Antimicrob Agents Chemother 2018 Jun 11. Epub 2018 Jun 11.
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
Fosfomycin inhibits MurA following uptake by the GlpT transporter of glycerol-3-phosphate in In , plasmid overexpression of the Tet38 efflux pump and a mutant resulted in increased MICs and decreased accumulation of fosfomycin, with MICs affected by glycerol-3-phosphate. In contrast, a mutant had a lower MIC and increased accumulation of fosfomycin, suggesting that Tet38 acts as an efflux transporter of fosfomycin. Read More