153,710 results match your criteria Antiepileptic Drugs


Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Feb 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
February 2019

Antiepileptic therapy approaches in KCNQ2 related epilepsy: A systematic review.

Eur J Med Genet 2019 Feb 13. Epub 2019 Feb 13.

Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr. von Haunersches Children's Hospital, LMU Munich, Lindwurmstraße4, 80337, Munich, Germany; Comprehensive Epilepsy Center for Children, Adolescents and Adults, LMU Munich, Lindwurmstraße 4, 80337, Munich, Germany. Electronic address:

Background: KCNQ2 related disorders comprise both benign seizure disorders and early onset epileptic encephalopathies. Especially within the latter group, patients suffer from refractory seizures to standard antiepileptic drugs and developmental delay. Besides the hope of personalized medical approaches to treat the recently unraveled large amount of genetic channelopathies, there are sparse systematic data on treatment responses in KCNQ2 related epilepsy in larger cohorts. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.02.001DOI Listing
February 2019

Risk factors and control of seizures in 778 Chinese patients undergoing initial resection of supratentorial meningiomas.

Neurosurg Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

This retrospective study explored the risk factors for the occurrence of seizures in the pre- and postoperative period in patients undergoing supratentorial meningiomas surgery to investigate those who are likely to benefit from prophylactic antiepileptic drugs (AEDs). We reviewed the medical records of 778 supratentorial meningiomas patients who were operated at our institution between 2011 and 2012. A total of 100 (12. Read More

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http://dx.doi.org/10.1007/s10143-019-01085-5DOI Listing
February 2019

Collaboration of Care for Women with Epilepsy in their Reproductive Years.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

2 New York University School of Medicine, New York, New York.

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. Read More

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http://dx.doi.org/10.1089/jwh.2018.7506DOI Listing
February 2019

Nonadherence to Antiepileptic Medications: Still a Major Issue to be Addressed in the Management of Epilepsy.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):106-112

Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia.

Context: Medication nonadherence is a significant barrier in achieving seizure freedom in patients with epilepsy. There is a deficiency of data about the reasons for nonadherence in Saudi population.

Aims: The aim of this study is to prove the existence of nonadherence to antiepileptic drugs (AEDs) in patients with epilepsy and identify the responsible factors. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_136_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337980PMC
February 2019

Morvan's syndrome treated successfully with rituximab and lacosamide.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

We describe a woman with both central and peripheral nervous system symptoms consistent with Morvan's syndrome who was successfully treated with immunosuppression including rituximab and the new antiepileptic drug lacosamide against peripheral nerve hyperexcitability. Despite being over 8 months in hospital and 4 months in an intensive care unit she recovered fully. It is also the first case where cerebrospinal fluid neurofilament-light (NfL) levels were followed during the disease course. Read More

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http://dx.doi.org/10.1136/bcr-2018-226832DOI Listing
February 2019

Pins and PNES: Systematic content analysis of Pinterest for information on psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychiatry, Cleveland Clinic, United States of America.

Pinterest is a visual search based, the fourth largest social networking site in the U.S. with 81% of its users being women. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.020DOI Listing
February 2019

Association Between HLA Genotype and Cutaneous Adverse Reactions to Antiepileptic Drugs Among Epilepsy Patients in Northwest China.

Front Neurol 2019 29;10. Epub 2019 Jan 29.

Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.

This study aimed to investigate the association between HLA genotypes and antiepileptic drug-induced cutaneous adverse reactions (AEDs-cADRs) among patients with epilepsy in Ningxia Hui Autonomous Region of Northwest China. Fifteen patients with AEDs-cADRs and 30 matched AEDs tolerant controls from anested case-control study were tested the HLA-A, HLA-B, and HLA-DRB1 genotype using the polymerase chain reaction sequence-based typing (PCR-SBT). Significant difference was not observed between AEDs-cADRs and AEDs tolerant groups in terms of HLA-A, HLA-B, and HLA-DRB1 genotype frequencies. Read More

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http://dx.doi.org/10.3389/fneur.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362303PMC
January 2019
2 Reads

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019

Neurologic Conditions: Dizziness and Vertigo.

FP Essent 2019 Feb;477:29-39

University of South Alabama College of Medicine Department of Family Medicine, 1601 Center Street, 2N Mobile, AL 36604.

Dizziness is seen frequently in patients in the family medicine and emergency department settings. The differential diagnosis of dizziness can be expansive but with a targeted history and physical examination, a correct diagnosis often can be established and appropriate treatment offered. Common etiologies of dizziness include hypotension, benign paroxysmal positional vertigo (BPPV), and Meniere disease. Read More

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February 2019

Neurologic Conditions: New-Onset Seizures in Adults.

FP Essent 2019 Feb;477:22-28

University of South Alabama College of Medicine Department of Family Medicine, 1601 Center Street, 2N Mobile, AL 36604.

Family physicians may be the first point of contact for adults with new-onset seizure. There are many etiologies of seizures in adults. Etiologies of provoked seizures include temporary metabolic disturbances, central nervous system infections, cerebrovascular disease, drug withdrawal, and traumatic brain injury. Read More

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February 2019
1 Read

Treatment of Juvenile Myoclonic Epilepsy in Patients of Child-Bearing Potential.

CNS Drugs 2019 Feb 11. Epub 2019 Feb 11.

Epilepsy Unit, Hôpital Gui de Chauliac, 80 Avenue Fliche, 34295, Montpellier Cedex 05, France.

Juvenile myoclonic epilepsy (JME) is both a frequent and a very characteristic epileptic syndrome with female preponderance. Treatment of JME in women of childbearing potential must consider multiple factors such as desire for pregnancy, use of contraception, seizure control and previously used antiepileptic drugs (AEDs). Approximately 85% of cases are well controlled with valproate, which remains the reference AED in JME but is nowadays considered unsafe for the expecting mother and her fetus. Read More

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http://link.springer.com/10.1007/s40263-018-00602-2
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http://dx.doi.org/10.1007/s40263-018-00602-2DOI Listing
February 2019
2 Reads

Role of the Angiotensin Pathway and its Target Therapy in Epilepsy Management.

Int J Mol Sci 2019 Feb 8;20(3). Epub 2019 Feb 8.

Department of Pharmacy, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo.

Despite extensive research on epileptogenesis, there is still a need to investigate new pathways and targeted therapeutic approaches in this complex process. Inflammation, oxidative stress, neurotoxicity, neural cell death, gliosis, and blood⁻brain barrier (BBB) dysfunction are the most common causes of epileptogenesis. Moreover, the renin⁻angiotensin system (RAS) affects the brain's physiological and pathological conditions, including epilepsy and its consequences. Read More

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http://dx.doi.org/10.3390/ijms20030726DOI Listing
February 2019

Emergency Management of Epilepsy and Seizures.

Semin Neurol 2019 Feb 11;39(1):73-81. Epub 2019 Feb 11.

Department of Neurology, Columbia University Medical Center, New York, New York.

Seizure- and epilepsy-related complications are a common cause of emergency medical evaluation, accounting for 5% of 911 calls and 1% of emergency department visits. Emergency physicians and neurologists must be able to recognize and treat seizure- and epilepsy-related emergencies. This review describes the emergency evaluation and management of new onset seizures, breakthrough seizures in patients with known epilepsy, status epilepticus, acute symptomatic seizures, and acute adverse effects of antiepileptic drugs. Read More

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http://dx.doi.org/10.1055/s-0038-1677008DOI Listing
February 2019
1 Read

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions.

ACS Catal 2019 Feb 7;9(2):1503-1513. Epub 2019 Jan 7.

Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Chiral γ-aminobutyric acid (GABA) analogues represent abundantly prescribed drugs, which are broadly applied as anticonvulsants, as antidepressants, and for the treatment of neuropathic pain. Here we report a one-pot two-step biocatalytic cascade route for synthesis of the pharmaceutically relevant enantiomers of γ-nitrobutyric acids, starting from simple precursors (acetaldehyde and nitroalkenes), using a tailor-made highly enantioselective artificial "Michaelase" (4-oxalocrotonate tautomerase mutant L8Y/M45Y/F50A), an aldehyde dehydrogenase with a broad non-natural substrate scope, and a cofactor recycling system. We also report a three-step chemoenzymatic cascade route for the efficient chemical reduction of enzymatically prepared γ-nitrobutyric acids into GABA analogues in one pot, achieving high enantiopurity (e. Read More

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http://dx.doi.org/10.1021/acscatal.8b04299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366683PMC
February 2019

Adjunctive Perampanel Oral Suspension in Pediatric Patients From ≥2 to <12 Years of Age With Epilepsy: Pharmacokinetics, Safety, Tolerability, and Efficacy.

J Child Neurol 2019 Feb 10:883073819827407. Epub 2019 Feb 10.

12 Formerly: Eisai Neurology Business Group, Eisai Inc., Woodcliff Lake, NJ, USA.

Study 232, an open-label pilot study with an extension phase, evaluated the pharmacokinetics and preliminary safety/tolerability and efficacy of adjunctive perampanel oral suspension (≤0.18 mg/kg/d) in epilepsy patients aged ≥2 to <12 years. Patients were grouped into cohorts 1 (aged ≥7 to <12 years) and 2 (aged ≥2 to <7 years). Read More

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http://dx.doi.org/10.1177/0883073819827407DOI Listing
February 2019
1 Read

Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.

Cochrane Database Syst Rev 2019 Feb 8;2:CD003032. Epub 2019 Feb 8.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, P.le L.A. Scuro, 10, Verona, Verona, Italy, 37134.

Background: This is an updated version of the Cochrane Review previously published in 2017.Absence seizures (AS) are brief epileptic seizures which present in childhood and adolescence. Depending on clinical features and electroencephalogram (EEG) findings they are divided into typical, atypical absences, and absences with special features. Read More

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http://dx.doi.org/10.1002/14651858.CD003032.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367681PMC
February 2019

Lidocaine and carbamazepine inhibit while phenytoin and lamotrigine paradoxically enhance the insect neuromuscular transmission.

Invert Neurosci 2019 Feb 8;19(1). Epub 2019 Feb 8.

Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences (IEPHB RAS), 44 Thorez Prospect, St. Petersburg, Russia, 194223.

Primary mechanism of action of local anesthetics and various anticonvulsants is the voltage-gated sodium channel block. Many of these small molecules also have other targets in nervous system of vertebrates. However, little is known about their action on invertebrate nervous system. Read More

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http://dx.doi.org/10.1007/s10158-019-0224-zDOI Listing
February 2019

Switching medication products during the treatment of psychiatric illness.

Int J Psychiatry Clin Pract 2019 Feb 8:1-12. Epub 2019 Feb 8.

d Department of Pharmacology & Therapeutics , McGill University, McIntyre Medical Science Building , Montréal , QC , Canada.

Background: The common practice of switching between branded (reference) medications and their corresponding generic products, between generic products, or even from a generic product to a branded medication during the treatment of central nervous system (CNS) disorders may compromise efficacy and/or tolerability.

Methods: We assessed the published literature from March 1, 2010 through June 30, 2017 via PubMed using the MeSH term 'generics, drugs' alone and in combination with class-specific terms (e.g. Read More

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http://dx.doi.org/10.1080/13651501.2018.1508724DOI Listing
February 2019
1 Read

Epilepsy and traditional healers in the Republic of Guinea: A mixed methods study.

Epilepsy Behav 2019 Feb 4;92:276-282. Epub 2019 Feb 4.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Purpose: The purpose of this study was to characterize the reasons, extent, and impact of traditional medicine use among people with epilepsy (PWE) in the Republic of Guinea.

Methods: Guinea is a low-income country in sub-Saharan Africa (SSA) with limited healthcare resources. People with epilepsy and their caregivers were seen at a public referral hospital in Conakry, the capital city, where they completed semi-structured interviews with physicians regarding their beliefs about epilepsy, medical care, and engagement with traditional healers. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.017DOI Listing
February 2019

Disseminated cysticercosis in an immunocompetent individual.

Ann Afr Med 2019 Jan-Mar;18(1):51-53

Department of General Medicine, Saveetha Medical College, Saveetha University, Chennai, Tamil Nadu, India.

Cysticercosis is a major public health problem, particularly in developing countries. It is caused by the larvae of the cestode Taenia solium (pork tapeworm). It usually presents as a solitary lesion in the muscle or brain (neurocysticercosis). Read More

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http://dx.doi.org/10.4103/aam.aam_76_17DOI Listing
February 2019
1 Read

Use of Newer Anticonvulsants for the Treatment of Status Epilepticus.

Pharmacotherapy 2019 Feb 5. Epub 2019 Feb 5.

University of Illinois at Chicago, Department of Pharmacy Practice, Chicago, IL.

Status Epilepticus (SE) has a high mortality rate and is one of the most common neurological emergencies. Fast progression of this neurological emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. The objective of this paper was to evaluate the efficacy and safety of AEDs released to the market after 2000 for SE, refractory SE (RSE), and super refractory SE (SRSE). Read More

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http://dx.doi.org/10.1002/phar.2229DOI Listing
February 2019

Augmented Renal Clearance.

Pharmacotherapy 2019 Feb 5. Epub 2019 Feb 5.

University of Kentucky, College of Pharmacy - Pharmacy Practice and Science, Lexington, Kentucky.

Augmented renal clearance (ARC) is a phenomenon in critically ill patients characterized by increased creatinine clearance and elimination of renally-eliminated medications. Patients with severe neurologic injury, sepsis, trauma, and burn have been consistently identified as at risk for ARC, with mean creatinine clearances ranging from 170 ml/min to over 300 ml/min. Several potential mechanisms may contribute to the occurrence of ARC including endogenous responses to increased metabolism and solute production, alterations in neurohormonal balance, and therapeutic maneuvers such as fluid resuscitation. Read More

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http://dx.doi.org/10.1002/phar.2231DOI Listing
February 2019
1 Read

Seizures in Children with HIV infection in South Africa: A retrospective case control study.

Seizure 2019 Jan 28;65:159-165. Epub 2019 Jan 28.

University of Cape Town Neuroscience Institute, Faculty of Health Sciences, Anzio Road, Observatory, Cape Town 7295 South Africa; Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Klipfontein Road, Rondebosch, Cape Town, 7700 South Africa. Electronic address:

Purpose: Data relating to the role that Human immunodeficiency virus (HIV) contributes towards seizures in HIV-infected children is limited. The management of seizures in this group is complex due to potential interactions between antiseizure medication and antiretroviral therapies. This study explores the seizure semiology and course of a population of affected children based on questions raised from a previous epidemiological study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183041
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http://dx.doi.org/10.1016/j.seizure.2019.01.023DOI Listing
January 2019
4 Reads

Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure.

BMC Ophthalmol 2019 Feb 4;19(1):42. Epub 2019 Feb 4.

Eye Institute, Eye and Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, People's Republic of China.

Background: To compare the protective effects of the histone deacetylase inhibitors (HDACis) β-hydroxybutyrate (βOHB), trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) on human lens epithelial cells(HLECs) following ultraviolet-B (UVB) exposure.

Methods: HLECs were divided into subgroups: four HDACi groups, a control group, a UVB-treated group and a DMSO group (cells treated with DMSO and UVB irradiation). In the HDACi groups, HLECs were cultured with different concentrations of HDACis 12 h prior to UVB irradiation. Read More

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http://dx.doi.org/10.1186/s12886-019-1056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360693PMC
February 2019
1 Read

Is Bioequivalence Established Based on the Reference-Scaled Average Bioequivalence Approach Relevant to Chronic Administration of Phenytoin? Perspectives Based on Population Pharmacokinetic Modeling and Simulations.

J Clin Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

Phenytoin demonstrates time-dependent and nonlinear pharmacokinetics (PK) within the therapeutic range of 10 to 20 μg/mL. There are discussions on the relevance of bioequivalence (BE) demonstrated in a single-dose BE study in healthy subjects to exposure under chronic use conditions in patients, particularly given that phenytoin has a narrow therapeutic index. The objective of this study was to quantitatively evaluate the appropriateness of single-dose PK BE through simulations for the phenytoin extended-capsule products. Read More

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http://dx.doi.org/10.1002/jcph.1380DOI Listing
February 2019

AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.

PLoS One 2019 4;14(2):e0211644. Epub 2019 Feb 4.

Oscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, Germany.

Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary. While clinical guidelines recommend all approved anticonvulsants, so far it is still unclear which of the available drugs is the best therapeutic option for treating glioma-associated seizures, also in view of possible anti-tumorigenic effects. In our study, we employed four patient-derived low-passage cell lines of glioblastoma and three cell lines of brain metastases, and challenged these cultures with four anticonvulsants with different mechanisms of action: levetiracetam, valproic acid, carbamazepine and perampanel. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211644PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361447PMC
February 2019
2 Reads

Is There an Association Between Antiepileptic Drug Use and Dementia Risk? A Case-Control Study.

J Alzheimers Dis 2019 Jan 28. Epub 2019 Jan 28.

Epidemiology, IQVIA, Frankfurt, Germany.

Background: Previous research has found a positive association between the use of antiepileptic drugs (AEDs) and dementia. However, there have been some concerns about the generalizability of its findings.

Objective: The goal of this case-control study was to analyze the association between AED use and dementia risk in Germany. Read More

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http://dx.doi.org/10.3233/JAD-181194DOI Listing
January 2019
2 Reads

Independent role of neonatal seizures in subsequent neurological outcomes: a population-based study.

Dev Med Child Neurol 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurology, Stanford University School of Medicine, Palo Alto, California, USA.

Aim: This population-based study aimed to estimate the impact of neonatal seizures on subsequent neurological outcomes, regardless of underlying etiology.

Method: We performed a retrospective cohort study (1st January 2009-31st December 2014), using a USA nationwide claims database. Newborn infants enrolled in 2009 were followed for up to 6 years. Read More

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http://dx.doi.org/10.1111/dmcn.14174DOI Listing
February 2019
1 Read

Drug interactions with dementia-related pathophysiological pathways worsen or prevent dementia.

Br J Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Univlille, INSERM, CHU de Lille, Degenerative and vascular cognitive disorders, Lille, F-59000.

Many risk factors are known to induce or precipitate dementia. Drugs acting via different mechanisms can modulate cognitive performance and exert either beneficial or deleterious effects on cognition through functional or neuropathological mechanisms. This review discusses the association between several classes of drugs and cognitive impairment and dementia risk. Read More

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http://dx.doi.org/10.1111/bph.14607DOI Listing
February 2019
1 Read

Risk factors for seizure recurrence in a pediatric observation unit.

Am J Emerg Med 2019 Jan 25. Epub 2019 Jan 25.

Hacettepe University Medical Faculty, Department of Pediatrics, Division of Pediatric Neurology, Ankara, Turkey.

Background: Most patients present with seizures to pediatric emergency department (PED) are observed for extended periods for the risk of possible acute recurrence.

Objective: The aim of this study is to determine the risk factors of acute recurrence within first 24 h.

Methods: Patients who presented to PED with seizure during past 24 h were enrolled. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.042DOI Listing
January 2019

Essential Tremor.

Authors:
Stephen G Reich

Med Clin North Am 2019 Mar;103(2):351-356

Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3rd Floor, Baltimore, MD 21201, USA. Electronic address:

Essential tremor is one of the most common movement disorders. It is characterized by a bilateral action tremor of the upper limbs. It may be accompanied by tremor of the head, voice, or lower limbs. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.016DOI Listing

Seizures and Epilepsy.

Authors:
Emily L Johnson

Med Clin North Am 2019 Mar 3;103(2):309-324. Epub 2018 Dec 3.

Department of Neurology, Johns Hopkins School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address:

Epilepsy affects 65 million people worldwide, and is a leading neurologic cause of loss of quality-adjusted life years. The diagnosis of seizures and epilepsy often depends on a careful history, and is supported with electroencephalogram and imaging. First-line treatment of epilepsy includes medical management. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00257125183012
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http://dx.doi.org/10.1016/j.mcna.2018.10.002DOI Listing
March 2019
11 Reads

Current pharmacotherapy options for conduct disorders in adolescents and children.

Expert Opin Pharmacother 2019 Jan 31:1-13. Epub 2019 Jan 31.

h Townsville Clinical School, College of Medicine and Dentistry , James Cook University , Townsville , Australia.

Introduction: Conduct disorder (CD) is a common mental health disorder of childhood and adolescence. CD's complexity, with its heterogenous clinical manifestations and overlapping comorbidities makes the application of evidence-based management approaches challenging. This article aims to combine a systematic review of the available literature, with a consensus opinion from both child and adolescent psychiatrists and developmental pediatricians on the clinical and pharmacological management of children and adolescents with conduct disorder (CD). Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1561862DOI Listing
January 2019
7 Reads

THE RESTLESS LEGS SYNDROME (REVIEW).

Georgian Med News 2018 Dec(285):74-81

Institute of Neurology and Neuropsychology, Tbilisi; Caucasus International University, Tbilisi; Ilia State University, Tbilisi, Georgia; Department of Psychiatry and Psychotherapy, University of Regensburg, Germany.

The restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a common sleep related neurological disorder with prevalence between 1 and 10%, increasing with age. Women are more frequently affected than men. RLS is characterized by an urge to move the legs accompanied by uncomfortable and unpleasant sensations in the legs, worsening of complaints during periods of rest, improvement by movement and an increase of symptoms in the evening or at night. Read More

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December 2018
3 Reads

[Pharmacogenetic markers of metabolic disorders in the treatment with valproic acid].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):82-89

Bekhterev National Medical Research Center of Psychiatry and Neurology, St.-Petersburg, Russia.

The review includes studies on the association between the use of VA drugs and weight gain in patients with epilepsy as well as other valproate-induced adverse drug reactions, including insulin resistance. Understanding the mechanisms of significant weight gain of patients taking VA drugs will help personalize antiepileptic therapy and minimize the risk of valproate-induced obesity. Read More

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http://dx.doi.org/10.17116/jnevro201811810282DOI Listing
January 2018
1 Read

Pressure pain assessment may predict the outcome of spinal cord stimulation for refractory epilepsy.

Am J Clin Exp Immunol 2018 20;7(6):95-99. Epub 2018 Dec 20.

Department of Anesthesiology, People's Hospital of Hainan Province Haikou, Hainan, PR China.

It was well-documented that epilepsy and pain arise from an excitation-inhibition imbalance within neuronal networks. A previous meta-analysis of data from clinical trials showed an association between anticonvulsants and specific pain types, e.g. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334195PMC
December 2018

Clozapine augmentation strategies - a systematic meta-review of available evidence. Treatment options for clozapine resistance.

J Psychopharmacol 2019 Jan 30:269881118822171. Epub 2019 Jan 30.

1 Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Germany.

Background:: Treatment options for clozapine resistance are diverse whereas, in contrast, the evidence for augmentation or combination strategies is sparse.

Aims:: We aimed to extract levels of evidence from available data and extrapolate recommendations for clinical practice.

Methods:: We conducted a systematic literature search in the PubMed/MEDLINE database and in the Cochrane database. Read More

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http://dx.doi.org/10.1177/0269881118822171DOI Listing
January 2019

Pharmacotherapeutic strategies for treating binge eating disorder. Evidence from clinical trials and implications for clinical practice.

Expert Opin Pharmacother 2019 Jan 29:1-12. Epub 2019 Jan 29.

a Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.

Introduction: Binge eating disorder (BED) is the most common eating disorder and was newly recognized in 2013 in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). BED is frequently associated with obesity and the metabolic syndrome, as well as with other psychiatric diseases, such as mood (49%), anxiety (41%), and substance use (22%) disorders. BED is highly prevalent and carries a high burden of mental and physical illness and disability. Read More

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http://dx.doi.org/10.1080/14656566.2019.1571041DOI Listing
January 2019
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[Acceptance, demand, reasons for consultation and outcome of counseling on epilepsy in Hesse and Lower Franconia].

Nervenarzt 2019 Jan 29. Epub 2019 Jan 29.

Epilepsiezentrum Frankfurt Rhein-Main, Zentrum der Neurologie und Neurochirurgie, Goethe-Universität Frankfurt, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland.

Background And Aim: The diagnosis of epilepsy is often accompanied by relevant restrictions for patients, which may result in disease-specific daily problems that need targeted and professional counseling. Specialized epilepsy counseling services (ECS) were introduced in some German states since 1996 to provide an additional and independent service for epilepsy-related problems. The objective of this prospective, multicenter cohort study at six ECS was to determine and analyze the acceptance, demand and frequent reasons for consultation in Hesse and Lower Franconia. Read More

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http://dx.doi.org/10.1007/s00115-019-0676-8DOI Listing
January 2019

Sedation induced by antiepileptic drugs polytherapy: A note of caution during anesthesia.

Saudi J Anaesth 2019 Jan-Mar;13(1):86-87

Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/sja.SJA_711_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329230PMC
January 2019
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Newer Antiepileptic Drugs Discontinuation due to Adverse Effects: An Observational Study.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):27-30

Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aims: Antiepileptic drugs are the main therapy for epilepsy. However, the incidence of adverse effects (AEs) results in treatment discontinuation. The aim of this study is evaluating the factors involved in discontinuation of antiepileptic drugs. Read More

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http://www.annalsofian.org/text.asp?2019/22/1/27/248505
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http://dx.doi.org/10.4103/aian.AIAN_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327699PMC
January 2019
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Epilepsy in Children with Autistic Spectrum Disorder.

Children (Basel) 2019 Jan 25;6(2). Epub 2019 Jan 25.

Department of Pediatrics and Medical Genetics, Medical University-Plovdiv,4000, Bulgaria.

The comorbidity of autistic spectrum disorder (ASD) and epilepsy has been widely discussed but many questions still remain unanswered. The aim of this study was to establish the occurrence of epilepsy among children with ASD to define the type of epileptic seizures and syndromes, the age of onset of epilepsy, EEG abnormalities, the used antiepileptic drugs and the therapeutic responses for seizures and autistic behavior, as well as to find some correlations between epilepsy and gender, etiology and intellectual disability (ID). A retrospective study of medical files of 59 patients (aged 1⁻18 years) with ASD during a 5-year period was performed. Read More

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http://dx.doi.org/10.3390/children6020015DOI Listing
January 2019
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Effectiveness of Pregabalin for Treatment of Burning Mouth Syndrome.

Clin Psychopharmacol Neurosci 2019 Feb;17(1):139-142

Department of Neurology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey.

Treatment of burning mouth syndrome (BMS) is challenging because there is no consensus regarding pharmalogical or nonpharmalogical therapies. The use of anticonvulsants is controversial. We present nine patients BMS who respond to pregabalin. Read More

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http://dx.doi.org/10.9758/cpn.2019.17.1.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361046PMC
February 2019

Selected Clinical Features of Coccidioidomycosis in Dogs.

Med Mycol 2019 Feb;57(Supplement_1):S67-S75

School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Canine coccidioidomycosis, a systemic fungal infection endemic to arid and semiarid regions of North, Central, and South America, is commonly diagnosed in dogs living in or traveling through lower Sonoran life zones in the states of California and Arizona. Canine and human cases have geographic overlap. Similarities between clinical coccidioidomycosis in dogs and humans include asymptomatic infection, primary respiratory disease and disseminated disease. Read More

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https://academic.oup.com/mmy/article/57/Supplement_1/S67/530
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http://dx.doi.org/10.1093/mmy/myy113DOI Listing
February 2019
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