569,924 results match your criteria Antioxidants & Redox Signaling[Journal]

Impacts of a nutrition education intervention in individuals with cardiometabolic risk: Protocol of a randomized controlled trial.

Clin Nutr ESPEN 2022 Jun 31;49:536-543. Epub 2022 Mar 31.

Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Background: Unhealthy dietary pattern including high dietary sugar intake is responsible for the cardiometabolic-related deaths. Nonetheless, adherence to the recommendation is low, and appropriate nutrition education to reduce sugar consumption is scarce.

Objective: This proposed project aims to evaluate the effectiveness of a nutrition education module in modifying sugar consumption and other cardiometabolic risk (CMR)-related outcomes in individuals with CMR. Read More

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A new hope: Mitochondria, a critical factor in the war against prions.

Mitochondrion 2022 May 24. Epub 2022 May 24.

Universidad San Francisco de Quito USFQ, Colegio de Ciencias de la Salud, Escuela de Medicina, 17-12-841, Quito, Ecuador; Mito-Act Research Consortium, Quito, Ecuador. Electronic address:

Prion diseases encompass a group of incurable neurodegenerative disorders that occur due to the misfolding and aggregation of infectious proteins. The most well-known prion diseases are Creutzfeldt-Jakob disease (CJD), bovine spongiform encephalopathy (also known as mad cow disease), and kuru. It is estimated that around 1-2 persons per million worldwide are affected annually by prion disorders. Read More

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Phenolic acids and their carboxylate anions: Thermodynamics of primary antioxidant action.

Phytochemistry 2022 May 24:113254. Epub 2022 May 24.

Institute of Physical Chemistry and Chemical Physics, Slovak University of Technology in Bratislava, Radlinského 9, SK-812 37, Bratislava, Slovakia. Electronic address:

Phenolic acids represent naturally occurring antioxidants and play important role in free radicals scavenging. In this work, we have studied thermodynamics of the first step of primary antioxidant action for phenolic OH groups of benzoic and cinnamic acid derivatives, and their carboxylate anions. M06-2X/6-311++G (d,p) reaction enthalpies related to Hydrogen Atom Transfer (HAT), Single Electron Transfer - Proton Transfer (SET-PT), and Sequential Proton-Loss Electron-Transfer (SPLET) mechanisms were computed for model non-polar environment (benzene) and aqueous solution. Read More

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Hydrogen sulfide alleviates chilling injury in peach fruit by maintaining cell structure integrity via regulating endogenous HS, antioxidant and cell wall metabolisms.

Food Chem 2022 May 21;391:133283. Epub 2022 May 21.

College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.

Effects of hydrogen sulfide (HS) on chilling injury (CI), HS, antioxidant and cell-wall metabolisms of refrigerated peaches treated with HS and hypotaurine (HT, HS scavenger) were investigated in present study. Results revealed that HS treatment enhanced endogenous HS content, which was associated with increased related HS synthase enzymes activities, while HT showed the opposite results. Moreover, HS treatment induced the accumulation of ascorbic acid, glutathione and the enhancement of antioxidant enzymes activities compared to control and HT, contributing to lower hydrogen peroxide content and superoxide radical production. Read More

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A systematic review and meta-analysis on serum and salivary levels of total antioxidant capacity and C-reactive protein in oral lichen planus patients.

Arch Oral Biol 2022 May 10;140:105445. Epub 2022 May 10.

Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Objective: Oral lichen planus (OLP) is an inflammatory disease that total antioxidant capacity (TAC) and C-reactive protein (CRP) play an important role in its pathogenesis. In this meta-analysis, we compared the salivary and serum levels of TAC and CRP between OLP patients and controls.

Design: A comprehensive search was performed in four databases (PubMed, Scopus, Web of Science, and Cochrane Library). Read More

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Impact of Acute Blood Loss on Clinical, Hematological, Biochemical, and Oxidative Stress Variables in Sheep.

Vet Sci 2022 May 11;9(5). Epub 2022 May 11.

Department of Animal Science, Federal Rural University of the Semiarid Region, Av. Francisco Mota 572, Bairro Costa e Silva, Mossoró 59625-000, RN, Brazil.

Blood loss in sheep can have different causes and may result in anemia. We aimed to evaluate the clinical, hematological, and biochemical alterations and the oxidative stress generated by acute blood loss. Eighteen healthy sheep underwent phlebotomy to remove 40% of the blood volume and were evaluated clinically and by laboratory tests for clinical, biochemical, and blood gas variables and to assess oxidative stress before induction (T0), 30 min (T30 min), and 6 (T6 h), 12 (T12 h), and 24 h (T24 h) after blood loss. Read More

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Evaluation of Growth Performance, Nitrogen Balance and Blood Metabolites of Mutton Sheep Fed an Ammonia-Treated Aflatoxin B1-Contaminated Diet.

Toxins (Basel) 2022 May 23;14(5). Epub 2022 May 23.

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.

Experiments were conducted to evaluate the effects of an aflatoxin B1 (AFB1)-contaminated diet treated with ammonia on the diet detoxification and growth performance, nutrient digestibility, nitrogen utilization, and blood metabolites in sheep. Twenty-four female mutton sheep with an initial body weight of 50 ± 2.5 kg were randomly assigned to one of three groups: (1) control diet (C); (2) aflatoxin diet (T; control diet supplemented with 75 μg of AFB1/kg of dry matter); and (3) ammoniated diet (AT; ammoniated aflatoxin diet). Read More

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Bergenin alleviates Diabetic Retinopathy in STZ-induced rats.

Appl Biochem Biotechnol 2022 May 27. Epub 2022 May 27.

Department of Ophthalmology, Central Hospital Affiliated to Shandong First Medical University, No. 105, Jiefang Road, Shandong Province, Jinan City, 250013, China.

Diabetic retinopathy (DR) is the key cause of blindness and visual impairment in diabetes patients around the world. The high levels of oxidative stress in diabetes patients cause diabetic retinopathy. In addition to being an antioxidant, Bergenin also works as an immunosuppressant, an anti-inflammatory, and anticarcinogenic against hepatocarcinoma. Read More

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Differential response of copper nanoparticles and ionic copper on growth, chlorophyll fluorescence, oxidative stress, and antioxidant machinery of two paddy field cyanobacteria.

Ecotoxicology 2022 May 27. Epub 2022 May 27.

Ranjan Plant physiology and Biochemistry Laboratory, Department of Botany, University of Allahabad, Prayagraj, 211002, India.

The current study explored the role of ionic copper (CuCl; 0.2 µM and 1 µM) and synthesized copper nanoparticles (CuNPs; 0.2 mM and 1 mM) in the two paddy field cyanobacteria (Nostoc muscorum ATCC 27893 and Anabaena sp. Read More

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Extraction and Identification of Three New Visceral Peptides and Their Antioxidant Activity.

Mar Drugs 2022 Apr 27;20(5). Epub 2022 Apr 27.

Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

The viscera of with polypeptides, fatty acids, and amino acids are usually discarded during processing to food. In order to improve the utilization value of the viscera of and avoid resource waste, antioxidant polypeptides were isolated from the viscera of . First, a protein hydrolysate of (UUPH) was prepared by ultrasonic-assisted enzymatic hydrolysis, and the degree of hydrolysis was as high as 79. Read More

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Multi-Responsive Optimization of Novel pH-Sensitive Hydrogel Beads Based on Basil Seed Mucilage, Alginate, and Magnetic Particles.

Gels 2022 Apr 27;8(5). Epub 2022 Apr 27.

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan.

Conventional drug delivery systems often cause side effects and gastric degradation. Novel drug delivery systems must be developed to decrease side effects and increase the efficacy of drug delivery. This research aimed to fabricate hydrogel beads for use as a drug delivery system based on basil seed mucilage (BSM), sodium alginate (SA), and magnetic particles (MPs). Read More

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Nitrogen application alleviates salt stress by enhancing osmotic balance, ROS scavenging, and photosynthesis of rapeseed seedlings ().

Plant Signal Behav 2022 Dec;17(1):2081419

College of Agriculture, Shihezi University, Xinjiang, China.

Nitrogen application could alleviate salt stress on crops, but the specific physiological mechanism is still unclear. Therefore, in this study, a pot experiment was conducted to explore the effects of different application rates of nitrogen (0, 0.15, 0. Read More

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December 2022

Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes.

J Diabetes Res 2022 17;2022:6796470. Epub 2022 May 17.

Clinical Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Zaloška 7; SI-1000 Ljubljana, Slovenia.

Methods: 40 individuals with type 1 diabetes (average age of 44.7 ± 2.5 years) were randomized into four groups: (1) control (placebo), (2) empagliflozin 25 mg daily, (3) metformin 2000 mg daily, and (4) empagliflozin-metformin combination (25 mg and 2000 mg daily, respectively). Read More

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Propagation of age-related diseases due to the changes of lipid peroxide and antioxidant levels in elderly people: A narrative review.

Health Sci Rep 2022 May 23;5(3):e650. Epub 2022 May 23.

Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh.

Background And Aims: Lipid peroxidation end products are the major culprit for inducing chronic diseases in elderly people. Along with the elevated level of lipid peroxide biomarkers, there is a significant disruption of antioxidants balance, which combinedly propagate the diseases of elderly people. The aim of the present review is to bridge the connection of changes in lipid peroxides biomarkers and antioxidants level with age-associated diseases in elderly people. Read More

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A Systematic Review on the Role of Antioxidants in Thyroid Eye Disease.

J Curr Ophthalmol 2022 Jan-Mar;34(1):16-24. Epub 2022 Apr 16.

Eye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To systematically review the role of antioxidants in management of patients with thyroid eye disease (TED).

Methods: A literature search of the electronic databases was performed without restrictions on the date of publication till the end of March 2021, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Clinical trials, case-control studies, cohorts, case series, case reports, and experimental (including ) studies in the English language were included. Read More

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Ferrocene-Containing Polymer via the Biginelli Reaction for In Vivo Treatment of Oxidative Stress Damage.

ACS Macro Lett 2019 Jun 23;8(6):639-645. Epub 2019 May 23.

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China.

Small molecule antioxidants have little impact on oxidative stress in vivo because of their poor bioavailability. To explore an antioxidant for in vivo applications, a polymeric antioxidant containing a ferrocene moiety was developed. The ferrocene-containing monomer was synthesized through the robust tricomponent Biginelli reaction with a high yield. Read More

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Mitochondrial Targeting Peptide-based Nanodelivery for Cancer Treatment.

Curr Protein Pept Sci 2022 May 20. Epub 2022 May 20.

The University of Kansas Medical Center, Cancer Biology, Kansas City, KS.

Mitochondria are important intracellular organelles because of their key roles in cellular metabolism, proliferation, and programmed cell death. The differences in the structure and function of the mitochondria of healthy and cancerous cells have made mitochondria an interesting target for drug delivery. Mitochondrial targeting is an emerging field as the targeted delivery of cytotoxic payloads and antioxidants to the mitochondrial DNA is capable of overcoming multidrug resistance. Read More

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Novel coumarin-functionalized inulin derivatives: Chemical modification and antioxidant activity assessment.

Carbohydr Res 2022 May 20;518:108597. Epub 2022 May 20.

Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 264003, Shandong, China. Electronic address:

In this paper, a series of target derivatives were synthesized by introducing coumarin into inulin structure using three-step chemical modification, and their structures were characterized by FTIR, H NMR, and C NMR. At the same time, the antioxidant activities of inulin derivatives were determined, including DPPH-radical scavenging activity, superoxide-radical scavenging activity, PTIO-radical scavenging activity and reducing ability. The test results showed that the antioxidant activities of inulin derivatives containing coumarin were significantly increased. Read More

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Melatonin enhances the antioxidant capacity to rescue the honey bee Apis mellifera from the ecotoxicological effects caused by environmental imidacloprid.

Ecotoxicol Environ Saf 2022 May 24;239:113622. Epub 2022 May 24.

College of Life Sciences, Chongqing Normal University, Chongqing, China; Chongqing Key Laboratory of Microsporidia Infection and Control, China; The State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, China.

Imidacloprid severely poisons the nontarget insect honey bee Apis mellifera. Few treatments are available to mitigate the adverse effects of imidacloprid. The primary concern is that the molecular understanding of imidacloprid toxicity is not comprehensive enough. Read More

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Enzyme-assisted extraction of anthocyanins and other phenolic compounds from blackcurrant (Ribes nigrum L.) press cake: From processing to bioactivities.

Food Chem 2022 May 18;391:133240. Epub 2022 May 18.

Natural Resources Institute Finland (Luke), Biorefinery and Bioproducts, Production Systems Unit, Myllytie 1, FI- 31600 Jokioinen, Finland. Electronic address:

The effects of commercial enzymes (pectinases, cellulases, beta-1-3-glucanases, and pectin lyases) on the recovery of anthocyanins and polyphenols from blackcurrant press cake were studied considering two solid:solvent ratios (1:10 and 1:4 w/v). β-glucanase enabled the recovery of the highest total phenolic content - 1142 mg/100 g, and the extraction of anthocyanins was similar using all enzymes (∼400 mg/100 g). The use of cellulases and pectinases enhanced the extraction of antioxidants (DPPH - 1080 mg/100 g; CUPRAC - 3697 mg/100 g). Read More

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Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide.

J Hazard Mater 2022 May 18;436:129138. Epub 2022 May 18.

Department of Biology, University of Saskatchewan, Saskatoon S7N 5E2, Canada.

The aln-3 mutant overaccumulating allantoin and respective wild type (WT) strain of Arabidopsis thaliana were exposed to cadmium (Cd) or mercury (Hg) with or without nitric oxide (NO) donor (sodium nitroprusside, SNP) to study cross-talk, metabolic and oxidative changes between these nitrogen sources (organic vs. inorganic). The aln-3 accumulated over 10-fold more allantoin than WT with the effect of Cd and Hg differing in leaf and root tissue: aln-3 contained more ascorbic acid and phytochelatins when treated with Cd or Hg and more Cd in both organs. Read More

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Dose differentiation in elevated UV-B manifests variable response of carbon-nitrogen content with changes in secondary metabolites of Curcuma caesia Roxb.

Environ Sci Pollut Res Int 2022 May 26. Epub 2022 May 26.

Laboratory of Air Pollution and Global Climate Change, Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.

Despite acting as environmental stress, UV-B also plays a regulatory role in the plant's growth and secondary metabolism. UV-B-induced changes show variations between and among the species. The present study mainly focuses on variations in carbon and nitrogen contents and their relation with the phytochemical constituents of Curcuma caesia exposed to two different doses of UV-B (ambient ± elevated UV-B for 1 h (2. Read More

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Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review).

Mol Med Rep 2022 Jul 26;26(1). Epub 2022 May 26.

General Directorate of Scientific Research Center, Salahaddin University‑Erbil, Erbil, Kurdistan Region 44002, Iraq.

Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters that serve a role in regulating normal and pathological cellular activities. They can stimulate or inhibit cancer cell proliferation and invasion, as well as interfere with cancer cell responses to drug treatments. Understanding the molecular pathways governing the interactions between these gases and the tumor microenvironment can be utilized for the identification of a novel technique to disrupt cancer cell interactions and may contribute to the conception of effective and safe cancer therapy strategies. Read More

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Supplementation with kaempferol relieves oxidative stress and enhances development of early bovine embryos in vitro.

Reprod Domest Anim 2022 May 26. Epub 2022 May 26.

College of Veterinary Medicine, Northwest A & F University, Yangling, Shaanxi, PR China.

Oxidative stress (OS) has been considered the principle cause of developmental failure of early embryos cultured in vitro; therefore, the addition of antioxidants is very important for improving in vitro culture (IVC) systems. Various antioxidants have been tested for IVC systems, but most have exhibited some side effects. Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one, KAE) is a flavonoid with strong antioxidant activity and no obvious side effects. Read More

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Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-B Signaling Pathway.

Oxid Med Cell Longev 2022 16;2022:8652741. Epub 2022 May 16.

Department of Neurology, Hebei Medical University, Shijiazhuang, China.

Increasing evidence shows that oxidative stress and neuroinflammation play a crucial role in the pathology of vascular dementia (VD). Previously, we have found that Dl-3-n-butylphthalide (NBP) has antioxidant and anti-inflammatory activities in VD, whereas little is known about its mechanism. Therefore, the objective of our study was to explore the contribution of nuclear factor erythroid-2 related factor 2 (Nrf2) to NBP and its effects on anti-inflammatory activity in a mouse model of VD. Read More

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Peroxisomal Proteome Mining of Sweet Pepper ( L.) Fruit Ripening Through Whole Isobaric Tags for Relative and Absolute Quantitation Analysis.

Front Plant Sci 2022 9;13:893376. Epub 2022 May 9.

Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, Spanish National Research Council (CSIC), Granada, Spain.

Peroxisomes are ubiquitous organelles from eukaryotic cells characterized by an active nitro-oxidative metabolism. They have a relevant metabolic plasticity depending on the organism, tissue, developmental stage, or physiological/stress/environmental conditions. Our knowledge of peroxisomal metabolism from fruits is very limited but its proteome is even less known. Read More

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Role of Promising Secondary Metabolites to Confer Resistance Against Environmental Stresses in Crop Plants: Current Scenario and Future Perspectives.

Front Plant Sci 2022 9;13:881032. Epub 2022 May 9.

State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China.

Plants often face incompatible growing environments like drought, salinity, cold, frost, and elevated temperatures that affect plant growth and development leading to low yield and, in worse circumstances, plant death. The arsenal of versatile compounds for plant consumption and structure is called metabolites, which allows them to develop strategies to stop enemies, fight pathogens, replace their competitors and go beyond environmental restraints. These elements are formed under particular abiotic stresses like flooding, heat, drought, cold, etc. Read More

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Melatonin-Mediated Abiotic Stress Tolerance in Plants.

Front Plant Sci 2022 9;13:847175. Epub 2022 May 9.

College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, China.

Melatonin is a multi-functional molecule that is ubiquitous in all living organisms. Melatonin performs essential roles in plant stress tolerance; its application can reduce the harmful effects of abiotic stresses. Plant melatonin biosynthesis, which usually occurs within chloroplasts, and its related metabolic pathways have been extensively characterized. Read More

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GC-MS Profile, Antioxidant Activity, and In Silico Study of the Essential Oil from L. Leaves in the Presence of Mosquito Juvenile Hormone-Binding Protein (mJHBP) from .

Biomed Res Int 2022 16;2022:5601531. Epub 2022 May 16.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhur, 22511 El-Beheira, Egypt.

is a medicinal plant used as an anti-inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone-binding protein (mJHBP) from , of the essential oil from leaves. Read More

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Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae.

Front Nutr 2022 9;9:888360. Epub 2022 May 9.

Faculty of Biomedical Sciences and Medicine (FCBM), University of Algarve, Faro, Portugal.

Bone metabolic disorders such as osteoporosis are characterized by the loss of mineral from the bone tissue leading to its structural weakening and increased susceptibility to fractures. A growing body of evidence suggests that inflammation and oxidative stress play an important role in the pathophysiological processes involved in the rise of these conditions. As the currently available therapeutic strategies are often characterized by toxic effects associated with their long-term use, natural antioxidants and anti-inflammatory compounds such as polyphenols promise to be a valuable alternative for the prevention and treatment of these disorders. Read More

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