110,071 results match your criteria Anticancer research[Journal]


Cardiotoxicity with trabectedin in the treatment of advanced soft tissue sarcoma.

Anticancer Drugs 2019 Jan;30(1):110-115

Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Trabectedin is used routinely in the palliative management of patients with advanced soft tissue sarcoma. It is not generally considered to be cardiotoxic, and there is no specific caution for its use in patients with a history of cardiac disease or risk factors. Here, we report six cases from a single academic centre where life-threatening cardiotoxicity occurred acutely during treatment with trabectedin. Read More

View Article
January 2019

Cannabis-related cognitive impairment: a prospective evaluation of possible influences on patients with cancer during chemotherapy treatment as a pilot study.

Anticancer Drugs 2019 Jan;30(1):91-97

Neuro-Cognitive Unit, Rambam Health Care Campus.

Objectives: In patients with cancer, the use of medical cannabis has increased significantly during the recent years. There is evidence that cannabis consumption may affect cognitive performance; however, this potential effect has not been investigated prospectively in patients with cancer to date. We aimed to evaluate the effect of cannabis consumption on cognitive abilities as well as on symptom relief in patients with cancer during chemotherapy treatment. Read More

View Article
January 2019

Aurora kinase B inhibitor barasertib (AZD1152) inhibits glucose metabolism in gastric cancer cells.

Anticancer Drugs 2019 Jan;30(1):19-26

Cancer Institute.

Barasertib is a highly selective Aurora kinase B (AURKB) inhibitor and has been widely applied in a variety of cancer cells to investigate the regulatory function of AURKB. However, the effect of barasertib on glucose metabolism in gastric cancer (GC) remains illustrated. Here, barasertib was identified to effectively reduce glucose uptake and lactate production in GC cells in a dose-dependent and time-dependent manner. Read More

View Article
January 2019
1 Read

Artemisinin and its derivatives: a potential treatment for leukemia.

Anticancer Drugs 2019 Jan;30(1):1-18

Department of Pathology.

Artemisinin (ART) and its derivatives are one of the most important classes of antimalarial agents, originally derived from a Chinese medicinal plant called Artemisia annua L. Beyond their outstanding antimalarial and antischistosomal activities, ART and its derivatives also possess both in-vitro and in-vivo activities against various types of cancer. Their anticancer effects range from initiation of apoptotic cell death to inhibition of cancer proliferation, metastasis and angiogenesis, and even modulation of the cell signal transduction pathway. Read More

View Article
January 2019

Autophagy and intermittent fasting: the connection for cancer therapy?

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e814s. Epub 2018 Dec 10.

Departamento de Farmacologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, SP, BR.

Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Read More

View Article
December 2018

Natural products as new antimitotic compounds for anticancer drug development.

Clinics (Sao Paulo) 2018 Dec 10;73(suppl 1):e813s. Epub 2018 Dec 10.

Laboratorio de Oncologia Experimental, Nucleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Universidade Federal do Ceara, Fortaleza, CE, BR.

Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. Read More

View Article
December 2018

Synthesis and characterization of cyclohexane-1R,2R-diamine-based Pt(iv) dicarboxylato anticancer prodrugs: their selective activity against human colon cancer cell lines.

Dalton Trans 2018 Dec 12. Epub 2018 Dec 12.

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.

Three pairs of asymmetric dicarboxylato derivatives based on the cisplatin and oxaliplatin-like skeletons have been synthesized de novo or re-synthesized. The axial ligands consist of one medium-chain fatty acid (MCFA), namely clofibrate (i.e. Read More

View Article
December 2018

Combinatorial effect of curcumin and tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) in induction of apoptosis via inhibition of nuclear factor kappa activity and enhancement of caspase-3 activity in chronic myeloid cells: An study.

J Cancer Res Ther 2018 Dec;14(Supplement):S1193-S1200

Department of Biochemistry, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Nuclear factor kappa B (NFkB-light-chain-enhancer of activated B-cells) expression and its regulation is a key role in the development of number of malignancies, as NFkB mediates the balance between cell death and its survival. Therefore, NFkB regulation constitutes an attractive target to overcome the resistance to chemotherapeutic agents in anticancer therapy. Curcumin, as a chemopreventive agent, has a potential role in inhibiting cell growth in a variety of malignancies. Read More

View Article
December 2018

Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells.

J Cancer Res Ther 2018 Dec;14(Supplement):S1141-S1147

Department of General Surgery, Institute of General Surgery, General Hospital, Tianjin Medical University, Tianjin, P.R. China.

Aim Of Study: The roles of autophagy performed in chemotherapy-induced cell death or proliferation inhibition were still in debate. In this study, we aimed to disclose the function of autophagy in chemotherapy of HCT-116 colon cells.

Materials And Methods: Pharmacological and genetic methods were applied to induce and inhibit autophagy and elucidate the roles of autophagy performed in chemotherapy-induced proliferation inhibition and apoptosis. Read More

View Article
December 2018

Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine.

J Cancer Res Ther 2018 Dec;14(Supplement):S1035-S1040

Department of Medical Imageology, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.

Aim: Norcantharidin (NCTD) has been used as a clinical antineoplastic drug in China for several years, and diamminedichloroplatinum is a valuable clinical cancer chemotherapy agent. Here, we tried to investigate the effects of NCTD plus diamminedichloroplatinum on hepatic carcinoma in murine.

Materials And Methods: In vivo and in vitro investigations on anticancer effects of the two drugs were individually made. Read More

View Article
December 2018

Ganodermanontriol inhibits expression of special AT rich sequence binding protein 1 gene in human hepatocellular carcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S964-S968

Department of Epidemiology and Medical Statistics, Guangdong Medical University, Dongguan, Guangdong 523808, China, Dongguan.

Context: The metastasis of liver cancer is a major cause of clinical treatment failure, restrain, and control the cancer metastasis is the major strategy of the treatment and prevention of the disease. Special AT-rich sequence-binding protein 1 (SATB1) gene was overexpressed in many malignant tumors and considered as a potential target of anticancer drug. This study investigated the mechanism how ganodermanontriol effect the expression of SATB1 and thus inhibits the growth and metastasis in hepatocellular carcinoma (HCC). Read More

View Article
December 2018

Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway.

J Cancer Res Ther 2018 Dec;14(Supplement):S942-S947

Department of Respiratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Aim Of The Study: Garcinia hanburyi is a traditional herbal medicine with activities of anti-inflammation and hemostasis used by people in South Asia. Gambogic acid (GA) is the main active component extracted from it, which has anticancer and anti-inflammatory effects. The aim of the current study is to investigate the molecular mechanisms of GA's effective anticancer activity. Read More

View Article
December 2018

Madhuca indica inhibits breast cancer cell proliferation by modulating COX-2 expression.

Curr Mol Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata-700026. India.

Background: Madhuca indica belongs to the family sapotaceae, commonly known as Mahua. It is primarily known for alcoholic beverage production and is reported to have anti-inflammatory, analgesic and antipyretic properties. Madhuca indica has also been reported to be effective in several diseases. Read More

View Article
December 2018

Design and synthesis of some β-carboline derivatives as multi-target anticancer agents.

Future Med Chem 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Aim: Some anticancer β-carbolines exhibited dual inhibition of topo-I and KSP.

Methodology/results: Novel β-carbolines were synthesized and screened for their anticancer activity according to the NCI protocol. Five dose assays results indicated that compounds 9, 10, 12, 17 and 20 were potent and non selective anticancer agents; the sulfanyltriazole 12 was the most potent. Read More

View Article
December 2018

Combinatory Cancer Therapeutics with Nanoceria-capped Mesoporous Silica Nanocarriers Through pH-triggered Drug Release and Redox Activity.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

In the field of nanomedicine, drug-loaded nanocarriers that integrate nanotechnology and chemotherapeutics are widely used to achieve synergistic therapeutic effects. Here we prepared mesoporous silica nanoparticles capped with cerium oxide nanoparticles (COP@MSN) where a pH triggered-responsive mechanism was used to control drug release and intracellular drug delivery. We blocked the mesopores of the carboxyl functionalized MSN with aminated COP. Read More

View Article
December 2018

Screening of Plants Used as Traditional Anticancer Remedies in Mkuranga and Same Districts, Tanzania, Using Brine Shrimp Toxicity Bioassay.

Evid Based Complement Alternat Med 2018 14;2018:3034612. Epub 2018 Nov 14.

Department of Biological and Preclinical Studies, Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.

Background: Inadequate specialized cancer hospitals and high costs are contributing factors that delay cancer patients from accessing health care services in Tanzania. Consequently, majority of patients are first seen by Traditional Health Practitioners (THPs) before they access specialized services. This study presents ethnomedical information and preliminary evaluation of 25 plant species claimed by THPs in Mkuranga and Same districts of Tanzania on use for treatment of cancer. Read More

View Article
November 2018

The and Anticancer Properties of .

Evid Based Complement Alternat Med 2018 14;2018:1071243. Epub 2018 Nov 14.

Integrative Medicine Cluster, Institut Perubatan dan Pergigian Termaju (IPPT), Sains@BERTAM, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia.

, a fast-growing deciduous tree that is widely cultivated in tropical and subtropical regions of the world, is well known for its abundant uses. The tree is a source of food, shelter, and traditional medicine for many people, especially in developing countries. Many studies have been conducted to evaluate the various claims of traditional medicine practitioners that the moringa tree can improve health and treat various diseases. Read More

View Article
November 2018

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop.

Front Immunol 2018 27;9:2762. Epub 2018 Nov 27.

State Key Laboratory of Natural Products, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.

Artemisinins have been reported to have diverse functions, such as antimalaria, anticancer, anti-inflammation, and immunoregulation activities. DC32 [(9α,12α-dihydroartemisinyl) bis(2'-chlorocinnmate)], a dihydroartemisinin derivative possessing potent immunosuppressive properties, was synthesized in our previous study. Collagen-induced arthritis (CIA) in DBA/1 mice and inflammatory model in NIH-3T3 cells were established to evaluate the effect of DC32 on RA and discover the underlying mechanisms. Read More

View Article
November 2018

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects.

Front Pharmacol 2018 27;9:1374. Epub 2018 Nov 27.

Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Cancer is still a severe threat to the health of people worldwide. Chemotherapy is one of main therapeutic approaches to combat cancer. However, chemotherapy only has a limited success with severe side effects, especially causing damage to normal tissues such as bone marrow, gastrointestine, heart, liver, renal, neuron, and auditory tissues, etc. Read More

View Article
November 2018

The effect of piperlongumine on endothelial and lung adenocarcinoma cells with regulated expression of profilin-1.

Onco Targets Ther 2018 22;11:8275-8292. Epub 2018 Nov 22.

Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland,

Purpose: The aim of the study was to evaluate the effect of piperlongumine (2 and 4 µM) on endothelial EA.hy926 and lung adenocarcinoma A549 cells with regulated expression of profilin-1 (PFN1).

Material And Methods: The cytotoxicity of alkaloid was evaluated by MTT assay, while cell death was assessed using double staining with annexin V and propidium iodide. Read More

View Article
November 2018

Icotinib inhibits the proliferation of hepatocellular carcinoma cells in vitro and in vivo dependently on EGFR activation and PDL1 expression.

Onco Targets Ther 2018 21;11:8227-8237. Epub 2018 Nov 21.

Department of Liver Transplantation, Tianjin First Center Hospital, First Clinical Institute of Tianjin Medical University, Nan Kai District, Tianjin 300192, People's Republic of China,

Purpose: Hepatocellular carcinoma (HCC) accounts for one of the most prevalent tumor types in the world and still lacks an effective treatment regimen. The EGFR tyrosine-kinase inhibitor icotinib is capable of inhibiting proliferation of several kinds of cancer cells, but its anticancer effect in HCC is still not verified.

Methods: In the current study, ten HCC cell lines were selected to test their original EGFR-activation status and PDL1 protein level, and in vitro antiproliferation assays were also conducted to analyze the IC and further investigate the correlation between IC and protein level of phosphorylated EGFR and PDL1. Read More

View Article
November 2018

Fabrication and evaluation of a γ-PGA-based self-assembly transferrin receptor-targeting anticancer drug carrier.

Int J Nanomedicine 2018 22;13:7873-7889. Epub 2018 Nov 22.

School of Life Sciences, East China Normal University, Shanghai 200241, China,

Background: cis-Dichlorodiamineplatinum (CDDP) was one of the most common used drugs in clinic for cancer treatment. However, CDDP caused a variety of side effects. The abundant carboxyl groups on the surface of poly glutamic acid (PGA) could be modified with various kinds of targeted ligands. Read More

View Article
November 2018

Biogenic pentagonal silver nanoparticles for safer and more effective antibacterial therapeutics.

Int J Nanomedicine 2018 21;13:7789-7799. Epub 2018 Nov 21.

Nanomedicine & Nanobiotechnology Lab, Department of Biosciences, Integral University, Dasauli, Lucknow, India,

Background: Biological synthesis of nanomaterials possesses unprecedented potential in the production of nanomaterials due to their ability to produce nanomaterials with improved biocompatibility in addition to eco-friendly synthetic procedures.

Methods: This article reports the isolation of an air-borne fungus from the campus of Integral University, Lucknow, with an exceptional ability to withstand very high concentrations of silver salt. The fungus was found to produce pentagonal silver nanoparticles (AgPgNps) when silver ions were reduced from silver nitrate. Read More

View Article
November 2018

Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity.

Int J Nanomedicine 2018 20;13:7771-7787. Epub 2018 Nov 20.

Department of Drug Science, University of Catania, Catania, Italy.

Purpose: Anticancer drug delivery systems are often limited by hurdles, such as off-target distribution, slow cellular internalization, limited lysosomal escape, and drug resistance. To overcome these limitations, we have developed a stable nitric oxide (NO)-releasing nanoparticle (polystyrene-maleic acid [SMA]--dodecane S-nitrosothiol [tDodSNO]) with the aim of enhancing the anticancer properties of doxorubicin (Dox) and a Dox-loaded nanoparticle (SMA-Dox) carrier.

Materials And Methods: Effects of SMA-tDodSNO and/or in combination with Dox or SMA-Dox on cell viability, apoptosis, mitochondrial membrane potential, lysosomal membrane permeability, tumor tissue, and tumor growth were studied using in vitro and in vivo model of triple-negative breast cancer (TNBC). Read More

View Article
November 2018

Novel pH-sensitive zinc phthalocyanine assembled with albumin for tumor targeting and treatment.

Int J Nanomedicine 2018 19;13:7681-7695. Epub 2018 Nov 19.

College of Chemistry, Fuzhou University, Fuzhou, Fujian, China.

Purpose: Zinc phthalocyanine (ZnPc) has been applied widely in photodynamic therapy (PDT) with high ROS-production capacity and intense absorption in the near-infrared region. However, weak tumor targeting and the aggregation tendency of ZnPc seriously affect the therapeutic effect of PDT. Therefore, overcoming the aggregation of ZnPc and enhancing its antitumor effect were the purpose of this study. Read More

View Article
November 2018

Decapeptide functionalized targeted mesoporous silica nanoparticles with doxorubicin exhibit enhanced apoptotic effect in breast and prostate cancer cells.

Int J Nanomedicine 2018 19;13:7669-7680. Epub 2018 Nov 19.

Nanobioscience Group, Agharkar Research Institute, Pune, India,

Background: Considering the increase in cancer cases and number of deaths per year worldwide, development of potential therapeutics is imperative. Mesoporous silica nanoparticles (MSNPs) are among the potential nanocarriers having unique properties for drug delivery. Doxorubicin (DOX), being the most commonly used drug, can be efficiently delivered to gonadotropin-releasing hormone (GnRH)-overexpressing cancer cells using functionalized MSNPs. Read More

View Article
November 2018

Design Optimization of Tumor Vasculature-Bound Nanoparticles.

Sci Rep 2018 Dec 11;8(1):17768. Epub 2018 Dec 11.

Department of Mechanical Engineering, McGill University, Montreal, Quebec, Canada.

Nanotherapy may constitute a promising approach to target tumors with anticancer drugs while minimizing systemic toxicity. Computational modeling can enable rapid evaluation of nanoparticle (NP) designs and numerical optimization. Here, an optimization study was performed using an existing tumor model to find NP size and ligand density that maximize tumoral NP accumulation while minimizing tumor size. Read More

View Article
December 2018

Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.

J Cardiol Cases 2013 Jun 18;7(6):e176-e180. Epub 2013 Mar 18.

Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 2-50-1 Kuramoto-cho, Tokushima 770-8503, Japan.

The two patients were males aged over 30 years. To treat testicular tumors, combination chemotherapy with bleomycin, etoposide, and cisplatin (BEP) had been employed. In case 1, during the 4th course of BEP therapy, thoracic pain suddenly appeared. Read More

View Article
June 2013
1 Read

Hypertension-induced posterior reversible encephalopathy syndrome as the presentation of progressive bilateral renal artery stenosis.

J Cardiol Cases 2011 Dec 4;4(3):e168-e171. Epub 2011 Oct 4.

Second Division of Internal Medicine and Hypertension Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.

Posterior reversible encephalopathy syndrome (PRES) is characterized clinically by headache, altered mental status, visual loss, and seizures. PRES is associated with neuroradiological findings characterized by white matter abnormalities, predominantly in the parieto-occipital regions of the brain. PRES is most often described in cases of hypertensive encephalopathy, eclampsia, renal failure, and immunosuppressive or anticancer therapy. Read More

View Article
December 2011

A Robust Model-Free Feature Screening Method for Ultrahigh-Dimensional Data.

J Comput Graph Stat 2017 9;26(4):803-813. Epub 2017 Oct 9.

Department of Biostatistics, University of Florida, Gainesville, FL 32611.

Feature screening plays an important role in dimension reduction for ultrahigh-dimensional data. In this paper, we introduce a new feature screening method and establish its sure independence screening property under the ultrahigh-dimensional setting. The proposed method works based on the nonparanormal transformation and Henze-Zirkler's test; that is, it first transforms the response variable and features to Gaussian random variables using the nonparanormal transformation and then tests the dependence between the response variable and features using the Henze-Zirkler's test. Read More

View Article
October 2017

Kojic acid applications in cosmetic and pharmaceutical preparations.

Biomed Pharmacother 2018 Dec 8;110:582-593. Epub 2018 Dec 8.

Student Research Committee, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Skin color disorders can be caused by various factors, such as excessive exposure to sunlight, aging and hormonal imbalance during pregnancy, or taking some medications. Kojic acid (KA) is a natural metabolite produced by fungi that has the ability to inhibit tyrosinase activity in synthesis of melanin. The major applications of KA and its derivatives in medicine are based on their biocompatibility, antimicrobial and antiviral, antitumor, antidiabetic, anticancer, anti-speck, anti-parasitic, and pesticidal and insecticidal properties. Read More

View Article
December 2018
3 Reads

Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme.

J Colloid Interface Sci 2018 Dec 4;538:449-461. Epub 2018 Dec 4.

Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy; Politecnico di Torino, Department of Mechanical and Aerospace Engineering, Corso Duca degli Abruzzi 24, 10129 Torino, Italy. Electronic address:

Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca and K homeostasis and by affecting the organization of the mitotic spindles. However, to preserve healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. Read More

View Article
December 2018

A novel MUC1 aptamer-modified PLGA-epirubicin-PβAE-antimir-21 nanocomplex platform for targeted co-delivery of anticancer agents in vitro and in vivo.

Colloids Surf B Biointerfaces 2018 Dec 4;175:231-238. Epub 2018 Dec 4.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Conventional chemotherapy suffers from several drawbacks, including toxic side effects together with the development of resistance to the chemical agents. Therefore, exploring alternative therapeutic approaches as well as developing targeted delivery systems are in demand. Oligonucleotide-based therapy has emerged as a promising and alternative procedure for treating malignancies involving gene-related diseases. Read More

View Article
December 2018

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers.

Chem Rec 2018 Dec 10. Epub 2018 Dec 10.

Epigenetic Chemical Biology, Institut Pasteur, CNRS UMR3523, 28 rue du Docteur Roux, 75724, Paris cedex 15, France.

DNA methylation and histone acetylation are widely studied epigenetic modifications. They are involved in numerous pathologies such as cancer, neurological disease, inflammation, obesity, etc. Since the discovery of the epigenome, numerous compounds have been developed to reverse DNA methylation and histone acetylation aberrant profile in diseases. Read More

View Article
December 2018

Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.

Phytother Res 2018 Dec 9. Epub 2018 Dec 9.

The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA.

Protopanaxadiol (PPD), a ginseng metabolite generated by the gut bacteria, was shown to induce colorectal cancer cell death and enhance the anticancer effect of chemotherapeutic agent 5-FU. However, the mechanism by which PPD promotes cancer cell death is not clear. In this manuscript, we showed that PPD activated p53 and endoplasmic reticulum (ER) stress and induced expression of BH3-only proteins Puma and Noxa to promote cell death. Read More

View Article
December 2018

Anti-oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient-derived tumor xenograft model.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

School of Dentistry, National Defense Medical Center, Taipei, Taiwan.

Background: Aberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human cancers. The aim of this study was to assess DcR3 as a target of the anticancer effects of triptolide (TPL) in preclinical patient-derived tumor xenograft (PDTX) models of oral squamous cell carcinoma (OSCC).

Methods: The expression of DcR3 was evaluated through immunohistochemistry, and correlations were examined using clinical variables. Read More

View Article
December 2018

A multi-step virtual screening protocol for identification of novel non-acidic microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.

ChemMedChem 2018 Dec 11. Epub 2018 Dec 11.

Gazi Universitesi Eczacilik Fakultesi, Pharmaceutical Chemistry, Tac Sokak No 3, 06580, Ankara, TURKEY.

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is considered as potential therapeutic target for treatment of inflammatory diseases and certain types of cancer. In order to capture novel scaffolds for mPGES-1 inhibition, we applied a virtual screening protocol comprising molecular docking, fingerprints-based clustering with diversity-based selection, protein-ligand interactions fingerprints, and molecular dynamics (MD) simulations with Molecular Mechanic-Poisson Boltzmann Surface Area (MM-PBSA) calculation. The hits identified were carefully analyzed to ensure the selection of novel scaffolds, which make stable interactions with key residues in the mPGES-1 binding pocket and inhibit the catalytic activity of the enzyme. Read More

View Article
December 2018

Transforming Weakness into Strength: Photothermal-Therapy-Induced Inflammation Enhanced Cytopharmaceutical Chemotherapy as a Combination Anticancer Treatment.

Adv Mater 2018 Dec 9:e1805936. Epub 2018 Dec 9.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing, 210009, China.

A new synergistic treatment that combines photothermal therapy (PTT) and inflammation-mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the photothermal tumor ablation is accompanied by an inflammatory effect and upregulation of inflammatory factors at the tumor site, which may accelerate tumor regeneration. Moreover, PTT-induced inflammation can also recruit neutrophils (NEs) to the tumor site. Read More

View Article
December 2018

Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Chemistry, Graduate School of Science, Chiba University, Chiba, Japan.

Diacylglycerol (DG) kinase (DGK), which phosphorylates DG to generate phosphatidic acid (PA), consists of ten isozymes (α-к). Recently, we identified a novel small molecule inhibitor, CU-3, that selectively inhibits the activity of the α isozyme. In addition, we newly obtained Compound A, which selectively and strongly inhibits type I DGKs (α, β, and γ). Read More

View Article
December 2018

Nanocatalysts-Augmented and Photothermal-Enhanced Tumor-Specific Sequential Nanocatalytic Therapy in Both NIR-I and NIR-II Biowindows.

Adv Mater 2018 Dec 9:e1805919. Epub 2018 Dec 9.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China.

The tumor microenvironment (TME) has been increasingly recognized as a crucial contributor to tumorigenesis. Based on the unique TME for achieving tumor-specific therapy, here a novel concept of photothermal-enhanced sequential nanocatalytic therapy in both NIR-I and NIR-II biowindows is proposed, which innovatively changes the condition of nanocatalytic Fenton reaction for production of highly efficient hydroxyl radicals (•OH) and consequently suppressing the tumor growth. Evidence suggests that glucose plays a vital role in powering cancer progression. Read More

View Article
December 2018

Modeling and multi-scale characterization of the quantitative imaging based fibrosis index reveals pathophysiological, transcriptome and proteomic correlates of lung fibrosis induced by fractionated irradiation.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Pulmonary fibrosis represents a leading cause of morbidity and mortality worldwide. Therapy induced lung fibrosis constitutes a pivotal dose-limiting side effect of radiotherapy and other anticancer agents. We aimed to develop objective criteria for assessment of fibrosis and discover pathophysiological and molecular correlates of lung fibrosis as a function of fractionated whole thoracic irradiation. Read More

View Article
December 2018

Plumbagin induces autophagy and apoptosis of SMMC-7721 cells in vitro and in vivo.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Physiology, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Plumbagin (PL), an active naphthoquinone compound, has been demonstrated to be a potential anticancer agent. However, the underlying anticancer mechanism is not fully understood. In this study, the human hepatocellular carcinoma (HCC) SMMC-7721 cell line was studied in an in vitro model. Read More

View Article
December 2018

Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2.

Phytother Res 2018 Dec 10. Epub 2018 Dec 10.

China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan, China.

Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities. However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated. In the present study, we report that gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth. Read More

View Article
December 2018
1 Read
2.397 Impact Factor

Berberine reversed the epithelial-mesenchymal transition of normal colonic epithelial cells induced by SW480 cells through regulating the important components in the TGF-β pathway.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Oncology, Affiliated Bao'an Hospital of Shenzhen, Southern Medical University, Shenzhen, China.

Stroma-tumor interactions within microenvironment play a crucial role in tumor development and growth. Cellular transdifferentiation in the stroma is a prerequisite for tumor formation. Targeting the interactions maybe a promising anticancer strategy. Read More

View Article
December 2018

Metformin plus chemotherapy versus chemotherapy alone in the first-line treatment of HER2-negative metastatic breast cancer. The MYME randomized, phase 2 clinical trial.

Breast Cancer Res Treat 2018 Dec 7. Epub 2018 Dec 7.

Division of Oncology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

Purpose: To investigate the efficacy of metformin (M) plus chemotherapy versus chemotherapy alone in metastatic breast cancer (MBC).

Methods: Non-diabetic women with HER2-negative MBC were randomized to receive non-pegylated liposomal doxorubicin (NPLD) 60 mg/m + cyclophosphamide (C) 600 mg/m × 8 cycles Q21 days plus M 2000 mg/day (arm A) versus NPLD/C (arm B). The primary endpoint was progression-free survival (PFS). Read More

View Article
December 2018

Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells.

Appl Biochem Biotechnol 2018 Dec 10. Epub 2018 Dec 10.

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.

Prostate cancer is one of the major causes of cancer-related deaths in men and there is a growing interest in identifying natural compounds for its management. We analyzed bioactive withanolides in Withania coagulans from 11 different sites in Pakistan and evaluated the antiprostate cancer activities of leaf extracts from two sites with the greatest amounts. Total withanolide concentration differed by ~ 17-fold between sites, ranging from 1. Read More

View Article
December 2018

Reconstitution and Characterization of BCL-2 Family Proteins in Lipid Bilayer Nanodiscs.

Methods Mol Biol 2019 ;1877:233-246

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

The BCL-2 family proteins are key regulators of programmed cell death or apoptosis, and represent important targets for the development of anticancer drugs. Because their functions are intimately connected with intracellular membranes, it is important to perform structural and activity studies in precisely characterized samples that include phospholipids and capture the features of the native physiological environment as closely as possible. NMR studies and activity assays based on lipid bilayer nanodiscs are ideally suited for this purpose: they enable the conformations and interactions of these proteins to be probed at atomic resolution in their membrane-associated states. Read More

View Article
January 2019

BH3 Profiling: A Functional Assay to Measure Apoptotic Priming and Dependencies.

Methods Mol Biol 2019 ;1877:61-76

John B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Apoptosis (programmed cell death) is activated by a wide variety of cellular stresses or insults and is vital for proper mammalian development as well as the maintenance of organismal homeostasis. The apoptosis pathway is also engaged by many common types of anticancer therapies and ionizing radiation, which contributes to the regressions of tumors or the toxic side effects of treatment. Due to the importance of maintaining healthy cell survival or the efficient clearance of cancer cells, the BH3 profiling assay was developed to functionally measure the state of the apoptosis pathway in any given cells. Read More

View Article
January 2019

Anticancer Potential of Syzygium Species: a Review.

Plant Foods Hum Nutr 2018 Dec 10. Epub 2018 Dec 10.

Division of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.

Cancer is a preventable and treatable disease, however, the incidence rates are on the rise. Classical treatment modalities for cancer include surgery, radiotherapy and chemotherapy. However, these are associated with detrimental side effects such as nausea and emesis. Read More

View Article
December 2018