514,399 results match your criteria Antioxidants & redox signaling[Journal]


High coenzyme Q10 plasma levels improve stress and damage markers in professional soccer players during competition.

Int J Vitam Nutr Res 2020 Jul 8:1-12. Epub 2020 Jul 8.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC-JA, and CIBERER, Instituto de Salud Carlos III, Sevilla, Spain.

Ubiquinol, the reduced form of Coenzyme Q (CoQ), is a key factor in bioenergetics and antioxidant protection. During competition, professional soccer players suffer from considerable physical stress causing high risk of muscle damage. For athletes, supplementation with several antioxidants, including CoQ, is widely recommended to avoid oxidative stress and muscle damage. Read More

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http://dx.doi.org/10.1024/0300-9831/a000659DOI Listing
July 2020
1.000 Impact Factor

Association between antioxidant vitamins and oxidative stress among patients with a complete hydatidiform mole.

Clinics (Sao Paulo) 2020 6;75:e1724. Epub 2020 Jul 6.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, New England Trophoblastic Disease Center, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA, USA.

Objectives: This study aimed to evaluate the potential relationship between oxidative stress, dietary intake, and serum levels of antioxidants in patients with a complete hydatidiform mole (CHM) compared with controls.

Methods: This was an observational cross-sectional study conducted in Rio de Janeiro, Brazil. A total of 140 women were enrolled in this study and divided into four groups: 43 patients with CHM, 33 women who had had an abortion, 32 healthy pregnant women, and 32 healthy non-pregnant women. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1724DOI Listing

Deficit schizophrenia and its features are associated with PON1 Q192R genotypes and lowered paraoxonase 1 (PON1) enzymatic activity: effects on bacterial translocation.

CNS Spectr 2020 Jun 23:1-10. Epub 2020 Jun 23.

Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil.

Background.: Primary deficit schizophrenia (DS) is characterized by enduring negative symptoms and represents a qualitatively different disease entity with respect to non-deficit schizophrenia (NDS). No studies investigated the association between the enzyme paraoxonase 1 (PON1) and DS and its phenomenology. Read More

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http://dx.doi.org/10.1017/S1092852920001388DOI Listing

Timing and Pattern of Anthocyanin Accumulation during Grain Filling in Purple Waxy Corn ( L.) Suggest Optimal Harvest Dates.

ACS Omega 2020 Jun 19;5(25):15702-15708. Epub 2020 Jun 19.

Department of Central Area Crop Science, National Institute of Crop Science, RDA, Suwon-si 16429, Republic of Korea.

Purple-corn kernels contain anthocyanins, a group of antioxidants proposed to be beneficial to human health. This study investigated the concentrations of anthocyanins and amino acids and the composition of fatty acids in the kernels of purple waxy corn ( L.) "Heukjinjuchal" during grain filling to determine when the grain nutritional value is at its highest. Read More

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http://dx.doi.org/10.1021/acsomega.0c02099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331206PMC

Avenanthramides as lipoxygenase inhibitors.

Heliyon 2020 Jun 29;6(6):e04304. Epub 2020 Jun 29.

Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties. There are various potential mechanisms for their anti-inflammatory effects, including inhibition of lipoxygenases (LOX), which catalyse oxygenation of polyunsaturated fatty acids into potent signal molecules involved in inflammatory processes. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330496PMC

The effects on oxidative aging, physical and flow properties of Agbabu natural bitumen modified with silver nanoparticles.

Heliyon 2020 Jun 27;6(6):e04164. Epub 2020 Jun 27.

Department of Pure and Applied Chemistry, Ladoke Akintola Universityof Technology, Ogbomoso, P.M.B. 4000, Nigeria.

The quest for improvement in service life and performance of road pavement via reduction of oxidative aging failure of bitumen, led us to the investigation of novel application of Silver nanoparticles (AgNPs) as potential anti-oxidative material for Agbabu natural bitumen (ANB). The raw ANB was purified to form the base and the base modified in a stainless reactor using AgNPs via melt blend technique at temperature of 120 °C under stirring at 1200rpm. The proportions of AgNPs used for the modification were 1. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327256PMC

Phytochemical Constituents, Antioxidant Activity, and Toxicity Assessment of the Seed of L. (Anacardiaceae).

Turk J Pharm Sci 2020 Jun 22;17(3):343-348. Epub 2020 Jun 22.

University of Ibadan College of Medicine, Department of Pharmacology and Therapeutics, Ibadan, Nigeria.

Objectives: Increased generation of free radicals exceeding the antioxidant capacity of the host is deleterious. Thus new, potent, and safe antioxidants will be a valuable addition to the limited antioxidant arsenals available. Therefore, the antioxidant activity, cytotoxicity potential, and phytochemical constituents of the methanol extract of seed (MESSM) were investigated. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2020.38801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336035PMC

Aspirin Induces Mitochondrial Ca Remodeling in Tumor Cells via ROS‒Depolarization‒Voltage-Gated Ca Entry.

Int J Mol Sci 2020 Jul 5;21(13). Epub 2020 Jul 5.

Plasma ChemiBio Laboratory, Nasushiobara, Tochigi 329-2813, Japan.

Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms. Depolarization of the plasma membrane potential leads to voltage-gated Ca entry (VGCE) and caspase-3 activation. In the present study, we investigated the role of depolarization and VGCE in aspirin's anti-melanoma effect. Read More

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http://dx.doi.org/10.3390/ijms21134771DOI Listing

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney.

Antioxidants (Basel) 2020 Jul 5;9(7). Epub 2020 Jul 5.

Institute of Toxicology, Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany.

In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS). With the help of knockout animals, the impact of the three predominant NADPH oxidases present in the kidney, i.e. Read More

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http://dx.doi.org/10.3390/antiox9070586DOI Listing

Phytoplankton Supplementation Lowers Muscle Damage and Sustains Performance across Repeated Exercise Bouts in Humans and Improves Antioxidant Capacity in a Mechanistic Animal.

Nutrients 2020 Jul 4;12(7). Epub 2020 Jul 4.

The Applied Science & Performance Institute, Research Division, Tampa, FL 33607, USA.

The purpose of this study was to investigate the impact of antioxidant-rich marine phytoplankton supplementation (Oceanix, OCX) on performance and muscle damage following a cross-training event in endurance-trained subjects. Additionally, an animal model was carried out to assess the effects of varying dosages of OCX, with exercise, on intramuscular antioxidant capacity.

Methods: In the human trial, endurance-trained subjects (average running distance = 29. Read More

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http://dx.doi.org/10.3390/nu12071990DOI Listing

Protective Effects of SPA0355, a Thiourea Analogue, Against Lipopolysaccharide-Induced Acute Kidney Injury in Mice.

Antioxidants (Basel) 2020 Jul 4;9(7). Epub 2020 Jul 4.

Department of Internal Medicine, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.

Inflammation and oxidative stress plays an essential role in the pathophysiology of sepsis-associated acute kidney injury (AKI). SPA0355, a thiourea analogue, has been shown to display beneficial effects against a variety of inflammatory diseases arising from its anti-inflammatory and anti-oxidant properties. However, the potential protective effects of SPA0355 against lipopolysaccharide (LPS)-induced AKI have not been explored. Read More

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http://dx.doi.org/10.3390/antiox9070585DOI Listing

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Molecules 2020 Jul 4;25(13). Epub 2020 Jul 4.

Department of Bioenergetics, Faculty of Biology, Adam Mickiewicz University, Poznan, Uniwersytetu Poznanskiego 6, 61-614 Poznan, Poland.

A large number of diverse mechanisms that lead to cytoprotection have been described to date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In addition to being metabolic centers, due to their role in cell catabolism, ATP synthesis, and biosynthesis these organelles are triggers and/or end-effectors of a large number of signaling pathways. Read More

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http://dx.doi.org/10.3390/molecules25133060DOI Listing

Microorganisms and Biostimulants Impact on the Antioxidant Activity of Buckwheat ( Moench) Sprouts.

Antioxidants (Basel) 2020 Jul 4;9(7). Epub 2020 Jul 4.

Department of Pharmacognosy, Medical College, Jagiellonian University, Medyczna 9, 30688 Krakow, Poland.

The study analyzes the influence of plant growth promoters and biological control agents on the chemical composition and antioxidant activity (AA) in the sprouts of buckwheat. The AA of cv. Kora sprouts was higher than cv. Read More

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http://dx.doi.org/10.3390/antiox9070584DOI Listing

Control of Reactive Oxygen Species for the Prevention of Parkinson's Disease: The Possible Application of Flavonoids.

Antioxidants (Basel) 2020 Jul 3;9(7). Epub 2020 Jul 3.

School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea.

Oxidative stress reflects an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and progression of neurodegenerative diseases such as multiple sclerosis, stroke, and Parkinson's disease (PD). The application of antioxidants, which can defend against oxidative stress, is able to detoxify the reactive intermediates and prevent neurodegeneration resulting from excessive ROS production. There are many reports showing that numerous flavonoids, a large group of natural phenolic compounds, can act as antioxidants and the application of flavonoids has beneficial effects in the adult brain. Read More

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http://dx.doi.org/10.3390/antiox9070583DOI Listing

Supplementation of 17β-Estradiol Normalizes Rapid Gastric Emptying by Restoring Impaired Nrf2 and nNOS Function in Obesity-Induced Diabetic Ovariectomized Mice.

Antioxidants (Basel) 2020 Jul 3;9(7). Epub 2020 Jul 3.

Department of ODS & Research, School of Dentistry, Nashville, TN 37208, USA.

Gastroparesis (Gp) is a multifactorial condition commonly observed in females and is characterized by delayed or rapid gastric emptying (GE). The role of ovarian hormones on GE in the pathogenesis of obesity induced type 2 diabetes mellitus (T2DM) is completely unknown. The aims of our study are to investigate whether supplementation of 17β-estradiol (E) or progesterone (P) restores impaired nuclear factor erythroid 2-related factor 2 (Nrf2, an oxidative stress-responsive transcription factor) and nitric oxide (NO)-mediated gastric motility in ovariectomized (OVX) mice consuming a high-fat diet (HFD, a model of T2DM). Read More

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http://dx.doi.org/10.3390/antiox9070582DOI Listing

An Innovative Olive Pâté with Nutraceutical Properties.

Antioxidants (Basel) 2020 Jul 3;9(7). Epub 2020 Jul 3.

Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli "Federico II", 80137 Napoli, Italy.

Food plays a central role in health, especially through consumption of plant-derived foods. Functional foods, supplements, and nutraceuticals are increasingly entering the market to respond to consumer demand for healthy products. They are foods, supplements, and ingredients which offer health benefits beyond the standard nutritional value. Read More

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http://dx.doi.org/10.3390/antiox9070581DOI Listing

Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish () Model.

Antioxidants (Basel) 2020 Jul 3;9(7). Epub 2020 Jul 3.

Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania.

Rhoifolin (Rho) exerts many biological activities such as anticancer, antidiabetic, hepatoprotective, antirheumatic, antibacterial, and antiviral properties. The neuroprotective action of this compound has not been studied. The goal of this study was to investigate the improvement impact of Rho on scopolamine (Sco)-induced zebrafish anxiety, amnesia, and brain oxidative stress and to elucidate the underlying mechanisms involved. Read More

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http://dx.doi.org/10.3390/antiox9070580DOI Listing

Reduced graphene oxide mitigates cadmium-induced cytotoxicity and oxidative stress in HepG2 cells.

Food Chem Toxicol 2020 Jul 4:111515. Epub 2020 Jul 4.

King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, 11451, Saudi Arabia; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Numerous applications of reduced graphene oxide (RGO) and pervasive cadmium (Cd) have led concern about their co-exposure to the environment and human. We studied the combined effects of RGO and Cd in human liver (HepG2) cells. Initially, we found that RGO (up to 50 μg/ml) did not harm to HepG2 cells while Cd induced dose-dependent (1-10 μg/ml) cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111515DOI Listing

Valorisation of Persimmon and Blueberry By-Products to Obtain Functional Powders: Digestion and Fermentation by Gut Microbiota.

J Agric Food Chem 2020 Jul 7. Epub 2020 Jul 7.

Globalization of fruit and vegetable market generates overproduction, surpluses and potentially valuable residues. The valorisation of these by-products constitutes a challenge, to ensure sustainability and reintroduce them into the food chain. This work focuses on blueberry and persimmon residues, rich in polyphenols and carotenoids, to obtain powders with high added value to be used as ingredients in food formulation. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c02088DOI Listing

The chemistry of chlorogenic acid from green coffee and its role in attenuation of obesity and diabetes.

Prep Biochem Biotechnol 2020 Jul 7:1-10. Epub 2020 Jul 7.

Spice and Flavor Science Department, CSIR-Central Food Technological research Institute, Mysuru, Karnataka, India.

An overview of green coffee, the unroasted bean enriched with antioxidants, is presented in the following article. Green coffee beans are known to have a higher content of chlorogenic acid (CGA) with potential health benefits like activity against hypertension, diabetes, obesity, etc. There are three major classes of chlorogenic acids present in green coffee beans, namely: caffeoylquinic acid (CQA), di-caffeoylquinic acid (diCQA) and feruloylquinic acid (FQA). Read More

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http://dx.doi.org/10.1080/10826068.2020.1786699DOI Listing

Gold nanoparticles phytoreduced with Cornus mas extract mitigate some of gliadin effects on Caco-2 cells.

J Physiol Pharmacol 2020 Apr 2;71(2). Epub 2020 Jul 2.

Department of Gastroenterology and Hepatology, Regional Institute of Gastroenterology and Hepatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Celiac disease (CD) is an autoimmune condition that occurs in genetically predisposed people where the ingestion of gluten produces damage in the small intestine. The treatment accepted until now is a strict gluten free diet. This implies the need for novel or adjuvant treatments, in addition to the standard of care. Read More

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http://dx.doi.org/10.26402/jpp.2020.2.04DOI Listing

Vitamin C inhibits glycidamide-induced genotoxicity and apoptosis in Sertoli cells.

J Biochem Mol Toxicol 2020 Jul 7:e22545. Epub 2020 Jul 7.

Department of Biology, Faculty of Sciences, Istanbul University, Istanbul, Turkey.

Exposure to the food contaminant acrylamide and its reactive epoxide metabolite glycidamide (GA) induces reactive oxygen species (ROS)-mediated oxidative stress and subsequent cellular death. Recent studies have revealed that the toxic effects of acrylamide may be due to GA, especially on male reproductive system cells. In this regard, it is important to determine the effects of GA on Sertoli cells, which are essential cells for the male reproductive system. Read More

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http://dx.doi.org/10.1002/jbt.22545DOI Listing

Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention.

Toxicol Rep 2020 18;7:768-771. Epub 2020 Jun 18.

Ultimovacs AB, Uppsala Sweden.

During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. Hereby, based on literature review from the current pandemic and previous outbreaks with corona viruses we analyze the impact of the virus infection on cell stress responses and redox balance. High levels of mortality are noticed in elderly individuals infected with SARS-CoV2 and during the previous SARS-CoV1 outbreak. Read More

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http://dx.doi.org/10.1016/j.toxrep.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301821PMC

IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.

Br J Cancer 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, China.

Background: Hepatitis B virus (HBV) has a crucial role in the progression of hepatocellular carcinoma (HCC). Tumour cells must develop anoikis resistance in order to survive before metastasis. This study aimed to investigate the mechanism of IQGAP1 in HBV-mediated anoikis evasion and metastasis in HCC cells. Read More

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http://dx.doi.org/10.1038/s41416-020-0970-zDOI Listing
July 2020
4.836 Impact Factor

TIGAR/AP-1 axis accelerates the division of Lgr5 reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation.

Cell Death Dis 2020 Jul 6;11(7):501. Epub 2020 Jul 6.

Institute of Radiation Medicine, Fudan University, Shanghai, 200032, China.

During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve intestinal stem cells (ISCs) and secretory progenitor cells are both reported to replenish damaged cells and contribute to crypt regeneration. Read More

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http://dx.doi.org/10.1038/s41419-020-2715-6DOI Listing

Serum antioxidant micronutrient levels in pre-eclamptic pregnant women in Enugu, south-East Nigeria: a comparative cross-sectional analytical study.

BMC Pregnancy Childbirth 2020 Jul 6;20(1):392. Epub 2020 Jul 6.

Departments of Obstetrics and Gynaecology, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.

Background: Pre-eclampsia is a common obstetric complication of pregnancy in Nigeria, and oxidative stress has been implicated in its aetiopathogenesis. Despite this fact, there is a paucity of information regarding the serum antioxidant micronutrient status of pre-eclamptic Nigerian women. The objective of the was to determine the mean serum levels of some antioxidant trace elements (copper, zinc, selenium, magnesium, manganese) in pre-eclamptic pregnant women and compare with that of healthy pregnant women in Enugu, South-Eastern, Nigeria. Read More

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http://dx.doi.org/10.1186/s12884-020-03081-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339396PMC

Insights into Arbutin Effects on Bone Cells: Towards the Development of Antioxidant Titanium Implants.

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Department of Chemistry, University of Bari Aldo Moro, 70126 Bari, Italy.

Arbutin is a plant-derived glycosylated hydroquinone with antioxidant features, exploited to combat cell damage induced by oxidative stress. The latter hinders the osseointegration of bone prostheses, leading to implant failure. Little is known about arbutin antioxidant effects on human osteoblasts, therefore, this study explores the in vitro protective role of arbutin on osteoblast-like cells (Saos-2) and periosteum-derived progenitor cells (PDPCs). Read More

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http://dx.doi.org/10.3390/antiox9070579DOI Listing

Serum Malondialdehyde is Associated with Non-Alcoholic Fatty Liver and Related Liver Damage Differentially in Men and Women.

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Institute of Biochemistry, Food Science and Nutrition, The RH Smit Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rechovot 76100001, Israel.

Background: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are associated with increased oxidative stress and lipid peroxidation, but large studies are lacking. The aim was to test the association of malondialdehyde (MDA), as a marker of oxidative damage of lipids, with NAFLD and liver damage markers, and to test the association between dietary vitamins E and C intake and MDA levels.

Methods: A cross-sectional study was carried out among subjects who underwent blood tests including FibroMax for non-invasive assessment of NASH and fibrosis. Read More

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http://dx.doi.org/10.3390/antiox9070578DOI Listing

Enrichment in Antioxidant Flavonoids of Stamen Extracts from L. Using Ultrasonic-Assisted Extraction and Macroporous Resin Adsorption.

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Laboratoire de Biologie des Ligneux et des Grandes Cultures, INRA USC1328, University of Orleans, CEDEX 2, 45067 Orléans, France.

Nymphaea lotus L. is the medicinal plant that has long been used for food, cosmetics and traditional medicines in Africa and Asia since ancient times. Its flavonoids and other interesting phytochemical compounds from rhizome, leaf and the whole flowers have been reported in the previous published research. Read More

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http://dx.doi.org/10.3390/antiox9070576DOI Listing

Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch?

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Laboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.

Huntington disease (HD) is a neurodegenerative condition and one of the so-called rare or minority diseases, due to its low prevalence (affecting 1-10 of every 100,000 people in western countries). The causative gene, , encodes huntingtin, a protein with a yet unknown function. Mutant huntingtin causes a range of phenotypes, including oxidative stress and the activation of microglia and astrocytes, which leads to chronic inflammation of the brain. Read More

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http://dx.doi.org/10.3390/antiox9070577DOI Listing

A Potent Lignan from Prunes Alleviates Inflammation and Oxidative Stress in Lithium/Pilocarpine-Induced Epileptic Seizures in Rats.

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.

L. is an edible plant that is included in the family Rosaceae and proven to possess potent anti-inflammatory and anxiolytic activity. Pinoresinol-4---d-glucopyranoside (PGu) was isolated from methanol extract and its structure was determined using 1-D and 2-D NMR (one- and two-dimensional nuclear magnetic resonance). Read More

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http://dx.doi.org/10.3390/antiox9070575DOI Listing

Regulatory Effect of Bmb6 on Gut Barrier Functions in Experimental Colitis.

Foods 2020 Jul 2;9(7). Epub 2020 Jul 2.

Division of Animal Science, Chonnam National University, Gwangju 61186, Korea.

The integrity of gut barrier functions is closely associated with the pathogenesis of colitis. It is speculated that Bmb6 alleviates colitis by improving the tight junction (TJ) of the inflamed intestinal epithelial layer. In the present study, the regulatory effects of Bmb6 on the TJ barrier to ameliorate colitis-symptoms were investigated. Read More

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http://dx.doi.org/10.3390/foods9070864DOI Listing

Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications.

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.

Perivascular adipose tissue (PVAT) is the connective tissue surrounding most of the systemic blood vessels. PVAT is now recognized as an important endocrine tissue that maintains vascular homeostasis. Healthy PVAT has anticontractile, anti-inflammatory, and antioxidative roles. Read More

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http://dx.doi.org/10.3390/antiox9070574DOI Listing

Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition.

Antioxidants (Basel) 2020 Jul 2;9(7). Epub 2020 Jul 2.

Diabète athérothrombose Thérapies Réunion Océan Indien, INSERM, UMR 1188, Université de La Réunion, 2 rue Maxime Rivière, 97490 Sainte-Clotilde, La Réunion, France.

Blood-brain barrier endothelial cells are the main targets of diabetes-related hyperglycemia that alters endothelial functions and brain homeostasis. Hyperglycemia-mediated oxidative stress may play a causal role. This study evaluated the protective effects of characterized polyphenol-rich medicinal plant extracts on redox, inflammatory and vasoactive markers on murine bEnd3 cerebral endothelial cells exposed to high glucose concentration. Read More

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http://dx.doi.org/10.3390/antiox9070573DOI Listing

Ethylene: A Master Regulator of Salinity Stress Tolerance in Plants.

Biomolecules 2020 Jun 25;10(6). Epub 2020 Jun 25.

Department of Botany, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India.

Salinity stress is one of the major threats to agricultural productivity across the globe. Research in the past three decades, therefore, has focused on analyzing the effects of salinity stress on the plants. Evidence gathered over the years supports the role of ethylene as a key regulator of salinity stress tolerance in plants. Read More

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http://dx.doi.org/10.3390/biom10060959DOI Listing

In vitro Antioxidant, Anti-inflammatory, Anti-metabolic Syndrome, Antimicrobial, and Anticancer Effect of Phenolic Acids Isolated from Fresh Lovage Leaves [ Koch] Elicited with Jasmonic Acid and Yeast Extract.

Antioxidants (Basel) 2020 Jun 25;9(6). Epub 2020 Jun 25.

Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology Kozielska 4, 01-163 Warsaw, Poland.

Lovage seedlings were elicited with jasmonic acid (JA) and yeast extract (YE) to induce the synthesis of biologically active compounds. A simulated digestion process was carried out to determine the potential bioavailability of phenolic acids. Buffer extracts were prepared for comparison. Read More

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http://dx.doi.org/10.3390/antiox9060554DOI Listing

ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.

Antioxidants (Basel) 2020 Jun 25;9(6). Epub 2020 Jun 25.

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

This study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer's disease risk. Starting at 12 months of age, separate groups of male and female mice expressing human Apolipoprotein E3 (GFAP-ApoE3) or E4 (GFAP-ApoE4) were fed either a control diet or a diet supplemented with vitamins E and C. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. Read More

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http://dx.doi.org/10.3390/antiox9060553DOI Listing

An Artificial Intelligence Approach for Italian EVOO Origin Traceability through an Open Source IoT Spectrometer.

Foods 2020 Jun 25;9(6). Epub 2020 Jun 25.

Consiglio per la Ricerca in Agricoltura e l'analisi dell'economia Agraria (CREA)-Centro di Ricerca Ingegneria e Trasformazioni Agroalimentari, Via della Pascolare 16, 00015 Monterotondo (Rome), Italy.

Extra virgin olive oil (EVOO) represents a crucial ingredient of the Mediterranean diet. Being a first-choice product, consumers should be guaranteed its quality and geographical origin, justifying the high purchasing cost. For this reason, it is important to have new reliable tools able to classify products according to their geographical origin. Read More

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http://dx.doi.org/10.3390/foods9060834DOI Listing

Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria.

Antioxidants (Basel) 2020 Jun 25;9(6). Epub 2020 Jun 25.

Department of Applied Physics, Aalto University, 00076 Espoo, Finland.

Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. Historically, willow ( sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Read More

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http://dx.doi.org/10.3390/antiox9060552DOI Listing

Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells.

Antioxidants (Basel) 2020 Jun 25;9(6). Epub 2020 Jun 25.

Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.

Oxidative stress (OS) appears to be an important determinant during the different stages of progression of Alzheimer's Disease (AD). In particular, impaired antioxidant defense mechanisms, such as the decrease of glutathione (GSH) and nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), a master regulator of antioxidant genes, including those for GSH, are associated with OS in the human AD brain. Among the neuropathological hallmarks of AD, the soluble oligomers of amyloid beta (A) peptides seem to promote neuronal death through mitochondrial dysfunction and OS. Read More

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http://dx.doi.org/10.3390/antiox9060551DOI Listing

Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing.

Nanomaterials (Basel) 2020 Jun 25;10(6). Epub 2020 Jun 25.

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.

Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Read More

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http://dx.doi.org/10.3390/nano10061234DOI Listing

Polyphenols Attenuate Highly-Glycosylated Haemoglobin-Induced Damage in Human Peritoneal Mesothelial Cells.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Genomic and Molecular Nephropathy Sections, Instituto de Genética Médica y Molecular (INGEMM), IdiPaz-Hospital Universitario La Paz, y Centro de Investigación Básica en Red de Enfermedades Raras (CIBERER), 28046 Madrid, Spain.

We investigated the cytoprotective role of the dietary polyphenols on putative damage induced by Amadori adducts in Human Peritoneal Mesothelial Cells (HPMCs). Increased accumulation of early products of non-enzymatic protein glycation-Amadori adducts-in the peritoneal dialysis fluid due to their high glucose, induces severe damage in mesothelial cells during peritoneal dialysis. Dietary polyphenols reportedly have numerous health benefits in various diseases and have been used as an efficient antioxidant in the context of several oxidative stress-related pathologies. Read More

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http://dx.doi.org/10.3390/antiox9070572DOI Listing

Changes in Oxidative Stress, Inflammation, and Muscle Damage Markers Following Diet and Beetroot Juice Supplementation in Elite Fencers.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Nofer Institute of Occupational Medicine, Department of Biological and Environmental Monitoring, Sw. Teresy 8, 91-348 Łódź, Poland.

The aim of this study was to assess the impact of diet and active substances in beetroot juice on the parameters of oxidative stress, inflammation, and muscle damage as well as on the maximum rate of oxygen uptake (VO) in elite fencers (10 women, 10 men). Athletes during four weeks realized dietary recommendations (ID) and, after that, diet with freeze-dried beetroot juice supplementation (ID&BEET). At baseline and after each stage, fasting antioxidants, biomarkers of oxidative stress, inflammation, and skeletal muscle damage were measured, and a VO test was performed. Read More

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http://dx.doi.org/10.3390/antiox9070571DOI Listing

Dietary Antioxidants and Parkinson's Disease.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Department of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA.

Parkinson's disease (PD) is a neurodegenerative disorder caused by the depletion of dopaminergic neurons in the basal ganglia, the movement center of the brain. Approximately 60,000 people are diagnosed with PD in the United States each year. Although the direct cause of PD can vary, accumulation of oxidative stress-induced neuronal damage due to increased production of reactive oxygen species (ROS) or impaired intracellular antioxidant defenses invariably occurs at the cellular levels. Read More

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http://dx.doi.org/10.3390/antiox9070570DOI Listing

The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-based Analysis.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Center for Cardio-Metabolic Research in Africa (CARMA), Department of Physiological Sciences, Stellenbosch University, Stellenbosch 7600, South Africa.

Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (~200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Read More

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http://dx.doi.org/10.3390/antiox9070569DOI Listing

Innovative and Conventional Valorizations of Grape Seeds from Winery By-Products as Sustainable Source of Lipophilic Antioxidants.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Faculty of Technology, University of Novi Sad, Blvd. cara Lazara 1, 21000 Novi Sad, Serbia.

The aim of this study was to valorize the oil recovery from red and white grape seeds ( L.) that remains as by-product after the winemaking process. Oils were extracted by modern techniques, ultrasound assisted (UAE), microwave assisted (MAE) and supercritical fluid extraction (SFE), and compared to the Soxhlet extraction (SE). Read More

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http://dx.doi.org/10.3390/antiox9070568DOI Listing

Antioxidant Activity Modulated by Polyphenol Contents in Apple and Leaves during Fruit Development and Ripening.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, 37 Chełmońskiego Str., 51-630 Wrocław, Poland.

Apples ( Borkh) are of particular interest for their high content of healthy phytochemicals. This study investigated the antioxidant activity and polyphenolic compounds of extracts from the fruits from Ozark Gold, Starkinson and Kosztela cultivars and additionally leaves from Ozark Gold cv. Phenolic compounds were identified and quantified by liquid chromatography- mass spectrometer (LC-MS) and high pressure liquid chromatography (HPLC). Read More

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http://dx.doi.org/10.3390/antiox9070567DOI Listing

() and () Genes Influence on Semolina Yellowness in Wheat Mediterranean Germplasm.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Departamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago 306-22, Chile.

() and (-1) are key genes involved in the synthesis and catalysis of carotenoid pigments in durum wheat, regulating the increase and decrease in these compounds, respectively, resulting in the distinct yellow color of semolina and pasta. Here, we reported new haplotype variants and/or allele combinations of these two genes significantly affecting yellow pigment content in grain and semolina through their effect on carotenoid pigments. To reach the purpose of this work, three complementary approaches were undertaken: the identification of QTLs associated to carotenoid content on a recombinant inbred line (RIL) population, the characterization of a Mediterranean panel of accessions for and genes, and monitoring the expression of and genes during grain filling on two genotypes with contrasting yellow pigments. Read More

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http://dx.doi.org/10.3390/ijms21134669DOI Listing

NRF2 Knockdown Resensitizes 5-Fluorouracil-Resistant Pancreatic Cancer Cells by Suppressing HO-1 and ABCG2 Expression.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Division of Gastroenterology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.

Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic cancer and remains an obstacle to successful treatment. The antioxidant transcription factor nuclear factor (erythroid-derived 2)-related factor 2 (NRF2), which plays important roles in tumor angiogenesis and invasiveness, is upregulated in pancreatic ductal adenocarcinoma (PDAC), where it correlates with poor survival. Here, we investigated the role of NRF2 in two 5-Fluourouracil-resistant (5-FUR) PDAC cell lines: BxPC-3 and CFPAC-1. Read More

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http://dx.doi.org/10.3390/ijms21134646DOI Listing

Laminarin Attenuates Ultraviolet-Induced Skin Damage by Reducing Superoxide Anion Levels and Increasing Endogenous Antioxidants in the Dorsal Skin of Mice.

Mar Drugs 2020 Jun 30;18(7). Epub 2020 Jun 30.

Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Korea.

A number of studies have demonstrated that marine carbohydrates display anti-oxidant, anti-melanogenic, and anti-aging activities in the skin. Laminarin (LA), a low-molecular-weight polysaccharide, is found in brown algae. The benefits of LA in ultraviolet B (UVB) induced photodamage of the skin have not been reported. Read More

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http://dx.doi.org/10.3390/md18070345DOI Listing
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