484,501 results match your criteria Antioxidants & redox signaling[Journal]


Glycyrrhizic acid renders robust neuroprotection in rodent model of vascular dementia by controlling oxidative stress and curtailing cytochrome-c release.

Nutr Neurosci 2019 Feb 22:1-16. Epub 2019 Feb 22.

a Department of Anatomy, Dr. Arcot Lakshmanaswamy Mudaliar Post Graduate Institute of Basic Medical Sciences , University of Madras , Chennai , India.

Background: Chronic cerebral hypoperfusion (CCH), a concern for neurocognitive health, is linked to various vascular ailments and other comorbidities. This study primarily aims to explain the mitigating effects of glycyrrhizic acid (GA) on cognitive health challenged by chronic cerebral hypoperfusion.

Methods: Adult male Sprague Dawley rats were allocated into four groups: (i) Sham, (ii) Lesion (2VO), (iii) GA treated (20 mg/kg), and (iv) lithium chloride (Li) treated (40 mg/kg). Read More

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http://dx.doi.org/10.1080/1028415X.2019.1580935DOI Listing
February 2019

Microencapsulation of antioxidant phenolic compounds from green coffee.

Prep Biochem Biotechnol 2019 Feb 22:1-7. Epub 2019 Feb 22.

a Department of Spice and Flavour Science , CSIR-Central Food Technological Research Institute , Mysore , India.

Green coffee is a prime source of antioxidants to functional food and nutraceuticals. Arabica and Robusta varieties were screened and decaffeinated using ethyl lactate and extracted with a polar solvent to obtain chlorogenic acid (CGA) enriched green coffee extract (GCE). The physicochemical qualities (moisture, pH, particle size, and color) and bioactive compounds (total phenolics, chlorogenic acid, and caffeine) of GCE were assessed. Read More

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http://dx.doi.org/10.1080/10826068.2019.1575858DOI Listing
February 2019

Impact of CH223191-induced mitochondrial dysfunction on its aryl hydrocarbon receptor agonistic and antagonistic activities.

Chem Res Toxicol 2019 Feb 22. Epub 2019 Feb 22.

The mechanisms underlying aryl hydrocarbon receptor (AHR) activation by agonists and circumstances that increase the sensitivity toward agonists and AHR inhibition by antagonists are diverse and still not fully understood. AHR antagonist, 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide, CH223191, has been reported to inhibit the AHR transcription activity. However, CH223191 antagonist activity toward an AHR endogenous ligand, 6-formylindolo[3,2-b]carbazole (FICZ), and its mode of action remain to be elusive. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.8b00371DOI Listing
February 2019

The Influence of Oxidative Stress and Natural Antioxidants on Morphometric Parameters of Red Blood Cells, the Hemoglobin Oxygen Binding Capacity, and the Activity of Antioxidant Enzymes.

Biomed Res Int 2019 16;2019:2109269. Epub 2019 Jan 16.

Federal State-Financed Academic Institution of Higher Education "National Research Ogarev Mordovia State University", Saransk 430005, Russia.

Using a wide range of different physical and chemical methods, it was found that the oxidative stress caused by addition of hydrogen peroxide to the incubation medium has a significant effect on the conformation of haematoporphyrin, influencing the oxygen-binding properties of haemoglobin in red blood cells. Morphofunctional characteristics of red blood cells change; in particular, we have observed the transformation of erythrocytes, their transition into echinocytes. In erythrocytes, in response to increased lipid peroxidation (LPO) antioxidant enzymes become active. Read More

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http://dx.doi.org/10.1155/2019/2109269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354144PMC
January 2019

The MYB transcription factor PbMYB12b positively regulates flavonol biosynthesis in pear fruit.

BMC Plant Biol 2019 Feb 21;19(1):85. Epub 2019 Feb 21.

College of Horticulture, Northwest A&F University, Taicheng Road NO.3, Yangling, Shaanxi Province, China.

Background: As a class of natural antioxidants in plants, fruit flavonol metabolites are beneficial to human health. However, the regulatory networks for flavonol biosynthesis in most fruits are largely unknown. Previously, we reported a spontaneous pear bud sport 'Red Zaosu' (Pyrus bretschneideri Rehd. Read More

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http://dx.doi.org/10.1186/s12870-019-1687-0DOI Listing
February 2019

Comparison of the Phenolic Profiles of Soaked and Germinated Peanut Cultivars via UPLC-QTOF-MS.

Antioxidants (Basel) 2019 Feb 20;8(2). Epub 2019 Feb 20.

Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.

Diverse peanut varieties are widely cultivated in China. However, few studies have investigated the effects of germination on the phenolic profiles and antioxidant activities of specific Chinese peanut cultivars. Therefore, this study was conducted to evaluate the effects of germination on total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, and phenolic profiles of seven peanut cultivars in China. Read More

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http://dx.doi.org/10.3390/antiox8020047DOI Listing
February 2019

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes.

Nanomaterials (Basel) 2019 Feb 19;9(2). Epub 2019 Feb 19.

Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia.

Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Read More

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http://dx.doi.org/10.3390/nano9020296DOI Listing
February 2019

Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism.

Free Radic Biol Med 2019 Feb 18. Epub 2019 Feb 18.

Indiana University School of Medicine - South Bend Center, South Bend, IN, 46617, USA.

Elaborate antioxidant pathways have evolved to minimize the threat of excessive reactive oxygen species (ROS) and to regulate ROS as signaling entities. ROS are chemically and functionally similar to reactive sulfide species (RSS) and both ROS and RSS have been shown to be metabolized by the antioxidant enzymes, superoxide dismutase and catalase. Here we use fluorophores to examine the effects of a variety of inhibitors of antioxidant pathways on metabolism of two important RSS, hydrogen sulfide (HS with AzMC) and polysulfides (HS, where n = 2-7, with SSP4) in HEK293 cells. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.011DOI Listing
February 2019

An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury.

Free Radic Biol Med 2019 Feb 18;134:630-643. Epub 2019 Feb 18.

Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop Street, Scaife Hall, Pittsburgh, 15213, USA. Electronic address:

Traumatic Brain Injury (TBI) affects more than 1.7 million Americans each year and about 30% of TBI-patients having visual impairments. The loss of retinal ganglion cells (RGC) in the retina and axonal degeneration in the optic nerve have been attributed to vision impairment following TBI; however, the molecular mechanism has not been elucidated. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.02.015DOI Listing
February 2019

Antioxidants for Pancreatic Functions in Chronic Pancreatitis: A Double-blind Randomized Placebo-controlled Pilot Study.

J Clin Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Gastroenterology and Human Nutrition Unit.

Background: Antioxidants (AO) supplementation in chronic pancreatitis (CP) has been evaluated for pain. But it is not clear whether AO in CP have an effect on pancreatic functions and other clinical outcomes. We evaluated effect of AO on endocrine function in CP. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001178DOI Listing
February 2019

Intake of Antioxidants in Relation to Infertility Treatment Outcomes with Assisted Reproductive Technologies.

Epidemiology 2019 Feb 15. Epub 2019 Feb 15.

Background: Randomized trials of supplementation with antioxidant mixtures during infertility treatment show no benefit on pregnancy or live birth rate. However, the roles of individual antioxidants are poorly understood. We examined the association of baseline intake of vitamins A, C, E, and carotenoids with outcomes of assisted reproductive technologies (ART). Read More

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http://dx.doi.org/10.1097/EDE.0000000000000976DOI Listing
February 2019

Cortisol predicts migration timing and success in both Atlantic salmon and sea trout kelts.

Sci Rep 2019 Feb 20;9(1):2422. Epub 2019 Feb 20.

DTU Aqua, National Institute of Aquatic Resources, Section for Freshwater Fisheries Ecology, Technical University of Denmark, , Vejlsøvej 39, 8600, Silkeborg, Denmark.

Kelts - individuals of anadromous fish species which have successfully spawned and may return to sea to repeat the cycle - are perhaps the least studied life stage of iteroparous fish species. To date, our understanding of what makes them successful in their return migration to sea is limited. We investigated the relationship between three physiological parameters (baseline cortisol, baseline glucose and low molecular weight antioxidants) and the timing and success of Atlantic salmon (Salmo salar) and sea trout (Salmo trutta) kelt migration. Read More

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http://dx.doi.org/10.1038/s41598-019-39153-xDOI Listing
February 2019

The effect of natural and synthetic antioxidants and packaging type on the quality of cooked poultry products during frozen storage.

Food Sci Technol Int 2019 Feb 20:1082013219830196. Epub 2019 Feb 20.

Department of Human Nutrition, University of Warmia and Mazury, Olsztyn, Poland.

The effect of oil-soluble rosemary extract, sodium erythorbate and their mixture, and the influence of packaging method (air and vacuum packaging) on the quality of cooked turkey meatballs stored at -20 ℃ was determined. The smallest changes in malondialdehyde content were observed in samples with the addition of the natural antioxidant regardless of the packaging method. The mixture of synthetic and natural antioxidants was more effective in retarding lipid oxidation than the synthetic antioxidant, and more desirable results were observed in vacuum-packaged samples than in air-packaged samples. Read More

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http://dx.doi.org/10.1177/1082013219830196DOI Listing
February 2019

Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.

Pharmacol Biochem Behav 2019 Feb 17. Epub 2019 Feb 17.

Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903 Blumenau, Santa Catarina, Brazil.

Depression is a neuropsychiatry medical condition with high prevalence, in which the hypothalamic-pituitary-adrenal axis dysfunction has been postulated as the main cause. The glucocorticoids can be harmful to the brain, particularly by induction of oxidative stress and glutamatergic damage, therefore antioxidants or neuroprotective agents could have beneficial effects. Lutein (LUT) is a dietary xanthophyll able to arrive in the brain that has been used for therapy of macular degeneration. Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.004DOI Listing
February 2019

Functional analysis finds differences on the muscle transcriptome of pigs fed an n-3 PUFA-enriched diet with or without antioxidant supplementations.

PLoS One 2019 20;14(2):e0212449. Epub 2019 Feb 20.

Interdepartmental Centre for Industrial Agrifood Research (CIRI- AGRO), University of Bologna, Cesena, Italy.

Supplementing pig diets with n-3 polyunsaturated fatty acids (n-3 PUFA) may produce meat products with an increased n-3 fatty acid content, and the combined antioxidants addition could prevent lipid oxidation in the feed. However, to date, the effects of these bioactive compounds at the molecular level in porcine skeletal muscle are mostly unknown. This study aimed to analyse changes in the Longissimus thoracis transcriptome of 35 pigs fed three diets supplemented with: linseed (L); linseed, vitamin E and Selenium (LES) or linseed and plant-derived polyphenols (LPE). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212449PLOS
February 2019

Synthesis of Rosmarinic Acid Amides as Antioxidative and Hypoglycemic Agents.

J Nat Prod 2019 Feb 20. Epub 2019 Feb 20.

Type 2 diabetes mellitus (T2DM) is an important metabolic disorder for which there is an urgent need for new antidiabetic drugs. α-Glucosidase inhibition is an established protocol for T2DM therapy. Because hyperglycemia causes oxidative tissue damage, the development of agents with both α-glucosidase inhibition and antioxidant activity from natural or natural-derived polyphenols such derivatives of rosmarinic acid (RA) represents an attractive therapeutic option. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b01002DOI Listing
February 2019

Selenium protects wheat seedlings against salt stress-mediated oxidative damage by up-regulating antioxidants and osmolytes metabolism.

Plant Physiol Biochem 2019 Feb 8;137:144-153. Epub 2019 Feb 8.

Botany Department, Faculty of Science, Tanta University, Tanta, Egypt; Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom.

Salinity stress hampers the growth of most crop plants and reduces yield considerably. Therefore, experiments were conducted on wheat (Triticum aestivum L.) plants for studying the role of selenium (5 and 10 μM Se) supplementation in strengthening the salinity stress tolerance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09819428193005
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http://dx.doi.org/10.1016/j.plaphy.2019.02.004DOI Listing
February 2019
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Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.

Eur J Med Chem 2019 Feb 6;167:525-545. Epub 2019 Feb 6.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal. Electronic address:

Alzheimer's disease is an irreversible, complex and progressive neurodegenerative disorder associated with oxidative stress and mitochondrial dysfunction. Exogenous antioxidants can be beneficial for decreasing oxidative stress, as they are able to reward the lack of efficacy of the endogenous defense systems and raise the overall antioxidant response in a pathological condition. Along our overarching project related with the design and development of potent and safe multi-target mitochondriotropic antioxidants, based on dietary antioxidants, novel derivatives were obtained. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.055DOI Listing
February 2019

Binding of Plant Polyphenols to Serum Albumin and LDL: Healthy Implications for Heart Disease.

J Agric Food Chem 2019 Feb 20. Epub 2019 Feb 20.

Cardiovascular disease (CVD) is the leading cause of death in industrialized nations. The initiating event in atherosclerosis or hardening of the arteries, is oxidation of low density lipoprotein (LDL). Binding with serum albumin and LDL of 41 polyphenols (major antioxidants in plant foods) constituting four classes of flavonoids, three types of phenolic acids and seven polyphenol conjugate metabolites was investigated indirectly by fluorescence quenching and directly by affinity separation/HPLC (four of the polyphenols). Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06674DOI Listing
February 2019

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats.

Drug Chem Toxicol 2019 Feb 20:1-7. Epub 2019 Feb 20.

b Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine , Aswan University , Sahari , Aswan , Egypt.

Fluoroquinolones are some of the most common antibiotics used by clinicians all over the world. Levofloxacin, a fluoroquinolone, is used therapeutically in numerous countries; however, it can cause an increase in liver function tests and liver dysfunction. The current study was designed to determine the effect of Levofloxacin (40 mg/kg body weight (b. Read More

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http://dx.doi.org/10.1080/01480545.2019.1574811DOI Listing
February 2019

Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice.

Hum Exp Toxicol 2019 Feb 19:960327119831067. Epub 2019 Feb 19.

1 Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sfax, Tunisia.

Vanillin, a widely used flavoring agent, has antimutagenic and antioxidant properties. The current study was performed to evaluate its beneficial role against hepatotoxicity induced by maneb, a dithiocarbamate fungicide. Mice were divided into four groups of six each: group 1, serving as negative controls which received by intraperitoneal way only distilled water, a solvent of maneb; group 2, received daily, by intraperitoneal way, maneb (30 mg kg body weight (BW)); group 3, received maneb at the same dose of group 2 and 50 mg kg BW of vanillin by intraperitoneal way; and group 4, serving as positive controls, received daily only vanillin. Read More

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http://dx.doi.org/10.1177/0960327119831067DOI Listing
February 2019

RBOH-dependent ROS synthesis and ROS scavenging by plant specialized metabolites to modulate plant development and stress responses.

Chem Res Toxicol 2019 Feb 20. Epub 2019 Feb 20.

Reactive Oxygen Species (ROS) have recently been shown to regulate plant growth and development. ROS are kept at low levels in cells to prevent oxidative damage, allowing them to be effective signaling molecules upon increased synthesis. In plants and animals, NADPH Oxidase/Respiratory Burst Oxidase proteins provide localized ROS bursts to regulate growth, developmental processes, and stress responses. Read More

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http://dx.doi.org/10.1021/acs.chemrestox.9b00028DOI Listing
February 2019

Lipid Peroxidation: Analysis and Applications in Biological Systems.

Antioxidants (Basel) 2019 Feb 13;8(2). Epub 2019 Feb 13.

Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS Université de Montpellier, ENSCM, F-34093 Montpellier, France.

Lipid peroxidation is an ambiguous event in all biological species [... Read More

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http://dx.doi.org/10.3390/antiox8020040DOI Listing
February 2019

From Ecology to Biotechnology, Study of the Defense Strategies of Algae and Halophytes (from Trapani Saltworks, NW Sicily) with a Focus on Antioxidants and Antimicrobial Properties.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Dipartimento di Scienze della terra e del Mare DiSTeM, Laboratorio di Biochimica Marina ed Ecotossicologia, Università degli Studi di Palermo, Via G. Barlotta 4, 91100 Trapani, Italy.

This study aimed at the characterization of the antioxidant power of polyphenol extracts (PE) obtained from the algae (CYS) (Phaeophyta) and from the halophyte (HAL), growing in the solar saltworks of western Sicily (Italy), and at the evaluation of their anti-microfouling properties, in order to correlate these activities to defense strategies in extreme environmental conditions. The antioxidant properties were assessed in the PE based on the total antioxidant activity test and the reducing power test; the anti-microfouling properties of the two PE were evaluated by measuring the growth inhibition of marine fish and shellfish pathogen bacteria as well as marine surface fouling bacteria and microalgae exposed to the fractions. Similar polyphenol content (CYS 5. Read More

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http://dx.doi.org/10.3390/ijms20040881DOI Listing
February 2019

The Effectiveness of Vitamin E Treatment in Alzheimer's Disease.

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Department of Clinic Neurophysiology, University Clinic Hospital of Valencia, Avda. Blasco Ibanez, 19, 46010 Valencia, Spain.

Vitamin E was proposed as treatment for Alzheimer's disease many years ago. However, the effectiveness of the drug is not clear. Vitamin E is an antioxidant and neuroprotector and it has anti-inflammatory and hypocholesterolemic properties, driving to its importance for brain health. Read More

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http://dx.doi.org/10.3390/ijms20040879DOI Listing
February 2019
2.862 Impact Factor

Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System.

Antioxidants (Basel) 2019 Feb 18;8(2). Epub 2019 Feb 18.

Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Asturias 33006, Spain.

Differential antioxidant action is found upon comparison of organ/tissue systems in the human body. In erythrocytes (red blood cells), which transport oxygen and carbon dioxide through the circulatory system, the most important issue is to keep hemoglobin in a functional state that requires maintaining the haem group in ferrous (Fe) state. Conversion of oxidized Fe back into Fe in hemoglobin needs a special mechanism involving a tripeptide glutathione, glucose-6-phosphate dehydrogenase, and glucose and NADPH as suppliers of reducing power. Read More

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http://dx.doi.org/10.3390/antiox8020046DOI Listing
February 2019

Nutraceutical Characteristics of Ancient x Borkh. Fruits Recovered across Siena in Tuscany.

Medicines (Basel) 2019 Feb 18;6(1). Epub 2019 Feb 18.

Department of Life Sciences, University of Siena, I-53100 Siena, Italy.

A diet rich in fruits and vegetables contributes to lowering the risk of chronic diseases. The fruits of Malus x domestica are a rich dietary source of bioactive compounds, namely vitamins and antioxidants, with recognized action on human health protection. Tuscany is known for its rich plant biodiversity, especially represented by ancient varieties of fruit trees. Read More

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http://dx.doi.org/10.3390/medicines6010027DOI Listing
February 2019

Wine Lees as a Source of Antioxidant Compounds.

Antioxidants (Basel) 2019 Feb 16;8(2). Epub 2019 Feb 16.

Instituto de Investigaciones Vitivinícolas y Agroalimentarias (IVAGRO), Universidad de Cádiz, Campus de Puerto Real, 11510 Cádiz, Spain.

The winemaking industry produces large amount of byproducts, including grape pomace, stalks, and lees. Wine lees are a natural source of phenolic compounds, which have important antioxidant and biological properties. Due to the high quantities produced worldwide, this byproduct can be an ideal raw material for obtaining phenolic compounds that could be of interest in the food and pharmaceutical industries. Read More

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http://dx.doi.org/10.3390/antiox8020045DOI Listing
February 2019

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.

Antioxidants (Basel) 2019 Feb 16;8(2). Epub 2019 Feb 16.

School of Pharmacy, Liverpool John Moores University, L3 5UA Liverpool, UK.

Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Read More

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http://dx.doi.org/10.3390/antiox8020044DOI Listing
February 2019

Reply to "Comment on Ahmad, I.M. et al. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. , 2019, , 12".

Authors:
Iman M Ahmad

Antioxidants (Basel) 2019 Feb 16;8(2). Epub 2019 Feb 16.

Department of Medical Imaging and Therapeutic Sciences, College of Allied Health Professions, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.

Bevelacqua and Mortazavi [... Read More

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http://dx.doi.org/10.3390/antiox8020043DOI Listing
February 2019

Comments on Ahmad, I.M. et al. Healthcare Workers Occupationally Exposed to Ionizing Radiation Exhibit Altered Levels of Inflammatory Cytokines and Redox Parameters. , 2019, , 12.

Antioxidants (Basel) 2019 Feb 15;8(2). Epub 2019 Feb 15.

Medical Physics Department, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran.

This commentary is regarding the paper recently published by Ahmad et al [... Read More

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http://dx.doi.org/10.3390/antiox8020042DOI Listing
February 2019

Bioactive Phenolic Compounds from the Agroindustrial Waste of Colombian Mango Cultivars 'Sugar Mango' and 'Tommy Atkins'-An Alternative for Their Use and Valorization.

Antioxidants (Basel) 2019 Feb 15;8(2). Epub 2019 Feb 15.

Department of Chemistry, Faculty of Sciences, Universidad Nacional de Colombia, Carrera 30 No 45-03, Bogotá D.C. 111321, Colombia.

The aim of this study was to explore the potential of the agroindustrial waste from two Colombian mango cultivars as sources of bioactive phenolic compounds. Phenolic extracts from mango waste (peels, seed coats, and seed kernels) of 'sugar mango' and 'Tommy Atkins' cultivars were obtained. The bioactive properties of the phenolic extracts were accessed by measuring their free radical scavenging activity and antioxidant effects against lipid oxidation in food products; moreover, their antiproliferative effects against some cell lines of human cancer were explored. Read More

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http://dx.doi.org/10.3390/antiox8020041DOI Listing
February 2019

Leaf biochemical adjustments in two Mediterranean resprouter species facing enhanced UV levels and reduced water availability before and after aerial biomass removal.

Plant Physiol Biochem 2019 Feb 5;137:130-143. Epub 2019 Feb 5.

Department of Environmental Sciences, Faculty of Sciences, University of Girona, Campus Montilivi, C/ Maria Aurèlia Capmany i Farnés 69, E-17003, Girona, Spain.

Effects of supplemented UV radiation and diminished water supply on the leaf concentrations of phenols and antioxidants of two Mediterranean resprouter species, Arbutus unedo and Quercus suber, were assessed before and after entire aerial biomass removal. Potted seedlings of both species were grown outdoors for 8 months with enhanced UV-A + UV-B, enhanced UV-A or ambient UV, in combination with two watering conditions (field capacity or watering reduction). After this period, all aerial biomass was removed and new shoots (resprouts) developed for a further 8 months under the two treatments. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.01.031DOI Listing
February 2019

Rhein from Rheum rhabarbarum inhibits hydrogen peroxide-induced oxidative stress in intestinal epithelial cells partly through PI3K/Akt-mediated Nrf2/HO-1 pathways.

J Agric Food Chem 2019 Feb 19. Epub 2019 Feb 19.

Rheum rhabarbarum has been widely used as a herbal medicine and food in China. The objective of this study was to investigate the cytoprotective action and underlying mechanisms of rhein, one active ingredient isolated from Rheum rhabarbarum, on H2O2-challenged rat small intestine epithelial cells (IEC-6 cells). H2O2-challenged IEC-6 cells were incubated in the pretreatment with or without rhein or LY294002, a PI3K/Akt inhibitor. Read More

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http://dx.doi.org/10.1021/acs.jafc.9b00037DOI Listing
February 2019

Phytochemical characterization and biological activities of a hydroalcoholic extract obtained from the aerial parts of Matthiola incana (L.) R. Br. subsp. incana (Brassicaceae) growing wild in Sicily (Italy).

Chem Biodivers 2019 Feb 19. Epub 2019 Feb 19.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy, ITALY.

This study aimed to characterize the phenolic and the volatile constituents and to establish the antioxidant potential and the toxicity of a hydroalcoholic extract obtained from the leaves and flower buds of Matthiola incana (L.) R. Br. Read More

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http://dx.doi.org/10.1002/cbdv.201800677DOI Listing
February 2019

Peptides from Mucuna pruriens L., with protection and antioxidant in vitro effect on HeLa cell line.

J Sci Food Agric 2019 Feb 18. Epub 2019 Feb 18.

Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Periférico Norte Km. 33.5, Tablaje Catastral 13615, Col. Chuburná de Hidalgo Inn, 97203, Mérida, Yucatán, México.

Background: M. pruriens L. is a legume sown in the Mexican southeast with an important protein content. Read More

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http://doi.wiley.com/10.1002/jsfa.9649
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http://dx.doi.org/10.1002/jsfa.9649DOI Listing
February 2019
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Prospective Serum Metabolomic Profiling of Lethal Prostate Cancer.

Int J Cancer 2019 Feb 18. Epub 2019 Feb 18.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Impaired metabolism may play an important role in the pathogenesis of lethal prostate cancer, yet there is a paucity of evidence regarding the association. We conducted a large prospective serum metabolomic analysis of lethal prostate cancer in 523 cases and 523 matched controls nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Median time from baseline fasting serum collection to prostate cancer death was 18 years (maximum 30 years). Read More

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http://doi.wiley.com/10.1002/ijc.32218
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http://dx.doi.org/10.1002/ijc.32218DOI Listing
February 2019
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Role/s of 'Antioxidant' Enzymes in Ageing.

Subcell Biochem 2018 ;90:425-450

Institute for Cell and Molecular Biosciences and Institute for Ageing, Newcastle University, Tyne, UK.

Reactive oxygen species (ROS), generated externally and during aerobic metabolism, are a potent cause of cell damage. Oxidative damage is a feature of many diseases and ageing, including age-associated diseases, such as diabetes, cancer, cardiovascular and neurodegenerative diseases. Indeed, this association helped lead to the widely expounded 'Free Radical Theory of Aging', proposing that the accumulation of ROS-induced damage is the underlying cause of ageing. Read More

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http://dx.doi.org/10.1007/978-981-13-2835-0_14DOI Listing
January 2018

Antioxidant Vitamins and Ageing.

Subcell Biochem 2018 ;90:1-23

University of Ljubljana, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia.

The free radical theory of ageing (FRTA), presented by Denham Harman in 1950s, proposed that aerobic organisms age due to reactive oxygen species (ROS)/free radical induced damage that accumulates in cells over time. Since antioxidants can neutralize free radicals by electron donation, the most logical approach was to use them as supplements in order to prevent ageing. In this chapter, we will discuss the inability of antioxidant supplementation to improve health and longevity. Read More

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http://dx.doi.org/10.1007/978-981-13-2835-0_1DOI Listing
January 2018

Organ-specific responses to total ammonia nitrogen stress on juvenile grass carp (Ctenopharyngodon idellus).

Environ Sci Pollut Res Int 2019 Feb 18. Epub 2019 Feb 18.

College of Geography and Environment, Collaborative Innovation Center of Human-Nature and Green Development in Universities of Shandong, Shandong Normal University, Jinan, 250014, People's Republic of China.

Fish are important in constructed wetland (CW) ecosystem. An 80-day experiment was conducted by exposing juvenile grass carp (Ctenopharyngodon idellus) to 0, 0.5, 2. Read More

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http://dx.doi.org/10.1007/s11356-019-04524-4DOI Listing
February 2019

Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment.

Nat Nanotechnol 2019 Feb 18. Epub 2019 Feb 18.

Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China.

Mitochondrial redox homeostasis, the balance between reactive oxygen species and antioxidants such as glutathione, plays critical roles in many biological processes, including biosynthesis and apoptosis, and thus is a potential target for cancer treatment. Here, we report a mitochondrial oxidative stress amplifier, MitoCAT-g, which consists of carbon-dot-supported atomically dispersed gold (CAT-g) with further surface modifications of triphenylphosphine and cinnamaldehyde. We find that the MitoCAT-g particles specifically target mitochondria and deplete mitochondrial glutathione with atomic economy, thus amplifying the reactive oxygen species damage caused by cinnamaldehyde and finally leading to apoptosis in cancer cells. Read More

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http://dx.doi.org/10.1038/s41565-019-0373-6DOI Listing
February 2019

Hepatoprotective and antioxidant effects of Hedera helix extract on acetaminophen induced oxidative stress and hepatotoxicity in mice.

Biotech Histochem 2019 Feb 19:1-7. Epub 2019 Feb 19.

e Center for Research and Training in Skin Diseases and Leprosy , Tehran University of Medical Sciences , Tehran , Iran.

Exposure to high doses of acetaminophen is the most common cause of drug induced liver injury. We investigated the protective effects of Hedera helix extract against acetaminophen induced oxidative stress and hepatotoxicity using a mouse model. We used two control groups: group A was given 0. Read More

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http://dx.doi.org/10.1080/10520295.2019.1566569DOI Listing
February 2019

The potential of an energy crop "Conocarpus erectus" for lead phytoextraction and phytostabilization of chromium, nickel, and cadmium: An excellent option for the management of multi-metal contaminated soils.

Ecotoxicol Environ Saf 2019 Feb 15;173:273-284. Epub 2019 Feb 15.

Department of Environmental Sciences and Engineering, Government College University, Faisalabad, 38000, Pakistan. Electronic address:

Past studies have thoroughly explored the phytoextraction/phytostabilization potentials of different plant species for particular metals. However, none of the plants was able to tackle the problem of multi-metal in contaminated soils. We report herewith the potential of Conocarpus erectus to extract lead (Pb) while having the capability to stabilize chromium (Cr), nickel (Ni) and cadmium (Cd) in polluted soil. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.119DOI Listing
February 2019

Antioxidants and improved regrowth procedure facilitated cryoconservation of Paphiopedilum insigne Wall. Ex. Lindl. - An Endangered Slipper Orchid.

Cryobiology 2019 Feb 15. Epub 2019 Feb 15.

Plant Biotechnology Laboratory, Department of Botany, Centre for Advanced Studies, North-Eastern Hill University, Shillong, 793022, Meghalaya, India. Electronic address:

Orchids and their sustainability are very important issues that need global conservation efforts. Paphiopedilum insigne (an endangered orchid), is one of the most excessively exploited species of orchids and is mentioned in the IUCN Red List and Appendix I of CITES. The prospect for conservation and commercialization of this species would be strengthened with the development of improved cryopreservation techniques. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2019.02.003DOI Listing
February 2019

The effects of vitamin C and menthone on acyclovir induced DNA damage in rat spermatozoa: An experimental study.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):703-710

Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.

Background: Acyclovir (ACV) is known to be toxic to gonads, inducing apoptosis in the reproductive system. The beneficial effects of vitamin C (Vit C) and menthone, both as antioxidant agents on various organs has been reported.

Objective: This study evaluated the potential role of the Vit C and menthone on the DNA damage in rat spermatozoa induced by the ACV. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350846PMC
November 2018

Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?

Oxid Med Cell Longev 2019 15;2019:9109473. Epub 2019 Jan 15.

Department of Nephrology, Medical School, University of Ioannina, Ioannina, Greece.

The disruption of balance between production of reactive oxygen species and antioxidant systems in favor of the oxidants is termed oxidative stress (OS). To counteract the damaging effects of prooxidant free radicals, all aerobic organisms have antioxidant defense mechanisms that are aimed at neutralizing the circulating oxidants and repair the resulting injuries. Antioxidants are either endogenous (the natural defense mechanisms produced by the human body) or exogenous, found in supplements and foods. Read More

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http://dx.doi.org/10.1155/2019/9109473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350615PMC
January 2019

The effect of adding pomegranate seed extract to fat-containing diets on nutrients digestibility, intestinal microflora and growth performance of broilers.

Iran J Vet Res 2018 ;19(4):310-317

Graduated from College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran.

The present study was aimed at studying the effects of inclusion of pomegranate seed extract to fat-containing diets on nutrients digestibility, intestinal microflora and performance of broilers. A total of 320 one-day-old broiler chicks (Ross 308) were selected in a 2 × 2 × 2 factorial experiment in a completely randomized design with 4 replicates of 10 birds of each. The dietary treatments consisted of pomegranate seed extract (0 and 2%), commercial Nutriad antioxidant (0 and 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361599PMC
January 2018

Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis.

Diabetes Metab Syndr Obes 2019 23;12:171-180. Epub 2019 Jan 23.

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors.

Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Carib-bean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials. Read More

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https://www.dovepress.com/effect-of-kiwifruit-on-metabolic-h
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http://dx.doi.org/10.2147/DMSO.S193225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350646PMC
January 2019
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Depressed mood induction in early cigarette withdrawal is unaffected by acute monoamine precursor supplementation.

Neuropsychiatr Dis Treat 2019 23;15:311-321. Epub 2019 Jan 23.

CAMH Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada,

Background: Cigarette smoking is the leading preventable cause of death; however, quitting is difficult and early relapse is common. Dysphoric mood during early cigarette withdrawal is associated with relapse, and with the exception of bupropion and nortriptyline, few interventions have been developed to prevent this. During early cigarette withdrawal there is an elevation in the levels of monoamine oxidase-A (MAO-A), which removes monoamines excessively and induces oxidative stress and is implicated in creating sad mood. Read More

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http://dx.doi.org/10.2147/NDT.S172334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352866PMC
January 2019