512,546 results match your criteria Antioxidants & redox signaling[Journal]


Role of amino acids in regulation of ROS balance in cancer.

Arch Biochem Biophys 2020 Jun 1:108438. Epub 2020 Jun 1.

Centre de Recherche en Cancérologie de Marseille (CRCM), UMR 1068, Institut National de la Santé et de la Recherche Médicale, F-13009, Marseille, France; Institut Paoli-Calmettes (IPC), F-13009, Marseille, France; Unité Mixte de Recherche (UMR 7258), Centre National de la Recherche Scientifique (CNRS), F-13009, Marseille, France; Université Aix-Marseille U105, F-13284, Marseille, France. Electronic address:

Cancer cells display increased oxidative stress from reactive oxygen species (ROS) and constantly have to counteract them below a tolerable threshold to avoid any toxicity due to overload of ROS. The involvement of ROS in cancer progression from precursor lesions to aggressive tumor and metastasis formation is still debated, but it is recognized that cancer cells succeed to use ROS for their own benefit in circumstances that are tumor cell-type specific. In this review we focus on amino acids' metabolic pathways that tumor cells activate as antioxidants including cysteine, methionine metabolisms and their connection with the folate, transulfuration pathways and ferroptosis. Read More

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http://dx.doi.org/10.1016/j.abb.2020.108438DOI Listing

Oxidative and nitrosative stress involvement in the pathogenesis of obstructive lung diseases of increasing severity.

Curr Med Chem 2020 Jun 4. Epub 2020 Jun 4.

Dipartimento di Scienze Cliniche e Biologiche, AOU, San Luigi, Orbassano, Università di Torino, Torino. Italy.

The imbalance between increased oxidative agents and antioxidant defence mechanisms is central in the pathogenesis of obstructive lung diseases such as asthma and COPD. In these patients, there are increased levels of reactive oxygen species. Superoxide anions (O2 - ), hydrogen peroxide (H2O2) and hydroxyl radicals (. Read More

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http://dx.doi.org/10.2174/0929867327666200604165451DOI Listing

Comparative stability of arbutin in Arctostaphylos uva-ursi by a new comprehensive stability-indicating HPLC method.

Phytochem Anal 2020 Jun 4. Epub 2020 Jun 4.

Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Introduction: Arbutin is a phenol glucoside found in high concentrations in bearberry leaves and associated with the antimicrobial activity of the plant. Hydroquinone can also be found in leaves or be formed by degradation of arbutin. Lengthy exposure to free hydroquinone is associated with induction of toxicity in different organs. Read More

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http://dx.doi.org/10.1002/pca.2953DOI Listing

Origanum compactum Benth., from traditional use to biotechnological applications.

J Food Biochem 2020 Jun 4:e13251. Epub 2020 Jun 4.

Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Origanum compactum Benth., is a Moroccan medicinal plant known by its local name as Zaatar. In Morocco, it has various traditional applications such as the use to treat diabetes, metabolic disorders, digestive, and respiratory problems. Read More

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http://dx.doi.org/10.1111/jfbc.13251DOI Listing

The prophylactic effect of date palm ( L.) fruit extract on testicular toxicity induced by formaldehyde: An experimental study.

Int J Reprod Biomed (Yazd) 2020 Apr 30;18(4):275-286. Epub 2020 Apr 30.

Department of Anatomical Sciences, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background: Formaldehyde (FA) is one of the most widely used materials in industries and in sciences. Prolonged contact with FA might have harmful effects on fertility due to the increase in the reactive oxygen species level. On the other hand, date palm () fruit extract (DPFE) contains a high concentration of natural antioxidants that could scavenge free radicals. Read More

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http://dx.doi.org/10.18502/ijrm.v13i4.6890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218671PMC

Linagliptin, when compared to placebo, improves CD34+ve endothelial progenitor cells in type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin: a randomized controlled trial.

Cardiovasc Diabetol 2020 Jun 3;19(1):72. Epub 2020 Jun 3.

The GW Medical Faculty Associates, 2300 M Street NW, Washington, DC, 20037, USA.

Background: Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. EPCs have been shown to be a robust cardiovascular disease (CVD) risk indicator. Cellular mechanisms of DPP4 inhibitors such as linagliptin (LG) on CVD risk, in patients with T2DM with established CKD has not been established. Read More

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http://dx.doi.org/10.1186/s12933-020-01046-zDOI Listing

AOP1, a New Live Cell Assay for the Direct and Quantitative Measure of Intracellular Antioxidant Effects.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

AOP/MH2F-LAAS/CNRS, 7 avenue du Colonel Roche, BP 54200, 31031 Toulouse, France.

Taking advantage of Light Up Cell System (LUCS) technology, which allows for fine monitoring of reactive oxygen species (ROS) production inside live cells, a new assay called Anti Oxidant Power 1 (AOP1) was developed to specifically measure ROS and/or free-radical scavenging effects inside living cells. This method is quantitative and ECs obtained from AOP1 dose-response experiments were determined in order to classify the intracellular antioxidant efficacy of 15 well known antioxidant compounds with different hydrophilic properties. Six of them (epigallocatechin gallate, quercetin, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), ethoxyquin, resveratrol) gave ECs in the range of 7-64 μM, four (Trolox, catechin, epicatechin, EUK134) in the range of 0. Read More

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http://dx.doi.org/10.3390/antiox9060471DOI Listing

Screening of Natural Stilbene Oligomers from for Anticancer Activity on Human Hepatocellular Carcinoma Cells.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Free Radicals and Oxidative Stress (FROS) research group of the Department of Physiology, Medicine and Nursing School, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.

The characterization of bioactive resveratrol oligomers extracted from canes has been recently reported. Here, we screened six of these compounds (ampelopsin A, ε-viniferin, hopeaphenol, isohopeaphenol, R2-viniferin, and R-viniferin) for their cytotoxic activity to human hepatocellular carcinoma (HCC) cell lines p53 wild-type HepG2 and p53-null Hep3B. The cytotoxic efficacy depended on the cell line. Read More

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http://dx.doi.org/10.3390/antiox9060469DOI Listing

Anti-Migratory Effects of 4'-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Medicine and Science of Aging, University "G. D'Annunzio", 66100 Chieti-Pescara, Italy.

Matrix metalloproteinases (MMPs) play a crucial role in tumor angiogenesis, and metastasis. 4'-geranyloxyferulic acid (GOFA) has anti-tumor and anti-inflammatory proprieties. Herein, we aimed to determine whether this compound affects cell survival, invasion, and migration through reactive oxygen species (ROS)-mediated MMPs activation of extracellular signal-regulated kinases (ERKs) and p38 signaling in lymphocytic histiocytoma (U937) and colorectal cancer (HCT116) cells. Read More

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http://dx.doi.org/10.3390/antiox9060470DOI Listing

Emission-related Heavy Metal Associated with Oxidative Stress in Children: Effect of Antioxidant Intake.

Int J Environ Res Public Health 2020 Jun 1;17(11). Epub 2020 Jun 1.

Institute of Environmental and Occupational Health Science, College of Public Health, National Taiwan University, No. 17, Xu-Zhou Road, Taipei 10055, Taiwan.

Heavy metals, the common pollutants emitted from industrial activities, are believed to cause harmful effects, partially through the mechanism of elevated oxidative stress, and antioxidant intake has been hypothesized to provide a potential protective effect against oxidative stress. This study aims to investigate the heavy metal exposure and the associated oxidative damage of young children living near a petrochemical complex and to assess the protective effect of antioxidant intake. There were 168 children recruited from the kindergartens near a huge petrochemical complex, with 87 as the high exposure group and 81 as the low exposure group. Read More

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http://dx.doi.org/10.3390/ijerph17113920DOI Listing

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (HO)MnTnHex-2-PyP.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, (HO)MnTnHex-2-PyP (MnHex) carrying long hexyl chains, is a lipophilic mimic of superoxide dismutase (SOD) and a redox-active drug candidate. MnHex crosses the blood-brain barrier, and improved neurologic outcome and decreased infarct size and inflammation in a rat middle cerebral artery occlusion (MCAO) ischemic stroke model. Yet, the dose and the therapeutic efficacy of Mn porphyrin were limited by an adverse effect of arterial hypotension. Read More

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http://dx.doi.org/10.3390/antiox9060467DOI Listing

When Oxidative Stress Meets Epigenetics: Implications in Cancer Development.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Epigenetics laboratory, INGEMM, Hospital La PAZ, 28046 Madrid, Spain.

Cancer is one of the leading causes of death worldwide and it can affect any part of the organism. It arises as a consequence of the genetic and epigenetic changes that lead to the uncontrolled growth of the cells. The epigenetic machinery can regulate gene expression without altering the DNA sequence, and it comprises methylation of the DNA, histones modifications, and non-coding RNAs. Read More

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http://dx.doi.org/10.3390/antiox9060468DOI Listing

An Environmentally Friendly Practice Used in Olive Cultivation Capable of Increasing Commercial Interest in Waste Products from Oil Processing.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80141 Naples, Italy.

In the Rural Development Plan (2014-2020), the European Commission encouraged the conversion and supported the maintenance of organic farming. Organic olive oil (bioEVOO) production involves the use of environmentally sustainable fertilizers and the recycling of olive pomace (Pom) and olive vegetation waters (VW) to reduce the environmental impact of these wastes. An ecofriendly way to recycle olive wastes is to reuse them to extract bioactive compounds. Read More

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http://dx.doi.org/10.3390/antiox9060466DOI Listing

Chemical Characterization and Bioactive Properties of Different Extracts from , an Unexplored Plant Food.

Foods 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Pharmaceutical Sciences, Food Science and Nutrition Section, University of Perugia, Via S. Costanzo 1, 06126 Perugia, Italy.

(L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. Read More

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http://dx.doi.org/10.3390/foods9060705DOI Listing

Species-Specific, pH-Independent, Standard Redox Potential of Selenocysteine and Selenocysteamine.

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Pharmaceutical Chemistry, Semmelweis University, H-1092 Budapest, Hungary.

Microscopic redox equilibrium constants and standard redox potential values were determined to quantify selenolate-diselenide equilibria of biological significance. The highly composite, codependent acid-base and redox equilibria of selenolates could so far be converted into pH-dependent, apparent parameters (equilibrium constants, redox potentials) only. In this work, the selenolate-diselenide redox equilibria of selenocysteamine and selenocysteine against dithiothreitol were analyzed by quantitative nuclear magnetic resonance (NMR) methods to characterize the interfering acid-base and redox equilibria. Read More

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http://dx.doi.org/10.3390/antiox9060465DOI Listing

Reply to Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis. 2020, (3), 195".

Antioxidants (Basel) 2020 Jun 1;9(6). Epub 2020 Jun 1.

Institute of Medical Sciences, University of Aberdeen, Aberdeen AB41 8TJ, UK.

We thank Drs Hegarty and Byrne for their interest in our paper and appreciate the opportunity to respond to their insightful comments [... Read More

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http://dx.doi.org/10.3390/antiox9060464DOI Listing

Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.

Clin Mol Hepatol 2020 Jun 4. Epub 2020 Jun 4.

Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan.

Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish stellate cells from hepatic fibroblast-derived myofibroblasts. Loss of Cygb accelerates liver fibrosis and cancer development in mouse models of chronic liver injury including diethylnitrosamine-induced hepatocellular carcinoma, bile duct ligation-induced cholestasis, thioacetamide-induced hepatic fibrosis, and choline-deficient L-amino acid-defined diet-induced non-alcoholic steatohepatitis. Read More

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http://dx.doi.org/10.3350/cmh.2020.0037DOI Listing

Quality characteristics of white wine: The short- and long-term impact of high power ultrasound processing.

Ultrason Sonochem 2020 May 29;68:105194. Epub 2020 May 29.

University of Zagreb, Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia.

This research aimed to analyze the effects of ultrasound on the quality characteristics of white wine when processed by two different systems, i.e., ultrasonic bath and ultrasonic probe. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2020.105194DOI Listing

[Healthy Aging: Antioxidants, Uncouplers and/or Telomerase?]

Authors:
Y E Yegorov

Mol Biol (Mosk) 2020 May-Jun;54(3):355-361

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.

The free radical theory of aging was proposed in 1956. Although it does not fully describe the mechanisms of aging, it is generally accepted that reactive oxygen species (ROS) are one of the pathogenetic factors in aging and, in particular, in the development of pathologies associated with aging. The main source of ROS in the cell is mitochondria. Read More

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http://dx.doi.org/10.31857/S0026898420030052DOI Listing
November 2019

Brazilian red propolis extract enhances expression of antioxidant enzyme genes and .

Biosci Biotechnol Biochem 2020 Jun 3:1-11. Epub 2020 Jun 3.

Nagaragawa Research Center, API Co., Ltd , Gifu, Japan.

Brazilian red propolis reportedly has reactive oxygen species (ROS) scavenging effects , but the cellular mechanisms remain unclear. In the present study, the effects of an ethanol extract of Brazilian red propolis (EERP) on the Nrf2-ARE intracellular antioxidant pathway were examined and . EERP and its constituents transactivated the reporter gene through the ARE sequence and enhanced the expression of Nrf2-regulated genes in HEK293 cells. Read More

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http://dx.doi.org/10.1080/09168451.2020.1773756DOI Listing

Improved functional and nutritional properties of tomato fruit during cold storage.

Saudi J Biol Sci 2020 Jun 9;27(6):1467-1474. Epub 2020 Apr 9.

Plant Production Department, College of Food and Agriculture Sciences, King Saud University, PO Box 2460, Riyadh 11451, Saudi Arabia.

The use of synthetic antioxidants has been associated with serious concerns for human and environmental health. During ripening stages, tomato fruit is exposed to different abiotic stresses which not only influence its nutritional, mechanical, and functional properties at harvest, but also affect the quality and shelf life of the fruit during storage. This study investigated the pattern of changes in dietary antioxidants during various ripening stages of tomato fruit (cv. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254041PMC

Malaysian macroalga Hauck attenuates high dose corticosterone-mediated oxidative damage in PC12 cells mimicking the effects of depression.

Saudi J Biol Sci 2020 Jun 30;27(6):1435-1445. Epub 2020 Apr 30.

Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Oxidative damage has been associated with the pathophysiology of depression. Macroalgae are equipped with antioxidant defense system to counteract the effects of free radicals We explored the use of Malaysian to attenuate high dose corticosterone-mediated oxidative damage in a cellular model mimicking depression. Fresh specimen of was freeze-dried and extracted sequentially with hexanes, ethyl acetate and ethanol. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254034PMC

The role of honeybee pollen as a natural source of antioxidants in the in vitro maturation medium of sheep oocytes and its effect on gene expression.

Environ Sci Pollut Res Int 2020 Jun 1. Epub 2020 Jun 1.

Faculty of Science, Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 114511, Kingdom of Saudi Arabia.

This study aimed to investigate the effect of honeybee pollen as an antioxidant source in a maturation medium of sheep oocytes on the in vitro maturation rate, glutathione concentration, and gene expression. To our knowledge, this study might be the first of its kind in this field. Sheep oocytes were cultured in vitro with honeybee pollen at four different concentrations (0. Read More

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http://dx.doi.org/10.1007/s11356-020-09386-9DOI Listing

Simple, sensitive and specific quantification of diamine oxidase activity in complex matrices using newly discovered fluorophores derived from natural substrates.

Inflamm Res 2020 Jun 1. Epub 2020 Jun 1.

Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objective: To measure diamine oxidase (DAO) activity with high sensitivity in complex matrices like plasma or tissue extracts radioactive putrescine or horseradish peroxidase (HRP)/hydrogen peroxide (HO) coupling must be used. The use of radioactive material should be avoided and HRP/HO coupling is compromised by antioxidants.

Methods And Results: Condensation of ortho-aminobenzaldehyde (oABA) with delta-1-pyrroline and delta-1-piperideine, the autocyclization products of the DAO-oxidized natural substrates putrescine and cadaverine, generates new quinazoline fluorophores with absorption and excitation maxima of 430 and 460 nm, respectively, and peak emission at 620 nm. Read More

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http://dx.doi.org/10.1007/s00011-020-01359-5DOI Listing

Use of biogenic silver nanoparticles in enhancing shelf life of Morus alba L. at post harvest stage.

Sci Rep 2020 Jun 2;10(1):8923. Epub 2020 Jun 2.

Assistant Professor, Department of Botany, University of North Bengal, Raja Rammohanpur, Siliguri, West Bengal, 734013, India.

Morus alba is one of the most important cultivated crop in Indian sub-continent contributing towards production of silk fibre that carries economic importance worldwide. Post harvest preservation of M. alba leaves is a challenging factor as decrease in concentration of essential metabolites that needed for silk gland development takes place. Read More

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http://dx.doi.org/10.1038/s41598-020-65953-7DOI Listing

Functional and Structural Leaf Plasticity Determine Photosynthetic Performances during Drought Stress and Recovery in Two Platanus orientalis Populations from Contrasting Habitats.

Int J Mol Sci 2020 May 30;21(11). Epub 2020 May 30.

Department of Biology, Agriculture and Food Sciences, The National Research Council of Italy (CNR), 00185 Rome, Italy.

In the context of climatic change, more severe and long-lasting droughts will modify the fitness of plants, with potentially worse consequences on the relict trees. We have investigated the leaf phenotypic (anatomical, physiological and biochemical) plasticity in well-watered, drought-stressed and re-watered plants of two populations of , an endangered species in the west of the Mediterranean area. The two populations originated in contrasting climate (drier and warmer, Italy (IT) population; more humid and colder, Bulgaria (BG) population). Read More

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http://dx.doi.org/10.3390/ijms21113912DOI Listing

-Alkylaminoferrocene-Based Prodrugs Targeting Mitochondria of Cancer Cells.

Molecules 2020 May 29;25(11). Epub 2020 May 29.

Organic Chemistry Chair II, Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, 91058 Erlangen, Germany.

Intracellular concentration of reactive oxygen species (e.g., HO) in cancer cells is elevated over 10-fold as compared to normal cells. Read More

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http://dx.doi.org/10.3390/molecules25112545DOI Listing

Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis 2020, (3), 195".

Antioxidants (Basel) 2020 May 29;9(6). Epub 2020 May 29.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

Minter, B.E. et al. Read More

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http://dx.doi.org/10.3390/antiox9060462DOI Listing

Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics.

Molecules 2020 May 29;25(11). Epub 2020 May 29.

Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

The cosmetic industry is among the fastest growing industries in the last decade. As the beauty concepts have been revolutionized, many terms have been coined to accompany the innovation of this industry, since the beauty products are not just confined to those that are applied to protect and enhance the appearance of the human body. Consequently, the terms such as cosmeceuticals and nutricosmetics have emerged to give a notion of the health benefits of the products that create the beauty from inside to outside. Read More

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http://dx.doi.org/10.3390/molecules25112536DOI Listing

Restoration of Physiological Levels of Uric Acid and Ascorbic Acid Reroutes the Metabolism of Stored Red Blood Cells.

Metabolites 2020 May 29;10(6). Epub 2020 May 29.

Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interrégionale CRS, CH-1066 Epalinges, Switzerland.

After blood donation, the red blood cells (RBCs) for transfusion are generally isolated by centrifugation and then filtrated and supplemented with additive solution. The consecutive changes of the extracellular environment participate to the occurrence of storage lesions. In this study, the hypothesis is that restoring physiological levels of uric and ascorbic acids (major plasmatic antioxidants) might correct metabolism defects and protect RBCs from the very beginning of the storage period, to maintain their quality. Read More

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http://dx.doi.org/10.3390/metabo10060226DOI Listing

Review of Structural Features and Binding Capacity of Polyphenols to Gluten Proteins and Peptides In Vitro: Relevance to Celiac Disease.

Antioxidants (Basel) 2020 May 29;9(6). Epub 2020 May 29.

Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.

Polyphenols have been extensively studied due to their beneficial effects on human health, particularly for the prevention and treatment of diseases related to oxidative stress. Nevertheless, they are also known to have an anti-nutritional effect in relation to protein metabolism. This effect is a consequence of its binding to digestive enzymes and/or protein substrates. Read More

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http://dx.doi.org/10.3390/antiox9060463DOI Listing

N-Fertilizer (Urea) Enhances the Phytoextraction of Cadmium through L.

Int J Environ Res Public Health 2020 May 29;17(11). Epub 2020 May 29.

Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

Heavy metal contamination is currently a major environmental concern, as most agricultural land is being polluted from municipal discharge. Among various other pollutants, cadmium (Cd), one of the most harmful heavy metals, enters into the food chain through the irrigation of crops with an industrial effluent. In the present study, a pot experiment was designed to assess the effect of different nitrogen (N)-fertilizer forms in the phytoremediation of Cd through L. Read More

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http://dx.doi.org/10.3390/ijerph17113850DOI Listing

Cloning, functional characterisation and transgenic manipulation of vitamin E biosynthesis genes of wheat.

Funct Plant Biol 2013 Nov;40(11):1129-1136

Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi-110021, India.

Tocochromanols are an important group of plastidic lipophilic antioxidants that form an essential part of human diet and play important functions in photosynthetic organisms by protecting them from photo-oxidation, lipid peroxidation and membrane damage. Molecular genetics and genomics-based approaches have revealed the genes required for synthesis of these compounds in model organisms like rice, Arabidopsis and Synechocystis. To create a positive impact on human nutrition and health, the levels of total and specific tocochromanols have been altered in various agricultural crops by metabolic engineering. Read More

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http://dx.doi.org/10.1071/FP12265DOI Listing
November 2013

Reactive oxygen species regulation and antioxidant defence in halophytes.

Funct Plant Biol 2013 Aug;40(9):832-847

Department of Biology, Faculty of Science, Ege University, Bornova 35100, Izmir, Turkey.

Production of reactive oxygen species (ROS), which are a by-product of normal cell metabolism in living organisms, is an inevitable consequence of aerobic life on Earth, and halophytes are no exception to this rule. The accumulation of ROS is elevated under different stress conditions, including salinity, due to a serious imbalance between their production and elimination. These ROS are highly toxic and, in the absence of protective mechanisms, can cause oxidative damage to lipids, proteins and DNA, leading to alterations in the redox state and further damage to the cell. Read More

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http://dx.doi.org/10.1071/FP12389DOI Listing

Does age matter under winter photoinhibitory conditions? A case study in stems and leaves of European mistletoe (Viscum album).

Funct Plant Biol 2015 Feb;42(2):175-185

Department of Plant Biology and Ecology, University of Basque country (UPV/EHU) Apdo 644, 48080 Bilbao, Spain.

European mistletoe (Viscum album L.) is a hemiparasitic plant with perennial leaves and photosynthetic stems easily discernible according to their age. These properties make V. Read More

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http://dx.doi.org/10.1071/FP14083DOI Listing
February 2015

Photoprotective and antioxidative mechanisms against oxidative damage in Fargesia rufa subjected to drought and salinity.

Funct Plant Biol 2017 Feb;44(3):302-311

Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China.

Drought and salinity are the two most common and frequently co-occurring abiotic stresses limiting plant productivity worldwide, yet it remains unclear whether bamboo species possess effective mechanisms to protect against oxidative damage caused by drought and salinity, either alone or in combination. In this study, we utilised Fargesia rufa Yi, a species important to forest carbon sequestration and endangered giant pandas, to evaluate physiological, biochemical and ultrastructural responses to drought, salinity and their combination. Under drought alone, F. Read More

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http://dx.doi.org/10.1071/FP16214DOI Listing
February 2017

Water deficit stress tolerance in chickpea is mediated by the contribution of integrative defence systems in different tissues of the plant.

Funct Plant Biol 2016 Oct;43(10):903-918

Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana-141004, India.

Drought induces heavy yield losses in chickpea (Cicer arietinum L.). Besides understanding the physiological and biochemical parameters contributing to drought tolerance, we need to understand the importance of one tissue in combatting drought stress-induced oxidative stress and influencing the antioxidative defence system in other tissues. Read More

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http://dx.doi.org/10.1071/FP16062DOI Listing
October 2016

In vivo and in vitro approaches demonstrate proline is not directly involved in the protection against superoxide, nitric oxide, nitrogen dioxide and peroxynitrite.

Funct Plant Biol 2016 Sep;43(9):870-879

Laboratorio de Bioquímica, Departamento de Biología Vegetal, Facultad de Agronomía, Universidad de la República, Av. Gral. E. Garzón 809, Montevideo 12900, Uruguay.

Plants accumulate proline under diverse types of stresses, and it has been suggested that this α-amino acid has the capacity to protect against oxidative stress. However, it is still controversial whether its protection is due to the direct scavenging of reactive oxygen species (ROS). To solve this issue and considering that nitrosative stress is directly related with an oxidative stress condition, we evaluated whether proline can protect against nitrosative damage. Read More

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http://dx.doi.org/10.1071/FP16060DOI Listing
September 2016

Floating and submerged leaves of Potamogeton nodosus exhibit distinct variation in the antioxidant system as an ecophysiological adaptive strategy.

Funct Plant Biol 2016 Apr;43(4):346-355

Department of Environmental Studies, University of Delhi, Delhi - 110007, India.

During evaluations of the ecophysiological adaptations of floating and submerged leaves of Potamogeton nodosus Poir, investigations were carried to assess their antioxidant status. Floating leaves possessed a significantly higher level of C skeletons per unit of area compared with submerged leaves as they possessed greater PSI and PSII activity (hence had superior potential to harness absorbed light energy and generate assimilatory power) and carboxylase activity of Rubisco (hence superior potential to fix CO2) compared with the latter. Interestingly, submerged leaves possessed ~2 times higher H2O2 levels compared with floating leaves. Read More

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http://dx.doi.org/10.1071/FP15293DOI Listing

Rutin, a flavonoid with antioxidant activity, improves plant salinity tolerance by regulating K retention and Na exclusion from leaf mesophyll in quinoa and broad beans.

Funct Plant Biol 2015 Feb;43(1):75-86

School of Land and Food and Tasmanian Institute for Agriculture, University of Tasmania, Private Bag 54, Hobart, Tas. 7001, Australia.

The causal relationship between salinity and oxidative stress tolerance is well established, but specific downstream targets and the role of specific antioxidant compounds in controlling cellular ionic homeostasis remains elusive. In this work, we have compared antioxidant profiles of leaves of two quinoa genotypes contrasting in their salt tolerance, with the aim of understanding the role of enzymatic and non-enzymatic antioxidants in salinity stress tolerance. Only changes in superoxide dismutase activity were correlated with plant adaptive responses to salinity. Read More

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http://dx.doi.org/10.1071/FP15312DOI Listing
February 2015

The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction.

Biomed Pharmacother 2020 May 30;128:110259. Epub 2020 May 30.

Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.

Moringa Oleifera (MO) is a herbal plant native to South Asia known for its anti-oxidative and anti-inflammatory properties. This study explored the protective effects of MO leaf extract (MOLE) against oxidative stress and hepatic and renal injuries caused by methotrexate (MTX) therapy. Mice received a single intraperitoneal injection of 20 mg/kg body weight MTX to induce hepatic and kidney injuries. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110259DOI Listing

Characterization of mechanisms involved in tolerance and accumulation of Cd in Biscutella auriculata L.

Ecotoxicol Environ Saf 2020 May 30;201:110784. Epub 2020 May 30.

Department of Biochemistry Cellular and Molecular Biology of Plants, Estación Experimental Del Zaidín, Consejo Superior de Investigaciones Científicas (CSIC), Profesor Albareda 1, 18008, Granada, Spain. Electronic address:

Biscutella auriculata L. is one of the rare species that is able to grow in a very contaminated mining area in Villamayor de Calatrava (Ciudad Real, Spain). In an effort to understand the mechanisms involved in the tolerance of this plant to high metal concentrations, we grew B. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110784DOI Listing

Hypersaline water from desalinization plants causes oxidative damage in Posidonia oceanica meadows.

Sci Total Environ 2020 May 22;736:139601. Epub 2020 May 22.

Research Group on Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, E-07122 Palma de Mallorca, Balearic Islands, Spain; CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122 Palma de Mallorca, Balearic Islands, Spain.

Posidonia oceanica is an endemic marine phanerogam of the Mediterranean Sea for that is very sensitive to the environmental changes, especially those related to human activities. The aim of this study was to evaluate the oxidative stress status of P. oceanica meadows exposed to spillage of hypersaline water from a desalination station by using biomarkers. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139601DOI Listing

The chemical composition of barley grain (Hordeum vulgare L.) landraces from the Canary Islands.

J Food Sci 2020 Jun 2. Epub 2020 Jun 2.

Área de Nutrición y Bromatología, Departamento de Ingeniería Química y Tecnología Farmacéutica, Universidad de La Laguna, Tenerife, Spain.

The proximate composition, total phenolics, antioxidant activity, minerals, and trace elements were determined in 42 barley landraces in order to highlight their nutritional potential and promote their cultivation. Two-row barley landraces had a higher average content of starch, protein, total phenolic compounds, and iron, when compared with six-row ones that presented higher mean ash and fiber concentrations. Additionally, the six-row barley landraces with strongly pigmented grains had lower zinc and manganese and higher protein mean concentrations than the whitish or lightly pigmented barley landraces. Read More

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http://dx.doi.org/10.1111/1750-3841.15144DOI Listing

The Antioxidant Defense System in Chinese Jujube Is Triggered to Cope with Phytoplasma Invasion.

Tree Physiol 2020 Jun 1. Epub 2020 Jun 1.

College of Life Science, Hebei Agricultural University, Baoding, 071000 China.

Reactive oxygen species (ROS) in plants increase dramatically under pathogen attack, and the antioxidant defense system is then triggered to protect the plant against the ROS. Jujube witches' broom disease (JWB) caused by phytoplasma is a destructive disease of Chinese jujube. The results of fluorescence-based measurement revealed that ROS was overproduced within jujube leaves after phytoplasma invasion. Read More

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http://dx.doi.org/10.1093/treephys/tpaa067DOI Listing

Flavonoid epimers from custard apple leaves, a rapid screening and separation by HSCCC and their antioxidant and hypoglycaemic activities evaluation.

Sci Rep 2020 Jun 1;10(1):8819. Epub 2020 Jun 1.

Key Laboratory of TCM Quality Control, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China.

Leaves of custard apple are widely used in many places as a popular dietary supplement for the treatment of diabetes. Flavonoids are known to have anti-diabetic activity. In this study, the main flavonoid epimers were separated. Read More

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http://dx.doi.org/10.1038/s41598-020-65769-5DOI Listing

Effect of Different Antioxidants on X-ray Induced DNA Double-strand Breaks Using γ-H2AX in Human Blood Lymphocytes.

Health Phys 2020 Jul;119(1):101-108

Military Medical Research Center, Bucharest, Romania.

Ionizing radiation exposure produces direct or indirect biological effects on genomic DNA. The latter are ionizing radiation mediated by induction of free radicals and oxygen species (ROS). The study was conducted to evaluate the dose-effect/time-effect of antioxidant treatments in reducing the induction of double-strand breaks in human blood lymphocytes. Read More

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http://dx.doi.org/10.1097/HP.0000000000001267DOI Listing

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish ().

Int J Mol Sci 2020 May 28;21(11). Epub 2020 May 28.

Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, Sharjah P.O. Box 27272, UAE.

Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Read More

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http://dx.doi.org/10.3390/ijms21113838DOI Listing

Metabolic regulations in lettuce root under combined exposure to perfluorooctanoic acid and perfluorooctane sulfonate in hydroponic media.

Sci Total Environ 2020 Jul 14;726:138382. Epub 2020 Apr 14.

Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing 100044, China. Electronic address:

Per- and polyfluoroalkyl substances (PFASs) have been detected in many agricultural products in contaminated fields and in supply chains. Roots are the main organ in plants to uptake and bio-accumulate PFASs, but the changes of metabolic regulation in roots by PFASs are largely unexplored. Here, lettuce exposed to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) at different concentrations (500, 1000, 2000 and 5000 ng/L) was investigated via metabolomics. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138382DOI Listing

Biological markers to establish a relationship between the health status of the St. Lawrence River yellow perch (Perca flavescens) with a gradient of anthropogenic disturbances.

Sci Total Environ 2020 Jul 8;726:138515. Epub 2020 Apr 8.

Groupe de recherche en toxicologie de l'environnement (TOXEN), Département des sciences biologiques, Université du Québec à Montréal (UQAM), C.P. 8888, Succursale Centre-Ville, Montréal, QC H3C 3P8, Canada. Electronic address:

Since the mid-1990s, the decline of the yellow perch population of Lake Saint-Pierre (hereinafter LSP) in Quebec, Canada has been the subject of several research programs. The combined effect of habitat deterioration, the presence of invasive species, and poor water quality negatively affected the yellow perch population in this lake. In 2013, we sampled yellow perch (larvae, juveniles and adults) at six sites along the St. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.138515DOI Listing
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