488,196 results match your criteria Antioxidants & redox signaling[Journal]


Revelation of microalgae's lipid production and resistance mechanism to ultra-high Cd stress by integrated transcriptome and physiochemical analyses.

Environ Pollut 2019 Apr 8;250:186-195. Epub 2019 Apr 8.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. Electronic address:

The ultra-high Cd polluted environment is a special habitat in nature. Analysis of the biological adaptation and resistance mechanism of Auxenochlorella protothecoides UTEX234 to ultra-high Cd stress would offer some inspiring understanding on Cd detoxification mechanism and help discovering highly active bioremediation agents. In this study, integrated analyses of the transcriptome, multi-physiological and biochemical data and fatty acid profilings of UTEX2341 were performed for the first time. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.018DOI Listing

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1566-1570

Visual Function Core, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States.

Purpose: To test the hypothesis that oxidative stress in the outer retina (OR = distance from external limiting membrane to the retinal pigment epithelium-choroid boundary) can be detected by using antioxidants (AOs) to correct an impaired light-evoked response as measured by optical coherence tomography (OCT).

Methods: C57BL/6J mice were maintained in the dark for ∼20 hours and studied by OCT before and after 1 hour of light exposure. OR thickness in dark or light was measured, and the light-dark difference (i. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.18-26164DOI Listing
April 2019
1 Read

Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants.

ACS Appl Mater Interfaces 2019 Apr 17. Epub 2019 Apr 17.

Graphene quantum dots (GQDs) have recently been employed in various fields including medicine as antioxidants, primarily due to favorable biocompatibility in comparison to common inorganic quantum dots, although the structural features that lead to the biological activities of GQDs are poorly understood. Here we report that coal derived GQDs and their poly(ethylene glycol)-functionalized derivatives serve as efficient antioxidants, and we evaluate their electrochemical, chemical, and in vitro biological activity. Through the evaluation of scavenging abilities toward reactive oxygen species, we demonstrate correlation of π-conjugated stable radicals with activity. Read More

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http://dx.doi.org/10.1021/acsami.9b01082DOI Listing

Alpha-linolenic acid ameliorates bronchial asthma features in ovalbumin-sensitized rats.

J Pharm Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Effect of alpha-linolenic acid (ALA) against ovalbumin (OVA)-induced inflammation, oxidant/antioxidant imbalance and pathological features was examined in rat.

Methods: Total and differential WBC count and oxidant/antioxidant levels in BALF (bronchoalveolar lavage fluid) as well as lung pathological features were investigated in five groups of rats including controls (group C), rats sensitized with OVA (group S) and S treated with either ALA (0.2 and 0. Read More

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http://dx.doi.org/10.1111/jphp.13094DOI Listing

Inflammation, Antipsychotic Drugs, and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia.

Curr Top Behav Neurosci 2019 Apr 17. Epub 2019 Apr 17.

School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

In recent years, there is a new optimism in schizophrenia therapeutics with the emergence of immunomodulation as a potential treatment approach. Current evidence points to various immunological abnormalities in schizophrenia, including cell-mediated processes, acute phase proteins, cytokines, and intracellular mediators. Trait- and state-related immune dysfunction appears to exist, and a strong case can therefore be made for immunomodulation therapies in the prevention, treatment, and/or moderating the course of schizophrenia. Read More

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http://dx.doi.org/10.1007/7854_2019_91DOI Listing

Maturation trade-offs in octopus females and their progeny: energy, digestion and defence indicators.

PeerJ 2019 9;7:e6618. Epub 2019 Apr 9.

Laboratorio Nacional de Resiliencia Costera (LANRESC), UNAM-CONACYT, Sisal, Yucatán, Mexico.

Sexual maturation and reproduction influence the status of a number of physiological processes and consequently the ecology and behaviour of cephalopods. Using as a study model, the present work was focused in the changes in biochemical compound and activity that take place during gonadal maturation of females and its consequences in embryo and hatchlings characteristics. To do that, a total of 31 adult females of were sampled to follow metabolites (ovaries and digestive gland) and digestive enzyme activities (alkaline and acidic proteases) during physiological and functional maturation. Read More

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http://dx.doi.org/10.7717/peerj.6618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461028PMC

The Effect of Taxifolin on Cisplatin-Induced Pulmonary Damage in Rats: A Biochemical and Histopathological Evaluation.

Mediators Inflamm 2019 12;2019:3740867. Epub 2019 Mar 12.

Department of Nursing, Faculty of Health Sciences, Erzincan Binali Yildirim University, Erzincan, Turkey.

The effect of taxifolin on cisplatin-induced oxidative pulmonary damage was investigated biochemically and histopathologically in male albino Wistar rats. There were four groups, with six animals in each group: 50 mg/kg of taxifolin plus 2.5 mg/kg of cisplatin (TC) group, 2. Read More

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http://dx.doi.org/10.1155/2019/3740867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434269PMC

Inhibition of Advanced Glycation End-Product Formation by High Antioxidant-Leveled Spices Commonly Used in European Cuisine.

Antioxidants (Basel) 2019 Apr 15;8(4). Epub 2019 Apr 15.

Department of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.

Spices and herbs, as good sources of polyphenols, could be strong inhibitors of advanced glycation end-product (AGE) formation. The aim of this research was to measure the ability of various spices to inhibit AGEs and to study the correlation of AGE inhibition with total phenolic (TP) content and antioxidant capacity. Fourteen spices commonly used in European cuisine were extracted with a 50% ethanol solution, and their water and total phenolic contents and antioxidant capacities were examined. Read More

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http://dx.doi.org/10.3390/antiox8040100DOI Listing

Addition of Sesamol Increases the Oxidative Stability of Beeswax Organogels and Beef Tallow Matrix Under UV Light Irradiation and Thermal Oxidation.

J Food Sci 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Food Science and Biotechnology and Food Flavor Sensory Research Center, Sungkyunkwan Univ., Suwon, Republic of Korea.

To enhance the oxidative stability of organogels made from canola oil, 40 ppm sesamol was added to beeswax-based organogels stored under ultraviolet (UV) light irradiation and 60 or 100 °C thermal oxidation conditions. To study the practical application of organogels as animal fat substitutes, beef tallow was mixed with organogels and their oxidative stability was determined under oxidative stress conditions. Without sesamol addition, the organogels and beef tallow with organogel oxidized rapidly under UV irradiation and thermal oxidation. Read More

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http://dx.doi.org/10.1111/1750-3841.14590DOI Listing
April 2019
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[Protective effects of flavonoids from Gynostemma pentaphyllum on oxidative damage in LLC-PK1 cells].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1193-1200

School of Pharmacy,Minzu University of China Beijing 100081,China.

Four flavonoids were isolated from Gynostemma pentaphyllum by chromatography methods and their structures were identified by MS and NMR spectra data as quercetin-3-O-( 2″,6″-di-α-L-rhamnosyl)-β-D-galactopyranoside( 1),quercetin-3-O-( 2″,6″-di-α-L-rhamnosyl)-β-D-glucopyranoside( 2),quercetin-3-O-( 2″-α-L-rhamnosyl)-β-D-galactopyranoside( 3),and quercetin-3-O-( 2″-α-L-rhamnosyl)-β-D-glucopyranoside( 4). Among them,compounds 1-3 were obtained from the Cucurbitaceae family for the first time.The four flavonoids showed potent antioxidant effects against the DPPH,·OH and ■radicals in vitro,especially for DPPH radical scavenging activity with the IC50 values of 71. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181226.019DOI Listing

Toxicological effects of toxic metals (cadmium and mercury) on blood and the thyroid gland and pharmacological intervention by vitamin C in rabbits.

Environ Sci Pollut Res Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Zoology, University of the Punjab, Lahore, Pakistan.

Cadmium and mercury are non-biodegradable toxic metals that may cause many detrimental effects to the thyroid gland and blood. Vitamin C has been found to be a significant chain-breaking antioxidant and enzyme co-factor against metal toxicity and thus make them less available for animals. The current study was performed to find the effect of individual metals (cadmium and mercury), their co-administration, and the ameliorative effects of vitamin C on some of the parameters that indicate oxidative stress and thyroid dysfunction. Read More

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http://dx.doi.org/10.1007/s11356-019-04886-9DOI Listing

Herbal feed additives containing essential oil: 1. Impact on the nutritional worth of complete feed in vitro.

Trop Anim Health Prod 2019 Apr 15. Epub 2019 Apr 15.

Department of Animal Nutrition, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, 141004, India.

This study was taken up to assess the impact of supplementing herbal feed additives [HFAs; fruit of Myristica fragrans (Jayphall), seeds of Anethum sowa (Suva), fruit of Apium graveolens (Ajmo), fruit of Cuminum cyminum (Jeera), bark of Cinnamonum zeylanicum (Dalchini), or whole plant of Eclipta alba (Bhangro)] containing essential oils as active component on the nutrient utilization and methane production using wheat straw-based total mixed ration (TMR) as a substrate by in vitro gas production technique. The essential oil content was the highest (P < 0.01) in M. Read More

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http://dx.doi.org/10.1007/s11250-019-01887-1DOI Listing

High Dose Pomegranate Extract Suppresses Neutrophil Myeloperoxidase and Induces Oxidative Stress in a Rat Model of Sepsis.

Int J Vitam Nutr Res 2019 Apr 16:1-14. Epub 2019 Apr 16.

6 Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Introduction: The effect of using high dose pomegranate extract on sepsis and its safety is not clarified. Considering the fact that proper immune and inflammatory responses are needed to cope with infection, the aim of current study was to assess the effect of high dose pomegranate extract consumption on oxidative and inflammatory responses after disease induction in rat model of sepsis.

Methods: Sepsis was induced by Cecal Ligation and Perforation (CLP) surgery. Read More

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http://dx.doi.org/10.1024/0300-9831/a000563DOI Listing

Tuning the Transdermal Delivery of Hydroquinone upon Formulation with Novel Permeation Enhancers.

Pharmaceutics 2019 Apr 4;11(4). Epub 2019 Apr 4.

Department of Pharmaceutics and Food Technology, School of Pharmacy, Complutense University of Madrid, Ramón y Cajal square, 28040 Madrid, Spain.

Hydroquinone (HQ) is an anti-hyperpigmentation agent with poor physicochemical stability. HQ formulations are currently elaborated by compounding in local pharmacies. Variability in the characteristics of HQ topical formulations can lead to remarkable differences in terms of their stability, efficacy, and toxicity. Read More

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http://dx.doi.org/10.3390/pharmaceutics11040167DOI Listing

Effects of Extra Virgin Olive Oil and Apples Enriched-Dark Chocolate on Endothelial Progenitor Cells in Patients with Cardiovascular Risk Factors: A Randomized Cross-Over Trial.

Antioxidants (Basel) 2019 Apr 4;8(4). Epub 2019 Apr 4.

Cardiovascular Research Laboratory, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56100 Pisa, Italy.

Background: Endothelial dysfunction has been associated to cardiovascular outcomes in patients with cardiovascular risk factors. Circulating endothelial progenitor cells (EPCs) play an important physiological role for their reparative potential of vascular integrity, but are numerically reduced and functionally impaired in patients with cardiovascular risks. This study assesses the effects of Extra Virgin Olive Oil (EVOO) and apple-enriched dark chocolate intake on the blood levels of EPCs. Read More

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http://dx.doi.org/10.3390/antiox8040088DOI Listing

Plasma Malondialdehyde and Risk of New-Onset Diabetes after Transplantation in Renal Transplant Recipients: A Prospective Cohort Study.

J Clin Med 2019 Apr 4;8(4). Epub 2019 Apr 4.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

New-onset diabetes after transplantation (NODAT) is a frequent complication in renal transplant recipients (RTR). Although oxidative stress has been associated with diabetes mellitus, data regarding NODAT are limited. We aimed to prospectively investigate the long-term association between the oxidative stress biomarker malondialdehyde (measured by high-performance liquid chromatography) and NODAT in an extensively phenotyped cohort of non-diabetic RTR with a functioning graft ≥1 year. Read More

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http://dx.doi.org/10.3390/jcm8040453DOI Listing

Luteolin 7-Sulfate Attenuates Melanin Synthesis through Inhibition of CREB- and MITF-Mediated Tyrosinase Expression.

Antioxidants (Basel) 2019 Apr 4;8(4). Epub 2019 Apr 4.

Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea.

Antioxidants with antimelanogenic activity are potentially useful for the attenuation of skin hyperpigmentation disorders. In a previous study, luteolin 7-sulfate isolated from Makino, a marine plant, was shown to inhibit cellular melanin synthesis. The aim of the present study was to examine its action mechanism, focusing on the regulation of tyrosinase (TYR) expression in cells. Read More

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http://dx.doi.org/10.3390/antiox8040087DOI Listing

A Review of Defined Oxidative Balance Scores Relative to Their Components and Impact on Health Outcomes.

Nutrients 2019 Apr 3;11(4). Epub 2019 Apr 3.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

Oxidative Balance Scores (OBSs) are tools that have emerged to evaluate the global balance of individuals' oxidation-reduction status. The aim was to compare OBSs available in the literature regarding their characteristics and associations with chronic diseases in epidemiological studies. Studies that developed OBSs were searched in PubMed until August 2018. Read More

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http://dx.doi.org/10.3390/nu11040774DOI Listing

Antioxidant and Antimicrobial Activity of Rosemary, Pomegranate and Olive Extracts in Fish Patties.

Antioxidants (Basel) 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Food Technology, Nutrition and Food Science, Veterinary Faculty University of Murcia, Campus de Espinardo, 30100 Espinardo, Murcia, Spain.

Natural extracts (rich in bioactive compounds) that can be obtained from the leaves, peels and seeds, such as the studied extracts of Pomegranate (P), Rosemary (RA, Nutrox OS (NOS) and Nutrox OVS (NOVS)), and olive () extracts rich in hydroxytyrosol (HYT-F from olive fruit and HYT-L from olive leaf) can act as antioxidant and antimicrobial agents in food products to replace synthetic additives. The total phenolic compounds, antioxidant capacity (measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-Azinobis (3-ethylbenzothiazolin) -6-sulphonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP), and Oxygen Radical Absorbance Capacity (ORAC)) and their antimicrobial power (using the diffusion disk method with the and strains) were measured. The results showed that all the extracts were good antioxidant and antimicrobial compounds in vitro. Read More

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http://dx.doi.org/10.3390/antiox8040086DOI Listing

Luteolin Shifts Oxaliplatin-Induced Cell Cycle Arrest at G₀/G₁ to Apoptosis in HCT116 Human Colorectal Carcinoma Cells.

Nutrients 2019 Apr 2;11(4). Epub 2019 Apr 2.

School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea.

Certain antioxidative flavonoids are known to activate nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidants and detoxifying response and is reportedly highly activated in many types of cancers. Few studies on the potential undesired effects of flavonoid intake during chemotherapy have been conducted, yet Nrf2 activators could favor cancer cell survival by attenuating chemotherapeutic efficiency. This study aimed to examine if luteolin, an Nrf2 activator, hinders chemotherapeutic activity of oxaliplatin, a potent anticancer agent for colorectal cancer, in HCT116 cells. Read More

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https://www.mdpi.com/2072-6643/11/4/770
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http://dx.doi.org/10.3390/nu11040770DOI Listing
April 2019
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Nutrients for Prevention of Macular Degeneration and Eye-Related Diseases.

Antioxidants (Basel) 2019 Apr 2;8(4). Epub 2019 Apr 2.

Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, No. 1, Jalan Menara Gading, UCSI Heights, Kuala Lumpur 56000, Malaysia.

The risk of macular degeneration can be reduced through the consumption of antioxidant-rich foods, supplements, and nutraceutical formulas. This review focuses on the antioxidants, vitamins, and minerals that have been reported for reducing the risk of macular degeneration and other eye-related diseases. Antioxidants including anthocyanins, carotenoids, flavonoids, and vitamins have been shown to reduce the risk of eye-related diseases. Read More

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https://www.mdpi.com/2076-3921/8/4/85
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http://dx.doi.org/10.3390/antiox8040085DOI Listing
April 2019
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Dandelion is more tolerant to cadmium than to nickel excess.

Chemosphere 2019 Jun 27;224:884-891. Epub 2019 Feb 27.

Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria.

Comparative accumulation of cadmium (Cd) and nickel (Ni) and the consequences for the metabolism of common weed dandelion (triploid ones of Taraxacum sect. Taraxacum) were studied here for the first time. Cd accumulated more in both shoots and roots (489 and 2486 μg/g DW) than Ni (165 and 858 μg/g DW) after 14 days of exposure and only root Ni content did not increase between 7 and 14 days of exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193040
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http://dx.doi.org/10.1016/j.chemosphere.2019.02.181DOI Listing
June 2019
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Binary-ternary Cd(II)-(hydroxycarboxylic acid)-(aromatic chelator) systems exhibit in vitro cytotoxic selectivity in a tissue-specific manner.

J Inorg Biochem 2019 Feb 23;195:201-215. Epub 2019 Feb 23.

Laboratory of Inorganic Chemistry and Advanced Materials, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

Cadmium is a metallotoxin, amply encountered in the environment and derived through physical and anthropogenic activities. Its entry in various organisms leads through water and the food chain to humans, thereby inducing a plethora of pathophysiologies. Delineation of the interactive role of cadmium with physiological and physiologically relevant substrates, requires well-defined forms of cadmium arising from such interactions along with the ensuing chemical reactivity amounting to toxic manifestations and health aberrations. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.009DOI Listing
February 2019
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Ascorbic acid formulation for survivability and diazotrophic efficacy of Azotobacter chroococcum Avi2 (MCC 3432) under hydrogen peroxide stress and its role in plant-growth promotion in rice (Oryza sativa L.).

Plant Physiol Biochem 2019 Apr 6;139:419-427. Epub 2019 Apr 6.

ICAR- National Rice Research Institute, Cuttack, Odisha, 753006, India.

Oxidative stress generates reactive oxygen species which causes cell damage of living organisms and are normally detoxified by antioxidants. Indirect reports signify the damages caused by reactive oxygen species and neutralized by antioxidant, but the direct evidence to confirm this hypothesis is still unclear. To validate our hypothesis, an attempt was made in a diazotrophic bacterium (Azotobacter chroococcum Avi2) as a biological system, and hydrogen peroxide (HO) and ascorbic acid were used as oxidative stress and antioxidant supplement, respectively. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.04.003DOI Listing

Dynamic, shear and pasting behaviour of native and octenyl succinic anhydride (OSA) modified wheat starch and their utilization in preparation of edible films.

Int J Biol Macromol 2019 Apr 12. Epub 2019 Apr 12.

Department of Food Science and Technology, Guru Nanak Dev University, Amritsar, India.

Starch-based edible films could offer non-chemical means for preserving perishable commodities. The present research investigated the effectiveness of native and heat treated Octenyl succinic anhydride (OSA) modified wheat starch in edible film making. Pasting and rheological properties of the native and OSA modified starch as well as antioxidants and sensorial attributes of coated and non-coated grapes were evaluated. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.089DOI Listing

Structural characterization, antioxidant and antibacterial activities of two heteropolysaccharides purified from the bulbs of Lilium davidii var. unicolor Cotton.

Int J Biol Macromol 2019 Apr 12. Epub 2019 Apr 12.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China. Electronic address:

Two heteropolysaccharides, BHP-1 and BHP-2, were separated and purified from the edible bulbs of Lilium davidii var. unicolor Cotton by anion-exchange and gel-permeation chromatography. The primary structural characteristics of BHP-1 and BHP-2 were investigated by Congo red test, X-ray diffractometry (XRD) analysis, IR, GC and NMR. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.082DOI Listing
April 2019
2.858 Impact Factor

Safety assessment of antioxidants and color fixatives for the Korean population using dietary intake monitoring.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Food Additives and Packaging Division , National Institute of Food and Drug Safety Evaluation , Cheongju , Republic of Korea.

Food additives such as antioxidants and color fixatives are substances used in food intentionally for technical effect, such as decolorizing or intensifying the color of food. Based on the necessity of re-evaluating food additives for safety and to improve consumer perception, we conducted safety assessments for food additives according to the Risk Assessment Guidelines of the Korean Ministry of Food and Drug Safety. These safety assessments evaluated new risk information based on toxicology data and estimates of dietary intake exposures to food additives in comparison with the acceptable daily intake (ADI). Read More

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http://dx.doi.org/10.1080/19440049.2019.1595172DOI Listing

Reducing oxidative toxicity of L-dopa in combination with two different antioxidants: an essential oil isolated from Rosa Damascena Mill., and vitamin C.

Toxicol Rep 2019 22;6:267-271. Epub 2019 Mar 22.

Department of chemistry and biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.

Parkinson disease (PD) is a multifactorial disease that takes a leading place among contemporary frequent diseases of the central nervous system (CNS) with not well-established mechanism. One of the most popular and effective therapy for patients with PD is Levodopa (L-dopa), but clinical effect of the drug diminished by motor complications resulting from prolonged treatment. Due to the L-dopa neurotoxic effect in the disease treatment, the L-dopa administration is delayed as long as possible in order to avoid side effects. Read More

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http://dx.doi.org/10.1016/j.toxrep.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444129PMC

NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation.

FEBS Open Bio 2019 Apr 23;9(4):582-593. Epub 2019 Feb 23.

Department of Biological Sciences St John's University Queens NY USA.

Ferroptosis is a form of regulated cell death that is driven by lethal accumulation of lipid peroxides upon inhibition of glutathione peroxidase 4 (GPx4). Deletion of the gene in mice revealed that neurons are sensitive to ferroptosis . However, few studies have been conducted on ferroptosis regulation in neurons. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/2211-5463.12
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http://dx.doi.org/10.1002/2211-5463.12577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443867PMC
April 2019
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Antioxidant effects of kimchi supplemented with black raspberry during fermentation protect against liver cirrhosis-induced oxidative stress in rats.

Nutr Res Pract 2019 Apr 8;13(2):87-94. Epub 2019 Mar 8.

World Institute of Kimchi, 86 Kimchiro, Namgu, Gwangju 61755, Korea.

Background/objectives: Oxidative stress is a major effector of various diseases; accordingly, antioxidants are frequently ingested in order to prevent or alleviate disease symptoms. Kimchi contains various natural antioxidants, and it is known that the functional activity varies depending on the ingredients and fermentation state. Black raspberries (BR) contain various bioactive compounds with antioxidant effects. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4162/nrp.2019.13
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http://dx.doi.org/10.4162/nrp.2019.13.2.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449543PMC
April 2019
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Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis.

Oxid Med Cell Longev 2019 10;2019:8403578. Epub 2019 Mar 10.

Conservative Dentistry Department, Medical University in Bialystok, Poland.

Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of AP rats. Male Wistar rats were divided equally into 2 groups: control ( = 9) and AP ( = 9). Read More

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http://dx.doi.org/10.1155/2019/8403578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431492PMC

Hydrogen and Oxygen Mixture to Improve Cardiac Dysfunction and Myocardial Pathological Changes Induced by Intermittent Hypoxia in Rats.

Oxid Med Cell Longev 2019 7;2019:7415212. Epub 2019 Mar 7.

Department of Physiology, Institute of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.

Obstructive sleep apnea (OSA) can cause intermittent changes in blood oxygen saturation, resulting in the generation of many reactive oxygen species (ROS). To discover new antioxidants and clarify the endoplasmic reticulum (ER) stress involved in cardiac injury in OSA, we established a chronic intermittent hypoxia (CIH) rat model with a fraction of inspired O (FiO) ranging from 21% to 9%, 20 times/h for 8 h/day, and the rats were treated with H-O mixture (67% hydrogen and 33% oxygen) for 2 h/day for 35 days. Our results showed that H-O mixture remarkably improved cardiac dysfunction and myocardial fibrosis. Read More

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http://dx.doi.org/10.1155/2019/7415212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431505PMC

Proteomics Reveal Enhanced Oxidative Stress Responses and Metabolic Adaptation in Biofilm Cells on Pyrite.

Front Microbiol 2019 29;10:592. Epub 2019 Mar 29.

Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

Reactive oxygen species (ROS) cause oxidative stress and growth inhibition by inactivation of essential enzymes, DNA and lipid damage in microbial cells. Acid mine drainage (AMD) ecosystems are characterized by low pH values, enhanced levels of metal ions and low species abundance. Furthermore, metal sulfides, such as pyrite and chalcopyrite, generate extracellular ROS upon exposure to acidic water. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450195PMC

The role of silver ions in the regulation of the senescence process in Triticum aestivum.

Turk J Biol 2018 10;42:517-526. Epub 2018 Dec 10.

Department of Biology Education, Faculty of Education, Mersin University , Mersin , Turkey.

The control of senescence has economic importance due to its effects on parameters such as herbal product quality and shelf life. This study is on the control of induced senescence in Triticum aestivum L. 'Gün-91' plants with silver nitrate (AgNO3) treatments. Read More

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http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=b
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http://dx.doi.org/10.3906/biy-1802-95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451841PMC
December 2018
1 Read

Effect of selenium and pentoxifylline on expression of CATSPER1 and 2 genes and FSH/LH levels in treated mice by dexamethasone.

Andrologia 2019 Apr 14:e13279. Epub 2019 Apr 14.

Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Dexamethasone has deleterious effects on male fertility and sperm parameters. In this study, the effect of dexamethasone on expression of CATSPER1 and 2 genes was investigated. These two genes play an important role in sperm motility. Read More

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http://dx.doi.org/10.1111/and.13279DOI Listing

Nutrition, osteoarthritis and cartilage metabolism.

Aging Clin Exp Res 2019 Apr 13. Epub 2019 Apr 13.

Centro de Diagnóstico de Osteoporosis y Enfermedades Reumáticas (CEDOR), Lima, Peru.

Background: Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA and there is no effective treatment to stop its progression. Current pharmacologic treatments such as analgesics and non-steroidal anti-inflammatory drugs may improve the pain and offer some relief but they do not affect the progression of the disease. Read More

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http://link.springer.com/10.1007/s40520-019-01191-w
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http://dx.doi.org/10.1007/s40520-019-01191-wDOI Listing
April 2019
6 Reads

Myocardial protection by propolis during prolonged hypothermic preservation.

Cryobiology 2019 Apr 11. Epub 2019 Apr 11.

U955-IMRB, équipe 03, Inserm, UPEC, Ecole Nationale Vétérinaire d'Alfort, Créteil, France.

Oxidative stress is involved in the pathogenesis of ischemia-reperfusion during myocardial transplantation. Therefore, graft preservation solutions may be improved by supplementation with antioxidants to minimize graft dysfunction caused by cold ischemic injury. Propolis is a polyphenol-rich substance which has an important antioxidant activity. Read More

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http://dx.doi.org/10.1016/j.cryobiol.2019.04.003DOI Listing
April 2019
1 Read

Effect of dietary grape marc on fresh and refrigerated boar semen.

Anim Reprod Sci 2019 Mar 27. Epub 2019 Mar 27.

University of Teramo, Faculty of Biosciences and Technologies for Agriculture Food and Environment, Via R. Balzarini 1, 64100, Teramo, Italy.

In several studies there has been evaluation of the dietary addition of antioxidants to improve the quality of fresh and stored semen in domestic animals. Grape marc (GM), as the residue of vinification, contains large amounts of polyphenols with antioxidant, anti-inflammatory, antimicrobial, and antiaging effects. In this study, two regimens of dietary GM supplementation (2% and 4%) were tested regarding effects on the characteristics and lipid peroxidation of fresh and stored semen. Read More

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http://dx.doi.org/10.1016/j.anireprosci.2019.03.016DOI Listing

Biodegradable antioxidant chitosan films useful as an anti-aging skin mask.

Int J Biol Macromol 2019 Apr 10. Epub 2019 Apr 10.

UNIFESP - Federal São Paulo University, Institute of Environmental, Chemical and Pharmaceutical Science, SP, Brazil.

Cosmetics, personal care and biomedical products obtained by bio-based polymers and natural bioactive compounds are a new growing market. The ecological awareness is changing consumers' demands, causing consumers to look for more sustainable options, with a reduced environmental impact. The innovation of this work was to develop a natural polymer matrix (chitosan) entrapping antioxidant actives compounds such as annatto (Bixa Orellana L. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183656
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.052DOI Listing
April 2019
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Formation of an antioxidant profile in the sea trout (Salmo trutta m. trutta L.) from the Slupia River.

Authors:
Natalia Kurhaluk

Zoology (Jena) 2019 Apr 18;133:54-65. Epub 2019 Feb 18.

Department of Physiology, Institute of Biology and Environmental Protection, Pomeranian University of Slupsk, Arciszewskiego 22b Str., 76-200, Slupsk, Poland. Electronic address:

Using a stage- and sex-based multivariate significance tests on the sea trout Salmo trutta m. trutta L. model, we show dependencies in the balance between lipid peroxidation processes, levels of carbonyl derivatives, and activity of antioxidant enzymes (superoxide dismutase SOD, catalase CAT, glutathione reductase GR, and peroxidase GPx) in the processes of antioxidant profile formation during the fish growing process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09442006183014
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http://dx.doi.org/10.1016/j.zool.2019.02.002DOI Listing
April 2019
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Effect of Impregnation of Biodegradable Polyesters with Polyphenols from and Walnut Green Husk.

Polymers (Basel) 2019 Apr 11;11(4). Epub 2019 Apr 11.

Lodz University of Technology, Institute of Polymer and Dye Technology, ul. Stefanowskiego 12/16, 90-924 Lodz, Poland.

The publication describes a process combining the extraction of plant material and impregnation of biodegradable polymers (polylactide (PLA) and polyhydroxyalkanoate (PHA)). As raw plant materials for making extracts, and green walnut husk were selected due to their high content of active phytochemicals, including antioxidants. The extracts used to impregnate polymers contained valuable polyphenolic compounds, as confirmed by FTIR and UV-Vis spectroscopy. Read More

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https://www.mdpi.com/2073-4360/11/4/669
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http://dx.doi.org/10.3390/polym11040669DOI Listing
April 2019
3 Reads

Total Phenolic Content, Flavonoid Content and Antioxidant Potential of Wild Vegetables from Western Nepal.

Plants (Basel) 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Natural Products Research, Dr. Koirala Research Institute for Biotechnology and Biodiversity, Kathmandu 44600, Nepal.

Eight selected wild vegetables from Nepal (, , , , , , and ) were investigated for their antioxidative potential using 2,2-dyphenyl-1-picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H₂O₂), ferric reducing antioxidant power (FRAP), and ferric thiocyanate (FTC) methods. Among the selected plant extracts displayed the highest DPPH radical scavenging activity with an IC value 9.898 μg/mL, whereas had the maximum H₂O₂ scavenging activity with an IC value 16. Read More

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http://dx.doi.org/10.3390/plants8040096DOI Listing

Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma.

Antioxidants (Basel) 2019 Apr 11;8(4). Epub 2019 Apr 11.

Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia.

We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Read More

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http://dx.doi.org/10.3390/antiox8040097DOI Listing

Water- and Fat-Soluble Antioxidants in Human Seminal Plasma and Serum of Fertile Males.

Antioxidants (Basel) 2019 Apr 11;8(4). Epub 2019 Apr 11.

Alma Res Fertility Center, Centro di Fecondazione Assistita Alma Res, Via Parenzo 12, 00199 Rome, Italy.

Reactive oxygen species (ROS) are physiologically involved in functions like sperm maturation, capacitation and acrosome reaction, but their excess is involved in male infertility. Antioxidants in seminal plasma (SP) are an important factor balancing physiologic and harmful ROS activities. In this study, we determined and compared the full profiles of the water- and fat-soluble antioxidants in SP and serum of 15 healthy fertile subjects (ranging between the ages of 35 and 42 years). Read More

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https://www.mdpi.com/2076-3921/8/4/96
Publisher Site
http://dx.doi.org/10.3390/antiox8040096DOI Listing
April 2019
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Copper accumulation, subcellular partitioning, and physiological and molecular responses in relation to different copper tolerance in apple rootstocks.

Tree Physiol 2019 Apr 12. Epub 2019 Apr 12.

Institute of Pomology, Shandong Academy of Agricultural Sciences, Tai'an, People's Republic of China.

To unravel physiological and molecular regulation mechanisms underlying the variation in Cu accumulation, translocation, and tolerance among five apple rootstocks, seedlings were exposed to either basal or excess Cu. Excess Cu suppressed plant biomass and root architecture, which was less pronounced in Malus prunifolia, indicating its relatively higher Cu tolerance. Among the five apple rootstocks, M. Read More

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http://dx.doi.org/10.1093/treephys/tpz042DOI Listing
April 2019
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Furan formation from ingredients interactions and furan mitigation by sugar alcohols and AOB in milk beverage model systems.

J Sci Food Agric 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, People's Republic of China.

Background: Furan is a potential carcinogen that can be formed in various heat-treated foods including milk beverage. Studies on the formation and mitigation of furan in milk beverage are rare. In the present study, the effect of ingredients on furan formation and the reduction of furan in milk beverage model system by sugar alcohols and antioxidants of bamboo leaves (AOB) were investigated. Read More

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http://dx.doi.org/10.1002/jsfa.9739DOI Listing
April 2019
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Olive leaves extract attenuates type II diabetes mellitus-induced testicular damage in rats: Molecular and biochemical study.

Saudi Pharm J 2019 Mar 29;27(3):326-340. Epub 2018 Nov 29.

Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942 Al Kharj, Saudi Arabia.

Diabetes mellitus (DM) has emerged as a public healthcare problem. Sustained hyperglycemia has been linked with many complications including impaired male fertility Olive tree ( L.) leaves have been extensively used in traditional remedies worldwide to control blood glucose level in DM. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438850PMC

Hypolipidemic Effect of Chrysophyllum albidum Peel Extract and Its Underlying Antioxidant Mechanisms in Normal and Triton-X-100-Induced Hyperlipidemic Rats.

J Diet Suppl 2019 Apr 12:1-19. Epub 2019 Apr 12.

a Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences , University of Ibadan , Ibadan , Nigeria.

Chrysophyllum albidum peel ethanol extract (CAPEE) was investigated for its antioxidant and hypolipidemic effects in rats. Dried peel was extracted in 70% ethanol and tested for phenolic content and in vitro antioxidant properties. Acute toxicity effect of CAPEE was tested at dose level of 2,000 mg/kg. Read More

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http://dx.doi.org/10.1080/19390211.2019.1591563DOI Listing

Polyphenols in Almond Skins after Blanching Modulate Plasma Biomarkers of Oxidative Stress in Healthy Humans.

Antioxidants (Basel) 2019 Apr 10;8(4). Epub 2019 Apr 10.

Antioxidants Research Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Almond skins are a waste byproduct of blanched almond production. Polyphenols extracted from almond skins possess antioxidant activities in vitro and in vivo. Thus, we examined the pharmacokinetic profile of almond skin polyphenols (ASP) and their effect on measures of oxidative stress. Read More

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http://dx.doi.org/10.3390/antiox8040095DOI Listing

Antinociceptive effects and markers of oxidative stress of extract enriched with active indole alkaloids from leaves of Tabernaemontana catharinensis.

J Ethnopharmacol 2019 Apr 9:111863. Epub 2019 Apr 9.

Laboratory of Biotechnology of Natural and Synthetic Products, University of Caxias do Sul, Brazil. Electronic address:

Ethnopharmacological Relevance: Ethnopharmacological knowledge is important for the identification of active compounds from natural products. Pain may have different aetiologies with complex mechanisms. Tabernaemontana catharinensis is well known for indole alkaloids, being used empirically in folk medicine, with antimicrobial and anti-inflammatory as well as antiofidic actions among others. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111863DOI Listing
April 2019
1 Read