488,363 results match your criteria Antioxidants Basel Switzerland[Journal]


Induction of endoplasmic reticulum stress might be responsible for defective autophagy in cadmium-induced prostate carcinogenesis.

Toxicol Appl Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology, Louisville, KY, USA. Electronic address:

Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The present study suggests that chronic Cd exposure induces endoplasmic reticulum (ER) stress that triggers the phosphorylation of stress transducers [protein kinase R-like ER Kinase- (PERK), eukaryotic translation initiation factor 2-alpha- (eIF2-α) and Activating Transcription Factor 4 -(ATF-4)], resulting in defective autophagy that protects Cd-exposed RWPE-1 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X193013
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http://dx.doi.org/10.1016/j.taap.2019.04.012DOI Listing
April 2019
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Optimization of Cultivation Conditions of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) for the Highest Antioxidant Activity and Antioxidant Content.

Int J Med Mushrooms 2019 ;21(4):353-366

Institute of Food Biotechnology and College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou, Guangdong, China.

Ganoderma lucidum is a famous medicinal mushroom that is rich in antioxidants. The content of antioxidant components of grains can be effectively improved by G. lucidum as the fermenting strain. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030338DOI Listing
January 2019
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Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study.

J Korean Med Sci 2019 Apr 22;34(15):e117. Epub 2019 Apr 22.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Removal of uremic toxins such as indoxyl sulfate by AST-120 is known to improve renal function and delay the initiation of dialysis in patients with advanced chronic kidney disease. However, it is unclear whether the addition of AST-120 to conventional treatments is effective in delaying the progression of renal dysfunction in patients with diabetic nephropathy.

Methods: A total of 100 patients with type 2 diabetes and renal dysfunction (serum creatinine levels ranging from 1. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e117DOI Listing

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu.

ACS Omega 2019 Mar 15;4(3):5356-5366. Epub 2019 Mar 15.

Department of Physical and Environmental Science, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada.

Understanding the factors that give rise to tau aggregation and reactive oxygen species (ROS) is the key aspect in Alzheimer's disease pathogenesis. Microtubule (MT) binding repeats of tau protein were suggested to play a critical role in tau aggregation. Here, we show that the interaction of Cu with full-length MT binding repeats R1-R4 leads to the aggregation, and a Cys-based redox chemistry is critically involved in tau aggregation leading to disulfide-bridge dimerization of R2 and R3 and further aggregation into a fibrillar structure. Read More

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http://pubs.acs.org/doi/10.1021/acsomega.8b03595
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http://dx.doi.org/10.1021/acsomega.8b03595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463671PMC
March 2019
1 Read

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance.

Proc Natl Acad Sci U S A 2019 Apr 18. Epub 2019 Apr 18.

Department of Molecular Oncology, BC Cancer, Vancouver V5Z 1L3, Canada;

The family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic RAS transformation are well documented, including constitutive signaling through the RAF-MEK-ERK proproliferative pathway as well as the PI3K-AKT prosurvival pathway. Notably, control of redox balance has also been proposed to contribute to RAS transformation. Read More

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http://dx.doi.org/10.1073/pnas.1821323116DOI Listing

Clinical utility of genomic analysis in adults with idiopathic liver disease.

J Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

Background & Aims: Adult patients suffering from liver disease of unknown cause represent an understudied and underserved population. The use of whole-exome sequencing (WES) for the assessment of a broader spectrum of non-oncological diseases, among adults, remains poorly studied. We assessed the utility of WES in the diagnosis and management of adults with unexplained liver disease despite comprehensive evaluation by a hepatologist and with no history of alcohol overuse. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193011
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http://dx.doi.org/10.1016/j.jhep.2019.01.036DOI Listing
April 2019
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Combined effect of natural antioxidants and antimicrobial compounds during refrigerated storage of nitrite-free frankfurter-type sausage.

Food Res Int 2019 Jun 27;120:839-850. Epub 2018 Nov 27.

Centro Tecnológico de la Carne de Galicia, Parque Tecnológico de Galicia, rúa Galicia n° 4, San Cibrao das Viñas, Ourense 32900, Spain. Electronic address:

The effects of nisin (200 and 400 ppm), ε-polylysine (0.1 and 0.2%) and chitosan (0. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.11.048DOI Listing

Chemistry, pharmacology and new trends in traditional functional and medicinal beverages.

Food Res Int 2019 Jun 3;120:478-503. Epub 2018 Nov 3.

Programa de Pós-graduação em Engenharia Química, Universidade de Uberaba-UNIUBE, Campus Aeroporto, Av. Nenê Sabino 1802, CEP 38055-500 Uberaba, MG, Brazil. Electronic address:

Functional and medicinal beverages consumption plays an important role in human health, considering that metabolites, with a wide range of pharmacological effects, are inserted in the human diet. Nowadays, the most consumed beverages are obtained from Camellia sinensis leaves and coffee grain processing, and contain different classes of polyphenols and phenolic acids in their phytochemical composition. Besides C. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.10.091DOI Listing

Japanese, Mediterranean and Argentinean diets and their potential roles in neurodegenerative diseases.

Food Res Int 2019 Jun 10;120:464-477. Epub 2018 Nov 10.

Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, Burjassot, València, Spain. Electronic address:

Environmental factors are responsible of cellular senescence and processes found in the development of cognitive disorders. The aim of this paper is to compare benefits of the Japanese, Mediterranean, and Argentinian Diet on the onset or prevention of senile dementia (SD) and Alzheimer's Disease (AD). Special focus was on the effects of specific compounds such as polyunsaturated fatty acids (PUFAs), antioxidants, and saturated and trans fatty acids. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.10.090DOI Listing

Protective effect of hydroxytyrosol and rosemary extract in a comparative study of the oxidative stability of Echium oil.

Food Chem 2019 Aug 27;290:316-323. Epub 2019 Mar 27.

Department of Production and Characterization of Novel Foods, Institute of Food Science Research (CIAL, CSIC-UAM), C/ Nicolas Cabrera 9, 28049 Madrid, Spain. Electronic address:

The oxidative stability of Echium oil has been studied by two accelerated oxidation methodologies namely Rancimat and differential scanning calorimetry at selected temperatures in the range 50-110 °C. Kinetic analyses have provided Arrhenius parameters, oxidative stability indexes (OSI), temperature coefficients (t), Q and OSI at 20 °C (OSI) for both methodologies focussing on secondary and tertiary oxidation products. Peroxide, p-anisidine and polar compounds values have been measured to characterize from primary to tertiary oxidation products. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.03.141DOI Listing

Polyphenols, from Antioxidants to Anti-Inflammatory Molecules: Exploring a Network Involving Cytochromes P450 and Vitamin D.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.

Inflammatory response represents one of the main mechanisms of healing and tissue function restoration. On the other hand, chronic inflammation leads to excessive secretion of pro-inflammatory cytokines involved in the onset of several diseases. Oxidative stress condition may contribute in worsening inflammatory state fall, increasing reactive oxygen species (ROS) production and cytokines release. Read More

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http://dx.doi.org/10.3390/molecules24081515DOI Listing

Comparative Transcriptomic Studies on a Cadmium Hyperaccumulator and Its Non-Tolerant Counterpart .

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

Many plants growing in mining areas exhibit high levels of cadmium (Cd) tolerance and accumulation, and thus are ideal organisms for comparative studies on molecular mechanisms of Cd hyperaccumulation. However, transcriptomic studies of hyperaccumulative plants in Violaceae are rare. is an amazing Cd hyperaccumulator in metalliferous areas of China, whereas its relative is a non-tolerant accumulator that resides at non-metalliferous sites. Read More

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http://dx.doi.org/10.3390/ijms20081906DOI Listing

On the Origin and Fate of Reactive Oxygen Species in Plant Cell Compartments.

Antioxidants (Basel) 2019 Apr 17;8(4). Epub 2019 Apr 17.

Department of Biochemistry, Palacký University in Olomouc, Šlechtitelů 27,CZ-78371 Olomouc, Czech Republic.

Reactive oxygen species (ROS) have been recognized as important signaling compoundsof major importance in a number of developmental and physiological processes in plants. Theexistence of cellular compartments enables efficient redox compartmentalization and ensuresproper functioning of ROS-dependent signaling pathways. Similar to other organisms, theproduction of individual ROS in plant cells is highly localized and regulated bycompartment-specific enzyme pathways on transcriptional and post-translational level. Read More

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http://dx.doi.org/10.3390/antiox8040105DOI Listing

Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies?

Antioxidants (Basel) 2019 Apr 17;8(4). Epub 2019 Apr 17.

Universitat Jaume I, Unitat predepartamental de Medicina, Avda/Sos Baynat, S/N, 12071 Castellón de la Plana, Spain.

Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on anti-vascular endothelial growth factor (VEGF) strategies, antioxidants or anti-inflammatory therapies are only partially effective or show some adverse side effects. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health. Read More

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https://www.mdpi.com/2076-3921/8/4/104
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http://dx.doi.org/10.3390/antiox8040104DOI Listing
April 2019
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SA and AM symbiosis modulate antioxidant defense mechanisms and asada pathway in chickpea genotypes under salt stress.

Ecotoxicol Environ Saf 2019 Apr 15;178:66-78. Epub 2019 Apr 15.

Department of Botany, Panjab University, Chandigarh, 160014, India. Electronic address:

Salt stress disturbs redox homeostasis by perturbing equilibrium between generation and removal of reactive oxygen species (ROS), which alters the normal metabolism of plants through membrane damage, lipid peroxidation and denaturation of proteins. Salicylic acid (SA) seed priming and arbuscular mycorrhizal (AM) fungi impart salt tolerance in legumes by maintaining redox balance. The present investigation focused on the relative and combined applications of SA and Rhizoglomus intraradices in scavenging ROS in Cicer arietinum L. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.025DOI Listing
April 2019
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Elevated atmospheric CO might increase the health risk of long-term ingestion of leafy vegetables cultivated in residual DDT polluted soil.

Chemosphere 2019 Apr 6;227:289-298. Epub 2019 Apr 6.

Institute of Environmental Microbiology, College of Resources and Environment, Fujian Agriculture & Forestry University, Fuzhou, 350002, China. Electronic address:

Residual dichlorodiphenyltrichloroethane (DDT) in the environment and a continuously increasing atmospheric carbon dioxide (CO) concentration are two issues that have received a lot of attention. This study was conducted using a pot experiment to investigate the interactive effects of elevated CO and DDT on the uptake of DDT, the physiological responses and the resulting health risks in three vegetables. These vegetables included Brassica juncea var. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.024DOI Listing

Physicochemical and microbiological characteristics of honey obtained through sugar feeding of bees.

J Food Sci Technol 2019 Apr 19;56(4):2267-2277. Epub 2019 Mar 19.

3School of Bioresource, Graduate School, Andong National University, Andong, 760-749 Republic of South Korea.

This study was planned to characterize the physicochemical and antioxidant properties, and microbiological quality of honey obtained from the sandbar pumpkin field. In this study, four sugar supplemented and one control (without sugar fed) honey sample was used. Results revealed that all samples exhibited appropriate maturity considering their low moisture content (~ 19%) and high total solids (~ 80%) and TSS (~ 79%). Read More

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http://dx.doi.org/10.1007/s13197-019-03714-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443748PMC

Tuna red meat hydrolysate as core and wall polymer for fish oil encapsulation: a comparative analysis.

J Food Sci Technol 2019 Apr 14;56(4):2134-2146. Epub 2019 Mar 14.

1ICAR-Central Institute of Fisheries Technology, Kochi, 682029 India.

Microencapsulation by spray drying is a well-accepted technique for fish oil stabilization. However, severe operational conditions during atomisation destabilise the emulsion, leading to capsule collapse and induction of auto-oxidation. Hence, use of food grade cross-linkers to strengthen the wall material and antioxidants to prevent lipid oxidation has been suggested. Read More

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http://dx.doi.org/10.1007/s13197-019-03694-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443975PMC

Vacuum drying application to maqui ( [Mol] Stuntz) berry: Weibull distribution for process modelling and quality parameters.

J Food Sci Technol 2019 Apr 4;56(4):1899-1908. Epub 2019 Mar 4.

1Department of Food Engineering, University of La Serena, Raúl Bitrán 1305, Box 599, La Serena, Chile.

In this study, maqui berries were subjected to vacuum drying at 40-80 °C to assess and compare the effect on proximate composition, dietary fiber, phenolic and flavonoid compounds, antioxidant capacity and sugar content. The Weibull model was used for describing the vacuum drying process. The results indicated that the highest retention of total phenolic content (TPC) and total flavonoid content (TFC) was obtained after drying at 80 °C. Read More

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http://dx.doi.org/10.1007/s13197-019-03653-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443766PMC

Effect of winemaking on phenolic profile, colour components and antioxidants in (sin. ) wine.

J Food Sci Technol 2019 Apr 20;56(4):1841-1853. Epub 2019 Feb 20.

1Department of Food Technology and Biotechnology, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia.

or is a Croatian autochthonous grape variety which is a parent of the America's most popular variety or Italian . The aim of this study was to investigate the dynamics of extraction of phenolics and changes in antioxidant activity of the samples collected during maceration of grapes processed using two different macerating enzymes. According to the obtained results it can be concluded that wines from grapes are great source of bioactive phenolics although differences in phenolic profiles between control and enzyme-treated wines were detected. Read More

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http://link.springer.com/10.1007/s13197-019-03638-4
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http://dx.doi.org/10.1007/s13197-019-03638-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443773PMC
April 2019
2 Reads

Onion ( L.) is potentially a good source of important antioxidants.

J Food Sci Technol 2019 Apr 13;56(4):1811-1819. Epub 2019 Feb 13.

3Kuwait Institute for Scientific Research, P.O. Box 24884, 13109 Safat, Kuwait.

Six different cultivars of onions available in the Kuwaiti market were analyzed for various physic-chemical properties, such as, moisture content, sugar composition, TBARS as malondialdehyde, total phenolic content, as well as trolox equivalent antioxidant capacity, these cultivars comprised of US onions white, US onions yellow, Indian onions red, Egyptian onions red, New Zealand onions golden and Saudi onions white. Layers from each onion bulb were manually cut and separated into three nearly equal portions, i.e. Read More

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http://dx.doi.org/10.1007/s13197-019-03625-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443770PMC

Flavonoids: New Frontier for Immuno-Regulation and Breast Cancer Control.

Antioxidants (Basel) 2019 Apr 16;8(4). Epub 2019 Apr 16.

Department Physiology, Michigan State University, East Lansing, MI 48824, USA.

Breast cancer (BC) remains the second most common cause of cancer-related deaths in women in the US, despite advances in detection and treatment. In addition, breast cancer survivors often struggle with long-term treatment related comorbidities. Identifying novel therapies that are effective while minimizing toxicity is critical in curtailing this disease. Read More

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http://dx.doi.org/10.3390/antiox8040103DOI Listing

Bioactive Compounds and Antioxidant Activity of Mango Peel Liqueurs ( L.) Produced by Different Methods of Maceration.

Antioxidants (Basel) 2019 Apr 16;8(4). Epub 2019 Apr 16.

Department of Food Technology, Instituto Federal do Sertão Pernambucano, Petrolina PE 56314-522, Brazil.

The present work had the objective of producing liqueurs from mango peels (varieties "Haden" and "Tommy Atkins") by processes of alcoholic maceration and maceration with pectinase, as well as to evaluate bioactive compounds by reversed-phase high-performance liquid chromatography coupled to diode array detection and fluorescence-detection (RP-HPLC/DAD/FD) and in vitro antioxidant activity (AOX), for by-product potential reuse. Alcoholic maceration in wine ethanol (65% /) produced liqueurs with higher phytochemical and AOX content. Maceration with pectinase resulted in liqueurs with higher quercetin-3--glucopyranoside content. Read More

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http://dx.doi.org/10.3390/antiox8040102DOI Listing

Effects of Freezing Method and Antioxidants on Lipid Oxidation in Turkey Sausage .

J Food Prot 1988 Nov;51(11):878-882

Departments of Animal Science and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1.

Rosemary oleoresin (200 ppm) was compared to a commercial antioxidant mixture of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) (200 ppm) and citric acid in frozen and freeze dried breakfast sausages prepared with 18% mechanically deboned turkey meat. Analysis for malondialdehyde (MDA) revealed that both antioxidant treatments inhibited lipid oxidation during 5 weeks of storage. Rosemary oleoresin was comparable in activity to the commercial antioxidant mixture in the freeze dried products but not in the frozen products. Read More

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http://jfoodprotection.org/doi/abs/10.4315/0362-028X-51.11.8
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http://dx.doi.org/10.4315/0362-028X-51.11.878DOI Listing
November 1988
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Revelation of microalgae's lipid production and resistance mechanism to ultra-high Cd stress by integrated transcriptome and physiochemical analyses.

Environ Pollut 2019 Apr 8;250:186-195. Epub 2019 Apr 8.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. Electronic address:

The ultra-high Cd polluted environment is a special habitat in nature. Analysis of the biological adaptation and resistance mechanism of Auxenochlorella protothecoides UTEX234 to ultra-high Cd stress would offer some inspiring understanding on Cd detoxification mechanism and help discovering highly active bioremediation agents. In this study, integrated analyses of the transcriptome, multi-physiological and biochemical data and fatty acid profilings of UTEX2341 were performed for the first time. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.018DOI Listing

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1566-1570

Visual Function Core, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States.

Purpose: To test the hypothesis that oxidative stress in the outer retina (OR = distance from external limiting membrane to the retinal pigment epithelium-choroid boundary) can be detected by using antioxidants (AOs) to correct an impaired light-evoked response as measured by optical coherence tomography (OCT).

Methods: C57BL/6J mice were maintained in the dark for ∼20 hours and studied by OCT before and after 1 hour of light exposure. OR thickness in dark or light was measured, and the light-dark difference (i. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-26164DOI Listing
April 2019
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Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants.

ACS Appl Mater Interfaces 2019 Apr 17. Epub 2019 Apr 17.

Graphene quantum dots (GQDs) have recently been employed in various fields including medicine as antioxidants, primarily due to favorable biocompatibility in comparison to common inorganic quantum dots, although the structural features that lead to the biological activities of GQDs are poorly understood. Here we report that coal derived GQDs and their poly(ethylene glycol)-functionalized derivatives serve as efficient antioxidants, and we evaluate their electrochemical, chemical, and in vitro biological activity. Through the evaluation of scavenging abilities toward reactive oxygen species, we demonstrate correlation of π-conjugated stable radicals with activity. Read More

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http://pubs.acs.org/doi/10.1021/acsami.9b01082
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http://dx.doi.org/10.1021/acsami.9b01082DOI Listing
April 2019
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Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats.

J Pharm Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)-induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.

Methods: Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0. Read More

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http://dx.doi.org/10.1111/jphp.13094DOI Listing

Inflammation, Antipsychotic Drugs, and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia.

Curr Top Behav Neurosci 2019 Apr 17. Epub 2019 Apr 17.

School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

In recent years, there is a new optimism in schizophrenia therapeutics with the emergence of immunomodulation as a potential treatment approach. Current evidence points to various immunological abnormalities in schizophrenia, including cell-mediated processes, acute phase proteins, cytokines, and intracellular mediators. Trait- and state-related immune dysfunction appears to exist, and a strong case can therefore be made for immunomodulation therapies in the prevention, treatment, and/or moderating the course of schizophrenia. Read More

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http://dx.doi.org/10.1007/7854_2019_91DOI Listing
April 2019
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Maturation trade-offs in octopus females and their progeny: energy, digestion and defence indicators.

PeerJ 2019 9;7:e6618. Epub 2019 Apr 9.

Laboratorio Nacional de Resiliencia Costera (LANRESC), UNAM-CONACYT, Sisal, Yucatán, Mexico.

Sexual maturation and reproduction influence the status of a number of physiological processes and consequently the ecology and behaviour of cephalopods. Using as a study model, the present work was focused in the changes in biochemical compound and activity that take place during gonadal maturation of females and its consequences in embryo and hatchlings characteristics. To do that, a total of 31 adult females of were sampled to follow metabolites (ovaries and digestive gland) and digestive enzyme activities (alkaline and acidic proteases) during physiological and functional maturation. Read More

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http://dx.doi.org/10.7717/peerj.6618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461028PMC

The Effect of Taxifolin on Cisplatin-Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation.

Mediators Inflamm 2019 12;2019:3740867. Epub 2019 Mar 12.

Department of Nursing, Faculty of Health Sciences, Erzincan Binali Yildirim University, Erzincan, Turkey.

The effect of taxifolin on cisplatin-induced oxidative pulmonary damage was investigated biochemically and histopathologically in male albino Wistar rats. There were four groups, with six animals in each group: 50 mg/kg of taxifolin plus 2.5 mg/kg of cisplatin (TC) group, 2. Read More

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http://dx.doi.org/10.1155/2019/3740867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434269PMC

Inhibition of Advanced Glycation End-Product Formation by High Antioxidant-Leveled Spices Commonly Used in European Cuisine.

Antioxidants (Basel) 2019 Apr 15;8(4). Epub 2019 Apr 15.

Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.

Spices and herbs, as good sources of polyphenols, could be strong inhibitors of advanced glycation end-product (AGE) formation. The aim of this research was to measure the ability of various spices to inhibit AGEs and to study the correlation of AGE inhibition with total phenolic (TP) content and antioxidant capacity. Fourteen spices commonly used in European cuisine were extracted with a 50% ethanol solution, and their water and total phenolic contents and antioxidant capacities were examined. Read More

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http://dx.doi.org/10.3390/antiox8040100DOI Listing

Addition of Sesamol Increases the Oxidative Stability of Beeswax Organogels and Beef Tallow Matrix Under UV Light Irradiation and Thermal Oxidation.

J Food Sci 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Food Science and Biotechnology and Food Flavor Sensory Research Center, Sungkyunkwan Univ., Suwon, Republic of Korea.

To enhance the oxidative stability of organogels made from canola oil, 40 ppm sesamol was added to beeswax-based organogels stored under ultraviolet (UV) light irradiation and 60 or 100 °C thermal oxidation conditions. To study the practical application of organogels as animal fat substitutes, beef tallow was mixed with organogels and their oxidative stability was determined under oxidative stress conditions. Without sesamol addition, the organogels and beef tallow with organogel oxidized rapidly under UV irradiation and thermal oxidation. Read More

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http://dx.doi.org/10.1111/1750-3841.14590DOI Listing
April 2019
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[Protective effects of flavonoids from Gynostemma pentaphyllum on oxidative damage in LLC-PK1 cells].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1193-1200

School of Pharmacy,Minzu University of China Beijing 100081,China.

Four flavonoids were isolated from Gynostemma pentaphyllum by chromatography methods and their structures were identified by MS and NMR spectra data as quercetin-3-O-( 2″,6″-di-α-L-rhamnosyl)-β-D-galactopyranoside( 1),quercetin-3-O-( 2″,6″-di-α-L-rhamnosyl)-β-D-glucopyranoside( 2),quercetin-3-O-( 2″-α-L-rhamnosyl)-β-D-galactopyranoside( 3),and quercetin-3-O-( 2″-α-L-rhamnosyl)-β-D-glucopyranoside( 4). Among them,compounds 1-3 were obtained from the Cucurbitaceae family for the first time.The four flavonoids showed potent antioxidant effects against the DPPH,·OH and ■radicals in vitro,especially for DPPH radical scavenging activity with the IC50 values of 71. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181226.019DOI Listing

Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits.

Environ Sci Pollut Res Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Zoology, University of the Punjab, Lahore, Pakistan.

Cadmium and mercury are non-biodegradable toxic metals that may cause many detrimental effects to the thyroid gland and blood. Vitamin C has been found to be a significant chain-breaking antioxidant and enzyme co-factor against metal toxicity and thus make them less available for animals. The current study was performed to find the effect of individual metals (cadmium and mercury), their co-administration, and the ameliorative effects of vitamin C on some of the parameters that indicate oxidative stress and thyroid dysfunction. Read More

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http://dx.doi.org/10.1007/s11356-019-04886-9DOI Listing
April 2019
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Herbal feed additives containing essential oil: 1. Impact on the nutritional worth of complete feed in vitro.

Trop Anim Health Prod 2019 Apr 15. Epub 2019 Apr 15.

Department of Animal Nutrition, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, 141004, India.

This study was taken up to assess the impact of supplementing herbal feed additives [HFAs; fruit of Myristica fragrans (Jayphall), seeds of Anethum sowa (Suva), fruit of Apium graveolens (Ajmo), fruit of Cuminum cyminum (Jeera), bark of Cinnamonum zeylanicum (Dalchini), or whole plant of Eclipta alba (Bhangro)] containing essential oils as active component on the nutrient utilization and methane production using wheat straw-based total mixed ration (TMR) as a substrate by in vitro gas production technique. The essential oil content was the highest (P < 0.01) in M. Read More

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http://dx.doi.org/10.1007/s11250-019-01887-1DOI Listing

High Dose Pomegranate Extract Suppresses Neutrophil Myeloperoxidase and Induces Oxidative Stress in a Rat Model of Sepsis.

Int J Vitam Nutr Res 2019 Apr 16:1-14. Epub 2019 Apr 16.

6 Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Introduction: The effect of using high dose pomegranate extract on sepsis and its safety is not clarified. Considering the fact that proper immune and inflammatory responses are needed to cope with infection, the aim of current study was to assess the effect of high dose pomegranate extract consumption on oxidative and inflammatory responses after disease induction in rat model of sepsis.

Methods: Sepsis was induced by Cecal Ligation and Perforation (CLP) surgery. Read More

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http://dx.doi.org/10.1024/0300-9831/a000563DOI Listing

Tuning the Transdermal Delivery of Hydroquinone upon Formulation with Novel Permeation Enhancers.

Pharmaceutics 2019 Apr 4;11(4). Epub 2019 Apr 4.

Department of Pharmaceutics and Food Technology, School of Pharmacy, Complutense University of Madrid, Ramón y Cajal square, 28040 Madrid, Spain.

Hydroquinone (HQ) is an anti-hyperpigmentation agent with poor physicochemical stability. HQ formulations are currently elaborated by compounding in local pharmacies. Variability in the characteristics of HQ topical formulations can lead to remarkable differences in terms of their stability, efficacy, and toxicity. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040167DOI Listing
April 2019
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Effects of Extra Virgin Olive Oil and Apples Enriched-Dark Chocolate on Endothelial Progenitor Cells in Patients with Cardiovascular Risk Factors: A Randomized Cross-Over Trial.

Antioxidants (Basel) 2019 Apr 4;8(4). Epub 2019 Apr 4.

Cardiovascular Research Laboratory, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56100 Pisa, Italy.

Background: Endothelial dysfunction has been associated to cardiovascular outcomes in patients with cardiovascular risk factors. Circulating endothelial progenitor cells (EPCs) play an important physiological role for their reparative potential of vascular integrity, but are numerically reduced and functionally impaired in patients with cardiovascular risks. This study assesses the effects of Extra Virgin Olive Oil (EVOO) and apple-enriched dark chocolate intake on the blood levels of EPCs. Read More

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http://dx.doi.org/10.3390/antiox8040088DOI Listing

Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. Read More

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http://dx.doi.org/10.3390/jcm8040453DOI Listing

Luteolin 7-Sulfate Attenuates Melanin Synthesis through Inhibition of CREB- and MITF-Mediated Tyrosinase Expression.

Antioxidants (Basel) 2019 Apr 4;8(4). Epub 2019 Apr 4.

Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea.

Antioxidants with antimelanogenic activity are potentially useful for the attenuation of skin hyperpigmentation disorders. In a previous study, luteolin 7-sulfate isolated from Makino, a marine plant, was shown to inhibit cellular melanin synthesis. The aim of the present study was to examine its action mechanism, focusing on the regulation of tyrosinase (TYR) expression in cells. Read More

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http://dx.doi.org/10.3390/antiox8040087DOI Listing

A Review of Defined Oxidative Balance Scores Relative to Their Components and Impact on Health Outcomes.

Nutrients 2019 Apr 3;11(4). Epub 2019 Apr 3.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

Oxidative Balance Scores (OBSs) are tools that have emerged to evaluate the global balance of individuals' oxidation-reduction status. The aim was to compare OBSs available in the literature regarding their characteristics and associations with chronic diseases in epidemiological studies. Studies that developed OBSs were searched in PubMed until August 2018. Read More

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http://dx.doi.org/10.3390/nu11040774DOI Listing
April 2019
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Antioxidant and Antimicrobial Activity of Rosemary, Pomegranate and Olive Extracts in Fish Patties.

Antioxidants (Basel) 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Food Technology, Nutrition and Food Science, Veterinary Faculty University of Murcia, Campus de Espinardo, 30100 Espinardo, Murcia, Spain.

Natural extracts (rich in bioactive compounds) that can be obtained from the leaves, peels and seeds, such as the studied extracts of Pomegranate (P), Rosemary (RA, Nutrox OS (NOS) and Nutrox OVS (NOVS)), and olive () extracts rich in hydroxytyrosol (HYT-F from olive fruit and HYT-L from olive leaf) can act as antioxidant and antimicrobial agents in food products to replace synthetic additives. The total phenolic compounds, antioxidant capacity (measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-Azinobis (3-ethylbenzothiazolin) -6-sulphonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP), and Oxygen Radical Absorbance Capacity (ORAC)) and their antimicrobial power (using the diffusion disk method with the and strains) were measured. The results showed that all the extracts were good antioxidant and antimicrobial compounds in vitro. Read More

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http://dx.doi.org/10.3390/antiox8040086DOI Listing

Luteolin Shifts Oxaliplatin-Induced Cell Cycle Arrest at G₀/G₁ to Apoptosis in HCT116 Human Colorectal Carcinoma Cells.

Nutrients 2019 Apr 2;11(4). Epub 2019 Apr 2.

School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea.

Certain antioxidative flavonoids are known to activate nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidants and detoxifying response and is reportedly highly activated in many types of cancers. Few studies on the potential undesired effects of flavonoid intake during chemotherapy have been conducted, yet Nrf2 activators could favor cancer cell survival by attenuating chemotherapeutic efficiency. This study aimed to examine if luteolin, an Nrf2 activator, hinders chemotherapeutic activity of oxaliplatin, a potent anticancer agent for colorectal cancer, in HCT116 cells. Read More

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https://www.mdpi.com/2072-6643/11/4/770
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http://dx.doi.org/10.3390/nu11040770DOI Listing
April 2019
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Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases.

Antioxidants (Basel) 2019 Apr 2;8(4). Epub 2019 Apr 2.

Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, No. 1, Jalan Menara Gading, UCSI Heights, Kuala Lumpur 56000, Malaysia.

The risk of macular degeneration can be reduced through the consumption of antioxidant-rich foods, supplements, and nutraceutical formulas. This review focuses on the antioxidants, vitamins, and minerals that have been reported for reducing the risk of macular degeneration and other eye-related diseases. Antioxidants including anthocyanins, carotenoids, flavonoids, and vitamins have been shown to reduce the risk of eye-related diseases. Read More

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https://www.mdpi.com/2076-3921/8/4/85
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http://dx.doi.org/10.3390/antiox8040085DOI Listing
April 2019
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Dandelion is more tolerant to cadmium than to nickel excess.

Chemosphere 2019 Jun 27;224:884-891. Epub 2019 Feb 27.

Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria.

Comparative accumulation of cadmium (Cd) and nickel (Ni) and the consequences for the metabolism of common weed dandelion (triploid ones of Taraxacum sect. Taraxacum) were studied here for the first time. Cd accumulated more in both shoots and roots (489 and 2486 μg/g DW) than Ni (165 and 858 μg/g DW) after 14 days of exposure and only root Ni content did not increase between 7 and 14 days of exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193040
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http://dx.doi.org/10.1016/j.chemosphere.2019.02.181DOI Listing
June 2019
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Binary-ternary Cd(II)-(hydroxycarboxylic acid)-(aromatic chelator) systems exhibit in vitro cytotoxic selectivity in a tissue-specific manner.

J Inorg Biochem 2019 Feb 23;195:201-215. Epub 2019 Feb 23.

Laboratory of Inorganic Chemistry and Advanced Materials, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

Cadmium is a metallotoxin, amply encountered in the environment and derived through physical and anthropogenic activities. Its entry in various organisms leads through water and the food chain to humans, thereby inducing a plethora of pathophysiologies. Delineation of the interactive role of cadmium with physiological and physiologically relevant substrates, requires well-defined forms of cadmium arising from such interactions along with the ensuing chemical reactivity amounting to toxic manifestations and health aberrations. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.009DOI Listing
February 2019
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Ascorbic acid formulation for survivability and diazotrophic efficacy of Azotobacter chroococcum Avi2 (MCC 3432) under hydrogen peroxide stress and its role in plant-growth promotion in rice (Oryza sativa L.).

Plant Physiol Biochem 2019 Apr 6;139:419-427. Epub 2019 Apr 6.

ICAR- National Rice Research Institute, Cuttack, Odisha, 753006, India.

Oxidative stress generates reactive oxygen species which causes cell damage of living organisms and are normally detoxified by antioxidants. Indirect reports signify the damages caused by reactive oxygen species and neutralized by antioxidant, but the direct evidence to confirm this hypothesis is still unclear. To validate our hypothesis, an attempt was made in a diazotrophic bacterium (Azotobacter chroococcum Avi2) as a biological system, and hydrogen peroxide (HO) and ascorbic acid were used as oxidative stress and antioxidant supplement, respectively. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.04.003DOI Listing

Dynamic, shear and pasting behaviour of native and octenyl succinic anhydride (OSA) modified wheat starch and their utilization in preparation of edible films.

Int J Biol Macromol 2019 Apr 13;133:110-116. Epub 2019 Apr 13.

Department of Food Science and Technology, Guru Nanak Dev University, Amritsar, India.

Starch-based edible films could offer non-chemical means for preserving perishable commodities. The present research investigated the effectiveness of native and heat treated Octenyl succinic anhydride (OSA) modified wheat starch in edible film making. Pasting and rheological properties of the native and OSA modified starch as well as antioxidants and sensorial attributes of coated and non-coated grapes were evaluated. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.089DOI Listing

Structural characterization, antioxidant and antibacterial activities of two heteropolysaccharides purified from the bulbs of Lilium davidii var. unicolor Cotton.

Int J Biol Macromol 2019 Apr 12. Epub 2019 Apr 12.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China. Electronic address:

Two heteropolysaccharides, BHP-1 and BHP-2, were separated and purified from the edible bulbs of Lilium davidii var. unicolor Cotton by anion-exchange and gel-permeation chromatography. The primary structural characteristics of BHP-1 and BHP-2 were investigated by Congo red test, X-ray diffractometry (XRD) analysis, IR, GC and NMR. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.082DOI Listing
April 2019
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