154,511 results match your criteria Antiepileptic Drugs


Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany.

Seizure 2019 Mar 29;69:92-98. Epub 2019 Mar 29.

Epilepsy Center Hessen and Department of Neurology, Philipps-University Marburg, Marburg (Lahn), Germany; Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany. Electronic address:

Purpose: To identify factors correlating with poorer quality of life (QoL) in children and adolescents with epilepsy and regarding QoL and depression of their caregivers in Germany.

Method: A cross-sectional multicenter study on QoL and depression was performed in two representative German states (Hessen and Schleswig-Holstein). Variance analysis, linear regression, and bivariate correlation were used to identify correlating factors for poorer QoL and symptoms of depression. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183052
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2019.03.016DOI Listing
March 2019
1 Read

Epileptic spasm and other forms of epilepsy in presumed perinatal arterial ischemic stroke in Turkey after more than 10 years follow-up: A single centre study.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Neuroradiology, Istanbul Faculty of Medicine, Istanbul, Turkey.

Purpose: To identify the frequency of epilepsy and whether the association of epilepsy with clinical and neuroimaging findings in children with presumed perinatal arterial ischemic stroke (PPAIS).

Methods: We performed a retrospective analysis of 37 children with PPAIS followed-up at a tertiary referral center between January 1, 2000, and October 31, 2016. Clinical data including demographic features, age at onset of symptoms and seizures, initial clinical presentation, epilepsy features, used antiepileptic drugs, and thrombophilia screening results were abstracted from medical records. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604193009
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2019.04.004DOI Listing
April 2019
1 Read

Influence of salbutamol on the anticonvulsant potency of the antiepileptic drugs in the maximal electroshock-induced seizures in mice.

Pharmacol Rep 2019 Feb 8;71(3):466-472. Epub 2019 Feb 8.

Department of Experimental and Clinical Pharmacology, Medical University, Lublin, Poland.

Background: β-Adrenergic receptor agonists are widely used agents in the treatment of asthma or preterm labor. Since prevalence of asthma was shown to be higher in patients with epilepsy and modulation of noradrenergic system activity may modify epilepsy course, the aim of the present study was to examine the effect of salbutamol (SALB), one of the most commonly used β-adrenergic receptor agonist on the anticonvulsant potency of four classical antiepileptic drugs (AEDs): valproate (VPA), carbamazepine (CBZ), phenytoin (DPH) and phenobarbital (PB) in mice subjected to the maximal electroshock (MES)-induced seizures.

Methods: Seizures were caused by a current delivered through ear-clip electrodes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.02.003DOI Listing
February 2019

Safety aspects of antiepileptic drugs-a population-based study of adverse effects relative to changes in utilisation.

Eur J Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Programme for Pharmacy, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.

Purpose: Antiepileptic drugs (AEDs) are increasingly used, and knowledge about adverse effects is scarce based on clinical studies. The purpose of the present study was to characterise adverse effects reports of AEDs in Norway relative to changes in utilisation in various indications from population-based data to elucidate important safety aspects of use of AEDs.

Methods: Aggregated data of adverse effects reported for AEDs in Norway from the EudraVigilance-database (2004-2013) in addition to indication-specific use of AEDs during 2004-2015 from the Norwegian Prescription Database were used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-019-02678-1DOI Listing
April 2019
1 Read

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing
March 2019
1 Read

Glioblastoma in the elderly.

Geriatr Psychol Neuropsychiatr Vieil 2019 Apr 17. Epub 2019 Apr 17.

Service de neurologie Mazarin, Hôpital Pitié-Salpêtrière, Paris, France.

Incidence of malignant gliomas is growing in the elderly population. Unfortunately, increasing age is one of the most important negative prognostic factors in gliomas. However, the previous nihilistic approach is progressively changing towards more active strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/pnv.2019.0799DOI Listing
April 2019
2 Reads

Drug-drug interactions between antiepileptics and cannabinoids.

Expert Opin Drug Metab Toxicol 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Pathophysiology , Medical University of Lublin , Lublin , Poland.

Introduction: About 40% of patients with epilepsy are associated with drug-resistant seizures, therefore there has been a continuous search for novel treatment approaches. In experimental studies, natural and synthetic cannabimimetic compounds alone or combined with antiepileptic drugs (AEDs) have been extensively studied and cannabidiol, a naturally occurring compound, has been involved in a number of clinical trials. Areas covered: The authors have performed a literature search (PubMed database up to December 2018) for studies evaluating interactions between AEDs and cannabinoid receptor ligands in experimental models of seizures. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/17425255.2019.1
Publisher Site
http://dx.doi.org/10.1080/17425255.2019.1605355DOI Listing
April 2019
2 Reads

Design, synthesis, in silico ADMET profile and GABA-A docking of novel phthalazines as potent anticonvulsants.

Arch Pharm (Weinheim) 2019 Apr 15:e1800387. Epub 2019 Apr 15.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

A new series of 2-substituted-2,3-dihydrophthalazine-1,4-diones (2- 9) were designed and synthesized to evaluate their anticonvulsant activity. The neurotoxicity was assessed using the rotarod test. Molecular docking was performed for the synthesized compounds to assess their binding affinities as γ-aminobutyric acid A (GABA-A) receptor agonists as a possible mechanism of their anticonvulsant action, to rationalize their anticonvulsant activity in a qualitative way. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ardp.201800387DOI Listing
April 2019
1 Read

[Cutaneous Adverse Drug Reaction Caused by Antiepileptic Drug].

Brain Nerve 2019 Apr;71(4):401-406

Department of Dermatology, Niigata University Graduate School of Medical and Dental Sciences.

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug induced hypersensitivity syndrome (DIHS) are severe cutaneous adverse reactions, which can be life-threatening and lead to severe sequelae. Antiepileptic drugs frequently cause severe adverse reactions in the form of. It is important to understand the characteristics of each disease and attempt at early diagnosis. Read More

View Article

Download full-text PDF

Source
https://webview.isho.jp/journal/detail/abs/10.11477/mf.14162
Publisher Site
http://dx.doi.org/10.11477/mf.1416201284DOI Listing
April 2019
2 Reads

Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy.

J Affect Disord 2019 Apr 8;252:201-211. Epub 2019 Apr 8.

Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA; Department of Internal Medicine, Division of Translational Informatics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address:

Background: This study compared the largest set of bipolar disorder pharmacotherapies to date (71 drugs and drug combinations) for risk of kidney disorders (KDs).

Methods: This retrospective observational study used the IBM MarketScan® database to analyze data on 591,052 adults with bipolar disorder without prior nephropathy, for onset of KDs (of "moderate" or "high" severity) following psychopharmacotherapy (lithium, mood stabilizing anticonvulsants [MSAs], antipsychotics, antidepressants), or "No drug". Cox regression models included fixed pre-treatment covariates and time-varying drug exposure covariates to estimate the hazard ratio (HR) of each treatment versus "No drug". Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.04.009DOI Listing
April 2019
1 Read

Highly-sensitive UHPLC-DAD method for simultaneous determination of two synergistically-acting antiepileptic drugs: Application to pharmaceutical tablets and human urine.

Biomed Chromatogr 2019 Apr 15:e4554. Epub 2019 Apr 15.

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

A simple and highly sensitive Ultra High-performance Liquid Chromatographic -Diode array detection method (UHPLC-DAD) was developed and validated for the simultaneous estimation of levetiracetam (LEV) and lacosamide (LAC). It was clinically proven that the combination of LEV and LAC exhibits a synergistic effect against refractory seizures in mice, which was the motivation for the analysis of this binary mixture both in bulk and human urine samples. The binary mixture was resolved on a Hypersil BDS C analytical column, utilizing a mobile phase of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bmc.4554DOI Listing

Can short-term video-EEG substitute long-term video-EEG monitoring in psychogenic nonepileptic seizures? A prospective observational study.

Epilepsy Behav 2019 Apr 10;94:258-263. Epub 2019 Apr 10.

Department of Psychiatry, Government Medical College, Surat, India.

Background: Psychogenic nonepileptic seizures (PNES), the commonest nonepileptic event, represent 20-30% of drug-resistant epilepsy. Correct identification of PNES avoids unnecessary hospitalization and exposure of antiepileptic drugs (AEDs), and helps implement appropriate psychological treatment. Long-term video-electroencephalography (LTVEEG) is the gold standard test to diagnose PNES. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.034DOI Listing
April 2019
2 Reads

Evaluation of seizure treatment in anti-LGI1, anti-NMDAR, and anti-GABAR encephalitis.

Neurology 2019 Apr 12. Epub 2019 Apr 12.

From the Departments of Neurology (M.A.A.M.d.B., A.v.S., M.H.v.C.-H., A.E.M.B., P.A.E.S.S., M.J.T.), Immunology (M.W.J.S.), and Pediatric Neurology (R.F.N.), Erasmus MC University Medical Center, Rotterdam; Haga Hospital (A.v.S.), the Hague; Department of Neurology (R.P.W.R., M.H.J.M.M.), Maastricht UMC+, Maastricht; Department of Neurology (C.A.v.D.), Maasstad Hospital, Rotterdam; Department of Neurology (M.J.M.M.), Academic Center of Epileptology Kempenhaeghe; Sophia Children's Hospital (R.F.N.), Rotterdam; Department of Neurology (R.D.T.), Stichting Epilepsie Instellingen Nedederland (SEIN), Heemstede; and Department of Neurology (R.D.T.), Leiden University Medical Center (LUMC), the Netherlands.

Objective: This nationwide cohort study evaluates seizure responses to immunotherapy and antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti-NMDA receptor (NMDAR), and anti-gamma-aminobutyric-acid B receptor (GABAR) encephalitis.

Methods: Anti-LGI1, anti-NMDAR, and anti-GABAR encephalitis patients with new-onset seizures were included. Medical information about disease course, AEDs and immunotherapies used, effects, and side effects were collected. Read More

View Article

Download full-text PDF

Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000007475DOI Listing
April 2019
4 Reads

Parental stress in pediatric epilepsy after therapy withdrawal.

Epilepsy Behav 2019 Apr 9;94:239-242. Epub 2019 Apr 9.

Child and Adolescent Neuropsychiatry, Medical School, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, SA, Italy.

Objective: The objective of the study was to explore stress levels in the parents of children with idiopathic epilepsy at different time points of the disease, specifically, at the time of diagnosis, during follow-up, and 1 and 2 years after discontinuation of antiepileptic drugs.

Methods: Our study included 50 patients between 5 and 14 years of age, who were diagnosed with childhood absence epilepsy or idiopathic focal epilepsy with Rolandic paroxysms. Parents of the participants independently completed the Parenting Stress Index-Short Form at the time of initial diagnosis, and when the children started antiepileptic drugs (Time 0), and at 1 year (Time 1) and 2 years (Time 2) after discontinuation of therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.029DOI Listing
April 2019
1 Read

Somatic comorbidity in Polish patients with epilepsy.

Pol Arch Intern Med 2019 Apr 12. Epub 2019 Apr 12.

INTRODUCTION A range of somatic and psychiatric disorders occurs frequently in patients with epilepsy (PWE), which adds to the burden of epilepsy. OBJECTIVES To estimate the prevalence and risk factors of somatic comorbidities and  analyze the extent of somatic co-medication in adult PWE. PATIENTS AND METHODS This study involved PWE treated in university epilepsy clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20452/pamw.14794DOI Listing
April 2019
1 Read

Maternal epilepsy and behavioral development of the child: Family factors do matter.

Epilepsy Behav 2019 Apr 8;94:222-232. Epub 2019 Apr 8.

Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands; Research Institute of Child Development and Education, University of Amsterdam, the Netherlands. Electronic address:

Purpose: The purpose of the study was to examine whether mothers with epilepsy experience family problems and to investigate the possible mediating role of distinct family factors in the relationship between maternal epilepsy and child behavioral problems, in which it is also investigated whether more proximal family factors mediate the more distal family factors.

Methods: In an observational study, with children identified from the European Registry of Antiepileptic Drugs and Pregnancy database in the Netherlands (EURAP-NL), parents completed questionnaires on maternal epilepsy, family factors (proximal, distal, contextual, global), and child behavior. Hierarchical multilevel regression analyses were performed to examine the relative contribution of epilepsy-related and family factors on child internalizing and externalizing problems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.030DOI Listing
April 2019
1 Read

Seizure characteristics, treatment, and outcome in autoimmune synaptic encephalitis: A long-term study.

Epilepsy Behav 2019 Apr 8;94:198-203. Epub 2019 Apr 8.

Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Objectives: The objective of this study was to report seizure characteristics, long-term outcome, and potential factors associated with persistent seizures in patients with autoimmune synaptic encephalitis (ASE).

Method: Clinical data and courses of 52 patients with ASE who presented with seizures at the Department of Neurology of the First Hospital of Jilin University from January 2015 to August 2017 were reviewed. Seizure outcomes were assessed with a median follow-up duration of 30 months (8-40 months). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2018.10.038DOI Listing
April 2019
1 Read

Synthesis, in vivo anticonvulsant testing, and molecular modeling studies of new nafimidone derivatives.

Drug Dev Res 2019 Apr 11. Epub 2019 Apr 11.

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, Turkey.

An estimated 50 million people suffer epilepsy worldwide and 30% of the cases do not respond to current antiepileptic drugs (AEDs). Here, we report synthesis and anticonvulsant screening of new derivatives of nafimidone, a well-known member of (arylakyl)azole anticonvulsants. The compounds showed promising protection against maximal electroshock (MES)-induced seizures in mice and rats when administered via intraperitoneal (ip) and oral route. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ddr.21538DOI Listing
April 2019
1 Read

Visuospatial learning and memory in children pre- and posttemporal lobe resection: Patterns of localization and lateralization.

Epilepsy Behav 2019 Apr 7;94:189-194. Epub 2019 Apr 7.

Department of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada; Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

In children with epilepsy, the impact of surgery including or sparing the mesial temporal lobes (TLs) on visuospatial memory has not been thoroughly investigated, and a clear pattern of hemispheric lateralization has not been observed. The primary aim of this study was to examine visuospatial learning and memory outcomes in children with epilepsy prior to and one year after surgical excision, to determine whether outcomes differed as a function of the localization and lateralization of surgical excisions. Forty-six children who underwent unilateral TL surgery with sparing of the mesial structures (TL group, N = 21, 16 left) or including mesial structures (TL + M group, N = 25 children, 12 left) were retrospectively recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.031DOI Listing
April 2019
1 Read

Vitamin B12 and Folate Status in Patients with Epilepsy Under Levetiracetam Monotherapy.

Int J Prev Med 2019 5;10:32. Epub 2019 Mar 5.

Isfahan Center of Health Research, National Institute of Health Research, Isfahan, Iran.

Background: Antiepileptic drugs (AEDs) may lead to an increase in the plasma concentration of homocysteine. There is limited information, especially from Iran, regarding the risk in patients who are treated with levetiracetam as a new type of AED. The aim of the present study was to investigate the effect of levetiracetam on plasma homocysteine, vitamin B12, and folate levels in adult patients with epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijpvm.IJPVM_71_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425766PMC

Efficacy and safety of Levetiracetam as adjunctive treatment in children with focal onset seizures: A systematic review and meta-analysis.

Epilepsy Res 2019 Apr 3;153:40-48. Epub 2019 Apr 3.

College of Pharmacy, Jinan University, Guangzhou, 510632, China; Institute of Dongguan-Jinan University, Dongguan, 523808, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Jinan University, Guangzhou, 510632, China. Electronic address:

Objective: To assess the efficacy and safety of levetiracetam (LEV) as adjunctive treatment in children (0-18 years) with focal-onset seizures (FOS) with a larger dataset.

Methods: A pooled analysis would be performed for prospective clinical trials and a meta-analysis for controlled studies. Retrospectives studies were also summarized using descriptive statistics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2019.04.001DOI Listing
April 2019
1 Read

Differences in emergency department care of adults with a first epileptic seizure versus a recurrent seizure: a study of the ACESUR (Acute Epileptic Seizures in the Emergency Department) registr.

Emergencias 2019 Abr;31(2):91-98

Hospital Universitario Miguel Servet, Zaragoza, España.

Objectives: To describe the characteristics of care received by patients who come to the emergency department with a first epileptic seizure versus a recurrent seizure in a patient with diagnosed epileps.

Material And Methods: ACESUR (Acute Epileptic Seizures in the Emergency Department) is a prospective multicenter, multipurpose registry of cases obtained by systematic sampling on even days in February and July 2017 and on odd days in April and October 2017. Patients were aged 18 years or older and had an emergency department diagnosis of epileptic seizure. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

Weaning from antiseizure drugs after new onset status epilepticus.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Objective: In patients with status epilepticus (SE) without prior epilepsy, there are limited data on the safety of discontinuing antiseizure drugs (ASDs) after seizure control. We aimed to describe seizure recurrence when weaning from ASDs following new onset SE (NOSE).

Methods: Retrospective review of adult patients with NOSE admitted to Mayo Clinic, Rochester, Minnesota between January 1, 1990 and December 31, 2015 was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14730DOI Listing
April 2019
1 Read

Adherence to risk management guidelines for drugs which cause vitamin D deficiency - big data from the Swedish health system.

Drug Healthc Patient Saf 2019 22;11:19-28. Epub 2019 Mar 22.

eHealth Institute, Data Intensive Sciences and Applications (DISA), Department of Medicine and Optometry, Linnaeus University, Kalmar, Sweden,

Purpose: Several medications are known to cause vitamin D deficiency. The aim of this study is to describe vitamin D testing and supplementation in patients using these "risk medications", thereby assessing adherence to medical guidelines.

Patients And Methods: A database with electronic health records for the population in a Swedish County (≈240,000 inhabitants) was screened for patients prescribed the pre-defined "risk medications" during a 2-year period (2014-2015). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/DHPS.S188187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432880PMC

Long-term efficacy and safety of lacosamide and levetiracetam monotherapy in elderly patients with focal epilepsy: A retrospective study.

Epilepsy Behav 2019 Apr 5;94:178-182. Epub 2019 Apr 5.

Epilepsy Center, Department of Systems Medicine, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy. Electronic address:

Objectives: Epilepsy management in elderly patients is often complex because of several concomitant comorbidities that may limit the use of some antiepileptic drugs (AEDs). Levetiracetam (LEV) is a second-generation AED widely used in elderly patients with epilepsy while lacosamide (LCM), which has been recently approved in European Union (EU) as monotherapy for the treatment of focal onset seizures, is affected by a scarcity of data in such frail population. This study is aimed at assessing the efficacy and the tolerability of LCM as monotherapy in elderly patients affected by focal onset epilepsy compared with those receiving LEV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.02.022DOI Listing
April 2019
1 Read

Parental consanguinity in patients with psychogenic nonepileptic seizures.

Epilepsy Behav 2019 Apr 5;94:167-168. Epub 2019 Apr 5.

Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The aim of this study was to investigate the rate of consanguinity of parents of the patients with psychogenic nonepileptic seizures (PNES). This would provide important information for future studies on the potential genetic bases of PNES.

Methods: In this retrospective study, all patients with PNES, who were studied at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were recruited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.03.017DOI Listing

Densidad mineral ósea e indicadores bioquímicos y hormonales en niños con parálisis cerebral cuadripléjica.

Nutr Hosp 2019 Apr 8. Epub 2019 Apr 8.

Nuevo Hospital Civil de Guadalajara.

Introduction: children with cerebral palsy (CP) have multiple risk factors for low bone mineral density or osteoporosis.

Objective: to explore the association between bone mineral density (BMD) and biochemical and hormonal indicators of bone metabolism in children with quadriplegic cerebral palsy (CP).

Methods: a cross-sectional analytical study included 59 participants from six to 18 years of age with quadriplegic CP. Read More

View Article

Download full-text PDF

Source
https://www.nutricionhospitalaria.org/articles/02262/show
Publisher Site
http://dx.doi.org/10.20960/nh.2262DOI Listing
April 2019
5 Reads

Microporous polymer based on the new compound "bi-(4-vinyl phenylquinoline) amide" for enrichment and quantitative determination of lamotrigine in rat and human serum.

Anal Bioanal Chem 2019 Apr 8. Epub 2019 Apr 8.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Lamotrigine is one of the most widely used antiepileptic drugs in the treatment of epilepsy. This kind of drug needs to be used in the long term and should be quantitatively detected in the blood of patients to avoid drug toxicity caused by individual differences and environmental and pathological changes in the process of taking. The detection of antiepileptic drugs in human blood is challenging because of their low contents and the interference of complex matrices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00216-019-01812-3DOI Listing
April 2019
1 Read

Seizures following Intoxication with a Common Antituberculosis Drug.

Case Rep Pediatr 2019 5;2019:8972574. Epub 2019 Mar 5.

Obstetric and Pediatric Intensive Care Unit, Hassan II Academic Hospital, Fez, Morocco.

Isoniazid is an antimycobacterial agent commonly prescribed in most tuberculosis chemotherapy regimens. Its side effects are widely known including mainly liver toxicity and peripheral neuropathy. The toxic effects of isoniazid are dose-related. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/8972574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425408PMC
March 2019
1 Read

Losing Balance Over a Fatty Acid.

Authors:
Christina Gross

Epilepsy Curr 2019 Mar-Apr;19(2):129-131

Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T. J Neurosci. 2018;38(47):10220-10235. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1535759719835664
Publisher Site
http://dx.doi.org/10.1177/1535759719835664DOI Listing
April 2019
2 Reads

Valproic Acid Leads New Neurons Down the Wrong Path.

Authors:
Steve C Danzer

Epilepsy Curr 2019 Mar-Apr;19(2):132-133

Ectopic Neurogenesis Induced by Prenatal Antiepileptic Drug Exposure Augments Seizure Susceptibility in Adult Mice Sakai A, Matsuda T, Doi H, Nagaishi Y, Kato K, Nakashima K. Proc Natl Acad Sci U S A. 2018;115(16):4270-4275. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1535759719835366DOI Listing
April 2019
4 Reads

Don't Fear the Reefer-Evidence Mounts for Plant-Based Cannabidiol as Treatment for Epilepsy.

Authors:
M Scott Perry

Epilepsy Curr 2019 Mar-Apr;19(2):93-95

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O, Patel AD, Cross JH, et al; GWPCARE3 Study Group. N Engl J Med. 2018;378:1888-1897. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1535759719835671DOI Listing
April 2019
6 Reads

Making Rash Decisions in Epilepsy: Evaluating Hypersensitivity Reactions to Anti-seizure Medications.

Epilepsy Curr 2019 Mar-Apr;19(2):96-98

The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study Guvenir H, Dibek Misirlioglu E, Civelek E. J Allergy Clin Immunol Pract. 2018;6(6):2043-2050. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1535759719835672DOI Listing
April 2019
1 Read

Comparative Risk of Major Congenital Malformations With 8 Different Antiepileptic Drugs: A Prospective Cohort Study of the EURAP Registry.

Authors:
David G Vossler

Epilepsy Curr 2019 Mar-Apr;19(2):83-85

Teratogenesis of 8 Antiepileptic Drugs in Multinational Experience Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F for the EURAP Study Group. Lancet Neurol. 2018;17(6):530-538. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1535759719835353DOI Listing
April 2019
1 Read

Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.

Brain Dev 2019 Apr 3. Epub 2019 Apr 3.

Pediatric Neurology and Epileptology Unit, Brotzu Hospital Trust, Cagliari, Italy.

Background: A targeted treatment approach is increasingly promoted in epilepsy management.

Aim: To investigate if etiology (both established or initially presumed) influences antiepileptic drug choice of experts in neonatal seizures.

Methods: An invitation to participate to a web-based questionnaire was sent to Italian pediatric neurologists affiliated to the Italian Society of Pediatric Neurology (SINP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2019.03.012DOI Listing
April 2019
2 Reads

Levels of anger in epilepsy patients treated with eslicarbazepine acetate.

Acta Neurol Scand 2019 Apr 6. Epub 2019 Apr 6.

Epilepsy Unit. Neurology Department. Vall d'Hebron Hospital. Passeig Vall d'Hebron, 119-129. 08035, Barcelona. Spain.

Introduction: Aggressive behavior is commonly associated with epilepsy and, can be influenced by the antiepileptic drugs (AEDs) taken. Sodium channel blockers, specifically the carboxamides derivatives carbamazepine and oxcarbazepine, are some of the AEDs considered to have a favorable psychiatric effect profile.

Objectives: We aimed to assess whether the carboxamide analogue eslicarbazepine acetate (ESL) has any effect on the levels of anger in patients with epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13099DOI Listing
April 2019
1 Read

Antiepileptic drug therapy in the elderly: a clinical pharmacological review.

Acta Neurol Belg 2019 Apr 5. Epub 2019 Apr 5.

Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Seizure disorder is the third most common neurological disorder in the elderly after stroke and dementia. With the increasing geriatric population, the situation of clinicians seeing more and more elderly epilepsy patients is very likely. Not only is the diagnosis of epilepsy tedious in the elderly, its management raises many challenging issues for the treating physicians. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13760-019-01132-4DOI Listing
April 2019
4 Reads

Wide-area all-optical neurophysiology in acute brain slices.

J Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts, USA

Optical tools for simultaneous perturbation and measurement of neural activity open the possibility of mapping neural function over wide areas of brain tissue. However, spectral overlap of actuators and reporters presents a challenge for their simultaneous use, and optical scattering and out-of-focus fluorescence in tissue degrade resolution. To minimize optical crosstalk, we combined an optimized variant (eTsChR) of the most blue-shifted channelrhodopsin reported to-date with a nuclear-localized red-shifted Ca indicator, H2B-jRGECO1a. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0168-19.2019DOI Listing

Identifying drugs that bind selectively to intersubunit general anesthetic sites in the α1β3γ2 GABAR transmembrane domain.

Mol Pharmacol 2019 Apr 5. Epub 2019 Apr 5.

Harvard Medical School;

GABA receptors (GABARs) are targets for important classes of clinical agents (e.g. anxiolytics, anticonvulsants and general anesthetics) that act as positive allosteric modulators (PAMs). Read More

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.118
Publisher Site
http://dx.doi.org/10.1124/mol.118.114975DOI Listing
April 2019
3 Reads

Role of plasma exchange in stiff person syndrome.

Transfus Apher Sci 2019 Mar 19. Epub 2019 Mar 19.

Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA.

Objective: Stiff person syndrome (SPS) is commonly associated with antibodies directed against 65-kDa glutamic acid decarboxylase (GAD65). Therapeutic Plasma Exchange (TPE) has been used as an adjunct therapy in patients who do not respond well to conventional treatment, which includes immunosuppression therapies, anti-anxiety medications, muscle relaxants, anticonvulsants, and pain relievers.

Methods: We retrospectively analyzed the clinical data and outcomes of ten patients with the clinical diagnosis of anti-GAD65 positive SPS in which TPE was employed to improve symptoms refractory to conventional treatment during an eight-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transci.2019.03.015DOI Listing
March 2019
2 Reads

Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy.

Drug Metab Pharmacokinet 2018 Mar 16. Epub 2018 Mar 16.

Sun Yat-sen University, School of Pharmaceutical Sciences, 132 Outer Ring East Road, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China. Electronic address:

Valproic acid (VPA) is used as one of the first-line antiepileptic drugs to control seizure in epilepsy patients. However, one third of patients do not respond to VPA. This study is to investigate the influence of single nucleotide polymorphisms (SNPs) in multidrug transporters on VPA responses in Han Chinese epilepsy patients on VPA monotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dmpk.2018.01.006DOI Listing
March 2018
1 Read

Quantitative ultrasound and apoptotic death in the neonatal primate brain.

Neurobiol Dis 2019 Apr 2;127:554-562. Epub 2019 Apr 2.

Department of Neurology, University of Wisconsin, School of Medicine, Madison, WI, USA. Electronic address:

Apoptosis is triggered in the developing mammalian brain by sedative, anesthetic or antiepileptic drugs during late gestation and early life. Whether human children are vulnerable to this toxicity mechanism remains unknown, as there are no imaging techniques to capture it. Apoptosis is characterized by distinct structural features, which affect the way damaged tissue scatters ultrasound compared to healthy tissue. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09699961193008
Publisher Site
http://dx.doi.org/10.1016/j.nbd.2019.03.032DOI Listing
April 2019
5 Reads

Hypersensitivity reactions to antiepileptic drugs in children.

Pediatr Allergy Immunol 2019 Apr 5. Epub 2019 Apr 5.

University of Belgrade-Faculty of Medicine, Belgrade, Serbia.

Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting and benign but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13055DOI Listing
April 2019
2 Reads

The Effect of Non-Gabapentinoid Anticonvulsants on Sensorimotor Recovery After Human Spinal Cord Injury.

CNS Drugs 2019 Apr 4. Epub 2019 Apr 4.

School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.

Background: Recent observational studies have shown an association between gabapentinoid anticonvulsants and greater motor recovery after spinal cord injury. There is preclinical evidence to suggest that other anticonvulsants, such as sodium channel blockers, may also confer beneficial effects.

Purpose: The aim of the current study was to determine if non-gabapentinoid anticonvulsants were associated with neurological recovery after acute, traumatic spinal cord injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40263-019-00622-6DOI Listing

Uncertain Effectiveness of Prophylactic Anticonvulsive Medication in Predicting Cognitive Outcome of Neurosurgical Patients.

World Neurosurg 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Objectives: To evaluate the influence of prophylactic anticonvulsive medication, above all levetiracetam monotherapy, in predicting the cognitive outcome of neurosurgical patients with post-traumatic brain injury, intracerebral haemorrhage and encephalic tumours.

Methods: We examined data concerning 232 out of 327 adult patients admitted to the Neurorehabilitation Department of the San Raffaele Hospital (Milan, Italy) after discharge from the Neurosurgery Department. Cognitive status was evaluated by means of the "Mini-Mental State" examination and the Functional Independence Measure at baseline and at the end of a rehabilitation care with an average duration of about four weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.03.243DOI Listing
April 2019
2 Reads

Mitochondrial metabolic stroke: Phenotype and genetics of stroke-like episodes.

Authors:
Josef Finsterer

J Neurol Sci 2019 May 23;400:135-141. Epub 2019 Mar 23.

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria. Electronic address:

Stroke-like episodes (SLEs) are the hallmark of mitochondrial encephalopathy with lactic acidosis and stroke-like episode (MELAS) syndrome but rarely occur also in other specific or nonspecific mitochondrial disorders. Pathophysiologically, SLLs are most likely due to a regional disruption of the blood-brain barrier triggered by the underlying metabolic defect, epileptic activity, drugs, or other factors. SLEs manifest clinically with a plethora of cerebral manifestations, which not only include features typically seen in ischemic stroke, but also headache, epilepsy, ataxia, visual impairment, vomiting, and psychiatric abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.03.021DOI Listing
May 2019
13 Reads

Assessment of Antiepileptic Drug Concentrations in HIV-Infected versus HIV-Negative Patients: A Retrospective Analysis.

Clin Pharmacokinet 2019 Apr 4. Epub 2019 Apr 4.

Gestione Ambulatoriale Politerapie (GAP) Outpatient Clinic, ASST Fatebenefratelli Sacco, Milan, Italy.

Introduction: A higher rate of subtherapeutic psychotropic drug concentrations was recently found in HIV-infected versus HIV-negative patients. In this study, we sought to investigate if this trend could also apply to antiepileptic drugs.

Methods: Overall, 700 HIV-infected patients were screened during the first 2 years after the introduction of our outpatient polytherapy management service (Gestione Ambulatoriale Politerapie [GAP]) in the search for subjects with antiepileptic drug trough concentration assessments. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40262-019-00752-6
Publisher Site
http://dx.doi.org/10.1007/s40262-019-00752-6DOI Listing
April 2019
1 Read

Episodes of prolonged "trance-like state" in an infant with hypothalamic hamartoma.

Ann Pediatr Endocrinol Metab 2019 Mar 31;24(1):55-59. Epub 2019 Mar 31.

Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Hypothalamic hamartoma (HH) is one of the most common causes of central precocious puberty (CPP) in first few years of life. It can present with either seizures or CPP, although both manifestations coexist in the majority of the children. Gelastic seizures (GS), or laughing spells, are usually the first type of seizures seen in patients with HH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6065/apem.2019.24.1.55DOI Listing
March 2019
1 Read

Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis.

J Vet Intern Med 2019 Apr 3. Epub 2019 Apr 3.

Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Science, Aichi, Japan.

A 7-year-old neutered female domestic shorthaired cat born in Poland and then moved to Japan presented to the local clinic with recent onset of convulsive cluster seizures and status epilepticus. Magnetic resonance imaging revealed bilateral swelling of the hippocampus with T2 hyperintensity and contrast enhancing image, suggesting hippocampal necrosis. The cat completely recovered after treatment with antiepileptic drugs (AED) and administration of prednisolone (1 mg/kg PO q24h for 4 days and tapered). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvim.15492DOI Listing
April 2019
1 Read

Differential effects of antiepileptic drugs on human bone cells.

J Cell Physiol 2019 Apr 2. Epub 2019 Apr 2.

Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, U. Porto, Portugal.

Antiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28569DOI Listing
April 2019
1 Read