155,899 results match your criteria Antiepileptic Drugs


Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Brain responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) are emergent noninvasive markers of neuronal excitability and effective connectivity in humans. However, the underlying physiology of these TMS-evoked EEG potentials (TEPs) is still heavily underexplored, impeding a broad application of TEPs to study pathology in neuropsychiatric disorders. Here we tested the effects of a single oral dose of three antiepileptic drugs with specific modes of action (carbamazepine, a voltage-gated sodium channel (VGSC) blocker; brivaracetam, a ligand to the presynaptic vesicle protein VSA2; tiagabine, a gamma-aminobutyric acid (GABA) reuptake inhibitor) on TEP amplitudes in 15 healthy adults in a double-blinded randomized placebo-controlled crossover design. Read More

View Article
December 2018

Carnitine deficiency in epileptic children treated with a diversity of anti-epileptic regimens.

Egypt J Neurol Psychiatr Neurosurg 2018 21;54(1):37. Epub 2018 Nov 21.

Faculty of Medicine, Fayoum University, Fayoum City, 63611 Egypt.

Background: Carnitine deficiency is relatively common in epileptic patients. The risk factors reported include the combination of valproic acid with other antiepileptic drugs (AEDs), young age, multiple neurologic disabilities, non-ambulatory status, and being underweight.

Objectives: To study the level of carnitine deficiency and its associated risk factors among a group of children with idiopathic epilepsy treated with different AEDs. Read More

View Article
November 2018
1 Read

Robot-assisted stereoelectroencephalography in children.

Authors:

J Neurosurg Pediatr 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEThe goal in the study was to describe the clinical outcomes associated with robot-assisted stereoelectroencephalography (SEEG) in children.METHODSThe authors performed a retrospective, single-center study in consecutive children with medically refractory epilepsy who were undergoing robot-assisted SEEG. Kaplan-Meier survival analysis was used to calculate the probability of seizure freedom. Read More

View Article
December 2018

Demonstration of the effect of brivaracetam on an experimental epilepsy model

Turk J Med Sci 2018 12 12;48(6):1315-1320. Epub 2018 Dec 12.

Department of Neurosurgery, Faculty of Medicine, Dumlupınar University Kütahya, Turkey

Background/aim: The aim of this study was to investigate the effects of valproic acid (VPA) and a new-generation antiepileptic drug called brivaracetam (BRV) on the brain damage occurring after status epilepticus (SE) in rats.

Materials And Methods: In our study, an experimental animal model of SE, generated by stereotaxically injecting 0.4–2 μg of kainic acid into the rat hippocampus, was used. Read More

View Article
December 2018

Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy.

Front Neurosci 2018 27;12:796. Epub 2018 Nov 27.

Department of Medical Imaging, Jinling Hospital, Southern Medical University, Nanjing, China.

The objective was to study the modulation effects of levetiracetam on the fMRI activation/deactivation patterns associated with centrotemporal spikes (CTS) in Rolandic epilepsy. Forty patients with Rolandic epilepsy, including levetiracetam-medicated patients ( = 20) and drug-naive patients ( = 20), were studied. Single and sequential hemodynamic response functions-based EEG-fMRI analysis was performed to detect dynamic activation/deactivation associated with CTS. Read More

View Article
November 2018

Diagnostic exome sequencing in 100 consecutive patients with both epilepsy and intellectual disability.

Epilepsia 2018 Dec 7. Epub 2018 Dec 7.

Department of Human Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: Epilepsy is highly prevalent among patients with intellectual disability (ID), and seizure control is often difficult. Identification of the underlying etiology in this patient group is important for daily clinical care. We assessed the diagnostic yield of whole exome sequencing (WES). Read More

View Article
December 2018

Lacosamide at therapeutic concentrations induces histone hyperacetylation in vitro.

Epilepsia Open 2018 Dec 30;3(4):535-539. Epub 2018 Oct 30.

Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel.

Inhibition of histone deacetylases (HDACs) and subsequent hyperacetylation of histone proteins lead to altered gene expression associated with therapeutic drug effects, but also with teratogenicity. The only US Food and Drug Administration (FDA)-approved antiepileptic drug that has been consistently shown to induce histone hyperacetylation is valproic acid. More recently, lacosamide was reported to interfere with histone modifications, but histone hyperacetylation was not demonstrated. Read More

View Article
December 2018

A retrospective observational study of EEG findings and antiepileptic drug use among children referred for EEG to Zambia's University Teaching Hospital.

Epilepsia Open 2018 Dec 16;3(4):503-510. Epub 2018 Oct 16.

Epilepsy Division Department of Neurology University of Rochester Rochester New York U.S.A.

Objective: Despite the heavy burden of epilepsy in Sub-Saharan Africa, there remains a relative paucity of neurophysiology services and limited published data on electroencephalography (EEG) features among African children. The aim of this study was to describe clinical characteristics, EEG findings, and antiepileptic drug (AED) use among children referred for EEG to the University Teaching Hospital in Zambia.

Methods: EEG referrals and reports from 2013-2015 were reviewed. Read More

View Article
December 2018

Progress in Developing Pharmacologic Agents to Treat Bulimia Nervosa.

CNS Drugs 2018 Dec 6. Epub 2018 Dec 6.

Lindner Center of HOPE, Mason, OH, USA.

This paper reviews past and current progress in developing pharmacologic agents for the treatment of individuals with bulimia nervosa (BN). We searched the literature and clinical trial registries for compounds studied in BN, the related condition, binge eating disorder (BED), and preclinical models of binge-eating behavior. Drug classes evaluated included antidepressants, antiepileptic drugs, stimulants and other medications for attention-deficit/hyperactivity disorder, opioid antagonists, and weight loss agents, among others. Read More

View Article
December 2018

Mortality & recurrent seizure risk after new-onset seizure in HIV-positive Zambian adults.

BMC Neurol 2018 Dec 7;18(1):201. Epub 2018 Dec 7.

Epilepsy Division, Department of Neurology, University of Rochester School of Medicine & Dentistry, 265 Crittenden Blvd, CU420694, Rochester, NY, 14642-0694, USA.

Background: Recurrent seizure risks in HIV-positive people with new-onset seizure are largely unknown, making it challenging to offer optimal recommendations regarding antiepileptic drug (AED) initiation. Existing outcomes data is limited, and risk factor identification requires a diagnostic assessment, which is often unavailable in regions heavily effected by HIV, like sub-Saharan Africa.

Methods: HIV-positive Zambian adults with new-onset seizure were enrolled in a prospective cohort study to determine seizure recurrence and risk factors for recurrence. Read More

View Article
December 2018

Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex.

Ann Pharmacother 2018 Dec 7:1060028018818785. Epub 2018 Dec 7.

3 Michigan Medicine, Ann Arbor, MI, USA.

Background: Recommended loading doses (LDs) of phenytoin and fosphenytoin range from 10 to 25 mg/kg. Few studies have examined the LD requirements in male versus female patients and in patients who are obese.

Objectives: To examine the influence of obesity and sex on phenytoin LDs. Read More

View Article
December 2018

New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

View Article
December 2018
1 Read

Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus.

Neural Regen Res 2019 Mar;14(3):480-484

Department of Neurology, Children's Hospital of Chongqing Medical University; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders; Ministry of Education Key Laboratory of Child Development and Disorders; Key Laboratory of Pediatrics in Chongqing, Chongqing, China.

Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. Read More

View Article
March 2019
1 Read

The possible effect of SCN1A and SCN2A genetic variants on carbamazepine response among Khyber Pakhtunkhwa epileptic patients, Pakistan.

Ther Clin Risk Manag 2018 21;14:2305-2313. Epub 2018 Nov 21.

Institute of Basic Medical Science, Khyber Medical University, Peshawar, Khyber Pakhtunkhwa, Pakistan,

Purpose: > and > gene encodes α subunit of the neuronal voltage-gated sodium channel, which is a target for carbamazepine (CBZ). Recent studies have demonstrated that polymorphism of > and > was associated with use of CBZ. However, it has not been determined whether the polymorphism affects CBZ or other antiepileptic drug responsiveness. Read More

View Article
November 2018

Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.

J Neural Transm (Vienna) 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.

Increasing evidence indicates that some antiarrhythmic drugs play a pivotal role in seizures, not only in vivo studies on animals, but also in clinical trials. Some of these antiarrhythmic drugs potentiate or alleviate the anticonvulsant action of the classical antiepileptic drugs. The aim of this study was to determine the influence of dronedarone (DRO-a multichannel blocker belonging to the class III of antiarrhythmic drugs) on the anticonvulsant effects of four standard antiepileptic drugs (carbamazepine, phenobarbital, phenytoin and valproate) in the tonic-clonic seizure model in mice. Read More

View Article
December 2018

The clinical and imaging features of gray matter heterotopia: a clinical analysis on 15 patients.

Neurol Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.

Objective: To investigate the clinical and imaging features of gray matter heterotopia (GMH) and improve the clinicians' understanding of the disease.

Methods: A retrospective study was performed on 15 patients with GMH diagnosed at The Affiliated Hospital of Xuzhou Medical University from November 2014 to November 2016. Their clinical and imaging features are also summarized. Read More

View Article
December 2018
1.495 Impact Factor

Delayed onset of severe chronic pain in CASPR2 autoantibody-associated Morvan syndrome in a former UK swine abattoir worker.

Pain Rep 2018 Sep-Oct;3(5):e675. Epub 2018 Sep 17.

Neurology, Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.

Introduction: Autoantibody-mediated autoimmunity directed against targets within the voltage-gated potassium channel complex (VGKCC autoantibodies) has been implicated in causing neuropathic pain.

Methods: We report the case of a 76-year-old, United Kingdom male who was diagnosed with contactin-associated protein 2 (CASPR2) autoantibody-associated Morvan syndrome, a rare neurological condition.

Results: He had previously worked in a swine abattoir; exposure to aerosol within swine abattoirs has been reported to elicit an immune response resulting in the production of these autoantibodies; however, unusually, his manifestations emerged with several years' latency. Read More

View Article
September 2018

Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model.

Front Mol Neurosci 2018 26;11:378. Epub 2018 Nov 26.

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the brain. Previous studies have shown that mutations in the () gene cause a familial, fever-associated epilepsy syndrome. It is unclear as to whether the gene also correlates with other stimulations such as flashing and/or mediates the effects of antiepileptic drugs. Read More

View Article
November 2018

Editorial: New Directions in the Management of Status Epilepticus.

Front Neurol 2018 23;9:994. Epub 2018 Nov 23.

Department of Neuroscience and Experimental Therapeutics, Texas A&M University College of Medicine, Bryan, TX, United States.

View Article
November 2018

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.

Authors:

Nat Commun 2018 12 10;9(1):5269. Epub 2018 Dec 10.

The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely epilepsy genes at these loci, with the majority in genetic generalized epilepsies. Read More

View Article
December 2018

[DEPDC5, a new key to understand various epilepsies].

Authors:
Saeko Ishida

Nihon Yakurigaku Zasshi 2018 ;152(6):281-285

Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU).

Epilepsy is one of the most frequent neurological disorders characterized by spontaneous and recurrent seizures. Most seizures last for the lifetime and the patients require long term therapies. However, about 30% of the patients are refractory to antiepileptic drugs. Read More

View Article
January 2018

[Function of synaptic vesicle protein 2A (SV2A) as a novel therapeutic target for epilepsy].

Nihon Yakurigaku Zasshi 2018 ;152(6):275-280

Department of Pharmacology, Osaka University of Pharmaceutical Sciences.

Epilepsy is a chronic neurologic disease characterized by recurrent seizures, affecting nearly 1% of the population. Synaptic vesicle protein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles and is now implicated in the pathogenesis of epileptic disorders. This is because 1) Sv2a-knockout mice exhibit severe seizures, 2) SV2A serves as a specific binding site for certain antiepileptics (e. Read More

View Article
January 2018

[Epileptogenesis mediated by glial cells].

Nihon Yakurigaku Zasshi 2018 ;152(6):268-274

Department of Pediatrics, Interdisciplinary Graduate School of Medicine, University of Yamanashi.

Epilepsy is one of the most common diseases of the central nervous system. Many epilepsies are controllable because of the existence of different antiepileptic drugs with multiple mechanisms of action. However, about 30% of epilepsy is so-called refractory epilepsy in which existing drugs do not show enough therapeutic effects. Read More

View Article
January 2018

Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity.

Neural Regen Res 2019 Jan;14(1):34-38

Department of Anatomy and Cell Biology, Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Read More

View Article
January 2019

KCNQ2 mutation in an infant with encephalopathy of infancy with migrating focal seizures.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics (Neurology), McMaster University, 1280 Main St., W. Hamilton, Ontario L8S 4K1, Canada.

A male neonate presented with seizures at 18 hours of life, characterized by tonic posturing with eye deviation to the right, apnoea, bradycardia, and oxygen desaturation. Initial structural, metabolic, and infectious work-up was unremarkable. He continued to have seizures refractory to a variety of antiepileptic medications. Read More

View Article
December 2018

Intractable apnoeic seizures in a child with a deletion typically associated with Williams syndrome.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Division of Pediatric Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto.

Williams-Beuren syndrome is rarely associated with epilepsy. One previously reported case showed an association with apnoeic seizures while a few other cases showed an association with infantile epileptic spasms and generalized and focal seizures. We report the case of a 13-month-old boy with a deletion typically associated with Williams-Beuren syndrome, who presented with isolated apnoeic seizures which were refractory to multiple antiepileptic drugs but partially responsive to the ketogenic diet. Read More

View Article
December 2018

Risk factors for the use of antiepileptic drugs in patients with psychogenic nonepileptic seizures.

Epilepsy Behav 2018 Dec 7;90:119-121. Epub 2018 Dec 7.

Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The aim of this study was to investigate the frequency of antiepileptic drug (AED) use in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical risk factors that may be associated with such a practice.

Methods: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were studied. Patients with concomitant epilepsy or abnormal Electroencephalogram (EEG) were not included. Read More

View Article
December 2018

Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.

Biomed Pharmacother 2018 Dec 5;110:409-419. Epub 2018 Dec 5.

Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, 44519, Egypt. Electronic address:

Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. Read More

View Article
December 2018
2.023 Impact Factor

Retention rate of first antiepileptic drug in poststroke epilepsy: A nationwide study.

Seizure 2018 Nov 23;64:29-33. Epub 2018 Nov 23.

Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Sweden. Electronic address:

Purpose: To describe the retention rates of first antiepileptic drugs (AEDs) in patients with poststroke epilepsy on a nationwide scale.

Methods: The Swedish Stroke Register, which has 94% coverage and high-resolution data on stroke, comorbidities, and disability, was cross-referenced to the National Patient Register, Drug Register, and Cause-of-Death Register. Patients with onset of AED-treated epilepsy after stroke in 2005-2010 were included. Read More

View Article
November 2018

Substitution has better efficacy than add-on therapy for patients with focal epilepsy after their first antiepileptic drug treatments fail.

Seizure 2018 Dec 1;64:23-28. Epub 2018 Dec 1.

Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, PR China. Electronic address:

Purpose: This study is to compare the efficacy of substitution with add-on therapy in patients with focal epilepsy, whose first monotherapy has failed after receiving usual treatments.

Methods: This is a prospective, long-term, non-randomized observational cohort study. Data were collected from Wenzhou Epilepsy Follow Up Registry Database. Read More

View Article
December 2018

A pilot study of levonorgestrel concentrations and bleeding patterns in women with epilepsy using a levonorgestrel IUD and treated with antiepileptic drugs.

Contraception 2018 Dec 4. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York City, NY 10032, USA. Electronic address:

Objectives: We explored levonorgestrel (LNG) concentrations, bleeding patterns and endometrial thickness in women with epilepsy (WWE) initiating a LNG-intrauterine device (IUD) co-administered with antiepileptic drugs (AEDs).

Study Design: This pilot study included 20 WWE ages 18 to 45 years with well-controlled seizures and stable AED regimens initiating a 52 mg LNG-IUD (20mcg/d initial release). We collected blood and measured endometrial thickness before IUD placement and 21 days, 3 and 6 months thereafter. Read More

View Article
December 2018

Seizures after Stereotactic Radiosurgery for Benign Supratentorial Meningiomas: An uncontrollable type of seizure?

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: We investigated seizure outcomes of patients with supratentorial meningiomas (ST-MNGs) treated with stereotactic radiosurgery (SRS).

Methods: One hundred and thirty-three patients with a total of 144 ST-MNGs, who were treated with SRS between 2009 and 2016, were included in this study. The mean age was 59. Read More

View Article
December 2018

Treatment options in pediatric super-refractory status epilepticus.

Brain Dev 2018 Dec 7. Epub 2018 Dec 7.

Division of Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand. Electronic address:

Background: Super-refractory status epilepticus (SRSE) is a seizure that continues >24 h after anesthesia, or recurs on the reduction of anesthesia. SRSE is extremely difficult-to-control and associated with poor outcome. To date, optimal therapy and outcome data in children is limited. Read More

View Article
December 2018

Therapeutic strategies for treating epilepsy during pregnancy.

Expert Opin Pharmacother 2018 Dec 10:1-10. Epub 2018 Dec 10.

a Department of Neurology , Beaumont Hospital , Dublin , Ireland.

Introduction: Counseling for women with epilepsy of childbearing potential surrounding pregnancy issues is of the utmost importance and should be done when antiepileptic medications are prescribed and reviewed regularly at clinic visits. Physicians must be familiar with risks associated with antiepileptic medication, and endeavor to minimize risks to a fetus while selecting best medications for epilepsy type. Areas covered: The authors discuss the role of folic acid, updated evidence relating to the occurrence of major congenital malformations and neurocognitive risks associated with antiepileptic medication. Read More

View Article
December 2018

A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood.

Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.

Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More

View Article
December 2018
13 Reads

An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders.

Authors:
Ashish Dhir

Expert Opin Investig Drugs 2018 Dec 6. Epub 2018 Dec 6.

a Department of Neurology , School of Medicine, University of California Davis , Sacramento , CA , USA.

Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase (COX) is one of the principal drug targets for the reduction of neuroinflammation; however, studies have yielded mixed results for COX-inhibitors in the treatment of diverse acute and chronic models of epilepsy. Areas covered: The article covers the effects of COX-inhibitors in epilepsy disorders. Read More

View Article
December 2018
2 Reads

Oriental Herbal Medicine for Neurological Disorders in Children: An Overview of Systematic Reviews.

Am J Chin Med 2018 Dec 6:1-26. Epub 2018 Dec 6.

* Department of Pediatrics of Korean Medicine, Kyung Hee University, Korean Medicine Hospital at Gangdong, Seoul 05278, Republic of Korea.

Oriental herbal medicine (OHM) has been widely used in pediatric neurological disorders and has attracted attention as a safe and effective treatment. We aim to summarize and evaluate the evidence for OHM in pediatric neurological disorders for evidence-based decision-making. Without language restrictions, up-to-date research data were obtained from nine electronic databases. Read More

View Article
December 2018
3 Reads

Patient-level medication regimen complexity in an adolescent and adult population with autism spectrum disorders.

Pharmacotherapy 2018 Dec 3. Epub 2018 Dec 3.

The Ohio State University, Center for Biostatistics, 320-43 Lincoln Tower, 1800 Cannon Drive, Columbus, OH, 43210.

Background: Adults with autism spectrum disorder (ASD) frequently experience polypharmacy. However, there is limited understanding of how to quantify medication complexity in this vulnerable population.

Objective: This study examined medication administration difficulty using the Medication Regimen Complexity Index (MRCI) tool in adolescents and adults with ASD. Read More

View Article
December 2018
2.662 Impact Factor

Perampanel in patients with brain tumour-related epilepsy in real-life clinical practice: a retrospective analysis.

Int J Neurosci 2018 Dec 3:1-10. Epub 2018 Dec 3.

e Biostatistic Unit, Regina Elena National Cancer Institute , Rome , Italy.

Introduction: Epilepsy occurs in 35-70% of patients with gliomas; glutamate plays a central role via AMPA-receptor activation, which is involved both in seizure activity and tumor growth. We conducted a retrospective study on brain tumour-related epilepsy patients (BTRE) treated with perampanel in add-on (PER) for 12 months, to evaluate efficacy and tollerability, according to real-life clinical practice.

Materials And Methods: Medical records of eleven patients (9 males, mean age 54 years) with glioma and epilepsy treated with PER in add-on, for inadequate seizure control or adverse events (AEs) from previous antiepileptic drugs (AEDs) therapy, were reviewed. Read More

View Article
December 2018
1 Read

BRIVA-LIFE - a multicentre retrospective study of the long-term use of brivaracetam in clinical practice.

Acta Neurol Scand 2018 Dec 1. Epub 2018 Dec 1.

Infanta Leonor Hospital, Madrid, Spain.

Objectives: Evaluate long-term effectiveness and tolerability of brivaracetam in clinical practice in patients with focal epilepsy.

Materials And Methods: This was a multicentre retrospective study. Patients aged ≥16 years were started on brivaracetam from November 2016 to June 2017 and followed over 1 year. Read More

View Article
December 2018
1 Read

Design, synthesis and anticonvulsant evaluation of fluorinated benzyl amino enaminones.

Bioorg Med Chem 2018 Nov 24. Epub 2018 Nov 24.

Department of Chemistry, Tennessee State University, Nashville, TN 37209-1561, United States. Electronic address:

Inspite of progress made for the discovery of novel antiepileptic drugs, epilepsy remains an unmet medical need. We synthesized nine trifluoromethylated enaminone derivatives and tested them for their anticonvulsant activity using maximal electroshock seizure (MES) test, subcutaneous pentylenetetrazole (scPTZ) test, and rotorod test for neurotoxicity. Among the compounds tested 3-(4-fluoro-3-(trifluomethyl)benzylamino)-5-(trifluoromethyl)cyclohex-2-enone (4f) showed ED of 23. Read More

View Article
November 2018
2 Reads

An Opportunity to Report Closer-to-Efficacy Findings in a Study of Lamotrigine for Borderline Personality Disorder.

Authors:
Eric G Smith

Am J Psychiatry 2018 Dec;175(12):1265

From the Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers VA Medical Center, Bedford, Mass.; and the Departments of Psychiatry and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.

View Article
December 2018
1 Read

No Effect of Lamotrigine in Subgroups of Patients With Borderline Personality Disorder: Response to Smith.

Am J Psychiatry 2018 Dec;175(12):1265-1266

From the Centre for Psychiatry, Imperial College London, London; and the Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, U.K.

View Article
December 2018
1 Read

Psychogenic nonepileptic seizures in children and adolescents: An international cross-cultural study.

Epilepsy Behav 2018 Dec 2;90:90-92. Epub 2018 Dec 2.

Children's Comprehensive Epilepsy Center, Alberta Children's Hospital, Calgary, Canada; Alberta Children's Hospital Research Institute, Calgary, Canada; Cumming School of Medicine, University of Calgary, Alberta, Canada. Electronic address:

Purpose: We compared various clinical characteristics of psychogenic nonepileptic seizures (PNES) between young patients from Iran, Saudi Arabia, and Canada, three nations with significantly different socioeconomic and demographic characteristics. This international cross-cultural comparative study may advance our knowledge and understanding of PNES in children and adolescents across the cultures and borders.

Methods: In this retrospective study, we investigated all patients 16 years of age or younger, with PNES admitted to the epilepsy monitoring units at one center in Iran, one center in Saudi Arabia, and one center in Canada. Read More

View Article
December 2018
2 Reads

Status Epilepticus, Refractory Status Epilepticus, and Super-refractory Status Epilepticus.

Continuum (Minneap Minn) 2018 Dec;24(6):1683-1707

Purpose Of Review: Status epilepticus, refractory status epilepticus, and super-refractory status epilepticus can be life-threatening conditions. This article presents an overview of the three conditions and discusses their management and outcomes.

Recent Findings: Status epilepticus was previously defined as lasting for 30 minutes or longer but now is more often defined as lasting 5 minutes or longer. Read More

View Article
December 2018
7 Reads

Effect of Long-term Carbamazepine Therapy on Bone Health.

Med Arch 2018 Oct;72(4):262-266

Neurology Clinic, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.

Introduction: Recent research reported that prolonged use of AET is associated with changes in bone metabolism, with consequent reduction in bone mineral density (BMD) and increased risk of fractures.

Objectives: Therefore, the aim of our study was to investigate the effects of carbamazepine on serum levels of 25 -hydroxyvitamin D and on biomarker of bone formation and resorption (serum levels of osteocalcin).

Material And Methods: We measured serum levels of 25-OHD and osteocalcin (OCLN) in normal controls (n=30) and in epilepsy patients taking carbamazepine (CBZ) (n=50) in monotherapy for a period of at least twelve months. Read More

View Article
October 2018
3 Reads

How safe is switching antiepileptic drug manufacturers?

Authors:
Martin Holtkamp

Nat Rev Neurol 2018 Dec 4. Epub 2018 Dec 4.

Epilepsy-Center Berlin-Brandenburg, Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

View Article
December 2018

Factors contributing to excessive daytime sleepiness in Korean adults with epilepsy: A sleep questionnaire-based study.

Epilepsy Behav 2018 Dec 1;90:61-65. Epub 2018 Dec 1.

Department of Neurology, Gil Medical Center, Gachon Medical School, Incheon, Republic of Korea.

Objectives: We determined factors contributing to excessive daytime sleepiness (EDS) in Korean adults with epilepsy (AWE).

Methods: A total of 147 AWE who had been treated for >1 year were included. Daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). Read More

View Article
December 2018
2 Reads