Search our Database of Scientific Publications and Authors

I’m looking for a

    20412 results match your criteria Anticancer research[Journal]

    1 OF 409

    Phase II Trial of Carboplatin and Pemetrexed Plus Bevacizumab with Maintenance Bevacizumab as a First-line Treatment for Advanced Non-squamous Non-small Cell Lung Cancer in Elderly Patients.
    Anticancer Res 2018 Jun;38(6):3779-3784
    Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
    Background/aim: The combination of platinum-doublet chemotherapy with bevacizumab has been established as a first-line treatment option in non-elderly patients with non-squamous (non-sq) non-small cell lung cancer (NSCLC). However, the safety and efficacy of this regimen have not yet been fully established in elderly patients.

    Patients And Methods: Chemo-naïve patients with non-sq NSCLC, aged ≥75 years, having a good performance status (Eastern Cooperative Oncology Group performance status 0-1) and adequate organ function were considered eligible. Read More

    Postoperative Management of Multiple Primary Cancers Associated with Non-small Cell Lung Cancer.
    Anticancer Res 2018 Jun;38(6):3773-3778
    Departement of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Background/aim: Modern treatment for primary cancers has improved survival. Therefore, increased numbers of patients with multiple primary cancers (MPC) associated with lung cancer may be expected. The aim of the present study was to report MPC associated with lung cancer and discuss patients' characteristics and postoperative management. Read More

    Safety of Laparoscopic Surgery for Colorectal Cancer in Patients with Severe Comorbidities.
    Anticancer Res 2018 Jun;38(6):3767-3772
    Department of Surgery, Yokohama City University, Yokohama, Japan.
    Background/aim: Previous studies have shown that laparoscopic colorectal cancer surgery is highly safe and effective compared to laparotomy. However, whether laparoscopic colorectal cancer surgery can be safely performed in patients with severe comorbidities remains unclear. The aim of this study was to evaluate the safety of laparoscopic colorectal cancer surgery in patients with severe comorbidities. Read More

    Vulvar Melanoma with Isolated Metastasis to the Extraocular Muscles: Case Report and Brief Literature Review.
    Anticancer Res 2018 Jun;38(6):3763-3766
    Department of Radiation Oncology, Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, NY, U.S.A.
    Background/aim: Orbital metastasis of systemic cancer is exceedingly rare. This is a case report of a patient treated for locally recurrent vulvar melanoma who later presented with unilateral proptosis and was found to have an isolated biopsy-proven extraocular muscle metastasis.

    Patients And Methods: A 94-year-old female with locally recurrent vulvar melanoma presented with eye discomfort and blurry vision. Read More

    Renal Cell Carcinoma, Unclassified with Medullary Phenotype and Synchronous Renal Clear Cell Carcinoma Present in a Patient with No Sickle Cell Trait/Disease: Diagnostic and Therapeutic Challenges.
    Anticancer Res 2018 Jun;38(6):3757-3761
    Department of Pathology and Immunology, School of Medicine, Washington University in Saint Louis, St. Louis, MO, U.S.A.
    Renal medullary carcinoma (RMC) is an aggressive high-grade renal cell carcinoma (RCC) associated almost exclusively with sickle cell trait or sickle cell disease. However, RCC with RMC features has rarely been reported in patients with no sickle cell trait or disease. Renal cell carcinoma unclassified with medullary phenotype (RCCU-MP) is a newly-coined term used by an international panel of experts to describe renal cell carcinoma showing morphologic and immunohistochemical features of renal medullary carcinoma in patients without sickle cell trait/disease. Read More

    An Instrument for Estimating the 6-Month Survival Probability After Whole-brain Irradiation Alone for Cerebral Metastases from Gynecological Cancer.
    Anticancer Res 2018 Jun;38(6):3753-3756
    Department of Radiation Oncology, University of Lübeck, Lübeck, Germany
    Background/aim: Patients with cerebral metastases from gynecological cancer who receive whole-brain irradiation (WBI) alone require personalized therapy. This study contributes to personalized care by creating an instrument to predict 6-month survival probability.

    Patients And Methods: In 49 patients, six pre-treatment variables, namely age, Eastern Cooperative Oncology Group performance score (ECOG-PS), primary tumor type, number of cerebral metastases, metastasis outside the brain, and interval between diagnosis of gynecological cancer and WBI, were analyzed for survival. Read More

    Clinical Relevance of Postoperative Neutrophil-Lymphocyte Ratio (NLR) to Recurrence After Adjuvant Chemotherapy of S-1 for Gastric Cancer.
    Anticancer Res 2018 Jun;38(6):3745-3751
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.
    Background/aim: The clinical significance of postoperative neutrophil lymphocyte ratio (NLR) remains unclear. The aim of this study was to examine the impact of postoperative NLR on prediction for postoperative recurrence of gastric cancer.

    Patients And Methods: A retrospective analysis was performed on data from 170 patients with Stage II/III gastric cancer who underwent surgery followed by adjuvant chemotherapy using S-1 between 2006 and 2015. Read More

    Epidemiological Characteristics, Status and Management Patterns of Advanced Non-small Cell Lung Cancer Patients: The Greek REASON Observational Registry Study.
    Anticancer Res 2018 Jun;38(6):3735-3744
    2nd Department of Medical Oncology, Metropolitan Hospital, Piraeus, Greece.
    Background/aim: Real-world evidence regarding the prevalence of epidermal growth factor receptor (EGFR) mutation-positive status (M+) and the clinicopathological characteristics associated with the presence of EGFR mutations in advanced non-small cell lung cancer (NSCLC) is scarce, especially among Caucasian populations. The present study aimed to bridge this gap, as well as to record treatment patterns and outcomes in routine-care settings.

    Patients And Methods: REASON (NCT01153399) was a prospective study of patients with stage IIIB/IV NSCLC and known EGFR mutation status. Read More

    Radiological Features of Brain Metastases from Non-small Cell Lung Cancer Harboring Mutation.
    Anticancer Res 2018 Jun;38(6):3731-3734
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Aim: To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).

    Patients And Methods: Thirty-four patients with NSCLC with BMs who underwent surgical resection of the BMs at the Department of Neurosurgery, Kyushu University from 2005 to 2016 were enrolled in the study. The EGFR statuses of the 34 BMs were investigated. Read More

    Percutaneous Endoscopic Gastrostomy Tube Is a Negative Prognostic Factor for Recurrent/Metastatic Head and Neck Cancer.
    Anticancer Res 2018 Jun;38(6):3725-3729
    Oncology Insitute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.
    Background/aim: Recurrent/metastatic head and neck squamous cell cancer (r/mHNSCC) patients often need a percutaneous endoscopic gastrostomy feeding tube (PEG). Among known prognostic factors, PEG could be prognostic as well.

    Patients And Methods: We retrospectively analyzed r/mHNSCC patients referred for systemic treatment. Read More

    Tumor Expression of and Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population.
    Anticancer Res 2018 Jun;38(6):3719-3724
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Background/aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Read More

    Abdominal Emergencies in Patients with Stage IV Melanoma: The Role of Surgery: A Single-centre Experience.
    Anticancer Res 2018 Jun;38(6):3713-3718
    First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
    Background/aim: Metastatic melanoma is an aggressive disease with poor prognosis. Melanoma can potentially involve any organ. In this article, we report on a single-centre experience in emergency surgery for M1c melanoma. Read More

    Prevalence of Enhancer of Zeste Homolog 2 in Patients with Resected Small Cell Lung Cancer.
    Anticancer Res 2018 Jun;38(6):3707-3711
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Background/aim: Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is deeply involved in cancer pathogenesis. Although clinicopathological significance of EZH2 in non-small cell lung cancer has been gradually elucidated, such significance in small cell lung cancer (SCLC) has yet to be fully investigated.

    Patients And Methods: Forty patients with resected SCLC were analyzed for EZH2. Read More

    Daily Setup Accuracy, Side-effects and Quality of Life During and After Prone Positioned Prostate Radiotherapy.
    Anticancer Res 2018 Jun;38(6):3699-3705
    Department of Oncotherapy, University of Szeged, Szeged, Hungary
    Background/aim: Exposure of organs at risk with prostate radiotherapy (RT) is lower in the prone position. This study is a prospective evaluation of setup accuracy, side-effects, and quality of life (QOL) during and after prone positioned RT.

    Patients And Methods: Image-guided (IG) intensity-modulated (IM) RT was administered in prone position on belly-board to 55 high-risk prostate cancer (PC) patients. Read More

    Oral Metronomic Vinorelbine in Advanced Non-small Cell Lung Cancer Patients Unfit for Chemotherapy.
    Anticancer Res 2018 Jun;38(6):3689-3697
    Department of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of Catania, Catania, Italy.
    Aim: To explore the feasibility and activity of oral metronomic vinorelbine patients with advanced NSCLC not eligible to standard chemotherapy because of old age (≥70 years), and/or poor Eastern Cooperative Oncology Group performance status (≥2), and/or extensive brain or bone disease, and/or active comorbidities (≥2) requiring for pharmacological treatment.

    Patients And Methods: In a prospective phase II not randomized study, patients with stage IV NSCLC unfit to chemotherapy were treated with oral metronomic vinorelbine at 30 mg fixed dose three times a week until disease progression.

    Results: Fifty patients were treated, 19 (38%) in the first-line setting. Read More

    Co-occurrence of p.Gly111fs and p.Arg16His Variants in Familial MEN1 Phenotype.
    Anticancer Res 2018 Jun;38(6):3683-3687
    Department of Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Background/aim: Familial multiple endocrine neoplasia type 1 (MEN1) is a rare disorder mostly associated with germline MEN1 mutations.

    Materials And Methods: Genotyping of the MEN1, cyclin-dependent kinase inhibitor 1B (CDKN1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes using Sanger sequencing was carried out in a family with MEN1 and the resulting germline variants genotyped in an additional 95 ethnically matched controls.

    Results: A missense variant in AIP (p. Read More

    Usefulness of Preoperative F-FDG-PET in Detecting Invasive Intraductal Papillary Neoplasm of the Bile Duct.
    Anticancer Res 2018 Jun;38(6):3677-3682
    Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
    Background/aim: Preoperative identification of the invasive component remains challenging in intraductal papillary neoplasm of the bile duct (IPNB). We evaluated the ability of preoperative F-fluorodeoxyglucose positron emission tomography (F-FDG-PET) to differentiate between non-invasive IPNB, invasive IPNB, and papillary cholangiocarcinoma (CCA).

    Patients And Methods: The maximum standardized uptake values (SUV) of 11 patients with IPNB (6 non-invasive and 5 invasive) and 20 with papillary CCA who underwent pre-surgical F-FDG-PET were assessed. Read More

    Malignant Transformation in Mature Cystic Teratomas of the Ovary: Case Reports and Review of the Literature.
    Anticancer Res 2018 Jun;38(6):3669-3675
    Department of New Technologies and Translational Research, Division of Pathology, University of Pisa, Pisa, Italy.
    Malignant transformation occurs in 1.5-2% of mature cystic teratomas (MCT)s of the ovary and usually consists of squamous cell carcinoma, whereas other malignancies are less common. Diagnosis and treatment represent a challenge for gynecologic oncologists. Read More

    The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression.
    Anticancer Res 2018 Jun;38(6):3663-3667
    Department of Molecular Medicine, Jessenius Faculty of Medicine in Martin, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia.
    Background/aim: Interleukin-6 is an important modulator of inflammation, which is one of the factors involved in prostate cancer. The aim of the study was to evaluate the possible association of the IL-6 -174 polymorphism (rs1800795) with the risk of prostate cancer development and progression.

    Materials And Methods: The study population consisted of 446 prostate cancer patients, 377 benign prostatic hyperplasia (BHP) patients and 276 healthy men. Read More

    Factors Predictive of Sentinel Lymph Node Involvement in Primary Breast Cancer.
    Anticancer Res 2018 Jun;38(6):3657-3662
    Department of Gynaecology and Obstetrics, Helios Hospital Krefeld, Krefeld, Germany.
    Background/aim: Sentinel lymph node biopsy (SLNB) has replaced axillary lymph node dissection (ALND) for axillary staging in patients with early-stage breast cancer. The need for therapeutic ALND is the subject of ongoing debate especially after the publication of the ACOSOG Z0011 trial. In a retrospective trial with univariate and multivariate analyses, factors predictive of sentinel lymph node involvement should be analyzed in order to define tumor characteristics of breast cancer patients, where SLNB should not be spared to receive important indicators for adjuvant treatment decisions (e. Read More

    Hyperfractionated or Accelerated Hyperfractionated Re-irradiation with ≥42 Gy in Combination with Paclitaxel for Secondary/Recurrent Head-and-Neck Cancer.
    Anticancer Res 2018 Jun;38(6):3653-3656
    Department of Oral and Maxillofacial Surgery, University of Lübeck, Lübeck, Germany.
    Background/aim: Patients with secondary/ recurrent squamous cell head and neck cancer (SCCHN) have poor prognoses. Outcomes of re-irradiation with ≥42 Gy plus paclitaxel for secondary/recurrent SCCHN are herein presented.

    Patients And Methods: Two patients re-irradiated for secondary/recurrent SCCHN were evaluated. Read More

    Perioperative Tumour Marker Levels as Prognostic Factors for Surgical Treatment of Breast Cancer Liver Metastases.
    Anticancer Res 2018 Jun;38(6):3647-3652
    Immunodiagnostic Department, University Hospital, Faculty of Medicine, Pilsen, Czech Republic.
    Background/aim: The results of surgical treatment of breast cancer liver metastases (BCLM) remain suboptimal. The search for perioperative prognostic factors could help determine high risk groups of patients. The aim of study was to evaluate the significance of tumour markers (TM) on long-term treatment results. Read More

    Fertility-sparing Surgery for Presumed Early-stage Invasive Cervical Cancer: A Survey of Practice in the United Kingdom.
    Anticancer Res 2018 Jun;38(6):3641-3646
    Institute of Reproductive and Developmental Biology, Surgery and Cancer, Imperial College London, London, U.K.
    Aim: To explore current practice in fertility-sparing surgery for cervical cancer in the UK.

    Materials And Methods: A web-based structured questionnaire was designed and circulated to all members of the British Gynaecological Cancer Society.

    Results: From 111 recipients, a total of 49 responses were collected. Read More

    Is FDG-PET/CT Useful for Diagnosing Pulmonary Metastasis in Patients with Soft Tissue Sarcoma?
    Anticancer Res 2018 Jun;38(6):3635-3639
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
    Background/aim: In patients with soft tissue sarcoma (STS), distinguishing small metastatic pulmonary nodules from benign ones remains difficult. This study aimed to determine the accuracy of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting pulmonary metastasis and identify factors affecting sensitivity with STS.

    Materials And Methods: The clinical records and chest CT and FDG-PET/CT scans of 102 patients with STS were reviewed to determine the presence of pulmonary nodules. Read More

    Neoadjuvant Platinum-based Chemotherapy Followed by Radical Hysterectomy for Stage Ib2-IIb Adenocarcinoma of the Uterine Cervix - An Italian Multicenter Retrospective Study.
    Anticancer Res 2018 Jun;38(6):3627-3634
    Department of Gynecology and Obstetrics, University of Brescia, Brescia, Italy.
    Aim: To assess the patterns of recurrence and clinical outcomes of patients with cervical adenocarcinoma who underwent neoadjuvant platinum-based chemotherapy (NACT) followed by radical hysterectomy.

    Patients And Methods: Data were retrospectively analyzed for 82 patients with International Federation of Gynecology and Obstetrics stage Ib2-IIb cervical adenocarcinoma who underwent this chemo-surgical treatment. The median follow-up of survivors was 89 months (range=5-208 months). Read More

    The Role of PAR1 Autoantibodies in Patients with Primary Epithelial Ovarian Cancer.
    Anticancer Res 2018 Jun;38(6):3619-3625
    Department of Gynecology, Charitè University Berlin, Berlin, Germany.
    Aim: This study aimed to analyze the predictive, prognostic and diagnostic value of autoantibodies to coagulation factor II thrombin receptor (F2R; protease-activated receptor 1, PAR1) (PAR1-AB) in patients with primary epithelial ovarian cancer (EOC).

    Materials And Methods: A total of 197 patients with primary EOC and 200 healthy female blood donors were included in the study. Enzyme-linked immunosorbent assay was applied to determine PAR1-AB levels in blood sera taken preoperatively. Read More

    Oncologic Effectiveness and Safety of Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: Meta-analysis of Randomized Controlled Trials.
    Anticancer Res 2018 Jun;38(6):3609-3617
    General Surgery, Department of Surgery, San Giovanni Battista Hospital-AUSL Umbria 2, Foligno, Italy.
    Background/aim: The role of splenectomy as an essential component of radical surgery for proximal gastric cancer, from an oncological point of view, is still debated, and no consistent recommendations have been proposed. The aim of this systematic review with meta-analysis was to provide a more robust answer regarding the oncological effectiveness and safety of splenectomy in total gastrectomy for proximal gastric carcinoma.

    Materials And Methods: A systematic review and meta-analysis of randomized controlled trials was planned and performed in accordance with Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and Cochrane Handbook for Systematic Reviews of Intervention. Read More

    Altered Polyamine Profiles in Colorectal Cancer.
    Anticancer Res 2018 Jun;38(6):3601-3607
    Department of Surgery, School of Medicine, University of Eastern Finland, Kuopio, Finland
    Background: The declining mortality rate of patients with colorectal cancer (CRC) can be explained, at least partially, with early diagnosis. Simple diagnostic methods are needed to achieve a maximal patient participation rate in screening.

    Materials And Methods: Liquid chromatography electrospray tandem mass spectrometry (LC-MS/MS) was used to determine urinary polyamine (PA) profiles. Read More

    Significance of Age in Japanese Patients Receiving Sunitinib as First-line Systemic Therapy for Metastatic Renal Cell Carcinoma: Comparative Assessment of Efficacy and Safety between Patients Aged <75 and ≥75 Years.
    Anticancer Res 2018 Jun;38(6):3593-3599
    Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background/aim: To date, it has not been well characterized whether sunitinib is effective in elderly patients with metastatic renal cell carcinoma (mRCC). The objective of this study was to investigate the impact of age on clinical outcomes of mRCC patients receiving sunitinib.

    Patients And Methods: The efficacy and safety of first-line sunitinib in 154 consecutive mRCC patients were retrospectively compared between patients aged <75 (n=125) and ≥75 (n=29) years. Read More

    Feasibility and Safety of CT-guided Intrathoracic and Bone Re-biopsy for Non-small Cell Lung Cancer.
    Anticancer Res 2018 Jun;38(6):3587-3592
    Department of Radiology, Tokai University Hachioji Hospital, Tokai University School of Medicine, Tokyo, Japan
    Aim: This study aimed to retrospectively determine the feasibility and safety of computed tomography (CT)-guided intrathoracic and bone re-biopsy for patients with non-small cell lung cancer (NSCLC).

    Materials And Methods: Seventeen patients underwent CT-guided intrathoracic or bone re-biopsy for the determination of epidermal growth factor receptor (EGFR) T790M mutation and/or programmed cell death-ligand 1 (PD-L1) expression. The characteristics of each lesion, success rate of analyses, and complications were investigated. Read More

    No Deterioration in Clinical Outcomes of Carbon Ion Radiotherapy for Sarcopenia Patients with Hepatocellular Carcinoma.
    Anticancer Res 2018 Jun;38(6):3579-3586
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan.
    Background/aim: The relationship between sarcopenia and prognosis in carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) has not yet been reported, therefore we analyzed the presence or absence of sarcopenia before C-ion RT as a prognostic factor for patients with HCC.

    Patients And Methods: Data were retrospectively collected for patients who had undergone C-ion RT for HCC between September 2010 and December 2016. For defining the presence or absence of sarcopenia, skeletal muscles in the third lumbar vertebrae level were measured. Read More

    Gallstone Patients with Enhanced Oxidative Stress Biomarker Superoxide Dismutase (SOD1) Plasma Levels Have Significantly Lower Number of Postoperative Analgesic Oxycodone Doses: A Prospective Study with Special Reference to Cancer Patients.
    Anticancer Res 2018 Jun;38(6):3573-3578
    Department of Surgery, Kuopio University Hospital, Kuopio, Finland
    Background/aim: Oxidative stress biomarker superoxide dismutase (SOD1) plasma levels in operated gallstone patients versus cancer patients are unknown. In addition, the number of analgesic doses during the first 24 h postoperatively (NAD) in gallstone patients operated with laparoscopic cholecystectomy (LC) or minicholecystectomy (MC) is unreported. The aim of the study was to determine a correlation between the plasma SOD1 levels in the LC and MC patients versus cancer patients. Read More

    Impact of Pleural Effusion on Outcomes of Patients Receiving Osimertinib for NSCLC Harboring T790M.
    Anticancer Res 2018 Jun;38(6):3567-3571
    Department of Thoracic Oncology, Osaka Habikino Medical Center, Habikino, Japan.
    Background/aim: Osimertinib has demonstrated promising efficacy in patients with epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC). We investigated the efficacy of osimertinib in such patients presenting with pleural effusion, which has been unclear to date.

    Patients And Methods: The medical records of all patients treated with osimertinib for advanced NSCLC with EGFR T790M between April 2016 and July 2017 at our Institution were retrospectively reviewed. Read More

    Current Status and Problems of T790M Detection, a Molecular Biomarker of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors, with Liquid Biopsy and Re-biopsy.
    Anticancer Res 2018 Jun;38(6):3559-3566
    Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Background/aim: The purpose of this study was to consider appropriate application of liquid and re-biopsy through analysis of current status in practice.

    Patients And Methods: We performed a retrospective analysis of 22 patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer who exhibited 1st/2nd generation EGFR-tyrosine kinase inhibitors resistance. The cobas® method was used to detect T790M with re-biopsy and the mutation-biased PCR and quenched probe method was used with liquid biopsy. Read More

    Stromal p16 Overexpression in Gastric-type Mucinous Carcinoma of the Uterine Cervix.
    Anticancer Res 2018 Jun;38(6):3551-3558
    Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    Background/aim: Gastric-type mucinous carcinoma (MC-G) of the uterine cervix displays distinct morphological features and an aggressive clinical course. The expression status of p16 in the stroma has not been investigated in adenocarcinoma of the uterine cervix. Stromal p16 expression was evaluated in endocervical adenocarcinomas, including usual-type endocervical adenocarcinoma (UEA), intestinal-type mucinous carcinoma (MC-I), and MC-G. Read More

    Definitive Chemoradiation in Locally Advanced Squamous Cell Carcinoma of the Hypopharynx: Long-term Outcomes and Toxicity.
    Anticancer Res 2018 Jun;38(6):3543-3549
    Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, U.S.A.
    Background/aim: Definitive chemoradiation (CRT) is a common approach for locally advanced hypopharyngeal squamous cell carcinoma (SCC) with the goal of organ preservation. Reports on long-term oncologic and functional outcomes have been limited. This study reports on outcomes utilizing this approach at a single institution over 30 years. Read More

    Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma.
    Anticancer Res 2018 Jun;38(6):3535-3542
    Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA, U.S.A.
    Background: Well-differentiated/dedifferentiated (WD/DD) liposarcoma is a rare malignancy of putative adipocyte origin. To our knowledge, there have only been isolated case reports describing second primary cancer in patients with this disease. We report on a combined case series of such patients and explore the frequency of this occurrence using a national cancer database. Read More

    Fisetin Enhances the Cytotoxicity of Gemcitabine by Down-regulating ERK-MYC in MiaPaca-2 Human Pancreatic Cancer Cells.
    Anticancer Res 2018 Jun;38(6):3527-3533
    Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Background: Pancreatic cancer is a highly lethal malignancy with a poor prognosis. This study was set up to investigate the combined effect of gemcitabine and fisetin, a natural flavonoid from plants, on human pancreatic cancer cells. Meterials and Methods: Cytotoxic effect of fisetin in combination with gemcitabine on MiaPaca-2 cells was evaluated by the MTT assay, caspase 3/7 assay and propidium iodide/Annexin V. Read More

    Enigma Plays Roles in Survival of Thyroid Carcinoma Cells through PI3K/AKT Signaling and Survivin.
    Anticancer Res 2018 Jun;38(6):3515-3525
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Republic of Korea
    Background/aim: The aim of the present study was to assess the role of enigma protein in survival of thyroid carcinoma cells.

    Materials And Methods: BCPAP and 8505C human thyroid carcinoma cells were used. Cell viability using CCK-8 assay, the percentage of dead cells using trypan blue assay, cytotoxic activity using cytotoxicity assay, cell growth rate and cell migration using wound-healing assay were performed. Read More

    Knockdown of 14-3-3γ Suppresses Epithelial-Mesenchymal Transition and Reduces Metastatic Potential of Human Non-small Cell Lung Cancer Cells.
    Anticancer Res 2018 Jun;38(6):3507-3514
    Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
    Background/aim: 14-3-3γ is involved in the metastasis of lung cancer cells. However, its functional roles in tumor cell invasion and the underlying mechanisms are still not understood. In this study, the roles and molecular mechanisms of 14-3-3γ in epithelial-mesenchymal transition (EMT), migration, and invasion were investigated using A549 and H358 non-small cell lung cancer (NSCLC) cell lines. Read More

    Cystathionine Promotes the Proliferation of Human Astrocytoma U373 Cells.
    Anticancer Res 2018 Jun;38(6):3501-3505
    Chair of Medical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
    Background/aim: In certain cancers, accumulation of cystathionine has been observed. The present study investigated the effect of cystathionine on astrocytoma (U373) cell proliferation, the activity of γ-cystathionase (CTH) and changes in thiols levels.

    Materials And Methods: The methods used in the study included cytotoxicity assay, crystal violet staining method, CTH activity assay and reverse phase-high performance liquid chromatography (RP-HPLC). Read More

    Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells.
    Anticancer Res 2018 Jun;38(6):3493-3500
    Department of Urology, National Defense Medical College, Tokorozawa, Japan.
    Background/aim: To investigate the efficacy against renal cancer cells of combining the HIV protease inhibitor ritonavir with the novel proteasome inhibitor delanzomib.

    Materials And Methods: Renal cancer cell lines 769-P, 786-O, Caki-2 and Renca were treated with ritonavir and delanzomib in vitro and in vivo, and the efficacy of combination was evaluated.

    Results: The combination of ritonavir and delanzomib synergistically inhibited renal cancer growth and suppressed colony formation. Read More

    Exploring the Role of Enzalutamide in Combination with Radiation Therapy: An Study.
    Anticancer Res 2018 Jun;38(6):3487-3492
    Department of Molecular and Translational Medicine, Unit of Biotechnology, University of Brescia, Brescia, Italy.
    Background/aim: Androgen receptor plays a key role in prostate cancer development and is a causative agent of its radio-resistance. The present study investigated the potential radio-sensitizing effect of enzalutamide, a second-generation anti-androgen, in human prostate cancer cells.

    Materials And Methods: The radio-sensitizing effect of enzalutamide was assessed in the androgen-dependent LNCaP cells and the androgen-independent PC3 cells by clonogenic assay and γ-H2AX assay. Read More

    MicroRNA-203 Induces Apoptosis by Targeting in YD-38 Oral Cancer Cells.
    Anticancer Res 2018 Jun;38(6):3477-3485
    Oral Biology Research Institute, School of Dentistry, Chosun University, Gwangju, Republic of Korea
    Background/aim: MicroRNAs (miRNAs) are closely associated with a number of cellular processes, including cell development, differentiation, proliferation, carcinogenesis, and apoptosis. The aim of the present study was to elucidate the molecular mechanisms underlying the tumor suppressor activity of miRNA-203 (miR-203) in YD-38 human oral cancer cells.

    Materials And Methods: Polymerase chain reaction analysis, MTT assay, DNA fragmentation assay, fluorescence-activated cell-sorting analysis, gene array, immunoblotting, and luciferase assay were carried out in YD-38 cells. Read More

    Sensitisation of Cancer Cells to MLN8237, an Aurora-A Inhibitor, by YAP/TAZ Inactivation.
    Anticancer Res 2018 Jun;38(6):3471-3476
    Department of Integrated Information for Pharmaceutical Sciences, Iwate Medical University School of Pharmacy, Morioka, Japan.
    Background: Transcriptional co-activators YES-associated protein (YAP) and transcriptional coactivator with PDZ-motif (TAZ) stimulate the expression of cell cycle-related genes to permit for tumour cell growth. MLN8237 is a potent aurora-A kinase inhibitor; however, patients responding to MLN8237 are limited. Therefore, rational combination therapy could enhance their response. Read More

    A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice.
    Anticancer Res 2018 Jun;38(6):3467-3470
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
    Background/aim: Our aim was to develop an animal model of the precancerous stages of colitis-associated carcinogenesis by modifying the established azoxymethane/dextran sulfate sodium (AOM/DSS) protocol.

    Materials And Methods: Six mice were treated with varying cycles of DSS following AOM administration as above (group 1: three mice received three 5-day cycles of 3.0% DSS and group 2: three mice received three 7-day cycles of 2. Read More

    Ampakines Attenuate Staurosporine-induced Cell Death in Primary Cortical Neurons: Implications in the 'Chemo-Brain' Phenomenon.
    Anticancer Res 2018 Jun;38(6):3461-3465
    RespireRx Pharmaceuticals, Inc., Glen Rock, NJ, U.S.A.
    Background/aim: Mounting evidence suggests that trophic cell signaling can be mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) activation. It has been demonstrated that exogenous application of brain-derived neurotrophic factor (BDNF) is highly neuroprotective in vitro against neurotoxic insults such as standard chemotherapies.

    Materials And Methods: Because positive allosteric modulation of AMPARs with ampakines can increase both BDNF mRNA and protein in vitro and in vivo, we examined whether application of the ampakines CX614 and CX729 promoted neuroprotection against staurosporine-induced cell death in rat primary cortical neurons using propidium iodide to stain for dead cells. Read More

    Differential Expression of IGF-I Transcripts in Bladder Cancer.
    Anticancer Res 2018 Jun;38(6):3453-3459
    Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Background/aim: A growing body of evidence shows that the differential expression of E domain-related insulin-like growth factor-I (IGF-I) transcripts (IFG-IEa, IGF-IEb and IGF-IEc) in normal and cancerous tissues, implicating specific biological roles for the putative Ea, Eb, and Ec peptides, beyond IGF-I. Herein, we investigated the expression profile of IGF-IEa, IGF-IEb and IGF-IEc transcripts in bladder cancer and compared them with samples from the normal adjacent bladder tissue.

    Materials And Methods: Biopsies from 46 patients (39 men and 7 women), aged 73. Read More

    Pressurized Intra-peritoneal Aerosol Chemotherapy (PIPAC) Endoscopical Microcatheter System.
    Anticancer Res 2018 Jun;38(6):3447-3452
    Division of Colorectal Surgery, Department of Surgery, University of California, Irvine, CA, U.S.A.
    Background/aim: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is becoming an increasingly widespread approach for delivering intra-peritoneal chemotherapy (IPC) by means of a chemoaerosol. Currently, the aerosol dispersion is achieved by using a special micropump (MIP®). However, the delivery of a chemoaerosol into the abdominal cavity is not limited to the MIP®. Read More

    1 OF 409