22,055 results match your criteria Anticancer Res.[Journal]


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Anticancer Res 2020 May;40(5):3011

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Evaluation of the Irradiated Volume of the Heart and Cardiac Substructures After Left Breast Radiotherapy.

Anticancer Res 2020 May;40(5):3003-3009

School of Health Sciences, Department of Radiotherapy, Faculty of Medicine, Biopolis, University of Thessaly, Larissa, Greece.

Backround/Aim: Adjuvant radiotherapy in patients with cancer of the left breast may lead to impaired cardiac function. The aim of our prospective study is to evaluate (i) doses to the irradiated volume of the heart and its substructures and (ii) determine whether their correlation with changes in strain echo measurements contribute to the prediction of subclinical heart morbidity.

Patients And Methods: Twenty-five patients were enrolled in our study. Read More

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http://dx.doi.org/10.21873/anticanres.14281DOI Listing
May 2020
1.872 Impact Factor

Building a Nomogram for Prediction of Prostate Cancer in Patients With Preoperatively Suspected Prostate Cancer.

Anticancer Res 2020 May;40(5):2995-3002

Department of Anatomical Pathology, Tungs' Taichung Metro Harbor Hospital, Taichung, Taiwan, R.O.C.

Background/aim: Expanded indications for patients with preoperatively suspected prostate cancer (PC) undergoing theranostic robotic-assisted laparoscopic radical prostatectomy (T-RARP) are reported. We aimed to build a nomogram of T-RARP to predict final pathologically proven PC. This study reviewed data of 153 patients that underwent T-RARP for suspected PC performed by the same surgeon. Read More

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http://dx.doi.org/10.21873/anticanres.14280DOI Listing

The Role of Magnetic Resonance Imaging in the Pre-operative Evaluation of Women Diagnosed With Atypical Endometrial Hyperplasia.

Anticancer Res 2020 05;40(5):2989-2993

Department of Obstetrics and Gynaecology, Norfolk and Norwich University Hospital, Norwich, U.K.

Background/aim: To evaluate the role of MRI in patients with atypical endometrial hyperplasia (AEH) and incorporate MRI findings in predictive models estimating the risk of co-existent endometrial cancer (EC).

Patients And Methods: Data from 189 women diagnosed with AEH and had MRI scan prior to operation, over nine years, were retrospectively collected.

Results: Histology showed EC in 51 (27%) cases. Read More

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http://dx.doi.org/10.21873/anticanres.14279DOI Listing
May 2020
1.872 Impact Factor

A Randomized Phase II Study of Maintenance Bevacizumab, Pemetrexed or Bevacizumab Plus Pemetrexed for Advanced Non-squamous Non-small Cell Lung Cancer.

Anticancer Res 2020 May;40(5):2981-2987

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/aim: Continuation maintenance therapy is standard for advanced nonsquamous non-small cell lung cancer; however, the optimal maintenance strategy has yet to be determined.

Patients And Methods: Patients without disease progression after four cycles of carboplatin (CBDCA)+ pemetrexed (PEM)+ bevacizumab (BEV) were randomized to maintenance therapy with BEV, PEM, or BEV+PEM. The primary endpoint was 1-year progression-free survival (PFS) rate. Read More

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http://dx.doi.org/10.21873/anticanres.14278DOI Listing

The Role of Predictive Model Based on Quantitative Basic Magnetic Resonance Imaging in Differentiating Medulloblastoma from Ependymoma.

Anticancer Res 2020 May;40(5):2975-2980

School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background/aim: Even though advanced magnetic resonance imaging (MRI) can effectively differentiate between medulloblastoma and ependymoma, it is not readily available throughout the world. This study aimed to investigate the role of simple quantified basic MRI sequences in the differentiation between medulloblastoma and ependymoma in children.

Patients And Methods: The institutional review board approved this prospective study. Read More

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http://dx.doi.org/10.21873/anticanres.14277DOI Listing

Defecatory Dysfunction After Colon Cancer Resection: The Role of Inferior Mesenteric Artery Tie.

Anticancer Res 2020 May;40(5):2969-2974

Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy.

Background: Although oncological results for resection of colon cancer with inferior mesenteric artery (IMA) ligation at its origin (high tie) or immediately below the left colic artery (low tie) are similar, injury of the superior hypogastric plexus may be caused when the IMA is tied at its origin, thus impairing defecatory functions.

Aim: The importance of IMA tie location on defecatory dysfunction in patients undergoing laparoscopic sigmoidal resection without preoperative radiation therapy was studied.

Patients And Methods: From February 2013 to December 2018, 56 consecutive patients submitted to curative laparoscopic resection for stage II and III, M0, sigmoidal cancer were randomized to a high or low tie of the IMA. Read More

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http://dx.doi.org/10.21873/anticanres.14276DOI Listing
May 2020
1.872 Impact Factor

Clinicopathological Significance of MTUS1 Expression in Patients With Renal Cell Carcinoma.

Anticancer Res 2020 May;40(5):2961-2967

Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

Background/aim: Microtubule-associated tumor suppressor 1 (MTUS1) is a novel tumor suppressor involved in proliferation and migration, and down-regulation of MTUS1 is associated with the poor prognosis of several cancers. We evaluated the clinicopathological significance of MTUS1 expression in renal cell carcinoma (RCC).

Patients And Methods: We assessed MTUS1 expression by immunohistochemical staining of tissue microarrays from 249 cases of RCC. Read More

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http://dx.doi.org/10.21873/anticanres.14275DOI Listing

Efficacy and Safety of Weekly Paclitaxel in Breast Cancer With Symptomatic Bone Marrow Infiltration.

Anticancer Res 2020 May;40(5):2955-2960

Breast Cancer Unit, Centre François Baclesse, Institut Normand du Sein, Caen, France.

Background/aim: Currently, there is no recommendation for the treatment of breast cancer (BC) with bone-marrow cell infiltration (BMI). We evaluated the efficacy and safety of weekly-paclitaxel in this population.

Patients And Methods: This retrospective study included all BC patients with BMI receiving weekly-paclitaxel between January 2014 and May 2018. Read More

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http://dx.doi.org/10.21873/anticanres.14274DOI Listing

Expression of MicroRNA in Locoregional Recurrent Rectal Cancer.

Anticancer Res 2020 May;40(5):2947-2953

University Department for General - and Visceral Surgery, Klinikum Oldenburg AöR, European Medical School (EMS), Oldenburg, Germany

Background/aim: miRNA expression patterns vary within primary rectal cancers and play a pivotal role in carcinogenesis. It is unknown, however, if these regulatory changes also play a role in local recurrent rectal cancers. In this study, the expression of various angiogenetic small non-coding ribonucleic acids, namely miRNA-21, miRNA-215, miRNA-221, and miRNA-222 were analysed in cancerous and healthy rectal tissues. Read More

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http://dx.doi.org/10.21873/anticanres.14273DOI Listing

Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma.

Anticancer Res 2020 May;40(5):2941-2946

Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan

Background/aim: The spliceosome pathway, including Splicing Factor 3b Subunit 4 (SF3B4), plays an important role in carcinogenesis and progression in various cancers; however, the clinical relevance of SF3B4 in esophageal squamous cell carcinoma (ESCC) remains unknown.

Patients And Methods: SF3B4 expression was evaluated by real-time reverse transcription polymerase chain reaction in 80 ESCC patients. In order to explore the mechanism of SF3B4 in ESCC, the mRNA expression and copy number of SF3B4 were obtained from TCGA and we also implemented gene set enrichment analysis (GSEA). Read More

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http://dx.doi.org/10.21873/anticanres.14272DOI Listing

Primary Peritoneal High-grade Serous Carcinoma Misinterpreted as Metastatic Breast Carcinoma: A Rare Encounter in Peritoneal Fluid Cytology.

Anticancer Res 2020 May;40(5):2933-2939

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Background/aim: Peritoneal fluid (PF) cytology is critical for distinguishing high-grade serous carcinoma (HGSC) from metastatic disease in patients with breast carcinoma who present with peritoneal carcinomatosis (PC).

Case Report: A 50-year-old woman underwent surgery and adjuvant therapy for pT1N0 grade 2/2 luminal A breast carcinoma. Sixteen months postoperatively, palliative chemotherapy was administered following a pleural biopsy and diagnosis of metastatic carcinoma. Read More

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http://dx.doi.org/10.21873/anticanres.14271DOI Listing

Quantitative Assessment of Contrast Enhancement on Contrast Enhancement Spectral Mammography (CESM) and Comparison With Qualitative Assessment.

Anticancer Res 2020 May;40(5):2925-2932

University of Rzeszow, Faculty of Medicine, Rzeszow, Poland

Background/aim: Contrast enhanced spectral mammography (CESM) is a novel method of breast cancer diagnosis. Benign lesions are enhanced after contrast injection on both CESM and breast magnetic resonance imaging (MRI). Kinetic curves on breast MRI facilitate differentiation between benign and malignant lesions, while on CESM there is no such possibility and we need to asses lesions based only on their level of enhancement and its patterns. Read More

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http://dx.doi.org/10.21873/anticanres.14270DOI Listing

Characterization and Prognosis of Secondary Acute Myeloid Leukemia in an Asian Population: AML With Antecedent Hematological Disease Confers Worst Outcomes, Irrespective of Cytogenetic Risk.

Anticancer Res 2020 May;40(5):2917-2924

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea

Background/aim: Acute myeloid leukemia (AML) is a biologically heterogeneous disease that can be classified into de novo AML and secondary AML. Secondary AML can be further divided into therapy-related AML (t-AML) or AML evolving from antecedent hematological disorder (AHD-AML). This study evaluated the characteristics and prognosis of secondary AML in a homogeneous East Asian population who are often under-represented. Read More

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http://dx.doi.org/10.21873/anticanres.14269DOI Listing

Targeted Therapy Followed by Cytotoxic Chemotherapy in Preoperative Patients With Locally Advanced Lung Adenocarcinoma.

Anticancer Res 2020 May;40(5):2911-2916

Department of General Thoracic Surgery, Kagoshima University Graduate School of Dental and Medical Sciences, Kagoshima, Japan.

Background: Although oncogene-targeted therapy is a first-line treatment for advanced, unresectable lung adenocarcinoma harboring a target gene mutation, its effect on potentially resectable, locally advanced lung adenocarcinoma remains unclear.

Patients And Methods: Ten patients with clinically diagnosed stage III lung adenocarcinoma harboring a target gene mutation were enrolled in the current feasibility study of targeted therapy followed by cytotoxic chemotherapy (platinum and pemetrexed) before radical surgery.

Results: Complete resection was accomplished in all nine patients who went on to surgery (one patient refused surgery), and all of these patients recovered without major postoperative complications. Read More

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http://dx.doi.org/10.21873/anticanres.14268DOI Listing

Whole-bladder Radiation Therapy for Lymph Node-negative Bladder Cancer With Muscle Invasion in Elderly Patients.

Anticancer Res 2020 May;40(5):2905-2909

Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan.

Background: The Japanese bladder cancer treatment guidelines recommend concurrent chemoradiotherapy, including wide pelvic irradiation. Many elderly patients, however, cannot tolerate standard treatment because of low performance status. Therefore, to reduce complications, elderly patients sometimes receive radiation therapy without elective nodal irradiation or chemotherapy. Read More

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http://dx.doi.org/10.21873/anticanres.14267DOI Listing

Elderly Age Is Associated With More Conservative Treatment of Invasive Melanoma.

Anticancer Res 2020 May;40(5):2895-2903

Division of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, CA, U.S.A.

Background/aim: Competing mortality risks complicate treatment of elderly melanoma patients potentially leading to conservative management, including no sentinel lymph node biopsy. As systemic immunotherapy offers justification for nodal evaluation, we examined treatment trends among elderly melanoma patients.

Patients And Methods: We performed a National Cancer Database analysis of melanoma patients from 2004-2015. Read More

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http://dx.doi.org/10.21873/anticanres.14266DOI Listing

Resection for Internal Jugular Vein Thrombosis and Cervical Lymph Nodes' Involvement from Gastric Cancer.

Anticancer Res 2020 May;40(5):2889-2893

Department of Pathology, University of Rome 'La Sapienza', Rome, Italy.

Background/aim: Thrombosis internal jugular vein (IJV) with cervical adenopathy, as first manifestation of gastric cancer is rare. We aimed to compare resection of the cervical mass followed by gastrectomy with gastrectomy alone.

Patients And Methods: Nine patients presenting thrombosis of the IJV for gastric carcinoma were divided into two groups. Read More

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http://dx.doi.org/10.21873/anticanres.14265DOI Listing

Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8 T Cells in Biliary Tract Cancer.

Anticancer Res 2020 May;40(5):2881-2887

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background/aim: This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8 tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8 TILs in biliary tract cancers (BTCs).

Patients And Methods: A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. Read More

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http://dx.doi.org/10.21873/anticanres.14264DOI Listing
May 2020
1.872 Impact Factor

Prognostic Significance of Neutrophil-to-lymphocyte Ratio in Luminal Breast Cancers With Low Levels of Tumour-infiltrating Lymphocytes.

Anticancer Res 2020 May;40(5):2871-2880

Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine, Nishinomiya, Japan

Background/aim: This study aimed to improve the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and tumour-infiltrating lymphocytes (TILs).

Patients And Methods: In this retrospective study, NLR and TIL data from 677 operated breast cancer patients were analysed. The cut-off value of NLR was set at 2. Read More

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http://dx.doi.org/10.21873/anticanres.14263DOI Listing

Impact of Cytoreductive Surgery and HIPEC on Intraoperative Gastrointestinal Wall Thickness and Patient Outcomes.

Anticancer Res 2020 May;40(5):2865-2869

Department of Surgery, St. George Hospital, Kogarah, NSW, Australia

Background: Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is associated with significant postoperative ileus (POI). This study examined intraoperative gastrointestinal wall thickness (GWT) and its association with patient outcomes.

Patients And Methods: A prospective study of patients undergoing CRS and HIPEC. Read More

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http://dx.doi.org/10.21873/anticanres.14262DOI Listing

Incidental Testicular Pathologies in Patients With Idiopathic Hydrocele Testis: Is Preoperative Scrotal Ultrasound Justified?

Anticancer Res 2020 May;40(5):2861-2864

Department of Urology, Medical University Innsbruck, Innsbruck, Austria

Background/aim: Hydrocele testis is a common disease with a prevalence of 1% in adults. Although it can be diagnosed by physical examination, scrotal ultrasound represents a standard diagnostic tool, to exclude underlying pathologies among them testicular or scrotal malignancies.

Patients And Methods: We conducted a retrospective analysis of 156 patients aged between 20 and 60 years who underwent surgical hydrocelectomy between 2003 and 2018. Read More

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http://dx.doi.org/10.21873/anticanres.14261DOI Listing

Outcome and Toxicity of Carbon Ion Radiotherapy for Axial Bone and Soft Tissue Sarcomas.

Anticancer Res 2020 May;40(5):2853-2859

National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.

Background/aim: Definitive radiotherapy for bone and soft tissues sarcomas benefits patients deemed unfit for surgery; poor outcomes have been reported with conventional photons, while interesting preliminary results have been described with particle in single-Institution experiences. The aim of the study was to retrospectively evaluate preliminary results of carbon ion radiotherapy (CIRT) in patients with axial bone and soft tissue sarcomas (BSTS) treated with curative intent at the National Center for Oncological Hadrontherapy (CNAO).

Patients And Methods: From January 2013 to September 2018, 54 patients with axial BSTS were treated with CIRT at CNAO. Read More

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http://dx.doi.org/10.21873/anticanres.14260DOI Listing

Evaluation of Five Survival Scores in a Cohort of Elderly Patients With Cerebral Metastasis from Non-small Cell Lung Cancer.

Anticancer Res 2020 May;40(5):2847-2851

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Survival scores are important for treatment personalisation. A score for older patients with cerebral metastasis from non-small cell lung cancer (NSCLC) was generated.

Patients And Methods: Dose-fractionation of whole-brain irradiation, age, gender, general condition, histology, count of cerebral lesions, extra-cerebral metastatic spread and time between NSCLC-diagnosis and whole-brain irradiation were analysed for survival in 285 patients. Read More

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http://dx.doi.org/10.21873/anticanres.14259DOI Listing

Extra-cerebral Metastasis - An Independent Predictor of Survival in Older Patients With Brain Metastases Receiving a Local Therapy Plus Whole-Brain Radiotherapy (WBRT).

Anticancer Res 2020 May;40(5):2841-2845

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Although omitting whole-brain radiotherapy (WBRT) during the treatment of few brain metastases more popular, many patients receive local therapies plus WBRT. WBRT may be less reasonable for patients with poor overall survival (OS), particularly if they are older. This study aimed to identify predictors of OS in these patients. Read More

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http://dx.doi.org/10.21873/anticanres.14258DOI Listing

The Prognostic Value of the Number of Harvested Negative Lymph Nodes in Patients Treated by Esophagectomy With or Without Neoadjuvant Chemoradiation.

Anticancer Res 2020 May;40(5):2833-2840

Department of General and Visceral Surgery, Friedrich Alexander University, Erlangen, Germany.

Background/aim: The prognostic value of the number of harvested negative lymph nodes (NLNs) in patients with node-negative esophageal carcinoma treated by esophagectomy with or without neoadjuvant chemoradiation is unclear.

Patients And Methods: A total of 136 patients who underwent oncological esophagectomy with two-field lymphadenectomy from 1995 to 2014 were analyzed regarding the prognostic impact of NLNs. 86 patients received primary surgery (group 1) and 50 patients had preoperative chemoradiation followed by surgery (group 2). Read More

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http://dx.doi.org/10.21873/anticanres.14257DOI Listing

Phase II Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Unresectable Esophageal Cancer.

Anticancer Res 2020 May;40(5):2827-2832

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.

Background/aim: We performed a phase II study of triple-drug combination chemoradiotherapy (DCF-R therapy), in which docetaxel was added to the standard chemoradiotherapy (cisplatin [CDDP]/5-fluorouracil [5-FU]) for unresectable advanced esophageal cancer.

Patients And Methods: Sixty-one patients with unresectable advanced esophageal cancer underwent the following DCF-R therapy: intravenous infusion of l60 mg/m docetaxel and 60 mg/m of CDDP (day 1), and 600 mg/m of 5-FU (days 1-5); 2 courses administered within a 4-week interval. Radiotherapy comprised 60 Gy in total. Read More

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http://dx.doi.org/10.21873/anticanres.14256DOI Listing

Two Malignancies With Differential Responses to Immune Checkpoint Inhibitors: A Case Report.

Anticancer Res 2020 May;40(5):2821-2826

University of Minnesota, Department of Medicine, Division of Hematology, Oncology, and Transplantation, Minneapolis, MN, U.S.A.

Background: Immune checkpoint inhibitors (ICI) have changed the management of cancer dramatically. However, not all patients respond to ICI and their use places patients at a significant risk of immune-related adverse reactions. A few biomarkers including programmed death-1 receptor/programmed death-ligand 1 (PD-1/PD-L1), micro-satellite instability (MSI) status, and tumor mutational burden (TMB) have gained popularity as surrogates to predict responsiveness to ICI. Read More

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http://dx.doi.org/10.21873/anticanres.14255DOI Listing

Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient.

Anticancer Res 2020 May;40(5):2813-2819

AntiCancer, Inc., San Diego, CA, U.S.A.

Background/aim: Methionine addiction is a general and fundamental hallmark of cancer. Methionine addiction can be targeted by methionine restriction (MR). Our laboratory has studied methionine addiction in cancer and MR for almost 50 years. Read More

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http://dx.doi.org/10.21873/anticanres.14254DOI Listing

Impact of the Lysine-urethane Adhesive TissuGlu® on Postoperative Complications and Interventions After Drain-free Mastectomy.

Anticancer Res 2020 May;40(5):2801-2812

Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany

Background/aim: The influence of a polyurethane-based tissue adhesive (TissuGlu®) on common complications following breast surgery was investigated.

Patients And Methods: Within a Randomized-Controlled-Trial 70 women (n=35 TissuGlu®, n=35 drain) underwent a mastectomy with or without sentinel lymph node excision (SLNE), followed by a 90-day postoperative follow-up.

Results: Postoperative interventions: Non-inferiority of the application of TissuGlu® was seen. Read More

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http://dx.doi.org/10.21873/anticanres.14253DOI Listing

Inflammatory Liver Tumor Caused by Mimicking Intrahepatic Cholangiocarcinoma.

Anticancer Res 2020 May;40(5):2795-2800

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

Human fascioliasis is a rare parasitic disease outside of countries in which it is endemic. The diagnosis of hepatic-phase fascioliasis by diagnostic imaging alone is challenging. A 69-year-old female was referred to our hospital for the treatment of a solitary solid cystic mass lesion, 6 cm in diameter, accompanied with mild symptoms and minimal changes in laboratory parameters. Read More

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http://dx.doi.org/10.21873/anticanres.14252DOI Listing

Significance of Quantitative Interferon-gamma Levels in Non-small-cell Lung Cancer Patients' Response to Immune Checkpoint Inhibitors.

Anticancer Res 2020 May;40(5):2787-2793

Department of Thoracic Oncology, Osaka Habikino Medical Center, Osaka, Japan.

Background/aim: We aimed to study the association between the quantitative interferon-gamma (IFN-γ) levels and clinical outcomes in non-small-cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs).

Patients And Methods: Sample collection for IFN-γ release assay (IGRA) was performed within 14 days before treatment (T1), on day 22±7 (T3), and on day 43±7 (T4). The stored specimens over 10 IU/ml in IGRA were re-examined using the dilution method (with saline as the dilution medium). Read More

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http://dx.doi.org/10.21873/anticanres.14251DOI Listing

Five Genes Associated With Survival in Patients With Lower-grade Gliomas Were Identified by Information-theoretical Analysis.

Anticancer Res 2020 May;40(5):2777-2785

Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.

Background/aim: Understanding of the molecular events associated with progression and survival differences in patients with lower-grade gliomas (LGGs) is still unclear. The comparison of findings across studies using different datasets and methods is essential for a new molecular-based classification system. The aim of the study was to identify biomarkers for prognostic classification of patients with LGGs, and furthermore to lay a foundation for future development of targeted therapies for LGGs. Read More

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http://dx.doi.org/10.21873/anticanres.14250DOI Listing

Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Locally Recurrent Pancreatic Cancer After Surgical Resection.

Anticancer Res 2020 May;40(5):2771-2775

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background/aim: Irreversible electroporation (IRE) has recently been used as an experimental treatment for cancers including locally advanced pancreatic cancer. There is very limited data on IRE in pancreatic cancer that is locally recurrent after surgical resection. The aim of this study was to evaluate the safety and efficacy of IRE in this setting. Read More

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http://dx.doi.org/10.21873/anticanres.14249DOI Listing

Neoadjuvant Chemotherapy Reduces the Treatment-free Interval After First-line Treatment in Patients With Advanced Ovarian Cancer.

Anticancer Res 2020 May;40(5):2765-2770

Department of Gynecology, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background/aim: The aim of the study was to compare platinum resistance and treatment-free interval (TFI) following treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) or primary debulking surgery (PDS) in women with advanced epithelial ovarian cancer (EOC).

Patients And Methods: The study included patients diagnosed with primary EOC, stage IIIC or IV, between 2005 and 2013. Patients were grouped according to first-line treatment (PDS vs. Read More

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http://dx.doi.org/10.21873/anticanres.14248DOI Listing

MRI Lymph Node Evaluation for Prediction of Metastases in Rectal Cancer.

Anticancer Res 2020 May;40(5):2757-2763

Department of Biomedical and Clinical Sciences, Division of Surgery, Linköping University, Linköping, Sweden.

Aim: To explore whether the size and characteristics of the largest regional lymph node in patients with rectal cancer, based on magnetic resonance imaging (MRI), following neoadjuvant therapy and before surgery, is able to identify patients at high risk of developing metachronous metastases.

Patients And Methods: A retrospective case-control study with data from the Swedish Colo-Rectal Cancer Registry. Forty patients were identified with metachronous metastases (M+), and 40 patients without metastases (M0) were matched as controls. Read More

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http://dx.doi.org/10.21873/anticanres.14247DOI Listing

Utility of the Free Vascularized Fibula Flap to Reconstruct Oncologic Defects in the Upper Extremity.

Anticancer Res 2020 May;40(5):2751-2755

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, U.S.A.

Background/aim: Non-vascularized methods to reconstruct bone defects following tumor resection are associated with complications. As a result, the free vascularized fibular flap (FVF) has become a mainstay for reconstruction. The purpose of this study was to analyze FVF reconstruction in the upper extremity. Read More

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http://dx.doi.org/10.21873/anticanres.14246DOI Listing

Cell Cycle Arrest and Apoptotic Effect of 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) Ciprofloxacin-derivative on HCT 116 and A549 Cancer Cells.

Anticancer Res 2020 May;40(5):2739-2749

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

Background/aim: Ciprofloxacin has been used as an antibiotic in the clinic for decades. Recently, ciprofloxacin and its derivatives have shown promising anti-proliferative and cytotoxic activities against several malignant cells. The aim of this study was to investigate the effect of a new derivative of ciprofloxacin on colorectal cancer (HCT116) and non-small lung carcinoma (A549) cells. Read More

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http://dx.doi.org/10.21873/anticanres.14245DOI Listing

Glioblastoma Factors Increase the Migration of Human Brain Endothelial Cells by Increasing MMP-9/CXCR4 Levels.

Anticancer Res 2020 May;40(5):2725-2737

Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, Brazil

Background/aim: Glioblastoma (GB) is the most aggressive type of tumor in the central nervous system and is characterized by resistance to therapy and abundant vasculature. Tumor vessels contribute to the growth of GB, and the tumor microenvironment is thought to influence tumor vessels. We evaluated the molecular communication between human GB cells and human brain microvascular endothelial cells (HBMEC) in vitro. Read More

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http://dx.doi.org/10.21873/anticanres.14244DOI Listing

Tumor-associated Macrophages Facilitate Bladder Cancer Progression by Increasing Cell Growth, Migration, Invasion and Cytokine Expression.

Anticancer Res 2020 May;40(5):2715-2724

Sex Hormone Research Center and Department of Laboratory Medicine and Biotechnology, China Medical University and Hospital, Taichung, Taiwan, R.O.C.

Background/aim: Interactions between stromal and tumor cells in tumor microenvironment contribute to tumor progression. In bladder cancer (BCa), infiltration of macrophages in tumors correlates with cancer progression. Herein, the aim was to study the paracrine effects of tumor-associated macrophages (TAM) on BCa cells. Read More

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http://dx.doi.org/10.21873/anticanres.14243DOI Listing

Adjuvant Postoperative CD40 Agonist and PD-1 Antagonist Combination Therapy in Syngeneic Tongue Cancer Mouse Model.

Anticancer Res 2020 May;40(5):2707-2713

Department of Otorhinolaryngology Head & Neck Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background/aim: Using a syngeneic tongue cancer mouse model, the effect of CD40 agonist and PD-1 antagonist combination therapy for local recurrence after surgery was evaluated in a partially depleted CD4 model.

Materials And Methods: C3H/HeN mice were injected with 0.05 mg of the anti-mouse CD4 clone GK1. Read More

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http://dx.doi.org/10.21873/anticanres.14242DOI Listing

A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments.

Anticancer Res 2020 May;40(5):2701-2706

Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan

Background/aim: Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement.

Materials And Methods: A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. Read More

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http://dx.doi.org/10.21873/anticanres.14241DOI Listing

Tumour Budding Is an Independent Predictive Factor of Cutaneous Squamous-cell Carcinoma Aggressiveness.

Anticancer Res 2020 May;40(5):2695-2699

Department of Dermatology, Ed. Herriot Hospital Group, Lyon, France

Background/aim: Tumour budding (TB), i.e. the presence of groups of ≤5 tumour cells ahead of the invasive tumour front, is a pathological feature associated with an aggressive outcome in several cancer types. Read More

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http://dx.doi.org/10.21873/anticanres.14240DOI Listing

Urethane-induced Mammary Carcinogenesis Susceptibility in Transgenic Mice Expressing a Dominant-negative TGF-β Type II Receptor.

Anticancer Res 2020 May;40(5):2687-2694

Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, Takatsuki, Japan.

Background/aim: Transforming growth factor-β (TGF-β) plays dual suppressive and oncogenic roles in mammary carcinogenesis.

Materials And Methods: To analyze whether TGF-β exerts suppressive or oncogenic actions on mammary carcinogenesis, transgenic mice overexpressing a dominant-negative mutant type II TGF-β receptor (TβRII-DNR) driven by the mouse mammary tumor virus (MMTV) promoter were treated with a low dose of urethane, a carcinogen present in fermented food products and alcoholic beverages.

Results: Lobular proliferative lesions, showing high β-casein expression, developed in the mammary glands of TβRII-DNR mice aged >61 weeks. Read More

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http://dx.doi.org/10.21873/anticanres.14239DOI Listing

Inhibition of Jurkat T Cell Growth by -farnesyl-norcantharimide Through Up-regulation of Tumor Suppressor Genes and Down-regulation of Genes for Steroid Biosynthesis, Metabolic Pathways and Fatty Acid Metabolism.

Anticancer Res 2020 May;40(5):2675-2685

Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.

Background/aim: To evaluate the anti-cancer mechanism of N-Farnesyl-norcantharimide (NC15).

Materials And Methods: The viability of NC15-treated human leukemic Jurkat T (JKT) cells was assessed using the Kit-8 cell counting method. Flow cytometry analysis, human apoptosis antibody array assay, and whole genome sequencing were adopted to investigate the mechanism underlying the anti-cancer activity of NC15 in JKT cells. Read More

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http://dx.doi.org/10.21873/anticanres.14238DOI Listing

Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic Mutation.

Anticancer Res 2020 May;40(5):2667-2673

Department of General Thoracic, Breast, and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Background/aim: The therapeutic strategy for patients with non-small-cell lung cancer (NSCLC) harboring the BRAF non-V600E mutation has not been established. LY3009120, a newly discovered pan-RAF inhibitor, has shown strong antitumor effects in cancers with various BRAF genotypes. This study investigated the antitumor effects of LY3009120 in NSCLC cells harboring the BRAF non-V600E mutation. Read More

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http://dx.doi.org/10.21873/anticanres.14237DOI Listing

High Nitric Oxide Adaptation in Isogenic Primary and Metastatic Head and Neck Cancer Cells.

Anticancer Res 2020 May;40(5):2657-2665

Oral Biology Research Unit, Faculty of Dentistry, Thammasat University (Rangsit Campus), Pathum Thani, Thailand.

Background/aim: Nitric oxide (NO) functions have been studied in many cancer types, but rarely in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the behavior of HNSCC cells following exposure to high NO (HNO).

Materials And Methods: Two pairs of isogenic HNSCC cell lines (HN18/HN17, HN30/HN31) were used, and were treated with a NO donor for 72 h. Read More

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http://dx.doi.org/10.21873/anticanres.14236DOI Listing

Decreases the Sensitivity of Head and Neck Squamous Cell Carcinoma Cells to Radiation and Cisplatin.

Anticancer Res 2020 May;40(5):2645-2655

Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand

Background/aim: Two-thirds of head and neck squamous cell carcinoma (HNSCC) patients present with locally advanced (LA) stages and have a poor survival rate. The aim of this study was to investigate the roles of the long non-coding RNAs MALAT1 on radiation and cisplatin sensitivity of HNSCC cells.

Materials And Methods: Clonogenic, cell viability, and apoptosis assays were performed in cells following MALAT1 knockdown using CRISPR/Cas9 system. Read More

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http://dx.doi.org/10.21873/anticanres.14235DOI Listing

Establishment of a Liver Transplant Patient-derived Tumor Xenograft (PDX) Model Using Cryopreserved Pancreatic Ductal Adenocarcinoma.

Anticancer Res 2020 May;40(5):2637-2644

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background/aim: There is rapid progression and widespread use of patient-derived tumor xenografts (PDX) in translational pancreatic cancer research. This study aimed to establish a liver transplant PDX model using cryopreserved primary pancreatic ductal adenocarcinoma (PDAC).

Patients And Methods: Primary PDAC from 10 patients were cryopreserved and transplanted into immunodeficient mice using the liver pocket method. Read More

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http://dx.doi.org/10.21873/anticanres.14234DOI Listing
May 2020
1.872 Impact Factor

Periostin Plays a Key Role in Radioresistance of Head and Neck Cancer Cells Epithelial-to-Mesenchymal Transition.

Anticancer Res 2020 May;40(5):2627-2635

Department of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea

Background/aim: Head and neck squamous cell carcinoma (HNSCC) is an aggressive head and neck malignancy. The aim of this study was to elucidate the role of periostin (POSTN) in the epithelial-to-mesenchymal transition (EMT) process mediating the acquisition of radioresistance in HNSCC.

Materials And Methods: The expression levels of EMT hallmark genes including POSTN and Erk/Akt signaling pathways were compared between radiosensitive and radioresistant HNSCC cells. Read More

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http://dx.doi.org/10.21873/anticanres.14233DOI Listing