570 results match your criteria Antimicrobial Resistance And Infection Control[Journal]


Doxycycline-encapsulated solid lipid nanoparticles as promising tool against enclosed in macrophage: a pharmacodynamics study on J774A.1 cell line.

Antimicrob Resist Infect Control 2019 3;8:62. Epub 2019 Apr 3.

1Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid fahmideh street, Park Mardome, Hamadan, IR Iran.

Background: Brucellosis is a zoonotic disease caused by species. It has been estimated that more than 500,000 new cases of Brucellosis occur annually all around the world. Relapse of the disease is one of the most important challenges. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
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http://dx.doi.org/10.1186/s13756-019-0504-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448226PMC
April 2019
1 Read

Shifting trends and age distribution of ESKAPEEc resistance in bloodstream infection, Southwest China, 2012-2017.

Antimicrob Resist Infect Control 2019 29;8:61. Epub 2019 Mar 29.

1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Yuzhong District, Chongqing, 400016 People's Republic of China.

Background: ESKAPEEc contribute to a majority of bloodstream infections (BSIs) and their antibiogram have changed overtime, while data concerning about these alterations are lacking in China. Added that a paucity of studies referred to ESKAPEEc in pediatric BSIs, our study aimed to demonstrate the longitudinal alterations of ESKAPEEc distribution and antibiogram in adult and pediatric BSIs in Southwest China.

Methods: A multicenter retrospective surveillance study was launched from 2012 to 2017. Read More

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http://dx.doi.org/10.1186/s13756-019-0499-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441235PMC
March 2019
1 Read

Community pharmacy staff's response to symptoms of common infections: a pseudo-patient study.

Antimicrob Resist Infect Control 2019 29;8:60. Epub 2019 Mar 29.

1The University of Sydney School of Pharmacy, Sydney, NSW Australia.

Background: Inappropriate over-the-counter supply of antibiotics in pharmacies for common infections is recognised as a source of antibiotic misuse that can worsen the global burden of antibiotic resistance.

Objectives: To assess responses of community pharmacy staff to pseudo-patients presenting with symptoms of common infections and factors associated with such behaviour.

Methods: A cross-sectional pseudo-patient study was conducted from Jan-Sept 2017 among 242 community pharmacies in Sri Lanka. Read More

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http://dx.doi.org/10.1186/s13756-019-0510-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439995PMC

Molecular characterization of class 1, 2 and 3 integrons in clinical multi-drug resistant isolates.

Antimicrob Resist Infect Control 2019 29;8:59. Epub 2019 Mar 29.

3Evidence-based Phytotherapy & Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Background: The aim of this study was to characterize class 1,2 and 3 integrons in clinical MDR isolates in Kashan, Iran.

Methods: One hundred-eighty one were recovered from clinical specimens during November 2013 to October 2014. Antimicrobial susceptibility patterns were determined by disk diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for detection of MDR strains. Read More

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http://dx.doi.org/10.1186/s13756-019-0509-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440154PMC

Scenario-based simulation training for the WHO hand hygiene self-assessment framework.

Antimicrob Resist Infect Control 2019 28;8:58. Epub 2019 Mar 28.

Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, 4 Rue Gabrielle-Perret-Gentil, 1211 Geneva 14, Switzerland.

The WHO global hand hygiene campaign, launched in 2009 and celebrated annually on the 5th of May, features specific calls to action seeking to increase engagement from stakeholders' collaborations in hand hygiene improvement. WHO calls on everyone to be inspired by the global movement towards universal health coverage (UHC). Infection prevention and control (IPC), including hand hygiene, is critical to achieve UHC as it has a direct impact on quality of care and patient safety across all levels of the health services. Read More

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http://dx.doi.org/10.1186/s13756-019-0511-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437984PMC

Successful implementation of infection control measure in a neonatal intensive care unit to combat the spread of pathogenic multidrug resistant .

Antimicrob Resist Infect Control 2019 27;8:57. Epub 2019 Mar 27.

5International Center of Research in Infectiology, INSERM U1111, CNRS UMR5308, Ecole Normale Supérieure, Lyon, France.

Background: Once present in a neonatal intensive care unit (NICU), multidrug resistant NRCS-A is able to settle and diffuse.

Objective: The objective of this study was to evaluate the impact of infection control (IC) interventions to reduce the spread of NRCS-A in a NICU.

Methods: Between December 2012 and December 2017, all patients presenting positive sampling (blood, skin or catheter) to were included, and clinical data were recorded from electronic clinical charts. Read More

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http://dx.doi.org/10.1186/s13756-019-0512-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437968PMC
March 2019
1 Read

Impact of psychologically tailored hand hygiene interventions on nosocomial infections with multidrug-resistant organisms: results of the cluster-randomized controlled trial PSYGIENE.

Antimicrob Resist Infect Control 2019 25;8:56. Epub 2019 Mar 25.

2Hannover Medical School, Centre for Laboratory Medicine, Institute of Medical Microbiology and Hospital Epidemiology, Carl-Neuberg-Str. 1, OE 5214, 30625 Hannover, Germany.

Background: Professional hand hygiene compliance represents a multifaceted behaviour with various determinants. Thus, it has been proposed to apply psychological frameworks of behaviour change to its promotion. However, randomized controlled trials of such approaches, which also assess nosocomial infections (NIs), are rare. Read More

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http://dx.doi.org/10.1186/s13756-019-0507-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434638PMC
March 2019
1 Read

Genomic analysis of multidrug-resistant clinical isolates for antimicrobial resistance genes and virulence factors from the western region of Saudi Arabia.

Antimicrob Resist Infect Control 2019 25;8:55. Epub 2019 Mar 25.

1Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589 Saudi Arabia.

Background: is a ubiquitous member of the gut microbiota and has emerged as a life- threatening multidrug-resistant (MDR) nosocomial pathogen. The aim of this study was to survey the prevalence of multidrug-resistant and epidemiologically important strains of in the western region of Saudi Arabia using phenotypic and whole genome sequencing approaches.

Methods: In total, 155 patients positive for infection were included in this study. Read More

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http://dx.doi.org/10.1186/s13756-019-0508-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434864PMC
March 2019
1 Read

Phenotypic and genotypic characterization of antibiotic resistance in the methicillin-resistant strains isolated from hospital cockroaches.

Antimicrob Resist Infect Control 2019 13;8:54. Epub 2019 Mar 13.

Halal Research Center of IRI, FDA, Tehran, Iran.

Background: Cockroaches are one of the most important and frequent insects responsible for harboring, transmission and dissemination of human pathogens in the hospital environment. The present research was done to study the phenotypic and genotypic characterization of antibiotic resistance in the Methicillin-resistant strains isolated from hospital cockroaches.

Methods: Five-hundred and thirty and cockroaches were collected and their gut content and external washing samples were subjected to bacterial isolation. Read More

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http://dx.doi.org/10.1186/s13756-019-0505-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416839PMC

The value of the infection prevention and control nurse led MRSA ward round.

Antimicrob Resist Infect Control 2019 12;8:53. Epub 2019 Mar 12.

1University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, B15 2WB UK.

Meticillin-resistant (MRSA) is prevalent in most parts of the world. The study took place at Queen Elizabeth Hospital Birmingham (QEHB) a UK tertiary referral hospital. At QEHB innovative nurse led daily ward rounds for patients that acquire hospital acquired MRSA during their hospital stay are undertaken. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
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http://dx.doi.org/10.1186/s13756-019-0506-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417022PMC
March 2019
6 Reads

Prevalence of plasmid-mediated AmpC in Enterobacteriaceae isolated from humans and from retail meat in Zagazig, Egypt.

Antimicrob Resist Infect Control 2019 26;8:45. Epub 2019 Feb 26.

1Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Immunity and Infection Institute, Amsterdam, The Netherlands.

Background: The objective of this study was to determine the prevalence of plasmid-mediated AmpC (pAmpC) among Enterobacteriaceae isolated from humans and from retail meat in Egypt.

Methods: Enterobacteriaceae were isolated from patients with suspected bloodstream infection, human fecal samples, retail chicken meat samples and retail sheep meat samples. All group I Enterobacteriaceae were analyzed for presence of pAmpC genes by PCR. Read More

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http://dx.doi.org/10.1186/s13756-019-0494-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390348PMC
February 2019
1 Read

Comparison of Tigecycline or Cefoperazone/Sulbactam therapy for bloodstream infection due to Carbapenem-resistant .

Antimicrob Resist Infect Control 2019 6;8:52. Epub 2019 Mar 6.

1Collaborative Initiative Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, college of Medicine, Zhejiang University, Hangzhou, 310003 China.

Background: We retrospectively analyzed the effect of tigecycline and cefoperazone/sulbactam therapies on the prognosis of patients with carbapenem-resistant bloodstream infection (CRAB-BSI).

Methods: CRAB-BSI patients receiving tigecycline therapy or cefoperazone/sulbactam therapy between January 2012 and December 2017 was enrolled, and strict exclusion criteria were followed. The 28-day mortality of patients was analyzed. Read More

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http://dx.doi.org/10.1186/s13756-019-0502-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404342PMC

Evaluating the impact of the ICNET® clinical decision support system for antimicrobial stewardship.

Antimicrob Resist Infect Control 2019 6;8:51. Epub 2019 Mar 6.

1Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH UK.

Background: Antimicrobial resistance (AMR) is an ecological and economic crisis and stewardship of available antimicrobials is required. Electronic prescribing, where available, enables auditing of practice, yet in order to be efficient and effective in addressing inappropriate antimicrobial prescribing, better use of current and new technological interventions is needed. This retrospective observational evaluation looked at the impact of a commercial clinical decision support system (CDSS) on the workflow of an established antimicrobial stewardship (AMS) team. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
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http://dx.doi.org/10.1186/s13756-019-0496-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404285PMC
March 2019
6 Reads

High prevalence of direct repeat unit types of 10di, 8 h and 8i among methicillin resistant strains with staphylococcal cassette chromosome type IIIA isolated in Tehran, Iran.

Antimicrob Resist Infect Control 2019 6;8:50. Epub 2019 Mar 6.

3Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Building No. 7, 100 Poursina St., Keshavarz Blvd., Tehran, 14167-53955 Iran.

Background: The emergence of methicillin-resistant (MRSA) is a main concern in burn care centers worldwide. The some reports of MRSA in Iran suggested that MRSA with type SCC III is common among burn patients. The aim of this study was to determine the prevalence, virulence genes, and antimicrobial susceptibility of the direct repeat units () types of MRSA with SCC IIIA isolated from burn wounds in a burn care center in Tehran, Iran. Read More

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http://dx.doi.org/10.1186/s13756-019-0501-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404295PMC

Facility type and surgical specialty are associated with suboptimal surgical antimicrobial prophylaxis practice patterns: a multi-center, retrospective cohort study.

Antimicrob Resist Infect Control 2019 6;8:49. Epub 2019 Mar 6.

2Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston, Healthcare System, 150 South Huntington Avenue, Boston, MA 02130 USA.

Background: Guidelines recommend discontinuation of antimicrobial prophylaxis within 24 h after incision closure in uninfected patients. However, how facility and surgical specialty factors affect the implementation of these evidence-based surgical prophylaxis guidelines in outpatient surgery is unknown. Thus, we sought to measure how facility complexity, including ambulatory surgical center (ASC) status and availability of ancillary services, impact adherence to guidelines for timely discontinuation of antimicrobial prophylaxis after outpatient surgery. Read More

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http://dx.doi.org/10.1186/s13756-019-0503-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404270PMC

Epidemiological, clinical, and microbiological characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection in the Republic of Korea.

Antimicrob Resist Infect Control 2019 5;8:48. Epub 2019 Mar 5.

Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Yongsan-gu, Seoul, 04401 Republic of Korea.

Background: Carbapenemase-producing Enterobacteriaceae (CPE) is an important pathogen in nosocomial infections; nevertheless, only a few studies regarding CPE infection and its epidemiological factors have been conducted in the Republic of Korea (ROK). We aimed to analyze the clinical, microbiological, and epidemiological characteristics of CPE bloodstream infections (BSIs) in the ROK.

Methods: This retrospective cohort study included data collected from the National Surveillance System from January 2015 to December 2016 based on the epidemiologic survey performed by an epidemiologist from the Korea Centers for Disease Control and Prevention. Read More

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https://aricjournal.biomedcentral.com/articles/10.1186/s1375
Publisher Site
http://dx.doi.org/10.1186/s13756-019-0497-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402157PMC
March 2019
2 Reads

The public washroom - friend or foe? An observational study of washroom cleanliness combined with microbiological investigation of hand hygiene facilities.

Antimicrob Resist Infect Control 2019 28;8:47. Epub 2019 Feb 28.

1School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, SAR China.

Background: Many people use handwashing and hand-drying facilities in public washrooms under the impression that these amenities are hygienic. However, such facilities may be potential sites for the transmission of pathogenic bacteria. This study aimed to examine the hygiene facilities provided including handwashing and hand-drying facilities in public washrooms. Read More

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http://dx.doi.org/10.1186/s13756-019-0500-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396476PMC
February 2019
1 Read

Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and gene in causing neonatal septicaemia.

Antimicrob Resist Infect Control 2019 27;8:46. Epub 2019 Feb 27.

1Division of Bacteriology, ICMR-National Institute of Cholera and Enteric Diseases, P33, CIT Road, Scheme XM, Beliaghata, Kolkata, 700010 India.

Background: The (New Delhi Metallo-β-lactamase-1) gene has disseminated around the globe. NDM-1 producers are found to co-harbour resistance genes against many antimicrobials, including fluoroquinolones. The spread of large plasmids, carrying both and plasmid-mediated fluoroquinolone resistance (PMQR) markers, is one of the main reasons for the failure of these essential antimicrobials. Read More

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http://dx.doi.org/10.1186/s13756-019-0477-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391786PMC
February 2019
2 Reads

The nature and epidemiology of OqxAB, a multidrug efflux pump.

Antimicrob Resist Infect Control 2019 22;8:44. Epub 2019 Feb 22.

1National Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug Residues, Wuhan, 430070 Hubei China.

Background: OqxAB efflux pump has been found to mediate multidrug resistance (MDR) in various bacteria over the past decades. The updates on the nature and epidemiology of OqxAB efflux pump need to be fully reviewed to broaden our understanding of this MDR determinant.

Methods: A literature search using the keyword of "oqxAB" was conducted in the online databases of Pubmed and ISI Web of Science with no restriction on the date of publication. Read More

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http://dx.doi.org/10.1186/s13756-019-0489-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387526PMC
February 2019

Obstacles to the successful introduction of an electronic hand hygiene monitoring system, a cohort observational study.

Antimicrob Resist Infect Control 2019 22;8:43. Epub 2019 Feb 22.

1Unit for infection Prevention and Control, Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, POB 12000, 9112001 Jerusalem, Israel.

Background: Hand hygiene (HH) compliance remains low in many intensive care units (ICU). Technology has been suggested to improve HH compliance.We describe the introduction of an electronic HH surveillance and intervention system into the general ICU of a tertiary care teaching hospital, the obstacles to success and reasons for the system's ultimate failure and removal. Read More

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http://dx.doi.org/10.1186/s13756-019-0498-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387532PMC
February 2019

Blood culture result profile and antimicrobial resistance pattern: a report from neonatal intensive care unit (NICU), Asella teaching and referral hospital, Asella, south East Ethiopia.

Antimicrob Resist Infect Control 2019 20;8:42. Epub 2019 Feb 20.

Arsi University Asella College of Health Science, Asella, Ethiopia.

Background: Antimicrobial resistance is one of the major public health emergencies worldwide, and this trend didn't spare developing countries like Ethiopia. The objective of this study was to evaluate patterns of bacterial isolates and local antimicrobial susceptibility patterns in neonatal sepsis.

Methods: A hospital based observational study was conducted from April 2016 to May 2017 in Asella teaching and referral hospital (ATRH). Read More

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http://dx.doi.org/10.1186/s13756-019-0486-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383240PMC
February 2019
3 Reads

A compilation of antimicrobial susceptibility data from a network of 13 Lebanese hospitals reflecting the national situation during 2015-2016.

Antimicrob Resist Infect Control 2019 20;8:41. Epub 2019 Feb 20.

7Department of Internal Medicine, Division of Infectious Diseases, Lebanese American University-Rizk Hospital, Beirut, Lebanon.

Background: There is a lack of official national antimicrobial resistance (AMR) data in Lebanon. Individual hospitals generate their own antibiotic susceptibility data in the form of yearly pamphlets.

Methods: In this study, antibiotic susceptibility data from 13 hospitals distributed across different governorates of Lebanon were collected to conduct a compilation-based surveillance of AMR in Lebanon for the years 2015-2016. Read More

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http://dx.doi.org/10.1186/s13756-019-0487-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381724PMC
February 2019
4 Reads

Effective therapeutic regimens in two South Asian countries with high resistance to major antibiotics.

Antimicrob Resist Infect Control 2019 15;8:40. Epub 2019 Feb 15.

1Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60131 Indonesia.

Background: Nepal and Bangladesh have a high prevalence of with high resistance rates to clarithromycin, metronidazole, and levofloxacin. Here, we evaluated the susceptibility and genetic mutations of 5 alternative antibiotics against isolates from both countries to obtain an effective treatment regimen for eradication.

Methods: We used the agar dilution method to determine the minimal inhibitory concentration of 5 alternative antibiotics against 42 strains from Nepal and 56 from Bangladesh and performed whole genome mutation analysis. Read More

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http://dx.doi.org/10.1186/s13756-019-0482-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377755PMC
February 2019
3 Reads

Extended-spectrum beta-lactamase production and multi-drug resistance among isolated in Addis Ababa, Ethiopia.

Antimicrob Resist Infect Control 2019 15;8:39. Epub 2019 Feb 15.

2Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: The global emergence and spread of extended-spectrum beta-lactamases (ESBLs) producing have been threatening the ability to treat an infection. Hence, this study aimed to determine the prevalence of ESBL-producing and multi-drug resistance (MDR) (ESBLs-E) from different clinical specimens in Addis Ababa, Ethiopia.

Methods: A cross-sectional study was conducted from January 1 to May 30, 2017. Read More

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http://dx.doi.org/10.1186/s13756-019-0488-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377715PMC
February 2019

Influence of antibiotic pressure on multi-drug resistant colonisation in critically ill patients.

Antimicrob Resist Infect Control 2019 14;8:38. Epub 2019 Feb 14.

3Intensive Care Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Background: The aim of this study is to evaluate the risk factors for colonisation by multidrug resistant (MDR) in a critical care unit and the relationship between colonisation and the antibiotic pressure exerted by the antimicrobial treatments received by patients.

Methods: A prospective observational was designed. Patients admitted for more than 48 h to an intensive care unit were included. Read More

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http://dx.doi.org/10.1186/s13756-019-0484-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375121PMC
February 2019

Nation-wide survey of screening practices to detect carriers of multi-drug resistant organisms upon admission to Swiss healthcare institutions.

Antimicrob Resist Infect Control 2019 13;8:37. Epub 2019 Feb 13.

1Infection Control Programme and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

As emergence and spread of multi-drug resistant organisms (MDRO) requires a standardized preventive approach, we aimed to evaluate current MDRO admission screening practices in Swiss hospitals and to identify potential barriers impeding their implementation. In early 2018, all Swiss public and private healthcare institutions providing inpatient care were contacted with a 34-item questionnaire to investigate current MDRO admission screening policies. Among 139 respondents representing 180 institutions (response rate, 79%), 83% (149) of institutions implemented MDRO admission screening, while 28% of private and 9% of public institutions did not perform any screening. Read More

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http://dx.doi.org/10.1186/s13756-019-0479-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375162PMC
February 2019
1 Read

Individual and community predictors of urinary ceftriaxone-resistant isolates, Victoria, Australia.

Antimicrob Resist Infect Control 2019 12;8:36. Epub 2019 Feb 12.

3Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria Australia.

Background: Ceftriaxone-resistant Enterobacteriaceae are priority pathogens of critical importance. is the most commonly isolated Enterobacteriaceae. There are few data regarding non-invasive ceftriaxone-resistant (CR-EC) isolates in the Australian community. Read More

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http://dx.doi.org/10.1186/s13756-019-0492-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373108PMC
February 2019

Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review.

Antimicrob Resist Infect Control 2019 12;8:35. Epub 2019 Feb 12.

4Pfizer, Paris, France.

Background: Hospital antimicrobial stewardship programs (ASPs) aim to promote judicious use of antimicrobials to combat antimicrobial resistance. For ASPs to be developed, adopted, and implemented, an economic value assessment is essential. Few studies demonstrate the cost-effectiveness of ASPs. Read More

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http://dx.doi.org/10.1186/s13756-019-0471-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373132PMC
February 2019

Implementation of antibiotic stewardship in different settings - results of an international survey.

Antimicrob Resist Infect Control 2019 12;8:34. Epub 2019 Feb 12.

3University of Dundee, Medical School, Dundee, Scotland.

Background: Antibiotic stewardship interventions are being implemented across different healthcare settings. We report the findings of a global survey of healthcare professionals on the implementation of antibiotic stewardship programmes.

Methods: Learners of a Massive Online Open Course (MOOC) on antibiotic stewardship were invited to complete an online survey on the core available organisational resources for stewardship. Read More

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http://dx.doi.org/10.1186/s13756-019-0493-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373024PMC
February 2019

Incidence of community onset MRSA in Australia: least reported where it is Most prevalent.

Antimicrob Resist Infect Control 2019 12;8:33. Epub 2019 Feb 12.

1Australian Centre for Health Services Innovation and the Institute for Health and Biomedical Innovation, Queensland University Technology, Brisbane, Australia.

Background: This is the first review of literature and synthesis of data on community onset methicillin resistant (CO-MRSA) infections in Australia. Incidence of CO-MRSA varies considerably in Australia, depending on geographic and demographic factors.

Methods: Data for the rates of MRSA infections were collected from articles identified using PubMed, Scopus, the grey literature and data from State and Federal Government Surveillance Systems. Read More

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http://dx.doi.org/10.1186/s13756-019-0485-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373119PMC
February 2019

Implementation of infection prevention and control in acute care hospitals in Mainland China - a systematic review.

Antimicrob Resist Infect Control 2019 11;8:32. Epub 2019 Feb 11.

Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14, Switzerland.

Background: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) affect patients in acute-care hospitals worldwide. No systematic review has been published on adoption and implementation of the infection prevention and control (IPC) key components. The objective of this systematic review was to assess adoption and implementation of the three areas issued by the "National Health Commission of the People's Republic of China" in acute-care hospitals in Mainland China, and to compare the findings with the key and core components on effective IPC, issued by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1186/s13756-019-0481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371478PMC
February 2019
1 Read

Phenotypic and molecular characterisations of carbapenem-resistant strains isolated in Madagascar.

Antimicrob Resist Infect Control 2019 11;8:31. Epub 2019 Feb 11.

1Institut Pasteur de Madagascar, Antananarivo, Madagascar.

Background: The present study aimed to perform a deep phenotypic and genotypic analysis of 15 clinical carbapenem-resistant (CRAb) strains isolated in Madagascar between 2008 and 2016 from diverse sources.

Methods: CRAb isolates collected from the Clinical Biology Centre of the Institut Pasteur of Madagascar, from the neonatal unit of Antananarivo military hospital, and from intensive care units of Mahajanga Androva and Antananarivo Joseph Ravoahangy Andrianavalona (HJRA) hospitals were subjected to susceptibility testing. Whole-genome sequencing allowed us to assess the presence of antibiotic-resistance determinants, insertion sequences, integrons, genomic islands and potential virulence factors in all strains. Read More

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http://dx.doi.org/10.1186/s13756-019-0491-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371490PMC
February 2019

Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections.

Antimicrob Resist Infect Control 2019 11;8:30. Epub 2019 Feb 11.

1Department of Pharmacy, University of Split School of Medicine, Soltanska 2, Split, Croatia.

Background: The aim of this study was to investigate whether marketed antibiotics package sizes are in accordance with treatment durations recommended in guidelines for prescribing antibiotics in sore throat and urinary tract infections.

Methods: National drug database was searched with limitation to Antibacterials for systemic use. Formulations which did not have pre-specified dosage unit by the manufacturer were excluded (e. Read More

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http://dx.doi.org/10.1186/s13756-019-0495-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371554PMC
February 2019

Neonatal sepsis due to glycopeptide resistant from colonized maternal gut- rare case evidence.

Antimicrob Resist Infect Control 2019 8;8:29. Epub 2019 Feb 8.

1Department of Medical Microbiology, Manipal College of Medical Sciences, Pokhara, Nepal.

Background: Vancomycin-resistant enterococcal infections in the neonatal ICU are growing global problems. We report a case of neonatal septicemia by multidrug-resistant vancomycin-resistant (VRE), the source of infection being the mother's gut.

Case Presentation: A newborn male child admitted to the neonatal intensive care unit (NICU) was diagnosed to have mild meconium aspiration syndrome, early onset neonatal septicemia, and bacteremia by multidrug and vancomycin-resistant . Read More

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http://dx.doi.org/10.1186/s13756-019-0490-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368750PMC
February 2019

Use of microbiology tests in the era of increasing AMR rates- a multicentre hospital cohort study.

Antimicrob Resist Infect Control 2019 4;8:28. Epub 2019 Feb 4.

10Department of Essential Medicines and Health Products, World Health Organization (WHO), Avenue Appia 20, 1211 Geneva 27, Switzerland.

Background: Effective use of microbiology test results may positively influence patient outcomes and limit the use of broad-spectrum antibiotics. However, studies indicate that their potential is not fully utilized. We investigated microbiology test ordering practices and the use of test results for antibiotic decision-making in hospitals. Read More

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http://dx.doi.org/10.1186/s13756-019-0480-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360791PMC
February 2019
7 Reads

Relationship between tetracycline antibiotic susceptibility and genotype in oral cavity clinical isolates.

Antimicrob Resist Infect Control 2019 4;8:27. Epub 2019 Feb 4.

Central Laboratory, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, People's Republic of China.

Background: Antibiotic resistance, is often conferred by the presence of antibiotic resistance genes. This study aimed to investigate the relationship between tetracycline resistance (Tet-R) and genotype in 31 isolates from caries-active patients.

Methods: The tetracycline susceptibility of isolates was determined using the agar spot test and the genetic characteristics associated with tetracycline resistance using whole-genome sequencing (WGS). Read More

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http://dx.doi.org/10.1186/s13756-019-0483-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360694PMC
February 2019

Using the best available data to estimate the cost of antimicrobial resistance: a systematic review.

Antimicrob Resist Infect Control 2019 1;8:26. Epub 2019 Feb 1.

4University of Chichester, West Sussex, UK.

Background: Valuation of the economic cost of antimicrobial resistance (AMR) is important for decision making and should be estimated accurately. Highly variable or erroneous estimates may alarm policy makers and hospital administrators to act, but they also create confusion as to what the most reliable estimates are and how these should be assessed. This study aimed to assess the quality of methods used in studies that quantify the costs of AMR and to determine the best available evidence of the incremental cost of these infections. Read More

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http://dx.doi.org/10.1186/s13756-019-0472-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359818PMC
February 2019
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Pneumonia in hospitalized neurologic patients: trends in pathogen distribution and antibiotic susceptibility.

Antimicrob Resist Infect Control 2019 1;8:25. Epub 2019 Feb 1.

1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea.

Background: Bed-ridden state, dysphagia, altered mental state, or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes of pneumonia in neurologic patients may differ from those in the general population, resulting in a different pathogen distribution. We investigated the trends of pathogen distribution in culture-positive pneumonia in hospitalized neurologic patients and the related antibiotic resistance in those with hospital-acquired pneumonia (HAP). Read More

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http://dx.doi.org/10.1186/s13756-019-0475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359823PMC
February 2019
6 Reads

Assessment of early onset surface damage from accelerated disinfection protocol.

Antimicrob Resist Infect Control 2019 31;8:24. Epub 2019 Jan 31.

1School of Materials Engineering, Purdue University, 701 W. Stadium Avenue, West Lafayette, IN 47907 USA.

Background: The objective of this study was to evaluate the extent and potential mechanisms of early onset surface damage from simulated wiping typical of six-months of routine disinfection and to assess the subsequent microbial risk of surfaces damaged by disinfectants.

Methods: Eight common material surfaces were exposed to three disinfectants and a neutral cleaner (neutral cleaner, quaternary ammonium, hydrogen peroxide, sodium hypochlorite) in accelerated aging tests to simulate a long-term disinfection routine. Materials were also immersed in dilute and concentrated chemical solutions to induce surface damage. Read More

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http://dx.doi.org/10.1186/s13756-019-0467-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357435PMC
January 2019
9 Reads

Determinants of antibiotic prescribing behaviors of primary care physicians in Hubei of China: a structural equation model based on the theory of planned behavior.

Antimicrob Resist Infect Control 2019 30;8:23. Epub 2019 Jan 30.

1School of Medicine and Health Management, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei China.

Background: Over-prescription of antibiotics is prevalent all over the world, contributing to the development of antibiotic resistance. The importance of understanding how physicians prescribe antibiotics is increasingly highlighted for the purpose of promoting good practice. This study aimed to identify factors that shape the antibiotic prescribing behaviors of physicians in primary care based on the theory of planned behavior (TPB). Read More

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http://dx.doi.org/10.1186/s13756-019-0478-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354420PMC
January 2019

The impact of the national action plan on the epidemiology of antibiotic resistance among 352,238 isolates in a teaching hospital in China from 2015 to 2018.

Antimicrob Resist Infect Control 2019 29;8:22. Epub 2019 Jan 29.

5Clinical Science Team, Clinton Health Access Initiative, 383 Dorchester Ave, Boston, MA 02127 USA.

Background: We sought to understand the epidemiology and characteristics of antimicrobial resistance (AMR) and the impact of the National Action Plan (NAP) on AMR. This information will be critical to develop interventions and strengthen antibiotic stewardship in hospital settings in China.

Methods: Cross-sectional data collection from the hospital information management system from 1 January 2015 to 30 August 2018. Read More

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http://dx.doi.org/10.1186/s13756-019-0473-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352357PMC
January 2019
10 Reads

Catheter-related bloodstream infections with coagulase-negative staphylococci: are antibiotics necessary if the catheter is removed?

Antimicrob Resist Infect Control 2019 29;8:21. Epub 2019 Jan 29.

1Department of Infectious Diseases, University Hospital Bern, Freiburgstrasse, 3010 Bern, Switzerland.

Background: Catheter-related bloodstream infections (CRBSI) with coagulase-negative Staphylococci (CoNS) are a common source of hospital-acquired bloodstream infections. The main objective of this study was to elucidate the role of systemic antibiotic therapy in the setting of catheter removal in adult patients with CoNS-CRBSI.

Methods: We conducted a retrospective cohort study on patients with CoNS-CRBSI diagnosed between 2008 and 2016 with follow-up for up to 12 months. Read More

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http://dx.doi.org/10.1186/s13756-019-0474-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352346PMC
January 2019
1 Read

Infection control link nurses in acute care hospitals: a scoping review.

Antimicrob Resist Infect Control 2019 28;8:20. Epub 2019 Jan 28.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Background: Involving link nurses in infection prevention and control is a strategy to improve clinical practice that has been implemented in hospitals worldwide. However, little is known about the use, the range and benefits of this strategy. We aimed to identify key concepts of infection control link nurses (ICLN) and ICLN programs, to evaluate the effect of such programs, and to identify gaps in the evidence base. Read More

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http://dx.doi.org/10.1186/s13756-019-0476-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348687PMC
January 2019
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Using local clinical and microbiological data to develop an institution specific carbapenem-sparing strategy in sepsis: a nested case-control study.

Antimicrob Resist Infect Control 2019 25;8:19. Epub 2019 Jan 25.

1Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 RC, Leiden, The Netherlands.

Background: From a stewardship perspective it is recommended that antibiotic guidelines are adjusted to the local setting, accounting for the local epidemiology of pathogens. In many settings the prevalence of Gram-negative pathogens with resistance to empiric sepsis therapy is increasing. How and when to escalate standard sepsis therapy to a reserve antimicrobial agent, is a recurrent dilemma. Read More

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http://dx.doi.org/10.1186/s13756-019-0465-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347774PMC
January 2019
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Antimicrobial susceptibility and genotyping of isolates in Beijing, China, from 2014 to 2016.

Antimicrob Resist Infect Control 2019 24;8:18. Epub 2019 Jan 24.

1National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping District, Beijing, 102206 China.

Background: The presence of macrolide-resistant has been frequently reported in recent years, especially in China. In this study, we investigated the antimicrobial susceptibility and genotype against isolates from 2014 to 2016, Beijing.

Methods: We investigated the activities of four antibiotics against 81  isolates in vitro All isolates were amplification of domains II and V of the 23S rRNA gene and the L4 and L22 ribosomal protein fragments. Read More

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http://dx.doi.org/10.1186/s13756-019-0469-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346583PMC
January 2019
10 Reads

Assessing the social cost and benefits of a national requirement establishing antibiotic stewardship programs to prevent infection in US hospitals.

Antimicrob Resist Infect Control 2019 22;8:17. Epub 2019 Jan 22.

1Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention (CDC), Roybal Campus, 1600 Clifton Road MS H16-3, Atlanta, GA 30329-4027 USA.

Backgound: Economic evaluations of interventions to prevent healthcare-associated infections in the United States rarely take the societal perspective and thus ignore the potential benefits of morbidity and mortality risk reductions. Using new Department of Health and Human Services guidelines for regulatory impact analysis, we developed a cost-benefit analyses of a national multifaceted, in-hospital infection prevention program (including staffing an antibiotic stewardship program) that incorporated value of statistical life estimates to obtain economic values associated with morbidity and mortality risk reductions.

Methods: We used a net present value model to assess costs and benefits associated with antibiotic stewardship programs. Read More

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http://dx.doi.org/10.1186/s13756-018-0459-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343309PMC
January 2019

Emergence of vancomycin-resistant enterococci in Switzerland: a nation-wide survey.

Antimicrob Resist Infect Control 2019 17;8:16. Epub 2019 Jan 17.

Department of Infectious Diseases, Bern University Hospital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland.

This nation-wide survey on the epidemiology of vancomycin-resistant enterococci (VRE) included 142 healthcare institutions and showed an increasing number of VRE colonizations and infections in Switzerland, probably for the most part due to nosocomial dissemination. The introduction and spread of a new clone, gaps in VRE screening policies as well as heterogeneity regarding the management of VRE clusters may be possible explanations. Read More

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http://dx.doi.org/10.1186/s13756-019-0466-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337856PMC
January 2019
6 Reads

Point prevalence survey of peripheral venous catheter usage in a large tertiary care university hospital in Germany.

Antimicrob Resist Infect Control 2019 17;8:15. Epub 2019 Jan 17.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Hygiene and Environmental Medicine, Berlin, Germany.

Background: Bloodstream infections (BSI) are among the most frequently documented healthcare-associated infections (HAI). Central and peripheral venous catheters (CVC and PVC) are relevant risk factors for BSI. Although the risk for BSI is higher for CVC, PVC are utilized more frequently and are therefore relevant in the context of HAI prevention. Read More

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http://dx.doi.org/10.1186/s13756-019-0468-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335674PMC
January 2019
19 Reads

The potential of visible blue light (405 nm) as a novel decontamination strategy for carbapenemase-producing enterobacteriaceae (CPE).

Antimicrob Resist Infect Control 2019 17;8:14. Epub 2019 Jan 17.

1NIHR Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital, B15 2GW, Birmingham, UK.

Background: Carbapenemase-producing (CPE) pose a considerable threat to modern medicine. New treatment options and methods to limit spread need to be investigated. Blue light (BL) is intrinsically antimicrobial, and we have previously demonstrated significant antimicrobial effects on biofilms of a panel of isolates, including two CPEs. Read More

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http://dx.doi.org/10.1186/s13756-019-0470-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335786PMC
January 2019

Effects of an antimicrobial stewardship intervention on perioperative antibiotic prophylaxis in pediatrics.

Antimicrob Resist Infect Control 2019 15;8:13. Epub 2019 Jan 15.

1Division of Pediatric Infectious Diseases, Department for Woman and Child Health, University of Padua, Padua, Italy.

Purpose: This study aims to determine the effectiveness of an Antimicrobial Stewardship Program based on a Clinical Pathway (CP) to improve appropriateness in perioperative antibiotic prophylaxis (PAP).

Materials And Methods: This pre-post quasi-experimental study was conducted in a 12 month period (six months before and six months after CP implementation), in a tertiary Pediatric Surgical Centre. All patients from 1 month to 15 years of age receiving one or more surgical procedures were eligible for inclusion. Read More

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http://dx.doi.org/10.1186/s13756-019-0464-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334390PMC
January 2019
1 Read