1,649,950 results match your criteria Antimicrobial agents and chemotherapy[Journal]


Kojic acid applications in cosmetic and pharmaceutical preparations.

Biomed Pharmacother 2018 Dec 8;110:582-593. Epub 2018 Dec 8.

Student Research Committee, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Skin color disorders can be caused by various factors, such as excessive exposure to sunlight, aging and hormonal imbalance during pregnancy, or taking some medications. Kojic acid (KA) is a natural metabolite produced by fungi that has the ability to inhibit tyrosinase activity in synthesis of melanin. The major applications of KA and its derivatives in medicine are based on their biocompatibility, antimicrobial and antiviral, antitumor, antidiabetic, anticancer, anti-speck, anti-parasitic, and pesticidal and insecticidal properties. Read More

View Article
December 2018
1 Read

Impact of a multimodal strategy combining a new standard of care and restriction of carbapenems, fluoroquinolones and cephalosporins, on antibiotic consumption and resistance of P.aeruginosa in an ICU.

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Service de maladies infectieuses, Centre hospitalier Sud Ile-de-France, 77000 Melun. Electronic address:

Objectives: To assess if the postprescription review and feedback (PPRF) of all antibiotics with restriction of carbapenems, fluoroquinolones and third generation cephalosporins, along with a change of medical standard of care, impacted the consumption of antibiotics and bacterial resistance in a medical/surgical intensive care unit (MSICU).

Methods: A four years before (2007-2010) and after (2011-2014) retrospective comparative study. Antibiotics consumption was evaluated in Defined Daily Doses per 1000 patient days. Read More

View Article
December 2018

Treatment of chronic osteomyelitis with multi-dose oritavancin: a case series and literature review.

Int J Antimicrob Agents 2018 Dec 8. Epub 2018 Dec 8.

Downtown Dublin Wound Center, Meadows Regional Medical Center, Dublin, GA, 31021, USA.

Osteomyelitis remains difficult to treat, typically requiring a prolonged course of intravenous (IV) antibiotics. The optimal route and duration of antibiotics remains ill-defined due to limited prospective clinical trials. Oritavancin is a long acting, semisynthetic, lipoglycopeptide antibiotic with rapid, concentration-dependent bactericidal activity against many Gram-positive organisms. Read More

View Article
December 2018

Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection.

J Ethnopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address:

Ethnopharmacological Relevance: The emergence of drug-resistant Mycobacterium tuberculosis (M.tb) strains has severely hampered global efforts towards tuberculosis (TB) eradication. The internationally accepted therapy "Directly Observed Treatment Short-course (DOTS)" is lengthy, and incorporates risks for the generation of drug-resistant M. Read More

View Article
December 2018
1 Read

Ciprofloxacin resistance among Campylobacter jejuni isolates obtained from shelter dogs in Texas.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Texas A&M University, College Station, Texas.

There are few epidemiologic studies on the shedding of Campylobacter among dogs in the United States, despite the potential public health implications. Our objectives were to estimate the prevalence of faecal Campylobacter shedding among Texas shelter dogs as detected by culture methods and to characterize the isolates by species and antimicrobial susceptibility. Using a cross-sectional study design, faecal samples were collected from 185 dogs in six animal shelters throughout Texas between May and December 2014. Read More

View Article
December 2018
1 Read

Bioengineering Nisin to overcome the Nisin Resistance Protein.

Mol Microbiol 2018 Dec 11. Epub 2018 Dec 11.

School of Microbiology, University College Cork, Cork, Ireland.

The emergence and dissemination of antibiotic resistant bacteria is a major medical challenge. Lantibiotics are highly modified bacterially produced antimicrobial peptides that have attracted considerable interest as alternatives or adjuncts to existing antibiotics. Nisin, the most widely studied and commercially exploited lantibiotic, exhibits high efficacy against many pathogens. Read More

View Article
December 2018
1 Read

Functional characterization of horizontally transferred 4,5-DOPA extradiol dioxygenase gene in the domestic silkworm, Bombyx mori.

Insect Mol Biol 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of Evolutionary and Functional Genomics, School of Life Sciences, Chongqing University, Chongqing, 401331, China.

4,5-DOPA dioxygenase (DODA) is a crucial enzyme in the biosynthetic pathway of betalain. Previous studies have shown that DODA is present in plants, fungi and bacteria. Using updated data, here, we show that DODA genes (BmDODA) in domestic silkworm (Bombyx mori) and other lepidopteran insects are most likely to be horizontally transferred from fungi. Read More

View Article
December 2018

LL-37 and its analog FF/CAP18 attenuate neutrophil migration in sepsis-induced acute lung injury.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Experimenter Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.

Introduction: Sepsis can result in acute lung injury. LL-37 is a small cationic host defense peptide involved in anti-inflammatory. In the current study, it was hypothesized that antimicrobial peptide LL-37 could play a protective role in attenuating the progression of sepsis-induced acute lung injury. Read More

View Article
December 2018

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review.

J Pharm Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Programa de Pós-graduação em Ciências Aplicadas à Saúde, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil.

Objectives: The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Read More

View Article
December 2018
1 Read

Biopharmaceutical Activities Related to Ellagic Acid, Chitosan, and Zein and Their Improvement by Association.

J Food Sci 2018 Dec;83(12):2970-2975

Dept. of Biological Sciences and Health, Federal Univ. of Amapa, Rod. Juscelino Kubitschek, Km-02 - Jardim Marco Zero, Macapá-AP, 68903-419, Brazil.

Ellagic acid (EA) has demonstrated several biological properties, such as antioxidant, antimicrobial, and enzymatic inhibition. Zein and chitosan (CHI) are natural polymers whose biological potential has also gained attention. Therefore, this paper aimed to evaluate the antimicrobial, antioxidant, anticollagenase, and antielastase properties of EA, zein, and chitosan isolated or in combination. Read More

View Article
December 2018

Ruxolitinib treatment for steroid refractory acute and chronic graft versus host disease in children: Clinical and immunological results.

Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.

Stem cell transplant unit, Avda. Menendez Pelayo n°65, Hospital Niño Jesús (Madrid).

Ruxolitinib is a promising treatment for steroid refractory graft-versus-host disease (GvHD). However, data concerning effects on T cells are probably involved in increased risk of opportunistic infections. We analyzed clinical and immunological changes in children with GvHD taking ruxolitinib. Read More

View Article
December 2018

Effects of the timing of administration of IgM- and IgA-enriched intravenous polyclonal immunoglobulins on the outcome of septic shock patients.

Ann Intensive Care 2018 Dec 10;8(1):122. Epub 2018 Dec 10.

Department of Anesthesia, Resuscitation and Pain Therapy, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy.

Background: The administration of endovenous immunoglobulins in patients with septic shock could be beneficial and preparations enriched with IgA and IgM (ivIgGAM) seem to be more effective than those containing only IgG. In a previous study Berlot et al. demonstrated that early administration of ivIgGAM was associated with lower mortality rate. Read More

View Article
December 2018

Antimicrobial susceptibility and molecular typing of Pasteurella multocida isolated from six provinces in China.

Trop Anim Health Prod 2018 Dec 10. Epub 2018 Dec 10.

Department of Basic Veterinary Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, Jilin, China.

Pasteurella multocida (P. multocida) is an important pathogen that causes bovine respiratory disease (BRD) in China and other countries. To investigate the antimicrobial susceptibility of P. Read More

View Article
December 2018

Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes.

J Antimicrob Chemother 2018 Dec 10. Epub 2018 Dec 10.

CIISA - Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Objectives: To characterize the population structure, antimicrobial resistance and virulence genes of Klebsiella spp. isolated from dogs, cats and humans with urinary tract infections (UTIs).

Methods: Klebsiella spp. Read More

View Article
December 2018

Characteristics of third-generation cephalosporin-resistant Salmonella from retail chicken meat produced by integrated broiler operations.

Poult Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Public Health, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.

Integrated broiler operations, which control and operate vertically through all phases of the chicken industry, have applied biosecurity and sanitation practices, housing technologies, feeding regimens, and antibiotic applications in different ways to improve food safety. The objective of this study was to compare the prevalence and antimicrobial resistance profiles of Salmonella isolates recovered from 6 different integrated broiler operations and to analyze the characteristics of extended-spectrum β-lactamase (ESBL)- and plasmid-mediated AmpC β-lactamase (pAmpC)-producing Salmonella isolates. Among 336 chicken meat samples, 57 were observed to be positive for Salmonella. Read More

View Article
December 2018

Epidemiology of Bloodstream Infections in Hospitalized Children in the United States, 2009-2016.

Clin Infect Dis 2018 Dec 9. Epub 2018 Dec 9.

Pediatric Emergency Medicine, Chief of Critical Care Services, Children's Minnesota, Minneapolis, MN, USA.

Background: Bloodstream infections (BSIs) cause significant morbidity and mortality in children. Recent pediatric epidemiological data may inform prevention strategies and empiric antimicrobial therapy selection.

Methods: We conducted a retrospective cohort study from 2009-2016 utilizing demographic and microbiology data on inpatients <19 years using the Premier Healthcare Database. Read More

View Article
December 2018

Antimicrobial resistance in Chile and The One Health paradigm: Dealing with threats to human and veterinary health resulting from antimicrobial use in salmon aquaculture and the clinic.

Rev Chilena Infectol 2018 ;35(3):299-308

Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.

The emergence and dissemination of antimicrobial-resistant bacteria (ARB) is currently seen as one of the major threats to human and animal public health. Veterinary use of antimicrobials in both developing and developed countries is many-fold greater than their use in human medicine and is an important determinant in selection of ARB. In light of the recently outlined National Plan Against Antimicrobial Resistance in Chile, our findings on antimicrobial use in salmon aquaculture and their impact on the environment and human health are highly relevant. Read More

View Article
January 2018

[Nosocomial urinary tract infection: an analysis beyond urinary catheterization].

Rev Chilena Infectol 2018 ;35(3):246-252

Servicio de Medicina Interna, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.

Introduction: Nosocomially acquired urinary tract infections (NAUTI) represent an important public health issue, but its characteristics when they are not catheter associated (CA-UTI) or when they take place outside intensive care units (ICU) are poorly understood.

Objectives: To determine the patients' characteristics, etiology and antimicrobial susceptibility of NAUTI, both CA-UTI and no CA-UTI, in general ward and ICU.

Methods: We conducted a retrospective analytic cross-sectional study, between 2009 and 2013, in a third level universitary hospital. Read More

View Article
January 2018

[Antimicrobial prophylaxis for transient bacteremia during dental procedures].

Rev Med Chil 2018 Jul;146(7):899-906

Facultad de Odontología, Universidad San Sebastián, Santiago, Chile.

This review examines the evidence about the relationship between dental procedures and the incidence of transient bacteremia. One of the main obstacles was to define "invasive dental procedure" as an indication for antimicrobial prophylaxis for patients with high risk of bacteremia. A search in WorldWideScience and ScienceDirect was performed and 20 articles were selected for review. Read More

View Article

Self-assembly dynamics and antimicrobial activity of all l- and d-amino acid enantiomers of a designer peptide.

Nanoscale 2018 Dec 10. Epub 2018 Dec 10.

MDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Recent studies have shown that antimicrobial peptides (AMPs) can self-assemble into supramolecular structures, but this has been overlooked as causative of their antimicrobial activity. Also, the higher antimicrobial potency of d-enantiomers compared to l-enantiomers of AMPs cannot always be attributed to their different resistance to protease degradation. Here, we tested all l- and d-amino acid versions of GL13K, an AMP derived from a human protein, to study structural links between the AMP secondary structure, supramolecular self-assembly dynamics, and antimicrobial activity. Read More

View Article
December 2018
7.394 Impact Factor

Sodium nitrite potentiates antimicrobial photodynamic inactivation: possible involvement of peroxynitrate.

Photochem Photobiol Sci 2018 Dec 11. Epub 2018 Dec 11.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA. and Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

We have recently shown that a wide range of different inorganic salts can potentiate antimicrobial photodynamic inactivation (aPDI) and TiO2-mediated antimicrobial photocatalysis. Potentiation has been shown with azide, bromide, thiocyanate, selenocyanate, and most strongly, with iodide. Here we show that sodium nitrite can also potentiate broad-spectrum aPDI killing of Gram-positive MRSA and Gram-negative Escherichia coli bacteria. Read More

View Article
December 2018

Hypericin photodynamic activity. Part III: in vitro evaluation in different nanocarriers against trypomastigotes of Trypanosoma cruzi.

Photochem Photobiol Sci 2018 Dec 10. Epub 2018 Dec 10.

Departamento de Química, Universidade Estadual de Maringá, 87020-900, Maringá, Paraná, Brazil.

Chagas is a parasitic endemic disease caused by the protozoan Trypanosoma cruzi. It represents a strong threat to public health due to its strong resistance against commonly available drugs. We studied the in vitro ability to inactivate the trypomastigote form of this parasite using photodynamic inactivation of microorganisms (or antimicrobial Photodynamic Therapy, aPDT). Read More

View Article
December 2018

Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates.

Commun Biol 2018 7;1:221. Epub 2018 Dec 7.

1Synthetic Biology Group, MIT Synthetic Biology Center; The Center for Microbiome Informatics and Therapeutics; Research Laboratory of Electronics, Department of Biological Engineering, and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

Antimicrobial peptides (AMPs) constitute promising alternatives to classical antibiotics for the treatment of drug-resistant infections, which are a rapidly emerging global health challenge. However, our understanding of the structure-function relationships of AMPs is limited, and we are just beginning to rationally engineer peptides in order to develop them as therapeutics. Here, we leverage a physicochemical-guided peptide design strategy to identify specific functional hotspots in the wasp-derived AMP polybia-CP and turn this toxic peptide into a viable antimicrobial. Read More

View Article
December 2018

Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency.

Commun Biol 2018 7;1:220. Epub 2018 Dec 7.

Robert Frederick Smith School of Chemical and Biomolecular Engineering, 120 Olin Hall, Cornell University, Ithaca, NY 14853 USA.

Cationic charge and hydrophobicity have long been understood to drive the potency and selectivity of antimicrobial peptides (AMPs). However, these properties alone struggle to guide broad success in vivo, where AMPs must differentiate bacterial and mammalian cells, while avoiding complex barriers. New parameters describing the biophysical processes of membrane disruption could provide new opportunities for antimicrobial optimization. Read More

View Article
December 2018

The More the Merrier? Should Antibiotics be Used for Rhinoplasty and Septorhinoplasty?-A Review.

Plast Reconstr Surg Glob Open 2018 Oct 16;6(10):e1972. Epub 2018 Oct 16.

Department of Otolaryngology-Head and Neck Surgery, Division of Facial Plastic and Reconstructive Surgery, University of Southern California-Keck School of Medicine, Los Angeles, Calif.

Background: With antimicrobial resistance a global threat, optimizing antibiotic usage across the surgical continuum is vital. The American Academy of Otolaryngology-Head and Neck Surgery Foundation recently published the first guidelines addressing management in rhinoplasty. The authors reviewed pertinent literature on the role of systemic antibiotics in rhinoplasty and septorhinoplasty. Read More

View Article
October 2018

Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature.

Case Rep Infect Dis 2018 11;2018:9409121. Epub 2018 Nov 11.

University of Iowa, Department of Internal Medicine, Division of Infectious Diseases, Iowa City, IA, USA.

Infection with is a rare but often fatal complication in hematopoietic stem cell transplantation (HSCT) recipients. Most cases have been reported in allogeneic (allo-) HSCT recipients, with only narrative reports following autologous HSCT (ASCT). We report the case of a 58-year-old Caucasian male presenting with toxoplasma encephalitis following tandem ASCT for myeloma and successfully treated with diagnosis by polymerase chain reaction analysis of cerebrospinal fluid. Read More

View Article
November 2018

Impact of pre-travel consultation on clinical management and outcomes of travelers' diarrhea: a retrospective cohort study.

Trop Dis Travel Med Vaccines 2018 4;4:16. Epub 2018 Dec 4.

1Division of Infectious Diseases, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905 USA.

Background: International travelers are at high risk of acquiring travelers' diarrhea. Pre-travel consultation has been associated with lower rates of malaria, hepatitis, and human immunodeficiency virus (HIV) infections. The objective was to study the impact of pre-travel consultation on clinical management and outcomes of travelers' diarrhea. Read More

View Article
December 2018

Line-probe assay and molecular typing reveal a potential drug resistant clone of in Ethiopia.

Trop Dis Travel Med Vaccines 2018 4;4:15. Epub 2018 Dec 4.

1Armauer Hansen Research Institute, Jima Road, Addis Ababa, Ethiopia.

Background: Antimicrobial resistance is a global concern of increasing significance. Multidrug resistant tuberculosis (MDR-TB) is spreading worldwide. It is important to monitor trends of antimycobacterial resistance. Read More

View Article
December 2018

Attitude and perception of medical interns about antimicrobial resistance: a multi center cross-sectional study in Ethiopia.

Antimicrob Resist Infect Control 2018 4;7:149. Epub 2018 Dec 4.

School of Medicine, College of Medicine and Health Sciences, University of Gondar, P.O. Box: 196, Gondar, Ethiopia.

Background: Antibiotic resistance is a global burden and reduction of antimicrobial resistance requires change in antimicrobial prescribing behavior of health workers. The current study aimed to evaluate the attitude and perception of Ethiopian medical interns towards antimicrobials resistance.

Methods: A multi center cross-sectional institutional based survey was conducted from August 2016 to October 2016 among medical interns in Ethiopia. Read More

View Article
December 2018

Travel to Asia is a strong predictor for carriage of cephalosporin resistant and but does not explain everything; prevalence study at a Norwegian hospital 2014-2016.

Antimicrob Resist Infect Control 2018 29;7:146. Epub 2018 Nov 29.

1Department of Antibiotic Resistance and Infection Prevention, Norwegian Institute of Public Health, PO Box 222 Skøyen, 0213 Oslo, NO Norway.

Background: We aimed to estimate the prevalence of faecal carriage of extended-spectrum cephalosporin (ESC) resistant and (ESCr-EK) and vancomycin resistant enterococci (VRE) in patients upon hospital admission and identify factors associated with carriage to better target interventions and to guide empirical antibiotic treatment.

Methods: Between October 2014 and December 2016, we recruited patients admitted to a Norwegian university hospital. A rectal swab and questionnaire covering possible risk factors for colonisation were collected upon admission. Read More

View Article
November 2018

The acceptability of screening for Carbapenemase Producing (CPE): cross-sectional survey of nursing staff and the general publics' perceptions.

Antimicrob Resist Infect Control 2018 23;7:144. Epub 2018 Nov 23.

1School of Health & Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow, Scotland G4 0BA UK.

Background: Carbapenemase Producing (CPE) has spread rapidly and presents a growing challenge in antimicrobial resistance (AMR) management internationally. Screening for CPE may involve a rectal swab, there are limited treatment options for affected patients, and colonised patients are cared for in isolation to protect others. These measures are sound infection prevention precautions; however, the acceptability of CPE screening and its consequences are currently unknown. Read More

View Article
November 2018

Antimicrobial assay of combination surfactant irrigant regimen on vancomycin-resistant . An direct contact test.

Dent Res J (Isfahan) 2018 Nov-Dec;15(6):397-403

Department of Biochemistry, ABSMIDS, NITTE University, Mangaluru, Karnataka, India.

Background: Vancomycin-resistant enterococci (VRE) are on the rise globally in primary intraradicular infections and resistant to most intracanal irrigants and medicaments. The aim of this study was to evaluate the efficacy of irrigants and identify a cost-effective regimen to eradicate VRE.

Materials And Methods: In this study irrigants were categorized as primary and surfactant groups with individual concentrations consisting of 10 samples each. Read More

View Article
December 2018
1 Read

Effect of plant on decreasing the level of halitosis: A systematic review.

Dent Res J (Isfahan) 2018 Nov-Dec;15(6):379-384

Dental Students Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Tea is the second most consumed beverage. Polyphenolic catechins of green tea have a number of beneficial effects in oral cavity. This study aims to evaluate the clinical effects of green tea on halitosis through a systematic review of available literature. Read More

View Article
December 2018

Eosinophil Extracellular Traps and Inflammatory Pathologies-Untangling the Web!

Front Immunol 2018 26;9:2763. Epub 2018 Nov 26.

Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.

Eosinophils are an enigmatic white blood cell, whose immune functions are still under intense investigation. Classically, the eosinophil was considered to fulfill a protective role against parasitic infections, primarily large multicellular helminths. Although eosinophils are predominantly associated with parasite infections, evidence of a role for eosinophils in mediating immunity against bacterial, viral, and fungal infections has been recently reported. Read More

View Article
November 2018

Artificial Activation of and Toxin-Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy.

Front Microbiol 2018 26;9:2870. Epub 2018 Nov 26.

Centre of New Technologies, University of Warsaw, Warsaw, Poland.

The search for new, non-standard targets is currently a high priority in the design of new antibacterial compounds. Bacterial toxin-antitoxin systems (TAs) are genetic modules that encode a toxin protein that causes growth arrest by interfering with essential cellular processes, and a cognate antitoxin, which neutralizes the toxin activity. TAs have no human analogs, are highly abundant in bacterial genomes, and therefore represent attractive alternative targets for antimicrobial drugs. Read More

View Article
November 2018

Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats.

Front Mol Neurosci 2018 26;11:429. Epub 2018 Nov 26.

Physiology and Biophysics Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Triclosan, a widely used industrial and household agent, is present as an antiseptic ingredient in numerous products of everyday use, such as toothpaste, cosmetics, kitchenware, and toys. Previous studies have shown that human brain and animal tissues contain triclosan, which has been found also as a contaminant of water and soil. Triclosan disrupts heart and skeletal muscle Ca signaling, damages liver function, alters gut microbiota, causes colonic inflammation, and promotes apoptosis in cultured neocortical neurons and neural stem cells. Read More

View Article
November 2018

Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model.

Front Mol Neurosci 2018 26;11:378. Epub 2018 Nov 26.

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the brain. Previous studies have shown that mutations in the () gene cause a familial, fever-associated epilepsy syndrome. It is unclear as to whether the gene also correlates with other stimulations such as flashing and/or mediates the effects of antiepileptic drugs. Read More

View Article
November 2018

Complete Genome Sequences of Canadian Epidemic Methicillin-Resistant Staphylococcus aureus Strains CMRSA3 and CMRSA6.

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Centre for Antimicrobial Resistance, Alberta Health Services/Calgary Laboratory Services/University of Calgary, Calgary, Alberta, Canada.

Methicillin-resistant Staphylococcus aureus (MRSA) clonal complex 8 (CC8) sequence type 239 (ST239) represents a predominant hospital-associated MRSA sublineage present worldwide. The Canadian epidemic MRSA strains CMRSA3 and CMRSA6 are moderately virulent members of this group but are closely related to the highly virulent strain TW20. Whole-genome sequencing of CMRSA3 and CMRSA6 was conducted to identify genetic determinants associated with their virulence. Read More

View Article

Complete Genome Sequence of Acinetobacter radioresistens Strain LH6, a Multidrug-Resistant Bacteriophage-Propagating Strain.

Microbiol Resour Announc 2018 Aug 9;7(5). Epub 2018 Aug 9.

Department of Microbiology and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.

Antimicrobial resistance is a major problem worldwide. Understanding the interplay between drug-resistant pathogens, such as Acinetobacter baumannii and related species, potentially acting as environmental reservoirs is critical for preventing the spread of resistance determinants. Here we report the complete genome sequence of a multidrug-resistant bacteriophage-propagating strain of Acinetobacter radioresistens. Read More

View Article

Complete Genome Sequence of a Staphylococcus aureus Sequence Type 612 Isolate from an Australian Horse.

Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.

Curtin Health Innovation Research Institute and School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.

Staphylococcus aureus is a serious pathogen of humans and animals. Multilocus sequence type 612 is dominant and highly virulent in South African hospitals but relatively uncommon elsewhere. We present the complete genome sequence of methicillin-resistant Staphylococcus aureus strain SVH7513, isolated from a horse at a veterinary clinic in New South Wales, Australia. Read More

View Article

Draft Genome Sequences of Two Multidrug-Resistant Salmonella enterica Serovar Typhimurium Clinical Isolates from Uruguay.

Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.

Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, UDELAR, Montevideo, Uruguay.

Multidrug-resistant Salmonella enterica isolates are an increasing problem worldwide; nevertheless, the mechanisms responsible for such resistance are rarely well defined. Multidrug-resistant S. enterica serovar Typhimurium isolates ST3224 and ST827 were collected from two patients. Read More

View Article

Complete Genome Sequence of Pseudomonas aeruginosa K34-7, a Carbapenem-Resistant Isolate of the High-Risk Sequence Type 233.

Microbiol Resour Announc 2018 Aug 2;7(4). Epub 2018 Aug 2.

Centre for Integrative Microbial Evolution (CIME), Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Carbapenem-resistant Pseudomonas aeruginosa is defined as a "critical" priority pathogen for the development of new antibiotics. Here we report the complete genome sequence of an extensively drug-resistant, Verona integron-encoded metallo-β-lactamase-expressing isolate belonging to the high-risk sequence type 233. Read More

View Article

Genome Sequences of Actinobacteria from Extreme Environments in Colombia.

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Molecular Genetics, Corporación Corpogen-Research Center, Bogotá, Colombia.

We sequenced six actinobacterial genomes isolated from a salt mine and from soil in a high-mountain Páramo ecosystem. The strains belonged to the genera Streptomyces, Nesterenkonia, and Isoptericola and were sequenced due to their antimicrobial and cytotoxic activities. Read More

View Article
December 2018

Draft Genome Sequence of a Tetracycline-Resistant Plesiomonas shigelloides Strain Isolated from Aquaculture-Reared Tilapia.

Microbiol Resour Announc 2018 Jul 19;7(2). Epub 2018 Jul 19.

Laboratório de Investigação em Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

We hereby present the 3.7-Mb draft genome sequence of Plesiomonas shigelloides strain FM82, isolated from a tilapia (Oreochromis niloticus) reared in a fish farm in Rio de Janeiro, Brazil. P. Read More

View Article

Draft Genome Sequences of Violacein-Producing Duganella sp. Isolates from a Waterway in Eastern Pennsylvania.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Reem-Kayden Center for Science and Computation, Program of Biology, Bard College, Annandale-on-Hudson, New York, USA.

Five Duganella sp. bacterial isolates that synthesize violacein were cultured from a central Pennsylvania waterway. Violacein has antimicrobial potential, including chytrid-killing effects, relevant to amphibian declines worldwide. Read More

View Article
September 2018

Antimicrobial usage by pastoralists in food animals in North-central Nigeria: The associated socio-cultural drivers for antimicrobials misuse and public health implications.

One Health 2018 Dec 9;6:41-47. Epub 2018 Nov 9.

Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Nigeria.

Antimicrobials are used to maintain good health and productivity of food animals. Misuse of antibiotics in livestock contributes to development of antimicrobial resistance, an emerging One Health issue. This study assessed pastoralists' knowledge and practices regarding antimicrobial usage, explore pathways for resistant pathogens emergence and associated social drivers for antimicrobial misuse in pastoral herds of North-central Nigeria. Read More

View Article
December 2018

Prevalence and Antimicrobial Susceptibility Profile of Serovars Isolated from Slaughtered Cattle in Addis Ababa, Ethiopia.

Biomed Res Int 2018 4;2018:9794869. Epub 2018 Nov 4.

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.

is one of the top causes of foodborne bacterial illnesses in humans. The primary sources of human infection are food producing animals such as cattle, poultry, and swine. A cross-sectional study was undertaken to estimate the prevalence and to determine the serovar distribution and antimicrobial susceptibility profiles of spp. Read More

View Article
November 2018

The plasmid-encoded transcription factor ArdK contributes to the repression of the IMP-6 metallo-β-lactamase gene blaIMP-6, leading to a carbapenem-susceptible phenotype in the blaIMP-6-positive Escherichia coli strain A56-1S.

PLoS One 2018 11;13(12):e0208976. Epub 2018 Dec 11.

Pathogen Genomics Center, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.

Carbapenemase-producing Enterobacteriaceae (CPE) are a global concern because these bacteria are resistant to almost all β-lactams. Horizontal interspecies gene transfer via plasmid conjugation has increased the global dissemination of CPE. Recently, an Enterobacteriaceae strain positive for carbapenemase gene but showing a carbapenem-susceptible phenotype was identified, suggesting that these susceptible strains may be challenging to detect solely via antimicrobial susceptibility tests without molecular analysis. Read More

View Article
December 2018

Antimicrobial Effects of Egyptian Local Chicory, subsp.

Authors:
Ahmed M Amer

Int J Microbiol 2018 4;2018:6475072. Epub 2018 Nov 4.

Department of Plant Biotechnology, National Research Centre (NRC), Cairo 12622, Egypt.

The discovery of novel and more efficient antimicrobial agents from natural sources like plants is one of the most important ways through which the growing threat of antibiotic-resistant pathogens can be overcome. Herein, we report the potential antimicrobial activity of L. subsp. Read More

View Article
November 2018
  • Page 1 of 32999