480,316 results match your criteria Antioxidants & redox signaling[Journal]


Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells.

In Vitro Cell Dev Biol Anim 2018 Dec 13. Epub 2018 Dec 13.

Department of Biophysics, Yeditepe University School of Medicine, Yeditepe University, Istanbul, Turkey.

There has been a controversy in the oncology field about the use of antioxidants along with chemotherapeutics in cancer treatment. This study aimed to investigate the effects of a potent antioxidant (astaxanthin) co-treatment with a promising anti-cancer drug (carbendazim), which is in phase I clinical trials, on MCF-7 breast cancer cell proliferation. MCF-7 cells were treated with carbendazim, astaxanthin, or their combinations and incubated for 24 h. Read More

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December 2018

Polyphenol-associated oxidative stress and inflammation in a model of LPS-induced inflammation in glial cells: do we know enough for responsible compounding?

Inflammopharmacology 2018 Dec 13. Epub 2018 Dec 13.

Department Physiological Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Cyanidin and chlorogenic acid are polyphenols from plant origin that are present in many common fruits, particularly in berries. To corroborate the protective or detrimental effects of both compounds from a neuro-inflammatory perspective, in vitro experiments were carried out in human astrocytes (U-373). Astrocytes were pre-treated with a range of concentrations of either cyanidin, chlorogenic acid or a combined treatment for a period of 30 min, before exposure to Escherichia coli lipopolysaccharide (LPS) challenge for 23. Read More

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December 2018

Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia.

Taiwan J Obstet Gynecol 2018 Dec;57(6):779-790

Department of Medical Biotechnology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Preeclampsia is a hypertensive disorder in pregnant women, which can be the leading cause of maternal and neonatal death or premature birth. Although the cause of preeclampsia is still not clear, local or systemic oxidative stress may explain the pathological features associated with this complication. However, it is not clear whether oxidative stress is the cause or the result of preeclampsia. Read More

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December 2018

Evaluation of Pseudomonas graminis CPA-7 as a biopreservation method for fresh-cut pear: Physicochemical, enzymatic, and nutritional quality.

Food Sci Technol Int 2018 Dec 13:1082013218816483. Epub 2018 Dec 13.

1 Institute of Agrifood Research and Technology, XaRTA-Postharvest, Lleida, Spain.

Biological preservation methods with bacterial antagonists have emerged as alternatives to chemical sanitizers for extending shelf-life and reducing the population of pathogenic microorganisms. In addition, calcium plays an important role in maintaining the quality of fruit, and postharvest calcium treatments might determine the potential of fruit for processing. The objective of this work was to evaluate the effect of the postharvest application of calcium and biopreservation with the CPA-7 strain of Pseudomonas graminis on the quality parameters of fresh-cut pears. Read More

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December 2018

The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function.

Antioxidants (Basel) 2018 Dec 12;7(12). Epub 2018 Dec 12.

Sorbonne Université, CNRS, INSERM, Institut de Biologie Paris-Seine, Biological Adaptation and Ageing, B2A-IBPS, F-75005 Paris, France.

Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated enzymatic repair systems. Oxidation of cysteine first results in either the formation of a disulfide bridge or a sulfenic acid. Read More

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December 2018

New Insights into the Potential of Endogenous Redox Systems in Wheat Bread Dough.

Antioxidants (Basel) 2018 Dec 12;7(12). Epub 2018 Dec 12.

Enzyme and Protein Chemistry (EPC), Department of Systems Biology, Technical University of Denmark, Building 224, DK-2800 Kgs Lyngby, Denmark.

Various redox compounds are known to influence the structure of the gluten network in bread dough, and hence its strength. The cereal thioredoxin system (NTS), composed of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent thioredoxin reductase (NTR) and thioredoxin (Trx), is a major reducing enzymatic system that is involved in seed formation and germination. NTS is a particularly interesting tool for food processing due to its heat stability and its broad range of protein substrates. Read More

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December 2018

Far Infrared Irradiation Enhances Nutraceutical Compounds and Antioxidant Properties in Angelica gigas Nakai Powder.

Antioxidants (Basel) 2018 Dec 11;7(12). Epub 2018 Dec 11.

College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.

The aim of this study was to investigate the effect of far infrared irradiation (FIR) on nutraceutical compounds, viz. total phenolic content, total flavonoids, and antioxidant capacity, of Nakai (AGN). The FIR treatment was applied for 30 min with varied temperatures of 120, 140, 160, 180, 200, 220, and 240 °C. Read More

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December 2018

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, UK.

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Huntington's disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase over the next decades due to increasing life expectancies. No cure is currently available for the treatment of these conditions; only drugs, which merely alleviate the symptoms. Read More

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December 2018

Determination of Flavonoid and Proanthocyanidin Profile of Hungarian Sour Cherry.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Institute of Food Technology, University of Debrecen, H-4032 Debrecen, Hungary.

Hungarian sour cherries (SC) are excellent source of anthocyanin (concentrations (100⁻300 mg in 100 g fresh fruit) and melatonin (0.15 mg in 100 g fresh fruit), but other flavonoid derivatives also can be isolated by aqueous alcoholic extraction. We have developed a new process for extracting non-extractable procyanidines bound to the membrane, proteins, and fibers. Read More

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December 2018

Novel Docosahexaenoic Acid Ester of Phloridzin Inhibits Proliferation and Triggers Apoptosis in an In Vitro Model of Skin Cancer.

Antioxidants (Basel) 2018 Dec 11;7(12). Epub 2018 Dec 11.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Skin cancer is among the most common cancer types accompanied by rapidly increasing incidence rates, thus making the development of more efficient therapeutic approaches a necessity. Recent studies have revealed the potential role of decosahexaenoic acid ester of phloridzin (PZDHA) in suppressing proliferation of liver, breast, and blood cancer cell lines. In the present study, we investigated the cytotoxic potential of PZDHA in an in vitro model of skin cancer consisting of melanoma (A375), epidermoid carcinoma (A431), and non-tumorigenic (HaCaT) cell lines. Read More

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December 2018

Mitochondrial Membrane Dynamics-Functional Positioning of OPA1.

Antioxidants (Basel) 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion. One of them, optic atrophy 1 (OPA1), is the mitochondrial inner membrane remodeling protein. Read More

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December 2018

Effect of Agraz ( Swartz) on High-Density Lipoprotein Function and Inflammation in Women with Metabolic Syndrome.

Antioxidants (Basel) 2018 Dec 8;7(12). Epub 2018 Dec 8.

Food and therapeutic alternatives area, Ophidism Program, School of Microbiology, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia.

Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. Read More

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December 2018

Flavonoids and Colorectal Cancer Prevention.

Antioxidants (Basel) 2018 Dec 10;7(12). Epub 2018 Dec 10.

Division of Hematology & Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Abor, MI 48109, USA.

Colorectal cancer (CRC) is the third most common cancer, but despite advances in treatment, it remains the second most common cause of cancer-related mortality. Prevention may, therefore, be a key strategy in reducing colorectal cancer deaths. Given reports of an inverse association between fruit and vegetable consumption with colorectal cancer risk, there has been significant interest in understanding the metabolism and bioactivity of flavonoids, which are highly abundant in fruits and vegetables and account for their pigmentation. Read More

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December 2018

Assessment of Antioxidant Capacity and Putative Healthy Effects of Natural Plant Products Using Soybean Lipoxygenase-Based Methods. An Overview.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Department of the Sciences of Agriculture, Food and Environment, University of Foggia, Via Napoli 25, 71122 Foggia, Italy.

In the last decades, increasing demand of antioxidant-rich foods and growing interest in their putative role in prevention of degenerative diseases have promoted development of methods for measuring Antioxidant Capacity (AC). Nevertheless, most of these assays use radicals and experimental conditions far from the physiological ones, and are able to estimate only one or a few antioxidant mechanisms. On the other hand, the novel LOX/RNO and LOX⁻FL methods, based on secondary reactions between the soybean lipoxygenase (LOX)-1 isoenzyme and either 4-nitroso-,-dimethylaniline (RNO) or fluorescein (FL), may provide a more comprehensive AC evaluation. Read More

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December 2018

Evaluating Antitumor and Antioxidant Activities of Yellow Pigments from Fermentation.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.

Yellow pigments can be of two kinds: Natural and reduced, in which natural yellow pigments (NYMPs) attract widespread attention for their bioactivities. In this study, the antioxidative and antibreast cancer effects of the water-soluble NYMPs fermented by CGMCC 10910 were evaluated. Results showed that water-soluble NYMPs had a significantly improved antioxidative activities compared to the reduced yellow pigments (RYMPs) that were chemically derived from orange or red pigments. Read More

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December 2018

HPLC-ESI-MS/MS Profiling of Polyphenolics of a Leaf Extract from (Zingiberaceae) and Its Anti-Inflammatory, Anti-Nociceptive, and Antipyretic Activities In Vivo.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 44883-2462 Heidelberg, Germany.

Reactive oxygen species (ROS) have been linked to several health conditions, among them inflammation. Natural antioxidants may attenuate this damage. Our study aimed to investigate the chemical composition of a methanol leaf extract from and its possible antioxidant, anti-inflammatory, anti-nociceptive, and antipyretic effects. Read More

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December 2018

Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity.

Can J Physiol Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Slovak Academy of Sciences, Centre of Experimental Medicine, Institute for Heart Research, Bratislava, Slovakia ;

Uncontrolled production of oxygen and nitrogen radicals results in oxidative (OS) and nitrosative (NS) stresses that impair cellular functions and have been regarded as causative common denominators of many pathological processes. In this review, we report on the beneficial effects of molecular hydrogen (H2) in scavenging radicals in an artificial system of ●OH formation. As a proof of principle, we also demonstrate that in rat hearts in vivo, administration of H2 led to a significant increase in SOD as well as pAKT, a cell survival signaling molecule. Read More

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December 2018

The marine Gram-negative bacterium Novosphingobium sp. PP1Y as a potential source of novel metabolites with antioxidant activity.

Biotechnol Lett 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemical Sciences, University Federico II of Naples, Via Cinthia 26, 80127, Naples, Italy.

Objective: The antioxidant activity and protective effect of a methanolic extract obtained from the marine Gram-negative bacterium Novosphingobium sp. PP1Y, isolated from the surface water of a polluted area in the harbour of Pozzuoli (Naples, Italy), was evaluated.

Results: The extract was tested in vitro on epithelial colorectal adenocarcinoma cells and in vivo on Caenorhabditis elegans. Read More

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December 2018

Ameliorative effects of quercetin against bisphenol A-caused oxidative stress in human erythrocytes: an and .

Toxicol Res (Camb) 2018 Nov 22;7(6):1091-1099. Epub 2018 Aug 22.

Department of Botany , Bioinformatics and Climate Change Impacts Management , University School of Sciences , Gujarat University , Ahmedabad-380 009 , Gujarat , India . Email:

Bisphenol A (BPA) is an endocrine disruptor of xenobiotic type, mainly used for the production of polycarbonate plastic, epoxy resins and non-polymer additives. Because of its wide usages in the environment, the toxic effects of BPA have proved to be harmful to human health. However, its effects on human haemoglobin remain unclear. Read More

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November 2018

Therapy with high-dose long-term antioxidant free radicals for severe paraquat poisoning: A pilot study.

Exp Ther Med 2018 Dec 2;16(6):5149-5155. Epub 2018 Oct 2.

Department of Gastroenterology, Xiangyang First People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China.

This study investigated the effects of high-dose long-term antioxidant free radicals on the mortality rate, creatinine (Cr) value, partial pressure of oxygen (PaO), alanine aminotransferase (ALT), as well as the incidence rates of lung fibrosis and dysfunction in the treatment of patients with severe paraquat (PQ) poisoning [toxic dose, 20 ml stock solution (20% w/v)]. A total of 23 cases of severe PQ poisoning treated in Xiangyang First People's Hospital, Hubei University of Medicine were collected (group 1), and they received conventional treatments such as immunosuppressive agents and/or hemoperfusion. Six patients were given high-dose long-term antioxidant therapy on the basis of conventional treatments (group 2). Read More

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December 2018

Prevention of Fish Oil Oxidation.

Authors:
Kazuo Miyashita

J Oleo Sci 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Fisheries Sciences, Hokkaido University.

The benefit of fish oil to health has been widely recognized because of the high contents of functional EPA (20:5n-3) and DHA (22:6n-3) in the oil; however, the application of fish oil has been limited by its high susceptibility to oxidation. This review reports the characteristics of EPA and DHA oxidation compared with those of other fatty acids such as linoleic acid (18:2n-6). In addition, effective approaches to protect against oxidation are discussed, focusing on the unique antioxidant potential of amine compounds. Read More

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December 2018

Relationship between Metal Pollution and Gene Expression of Insulin-like Growth Factor II.

J Health Pollut 2018 Jun 11;8(18):180608. Epub 2018 Jun 11.

Department of Medical Laboratory Technology, Faculty of Allied Medical Science, Pharos University in Alexandria, Egypt.

Background: Metals pollution plays an important role in the regulation of gene expression through interference with signal transduction pathways which are important for cell bioactivity.

Objectives: The present study was conducted to estimate metallothionein levels in mussels as a biomarker of exposure to heavy metals in order to monitor the pollution of Abu Qir Bay, Egypt (El-Maadiya region) and to evaluate the impact of heavy metals on human health by examining insulin-like growth factor II (IGF-2) gene expression in peripheral blood mononuclear cells.

Methods: One hundred and forty mussel samples () were collected from Abu-Qir Bay, stored in bags, preserved in an ice box, and then transported to the laboratory to acclimatize at 20°C for three days in ethylene diamine tetra acetic acid (EDTA)-free synthetic sea water to determine the presence of metallothionein and five other metals (cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu) and zinc (Zn)). Read More

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Ameliorating effect of encapsulated hepatocyte-like cells derived from umbilical cord in high mannuronic alginate scaffolds on acute liver failure in rats.

Iran J Basic Med Sci 2018 Sep;21(9):928-935

Transplantation Ward, Ahvaz Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objectives: In this study, effects of encapsulated umbilical cord stem cells (UCSCs)-derived hepatocyte-like cells (HLCs) in high mannuronic alginate scaffolds was investigated on CCl-induced acute liver failure (ALF) in rats.

Material And Methods: UCSCs were encapsulated in high mannuronic alginate scaffolds. Then the UCSCs differentiated into HLCs for treatment of CCl-induced ALF in rats. Read More

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September 2018

Camel whey protein enhances lymphocyte survival by modulating the expression of survivin, bim/bax, and cytochrome C and restores heat stress-mediated pathological alteration in lymphoid organs.

Iran J Basic Med Sci 2018 Sep;21(9):896-904

Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia.

Objectives: Heat stress (HS) is a catastrophic stressor that dampens immunity. The current study investigates the effect of dietary administration with camel whey protein (CWP) on apoptotic pathway caused by HS.

Materials And Methods: Forty-five male mice were divided into three groups: a control group; HS group; and HS mice that were orally supplemented with CWP (CWP-HS group). Read More

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September 2018

Evaluation of free radical scavenging capacity of methoxy containing-hybrids of thiosemicarbazone-triazole and their influence on glucose transport.

BMC Pharmacol Toxicol 2018 Dec 6;19(1):84. Epub 2018 Dec 6.

Department of Biochemistry, North-West University, Mmabatho, 2735, South Africa.

Background: Diabetes mellitus is a metabolic disease in which the body is unable to produce insulin or respond to insulin production, consequently leading to abnormal metabolism of carbohydrates, lipids and proteins causing elevation of glucose in the blood. Oxidative stress, an imbalance between the production of free radicals and body antioxidant system has been implicated in the pathogenesis of diabetes. Free radicals attack important macromolecules leading to cell damage. Read More

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December 2018

(+)-Catechin potentiates the oxidative response of Acinetobacter baumannii to quinolone-based antibiotics.

Microb Pathog 2018 Dec 9. Epub 2018 Dec 9.

Antioxidants, Redox Biology and Toxicology Research Laboratory, Department of Medical Biochemistry, College of Health Sciences, Nile University of Nigeria, Nigeria. Electronic address:

(+)-Catechin is a versatile compound with its pharmacophore (catechol and resorcinol) responsible for prooxidant and antibacterial activities. In this study, we present that demonstrating the synergistic interaction between (+)-catechin and quinolone-based antibiotics, ciprofloxacin and gemifloxacin is related to reactive oxygen species generation. The minimum inhibitory concentration of (+)-catechin against Acinetobacter baumannii AB5075 were considerably lowered for ΔsodB and ΔkatG mutants. Read More

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December 2018

Housefly (Musca domestica) larvae powder, preventing oxidative stress injury via regulation of UCP4 and CyclinD1 and modulation of JNK and P38 signaling in APP/PS1 mice.

Food Funct 2018 Dec 12. Epub 2018 Dec 12.

School of Basic Courses, Guangzhou, Guangdong 510006, China and Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou, Guangdong 510006, China and Department of Biochemistry and Molecular Biology, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong 510006, China.

Housefly (Musca domestica) Larvae powder (HL) is rich in antioxidants. As oxidative stress is considered as one of the main pathogenesis in Alzheimer's Disease (AD), this study was designed to explore the protective effects of HL as an antioxidant on APP/PS1 mice. 2-Month-old APP/PS1 mice were divided into a model control (MC) group, a Donepezil group and a HL group, and C57BL/6 mice were used as the normal control (NC) group. Read More

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December 2018
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Oxidative stress: therapeutic approaches for cervical cancer treatment.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e548s. Epub 2018 Dec 10.

Instituto do Cancer do Estado de Sao Paulo ICESP, Centro de Investigacao Translacional em Oncologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. Read More

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December 2018
1 Read

Essential oils and functional herbs for healthy aging.

Neural Regen Res 2019 Mar;14(3):441-445

School of Pharmacy and Applied Science, La Trobe Institute for Molecular Sciences, La Trobe University, Bendigo, Australia.

As total life expectancy increases, the prevalence of age-related diseases such as diabetes and Alzheimer's disease is also increasing. Many hypotheses about Alzheimer's disease have been developed, including cholinergic neuron damage, oxidative stress, and inflammation. Acetylcholine is a major neurotransmitter in the brain and cholinergic deficits leads to cognitive dysfunction and decline. Read More

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March 2019
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Liberation of Hydrogen Sulfide from Dicysteinyl Polysulfanes in Model Wine.

J Agric Food Chem 2018 Dec 12. Epub 2018 Dec 12.

44 Sandwich Road , Ash, Canterbury , Kent CT3 2AF , United Kingdom.

Diorganopolysulfanes can be generated when hydrogen sulfide (HS) and thiols are oxidized in the presence of Cu(II) under conditions usually aimed at removing HS from wine. This work sought to understand if polysulfanes could act as latent sources of HS during postbottling storage. The stability of the polysulfanes formed in situ in model wine containing cysteine, HS, and transition metals was dependent both on the number of sulfur linking atoms (S) and on the presence of a reducing agent, such as sulfur dioxide or ascorbic acid. Read More

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December 2018

Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice ().

Clin Exp Reprod Med 2018 Dec 30;45(4):163-169. Epub 2018 Nov 30.

American Center for Reproductive Medicine, Urological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. Read More

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December 2018

Extraction, Characterization, Antioxidant, and Immunostimulatory Activities of Polysaccharides from .

Evid Based Complement Alternat Med 2018 14;2018:8617070. Epub 2018 Nov 14.

College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

In this study, optimization of enzyme-assisted extraction, purification, characterization, and its bioactivities of polysaccharides from (HCP) was investigated. It was found that the optimum extraction conditions were 3% of enzyme concentration ( ), 30 of liquid-to-solid ratio ( ), 56°C of extraction temperature ( ), 200W of ultrasonic power ( ), 10 min of extraction time ), and 5 of pH value ( ). Under optimum conditions, the experimental yield (4. Read More

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November 2018

Potential effects of different natural antioxidants on inflammatory damage and oxidative-mediated hepatotoxicity induced by gold nanoparticles.

Int J Nanomedicine 2018 23;13:7931-7938. Epub 2018 Nov 23.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Objective: The objective of this study was to verify and confirm the oxidative-mediated hepatotoxicity, inflammatory liver damage, and oxidative stress induced by intraperitoneal administration of gold nanoparticles (GNPs) in vivo; characterize the effect of different natural antioxidants on these hazardous changes; and finally choose the most powerful antioxidant among these different natural antioxidants.

Methods: Ten-nanometer GNPs were dissolved in aqueous solution of 0.01% concentration. Read More

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November 2018

Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo.

Int J Nanomedicine 2018 21;13:7765-7770. Epub 2018 Nov 21.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and investigate the potential roles of quercetin (Qur) and arginine (Arg) in mitigating the inflammatory kidney damage and dysfunction and inhibiting the toxicity induced by GNPs in rats.

Methods: Kidney function was assessed using various serum biomarkers, including blood urea nitrogen (BUN), uric acid (URIC), and creatinine (CR), while toxicity was evaluated by measuring the biomarkers glutathione (GSH) and malondialdehyde (MDA) in kidney tissues.

Results: Administration of GNPs to the rats severely affected the serum kidney biomarkers, as confirmed by the notable increases in BUN, URIC, and CR. Read More

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November 2018

Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells.

Lipids Health Dis 2018 Dec 11;17(1):280. Epub 2018 Dec 11.

University of Information Technology and Management in Rzeszow, Kielnarowa 386a, 36-020, Tyczyn, Poland.

Background: Extracts from plants, rich in antioxidants may be used as active ingredients of many preparations, mainly due to their antioxidant, regenerative and anti-aging properties. The work involved a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract as a multifunctional raw material. Read More

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December 2018

In Vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. Read More

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December 2018
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Exogenous alpha lipoic acid can stimulate photosystem II activity and the gene expressions of carbon fixation and chlorophyll metabolism enzymes in maize seedlings under drought.

J Plant Physiol 2018 Nov 29;232:65-73. Epub 2018 Nov 29.

Department of Biology, Faculty of Science, Karadeniz Technical University, 61080, Trabzon, Turkey. Electronic address:

Protective compounds such as non-enzymatic antioxidants, osmolytes and signal molecules have been applied to plants exposed to various environmental stresses to increase their stress tolerance. However, there are not enough records about the response of plants to alpha lipoic acid (ALA) application with antioxidant properties. Therefore, this study was designed to evaluate the function of exogenous ALA on the photosynthetic performance of maize seedlings grown in hydroponic conditions under drought stress. Read More

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November 2018
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Drought tolerance in alfalfa (Medicago sativa L.) varieties is associated with enhanced antioxidative protection and declined lipid peroxidation.

J Plant Physiol 2018 Oct 31;232:226-240. Epub 2018 Oct 31.

College of Grassland Science, Key Laboratory of Grassland Ecosystem (Ministry of Education), Pratacultural Engineering Laboratory of Gansu Province, Sino-U.S. Centers for Grazing Land Ecosystem Sustainability, Gansu Agricultural University, Lanzhou, 730070, China.

Drought stress is considered the most adverse factor restricting plant survival, growth, and productivity. The identification of the key adaptive mechanisms to drought stress is essential to enhance the drought resistance of plants. In this study, differential responses of three alfalfa varieties to drought, including Medicago sativa L. Read More

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October 2018
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Markers of Accelerated Skeletal Muscle Regenerative Response in MRL/MpJ Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors.

Stem Cells 2018 Dec 10. Epub 2018 Dec 10.

Department of Orthopaedic Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

The "super-healing" Murphy Roths Large (MRL/MpJ) mouse possesses a superior regenerative capacity for repair of many tissues, which makes it an excellent animal model for studying molecular and cellular mechanisms during tissue regeneration. Since the role of muscle progenitor cells (MPCs) in muscle healing capacity of MRL/MpJ mice has not been previously studied, we investigated the muscle regenerative capacity of MRL/MpJ mice following muscle injury, and the results were compared to results from C57BL/6 J (B6) age-matched control mice. Our results show that muscle healing upon cardiotoxin injury was accelerated in MRL/MpJ mice and characterized by reduced necrotic muscle area, reduced macrophage infiltration, and more regenerated myofibers (eMyHC+/centronucleated fibers) at 3, 5, and 12 days post-injury, when compared to B6 age-matched control mice. Read More

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December 2018

Menadione perturbs oxidative stress biomarkers and testicular function indices of rats.

J Biochem Mol Toxicol 2018 Dec 10:e22282. Epub 2018 Dec 10.

Antioxidants, Redox Biology, and Toxicology Research Laboratory, Department of Medical Biochemistry, College of Health Sciences, Nile University of Nigeria, FCT-Abuja, Nigeria.

In this study, we evaluated the influence of menadione on the androgenic, oxidative stress biomarkers, and testicular function indices in rats. Rats (20) were randomized into four groups (A-D) of five rats each. Rats in groups A, B, C, and D received the vehicle of administration (olive oil), 25, 50, or 100 mg/kg body weight menadione intraperitoneally, respectively, for 7 days. Read More

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December 2018
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Single-dose β-aminobutyric acid treatment modifies tobacco (Nicotiana tabacum L.) leaf acclimation to consecutive UV-B treatment.

Photochem Photobiol Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Plant Biology, University of Pécs, Hungary.

β-Aminobutyric acid (BABA) pre-treatment has been shown to alter both biotic and abiotic stress responses. The present study extends this observation to acclimative UV-B-response, which has not been explored in this context so far. A single soil application of 300 ppm BABA modified the non-enzymatic antioxidant capacities and the leaf hydrogen peroxide levels in tobacco (Nicotiana tabacum L. Read More

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December 2018

Studies of human hemoglobin modified with peroxynitrite: A cytotoxic metabolite generated in numerous disorders.

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):30-35

Department of Biochemistry and Biotechnology, SBS Postgraduate Institute of Biomedical Sciences and Research, Balawala, Dehradun, India.

Objectives: Peroxynitrite interacts with biomolecules through oxidative reactions or radical-mediated mechanisms leading to oxidative damage and committing cells to necrosis or/and apoptosis. Hemoglobin (Hb) is the oxygen-transporting metalloprotein found in blood that carries oxygen from the lungs to the tissues and subsequently releases it to carry out various metabolic functions. In the present study, we have isolated Hb from human blood and subjected it to modify by peroxynitrite generated . Read More

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December 2018

Ketogenic diet increases mitochondria volume in the liver and skeletal muscle without altering oxidative stress markers in rats.

Heliyon 2018 Nov 24;4(11):e00975. Epub 2018 Nov 24.

School of Kinesiology, Auburn University, Auburn, AL, USA.

Ketogenic diets (KD) consist of high fat, moderate protein and low carbohydrates. Studies have suggested that KD may influence oxidative stress by affecting mitochondrial quantity and/or quality, and perhaps lengthen lifespan. Therefore, we determined the effects of KD on multi-organ mitochondria volume and oxidative stress markers in rats. Read More

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November 2018

Reactive Oxygen Species, Biomarkers of Microvascular Maturation and Alveolarization, and Antioxidants in Oxidative Lung Injury.

React Oxyg Species (Apex) 2018 Nov;6(18):373-388

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.

The lungs of extremely low gestational age neonates (ELGANs) are deficient in pulmonary surfactant and are incapable of efficient gas exchange necessary for successful transition from a hypoxic intrauterine environment to ambient air. To improve gas exchange and survival, ELGANs often receive supplemental oxygen with mechanical ventilation which disrupts normal lung developmental processes, including microvascular maturation and alveolarization. Factors that regulate these developmental processes include vascular endothelial growth factor and matrix metalloproteinases, both of which are influenced by generation of oxygen byproducts, or reactive oxygen species (ROS). Read More

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November 2018

Supplementation of whole grain flaxseeds () along with high cholesterol diet and its effect on hyperlipidemia and initiated atherosclerosis in Wistar albino male rats.

Vet World 2018 Nov 17;11(10):1433-1439. Epub 2018 Oct 17.

Department of Nanotechnology, Frontier Institute of Technology, RARS, Tirupati, Andhra Pradesh, India.

Background And Aim: Flaxseeds are known to have varying antihypercholesterolemic and antiatherogenic activity due to its lignan secoisolariciresinol diglucoside, alpha-linolenic acid, and omega-3 fatty acids. The beneficial effect of whole grain dietary flaxseed was evaluated experimentally in high cholesterol diet (HCD)-fed Wistar albino rats.

Materials And Methods: Male Wistar albino rats (200 g) were divided into four groups of 12 rats each. Read More

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November 2018

Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development.

PLoS Comput Biol 2018 Dec 10;14(12):e1006672. Epub 2018 Dec 10.

Laboratory of Neurogenetics, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint-Petersburg, Russia.

Kynurenines, the products of tryptophan oxidative degradation, are involved in multiple neuropathologies, such as Huntington's chorea, Parkinson's disease, senile dementia, etc. The major cause for hydroxykynurenines's neurotoxicity is the oxidative stress induced by the reactive oxygen species (ROS), the by-products of L-3-hydroxykynurenine (L-3HOK) and 3-hydroxyanthranilic acid (3HAA) oxidative self-dimerization. 2-aminophenol (2AP), a structural precursor of L-3HOK and 3HAA, undergoes the oxidative conjugation to form 2-aminophenoxazinone. Read More

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December 2018
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Pravastatin attenuates testicular damage induced by doxorubicin - a stereological and histopatological study.

J Basic Clin Physiol Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background The aim of this study is to investigate the effects of pravastatin (PS) against doxorubicin (DOX)-induced testicular toxicity. Methods A total of 24 healthy male Sprague-Dawley rats were equally divided into four groups. Group I received normal saline, Group II received PS (20 mg/kg b. Read More

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December 2018

Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities.

Biomed Pharmacother 2018 Dec 6;110:510-517. Epub 2018 Dec 6.

School of Life Sciences, Anhui University, 111 Jiulong Road, Hefei 230601, PR China.

The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). Read More

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December 2018

Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.

Biomed Pharmacother 2018 Dec 5;110:409-419. Epub 2018 Dec 5.

Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519, Egypt. Electronic address:

Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. Read More

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December 2018
2.023 Impact Factor

Cross-talk between physiological and biochemical adjustments by Punica granatum cv. Dente di cavallo mitigates the effects of salinity and ozone stress.

Sci Total Environ 2018 Nov 28;656:589-597. Epub 2018 Nov 28.

National Research Council, Via Madonna del Piano 10, Sesto Fiorentino, Florence 50019, Italy.

Plants are exposed to a broad range of environmental stresses, such as salinity and ozone (O), and survive due to their ability to adjust their metabolism. The aim of this study was to evaluate the physiological and biochemical adjustments adopted by pomegranate (Punica granatum L. cv. Read More

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November 2018