4,005 results match your criteria Antioxid. Redox Signal.[Journal]


Vascular Extracellular Matrix Remodeling and Hypertension.

Antioxid Redox Signal 2020 May 27. Epub 2020 May 27.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China.

The vascular extracellular matrix (ECM) not only provides mechanical stability but also manipulates vascular cell behaviors, which are crucial for vascular function and homeostasis. ECM remodeling, which alters vascular wall mechanical properties and exposes vascular cells to bioactive molecules, is involved in the development and progression of hypertension. This brief review summarized the dynamic changes in ECM components and their modification and degradation during hypertension and after antihypertensive treatment. Read More

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http://dx.doi.org/10.1089/ars.2020.8110DOI Listing

Persulfide signaling in stress-initiated CaM kinase response.

Antioxid Redox Signal 2020 May 28. Epub 2020 May 28.

Showa Pharmaceutical University, Pharmacology, 3-3165,, Higashi-tamagawa Gakuen, Tokyo, Machida, Japan, 194-8543;

Significance: Ca2+/calmodulin (CaM)-dependent protein kinases (CaMKs) are activated by the phosphorylation of a crucial threonine residue either by itself (CaMKII) or by upstream kinases, CaMK kinases (CaMKKs), (CaMKI and CaMKIV). CaMKs, present in most mammalian tissues, can phosphorylate many downstream targets, thereby regulating numerous cellular functions. Recent Advances: Aside from canonical post-translational modifications, cysteine-based redox switches in CaMKs affect their enzyme activities. Read More

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http://dx.doi.org/10.1089/ars.2020.8138DOI Listing

The Landscape of Coding and Non-coding RNAs in Platelets.

Antioxid Redox Signal 2020 May 28. Epub 2020 May 28.

King's College London, 4616, School of Cardiovascular Medicine & Sciences, 125 Coldharbour Lane, London, United Kingdom of Great Britain and Northern Ireland, SE5 9NU;

Significance: Levels of platelet non-coding RNAs are altered by disease, and non-coding RNAs may exert functions inside and outside of platelets. Their role in physiologic haemostasis and pathologic thrombosis remains to be explored. Recent Advances: The number of RNA classes identified in platelets has been growing in the last decade. Read More

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http://dx.doi.org/10.1089/ars.2020.8139DOI Listing

Staphylococcus aureus, antibiotic resistance, and the interaction with human neutrophils.

Antioxid Redox Signal 2020 May 28. Epub 2020 May 28.

National Institute of Allergy and Infectious Diseases Division of Intramural Research, 469049, Laboratory of Bacteriology, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana, United States, 59840;

Significance: Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The high burden of S. aureus among human and animal hosts, which includes asymptomatic carriage and infection, is coupled with a notorious ability of the microbe to become resistant to antibiotics. Read More

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http://dx.doi.org/10.1089/ars.2020.8127DOI Listing

Imaging and targeting coronary artery inflammation.

Antioxid Redox Signal 2020 May 27. Epub 2020 May 27.

University of Oxford, 6396, Radcliffe Department of Medicine, Oxford, United Kingdom of Great Britain and Northern Ireland;

Significance Coronary artery disease (CAD) continues to be a leading cause of morbidity and mortality across the world despite significant progress in prevention, diagnosis and treatment of atherosclerotic disease. Recent Advances The focus of the cardiovascular community has shifted towards seeking a better understanding of the inflammatory mechanisms driving residual CAD risk not modulated by current therapies. Significant progress has been achieved in revealing both pro-inflammatory and anti-inflammatory mechanisms, and how shift of the balance in favour of the former, can drive the development of disease. Read More

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http://dx.doi.org/10.1089/ars.2020.8128DOI Listing

Redox regulation of tolerogenic dendritic cells and regulatory T cells in the pathogenesis and therapy of autoimmunity.

Antioxid Redox Signal 2020 May 27. Epub 2020 May 27.

Institute for Biological Research , Immunology, Bulevar Despota Stefana 142, Belgrade, Serbia, 11060;

Significance: Autoimmune diseases are progressively affecting westernized societies, as the proportion of individuals suffering from autoimmunity is steadily increasing over the past decades. Understanding the role of reactive oxygen species (ROS) in modulation of the immune response in the pathogenesis of autoimmune disorders is of outmost importance. The focus of this review is the regulation of ROS production within tolerogenic dendritic cells (DC) and regulatory T (Treg) cells that have the essential role in the prevention of autoimmune diseases and significant potency in their therapy. Read More

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http://dx.doi.org/10.1089/ars.2019.7999DOI Listing

Particulate matter induces tissues oxinflammation: From mechanism to damage.

Antioxid Redox Signal 2020 May 22. Epub 2020 May 22.

Universidad de Buenos Aires, 28196, Facultad de Farmacia y Bioquimica, Catedra de Química General e Inorgánica, Ciudad de Buenos Aires, Buenos Aires, Ciudad de Buenos Aires, Argentina, 1053;

Significance: Oxidative stress and oxidative damage are central hypothetical mechanisms for the adverse effects of airborne particulate matter (PM). Activation of inflammatory cells capable of generating reactive oxygen and nitrogen species is another proposed damage pathway. Understanding the interplay between these responses can help us understand the adverse health effects attributed to breathing polluted air. Read More

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http://dx.doi.org/10.1089/ars.2019.8015DOI Listing

Honokiol bis-dichloroacetate is a selective allosteric inhibitor of the mitochondrial chaperone TRAP1.

Antioxid Redox Signal 2020 May 22. Epub 2020 May 22.

University of Padova, Biomedical Sciences, viale G. Colombo 3, Padova, Italy, 35131;

Introduction: TRAP1, the mitochondrial paralog of the Hsp90 family of molecular chaperones, is required for neoplastic growth in several tumor cell models, where it inhibits succinate dehydrogenase (SDH) activity, thus favoring bioenergetic rewiring, maintenance of redox homeostasis and orchestration of a HIF1α-mediated pseudohypoxic program. Development of selective TRAP1 inhibitors is instrumental for targeted development of anti-neoplastic drugs, but was hampered up to now by the high degree of homology among catalytic pockets of Hsp90 family members. The vegetal derivative honokiol and its lipophilic bis-dichloroacetate ester, honokiol DCA (HDCA), are small molecule compounds with antineoplastic activity. Read More

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http://dx.doi.org/10.1089/ars.2019.7972DOI Listing

MicroRNAs as master regulators of atherosclerosis: from pathogenesis to novel therapeutic options.

Antioxid Redox Signal 2020 May 14. Epub 2020 May 14.

Molecular Cardiology, Heart Center Bonn, Internal Medicine-II, University Hospital Bonn, Bonn, NRW, Germany;

Significance: Cardiovascular disease (CVD) remains the major cause of morbidity and mortality worldwide. Accumulating evidence indicates that atherosclerosis and its sequelae, coronary artery disease (CAD), contribute to the majority of cardiovascular deaths. Atherosclerosis is a chronic inflammatory disease of the arteries in which atherosclerotic plaques form within the vessel wall. Read More

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http://dx.doi.org/10.1089/ars.2020.8107DOI Listing

Pathogenic role of air pollution particulate matter in cardiometabolic disease: Evidence from mice and humans.

Antioxid Redox Signal 2020 May 13. Epub 2020 May 13.

Universitäts-Herzzentrum Freiburg Bad Krozingen GmbH, 9202, Cardiology and Angiology I, Freiburg, Germany.

Significance: Air pollution is a considerable global threat to human health that dramatically increases the risk for cardiovascular pathologies, such as atherosclerosis, myocardial infarction, and stroke. An estimated 4.2 million cases of premature deaths worldwide are attributable to outdoor air pollution. Read More

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http://dx.doi.org/10.1089/ars.2020.8096DOI Listing

Roles of Perivascular adipose tissue in hypertension and atherosclerosis.

Antioxid Redox Signal 2020 May 10. Epub 2020 May 10.

University of Michigan, Internal Medicine, Cardiovascular Center, , Ann Arbor, Michigan, United States;

Significance: Perivascular adipose tissue (PVAT), which is present surrounding most blood vessels, from the aorta to the microvasculature of the dermis, is mainly composed of fat cells, fibroblasts, stem cells, mast cells and nerve cells. Although the PVAT is objectively present, its physiological and pathological significance has long been ignored. Recent Advances: PVAT was considered as a supporting component of blood vessels and a protective cushion to the vessel wall from the neighboring tissues during relaxation and contraction. Read More

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http://dx.doi.org/10.1089/ars.2020.8103DOI Listing

INTESTINAL DYSBIOSIS AND DEVELOPMENT OF CARDIOMETABOLIC DISORDERS IN CHILDHOOD CANCER SURVIVORS: A CRITICAL REVIEW.

Antioxid Redox Signal 2020 May 10. Epub 2020 May 10.

Research Centre, CHU Ste-Justine, Nutrition, Université de Montréal, 3175, Ste-Catherine Road, Montreal, Quebec, Canada, H3T 1C5.

Significance: Survivors of pediatric cancers have a high risk of developing side effects after the end of their treatments. Many potential factors have been associated with the onset of cardiometabolic disorders (CMD), including cancer disease itself, chemotherapy, hormonal treatment, radiotherapy and genetics. However, the precise etiology and underlying mechanisms of these long-term complications are poorly understood. Read More

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http://dx.doi.org/10.1089/ars.2020.8102DOI Listing

Reductive Stress - Neglected Science.

Antioxid Redox Signal 2020 May 7. Epub 2020 May 7.

University of Alabama at Birmingham, Pathology, 901 19th St South, BMR2-RM#533, Cardiac Aging and Redox Signaling Laboratory, Birmingham, Alabama, United States, 35294.

Over the past six decades, the concept of "redox" was focused on one arm of the redox spectrum; oxidative stress. In fact, a vast majority of experimental and clinical studies addressing redox mechanisms claimed "oxidative stress" as the culprit for acute or chronic disease conditions. Recent studies have documented that reactive oxygen species (ROS) are crucial signaling molecules facilitating various cellular processes. Read More

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http://dx.doi.org/10.1089/ars.2020.8114DOI Listing

Nitrate Respiration Promotes Polymyxin B Resistance in .

Antioxid Redox Signal 2020 May 28. Epub 2020 May 28.

Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Gyeonggi-do, Korea.

Polymyxin B (PMB) is known to require reactive oxygen species (ROS) for its bactericidal activity, but the mechanism of PMB resistance in various strains has been poorly understood. This study examined the role of nitrate respiration (NR) of some strains in the PMB resistance. We observed that the minimum inhibitory concentration (MIC) value of PMB against PA14 was eightfold reduced (from 2. Read More

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http://dx.doi.org/10.1089/ars.2019.7924DOI Listing

SG1002 AND CATENATED DIVALENT ORGANIC SULFUR COMPOUNDS AS PROMISING HYDROGEN SULFIDE PRODRUGS.

Antioxid Redox Signal 2020 May 6. Epub 2020 May 6.

Sulfagenix, Inc., Tucson, Arizona, United States.

Sulfur has a critical role in protein structure/function and redox status/signaling in all living organisms. Although hydrogen sulfide (H2S) and sulfane sulfur (SS) are now recognized as central players in physiology and pathophysiology, the full scope and depth of sulfur metabolome's impact on human health and healthy longevity has been vastly underestimated and is only starting to be grasped. Since many pathological conditions have been related to abnormally low levels of H2S/SS in blood and/ or tissues, and are amenable to treatment by H2S supplementation, development of safe and efficacious H2S donors deserves to be undertaken with a sense of urgency; these prodrugs also hold the promise of becoming widely used for disease prevention and as antiaging agents. Read More

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http://dx.doi.org/10.1089/ars.2020.8060DOI Listing

Endogenous and exogenous antioxidants as a tool to ameliorate male infertility induced by reactive oxygen species.

Antioxid Redox Signal 2020 May 5. Epub 2020 May 5.

University of Porto Institute of Biomedical Sciences Abel Salazar, 89239, Rua de Jorge Viterbo Ferreira n.º 228,, Porto, N/A, Portugal, 4050-313.

Significance: Antioxidants are essential for the maintenance of cellular redox homeodynamics in the male reproductive tract, playing a key role in fertilizing potential. Reactive oxygen species (ROS), at physiological levels, are essential for sperm function and fertilization. Under pathological conditions, abnormal production of ROS may occur. Read More

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http://dx.doi.org/10.1089/ars.2019.7977DOI Listing

Stable and temporary enzyme complexes and metabolons involved in energy and redox metabolism.

Antioxid Redox Signal 2020 May 5. Epub 2020 May 5.

MPIMP Golm, 1, Max-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany, 14476;

Significance: Alongside well-characterized permanent multimeric enzymes and multi-enzyme complexes relatively unstable transient enzyme-enzyme assemblies, including metabolons, provide an important mechanism for the regulation of energy and redox metabolism.

Critical Issues: Despite the fact that enzyme-enzyme assemblies have been proposed for many decades and experimentally analyzed for at least 40 years there are very few pathways for which unequivocal evidence for the presence of metabolite channeling, the most frequently evoked reason for their formation, has been provided. Furthermore, in contrast to the stronger, permanent interactions for which a deep understanding of the subunit interface exists the mechanism(s) underlying transient enzyme-enzyme interactions remain poorly studied. Read More

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http://dx.doi.org/10.1089/ars.2019.7981DOI Listing

Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension.

Antioxid Redox Signal 2020 May 27. Epub 2020 May 27.

Center for Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.

Hypertension has major health consequences, which is associated with endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) signaling in the vasculature plays an important role in maintaining vascular homeostasis. Considering the importance of NO system, this review aims to provide a brief overview of the biochemistry of members of NO signaling, including GTPCH1 [guanosine 5'-triphosphate (GTP) cyclohydrolase 1], tetrahydrobiopterin (BH), and eNOS. Read More

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http://dx.doi.org/10.1089/ars.2020.8112DOI Listing
May 2020
7.407 Impact Factor

Omega-3 Polyunsaturated Fatty Acids: Versatile Roles in Blood Pressure Regulation.

Antioxid Redox Signal 2020 Apr 29. Epub 2020 Apr 29.

Tianjin Medical University, 12610, Department of Physiology and Pathophysiology, Tianjin, China;

Significance: Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich in n-3 polyunsaturated fatty acids (PUFAs) is beneficial for hypertension. Read More

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http://dx.doi.org/10.1089/ars.2020.8108DOI Listing
April 2020
7.407 Impact Factor

Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.

Antioxid Redox Signal 2020 Apr 29. Epub 2020 Apr 29.

Department of Cardiology, Fujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, China.

Significance: The kidney plays an important role in the long-term control of blood pressure. Oxidative stress is one of the fundamental mechanisms responsible for the development of hypertension. Dopamine, via five subtypes of receptors, plays an important role in the control of blood pressure by various mechanisms including the inhibition of oxidative stress. Read More

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http://dx.doi.org/10.1089/ars.2020.8106DOI Listing

GLYCOMACROPEPTIDE: A BIOACTIVE MILK DERIVATIVE TO ALLEVIATE METABOLIC SYNDROME OUTCOMES.

Antioxid Redox Signal 2020 Apr 26. Epub 2020 Apr 26.

Research Centre, CHU Ste-Justine, Nutrition, Université de Montréal, 3175, Ste-Catherine Road, Montreal, Quebec, Canada, H3T 1C5.

Significance: Metabolic syndrome (MetS) represents a cluster of cardiometabolic disorders, which accelerate the risk of developing diabetes, non-alcoholic fatty liver disease and cardiovascular disorders such as atherosclerosis. Oxidative stress (OxS) and inflammation contribute to insulin resistance (IR) that greatly promote the clinical manifestations of MetS components. Given the growing prevalence of this multifactorial condition, its alerting comorbidities and the absence of specific drugs for treatment, there is an urgent need of prospecting for alternative nutraceutics as effective therapeutic agents for MetS. Read More

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http://dx.doi.org/10.1089/ars.2019.7994DOI Listing

Muscle Redox Signaling: Engaged in Sickness and in Health.

Antioxid Redox Signal 2020 May 18. Epub 2020 May 18.

Institut of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Even though physical activity is known to perturb the redox homeostasis and create a pro-oxidative muscular environment, robust evidence has confirmed precise, powerful, and beneficial effects of regular physical activity on health. Physical exercise can activate redox-sensitive intracellular signaling pathways reactive oxygen species (ROS)-related pathways leading to modification of muscle function through genomic and nongenomic mechanisms. However, ROS-mediated signaling also has deleterious effects on skeletal muscle function, which has been observed in several pathological conditions, such as cancer, obesity, and diabetes, among others. Read More

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http://dx.doi.org/10.1089/ars.2020.8095DOI Listing

High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction and impact on drug-resistant cells of anticancer thiosemicarbazones.

Antioxid Redox Signal 2020 Apr 25. Epub 2020 Apr 25.

Medical University of Vienna Institute of Cancer Research, 89097, Wien, Austria.

Aims: Due to their significant biological activity, thiosemicarbazones (TSC) are promising candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to chelate essential metal ions such as copper and iron. Triapine, the best studied anticancer TSC, has been tested clinically with promising results in hematological diseases. Read More

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http://dx.doi.org/10.1089/ars.2019.7854DOI Listing

Is There an Association Between Atherosclerotic Burden, Oxidative Stress, and Gut-Derived Lipopolysaccharides?

Antioxid Redox Signal 2020 May 18. Epub 2020 May 18.

Division I Medical Clinic, Department of Clinical, Internistic, Anaesthetic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Recent studies hypothesized a role of gut microbiota favoring atherosclerosis an increased oxidative stress, but data in peripheral artery disease (PAD) have not been provided yet. The aim of this study was to assess serum lipopolysaccharide (LPS) as well as oxidative stress in PAD patients and controls (CT). Furthermore, we wanted to analyze the relationship between LPS and the severity of atherosclerosis in the lower limb arteries. Read More

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http://dx.doi.org/10.1089/ars.2020.8109DOI Listing

Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit.

Antioxid Redox Signal 2020 May 19. Epub 2020 May 19.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Current treatment options for ovarian clear cell carcinoma (OCCC) are limited to combination of platinum-based and other cytotoxic agents to which patients respond poorly due to intrinsic chemoresistance. There is therefore an urgent need to develop alternative therapeutic strategies for OCCC. Cysteine deprivation suppresses OCCC growth and with no apparent toxicity. Read More

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http://dx.doi.org/10.1089/ars.2019.7850DOI Listing

Dihydrotanshinone I attenuates plaque vulnerability in ApoE-/- mice: role of RIP3.

Antioxid Redox Signal 2020 Apr 23. Epub 2020 Apr 23.

University of Macau, Institute of Chinese Medical Sciences, Avenida da Universidade, Taipa, MACAU, Macao;

Aims: Vulnerable plaque disruption in advanced atherosclerosis leads to acute thrombus and subsequent myocardial infarction and severely threatens human health. Necroptosis of macrophage involved in the necrotic core is one key factor for plaque vulnerability. Dihydrotanshinone I (DHT) is a natural diterpenoid isolated from Danshen demonstrating effective anti-inflammatory property. Read More

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http://dx.doi.org/10.1089/ars.2019.7796DOI Listing

Is Low Alveolar Type II Cell in the Lungs of Elderly Linked to the Observed Severity of COVID-19?

Antioxid Redox Signal 2020 May 8. Epub 2020 May 8.

Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Human lungs single-cell RNA sequencing data from healthy donors (elderly and young; GEO accession no. GSE122960) were analyzed to isolate and specifically study gene expression in alveolar type II cells. Colocalization of angiotensin-converting enzyme 2 () and enables severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) to enter the cells. Read More

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http://dx.doi.org/10.1089/ars.2020.8111DOI Listing
May 2020
7.407 Impact Factor

Interplay Between Oxidative Stress, Cyclooxygenases, and Prostanoids in Cardiovascular Diseases.

Antioxid Redox Signal 2020 May 15. Epub 2020 May 15.

Heart and Vascular Institute and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.

Endothelial cells lining the lumen of blood vessels play an important role in the regulation of cardiovascular functions through releasing both vasoconstricting and vasodilating factors. The production and function of vasoconstricting factors are largely elevated in hypertension, diabetes, atherosclerosis, and ischemia/reperfusion injuries. Cyclooxygenases (COXs) are the major enzymes producing five different prostanoids that act as either contracting or relaxing substances. Read More

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http://dx.doi.org/10.1089/ars.2020.8105DOI Listing

PULMONARY NEUTROPHILIC INFLAMMATION AND NON-COMMUNICABLE DISEASES: PATHOPHYSIOLOGY, REDOX MECHANISMS, BIOMARKERS AND THERAPEUTICS.

Antioxid Redox Signal 2020 Apr 22. Epub 2020 Apr 22.

CONICET San Luis, 376145, LABORATORY OF EXPERIMENTAL THERAPEUTICS AND NUTRITION , San Luis, San Luis, Argentina.

Significance: Neurophilic pulmonary inflammation (PNI) is the homming and activation of neutrophil with damage to the microvasculature. This process is involved in pulmonary damage in patients exposed to airborne pollutants (exogenous stressors) and also to systemic inflammation/oxidative stress (endogenous stressors)-associated to non-communicable diseases (NCD). Recent Advances: PNI is an important trigger of the early onset and progression of NCD in susceptible patients exposed to airborne pollutants. Read More

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http://dx.doi.org/10.1089/ars.2020.8098DOI Listing

The Role and Mechanism of Intestinal Flora in Blood Pressure Regulation and Hypertension Development.

Antioxid Redox Signal 2020 May 14. Epub 2020 May 14.

State Key Laboratory of Cardiovascular Disease of China, Hypertension Center, National Center for Cardiovascular Diseases of China, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Hypertension (HTN) has a complex etiology that is characterized by genetic and environmental factors. It has become a global health burden leading to cardiovascular diseases and kidney diseases, ultimately progressing to premature death. Accumulating evidence indicated that gut microbiome was associated with metabolic disorders and inflammation, which were closely linked to HTN. Read More

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http://dx.doi.org/10.1089/ars.2020.8104DOI Listing

Nitrosopersulfide (SSNO) Is a Unique Cysteine Polysulfidating Agent with Reduction-Resistant Bioactivity.

Antioxid Redox Signal 2020 May 19. Epub 2020 May 19.

Department of Molecular Immunology and Toxicology, National Institute of Oncology, Budapest, Hungary.

The aim of the present study was to investigate the biochemical properties of nitrosopersulfide (SSNO), a key intermediate of the nitric oxide (NO)/sulfide cross talk. We obtained corroborating evidence that SSNO is indeed a major product of the reaction of S-nitrosothiols with hydrogen sulfide (HS). It was found to be relatively stable (t ∼1 h at room temperature) in aqueous solution of physiological pH, stabilized by the presence of excess sulfide and resistant toward reduction by other thiols. Read More

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http://dx.doi.org/10.1089/ars.2020.8049DOI Listing

Hypoxic-Ischemic Encephalopathy and Mitochondrial Dysfunction: Facts, Unknowns and Challenges.

Antioxid Redox Signal 2020 Apr 16. Epub 2020 Apr 16.

Universidad de la Republica Facultad de Medicina, 54795, Departamento de Bioquimica, Montevideo, Uruguay.

Significance: Hypoxic ischemic events due to intrapartum complications represent the second cause of neonatal mortality and initiates an acute brain disorder known as hypoxic ischemic encephalopathy (HIE). In HIE, the brain undergoes primary and secondary energy failure phases separated by a latent phase in which partial neuronal recovery is observed. A hypoxic ischemic event leads to oxygen restriction causing ATP depletion, neuronal oxidative stress and cell death. Read More

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http://dx.doi.org/10.1089/ars.2020.8093DOI Listing

Chronic Empaglifozin treatment reduces myocardial infarct size in non-diabetic mice through STAT-3 mediated protection on microvascular endothelial cells and reduction of oxidative stress.

Antioxid Redox Signal 2020 Apr 16. Epub 2020 Apr 16.

National and Kapodistrian University of Athens, Laboratory of Pharmacology, Panepistimiopolis, Zografou, Athens, Athens, Greece, 15771.

Aims: Empagliflozin (EMPA) demonstrates cardioprotective effects on diabetic myocardium but its infarct sparing effects in normoglyceamia remain unspecified. We investigated the acute and chronic effect of EMPA on infarct size (IS) after ischemia-reperfusion injury (I/R) and the mechanisms of cardioprotection in non-diabetic mice.

Results: Chronic oral administration of EMPA (6 weeks) reduced myocardial IS after 30min/2h I/R (29. Read More

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http://dx.doi.org/10.1089/ars.2019.7923DOI Listing

Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.

Antioxid Redox Signal 2020 May 27. Epub 2020 May 27.

Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Selenoprotein P functions as a redox protein through its intrinsic thioredoxin domain and by distributing selenium to intracellular glutathione peroxidases, that is, glutathione peroxidase 1 and 4. : Selenoprotein P was rediscovered as a hepatokine that causes the pathology of type 2 diabetes and aging-related diseases, including exercise resistance in the skeletal muscle, insulin secretory failure in pancreatic β cells, angiogenesis resistance in vascular endothelial cells, and myocardial ischemicreperfusion injury. It was unexpected for the antioxidant selenoprotein P to cause insulin resistance, because oxidative stress associated with obesity and fatty liver is a causal factor for hepatic insulin resistance. Read More

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http://dx.doi.org/10.1089/ars.2020.8087DOI Listing

Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency.

Antioxid Redox Signal 2020 May 11. Epub 2020 May 11.

Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, United Kingdom.

Generalized selenoprotein deficiency has been associated with mutations in , , and , 3 factors that are crucial for incorporation of the amino acid selenocysteine (Sec) into at least 25 human selenoproteins. and defects are characterized by a multisystem phenotype due to deficiencies of antioxidant and tissue-specific selenoproteins, together with abnormal thyroid hormone levels reflecting impaired hormone metabolism by deiodinase selenoenzymes. mutations are associated with a predominantly neurological phenotype with progressive cerebello-cerebral atrophy. Read More

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http://dx.doi.org/10.1089/ars.2020.8097DOI Listing

Mycobacterial and human nitrobindins: structure and function.

Antioxid Redox Signal 2020 Apr 16. Epub 2020 Apr 16.

Roma Tre University, 19012, Department of Sciences, Roma, Italy;

Aims: Nitrobindins (Nbs) are evolutionary conserved all-β-barrel heme-proteins displaying a highly solvent-exposed heme-Fe(III) atom. The physiological role(s) of Nbs is almost unknown. Here, the structural and functional properties of the Mycobacterium tuberculosis Nb (Mt-Nb(III)) and Homo sapiens Nb (Hs-Nb(III)) have been investigated and compared with those of Arabidopsis thaliana Nb (At-Nb(III), of the hematophagous bug Rodius prolixus nitrophorins (Rp-NP(III)s), and of mammalian myoglobins. Read More

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http://dx.doi.org/10.1089/ars.2019.7874DOI Listing

Dual role of hydrogen peroxide as an oxidant in pneumococcal pneumonia.

Antioxid Redox Signal 2020 Apr 13. Epub 2020 Apr 13.

Augusta University Medical College of Georgia, 160343, Vascular Biology Center, Pharmacology and Toxicology, Pulmonary and Critical Care Medicine, Augusta, Georgia, United States;

Significance. Streptococcus pneumoniae (Spn), a facultative anaerobic Gram-positive human pathogen with increasing rates of penicillin and macrolide resistance, is a major cause of lower respiratory tract infections worldwide. Pneumococci are a primary agent of severe pneumonia in children under five years of age and of community acquired pneumonia (CAP) in adults. Read More

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http://dx.doi.org/10.1089/ars.2019.7964DOI Listing

Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction.

Antioxid Redox Signal 2020 May 8. Epub 2020 May 8.

Department of Neurosurgery, Bijie First People's Hospital, Bijie, China.

Traumatic brain injury (TBI) is a major cause of disability and death, and a better understanding of the underlying mechanisms of mitochondrial dysfunction will provide important targets for preventing damage from neuronal insults. Phosphoglycerate mutase 5 (PGAM5) is localized to the mitochondrial outer-inner membrane contact sites, and the PGAM5-Drp1 pathway is involved in mitochondrial dysfunction and cell death. The purpose of this project was to evaluate the effects of PGAM5 on neuronal injury and mitochondrial dysfunction. Read More

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http://dx.doi.org/10.1089/ars.2019.7982DOI Listing

Vitamin K2 alleviates insulin resistance in skeletal muscle by improving mitochondrial function via SIRT1 signaling.

Antioxid Redox Signal 2020 Apr 7. Epub 2020 Apr 7.

Fourth Military Medical University, 12644, Department of Nutrition and Food Hygiene, Xi'an, China.

Aims: High-fat diet (HFD)-induced insulin resistance (IR) impairs skeletal muscle mitochondrial biogenesis and functions, adversely affecting human health and lifespan. Vitamin K2 (VK2) has a beneficial role in improving insulin sensitivity and glucose metabolism. However, the underlying molecular mechanisms of VK2 on insulin sensitivity have not been well established. Read More

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http://dx.doi.org/10.1089/ars.2019.7908DOI Listing
April 2020
7.407 Impact Factor

Environmental Factors Such as Noise and Air Pollution and Vascular Disease.

Antioxid Redox Signal 2020 May 7. Epub 2020 May 7.

Center of Cardiology 1, Molecular Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany.

According to the World Health Organization, noncommunicable diseases are the globally leading cause of mortality. About 71% of 56 million deaths that occurred worldwide are due to noncommunicable cardiovascular risk factors, including tobacco smoking, unhealthy diets, lack of physical activity, overweight, arterial hypertension, diabetes, and hypercholesterolemia, which can be either avoided or substantially reduced. Thus, it is estimated that 80% of premature heart disease, stroke, and diabetes can be prevented. Read More

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http://dx.doi.org/10.1089/ars.2020.8090DOI Listing

Dietary restriction and oxidative stress: friends or enemies?

Antioxid Redox Signal 2020 Apr 3. Epub 2020 Apr 3.

National Hellenic Research Foundation, 54574, Athens, Greece;

Significance: It is well established that lifestyle and dietary habits have a tremendous impact on lifespan, the rate of aging and the onset/progression of age-related diseases. Specifically, dietary restriction (DR) and other healthy dietary patterns are usually accompanied by physical activity and differ to Western diet which is rich in fat and sugars. Moreover, as the generation of reactive oxidative species is the major causative factor of aging, while DR could modify the level of oxidative stress, therefore it has been proposed that DR increases both survival and longevity. Read More

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http://dx.doi.org/10.1089/ars.2019.7959DOI Listing
April 2020
7.407 Impact Factor

The Redox-Metabolic Couple of T Lymphocytes: Potential Consequences for Hypertension.

Antioxid Redox Signal 2020 Apr 30. Epub 2020 Apr 30.

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

T lymphocytes, as part of the adaptive immune system, possess the ability to activate and function in extreme cellular microenvironments, which requires these cells to remain highly malleable. One mechanism in which T lymphocytes achieve this adaptability is by responding to cues from both reactive oxygen and nitrogen species, as well as metabolic flux, which together fine-tune the functional fate of these adaptive immune cells. To date, examinations of the redox and metabolic effects on T lymphocytes have primarily investigated these biological processes as separate entities. Read More

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http://dx.doi.org/10.1089/ars.2020.8042DOI Listing

The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy.

Antioxid Redox Signal 2020 May 6. Epub 2020 May 6.

Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Although preeclampsia (PE) has been attributed to excessive oxidative stress (OS) in the placenta, mild antioxidants failed to prevent PE in clinical trials. As mitochondria are a major source of OS, this study assessed the potential of a potent mitochondria-targeting antioxidant MitoQ in the prevention of PE. Placentas from women with PE and from reduced uterine perfusion pressure (RUPP) mice demonstrated significantly higher OS, along with increased mitochondrial damage and compromised glutathione peroxidase (GPx) activities. Read More

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http://dx.doi.org/10.1089/ars.2019.7891DOI Listing
May 2020
7.407 Impact Factor

From Development to Aging: The Path to Cellular Senescence.

Antioxid Redox Signal 2020 May 5. Epub 2020 May 5.

Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia, Rome, Italy.

Senescence is a cellular state induced by internal or external stimuli, which result in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality as well as the senescence-associated secretory phenotype. Senescent cells accumulate in tissues in physiological and pathological conditions such as development, tissue repair, aging, and cancer. Growing evidences indicate that senescent cells are a heterogeneous cell population due to different cell-autonomous activated pathways and distinct microenvironmental contexts. Read More

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http://dx.doi.org/10.1089/ars.2020.8071DOI Listing

Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-κB and Nrf2/Keap-1 Signaling.

Antioxid Redox Signal 2020 Apr 23. Epub 2020 Apr 23.

Department of Clinical Pharmacotherapeutics, School of Pharmacy, Zunyi Medical University, Zunyi, China.

Neuroinflammation and oxidative stress are deemed the prime causes of brain injury after cerebral ischemia/reperfusion (I/R). Since the silent mating-type information regulation 2 homologue 3 (Sirt3) pathway plays an imperative role in protecting against neuroinflammation and oxidative stress, it has been verified as a target to treat ischemia stroke. Therefore, we attempted to seek novel Sirt3 agonist and explore its underlying mechanism for stroke treatment both and . Read More

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http://dx.doi.org/10.1089/ars.2019.7825DOI Listing
April 2020
7.407 Impact Factor

Muscle Disuse Atrophy Caused by Discord of Intracellular Signaling.

Antioxid Redox Signal 2020 Apr 28. Epub 2020 Apr 28.

Departmet Physical Education, Inha University, Incheon, South Korea.

Regular contractile activity plays a critical role in maintaining skeletal muscle morphological integrity and physiological function. If the muscle is forced to stop contraction, such as during limb immobilization (IM), the IGF/Akt/mTOR signaling pathway that normally stimulates protein synthesis and inhibits proteolysis will be suppressed, whereas the FoxO-controlled catabolic pathways such as ubiquitin-proteolysis and autophagy/mitophagy will be activated and dominate, resulting in muscle fiber atrophy. Mitochondria occupy a central position in the regulation of both protein synthesis and degradation through several redox-sensitive pathways, including peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), mitochondrial fusion and fission proteins, mitophagy, and sirtuins. Read More

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http://dx.doi.org/10.1089/ars.2020.8072DOI Listing
April 2020
7.407 Impact Factor

Cell Senescence, DNA Damage, and Metabolism.

Antioxid Redox Signal 2020 May 14. Epub 2020 May 14.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Senescence is an essential biological process that blocks tumorigenesis, limits tissue damage, and aids embryonic development. However, once senescent cells accumulate in tissues during aging, they promote the development of age-related diseases and limit health span. Thus, it is essential to expand the boundaries of our knowledge about the mechanisms responsible for controlling cellular senescence. Read More

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http://dx.doi.org/10.1089/ars.2020.8043DOI Listing

Redox Signaling in Widespread Health Benefits of Exercise.

Antioxid Redox Signal 2020 Apr 23. Epub 2020 Apr 23.

Institut of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Exercise-induced reactive oxygen species (ROS) production activates multiple intracellular signaling pathways through genomic and nongenomic mechanisms that are responsible for the beneficial effects of exercise in muscle. Beyond the positive effect of exercise on skeletal muscle cells, other tissues such as white and brown adipose, liver, central nervous system, endothelial, heart, and endocrine organ tissues are also responsive to exercise. Crosstalk between different cells is essential to achieve homeostasis and to promote the benefits of exercise through paracrine or endocrine signaling. Read More

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http://dx.doi.org/10.1089/ars.2019.7949DOI Listing

Senescence in Post-Mitotic Cells: A Driver of Aging?

Antioxid Redox Signal 2020 Apr 27. Epub 2020 Apr 27.

Ageing Research Laboratories, Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Cell senescence was originally defined by an acute loss of replicative capacity and thus believed to be restricted to proliferation-competent cells. More recently, senescence has been recognized as a cellular stress and damage response encompassing multiple pathways or senescence domains, namely DNA damage response, cell cycle arrest, senescence-associated secretory phenotype, senescence-associated mitochondrial dysfunction, autophagy/mitophagy dysfunction, nutrient and stress signaling, and epigenetic reprogramming. Each of these domains is activated during senescence, and all appear to interact with each other. Read More

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http://dx.doi.org/10.1089/ars.2020.8048DOI Listing

Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases.

Antioxid Redox Signal 2020 Apr 24. Epub 2020 Apr 24.

Laboratory of Metabolism and Exercise (LaMetEx), Research Center in Physical Activity Health and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADEUP), Porto, Portugal.

The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. Read More

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http://dx.doi.org/10.1089/ars.2020.8075DOI Listing