermatomyositis; sclerodermiform syndromes, including systemic and localized sclerodermas and eosinophilic fasciitis; mixed connective tissue disease; and Sjögren syndrome are the disorders that affect children most frequently. Diagnosis is difficult, because the clinical presentation of patients is diverse, from mild to severe disease. Read More

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http://dx.doi.org/10.1148/rg.2019180078DOI Listing
January 2019
1 Read

Prevalence and Significance of Non-conventional Antiphospholipid Antibodies in Patients With Clinical APS Criteria.

Front Immunol 2018 14;9:2971. Epub 2018 Dec 14.

Laboratory of Immunology, HEGP, APHP, Paris, France.

The biological diagnostics of antiphospholipid syndrome (APS) takes into account the persistent positivity for anticardiolipin and/or anti-β2GP1 antibodies and/or presence of lupus anticoagulant (LA). However, some non-conventional antiphospholipid antibodies have emerged that could help in the diagnosis of APS. To study the potential usefulness of non-conventional antiphospholipid antibodies in clinical practice. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302212PMC
December 2018

Elevated plasma level of soluble triggering receptor expressed on myeloid cells-1 is associated with inflammation activity and is a potential biomarker of thrombosis in primary antiphospholipid syndrome.

Arthritis Res Ther 2019 Jan 7;21(1):10. Epub 2019 Jan 7.

Rheumatology Unit, Rabin Medical Center - Beilinson Hospital, 4941492, Petach Tikva, Israel.

Background: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an innate-immune receptor found in blood. Its presence reflects innate immune cell activation. We sought to investigate plasma sTREM-1 levels in patients with primary antiphospholipid syndrome (PAPS). Read More

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http://dx.doi.org/10.1186/s13075-018-1779-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323669PMC
January 2019

Management of pregnant women with antiphospholipid antibodies.

Expert Rev Clin Immunol 2019 Jan 8. Epub 2019 Jan 8.

a Rheumatology Unit, Department of Medicine , University Hospital of Padua , Via Giustiniani, 2, 35128 Padua , Italy.

Introduction: Important advancements in pregnancy outcome have been reported in women with antiphospholipid antibodies (aPL), despite the fact that the treatment of aPL related pregnancy morbidity is not guided by consistent findings from well-designed trials. Areas covered: The current study draws a picture of the studies in the literature by performing a Medline search of relevant English language articles and reports our experience in managing different subsets of obstetric antiphospholipid syndrome (APS), defined on the basis of their clinical and laboratory characteristics. The management of pregnant women with non-criteria APS manifestations and that of aPL carriers during their first pregnancy is also examined. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1565995DOI Listing
January 2019

Valvular heart disease in Antiphospholipid antibody syndrome: Isolated Tricuspid stenosis.

Echocardiography 2019 Jan 6. Epub 2019 Jan 6.

Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India.

Antiphospholipid antibody syndrome (APLS) is a rare disorder characterized by a hypercoagulable state. Manifestations include arterial or venous thrombosis, recurrent fetal wastage, coronary artery disease, valvular heart disease, dilated cardiomyopathy, pulmonary artery hypertension, and intracardiac thrombus. Most commonly mitral valve is affected followed by aortic and then tricuspid valve. Read More

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http://dx.doi.org/10.1111/echo.14254DOI Listing
January 2019

Prevalence and associations of anti-phosphatidylserine/prothrombin antibodies with clinical phenotypes in patients with primary antiphospholipid syndrome: aPS/PT antibodies in primary antiphospholipid syndrome.

Thromb Res 2018 Dec 29;174:141-147. Epub 2018 Dec 29.

Department of Medicine, Division of Rheumatology, The Ottawa Hospital, University of Ottawa, 1967 Riverside Drive, K1H 7W9 Ottawa, ON, Canada. Electronic address:

Objective: The clinical significance of anti-phosphatidylserine/prothrombin (aPS/PT) in antiphospholipid syndrome (APS) is still controversial. We assessed the prevalence of aPS/PT antibodies, their association with other anti-phospholipid antibodies (aPL) and with different APS clinical phenotypes.

Methods: We included 95 primary APS patients according to the Sydney classification criteria, and patients with thrombocytopenia and/or hemolytic anemia who also fulfilled the serological APS criteria. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.12.023DOI Listing
December 2018
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Clinical and immunological features of antiphospholipid syndrome in the elderly: a retrospective national multicentre study.

Rheumatology (Oxford) 2019 Jan 3. Epub 2019 Jan 3.

Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris.

Objective: APS mainly affects women who are of child-bearing age. We aimed to describe the clinical and immunological features of APS patients diagnosed after the age of 60.

Methods: The Elderly-Phospholipid study is a national, multicentre, retrospective study involving all APS (2006 Miyakis criteria) patients followed in five French tertiary university centres including four national referral lupus and APS centres. Read More

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https://academic.oup.com/rheumatology/advance-article/doi/10
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http://dx.doi.org/10.1093/rheumatology/key437DOI Listing
January 2019
3 Reads
4.475 Impact Factor

Splenic Infarction as Only Manifestation of Antiphospholipid Syndrome in a Patient With Rheumatoid Arthritis.

J Clin Rheumatol 2018 Dec 28. Epub 2018 Dec 28.

From the Department of Emergency and Organ Transpantations, Rheumatology Unit, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1097/RHU.0000000000000964DOI Listing
December 2018
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Should aPS/PT Be Incorporated into the Routine Serological Tests in the Diagnosis of Antiphospholipid Syndrome?

J Rheumatol 2019 Jan;46(1):114-116

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.3899/jrheum.171402DOI Listing
January 2019
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Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature.

Semin Arthritis Rheum 2018 Dec 4. Epub 2018 Dec 4.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 865 Northern Boulevard, Suite 302, Great Neck, NY 11021, USA.

Introduction: Thrombotic microangiopathy (TMA) is a life-threatening, albeit infrequent, complication of systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS). Recommendations for the treatment of SLE- and APS-related secondary TMA are currently based solely on case reports and expert opinion. Unfortunately, interventions may not yield timely results or effectively halt the progression of TMA. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.11.005DOI Listing
December 2018
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Ischemic stroke in a young woman with anti-phosphatidylserine/prothrombin (aPS/PT) complex antibody: a case report.

J Neurol Sci 2018 Dec 7;397:77-79. Epub 2018 Dec 7.

Department and institution, Department of Neurology, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-ku Kobe, Hyogo 650-0047, Japan.

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http://dx.doi.org/10.1016/j.jns.2018.12.012DOI Listing
December 2018
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Obstetric APS and thrombosis; modelling future risks.

BJOG 2018 Dec 28. Epub 2018 Dec 28.

Department of Obstetrics and Gynaecology, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.

In order to diagnose obstetric-history-based antiphospholipid syndrome (Ob-APS), it is recommended that women with recurrent pregnancy loss (RPL), a history of severe preeclampsia, eclampsia or features consistent with placental insufficiency (Placental syndrome, PS) should be tested for antiphospholipid antibodies (aPL) (Miyakis S et al. J Thromb Haemost 2006;4:295). The systemic biology towards these pregnancy-related complications is still incompletely understood but includes an interplay between endothelial cell stimulation, (secondary) platelet activation, throphoblast impairment or Toll-like receptor-induced innate immunity activation. Read More

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http://dx.doi.org/10.1111/1471-0528.15595DOI Listing
December 2018
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Catastrophic Antiphospholipid Antibody Syndrome After Cobra Bite in a Patient With Systemic Lupus Erythematosus.

J Clin Rheumatol 2018 Dec 20. Epub 2018 Dec 20.

From the Department of Dermatology, Dr. Vasantrao Pawar Medical College, Hospital & Research Centre, Nashik, India.

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http://dx.doi.org/10.1097/RHU.0000000000000969DOI Listing
December 2018
1 Read

[Comparison of the etiological constitution of two and three or more recurrent miscarriage].

Zhonghua Fu Chan Ke Za Zhi 2018 Dec;53(12):855-859

Center for Reproductive Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

To compare the etiological constitution of recurrent miscarriage (RM) between patients with consecutive two and three or more miscarriages through combining the routine examination results and embryonic karyotype. Patients with a history of two or more consecutive clinical miscarriages (≤12 weeks of gestation) consulting in the RM clinic of the First Affiliated Hospital of Sun Yat-sen University from March 2011 to January 2016 were collected. Six hundred and ninety-six with detailed history recorded, routine clinical examinations of RM and at least once embryonic karyotype were ultimately enrolled in this study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2018.12.010DOI Listing
December 2018
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Antiplatelet and Anticoagulant Agents for Secondary Prevention of Thromboembolic Events in People With Antiphospholipid Syndrome.

Stroke 2018 Mar;49(3):e41-e42

From the Department of Hygiene and Dietetics (M.M.B., W.S.), Systematic Reviews Unit - Polish Cochrane Branch (M.M.B., M.K., M.J.S.), 2nd Department of Internal Medicine, Department of Allergy and Immunology (M.C.-L.), and Institute of Cardiology (A.U.), Jagiellonian University Medical College, Krakow, Poland.

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http://dx.doi.org/10.1161/STROKEAHA.117.019900DOI Listing
March 2018
2 Reads

Acute Pulmonary Embolism in a Teenage Female - A Case Report.

J Crit Care Med (Targu Mures) 2018 Jul 1;4(3):101-104. Epub 2018 Jul 1.

Emergency Clinical County Hospital Tîrgu Mureș, Pediatrics Clinic No. 1, Tîrgu Mureş, Romania.

Thrombophilia represents a tendency towards excessive blood clotting and the subsequent development of venous thromboembolism (VTE). VTE is a rare condition in children that comprises both deep venous thrombosis (DVT) and pulmonary embolism (PE). This paper reports the case of a 16-year-old girl, admitted to the Pediatrics Clinic No. Read More

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http://content.sciendo.com/view/journals/jccm/4/3/article-p1
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http://dx.doi.org/10.2478/jccm-2018-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294988PMC
July 2018
4 Reads

Clinical Phenotype of a First Unprovoked Acute Pulmonary Embolism Associated with Antiphospholipid Antibody Syndrome.

Tuberc Respir Dis (Seoul) 2019 Jan;82(1):53-61

Department of Pulmonary and Critical Care Medicine, Center for Pulmonary Hypertension and Venous Thrombosis, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Antiphospholipid antibody syndrome (APS), an important cause of acquired thrombophilia, is diagnosed when vascular thrombosis or pregnancy morbidity occurs with persistently positive antiphospholipid antibodies (aPL). APS is a risk factor for unprovoked recurrence of pulmonary embolism (PE). Performing laboratory testing for aPL after a first unprovoked acute PE is controversial. Read More

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http://dx.doi.org/10.4046/trd.2018.0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304333PMC
January 2019

Response to: 'OCTA, a sensitive screening for asymptomatic retinopathy, raises alarm over systemic involvements in patients with SLE' by Mizuno et .

Ann Rheum Dis 2018 Dec 20. Epub 2018 Dec 20.

Rheumatology, Allergology and Clinical Immunology, Department of 'Medicina dei Sistemi', University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1136/annrheumdis-2018-214796DOI Listing
December 2018
3 Reads

Antiphospholipid syndrome combined with acute coronary syndrome: Case report.

Medicine (Baltimore) 2018 Dec;97(51):e13613

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Rationale: Antiphospholipid syndrome (APS) combined with acute coronary syndrome (ACS) is rarely reported.

Patient Concerns: One male patient with APS was admitted to our hospital, who had recent unstable angina (UA).

Diagnosis: The preliminary diagnosis of ACS and UA (BraunwaldiB) was then made. Read More

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http://dx.doi.org/10.1097/MD.0000000000013613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320188PMC
December 2018
3 Reads

Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort.

Arthritis Res Ther 2018 Dec 19;20(1):280. Epub 2018 Dec 19.

Complexo Hospitalario Universitario de Vigo, Vigo, Spain.

Background: The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

Methods: All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations.

Results: In total 3215 patients were included. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1776-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299951PMC
December 2018
5 Reads

Intravenous immunoglobulins for rheumatic disorders and thromboembolic events-a case series and review of the literature.

Immunol Res 2018 Dec 19. Epub 2018 Dec 19.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

To report the temporal association between a series of thromboembolic events and intravenous immunoglobulin infusion in patients with rheumatic diseases, and to review the literature on the subject. The clinical presentation, course, and outcome of thromboembolic events occurring post-immunoglobulin infusion in nine patients is described. A web-based literature review using the PubMed database from 1996 to 2017 was performed, searching for the keywords: thrombosis, thromboembolism, intravenous immunoglobulin, pulmonary embolism, deep vein thrombosis, cerebrovascular event, and acute myocardial infarction. Read More

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http://dx.doi.org/10.1007/s12026-018-9047-yDOI Listing
December 2018
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[Case series and clinical analysis of 14 cases of catastrophic antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1033-1038

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Objective: Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a special subtype of antiphospholipid syndrome (APS) characterized by multiple intravascular thrombosis involving multiple organs systems or tissues simultaneously or continuously, high titer antiphospholipid antibodies and high mortality rate. This article's aims was to analyze the clinical manifestation, laboratory examination and treatment therapy of CAPS for the purpose of improving the understanding, diagnosis and treatment of the disease in clinical practice.

Methods: Retrospective analysis and descriptive statistics were applied to the clinical manifestations and laboratory findings of 14 CAPS cases from APS Shanghai Database (APS-SH) with catastrophic antiphospholipid. Read More

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December 2018

[Increased serum soluble-endoglin level and its clinical significance in antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1027-1032

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To detect the serum levels of soluble endothelial glycoprotein endoglin (s-Eng) in patients with antiphospholipid syndrome (APS) and to evaluate the correlation between s-Eng levels and clinical features and laboratory parameters.

Methods: The levels of serum s-Eng were measured by enzyme linked immunosorbent assay (ELISA) in 139 patients with APS, 44 patients with SLE but no APS, 37 patients with primary Sjögren's syndrome (pSS), 23 patients with Bechet's disease (BD), 22 patients with systemic sclerosis (SSc) and 22 persistent anticardiolipin antibody (aCL) positive individuals without SLE or APS (simply aCL positive group) and 87 health controls (HC) without any auto-immune diseases. These APS patients included 64 primary APS patients and 75 APS patients secondary to SLE. Read More

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December 2018
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[Diagnosis and treatment of antiphospholipid antibody-related recurrent spontaneous abortion and analysis of therapeutic drugs and pregnancy outcome in 75 patients with antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):956-961

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Recurrent spontaneous abortion is one of the common complications in women of childbearing age during pregnancy. The immune factor accounts for a large proportion of many causes. Antiphospholipid antibody syndrome is the most common type of acquired thrombophilia disease. Read More

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December 2018
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Combined central retinal artery and vein occlusion; first manifestation of lupus in a pediatric patient.

Arch Soc Esp Oftalmol 2018 Dec 14. Epub 2018 Dec 14.

Departamento de Retina y Vítreo, Hospital General de México «Dr. Eduardo Liceaga», Ciudad de México, Estados Unidos Mexicanos. Electronic address:

Combined central retinal artery and vein occlusion is uncommon in adults and even more so in young people. The main origins are vasculitis and thromboembolic disorders. The prognosis is poor due to irreversible visual loss and the development of neovascular glaucoma (NVG). Read More

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http://dx.doi.org/10.1016/j.oftal.2018.10.009DOI Listing
December 2018
1 Read

Ocular Posterior Segment Involvement in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus.

Ocul Immunol Inflamm 2018 Dec 17:1-6. Epub 2018 Dec 17.

d Department of Ophthalmology , Marmara University School of Medicine , Istanbul , Turkey.

Purpose: To describe posterior segment findings of antiphospholipid syndrome (APS) and compare them with systemic lupus erythematosus (SLE).

Methods: A total of 11 patients with primary APS, 29 secondary APS patients, and 29 SLE patients without APS were included. All patients were referred from rheumatology clinic for detailed ophthalmologic examination. Read More

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http://dx.doi.org/10.1080/09273948.2018.1552759DOI Listing
December 2018
2 Reads

Anticoagulation in patients with concomitant lupus nephritis and thrombotic microangiopathy: a multicentre cohort study.

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

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http://dx.doi.org/10.1136/annrheumdis-2018-214559DOI Listing
December 2018

Co-existing Bilateral Pulmonary Embolism and Intra-cardiac Mass: A Case of Catastrophic Antiphospholipid Syndrome-like Disease.

Cureus 2018 Oct 10;10(10):e3438. Epub 2018 Oct 10.

Internal Medicine, Shifa International Hospital, Islamabad, PAK.

Young patients presenting with thrombotic events like pulmonary embolism and cardiological phenomenon such as presence of an intracardiac mass, without any underlying risk factors, should be promptly investigated for thrombophilias including antiphospholipid syndrome (APLS). This case is reported to highlight rare occurrence of co-existing bilateral extensive pulmonary embolism and an intra-cardiac mass at presentation of antiphospholipid syndrome as well as progression to near catastrophic APLS. Read More

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https://www.cureus.com/articles/15150-co-existing-bilateral-
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http://dx.doi.org/10.7759/cureus.3438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289563PMC
October 2018
1 Read

Relapsing Evans syndrome and systemic lupus erythematosus with antiphospholipid syndrome treated with Bortezomib in combination with plasma exchange.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of the Mosaics of Autoimmunity, Saint-Petersburg University, 7/9 Universitetskaya Emb., Saint- Petersburg 199034, Russia.

Relapsing Evans syndrome (ES) and systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome (APS) is very rare association. Coexistence of these syndromes is potentially fatal and require high-dose combined immunosuppressive therapy. We describe a case of successful use of Bortezomib and plasma exchange in a patient with ES and APS refractory to standard therapy. Read More

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http://dx.doi.org/10.1016/j.clim.2018.12.010DOI Listing
December 2018

The Differences Between Childhood and Adult Onset Antiphospholipid Syndrome.

Front Pediatr 2018 27;6:362. Epub 2018 Nov 27.

Department of Rheumatology, University College London, London, United Kingdom.

Antiphospholipid syndrome (APS) is a rare autoimmune disease of unknown etiology that represents a leading cause of acquired thromboembolism and recurrent miscarriage. It is characterized by the persistent elevated presence of pathogenic antiphospholipid auto-antibodies directed against cardiolipin, ß2-glycoprotein-I, and/or a positive lupus anticoagulant test. As with many autoimmune disorders, the pathogenesis of APS is believed to be the result of a complex interaction between environmental triggers and genetic predisposition. Read More

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http://dx.doi.org/10.3389/fped.2018.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277799PMC
November 2018
1 Read

Presence of Immune Complexes of IgG/IgM Bound to B2-glycoprotein I Is Associated With Non-criteria Clinical Manifestations in Patients With Antiphospholipid Syndrome.

Front Immunol 2018 20;9:2644. Epub 2018 Nov 20.

Immunology Department, Hospital 12 de Octubre, Madrid, Spain.

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of both clinical (thromboembolic events or pregnancy morbidity) and laboratory (antiphospholipid antibodies, aPL) manifestations. Despite their importance, several clinical manifestations strongly associated with APS such as livedo reticularis (LR), thrombocytopenia, sicca-ophthalmic(sicca), heart, or neurological manifestations are not included in the APS clinical classification criteria. Circulating immune complexes (CIC) formed by Beta-2-glycoprotein I (B2GPI) and aPL (B2-CIC) have been described and their presence has been related with thrombotic events. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256181PMC
November 2018
6 Reads

Effectiveness and Safety of Rituximab in Systemic Lupus Erythematosus: A Case Series Describing the Experience of 2 Centers.

Reumatol Clin 2018 Dec 3. Epub 2018 Dec 3.

Servicio de Reumatología, Hospital del Mar/Parc de Salut-Mar/IMIM, Barcelona, España.

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs and systems. B cells have a critical role in the pathogenesis of SLE. Rituximab (RTX) is a drug composed of chimeric monoclonal antibodies against the CD20 protein, producing a depletion of B lymphocytes. Read More

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http://dx.doi.org/10.1016/j.reuma.2018.08.012DOI Listing
December 2018
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Sex Hormones and Prolactin Levels and Their Association with Anti Cardiolipin Antibody in Patients with Systemic Lupus Erythematosus.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):336-345. Epub 2018 Aug 12.

Department of Internal Medicine, Lorestan University of Medical Sciences, khorramabad, Iran.

Pathogenesis of systemic lupus erythematosus (SLE) is complex and multi-factorial. Among various suggested mechanisms for the disease, the hormonal theory has been considered as one of the most important mechanisms. Recently, the association of sex hormones with manifestations of antiphospholipid antibody syndrome (APLS) has been hypothesized. Read More

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http://dx.doi.org/10.18502/ijaai.v17i4.93DOI Listing
August 2018
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Antiphospholipid Syndrome and the Neurologist: From Pathogenesis to Therapy.

Front Neurol 2018 26;9:1001. Epub 2018 Nov 26.

Section of Neurology, Department of Translational Medicine University of Eastern Piedmont, Novara, Italy.

Antiphospholipid syndrome (APS) is an autoimmune antibody-mediated condition characterized by thrombotic events and/or pregnancy morbidity in association with persistent positivity to antiphospholipid antibodies (aPL). The nervous system is frequently affected, as intracranial vessels are the most frequent site of arterial pathology. Over the course of years, many other neurological conditions not included in the diagnostic criteria, have been associated with APS. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01001
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http://dx.doi.org/10.3389/fneur.2018.01001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275383PMC
November 2018
3 Reads

Galectin-9 reflects the interferon signature and correlates with disease activity in systemic autoimmune diseases.

Ann Rheum Dis 2018 Dec 8. Epub 2018 Dec 8.

Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2018-214651DOI Listing
December 2018
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Efficacy of dual antiplatelet therapy for preventing recurrence of arterial thrombosis in patients with antiphospholipid syndrome.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but the recurrence rate is still high. Dual antiplatelet therapy (DAPT) has been shown to be effective for the prevention of acute coronary syndrome or stroke. The objective of this study was to evaluate the efficacy of DAPT for the prevention of thrombosis recurrence in APS patients with history of arterial thrombosis. Read More

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http://dx.doi.org/10.1093/rheumatology/key340DOI Listing
November 2018
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Monitoring disease activity in systemic lupus erythematosus with single-molecule array digital ELISA quantification of serum interferon-α.

Arthritis Rheumatol 2018 Dec 3. Epub 2018 Dec 3.

Sorbonne Université, Inserm UMRS1135, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Assistance Publique-Hôpitaux de Paris, Groupement Hospitalier Pitié-Salpêtrière, Département d'ImmunologieParis, France.

Objectives: No simple or standardized assay is available to quantify interferon-α (IFNα) in routine clinical practice. Single-molecule-array (Simoa) digital enzyme-linked immunosorbent assay (ELISA) technology enables direct IFNα quantification at fg/mL concentrations. This study was undertaken to assess IFNα digital ELISA diagnostic performances to monitor systemic lupus erythematosus (SLE) activity. Read More

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http://dx.doi.org/10.1002/art.40792DOI Listing
December 2018
6 Reads

Anticoagulating patients with high-risk acquired thrombophilias.

Authors:
Leslie Skeith

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):439-449

Division of Hematology and Hematological Malignancies, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Canada; and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.

Antiphospholipid syndrome (APS), heparin-induced thrombocytopenia, and paroxysmal nocturnal hemoglobinuria are 3 acquired thrombophilias that carry a high risk of venous and arterial thromboembolism. Management of these conditions has largely included anticoagulation with a vitamin K antagonist after an initial period of a parenteral anticoagulant, for as long as the thrombotic risk is still present. The available evidence for the use of direct oral anticoagulants (DOACs) is limited and primarily consists of case series and cohort studies, which are summarized in this chapter. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246016PMC
November 2018
1 Read

The rheumatology/hematology interface: CAPS and MAS diagnosis and management.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):313-317

Department of Medicine, Division of Hematology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Catastrophic antiphospholipid antibody syndrome (CAPS) and macrophage activation syndrome (MAS) are both life-threatening hematologic disorders that infrequently afflict patients with rheumatologic disease. CAPS is characterized by fulminant multiorgan damage related to small vessel thrombosis in the setting of persistent antiphospholipid antibodies. It can occur in patients with rheumatologic diseases such as systemic lupus erythematosus but can also affect patients who do not have rheumatologic disease. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245968PMC
November 2018
1 Read

[Antithrombotics in the management of thrombotic antiphospholipid syndrome].

Rev Med Suisse 2018 Dec;14(630):2198-2201

Service d'angiologie et hémostase, HUG et Faculté de médecine, 1211 Genève 14.

The thrombotic antiphospholipid syndrome is defined by persistent antiphospholipid antibodies and vascular thrombosis. Recommendations for the secondary thrombotic prevention in the thrombotic antiphospholipid syndrome are weak, based on a low-to-moderate quality of evidence. When the initial event leading to diagnosis is a venous thrombosis, the prevention of recurrence of a thrombotic event is based on anticoagulation with a vitamin K antagonist. Read More

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December 2018
5 Reads