488,668 results match your criteria Antioxidants & redox signaling[Journal]


DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis.

Int J Mol Med 2019 Jun 23;43(6):2523-2531. Epub 2019 Apr 23.

A. Gemelli University Polyclinic Foundation, Italy IRCCS, I‑00168 Rome, Italy.

Docosahexaenoic acid (DHA) is an omega‑3 polyunsaturated fatty acid, derived mainly from fish oil. It is well known that DHA is present in high concentrations in nervous tissue and plays an important role in brain development and neuroprotection. However, the molecular mechanisms underlying its role remain to be fully elucidated. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4170DOI Listing

Biochemical changes in cultivars of sweet oranges infected with citrus tristeza virus.

Braz J Biol 2019 Oct-Dec;79(4):742-748. Epub 2019 Apr 18.

Department of Biotechnology, Lahore College for Women University - LCWU, Lahore, Pakistan.

Citrus fruit production occupies a place of considerable importance in the economy of the world including Pakistan. Tristeza disease caused by Citrus Tristeza Virus (CTV) exists in various forms that may or may not cause symptoms in the plants. The bioactive compounds and antioxidants are naturally present in plants and provide a defense mechanism that is generally accelerated in response to a stress. Read More

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http://dx.doi.org/10.1590/1519-6984.193791DOI Listing

Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer's Disease.

Biomed Res Int 2019 20;2019:8983752. Epub 2019 Mar 20.

Department of Science and Technology, Guangdong Medical University, Dongguan 523808, Guangdong, China.

Objective: To observe the effects of resveratrol (Res) on the antioxidative function and estrogen level in an Alzheimer's disease (AD) mouse model.

Methods: First, we examined the effects of Res on an AD mice model. SAMP8 mice were selected as the model, and normal-aging SAMR1 mice were used as the control group. Read More

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http://dx.doi.org/10.1155/2019/8983752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446083PMC

Microencapsulation of Moringa oleifera leaf extracts with vegetable protein as wall materials.

Food Sci Technol Int 2019 Apr 23:1082013219842469. Epub 2019 Apr 23.

1 Department of Food Science and Nutrition, Faculty of Science and Technology, Prince of Songkla University, Mueang, Thailand.

Moringa oleifera, often referred to as 'miracle tree' contains high amount of bioactive nutrients and dietary antioxidants, which help in ameliorating oxidative stress and degenerating diseases. However, the bioactive compounds are highly susceptible to degradation, and this may decrease the antioxidants activity present in M. oleifera. Read More

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http://dx.doi.org/10.1177/1082013219842469DOI Listing

The Long-Term Algae Extract () and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations.

Antioxidants (Basel) 2019 Apr 16;8(4). Epub 2019 Apr 16.

Clínica CIROM, Centro de Implantología and Rehabilitación Oral Multidisciplinaria, 30001 Murcia, Spain.

The toxicity of heavy metals such as Hg is a serious risk for human health. We evaluated whether 90 days of nutritional supplementation (d90, = 16) with (CV) and extracts in conjunction with aminosulphurate (nutraceuticals) supplementation could detox heavy metal levels in patients with long-term titanium dental implants (average: three, average: 12 years in mouth) and/or amalgam fillings (average: four, average: 15 years) compared to baseline levels (d0: before any supplementation, = 16) and untreated controls (without dental materials) of similar age (control, = 21). In this study, we compared levels of several heavy metals/oligoelements in these patients after 90 days ( = 16) of nutritional supplementation with CV and aminozuphrates extract with their own baseline levels (d0, = 16) and untreated controls ( = 21); 16 patients averaging 44 age years old with long-term dental amalgams and titanium implants for at least 10 years (average: 12 years) were recruited, as well as 21 non-supplemented controls (without dental materials) of similar age. Read More

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http://dx.doi.org/10.3390/antiox8040101DOI Listing

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo.

Antioxidants (Basel) 2019 Apr 12;8(4). Epub 2019 Apr 12.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Resveratrol (RSV) is a polyphenolic phytoalexin found in peanuts, grapes, and other plants. Uterine fibroids (UF) are benign growths that are enriched in extracellular matrix (ECM) proteins. In this study, we aimed to investigate the effects of RSV on UF using in vivo and in vitro approaches. Read More

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http://dx.doi.org/10.3390/antiox8040099DOI Listing

Investigation of In-Vitro Antioxidant and Electrochemical Activities of Isolated Compounds from P.J.Bergius Extract.

Antioxidants (Basel) 2019 Apr 12;8(4). Epub 2019 Apr 12.

Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.

We have investigated the in-vitro antioxidant activity and electrochemical redox properties of a number of natural compounds (carnosol, carnosic acid, 7-ethoxyrosmanol, ursolic acid, rosmanol and ladanein) isolated from the methanolic extract of collected from the Cape floristic region, South Africa. The results from trolox equivalent antioxidant capacity (TEAC), ferric-ion reducing antioxidant parameter (FRAP) oxygen radical absorbance capacity (ORAC), as well as the inhibition of Fe-induced lipid peroxidation showed strong antioxidant capacities for carnosol and rosmanol. A structural analysis of the compounds suggests that multiple OH substitution, conjugation and lactone ring in carnosol and rosmanol are important determinants of the free radical scavenging activity and electrochemical behavior. Read More

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http://dx.doi.org/10.3390/antiox8040098DOI Listing

Curcumin: New Insights into an Ancient Ingredient against Cancer.

Int J Mol Sci 2019 Apr 12;20(8). Epub 2019 Apr 12.

Department of Internal Medicine V: Hematology and Oncology, Medical University of Innsbruck, Innsbruck 6020, Austria.

Cancer patients frequently use complementary medicine. Curcumin (CUR) and its derivates (from the extract of L.) represent some of the most frequently used ones, having a long history in traditional Asian medicine. Read More

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http://dx.doi.org/10.3390/ijms20081808DOI Listing

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases.

Molecules 2019 Apr 22;24(8). Epub 2019 Apr 22.

Nucleic Acids Research Lab, Department of Chemistry, University of Delhi (North Campus), Delhi 110007, India.

Oxidative stress is proposed as a regulatory element in ageing and various neurological disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce an oxidation-reduction imbalance in organisms. Paucity of the antioxidant system generates oxidative-stress, characterized by elevated levels of reactive species (oxygen, hydroxyl free radical, and so on). Read More

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http://dx.doi.org/10.3390/molecules24081583DOI Listing

Subcritical Fluid Extraction of Antioxidant Phenolic Compounds from Pistachio (Pistacia vera L.) Nuts: Experiments, Modeling, and Optimization.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Facultad de Ciencias Exactas, Físicas y Naturales (UNC), Inst. Multidisciplinario de Biología Vegetal (IMBIV), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Univ. Nacional de Córdoba (UNC), Av. Vélez Sarsfield 1611, Córdoba, Argentina.

A process to obtain phenolic compounds with antioxidant properties from pistachio nuts using water/ethanol mixture under high temperature and pressure conditions was carried out. To optimize extraction conditions and antioxidant activity of bioactive compounds, theoretical models were scanned against experimental data. Phenolic profile was dominated by several flavonoids and gallic acid derivatives. Read More

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http://dx.doi.org/10.1111/1750-3841.14507DOI Listing

Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Dept. of Nutrition, School of Public Health, Sun Yat-Sen Univ., No.74, 2nd Yat-Sen Road, Guangzhou, Guangdong, 510080, China.

We aim to study the antioxidative and anti-inflammatory effects of lycopene on type 2 diabetes mellitus (T2DM) rats, anticipating a complementary strategy for the prevention of long-term complications of T2DM. In this study, rats with streptozotocin-induced diabetes were divided into four groups, receiving a 10-week lycopene intervention: DM, DM + low dose of lycopene (L), DM + medium dose of lycopene (M), and DM + high dose of lycopene (H) group with 0, 5, 10, and 15 mg/kg BW lycopene, respectively. At the end of intervention, fasted blood glucose (FBG) level, oxidative stress indicators, including glycosylated hemoglobin (GHb), glycosylated low-density lipoprotein, oxidized low-density lipoprotein (ox-LDL). Read More

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http://dx.doi.org/10.1111/1750-3841.14505DOI Listing

Impact of red versus white meat consumption in a prudent or Western dietary pattern on the oxidative status in a pig model.

J Agric Food Chem 2019 Apr 23. Epub 2019 Apr 23.

Human diets contain a complex mixture of antioxidants and pro-oxidants that contribute to the body's oxidative status. In this study, 32 pigs were fed chicken versus red & processed meat in the context of a prudent or Western dietary pattern for four weeks, to investigate their oxidative status. Lipid oxidation products (malondialdehyde, 4-hydroxy-2-nonenal and hexanal) were higher in the chicken versus red & processed meat diets (1. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00559DOI Listing

Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.

Cochrane Database Syst Rev 2019 Apr 23;4:CD013315. Epub 2019 Apr 23.

Department of Critical Care, Fundacion Universitaria de Ciencias de la Salud, Hospital de San José, Carrera 19 # 8-32, Bogota, Bogota, Colombia, 11001.

Background: High altitude illness (HAI) is a term used to describe a group of mainly cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (˜ 8200 feet). Acute mountain sickness (AMS), high altitude cerebral oedema (HACE), and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude ascent. In this, the third of a series of three reviews about preventive strategies for HAI, we assessed the effectiveness of miscellaneous and non-pharmacological interventions. Read More

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http://dx.doi.org/10.1002/14651858.CD013315DOI Listing

Antioxidant properties and structured biodiversity in a diverse set of wild cranberry clones.

Heliyon 2019 Apr 11;5(4):e01493. Epub 2019 Apr 11.

Department of Biology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.

Wild germplasm with elevated antioxidants are a useful resource for using directly and in a breeding program. In a study with 136 wild clones and two cranberry cultivars, phenolic, flavonoid and anthocyanin contents varied 2.79, 2. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465588PMC

Pharmacokinetic evaluation, molecular docking and in vitro biological evaluation of 1, 3, 4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors.

J Pharm Anal 2019 Apr 7;9(2):133-141. Epub 2018 Dec 7.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India.

1, 3, 4-Oxadiazole derivatives were previously synthesized to investigate their anticancer properties. However, studies relating to their antioxidant potential and signal transducer and activator of transcription (STAT) inhibition have not been performed. We investigated previously synthesized 1, 3, 4-oxadiazole derivatives ( for various radical scavenging properties using several in vitro antioxidant assays and also for direct inhibition of STAT3 through molecular docking. Read More

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http://dx.doi.org/10.1016/j.jpha.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460303PMC

Evaluation of the therapeutic potential effect of Fas receptor gene Knockdown in experimental model of Non-Alcoholic Steatohepatitis.

Free Radic Res 2019 Apr 23:1-241. Epub 2019 Apr 23.

c Persian Gulf's Physiology Research Center (PRC) , Alimentary Tract Research Center , Department of Physiology , School of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Aim: Stimulation of Fas death receptor is introduced as a major cause of nonalcoholic steatohepatitis (NASH) progression through suppression of cell viability. Therefore, the blocking of death pathways is hypothesized to be express new approaches to NASH therapy. For this purpose, current experiment applied synthetic small interference RNA (SiRNA) to trigger Fas death receptor and to show its potential therapeutic role in designed NASH model. Read More

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http://dx.doi.org/10.1080/10715762.2019.1608982DOI Listing

A review on proteomics analysis to reveal biological pathways and predictive proteins in sulfur mustard exposed patients: roles of inflammation and oxidative stress.

Inhal Toxicol 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Chemical Injuries Research Center , Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences , Tehran , Iran.

Sulfur mustard (SM) is a mutagenic compound that targets various organs. Although it causes a wide range of abnormalities, cellular and molecular mechanisms of its action are not-well-understood. Oxidation of DNA, proteins, lipids, as well as depletion of cellular nicotinamide adenine dinucleotide (NAD), antioxidants and increase of intracellular calcium are the hypothesized mechanisms of its action at the acute phase of injury. Read More

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http://dx.doi.org/10.1080/08958378.2018.1558316DOI Listing

Antioxidants Special Issue: Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family.

Authors:
Aron B Fisher

Antioxidants (Basel) 2019 Apr 19;8(4). Epub 2019 Apr 19.

Department of Physiology and the Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

The peroxiredoxins, first discovered about 30 years ago, are the most recently described family of ubiquitously expressed antioxidant enzymes [... Read More

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http://dx.doi.org/10.3390/antiox8040107DOI Listing

The Application of Selenium and Copper Nanoparticles Modifies the Biochemical Responses of Tomato Plants under Stress by .

Int J Mol Sci 2019 Apr 20;20(8). Epub 2019 Apr 20.

Departamento de Botánica, Universidad Autónoma Agraria Antonio Narro, Saltillo COA 25315, Mexico.

Early blight is a disease that greatly affects Solanaceae, mainly damaging tomato plants, and causing significant economic losses. Although there are methods of biological control, these are very expensive and often their mode of action is slow. Due to this, there is a need to use new techniques that allow a more efficient control of pathogens. Read More

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http://dx.doi.org/10.3390/ijms20081950DOI Listing

Flavonoid Analysis and Antioxidant Activities of the L. Aerial Parts.

Antioxidants (Basel) 2019 Apr 20;8(4). Epub 2019 Apr 20.

Department of Pharmaceutical Botany, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, 400337 Romania.

L. is the only species found in Romanian flora, being known as a remedy for inflammatory pathologies or for its hepatoprotective and adaptogen activities. The present investigation studied the flavonoid composition and antioxidant activities of the aerial parts of this species. Read More

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http://dx.doi.org/10.3390/antiox8040108DOI Listing

Combination of Carvacrol and Thymol: Antimicrobial Activity Against and Antioxidant Activity.

Foodborne Pathog Dis 2019 Apr 19. Epub 2019 Apr 19.

2 Department of Food Hygiene and Technology, University of León, Campus de Vegazana, León, Spain.

Plant and essential oil extracts have been used for some time as antimicrobials and antioxidants, although little is known about the interactions between the main components of these plant materials. This knowledge could help to design more potent antimicrobial and antioxidant mixtures. Carvacrol and thymol, the main components of the essential oils of the Lamiaceae family of plants, were assessed in combination to evaluate their antioxidant activity and antimicrobial effect against 19 strains of () of different origins (clinical, meat, milk, and other) and mostly (12) enterotoxin producers. Read More

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http://dx.doi.org/10.1089/fpd.2018.2594DOI Listing

A Histologic Perspective on Electrical and Thermal Burn-Injured Human Skin.

Adv Skin Wound Care 2019 May;32(5):1-7

At the University of Bielsko-Biala, Poland, Anna Pielesz, PhD, is Professor, Faculty of Materials, Civil and Environmental Engineering; Andrzej Gawłowski, PhD, is Professor, Faculty of Materials, Civil and Environmental Engineering; Dorota Biniaś, PhD, is Professor, Faculty of Materials, Civil and Environmental Engineering; Rafał Bobiński, PhD, is Dean, Faculty of Health Sciences; Marek Kawecki, Prof Dr, is Professor, Faculty of Health Sciences; Ewa Sama, PhD, is Professor, Faculty of Materials, Civil and Environmental Engineering; and Wioletta Waksmańska, PhD, is Vice Dean, Faculty of Health Sciences.

Objective: To analyze specific spectroscopic (FT-Raman) and thermal (limiting oxygen index) aspects of skin samples exposed to electrical injury compared with thermal injury.

Methods: An observational case-control study was conducted at the Dr Stanislaw Sakiel Center for Burns Treatment in Siemianowice, Silesia, Poland. A scanning electron microscope was used to diagnose and illustrate the topography of skin samples from electrical and thermal burns and the morphologic effects on damaged versus undamaged skin surfaces. Read More

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http://dx.doi.org/10.1097/01.ASW.0000554446.59743.9fDOI Listing

Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract.

J Am Coll Nutr 2019 Apr 22:1-11. Epub 2019 Apr 22.

b TPM Bioactives Division , The Product Makers Pty Ltd , Melbourne , Australia.

Objectives: Dysfunctional metabolism of carbohydrates is a fundamental component of many dietary-related disorders. It has been hypothesized that plant extracts containing high levels of antioxidants may have the ability to stabilize carbohydrate regulation. The aim of this study was to assess the effects of a polyphenol-rich sugarcane extract on cellular pathways related to carbohydrate metabolism. Read More

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http://dx.doi.org/10.1080/07315724.2019.1587323DOI Listing

Influence of Mineral Supplementation on the Results from Analysis of Flavonol Glycoside Content in Dietary Supplements.

Prev Nutr Food Sci 2019 Mar 6;24(1):75-83. Epub 2018 Nov 6.

Department of Food Science and Biotechnology, Chungbuk National University, Chungbuk 28644, Korea.

Flavonoids are a major component of extract (GBE). Several studies have investigated chelate formation and the redox reaction between flavonoids and metal ions; however, the effect of mineral supplements on the results from the analysis of the flavonol glycoside content in products containing GBE dietary supplement remains unknown. In this study, the effects of commonly used mineral supplements on the recovery of quercetin from GBE-containing dietary supplements were investigated using conventional methods of flavonol glycoside determination. Read More

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http://dx.doi.org/10.3746/pnf.2019.24.1.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456232PMC
March 2019
2 Reads

Biological Significance of Glutathione S-Transferases in Human Sperm Cells.

J Hum Reprod Sci 2019 Jan-Mar;12(1):24-28

Department of Medical Biology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Background: Oxidative stress is considered as one of the causes of male subfertility or infertility. Among antioxidant enzymes, the crucial role belongs to glutathione -transferases (GSTs). Data on the biological role of GSTs in the defense mechanisms of sperm cells in fertile and infertile men are limited. Read More

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http://dx.doi.org/10.4103/jhrs.JHRS_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472203PMC

Role of Oxidative Stress in Male Infertility: An Updated Review.

Authors:
Ahmed T Alahmar

J Hum Reprod Sci 2019 Jan-Mar;12(1):4-18

Department of Pathological Analysis, College of Science, University of Sumer, Thi-Qar, Iraq.

Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm DNA damage and increased risk of recurrent abortions and genetic diseases. A review of PubMed, Medline, Google Scholar, and Cochrane review databases of published articles from years 2000-2018 was performed focusing on physiological and pathological consequences of reactive oxygen species (ROS), sperm DNA damage, OS tests, and the association between OS and male infertility, pregnancy and assisted reproductive techniques outcomes. Generation of ROS is essential for reproductive function, but OS is detrimental to fertility, pregnancy, and genetic status of the newborns. Read More

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http://www.jhrsonline.org/text.asp?2019/12/1/4/255779
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http://dx.doi.org/10.4103/jhrs.JHRS_150_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472207PMC
April 2019
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Antioxidant activity and the isolation of polyphenols and new iridoids from Chilean Gaultheria phillyreifolia and G. poeppigii berries.

Food Chem 2019 Sep 5;291:167-179. Epub 2019 Apr 5.

Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile. Electronic address:

The berries from the native Chilean Gaultheria phillyreifolia and G. poeppigii are appreciated for their sweet taste and aroma. Fruits from both species were investigated for their secondary metabolite composition and antioxidant activity. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.04.019DOI Listing
September 2019

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: An in vitro study.

Toxicol Ind Health 2019 Apr 21:748233719842499. Epub 2019 Apr 21.

1 Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, Karnataka, India.

The present study was undertaken to investigate the toxic effect of ground water fluoride (F) on motility, abnormality, and antioxidant status of spermatozoa. Treatment of ground water F with epididymal sperm suspension caused complete loss of sperm motility and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) and increase in the concentration of malondialdehyde (MDA) and abnormality of spermatozoa at 15 and 30 min time intervals. Further, incubation of spermatozoa with ground water F for 5, 10, and 15 min time intervals significantly reduced the sperm motility and activities of SOD and CAT and increased the concentration of MDA and abnormality of spermatozoa. Read More

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http://dx.doi.org/10.1177/0748233719842499DOI Listing

Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

Zoology Department, Faculty of Science, Ain Shams University, Khalifa El-Maamon St, Abbasiya Sq, Cairo, 11566, Egypt.

Nowadays, medicinal plants have been widely used everywhere to provide essential care for many disorders including diabetes. Recent reports assumed that the antidiabetic activities of pomegranate aril juice (PAJ) may be ascribed to its punicalagin (PCG). Therefore, the present study evaluated and compared the antidiabetic activities of PAJ and its PCG, and monitored some mechanisms of their actions in streptozotocin-nicotinamide (STZ-NA) type 2 diabetic rats. Read More

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http://dx.doi.org/10.1007/s11033-019-04813-8DOI Listing
April 2019
1 Read

Diabetic retinopathy, a vascular and inflammatory disease: therapeutic implications.

Diabetes Metab 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, Italy. Electronic address:

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and the leading cause of visual impairment in the working-age population in the Western world. Diabetic macular oedema (DME) is one of the major complications of DR. Therapy with intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs has become the gold standard treatment for DR and its complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12623636193006
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http://dx.doi.org/10.1016/j.diabet.2019.04.002DOI Listing
April 2019
1 Read

Superoxide dismutase in nanoarchaeosomes for targeted delivery to inflammatory macrophages.

Colloids Surf B Biointerfaces 2019 Mar 28;179:479-487. Epub 2019 Mar 28.

Nanomedicine Research & Development Center, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Bernal, B1876BXD, Argentina. Electronic address:

Oxidative stress plays an essential role in the pathogenesis and progression of inflammatory bowel disease. Co-administration of antioxidants and anti-inflammatory drugs has shown clinical benefits. Due to its significant reactive oxygen species (ROS) scavenging ability, great interest has been focused on superoxide dismutase (SOD) for therapeutic use. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193021
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http://dx.doi.org/10.1016/j.colsurfb.2019.03.061DOI Listing
March 2019
2 Reads

Prediction of Antioxidant proteins by incorporating statistical moments based features into Chou's PseAAC.

J Theor Biol 2019 Apr 18. Epub 2019 Apr 18.

Department of Computer Science, School of Systems and Technology, University of Management and Technology, Lahore, Pakistan.

Antioxidant proteins are considered crucial in the areas of research on life sciences and pharmacology. They prevent damage to cells and DNA which are caused by free radicals. The role of antioxidants in the ageing process makes them more significant in their accurate identification. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.019DOI Listing

Oxidative stress: One potential factor for arsenite-induced increase of N-methyladenosine in human keratinocytes.

Environ Toxicol Pharmacol 2019 Apr 13;69:95-103. Epub 2019 Apr 13.

Department of Environmental and Occupational Health, West China School of Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address:

N-methyladenosine (mA) modification is affected by oxidative stress and gets involved in arsenite toxicity. However, whether oxidative stress is one factor in arsenite-induced alteration of mA levels remains unclear. Here, reactive oxygen species (ROS), product of lipid peroxidation (MDA), antioxidants (GSH and SOD), mA levels, mA methyltransferases (METTL3, METTL14, and WTAP) and demethylases (FTO and ALKBH5) were detected in human keratinocytes exposed to different concentrations of arsenite. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13826689193004
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http://dx.doi.org/10.1016/j.etap.2019.04.005DOI Listing
April 2019
1 Read

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Antioxidants (Basel) 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g. Read More

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http://dx.doi.org/10.3390/antiox8040106DOI Listing

Phytochemical Characterization of Five Edible Purple-Reddish Vegetables: Anthocyanins, Flavonoids, and Phenolic Acid Derivatives.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 Calea Manastur, Cluj-Napoca 400372, Romania.

Vegetables comprise a significant portion of our daily diet with their high content in nutrients including fiber, vitamins, minerals, as well as phenolic compounds. Vegetable consumption has been shown to be positively associated with the prevention of several degenerative diseases thanks to their bioactive compounds. Accordingly, five selected vegetables, namely, red chicory, red onion, eggplant, purple sweet potato, and black carrot were thoroughly assessed for their phenolic content in this study. Read More

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http://dx.doi.org/10.3390/molecules24081536DOI Listing

Putative Effects of Nutritive Polyphenols on Bone Metabolism In Vivo-Evidence from Human Studies.

Nutrients 2019 Apr 18;11(4). Epub 2019 Apr 18.

Department of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, 53115 Bonn, Germany.

For the prevention and treatment of bone loss related diseases, focus has been put on naturally derived substances such as polyphenols. Based on human intervention studies, this review gives an overview of the effects of dietary significant polyphenols (flavonoids, hydroxycinnamic acids, and stilbenes) on bone turnover. Literature research was conducted using PubMed database and articles published between 01/01/2008 and 31/12/2018 were included (last entry: 19/02/2019). Read More

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http://dx.doi.org/10.3390/nu11040871DOI Listing

Induction of endoplasmic reticulum stress might be responsible for defective autophagy in cadmium-induced prostate carcinogenesis.

Toxicol Appl Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology, Louisville, KY, USA. Electronic address:

Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The present study suggests that chronic Cd exposure induces endoplasmic reticulum (ER) stress that triggers the phosphorylation of stress transducers [protein kinase R-like ER Kinase- (PERK), eukaryotic translation initiation factor 2-alpha- (eIF2-α) and Activating Transcription Factor 4 -(ATF-4)], resulting in defective autophagy that protects Cd-exposed RWPE-1 cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X193013
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http://dx.doi.org/10.1016/j.taap.2019.04.012DOI Listing
April 2019
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Optimization of Cultivation Conditions of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) for the Highest Antioxidant Activity and Antioxidant Content.

Int J Med Mushrooms 2019 ;21(4):353-366

Institute of Food Biotechnology and College of Food Science, South China Agricultural University, Guangzhou, Guangdong, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou, Guangdong, China.

Ganoderma lucidum is a famous medicinal mushroom that is rich in antioxidants. The content of antioxidant components of grains can be effectively improved by G. lucidum as the fermenting strain. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030338DOI Listing
January 2019
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Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study.

J Korean Med Sci 2019 Apr 22;34(15):e117. Epub 2019 Apr 22.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Removal of uremic toxins such as indoxyl sulfate by AST-120 is known to improve renal function and delay the initiation of dialysis in patients with advanced chronic kidney disease. However, it is unclear whether the addition of AST-120 to conventional treatments is effective in delaying the progression of renal dysfunction in patients with diabetic nephropathy.

Methods: A total of 100 patients with type 2 diabetes and renal dysfunction (serum creatinine levels ranging from 1. Read More

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https://jkms.org/DOIx.php?id=10.3346/jkms.2019.34.e117
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http://dx.doi.org/10.3346/jkms.2019.34.e117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473095PMC
April 2019
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Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu.

ACS Omega 2019 Mar 15;4(3):5356-5366. Epub 2019 Mar 15.

Department of Physical and Environmental Science, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario M1C 1A4, Canada.

Understanding the factors that give rise to tau aggregation and reactive oxygen species (ROS) is the key aspect in Alzheimer's disease pathogenesis. Microtubule (MT) binding repeats of tau protein were suggested to play a critical role in tau aggregation. Here, we show that the interaction of Cu with full-length MT binding repeats R1-R4 leads to the aggregation, and a Cys-based redox chemistry is critically involved in tau aggregation leading to disulfide-bridge dimerization of R2 and R3 and further aggregation into a fibrillar structure. Read More

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http://pubs.acs.org/doi/10.1021/acsomega.8b03595
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http://dx.doi.org/10.1021/acsomega.8b03595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463671PMC
March 2019
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Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance.

Proc Natl Acad Sci U S A 2019 Apr 18. Epub 2019 Apr 18.

Department of Molecular Oncology, BC Cancer, Vancouver V5Z 1L3, Canada;

The family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic RAS transformation are well documented, including constitutive signaling through the RAF-MEK-ERK proproliferative pathway as well as the PI3K-AKT prosurvival pathway. Notably, control of redox balance has also been proposed to contribute to RAS transformation. Read More

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http://dx.doi.org/10.1073/pnas.1821323116DOI Listing
April 2019
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Clinical utility of genomic analysis in adults with idiopathic liver disease.

J Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

Background & Aims: Adult patients suffering from liver disease of unknown cause represent an understudied and underserved population. The use of whole-exome sequencing (WES) for the assessment of a broader spectrum of non-oncological diseases, among adults, remains poorly studied. We assessed the utility of WES in the diagnosis and management of adults with unexplained liver disease despite comprehensive evaluation by a hepatologist and with no history of alcohol overuse. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193011
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http://dx.doi.org/10.1016/j.jhep.2019.01.036DOI Listing
April 2019
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Combined effect of natural antioxidants and antimicrobial compounds during refrigerated storage of nitrite-free frankfurter-type sausage.

Food Res Int 2019 Jun 27;120:839-850. Epub 2018 Nov 27.

Centro Tecnológico de la Carne de Galicia, Parque Tecnológico de Galicia, rúa Galicia n° 4, San Cibrao das Viñas, Ourense 32900, Spain. Electronic address:

The effects of nisin (200 and 400 ppm), ε-polylysine (0.1 and 0.2%) and chitosan (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09639969183093
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http://dx.doi.org/10.1016/j.foodres.2018.11.048DOI Listing
June 2019
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Chemistry, pharmacology and new trends in traditional functional and medicinal beverages.

Food Res Int 2019 Jun 3;120:478-503. Epub 2018 Nov 3.

Programa de Pós-graduação em Engenharia Química, Universidade de Uberaba-UNIUBE, Campus Aeroporto, Av. Nenê Sabino 1802, CEP 38055-500 Uberaba, MG, Brazil. Electronic address:

Functional and medicinal beverages consumption plays an important role in human health, considering that metabolites, with a wide range of pharmacological effects, are inserted in the human diet. Nowadays, the most consumed beverages are obtained from Camellia sinensis leaves and coffee grain processing, and contain different classes of polyphenols and phenolic acids in their phytochemical composition. Besides C. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.10.091DOI Listing

Japanese, Mediterranean and Argentinean diets and their potential roles in neurodegenerative diseases.

Food Res Int 2019 Jun 10;120:464-477. Epub 2018 Nov 10.

Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, Burjassot, València, Spain. Electronic address:

Environmental factors are responsible of cellular senescence and processes found in the development of cognitive disorders. The aim of this paper is to compare benefits of the Japanese, Mediterranean, and Argentinian Diet on the onset or prevention of senile dementia (SD) and Alzheimer's Disease (AD). Special focus was on the effects of specific compounds such as polyunsaturated fatty acids (PUFAs), antioxidants, and saturated and trans fatty acids. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09639969183088
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http://dx.doi.org/10.1016/j.foodres.2018.10.090DOI Listing
June 2019
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Protective effect of hydroxytyrosol and rosemary extract in a comparative study of the oxidative stability of Echium oil.

Food Chem 2019 Aug 27;290:316-323. Epub 2019 Mar 27.

Department of Production and Characterization of Novel Foods, Institute of Food Science Research (CIAL, CSIC-UAM), C/ Nicolas Cabrera 9, 28049 Madrid, Spain. Electronic address:

The oxidative stability of Echium oil has been studied by two accelerated oxidation methodologies namely Rancimat and differential scanning calorimetry at selected temperatures in the range 50-110 °C. Kinetic analyses have provided Arrhenius parameters, oxidative stability indexes (OSI), temperature coefficients (t), Q and OSI at 20 °C (OSI) for both methodologies focussing on secondary and tertiary oxidation products. Peroxide, p-anisidine and polar compounds values have been measured to characterize from primary to tertiary oxidation products. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.03.141DOI Listing

Polyphenols, from Antioxidants to Anti-Inflammatory Molecules: Exploring a Network Involving Cytochromes P450 and Vitamin D.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.

Inflammatory response represents one of the main mechanisms of healing and tissue function restoration. On the other hand, chronic inflammation leads to excessive secretion of pro-inflammatory cytokines involved in the onset of several diseases. Oxidative stress condition may contribute in worsening inflammatory state fall, increasing reactive oxygen species (ROS) production and cytokines release. Read More

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https://www.mdpi.com/1420-3049/24/8/1515
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http://dx.doi.org/10.3390/molecules24081515DOI Listing
April 2019
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Comparative Transcriptomic Studies on a Cadmium Hyperaccumulator and Its Non-Tolerant Counterpart .

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

Many plants growing in mining areas exhibit high levels of cadmium (Cd) tolerance and accumulation, and thus are ideal organisms for comparative studies on molecular mechanisms of Cd hyperaccumulation. However, transcriptomic studies of hyperaccumulative plants in Violaceae are rare. is an amazing Cd hyperaccumulator in metalliferous areas of China, whereas its relative is a non-tolerant accumulator that resides at non-metalliferous sites. Read More

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http://dx.doi.org/10.3390/ijms20081906DOI Listing
April 2019
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On the Origin and Fate of Reactive Oxygen Species in Plant Cell Compartments.

Antioxidants (Basel) 2019 Apr 17;8(4). Epub 2019 Apr 17.

Department of Biochemistry, Palacký University in Olomouc, Šlechtitelů 27,CZ-78371 Olomouc, Czech Republic.

Reactive oxygen species (ROS) have been recognized as important signaling compoundsof major importance in a number of developmental and physiological processes in plants. Theexistence of cellular compartments enables efficient redox compartmentalization and ensuresproper functioning of ROS-dependent signaling pathways. Similar to other organisms, theproduction of individual ROS in plant cells is highly localized and regulated bycompartment-specific enzyme pathways on transcriptional and post-translational level. Read More

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https://www.mdpi.com/2076-3921/8/4/105
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http://dx.doi.org/10.3390/antiox8040105DOI Listing
April 2019
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Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies?

Antioxidants (Basel) 2019 Apr 17;8(4). Epub 2019 Apr 17.

Universitat Jaume I, Unitat predepartamental de Medicina, Avda/Sos Baynat, S/N, 12071 Castellón de la Plana, Spain.

Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on anti-vascular endothelial growth factor (VEGF) strategies, antioxidants or anti-inflammatory therapies are only partially effective or show some adverse side effects. Abscisic acid (ABA) is a phytohormone present in vegetables and fruits that can be naturally supplied by the dietary intake and has been previously studied for its benefits to human health. Read More

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https://www.mdpi.com/2076-3921/8/4/104
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http://dx.doi.org/10.3390/antiox8040104DOI Listing
April 2019
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