818 results match your criteria Antimicrobial Resistance And Infection Control[Journal]


Mechanisms affecting the implementation of a national antimicrobial stewardship programme; multi-professional perspectives explained using normalisation process theory.

Antimicrob Resist Infect Control 2020 Jul 2;9(1):99. Epub 2020 Jul 2.

Glasgow Caledonian University, Glasgow, UK.

Background: Antimicrobial stewardship (AMS) describes activities concerned with safe-guarding antibiotics for the future, reducing drivers for the major global public health threat of antimicrobial resistance (AMR), whereby antibiotics are less effective in preventing and treating infections. Appropriate antibiotic prescribing is central to AMS. Whilst previous studies have explored the effectiveness of specific AMS interventions, largely from uni-professional perspectives, our literature search could not find any existing evidence evaluating the processes of implementing an integrated national AMS programme from multi-professional perspectives. Read More

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http://dx.doi.org/10.1186/s13756-020-00767-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330968PMC

The impact of antimicrobial stewardship program implementation at four tertiary private hospitals: results of a five-years pre-post analysis.

Antimicrob Resist Infect Control 2020 29;9:95. Epub 2020 Jun 29.

Research Center, Dr Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia.

Background: Antimicrobial stewardship (AMS) programs have shown to reduce the emergence of antimicrobial resistance (AMR) and health-care-associated infections (HAIs), and save health-care costs associated with an inappropriate antimicrobial use. The primary objective of this study was to compare the consumption and cost of antimicrobial agents using defined daily dose (DDD) and direct cost of antibiotics before and after the AMS program implementation. Secondary objective was to determine the rate of HAIs [ (), ventilator-associated pneumonia (VAP), and central line-associated bloodstream infection (CLABSI) before and after the AMS program implementation. Read More

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http://dx.doi.org/10.1186/s13756-020-00751-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322716PMC

The association of a reduced susceptibility to moxifloxacin in causative Clostridium (Clostridioides) difficile strain with the clinical outcome of patients.

Antimicrob Resist Infect Control 2020 Jun 30;9(1):98. Epub 2020 Jun 30.

Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.

Objectives: To investigate the relationship between Clostridium (Clostridioides) difficile strain characteristics and C. difficile infection (CDI) outcome.

Methods: Between October and December 2017, 16 hospitals collected epidemiological data according to the European Centre for Disease Prevention and Control (ECDC) surveillance protocol for CDI. Read More

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http://dx.doi.org/10.1186/s13756-020-00765-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325081PMC

Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries.

Antimicrob Resist Infect Control 2020 Jun 30;9(1):97. Epub 2020 Jun 30.

HIV/STI Unit, Institute of Tropical Medicine, 2000, Antwerp, Belgium.

Background: It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae.

Methods: We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. Read More

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http://dx.doi.org/10.1186/s13756-020-00764-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325135PMC

Effect of urine reflex culturing on rates of cultures and infections in acute and long-term care.

Antimicrob Resist Infect Control 2020 Jun 29;9(1):96. Epub 2020 Jun 29.

Department of Infection Control, VA Maryland Health Care System, Baltimore, MD, USA.

Background: Urine cultures are often positive in the absence of a urinary tract infection (UTI). Pyuria is generally considered necessary to diagnose a UTI.

Problem: Urine cultures are often positive in the absence of UTI leading to unnecessary antibiotics. Read More

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http://dx.doi.org/10.1186/s13756-020-00762-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325138PMC

The impact of antimicrobial stewardship program implementation at four tertiary private hospitals: results of a five-years pre-post analysis.

Antimicrob Resist Infect Control 2020 Jun 29;9(1):95. Epub 2020 Jun 29.

Research Center, Dr Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia.

Background: Antimicrobial stewardship (AMS) programs have shown to reduce the emergence of antimicrobial resistance (AMR) and health-care-associated infections (HAIs), and save health-care costs associated with an inappropriate antimicrobial use. The primary objective of this study was to compare the consumption and cost of antimicrobial agents using defined daily dose (DDD) and direct cost of antibiotics before and after the AMS program implementation. Secondary objective was to determine the rate of HAIs [Clostridium difficile (C. Read More

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http://dx.doi.org/10.1186/s13756-020-00751-4DOI Listing

First report of plasmid-mediated colistin resistance mcr-8.1 gene from a clinical Klebsiella pneumoniae isolate from Lebanon.

Antimicrob Resist Infect Control 2020 Jun 26;9(1):94. Epub 2020 Jun 26.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos Campus, P.O. Box 36, Byblos, Lebanon.

Colistin is considered as a last resort treatment for infections caused by multidrug-resistant Enterobacteriaceae. Plasmid-mediated mobile colistin resistance (mcr) genes contributed to the global spread of colistin resistance. This is the first report of plasmid-mediated colistin resistance mcr-8 gene from a clinical Klebsiella pneumoniae K9 isolate recovered from Lebanon. Read More

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http://dx.doi.org/10.1186/s13756-020-00759-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318401PMC

Poor infection prevention and control standards are associated with environmental contamination with carbapenemase-producing and other multidrug-resistant bacteria in Swiss companion animal clinics.

Antimicrob Resist Infect Control 2020 23;9:93. Epub 2020 Jun 23.

Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Background: Intensive medical care in companion animal clinics could pose a risk for the selection and dissemination of multidrug-resistant organisms (MDROs). Infection prevention and control (IPC) concepts are key measures to reduce the spread of MDROs, but data on IPC standards in companion animal clinics is sparse. The study assessed IPC standards in seven companion animal clinics and practices in Switzerland by structured IPC audits and combined results with environmental MDRO contamination and MDRO carriage of the personnel. Read More

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http://dx.doi.org/10.1186/s13756-020-00742-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310346PMC

Poor infection prevention and control standards are associated with environmental contamination with carbapenemase-producing Enterobacterales and other multidrug-resistant bacteria in Swiss companion animal clinics.

Antimicrob Resist Infect Control 2020 Jun 23;9(1):93. Epub 2020 Jun 23.

Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Background: Intensive medical care in companion animal clinics could pose a risk for the selection and dissemination of multidrug-resistant organisms (MDROs). Infection prevention and control (IPC) concepts are key measures to reduce the spread of MDROs, but data on IPC standards in companion animal clinics is sparse. The study assessed IPC standards in seven companion animal clinics and practices in Switzerland by structured IPC audits and combined results with environmental MDRO contamination and MDRO carriage of the personnel. Read More

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http://dx.doi.org/10.1186/s13756-020-00742-5DOI Listing

Evaluating infection prevention and control programs in Austrian acute care hospitals using the WHO Infection Prevention and Control Assessment Framework.

Antimicrob Resist Infect Control 2020 Jun 22;9(1):92. Epub 2020 Jun 22.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Hygiene and Environmental Medicine, Berlin, Germany.

Background: Infection prevention and control (IPC) is crucial for patient safety. The World Health Organization (WHO) has released various tools to promote IPC. In 2018, the WHO released the Infection Prevention and Control Assessment Framework (IPCAF) that enables acute care healthcare facilities to evaluate IPC structures and practices. Read More

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http://dx.doi.org/10.1186/s13756-020-00761-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309981PMC

Successful control of the first carbapenem-resistant Klebsiella pneumoniae outbreak in a Chinese hospital 2017-2019.

Antimicrob Resist Infect Control 2020 Jun 22;9(1):91. Epub 2020 Jun 22.

Department of Pharmacy, Second Hospital of Shanxi Medical University, No 382, Wuyi Road, Xinghualing District, Taiyuan, Shanxi, People's Republic of China.

Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered as a serious global threat. CRKPs occurred only sporadically in the Second Hospital of Shanxi Medical University. Our study aimed to investigate and control the first outbreak of CRKP in our hospital occurred between October 2017 and August 2019. Read More

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http://dx.doi.org/10.1186/s13756-020-00757-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310137PMC

Critical Reliability Issues of Common Type Alcohol-Based Handrub Dispensers.

Antimicrob Resist Infect Control 2020 Jun 22;9(1):90. Epub 2020 Jun 22.

University Research and Innovation Center (EKIK), Óbuda University, Budapest, Hungary.

Background: Hand hygiene can only be efficient if the whole hand surface is treated with sufficient alcohol-based handrub (ABHR); therefore, the volume of handrub applied is a critical factor in patient safety. The proper amount of ABHR should be provided by handrub dispensers. The aim of this study was to investigate the dispensing performance of wall-mounted ABHR dispensers commonly employed in hospital settings. Read More

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http://dx.doi.org/10.1186/s13756-020-00735-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310242PMC

The epidemiology of carbapenem-non-susceptible Acinetobacter species in Europe: analysis of EARS-Net data from 2013 to 2017.

Antimicrob Resist Infect Control 2020 Jun 19;9(1):89. Epub 2020 Jun 19.

Department 3: Infectious Disease Epidemiology, Unit 37: Healthcare-associated Infections, Surveillance of Antibiotic Resistance and Consumption, Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany.

Background: Due to limited therapeutic options and their association with high mortality and morbidity, carbapenem-non-susceptible Acinetobacter spp. (CNA) are of significant public health importance. This study aimed to describe current epidemiological trends of CNA proportions in Europe and to identify factors that are associated with carbapenem non-susceptibility of isolates from patients with invasive Acinetobacter spp. Read More

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http://dx.doi.org/10.1186/s13756-020-00750-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304165PMC

Proposal for a EN 149 acceptable reprocessing method for FFP2 respirators in times of severe shortage.

Antimicrob Resist Infect Control 2020 06 17;9(1):88. Epub 2020 Jun 17.

Federal Office for Civil Protection FOCP, Spiez Laboratory, Spiez, Switzerland.

Introduction: Transmission of SARS-CoV-2 to health care workers (HCW) poses a major burden in the current COVID-19 pandemic. Unprotected exposure to a COVID-19 patient is a key risk factor for HCWs. Transmission mainly occurs by droplet transmission, or by aerosol generating procedures. Read More

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http://dx.doi.org/10.1186/s13756-020-00744-3DOI Listing

Proposal for a EN 149 acceptable reprocessing method for FFP2 respirators in times of severe shortage.

Antimicrob Resist Infect Control 2020 17;9:88. Epub 2020 Jun 17.

Federal Office for Civil Protection FOCP, Spiez Laboratory, Spiez, Switzerland.

Introduction: Transmission of SARS-CoV-2 to health care workers (HCW) poses a major burden in the current COVID-19 pandemic. Unprotected exposure to a COVID-19 patient is a key risk factor for HCWs. Transmission mainly occurs by droplet transmission, or by aerosol generating procedures. Read More

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http://dx.doi.org/10.1186/s13756-020-00744-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298450PMC

Prevention of severe infectious complications after colorectal surgery using oral non-absorbable antimicrobial prophylaxis: results of a multicenter randomized placebo-controlled clinical trial.

Antimicrob Resist Infect Control 2020 15;9:84. Epub 2020 Jun 15.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Surgical site infections (SSIs) are common complications after colorectal surgery. Oral non-absorbable antibiotic prophylaxis (OAP) can be administered preoperatively to reduce the risk of SSIs. Its efficacy without simultaneous mechanical cleaning is unknown. Read More

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http://dx.doi.org/10.1186/s13756-020-00745-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294517PMC

A silent outbreak of vancomycin-resistant Enterococcus faecium in a neonatal intensive care unit.

Antimicrob Resist Infect Control 2020 Jun 16;9(1):87. Epub 2020 Jun 16.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: To describe the containment of a widespread silent outbreak of vancomycin-resistant Enterococcus faecium (VRE-fm) in the Tel-Aviv Medical Center (TASMC) neonatal intensive care unit (NICU).

Methods: Setting - an NICU, participants - 49 cases of VRE-fm-colonized neonatal inpatients.

Results: A newborn was transferred from the TASMC NICU to another hospital and screened positive for VRE-fm upon arrival. Read More

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http://dx.doi.org/10.1186/s13756-020-00755-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298964PMC

Hand hygiene in surgery in Benin: opportunities and challenges.

Antimicrob Resist Infect Control 2020 Jun 15;9(1):85. Epub 2020 Jun 15.

Clinical Pharmacy Research Group (CLIP), Louvain Drug Research Institute (LDRI), Université catholique de Louvain UCLouvain, Brussels, Belgium.

Background: Hand Hygiene (HH) has been described as the cornerstone and starting point in all infection control. Compliance to HH is a fundamental quality indicator. The aim of this study was to investigate the HH compliance among Health-care Workers (HCWs) in Benin surgical care units. Read More

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http://dx.doi.org/10.1186/s13756-020-00748-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296752PMC

Prevention of severe infectious complications after colorectal surgery using oral non-absorbable antimicrobial prophylaxis: results of a multicenter randomized placebo-controlled clinical trial.

Antimicrob Resist Infect Control 2020 Jun 15;9(1):84. Epub 2020 Jun 15.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Surgical site infections (SSIs) are common complications after colorectal surgery. Oral non-absorbable antibiotic prophylaxis (OAP) can be administered preoperatively to reduce the risk of SSIs. Its efficacy without simultaneous mechanical cleaning is unknown. Read More

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http://dx.doi.org/10.1186/s13756-020-00745-2DOI Listing

Will healthcare workers improve infection prevention and control behaviors as COVID-19 risk emerges and increases, in China?

Antimicrob Resist Infect Control 2020 06 11;9(1):83. Epub 2020 Jun 11.

Present address: School of Medicine and Health Management, Tongji Medical School, Huazhong University of Science and Technology, No.13 Hangkong Rd, Wuhan, Hubei Province, China.

Background: COVID-19 arise global attention since their first public reporting. Infection prevention and control (IPC) is critical to combat COVID-19, especially at the early stage of pandemic outbreak. This study aimed to measure level of healthcare workers' (HCW') self-reported IPC behaviors with the risk of COVID-19 emerges and increases. Read More

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http://dx.doi.org/10.1186/s13756-020-00746-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289224PMC

Prevalence of Candida auris in Canadian acute care hospitals among at-risk patients, 2018.

Antimicrob Resist Infect Control 2020 Jun 10;9(1):82. Epub 2020 Jun 10.

National Microbiology Laboratory, Public Health Agency of Canada, H5050 - 1015 Arlington St, Winnipeg, MB, R3E 3R2, Canada.

To identify the prevalence of C. auris in Canadian patients who are potentially at risk for colonization, we screened 488 patients who were either hospitalized abroad, had a carbapenemase-producing organism (CPO), or were in units with high antifungal use. Two patients were colonized with C. Read More

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http://dx.doi.org/10.1186/s13756-020-00752-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288437PMC

Challenges regarding the control of environmental sources of contamination in healthcare settings in low-and middle-income countries - a narrative review.

Antimicrob Resist Infect Control 2020 Jun 9;9(1):81. Epub 2020 Jun 9.

Infection Control Africa Network, Cape Town, South Africa.

Background: Healthcare-associated infections (HAI) especially outbreaks of multi-drug-resistant organisms within hospitals are recognized as a major contributor to morbidity and mortality of hospitalized patients. The healthcare environment can act as an amplifier of HAI during outbreaks. The risk of acquiring HAI are 20 times higher in Low-and-middle-income countries. Read More

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http://dx.doi.org/10.1186/s13756-020-00747-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285732PMC

Impact of hand hygiene intervention: a comparative study in health care facilities in Dodoma region, Tanzania using WHO methodology.

Antimicrob Resist Infect Control 2020 Jun 8;9(1):80. Epub 2020 Jun 8.

Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P. O. Box 1464, Mwanza, Bugando, Tanzania.

Background: Compliance with guidelines on hand hygiene (HH) is pivotal to prevent and control health-care associated infections and contributes to mitigating antimicrobial resistance. A baseline assessment in Dodoma region, Tanzania in March 2018 showed inadequate HH levels across health care facilities. We evaluated the impact of training in HH as part of a water, sanitation and hygiene (WASH) interventions of "Maji kwa Afya ya Jamii" (MKAJI) project. Read More

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http://dx.doi.org/10.1186/s13756-020-00743-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282123PMC

Five-year change of prevalence and risk factors for infection and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary hospital in North China.

Antimicrob Resist Infect Control 2020 Jun 1;9(1):79. Epub 2020 Jun 1.

Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215 Heping Western Road, Shijiazhuang, 050000, China.

Background: There are few studies focused on carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection (BSI). The aim of this study is to identify the prevalence and risk factors for infection and mortality of CRKP BSI.

Methods: Susceptibility of Klebsiella pneumoniae (KP) isolated from blood samples and the proportion of CRKP were recorded annually. Read More

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http://dx.doi.org/10.1186/s13756-020-00728-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268443PMC

One Health in hospitals: how understanding the dynamics of people, animals, and the hospital built-environment can be used to better inform interventions for antimicrobial-resistant gram-positive infections.

Antimicrob Resist Infect Control 2020 Jun 1;9(1):78. Epub 2020 Jun 1.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, W7034G JHSPH EHE, Baltimore, MD, 21205, USA.

Despite improvements in hospital infection prevention and control, healthcare associated infections (HAIs) remain a challenge with significant patient morbidity, mortality, and cost for the healthcare system. In this review, we use a One Health framework (human, animal, and environmental health) to explain the epidemiology, demonstrate key knowledge gaps in infection prevention policy, and explore improvements to control Gram-positive pathogens in the healthcare environment. We discuss patient and healthcare worker interactions with the hospital environment that can lead to transmission of the most common Gram-positive hospital pathogens - methicillin-resistant Staphylococcus aureus, Clostridioides (Clostridium) difficile, and vancomycin-resistant Enterococcus - and detail interventions that target these two One Health domains. Read More

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http://dx.doi.org/10.1186/s13756-020-00737-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268532PMC

ATP measurement as an objective method to measure environmental contamination in 9 hospitals in the Dutch/Belgian border area.

Antimicrob Resist Infect Control 2020 May 28;9(1):77. Epub 2020 May 28.

Department of Infection Control, Amphia Hospital, Breda, The Netherlands.

Background: The objective of this study was to determine the level of environmental contamination in hospitals in the Dutch/Belgian border area, using ATP measurements.

Design: A cross-sectional observational survey.

Methods: Standardized ATP measurements were conducted in 9 hospitals on 32 hospital wards. Read More

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http://dx.doi.org/10.1186/s13756-020-00730-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254657PMC

The effect of a 5-year hand hygiene initiative based on the WHO multimodal hand hygiene improvement strategy: an interrupted time-series study.

Antimicrob Resist Infect Control 2020 May 27;9(1):75. Epub 2020 May 27.

Department of Pediatrics, National Hospital Organization (NHO) Shimoshizu National Hospital, 934-5 Shikawatashi, Yotsukaido, 284-0003, Chiba, Japan.

Background: A World Health Organization (WHO) guideline-based multimodal hand hygiene (HH) initiative was introduced hospital-wide to a nonteaching Japanese hospital for 5 years. The objective of this study was to assess the effect of this initiative in terms of changes in alcohol-based hand rub (ABHR) consumption and the Hand Hygiene Self-Assessment Framework (HHSAF) score.

Methods: The consumption of monthly hospital-wide ABHR was calculated in L per 1000 patient days (PDs). Read More

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http://dx.doi.org/10.1186/s13756-020-00732-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251720PMC

Early discontinuation of empirical antibiotic treatment in neutropenic patients with acute myeloid leukaemia and high-risk myelodysplastic syndrome.

Antimicrob Resist Infect Control 2020 May 27;9(1):74. Epub 2020 May 27.

Department of Medical Microbiology and Infection Control, University Medical Centre Utrecht, Room G04.614, Heidelberglaan 100, Postbus 85500, 3508, GA, Utrecht, The Netherlands.

Introduction: Current guidelines advocate empirical antibiotic treatment (EAT) in haematological patients with febrile neutropenia. However, the optimal duration of EAT is unknown. In 2011, we have introduced a protocol, promoting discontinuation of carbapenems as EAT after 3 days in most patients and discouraging the standard use of vancomycin. Read More

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http://dx.doi.org/10.1186/s13756-020-00729-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251665PMC

Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections.

Antimicrob Resist Infect Control 2020 May 27;9(1):76. Epub 2020 May 27.

Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Background: Although Staphylococcus aureus bloodstream infections (SA-BSI) are a common and important infection, polymicrobial SA-BSI are infrequently reported. The aim of this study was to investigate the clinical characteristics and risk factors of polymicrobial SA-BSI in comparison with monomicrobial SA-BSI.

Methods: A single-center retrospective observational study was performed between Jan 1, 2013, and Dec 31, 2018 at a tertiary hospital. Read More

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http://dx.doi.org/10.1186/s13756-020-00741-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254655PMC

First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.

Antimicrob Resist Infect Control 2020 May 25;9(1):73. Epub 2020 May 25.

Department of Biomedical Sciences and Human Oncology, Hygiene Unit, University of Bari "Aldo Moro", P.zza G. Cesare 11, 70124, Bari, Italy.

Background: Pseudomonas aeruginosa (PA) is one of the most common and serious causes of healthcare-associated bacteremia. The emergence and dissemination of multidrug-resistant (MDR) and extensively drug-resistant (XDR) PA strains pose a major clinical concern. ST235-PA is a high-risk clone which shows a high capacity to acquire antibiotic resistance. Read More

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http://dx.doi.org/10.1186/s13756-020-00734-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249406PMC

Acquisition of multidrug-resistant Enterobacterales during international travel: a systematic review of clinical and microbiological characteristics and meta-analyses of risk factors.

Antimicrob Resist Infect Control 2020 May 20;9(1):71. Epub 2020 May 20.

Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

Background: International tourism increased from 25 million tourist arrivals in 1950 to over 1.3 billion in 2017. These travelers can be exposed to (multi) resistant microorganisms, may become colonized, and bring them back home. Read More

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http://dx.doi.org/10.1186/s13756-020-00733-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237615PMC

A national survey of public awareness of antimicrobial resistance in Nigeria.

Antimicrob Resist Infect Control 2020 May 20;9(1):72. Epub 2020 May 20.

Center for Human Virology and Genomics, Microbiology Department, Nigerian Institute of Medical Research, Yaba, Lagos State, Nigeria.

Background: One of the objectives of the Global Action Plan by the World Health Organization (WHO) to contain antimicrobial resistance (AMR), is to improve global awareness through effective communication and education. Comprehensive information on the level of awareness of AMR among Nigerian public is deficient. This study was therefore designed to assess the current level of awareness and knowledge of the Nigerian public of AMR. Read More

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http://dx.doi.org/10.1186/s13756-020-00739-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238560PMC

Emergence of β-lactamase- and carbapenemase- producing Enterobacteriaceae at integrated fish farms.

Antimicrob Resist Infect Control 2020 May 19;9(1):67. Epub 2020 May 19.

Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, Giza square, PO Box 12211, Cairo, Egypt.

Background: Epidemiological studies suggested that determinants for antibiotic resistance have originated in aquaculture. Recently, the integrated agriculture-aquaculture system has been implemented, where fish are raised in ponds that receive agriculture drainage water. The present study aims to investigate the occurrence of β-lactamase and carbapenemase-producing Enterobacteriaceae in the integrated agriculture-aquaculture and the consequent public health implication. Read More

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http://dx.doi.org/10.1186/s13756-020-00736-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236517PMC

Rumors and incorrect reports are more deadly than the new coronavirus (SARS-CoV-2).

Antimicrob Resist Infect Control 2020 05 19;9(1):68. Epub 2020 May 19.

Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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http://dx.doi.org/10.1186/s13756-020-00738-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235536PMC

In vitro evaluation of double carbapenem and colistin combinations against OXA-48, NDM carbapenemase-producing colistin-resistant Klebsiella pneumoniae strains.

Antimicrob Resist Infect Control 2020 May 19;9(1):70. Epub 2020 May 19.

Department of Infection Disease and Clinical Microbiology, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey.

Background: Treatment of pandrug-resistant isolates often necessitates combination therapy. Checkerboard synergy and time-killing assay tests were performed to evaluate the benefits of a triple combination with meropenem, ertapenem, and colistin against 10 colistin-resistant K. pneumoniae clinical isolates harboring different β-lactamases. Read More

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http://dx.doi.org/10.1186/s13756-020-00727-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238654PMC

Predicting the occurrence of multidrug-resistant organism colonization or infection in ICU patients: development and validation of a novel multivariate prediction model.

Antimicrob Resist Infect Control 2020 May 19;9(1):66. Epub 2020 May 19.

Intensive Care Unit, First Affiliated Hospital of Xiamen University, 55 Zhen Hai Road, Xiamen, 361000, Fujian Province, China.

Background: Multidrug-resistant organisms (MDROs) have emerged as an important cause of poor prognoses of patients in the intensive care unit (ICU). This study aimed to establish an easy-to-use nomogram for predicting the occurrence of MDRO colonization or infection in ICU patients.

Methods: In this study, we developed a nomogram based on predictors in patients admitted to the ICU in the First Affiliated Hospital of Xiamen University from 2016 to 2018 using univariate and multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1186/s13756-020-00726-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236142PMC

Implementing a combined infection prevention and control with antimicrobial stewardship joint program to prevent caesarean section surgical site infections and antimicrobial resistance: a Tanzanian tertiary hospital experience.

Antimicrob Resist Infect Control 2020 May 19;9(1):69. Epub 2020 May 19.

"Lazzaro Spallanzani" National Institute for Infectious Diseases-IRCCS, Via Portuense 292, Rome, Italy.

Background: Surgical site infections are a leading cause of morbidity and mortality after caesarean section, especially in Low and Middle Income Countries. We hypothesized that a combined infection prevention and control with antimicrobial stewardship joint program would decrease the rate of post- caesarean section surgical site infections at the Obstetrics & Gynaecology Department of a Tanzanian tertiary hospital.

Methods: The intervention included: 1. Read More

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http://dx.doi.org/10.1186/s13756-020-00740-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236265PMC

Implementation of the WHO hand hygiene strategy in Faranah regional hospital, Guinea.

Antimicrob Resist Infect Control 2020 May 14;9(1):65. Epub 2020 May 14.

Centre for International Health Protection, Robert Koch Institute, Berlin, Germany.

Background: Healthcare-associated infections are the most frequent adverse events in healthcare worldwide, with limited available evidence suggesting highest burden in resource-limited settings. Recent Ebola epidemics emphasize the disastrous impact that spread of infectious agents within healthcare facilities can have, accentuating the need for improvement of infection control practices. Hand hygiene (HH) measures are considered to be the most effective tool to prevent healthcare-associated infections. Read More

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http://dx.doi.org/10.1186/s13756-020-00723-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227248PMC

Outbreak investigation of Serratia marcescens neurosurgical site infections associated with a contaminated shaving razors.

Antimicrob Resist Infect Control 2020 May 12;9(1):64. Epub 2020 May 12.

Center for Infection Control and Prevention, Seoul National University Hospital, Seoul, South Korea.

Background: Surgical site infection (SSI) is the most common healthcare-associated infection. We report an outbreak of neurosurgical site infections caused by Serratia marcescens after craniotomy in a tertiary care hospital.

Methods: Between August 6 and 21, 2018, five cases of early-onset SSI caused by S. Read More

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http://dx.doi.org/10.1186/s13756-020-00725-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216399PMC

Clinical impact of endemic NDM-producing Klebsiella pneumoniae in intensive care units of the national referral hospital in Jakarta, Indonesia.

Antimicrob Resist Infect Control 2020 May 11;9(1):61. Epub 2020 May 11.

Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.

Objective: A prospective observational study was performed to assess the epidemiology and clinical impact of carbapenem-non-susceptible Klebsiella pneumoniae (CNKP) in intensive care units (ICUs) of the national referral hospital in Jakarta, Indonesia.

Materials/methods: Adult patients consecutively hospitalized for > 48 h in two ICUs of the national referral hospital were included from April until October 2013 and from April until August 2014. K. Read More

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http://dx.doi.org/10.1186/s13756-020-00716-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216366PMC

Point-prevalence survey of hospital acquired infections in three acute care hospitals in Northern Nigeria.

Authors:
Usman Abubakar

Antimicrob Resist Infect Control 2020 May 11;9(1):63. Epub 2020 May 11.

Pharmacy Department, Ibrahim Badamasi Babangida (IBB) Specialist Hospital, Minna, Niger State, Nigeria.

Background: Effective infection prevention and control strategies require reliable data describing the epidemiology of hospital acquired infections (HAIs), and this is currently lacking in Nigeria. The objective of this study was to evaluate the prevalence, types and risk factors associated with HAIs in acute care hospitals in Northern Nigeria.

Methods: A pilot point-prevalence survey was conducted in three acute care hospitals in Northern Nigeria between April and May 2019 using a protocol developed by the European Centre for Disease Prevention and Control. Read More

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http://dx.doi.org/10.1186/s13756-020-00722-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216694PMC

Screening for triazole resistance in clinically significant Aspergillus species; report from Pakistan.

Antimicrob Resist Infect Control 2020 May 11;9(1):62. Epub 2020 May 11.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

Background: Burden of aspergillosis is reported to be significant from developing countries including those in South Asia. The estimated burden in Pakistan is also high on the background of tuberculosis and chronic lung diseases. There is concern for management of aspergillosis with the emergence of azole resistant Aspergillus species in neighbouring countries in Central and South Asia. Read More

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http://dx.doi.org/10.1186/s13756-020-00731-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216335PMC

The potential negative impact of antibiotic pack on antibiotic stewardship in primary care in Switzerland: a modelling study.

Antimicrob Resist Infect Control 2020 May 8;9(1):60. Epub 2020 May 8.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Background: In Switzerland, oral antibiotics are dispensed in packs rather than by exact pill-count. We investigated whether available packs support compliance with recommended primary care treatment regimens for common infections in children and adults.

Methods: Hospital-based guidelines for oral community -based treatment of acute otitis media, sinusitis, tonsillopharyngitis, community-acquired pneumonia and afebrile urinary tract infection were identified in 2017 in an iterative process by contacting hospital pharmacists and infectious diseases specialists. Read More

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http://dx.doi.org/10.1186/s13756-020-00724-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206713PMC

Correction to: Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review.

Antimicrob Resist Infect Control 2020 May 7;9(1):59. Epub 2020 May 7.

Pediatric Infectious Disease Research Group, Institute for Infection and Immunity, St George's University of London, London, UK.

The original article [1] contains an error in Fig. 1 whereby the number of selected articles of the first box is incorrect. Read More

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http://dx.doi.org/10.1186/s13756-020-00720-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206826PMC

Bacteremia in critical care units at Bugando Medical Centre, Mwanza, Tanzania: the role of colonization and contaminated cots and mothers' hands in cross-transmission of multidrug resistant Gram-negative bacteria.

Antimicrob Resist Infect Control 2020 May 6;9(1):58. Epub 2020 May 6.

Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P. O. Box 1464, Bugando, Mwanza, Tanzania.

Background: Multidrug resistance (MDR) is a major clinical problem in tertiary hospitals in Tanzania and jeopardizes the life of neonates in critical care units (CCUs). To better understand methods for prevention of MDR infections, this study aimed to determine, among other factors, the role of MDR-Gram-negative bacteria (GNB) contaminating neonatal cots and hands of mothers as possible role in transmission of bacteremia at Bugando Medical Centre (BMC), Mwanza, Tanzania.

Methods: This cross-sectional, hospital-based study was conducted among neonates and their mothers in a neonatal intensive care unit and a neonatology unit at BMC from December 2018 to April 2019. Read More

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http://dx.doi.org/10.1186/s13756-020-00721-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201549PMC

The great nursing brain drain and its effects on patient safety.

Antimicrob Resist Infect Control 2020 Apr 30;9(1):57. Epub 2020 Apr 30.

Infection Control Programme, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

The World Health Organization (WHO) has declared 2020 the "Year of the Nurse and Midwife". On May 5th of this year, for the annual celebration of the SAVE LIVES: Clean Your Hands campaign, the WHO will focus on the critical role of nurses and midwives in promoting public health. The brain drain of healthcare workers (HCWs) leads to unequal distribution of nurses and midwives around the world, which affects the quality of care provided to patients. Read More

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http://dx.doi.org/10.1186/s13756-020-00719-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193335PMC

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase-negative staphylococci strains: a systematic review and meta-analysis.

Antimicrob Resist Infect Control 2020 Apr 22;9(1):56. Epub 2020 Apr 22.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Objective: Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCoNS) are among the main causes of nosocomial infections, which have caused major problems in recent years due to continuously increasing spread of various antibiotic resistance features. Apparently, vancomycin is still an effective antibiotic for treatment of infections caused by these bacteria but in recent years, additional resistance phenotypes have led to the accelerated introduction of newer agents such as linezolid, tigecycline, daptomycin, and quinupristin/dalfopristin (Q/D). Due to limited data availability on the global rate of resistance to these antibiotics, in the present study, the resistance rates of S. Read More

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http://dx.doi.org/10.1186/s13756-020-00714-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178749PMC

Persuasive antimicrobial stewardship intervention in the context of a KPC outbreak: a controlled interrupted time series analysis.

Antimicrob Resist Infect Control 2020 Apr 21;9(1):55. Epub 2020 Apr 21.

EPIUnit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.

Introduction: Antimicrobial resistance is a major public health threat. Antimicrobial stewardship (AMS) is one of the key strategies to overcome resistance, but robust evidence on the effect of specific interventions is lacking. We report an interrupted time series (ITS) analysis of a persuasive AMS intervention implemented during a KPC producing Klebsiella pneumoniae outbreak. Read More

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http://dx.doi.org/10.1186/s13756-020-00718-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175563PMC

"Nurses and midwives: clean care is in your hands": the 5th May 2020 World Health Organization SAVE LIVES: Clean Your Hands campaign.

Antimicrob Resist Infect Control 2020 Apr 19;9(1):54. Epub 2020 Apr 19.

Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

In honor of Florence Nightingale's 200th birthday, the World Health Organization (WHO) has declared 2020 the "Year of the Nurse and Midwife". On May 5th of this year, for the annual celebration of the SAVE LIVES: Clean Your Hands campaign, WHO will focus on the essential role that nurses and midwives play in contributing to saving millions of lives per year. It is necessary to recognize the work and the immense responsibility that nurses and midwives carry since achieving Universal Health Coverage is highly reliant on them. Read More

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http://dx.doi.org/10.1186/s13756-020-00717-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168943PMC