21,093 results match your criteria Anticancer research[Journal]


Five-year Recurrence-free Survival After Surgery Followed by Oral Chemotherapy for Gastric Cancer With Portal Vein Tumor Thrombosis.

Anticancer Res 2019 Apr;39(4):2233-2238

Department of Surgery, Kumamoto Chuo hospital, Kumamoto, Japan.

Gastric cancer with portal vein tumor thrombosis (GC-PVTT) is a rare condition with a very poor prognosis. A 64-year-old man with GC-PVTT was admitted to our hospital. His carcinoembryonic antigen level was slightly elevated (17. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13339DOI Listing
April 2019
3 Reads

Enteral Access Potentially Endangers Esophageal Carcinoma Patients Under Multi-modality Therapy: A Population-based Study.

Anticancer Res 2019 Apr;39(4):2227-2232

Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan, R.O.C.

Background/aim: This study aimed to evaluate the clinical outcome of esophageal cancer (EC) patients with enteral access (EA) undergoing multimodality therapy.

Patients And Methods: This retrospective study analyzed data between 1997 and 2012 in Taiwan using the National Health Insurance Research Database. Patients with newly-diagnosed EC undergoing multimodality therapy were identified and classified as either EA group or no-EA group. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13338DOI Listing
April 2019
8 Reads

Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma.

Anticancer Res 2019 Apr;39(4):2217-2226

Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea

Background/aim: Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC).

Materials And Methods: We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) carriers without HCC.

Results: Kaplan-Meier analysis showed that patients with the FGF2 rs308447 TT genotype had shorter overall survival than patients with the CC or CT genotype (p=0. Read More

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http://dx.doi.org/10.21873/anticanres.13337DOI Listing
April 2019
2 Reads
1.872 Impact Factor

Local Control and Clinical Outcome of High-risk Pediatric Neuroblastoma Patients After Receiving Multimodality Treatment and Helical Tomotherapy.

Anticancer Res 2019 Apr;39(4):2207-2215

Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, R.O.C.

Background/aim: The local control and clinical outcome of pediatric patients with high-risk neuroblastoma treated with tomotherapy as part of a modern multimodality paradigm was assessed.

Patients And Methods: Twenty-four high-risk neuroblastoma patients who received radiotherapy (RT) to the primary site using helical tomotherapy (median 21.6 Gy) were included. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13336DOI Listing
April 2019
2 Reads

Risk Factors for Life-threatening Grade C Postoperative Pancreatic Fistula After Pancreatoduodenectomy Compared to Grade B.

Anticancer Res 2019 Apr;39(4):2199-2205

Department of Digestive and Transplantation Surgery, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.

Background: The aim of the present study was to investigate risk factors for the development of grade C compared to grade B cases of postoperative pancreatic fistula (POPF).

Materials And Methods: Clinicopathological data from 43 patients who developed grade B or C POPF were retrospectively analyzed. The following types of factors were analyzed: Patient-related, surgery-related, and pancreas-related, including the value of the drain amylase and the detection of gram-negative rod bacteria within the first 7 postoperative days (PODs). Read More

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http://dx.doi.org/10.21873/anticanres.13335DOI Listing

Postoperative C-reactive Protein Is a Predictive Biomarker for Survival After Non-small Cell Lung Cancer Resection.

Anticancer Res 2019 Apr;39(4):2193-2198

Department of Thoracic Surgery, Chubu Rosai Hospital, Nagoya, Japan.

Background/aim: Preoperative C-reactive protein (CRP) is well recognized as a prognostic factor of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the prognostic impact of postoperative CRP in patients with NSCLC following lung resection.

Patients And Methods: We retrospectively reviewed 336 patients with NSCLC treated with lung resection. Read More

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http://dx.doi.org/10.21873/anticanres.13334DOI Listing
April 2019
1 Read

Influence of Sorafenib on Host Immunity in Patients with Liver Cirrhosis With Advanced Hepatocellular Carcinoma Stratified by Etiology.

Anticancer Res 2019 Apr;39(4):2183-2191

Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.

Aim: We previously reported that sorafenib induces Th1 [interferon-γ (IFNγ)-positive interleukin 4 (IL4)-negative] dominance which prevents tumor cells from escaping the host immune system in patients with liver cirrhosis (LC) and advanced hepatocellular carcinoma (aHCC). However, in that study we did not assess the influence of sorafenib on host immunity according to the etiology of LC. Therefore, this study was retrospectively performed to evaluate the impact of sorafenib therapy for aHCC on host immunity in patients stratified according to the etiology of LC: Patients and Methods: A total of 116 adult Japanese patients with LC and aHCC received sorafenib therapy at our hospital. Read More

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http://dx.doi.org/10.21873/anticanres.13333DOI Listing
April 2019
1 Read

Association of Statin Use and Oncological Outcomes After Neoadjuvant Radiotherapy in Patients With Rectal Cancer.

Anticancer Res 2019 Apr;39(4):2177-2182

Department of Surgery, Zealand University Hospital, Køge, Denmark.

Aim: The aim of the study was to examine if statin exposure during neoadjuvant chemoradiotherapy improves oncological outcomes in patients with rectal cancer.

Patients And Methods: The study cohort consisted of patients who were undergoing neoadjuvant chemoradiotherapy and resection for rectal cancer. The statin users were matched 1:1 with non-users using propensity score-based matching. Read More

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http://dx.doi.org/10.21873/anticanres.13332DOI Listing
April 2019
2 Reads

Lymphocyte-to-Monocyte Ratio and Prognostic Nutritional Index Predict Poor Prognosis in Patients on Chemotherapy for Unresectable Pancreatic Cancer.

Anticancer Res 2019 Apr;39(4):2169-2176

Department of General and Gastroenterological Surgery, Osaka Medical College, Osaka, Japan.

Background/aim: Recently, several systemic inflammation-based scores, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), modified Glasgow prognostic score (GPS), and prognostic nutritional index (PNI), have been proposed as prognostic factors for several cancers. In this study, we aimed to determine the influence of systemic inflammation-based scores and nutrition status on the outcome in patients receiving chemotherapy for unresectable pancreatic cancer.

Patients And Methods: A total of 93 consecutive patients who underwent chemotherapy for unresectable pancreatic cancer at Osaka Medical College Hospital, Takatsuki, Japan, between January 2008 and December 2014 were eligible for this study. Read More

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http://dx.doi.org/10.21873/anticanres.13331DOI Listing
April 2019
1 Read

Myelosuppression After Radiation Therapy in Patients With and Without Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Observational Study.

Anticancer Res 2019 Apr;39(4):2163-2167

Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.

Background/aim: Autologous hematopoietic stem cell transplantation (ASCT) after high-dose chemotherapy is used to treat relapsed malignant lymphomas. Radiation therapy (RT) is applied after ASCT. We compared the incidence of myelosuppression after RT with and without autologous peripheral blood stem cell transplantation (auto-PBSCT). Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13330DOI Listing
April 2019
16 Reads

The Efficacy and Limitations of Postoperative Adjuvant Chemotherapy in Patients With Extrahepatic Cholangiocarcinoma.

Anticancer Res 2019 Apr;39(4):2155-2161

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/aim: The impact of adjuvant chemotherapy (AC) for extrahepatic cholangiocarcinoma (ECC) remains unclear. This study evaluated the efficacy and limitations of AC.

Patients And Methods: Between 2006 and 2016, 106 patients with stage II-IV ECC who underwent curative resection with biliary tract reconstruction were retrospectively analyzed. Read More

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http://dx.doi.org/10.21873/anticanres.13329DOI Listing
April 2019
1 Read

Exon 9 Mutation of Associated With Poor Survival in Patients With Epstein-Barr Virus-associated Gastric Cancer.

Anticancer Res 2019 Apr;39(4):2145-2154

Department of Hematology/Oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

Background: Epstein-Barr virus (EBV)-associated gastric cancer (GC) is known to harbor a significant enrichment of of phosphatidylinositol 4, 5-biphosphate 3- kinase catalytic subunit alpha isoform (PIK3CA). Therefore, this study investigated the clinical relevance and prognostic role of PIK3CA mutations in patients with EBV-GC.

Materials And Methods: After reviewing 1,318 consecutive cases of surgically resected GC, 120 patients were identified as EBV-positive using EBV-encoded RNA in situ hybridization. Read More

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http://dx.doi.org/10.21873/anticanres.13328DOI Listing
April 2019
1 Read

A 12-year Recurrence-free Survival After Multidisciplinary Treatment for a Patient With Combined Hepatocellular-Cholangiocarcinoma.

Anticancer Res 2019 Apr;39(4):2139-2144

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

We report a 64-year-old woman with a 9-cm liver tumor in the left lateral section. The patient had neither hepatitis B or C virus infection, nor cirrhosis. Carbohydrate antigen 19-9 (CA 19-9) level was 1,889 U/ml. Read More

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http://dx.doi.org/10.21873/anticanres.13327DOI Listing
April 2019
2 Reads

Association of Notch and Hedgehog Pathway Activation With Prognosis in Early-stage Colorectal Cancer.

Anticancer Res 2019 Apr;39(4):2129-2138

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece

Background/aim: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) are considered one of the reasons for treatment failure. Read More

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http://dx.doi.org/10.21873/anticanres.13326DOI Listing

Comparison of the Clinicopathological Features in Small Bile Duct and Bile Ductular Type Intrahepatic Cholangiocarcinoma.

Anticancer Res 2019 Apr;39(4):2121-2127

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Background: The classification of intrahepatic cholangiocarcinomas (ICCs) has been reported in several studies, however, it remains controversial.

Materials And Methods: Between January 2003 and December 2015, 94 patients underwent hepatectomy for ICC. The ICCs of 63 of these patients were classified as predominantly small bile duct type or bile ductular type ICC and were included in this analysis. Read More

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http://dx.doi.org/10.21873/anticanres.13325DOI Listing
April 2019
2 Reads

Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy.

Anticancer Res 2019 Apr;39(4):2113-2120

Unit of Digestive, Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France

Background/aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.

Patients And Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson test, and univariate and multivariate analysis. Read More

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http://dx.doi.org/10.21873/anticanres.13324DOI Listing
April 2019
1 Read

Dermatofibrosarcoma Protuberans on Adult Toes: A Case Report and Review of the Literature.

Anticancer Res 2019 Apr;39(4):2105-2111

Laboratory of Pathology, Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-grade, dermal soft-tissue neoplasm with high recurrence, but low metastatic potential. It mainly occurs on the trunk, proximal extremity, head and neck, but rarely on the toes. Herein we report a case of DFSP on the right hallux. Read More

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http://dx.doi.org/10.21873/anticanres.13323DOI Listing
April 2019
1 Read

Changes in Hyoid Bone Position and Cross-sectional Area of Pharyngeal Airway After Oral Cancer Surgery.

Anticancer Res 2019 Apr;39(4):2097-2104

Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea

Aim: To investigate hyoid bone position and cross-sectional area (CSA) of pharyngeal airway space (PAS) for assessing postoperative airway change after oral cancer surgery with concurrent neck dissection (ND).

Patients And Methods: Fifty-two patients who underwent oral cancer surgery with concurrent ND were retrospectively evaluated by grouping based on ND type and reconstruction. Computed tomographic data were analyzed three-dimensionally before and after surgery. Read More

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http://dx.doi.org/10.21873/anticanres.13322DOI Listing
April 2019
1 Read

Estimating Survival of Patients With Metastatic Renal Cell Carcinoma Receiving Whole-brain Radiotherapy With a New Tool.

Anticancer Res 2019 Apr;39(4):2091-2095

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Background/aim: A new tool for estimating survival of patients receiving whole-brain radiotherapy (WBRT) for intracerebral metastases from renal cell carcinoma (RCC) was created.

Patients And Methods: The new WBRT-30-RCC was developed in 34 patients homogeneously treated with 30 Gy in 10 fractions of WBRT and compared to updated diagnosis-specific graded prognostic assessment DS-GPA and Dziggel score for predicting death within 6 months and survival for at least 6 months following WBRT.

Results: WBRT-30-RCC included three groups with 6-month survival rates of 6. Read More

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http://dx.doi.org/10.21873/anticanres.13321DOI Listing
April 2019
3 Reads

Zone Formation of Lymphocyte Infiltration at the Invasive Front Results in the Prolonged Survival of Individuals With Endometrial Serous Carcinoma and Endometrioid Carcinoma With Serous Component.

Anticancer Res 2019 Apr;39(4):2085-2089

Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Japan.

Background/aim: This study aimed to evaluate the clinical significance of lymphocyte infiltration (LI) for patients with endometrial serous carcinoma and those with endometrioid carcinoma including serous component.

Patients And Methods: Patients who underwent surgery at our hospital between 1990 and 2013 were identified. LI was classified into strong LI, defined as a continuous thick zone of LI, and weak LI, defined as the lack of zone or scattered small foci of LI at the invasive front. Read More

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http://dx.doi.org/10.21873/anticanres.13320DOI Listing
April 2019
2 Reads

Assessing the Interleukin 35 Immunoexpression in Malignant Canine Mammary Tumors: Association With Clinicopathological Parameters and Prognosis.

Anticancer Res 2019 Apr;39(4):2077-2083

Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal

Background/aim: IL-35 has a prominent immunosuppressive role and its overexpression has been reported in human breast cancer. However, the impact of IL-35 in canine mammary carcinogenesis has not been addressed yet. The present study determined the clinicopathological significance of IL-35 immunoexpression and its correlation with overall survival (OS) in 72 malignant canine mammary tumor (CMT) patients. Read More

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http://dx.doi.org/10.21873/anticanres.13319DOI Listing
April 2019
1 Read

Diagnosis of Lymph Node Metastasis in Colorectal Cancer by a Semi-dry Dot-blot Method.

Anticancer Res 2019 Apr;39(4):2069-2076

Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan

Background/aim: This study aimed to examine whether the semi-dry dot-blot (SDB) method can correctly identify metastasis to lymph nodes in colorectal cancer.

Materials And Methods: A total of 200 dissected lymph nodes from 83 patients with colorectal cancer who underwent surgery between November 2013 and May 2016 were examined. Each lymph node was first examined by SDB using anti-pancytokeratin antibody (AE1/AE3). Read More

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http://dx.doi.org/10.21873/anticanres.13318DOI Listing
April 2019
1 Read

Evaluation of Follow-up Examinations Using Ultrasonography for Patients With Thyroid Nodules Initially Diagnosed as Benign.

Anticancer Res 2019 Apr;39(4):2061-2067

Department of Surgery, Kochi Medical School, Kochi, Japan.

Background/aim: The aim of this study was to determine the natural history of benign thyroid nodules using ultrasonography.

Patients And Methods: The records of 223 patients with benign thyroid nodules treated at the Kochi Medical School from 2010 to 2012 were reviewed retrospectively. Repeated ultrasonography was performed, and the findings were directly compared with previous images. Read More

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http://dx.doi.org/10.21873/anticanres.13317DOI Listing
April 2019
3 Reads

Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Trastuzumab Followed by 5-Fluorouracil/Epirubicin/Cyclophosphamide for HER2-positive Operable Breast Cancer: A Multicenter Phase II Trial.

Anticancer Res 2019 Apr;39(4):2053-2059

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Aim: This study was conducted in order to evaluate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus trastuzumab followed by 5-fluorouracil/ epirubicin/cyclophosphamide (FEC) in a neoadjuvant chemotherapy (NAC) setting for patients with human epidermal growth factor receptor 2 (HER2)-positive operable breast cancer.

Patients And Methods: Each patient received four cycles of 260 mg/m nab-paclitaxel with 6 mg/kg trastuzumab (8 mg/kg as the loading dose) every 3 weeks (q3w) followed by four cycles of FEC (500/100/500 mg/m) q3w. The primary endpoint was pathological complete response (pCR) rate. Read More

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http://dx.doi.org/10.21873/anticanres.13316DOI Listing
April 2019
1 Read

Immune Phenotype Correlates With Survival in Patients With GBM Treated With Standard Temozolomide-based Therapy and Immunotherapy.

Anticancer Res 2019 Apr;39(4):2043-2051

Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.

Background/aim: The need for more effective treatment modalities that can improve the clinical outcome of patients with glioblastoma multiforme remains imperative. Dendritic cell vaccination is a fast-developing treatment modality, currently under exploration. Functional immune cell subpopulations may play a role in the final outcome. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13315DOI Listing
April 2019
5 Reads

Towards a Personalized Approach in Pancreatic Cancer Diagnostics Through Plasma Amino Acid Analysis.

Anticancer Res 2019 Apr;39(4):2035-2042

Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Background/aim: Body fluid biomarkers may provide means for early pancreatic cancer diagnosis, patient stratification, application of personalized approaches and, finally, improved outcomes. Amino acids are the most frequently distinguished metabolite class in the metabolomics of pancreatic cancer patients. They have been identified as pre-diagnostic and diagnostic markers and associated with pancreatic cancer risk factors. Read More

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http://dx.doi.org/10.21873/anticanres.13314DOI Listing

Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma.

Anticancer Res 2019 Apr;39(4):2025-2033

Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.

Background/aim: Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients.

Patients And Methods: Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016. Read More

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http://dx.doi.org/10.21873/anticanres.13313DOI Listing
April 2019
2 Reads

Extracorporeal Irradiation and Reimplantation of Tumor-bearing Bone Segments Following Diaphyseal Sarcoma Resection at the Tibia.

Anticancer Res 2019 Apr;39(4):2015-2023

Department of Plastic and Hand Surgery, University Hospital, Basel, Switzerland.

Background/aim: Reconstruction of diaphyseal tibial sarcomas with extracorporeal irradiated autograft is a rarely applied technique and is analyzed in this study.

Patients And Methods: Eight patients with malignant sarcomas received local treatment by means of a wide resection and reimplantation of an extracorporeally-irradiated autograft. The graft was combined with an ipsilateral vascularized fibula when a full-thickness segment of the tibia had to be resected and no cortex could be preserved (n=5). Read More

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http://dx.doi.org/10.21873/anticanres.13312DOI Listing
April 2019
1 Read

Hospital Volume Threshold for the Treatment of Retroperitoneal Sarcoma.

Anticancer Res 2019 04;39(4):2007-2014

Department of Surgery, Duke University Medical Center, Durham, NC, U.S.A.

Background: Retroperitoneal sarcomas (RPS) are rare, histologically heterogeneous, and anatomically complex tumors. National Comprehensive Cancer Network guidelines recommend evaluation and management by multidisciplinary teams with experience in sarcoma. Our aim was to determine an appropriate hospital volume threshold for the treatment of RPS. Read More

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http://dx.doi.org/10.21873/anticanres.13311DOI Listing
April 2019
1 Read

Induction of CD3+ and FoxP3+ T Cells in Left-sided Colorectal Tumors After UFT/LV Chemotherapy.

Anticancer Res 2019 Apr;39(4):1997-2005

Pharmacology Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.

Background/aim: Immune checkpoint inhibitors are mainly used for right-sided, microsatellite instability-high colorectal tumors. In this study, the effects of oral uracil-tegafur plus leucovorin (UFT/LV) chemotherapy on the gene expressions of four immunotherapy targets and the amounts of tumor-infiltrating lymphocytes (TILs) were investigated.

Patients And Methods: Data of 260 patients with stage II or stage III colorectal cancer were analyzed. Read More

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http://dx.doi.org/10.21873/anticanres.13310DOI Listing

Association of Low Body Mass Index With Poor Clinical Outcomes After Resection of Non-small Cell Lung Cancer.

Anticancer Res 2019 Apr;39(4):1987-1996

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background/aim: This study was performed to evaluate the influence of the body mass index (BMI) on disease-free survival and overall survival (DFS and OS) in patients with resected non-small cell lung cancer (NSCLC).

Patients And Methods: Overall, 546 of 780 (70%) patients with stage I to III NSCLC who underwent surgical resection were randomly selected. The patients were subdivided into three groups: low BMI (<18. Read More

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http://dx.doi.org/10.21873/anticanres.13309DOI Listing
April 2019
1 Read

Non-odontogenic Intraosseous Radiolucent Lesions of the Mandibular Body Are Rare Findings on Panoramic Views of Patients With Neurofibromatosis Type 1.

Anticancer Res 2019 Apr;39(4):1971-1985

Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Background/aim: The purpose of the study was to investigate whether non-odontogenic intraosseous translucent lesions of mandibular body are depicted on radiographs of patients with neurofibromatosis type 1 (NF1).

Materials And Methods: The panoramic radiographs of 179 NF1 patients were analysed for translucent lesions of the mandibular body that were of intraosseous, non-odontogenic origin. The results were compared to findings obtained in panoramic radiographs of age- and sex-matched controls. Read More

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http://dx.doi.org/10.21873/anticanres.13308DOI Listing
April 2019
1 Read

Determining Patient Satisfaction and Treatment Desires in Patients With Musculoskeletal Sarcoma of the Knee After Joint-preservation Surgery Using a Questionnaire Survey.

Anticancer Res 2019 Apr;39(4):1965-1969

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Background/aim: For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed.

Patients And Methods: Surveys were mailed to 62 patients with musculoskeletal sarcoma of the knee. Read More

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http://dx.doi.org/10.21873/anticanres.13307DOI Listing
April 2019
1 Read

Satisfaction After Joint-preservation Surgery in Patients With Musculoskeletal Knee Sarcoma Based on Various Scores.

Anticancer Res 2019 Apr;39(4):1959-1964

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Background/aim: At our institute, we prioritize joint-preservation whenever possible in cases of musculoskeletal knee sarcoma. This study aimed to evaluate patient satisfaction after joint-preservation surgery using different scales.

Patients And Methods: Surveys were mailed to 62 patients with musculoskeletal knee sarcoma. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13306DOI Listing
April 2019
2 Reads

Cytoplasmic E-Cadherin Expression Is Associated With Higher Tumour Level of VEGFA, Lower Response Rate to Irinotecan-based Treatment and Poorer Prognosis in Patients With Metastatic Colorectal Cancer.

Anticancer Res 2019 Apr;39(4):1953-1957

Department of Oncology and Radiotherapy, Turku University Hospital and University of Turku, Turku, Finland.

Background: The prognostic value of vascular endothelial growth factor-A (VEGFA) and epithelial cadherin (E-cadherin) expression in patients with metastatic colorectal cancer (mCRC) is controversial.

Materials And Methods: In this prospective study, patients diagnosed with mCRC between August 1, 1998, and August 30, 2003, at the Turku University Hospital, Finland were included. Expression of E-cadherin (membranous and cytoplasmic pattern) and VEGFA in tumour samples was assessed by immunohistochemistry. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13305DOI Listing
April 2019
4 Reads
1.872 Impact Factor

Characterization of Bone Lesions in Myeloma Before and During Anticancer Therapy Using F-FDG-PET/CT and F-NaF-PET/CT.

Anticancer Res 2019 Apr;39(4):1943-1952

Department of Internal Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.

Background: The objective of this study was to characterize tumor activity and mineralization status in newly-detected multiple myeloma (MM) bone lesions using 2-F-fluoro-2-deoxy-D-glucose (F-FDG)-PET/CT and F-sodium fluoride (F-NaF)-PET/CT before and after antitumor treatment.

Materials And Methods: In this retrospective study, seven patients with histologically-verified MM were included (four women, three men; median age=57 years, standard deviation=11.23 years). Read More

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http://dx.doi.org/10.21873/anticanres.13304DOI Listing
April 2019
1 Read

CD2 for Prevention of Oral Mucositis in Patients With Head and Neck Tumors: A Multicentric Randomized Study.

Anticancer Res 2019 04;39(4):1935-1942

Radiation Oncology, A.S.O. S. Croce e Carle, Cuneo, Italy.

Background: Oropharyngeal mucositis occurs in virtually all patients with head and neck cancer receiving radiochemotherapy. The manipulation of the oral cavity microbiota represents an intriguing and challenging target.

Patients And Methods: A total of 75 patients were enrolled to receive Lactobacillus brevis CD2 lozenges or oral care regimen with sodium bicarbonate mouthwashes. Read More

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http://dx.doi.org/10.21873/anticanres.13303DOI Listing
April 2019
2 Reads
1.872 Impact Factor

Frequent and Specific Involvement of Changes of the p16-RB Pathway in Esophageal Neuroendocrine Carcinoma.

Anticancer Res 2019 Apr;39(4):1927-1934

Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.

Aim: This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer.

Materials And Methods: Immunohistochemical staining was performed using the avidin-biotin complex detection method. The staining was evaluated as diffusely positive, heterogeneous (in 5-95% of tumor cells), or diffusely negative. Read More

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http://dx.doi.org/10.21873/anticanres.13302DOI Listing
April 2019
4 Reads

Mifepristone Extends Both Length and Quality of Life in a Patient With Advanced Non-small Cell Lung Cancer that Has Progressed Despite Chemotherapy and a Check-point Inhibitor.

Anticancer Res 2019 Apr;39(4):1923-1926

Kennedy Medical Campus, Sewell, NJ, U.S.A.

Case Report: Case 1 of an investigator-initiated study using oral single agent mifepristone to halt stage IV non-small cell lung cancer whose tumor was devoid of any targeted markers has remained ECOG zero and in good health for over 3 years. Case 2, reported here, is a 68-year-old woman with stage IV non-small cell lung cancer whose tumor was positive for the programmed death ligand-1 (PD-L1) marker. Her cancer progressed despite treatment with a check-point inhibitor (nivolumab), besides 3 rounds of multi-agent chemotherapy. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13301DOI Listing
April 2019
4 Reads

Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer.

Anticancer Res 2019 Apr;39(4):1915-1921

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Aim: We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer.

Patients And Methods: Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose-volume parameters (V, V, V, and D) of the rectum, sigmoidal colon, and bladder were evaluated. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13300DOI Listing
April 2019
2 Reads

HPV Status and Survival in Non-Oropharyngeal Squamous Cell Carcinoma of the Head and Neck.

Anticancer Res 2019 Apr;39(4):1907-1914

Department of Internal Medicine, Division of Oncology-Hematology, VA Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, U.S.A.

Background/aim: HPV-mediated oropharyngeal squamous cell carcinoma is associated with an increased survival. The prognostic value of HPV status for other primary sites is unclear. We aimed to assess the effect of HPV status on overall survival in patients with non-oropharyngeal head and neck squamous cell carcinoma (non-OPSCC) using the National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.21873/anticanres.13299DOI Listing
April 2019
1 Read

Effect of Stem Cell Transplant on Survival in Adult Patients With Acute Lymphoblastic Leukemia: NCDB Analysis.

Anticancer Res 2019 Apr;39(4):1899-1906

Department of Medicine, Section of Hematology/Oncology, Feist-Weiller Cancer Center, Louisiana State University Health Science Center, Shreveport, LA, U.S.A.

Background: A retrospective analysis was performed to investigate the survival outcomes in adult acute lymphoblastic leukemia (ALL) based on treatment received.

Materials And Methods: Data from 17,504 men and women (≥18 years of age) registered in the National Cancer Database who were diagnosed with ALL between 2004 and 2013 and had follow-up to the end of 2014, were analyzed. The primary predictor variable was treatment received, and overall survival was the outcome variable. Read More

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http://dx.doi.org/10.21873/anticanres.13298DOI Listing
April 2019
2 Reads
1.872 Impact Factor

Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth.

Anticancer Res 2019 Apr;39(4):1893-1898

Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga, Japan.

Background/aim: γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers.

Materials And Methods: Immuno-histochemistry was used to evaluate GGCT expression in bladder tumors. Read More

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http://dx.doi.org/10.21873/anticanres.13297DOI Listing

Antitumor and Apoptosis-inducing Effects of Piperine on Human Melanoma Cells.

Anticancer Res 2019 Apr;39(4):1883-1892

Department of Companion and Laboratory Animal Science, Kongju National University, Yesan, Republic of Korea

Background/aim: Piperine is a major pungent alkaloid present in black pepper (Piper nigrum L). This study investigated the potential anticancer effects of piperine on human melanoma cells and explored the potential pharmacological mechanisms in vitro and in vivo.

Materials And Methods: Studies were performed using the MTT assay, 4',6-diamidino-2-phenylindole (DAPI) staining, western blotting, a xenograft model, the terminal deoxynucleotidyl transferase dUTP nick end labeling assay, and immunohistochemistry. Read More

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http://dx.doi.org/10.21873/anticanres.13296DOI Listing
April 2019
2 Reads

Serial Texture Analyses on ADC Maps for Evaluation of Antiangiogenic Therapy in Rat Breast Cancer.

Anticancer Res 2019 Apr;39(4):1875-1882

Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

Background/aim: We investigated the correlation between texture features on apparent diffusion coefficient (ADC) maps and histological vascular parameters of FN13762 rat breast cancers after antiangiogenic therapy.

Materials And Methods: FN13762 cancer cells were implanted into 30 rats, and bevacizumab was intraperitoneally administered to 15 (treated group). For each rat, magnetic resonance imaging (MRI) was obtained at five time points after baseline examination. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13295DOI Listing
April 2019
3 Reads

IL6 Shapes an Inflammatory Microenvironment and Triggers the Development of Unique Types of Cancer in End-stage Kidney.

Anticancer Res 2019 Apr;39(4):1869-1874

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: Chronic inflammation in end-stage kidney is associated with the development of pre-neoplastic lesions and renal cell tumors. The aim of this study was to clarify the role of the inflammatory microenvironment in this process.

Materials And Methods: We used representative microscopic slides from 11 end stage-kidneys containing pre-neoplastic lesions and tumors and applied immunohistochemistry to detect IL-6, SAA1 and LBP expression. Read More

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http://dx.doi.org/10.21873/anticanres.13294DOI Listing
April 2019
1 Read

Anti-MUC1 Aptamer as Carrier Tool of the Potential Radiosensitizer Phenanthroline in MCF-7 Breast Cancer 1,10 Cells.

Anticancer Res 2019 Apr;39(4):1859-1867

Laboratory of Radiobiology, Division of Medical Physics, Institute of Radioprotection and Dosimetry, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil

Background: Proteins overexpressed in malignant tissues form important targets in the development of targeted therapeutics, and aptamers comprise an important affinity agent for therapy and drug delivery. In this study, aberrantly expressed mucin 1 glycoprotein was investigated as a therapeutic target in a breast cancer model.

Materials And Methods: In order to determine the feasibility of using an aptamer against mucin 1 (aptA) as carrier of the cytotoxic compound 1,10-phenanthroline to MCF-7 cells, as a potential radiosensitizer, was studied in experiments using circular dichroism and rhodamine labelling by fluorescent microscopy and flow cytometry. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13293DOI Listing
April 2019
5 Reads

Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma.

Anticancer Res 2019 Apr;39(4):1849-1857

Department of Dermatology, Yanbian University Hospital, Yanji, P.R. China

Background/aim: Melanoma-associated antigen A12 (MAGEA12) has recently been reported as a repressor of tumor-suppressor genes. This study aimed to investigate the implications of MAGEA12 expression in the pathogenesis of cutaneous squamous cell carcinoma (cSCC).

Materials And Methods: MAGEA12 and p21 expression were investigated in 15 samples of normal skin and 111 of cSCC tissues by immunohistochemistry. Read More

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http://dx.doi.org/10.21873/anticanres.13292DOI Listing

Casticin Induces DNA Damage and Impairs DNA Repair in Human Bladder Cancer TSGH-8301 Cells.

Anticancer Res 2019 Apr;39(4):1839-1847

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.

Background/aim: Casticin shows anti-cancer effects in many types of cancer. However, there is no information regarding its role in DNA damage in human bladder cancer. The aim of this study was to investigate the effects of casticin on TSGH-8301 cells in vitro. Read More

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http://dx.doi.org/10.21873/anticanres.13291DOI Listing
April 2019
1 Read

Circulating Tumor Cells With Epithelial-to-mesenchymal Transition Phenotypes Associated With Inferior Outcomes in Primary Breast Cancer.

Anticancer Res 2019 Apr;39(4):1829-1837

2nd Department of Oncology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.

Background/aim: Circulating tumor cells (CTCs) comprise a heterogeneous population of cancer cells with different clinical and biological value. The aim of this study was to evaluate the prognostic value of CTCs with an epithelial-mesenchymal transition (EMT) phenotype in primary breast cancer (PBC) patients.

Patients And Methods: This study included 427 primary breast cancer patients. Read More

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http://dx.doi.org/10.21873/anticanres.13290DOI Listing
April 2019
2 Reads